MYEOV Gene
protein-coding GIFtS: 43
GCID: GC11P069061
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|
myeloma overexpressed (in a subset of t(11;14) positive...
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Aliases
for MYEOV gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myeloma Overexpressed (In A Subset Of T(11;14) Positive MultipleMyelomas)1 2 | | OCIM1 2 3 | | Oncogene In Multiple Myeloma2 3 | | Myeloma Overexpressed Gene (In A Subset Of T(11;14) Positive Multiple Myelomas)2 | | Myeloma-Overexpressed Gene Protein2 |
Export aliases for MYEOV gene to outside databasesPrevious GC identifers: GC11P071586 GC11P070758 GC11P069311 GC11P068836 GC11P068818 GC11P065407 |
Summaries
for MYEOV gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MYEOV gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYEOV gene promoter:
AhR RFX1 AML1a Pax-5 Arnt PPAR-gamma1 SRY FAC1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYEOV
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYEOV |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13.2MYEOV Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P069061: view genomic region
(about GC identifiers)
Start:
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69,061,605 bp from pter |
End:
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69,182,494 bp from pter |
Size:
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120,890 bases |
Orientation:
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plus strand |
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Proteins
for MYEOV gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYEOV_HUMAN, Q96EZ4 (See
protein sequence)Recommended Name: Myeloma-overexpressed gene protein Size: 313 amino acids; 33556 Da
Developmental stage: Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation
Sequence caution: Sequence=CAB65726.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9UGN6 Q9UGN7Explore the universe of human proteins at neXtProt for MYEOV: NX_Q96EZ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EZ4
MYEOV Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620123.2
ENSEMBL proteins: ENSP00000412482 ENSP00000308330 ENSP00000438100
Human Recombinant Protein Products:
MYEOV Antibody Products:
Assay Products for MYEOV: |
Protein
Domains /
Families
for MYEOV gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96EZ4 |
Function
for MYEOV gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MYEOV (NM_138768) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYEOV | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYEOV |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEOV |
|
Pathways & Interactions
for MYEOV gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYEOV
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for MYEOV (Q96EZ43 ENSP000003083304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MYEOV gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MYEOV
Search CenterWatch for drugs/clinical trials and news about MYEOV
|
Transcripts
for MYEOV gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYEOV gene: NM_138768.2 Unigene Cluster for MYEOV: Myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) Hs.523848 [show with all ESTs]Unigene Representative Sequence: AJ22336612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441339 ENST00000544008(uc001oox.3) ENST00000539691 ENST00000308946(uc001oov.3)
ENST00000535407(uc001oow.3) ENST00000535653(uc009ysl.3) ENST00000540760
ENST00000535597 ENST00000544781 ENST00000535660 ENST00000541137 ENST00000540356
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYEOV (NM_138768) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYEOV | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYEOV |
Additional cDNA sequence: AJ223366.1 AK000473.1 AK026148.1 AK290121.1 BC011815.2 10 DOTS entries: DT.99960550 DT.100785850 DT.92418787 DT.100785856 DT.97846668 DT.95370592 DT.97846667 DT.97787295 DT.120714841 DT.92043488 24/115 AceView cDNA sequences (see all 115): AI692234 BM834134 BF002284 BF195098 BG035449 BM018182 BF063686 BM549823 BM818098 AA621983 AK026148 BM908504 BM837305 AW204003 BM549473 BM817678 BM833038 BM757326 BM809741 AA621975 AW732776 BQ690958 AA622706 BM837864
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MYEOV
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Expression
for MYEOV gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYEOV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAGGACC
About this image
See MYEOV Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYEOV
SOURCE GeneReport for Unigene cluster: Hs.523848
SABiosciences Custom PCR Arrays for MYEOV
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYEOV
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MYEOV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYEOV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYEOV | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEOV |
Orthologs
for MYEOV gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MYEOV (if available)
TreeFam Gene Tree for MYEOV (if available) |
Paralogs
for MYEOV gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MYEOV gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYEOV (69061605 - 69182494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYEOV: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYEOV |
|
Disorders
/ Diseases
for MYEOV gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYEOV for disorders About GeneDecksing
OMIM gene information: 605625
OMIM disorders: --
9  diseases for MYEOV: About MalaCardsmultiple myeloma myeloma esophageal squamous cell carcinoma squamous cell carcinoma
peripheral t-cell lymphoma esophagitis colon cancer gastric cancer
carcinoma
1 Novoseek disease relationship for MYEOV gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| myeloma |
72.7 |
2 |
10753852 (1), 15090460 (1) |
Human Genome Epidemiology (HuGE) Navigator: MYEOV (2 documents)
Export disorders for MYEOV gene to outside databases
|
Publications
for MYEOV gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYEOV gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MYEOV) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). (PubMed id 10753852)1, 2, 3, 9 Janssen J.W.G.... Schuuring E. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. (PubMed id 12202983)1, 9 Janssen J.W....Inazawa J. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in ne uroblastoma. (PubMed id 21624008)1 Takita J....Ogawa S. (2011)
- MYEOV (myeloma overexpressed gene) drives colon cance r cell migration and is regulated by PGE2. (PubMed id 20569498)1 Lawlor G....Murray D.W. (2010)
- MYEOV is a prognostic factor in multiple myeloma. (PubMed id 20854874)1 Moreaux J....Klein B. (2010)
- Genome-wide association study identifies five new bre ast cancer susceptibility loci. (PubMed id 20453838)1 Turnbull C....Easton D.F. (2010)
- Rearrangement and expression of myeov and hst in NIH/3T3 transfectants: a caveat for the interpretation of DNA transfection analyses. (PubMed id 17390055)1 Brecht M....Janssen J.W. (2007)
- ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion. (PubMed id 16678123)1 Moss A.C....MacMathuna P. (2006)
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External Searches for MYEOV gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MYEOV gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYEOV gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYEOV gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MYEOV gene:
Search GeneIP for patents involving MYEOV
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYEOV gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYEOV | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYEOV | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYEOV | | | OriGene Protein Over-expression Lysate for MYEOV | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYEOV | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYEOV | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MYEOV | | OriGene Custom Protein Services for MYEOV | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYEOV | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYEOV | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYEOV | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYEOV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYEOV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYEOV |
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| | | | Search Tocris compounds for MYEOV |
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 | | | MYEOV Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEOV |
|  |  |  | | | | Search ThermoFisher Antibodies for MYEOV |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYEOV |
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