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Aliases for MYEOV Gene

Aliases for MYEOV Gene

  • Myeloma Overexpressed 2 3
  • Myeloma Overexpressed (In A Subset Of T(11;14) Positive Multiple Myelomas) 2 3
  • Oncogene In Multiple Myeloma 3 4
  • OCIM 3 4
  • Myeloma Overexpressed Gene (In A Subset Of T(11;14) Positive Multiple Myelomas) 3
  • Myeloma-Overexpressed Gene Protein 3

External Ids for MYEOV Gene

Previous GeneCards Identifiers for MYEOV Gene

  • GC11P071586
  • GC11P070758
  • GC11P068836
  • GC11P068818
  • GC11P069061
  • GC11P065407

Summaries for MYEOV Gene

GeneCards Summary for MYEOV Gene

MYEOV (Myeloma Overexpressed) is a Protein Coding gene. Diseases associated with MYEOV include myeloma and multiple myeloma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYEOV Gene

Genomics for MYEOV Gene

Regulatory Elements for MYEOV Gene

Genomic Location for MYEOV Gene

Start:
69,294,138 bp from pter
End:
69,367,726 bp from pter
Size:
73,589 bases
Orientation:
Plus strand

Genomic View for MYEOV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYEOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYEOV Gene

Proteins for MYEOV Gene

  • Protein details for MYEOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ4-MYEOV_HUMAN
    Recommended name:
    Myeloma-overexpressed gene protein
    Protein Accession:
    Q96EZ4
    Secondary Accessions:
    • Q9UGN6
    • Q9UGN7

    Protein attributes for MYEOV Gene

    Size:
    313 amino acids
    Molecular mass:
    33556 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB65726.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MYEOV Gene

Proteomics data for MYEOV Gene at MOPED

Post-translational modifications for MYEOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYEOV Gene

No data available for DME Specific Peptides for MYEOV Gene

Domains for MYEOV Gene

Protein Domains for MYEOV Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MYEOV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYEOV: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYEOV Gene

Function for MYEOV Gene

miRNA for MYEOV Gene

miRTarBase miRNAs that target MYEOV

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYEOV Gene

Localization for MYEOV Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYEOV Gene COMPARTMENTS Subcellular localization image for MYEOV gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYEOV Gene

Pathways for MYEOV Gene

SuperPathways for MYEOV Gene

No Data Available

Interacting Proteins for MYEOV Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308330%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000308330 Q96EZ4-MYEOV_HUMAN for MYEOV Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MYEOV Gene

None

No data available for Pathways by source for MYEOV Gene

Transcripts for MYEOV Gene

Unigene Clusters for MYEOV Gene

Myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8:
SP9: - - -

Relevant External Links for MYEOV Gene

GeneLoc Exon Structure for
MYEOV
ECgene alternative splicing isoforms for
MYEOV

Expression for MYEOV Gene

mRNA expression in normal human tissues for MYEOV Gene

mRNA differential expression in normal tissues according to GTEx for MYEOV Gene

This gene is overexpressed in Esophagus - Mucosa (11.8), Adipose - Subcutaneous (7.0), Skin - Sun Exposed (Lower leg) (5.5), Vagina (4.5), Breast - Mammary Tissue (4.2), and Skin - Not Sun Exposed (Suprapubic) (4.0).

SOURCE GeneReport for Unigene cluster for MYEOV Gene Hs.523848

genes like me logo Genes that share expressions with MYEOV: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MYEOV Gene

Orthologs for MYEOV Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MYEOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYEOV 35
  • 98.32 (n)
  • 95.8 (a)
MYEOV 36
  • 96 (a)
OneToOne
Species with no ortholog for MYEOV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYEOV Gene

ENSEMBL:
Gene Tree for MYEOV (if available)
TreeFam:
Gene Tree for MYEOV (if available)

Paralogs for MYEOV Gene

No data available for Paralogs for MYEOV Gene

Variants for MYEOV Gene

Sequence variations from dbSNP and Humsavar for MYEOV Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4396297 -- 69,293,843(+) TGTCT(C/T)CTGGG upstream-variant-2KB
rs7103126 - 69,295,926(+) AAGGG(C/T)GGTGG missense, reference
rs7112680 -- 69,294,610(+) aagga(A/G)agccc intron-variant, upstream-variant-2KB
rs7117236 -- 69,295,669(+) AAAGC(C/T)GGCAG reference, synonymous-codon
rs7124369 -- 69,293,347(+) TGTGC(C/T)CCACC upstream-variant-2KB

Relevant External Links for MYEOV Gene

HapMap Linkage Disequilibrium report
MYEOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYEOV Gene

Disorders for MYEOV Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MYEOV Gene including...

Search for MYEOV Gene in MalaCards »

(1) Novoseek inferred disease relationships for MYEOV Gene

Disease -log(P) Hits PubMed IDs
myeloma 72.7 2

Relevant External Links for MYEOV

Genetic Association Database (GAD)
MYEOV
Human Genome Epidemiology (HuGE) Navigator
MYEOV
genes like me logo Genes that share disorders with MYEOV: view

No data available for UniProtKB/Swiss-Prot for MYEOV Gene

Publications for MYEOV Gene

  1. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). (PMID: 10753852) Janssen J.W.G. … Schuuring E. (Blood 2000) 2 3 4 23
  2. MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. (PMID: 12202983) Janssen J.W. … Inazawa J. (J. Hum. Genet. 2002) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Control of MYEOV protein synthesis by upstream open reading frames. (PMID: 16275643) de Almeida R.A. … Janssen J.W. (J. Biol. Chem. 2006) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for MYEOV Gene

Sources for MYEOV Gene

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