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Aliases for MYEOV Gene

Aliases for MYEOV Gene

  • Myeloma Overexpressed 2 3 5
  • Myeloma Overexpressed (In A Subset Of T(11;14) Positive Multiple Myelomas) 2 3
  • Oncogene In Multiple Myeloma 3 4
  • OCIM 3 4
  • Myeloma Overexpressed Gene (In A Subset Of T(11;14) Positive Multiple Myelomas) 3
  • Myeloma-Overexpressed Gene Protein 3

External Ids for MYEOV Gene

Previous GeneCards Identifiers for MYEOV Gene

  • GC11P071586
  • GC11P070758
  • GC11P068836
  • GC11P068818
  • GC11P069061
  • GC11P065407

Summaries for MYEOV Gene

GeneCards Summary for MYEOV Gene

MYEOV (Myeloma Overexpressed) is a Protein Coding gene. Diseases associated with MYEOV include Multiple Myeloma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYEOV Gene

Genomics for MYEOV Gene

Regulatory Elements for MYEOV Gene

Enhancers for MYEOV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F069318 1.2 FANTOM5 Ensembl ENCODE 39.8 +26.7 26736 3.9 HDGF CTCF JUN ZIC2 RAD21 FOXK2 POLR2A SCRT2 ZNF143 SMC3 MYEOV MRGPRD IFITM9P GC11P069370
GH11F069336 1 Ensembl ENCODE 26.6 +43.3 43263 1.6 TBL1XR1 TEAD3 RELA CBX5 ETV6 FOS CREM TEAD1 MTA2 BHLHE40 MYEOV IFITM9P GC11P069370
GH11F069316 1.1 Ensembl ENCODE 21.7 +23.7 23693 2.1 CTCF JUN REST JUND POLR2A SMARCA4 SCRT2 FOS ZBTB33 MYEOV IFITM9P GC11P069370
GH11F069335 0.2 Ensembl 20.4 +42.0 41963 0.6 ZNF316 MAFG BACH1 NFE2 EMSY MAFK NFE2L2 MYEOV IFITM9P GC11P069370
GH11F069359 0.5 Ensembl ENCODE 18 +66.3 66279 1.2 BCOR CBX3 ZMYM3 RAD21 YY1 ADNP TRIM24 SMARCA5 ZNF280D HCFC1 MYEOV GC11P069370 IFITM9P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYEOV on UCSC Golden Path with GeneCards custom track

Genomic Location for MYEOV Gene

Chromosome:
11
Start:
69,294,138 bp from pter
End:
69,367,726 bp from pter
Size:
73,589 bases
Orientation:
Plus strand

Genomic View for MYEOV Gene

Genes around MYEOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYEOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYEOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYEOV Gene

Proteins for MYEOV Gene

  • Protein details for MYEOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ4-MYEOV_HUMAN
    Recommended name:
    Myeloma-overexpressed gene protein
    Protein Accession:
    Q96EZ4
    Secondary Accessions:
    • Q9UGN6
    • Q9UGN7

    Protein attributes for MYEOV Gene

    Size:
    313 amino acids
    Molecular mass:
    33556 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB65726.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MYEOV Gene

Post-translational modifications for MYEOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYEOV Gene

No data available for DME Specific Peptides for MYEOV Gene

Domains & Families for MYEOV Gene

Protein Domains for MYEOV Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MYEOV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYEOV: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYEOV Gene

Function for MYEOV Gene

Phenotypes for MYEOV Gene

genes like me logo Genes that share phenotypes with MYEOV: view

Animal Model Products

miRNA for MYEOV Gene

miRTarBase miRNAs that target MYEOV

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYEOV Gene

Localization for MYEOV Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYEOV Gene COMPARTMENTS Subcellular localization image for MYEOV gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYEOV Gene

Pathways & Interactions for MYEOV Gene

SuperPathways for MYEOV Gene

No Data Available

Interacting Proteins for MYEOV Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308330%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q96EZ4-MYEOV_HUMAN ENSP00000308330 for MYEOV Gene via IID STRING

Gene Ontology (GO) - Biological Process for MYEOV Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYEOV Gene

Transcripts for MYEOV Gene

Unigene Clusters for MYEOV Gene

Myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8:
SP9: - - -

Relevant External Links for MYEOV Gene

GeneLoc Exon Structure for
MYEOV
ECgene alternative splicing isoforms for
MYEOV

Expression for MYEOV Gene

mRNA expression in normal human tissues for MYEOV Gene

mRNA differential expression in normal tissues according to GTEx for MYEOV Gene

This gene is overexpressed in Esophagus - Mucosa (x11.8), Adipose - Subcutaneous (x7.0), Skin - Sun Exposed (Lower leg) (x5.5), Vagina (x4.5), Breast - Mammary Tissue (x4.2), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MYEOV Gene:

MYEOV

SOURCE GeneReport for Unigene cluster for MYEOV Gene:

Hs.523848
genes like me logo Genes that share expression patterns with MYEOV: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYEOV Gene

Orthologs for MYEOV Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MYEOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYEOV 34 35
  • 98.32 (n)
Species where no ortholog for MYEOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MYEOV Gene

ENSEMBL:
Gene Tree for MYEOV (if available)
TreeFam:
Gene Tree for MYEOV (if available)

Paralogs for MYEOV Gene

No data available for Paralogs for MYEOV Gene

Variants for MYEOV Gene

Sequence variations from dbSNP and Humsavar for MYEOV Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111392283 -- 69,294,299(+) GGGCG(A/G)GAGAT utr-variant-5-prime
rs11228608 -- 69,294,492(-) AGAAG(C/T)GTCCA utr-variant-5-prime
rs11228610 -- 69,296,261(+) TGGGG(C/G)GGTGG reference, missense
rs11228611 -- 69,297,555(+) CTCCC(A/G)CCGCA downstream-variant-500B
rs113095994 -- 69,292,943(+) CCACC(A/G)CCATC upstream-variant-2KB

Variation tolerance for MYEOV Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYEOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYEOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYEOV Gene

Disorders for MYEOV Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYEOV Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
- elite association - COSMIC cancer census association via MalaCards
Search MYEOV in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYEOV

Genetic Association Database (GAD)
MYEOV
Human Genome Epidemiology (HuGE) Navigator
MYEOV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYEOV
genes like me logo Genes that share disorders with MYEOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYEOV Gene

Publications for MYEOV Gene

  1. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). (PMID: 10753852) Janssen J.W.G. … Schuuring E. (Blood 2000) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. (PMID: 12202983) Janssen J.W. … Inazawa J. (J. Hum. Genet. 2002) 3 22 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-wide association scan for variants associated with early-onset prostate cancer. (PMID: 24740154) Lange E.M. … Cooney K.A. (PLoS ONE 2014) 3 64

Products for MYEOV Gene

Sources for MYEOV Gene

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