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Aliases for MYEF2 Gene

Aliases for MYEF2 Gene

  • Myelin Expression Factor 2 2 3
  • MyEF-2 3 4
  • MST156 3 4
  • MEF-2 3 4
  • Myelin Gene Expression Factor 2 3
  • HsT18564 3
  • KIAA1341 4
  • MSTP156 3

External Ids for MYEF2 Gene

Summaries for MYEF2 Gene

GeneCards Summary for MYEF2 Gene

MYEF2 (Myelin Expression Factor 2) is a Protein Coding gene. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Physiological and Pathological Hypertrophy of the Heart. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is HNRNPM.

UniProtKB/Swiss-Prot for MYEF2 Gene

  • Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5-TTGTCC-3 of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYEF2 Gene

Genomics for MYEF2 Gene

Genomic Location for MYEF2 Gene

Start:
48,134,631 bp from pter
End:
48,178,517 bp from pter
Size:
43,887 bases
Orientation:
Minus strand

Genomic View for MYEF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYEF2 Gene

Regulatory Elements for MYEF2 Gene

Proteins for MYEF2 Gene

  • Protein details for MYEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K5-MYEF2_HUMAN
    Recommended name:
    Myelin expression factor 2
    Protein Accession:
    Q9P2K5
    Secondary Accessions:
    • A7MCZ9
    • C9J921
    • C9K0J4
    • Q6NUM5
    • Q7L388
    • Q7Z4B7
    • Q9H922
    • Q9NUQ1

    Protein attributes for MYEF2 Gene

    Size:
    600 amino acids
    Molecular mass:
    64122 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH14533.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13703.1; Type=Frameshift; Positions=344; Evidence={ECO:0000305}; Sequence=BAA92579.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYEF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYEF2 Gene

Proteomics data for MYEF2 Gene at MOPED

Post-translational modifications for MYEF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys521

No data available for DME Specific Peptides for MYEF2 Gene

Domains for MYEF2 Gene

Gene Families for MYEF2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for MYEF2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MYEF2_HUMAN
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.:
    • Q9P2K5
genes like me logo Genes that share domains with MYEF2: view

Function for MYEF2 Gene

Molecular function for MYEF2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5-TTGTCC-3 of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).

Gene Ontology (GO) - Molecular Function for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MYEF2: view

Transcription Factor Targeting for MYEF2 Gene

Selected GeneGlobe predicted Target genes for MYEF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models and HOMER Transcription for MYEF2 Gene

Localization for MYEF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYEF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYEF2 Gene COMPARTMENTS Subcellular localization image for MYEF2 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8455629
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MYEF2: view

Pathways for MYEF2 Gene

genes like me logo Genes that share pathways with MYEF2: view

Gene Ontology (GO) - Biological Process for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0014902 myotube differentiation IEP 8455629
GO:0030182 neuron differentiation IEP 8455629
genes like me logo Genes that share ontologies with MYEF2: view

Transcripts for MYEF2 Gene

Unigene Clusters for MYEF2 Gene

Myelin expression factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYEF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8: -
SP9:
SP10: -

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MYEF2 Gene

GeneLoc Exon Structure for
MYEF2
ECgene alternative splicing isoforms for
MYEF2

Expression for MYEF2 Gene

mRNA expression in normal human tissues for MYEF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYEF2 Gene

SOURCE GeneReport for Unigene cluster for MYEF2 Gene Hs.6638

genes like me logo Genes that share expressions with MYEF2: view

Orthologs for MYEF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYEF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYEF2 36
  • 99.67 (n)
  • 99.33 (a)
MYEF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYEF2 36
  • 87.72 (n)
  • 87.29 (a)
MYEF2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYEF2 36
  • 96.45 (n)
  • 97.43 (a)
MYEF2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9833 37
  • 86 (a)
OneToMany
Myef2 36
  • 90.19 (n)
  • 92.05 (a)
Myef2 16
Myef2 37
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MYEF2 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYEF2 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myef2 36
  • 90.19 (n)
  • 92.05 (a)
chicken
(Gallus gallus)
Aves MYEF2 36
  • 80.73 (n)
  • 79.16 (a)
MYEF2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYEF2 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myef2 36
  • 73.55 (n)
  • 74.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9165 36
zebrafish
(Danio rerio)
Actinopterygii myef2 36
  • 66.48 (n)
  • 69.96 (a)
myef2 37
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rump 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A1.4 37
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 37
  • 22 (a)
ManyToMany
HRB1 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7224 37
  • 40 (a)
OneToMany
Species with no ortholog for MYEF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYEF2 Gene

ENSEMBL:
Gene Tree for MYEF2 (if available)
TreeFam:
Gene Tree for MYEF2 (if available)

Paralogs for MYEF2 Gene

Paralogs for MYEF2 Gene

Selected SIMAP similar genes for MYEF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYEF2: view

Variants for MYEF2 Gene

Sequence variations from dbSNP and Humsavar for MYEF2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2292710 -- 48,167,134(+) GAAAA(A/G)TGAAT intron-variant
rs2413885 -- 48,171,713(+) TTCCA(A/G)GTCAT intron-variant
rs2433358 -- 48,146,018(+) CATAA(C/T)GGAAA intron-variant
rs2433359 -- 48,147,301(+) CAAAC(A/G)GAAAG intron-variant
rs2459394 -- 48,152,551(+) TATCT(A/T)GAACT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MYEF2 Gene

Variant ID Type Subtype PubMed ID
nsv832999 CNV Gain 17160897

Relevant External Links for MYEF2 Gene

HapMap Linkage Disequilibrium report
MYEF2
Human Gene Mutation Database (HGMD)
MYEF2

Disorders for MYEF2 Gene

Relevant External Links for MYEF2

Genetic Association Database (GAD)
MYEF2
genes like me logo Genes that share disorders with MYEF2: view

No data available for UniProtKB/Swiss-Prot for MYEF2 Gene

Publications for MYEF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. (PMID: 15870273) de la Serna I.L. … Imbalzano A.N. (Mol. Cell. Biol. 2005) 3
  5. Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. (PMID: 16424906) Ohkawa Y. … Imbalzano A.N. (EMBO J. 2006) 3

Products for MYEF2 Gene

Sources for MYEF2 Gene

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