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MYEF2 Gene

protein-coding   GIFtS: 53
GCID: GC15M048434

Myelin Expression Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Expression Factor 21 2     myEF-22
MEF-22 3     Myelin Gene Expression Factor 22
MST1562 3     KIAA13413
HsT185642     MyEF-23
MSTP1562     

External Ids:    HGNC: 179401   Entrez Gene: 508042   Ensembl: ENSG000001041777   UniProtKB: Q9P2K53   

Export aliases for MYEF2 gene to outside databases

Previous GC identifers: GC15M041478 GC15M046011 GC15M046148 GC15M046219 GC15M048433 GC15M025264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYEF2 Gene:
MYEF2 (myelin expression factor 2) is a protein-coding gene. Diseases associated with MYEF2 include brain cancer, and hiv-1. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is HNRNPM.

UniProtKB/Swiss-Prot: MYEF2_HUMAN, Q9P2K5
Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element
5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYEF2 gene promoter:
         ATF-2   Olf-1   FOXD3   Nkx5-1   Meis-1b   MEF-2A   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYEF2 promoter sequence
   Search Chromatin IP Primers for MYEF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYEF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q15.1

MYEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYEF2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M048434:  view genomic region     (about GC identifiers)

Start:
48,431,625 bp from pter      End:
48,470,714 bp from pter
Size:
39,090 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYEF2_HUMAN, Q9P2K5 (See protein sequence)
Recommended Name: Myelin expression factor 2  
Size: 600 amino acids; 64122 Da
Subunit: Monomer (By similarity)
Sequence caution: Sequence=AAH14533.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAQ13703.1; Type=Frameshift; Positions=344; Sequence=BAA92579.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: A7MCZ9 C9J921 C9K0J4 Q6NUM5 Q7L388 Q7Z4B7 Q9H922 Q9NUQ1
Alternative splicing: 4 isoforms:  Q9P2K5-1   Q9P2K5-2   Q9P2K5-3   Q9P2K5-4   

Explore the universe of human proteins at neXtProt for MYEF2: NX_Q9P2K5

Explore proteomics data for MYEF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys521
  • Modification sites at PhosphoSitePlus

  • See MYEF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057216.2  
    ENSEMBL proteins: 
     ENSP00000316950   ENSP00000267836   ENSP00000452918   ENSP00000453830   ENSP00000453125  
     ENSP00000452913  

    MYEF2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MYEF2
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    Novus Biologicals MYEF2 Protein
    Novus Biologicals MYEF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYEF2

    MYEF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MYEF2
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    LSBio Antibodies in human, mouse, rat for MYEF2

    MYEF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MYEF2
    Cloud-Clone Corp. CLIAs for MYEF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9P2K5

    ProtoNet protein and cluster: Q9P2K5

    UniProtKB/Swiss-Prot: MYEF2_HUMAN, Q9P2K5
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    MYEF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYEF2_HUMAN, Q9P2K5
    Function: Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element
    5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    MYEF2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYEF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYEF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYEF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYEF2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MYEF2 (see all 333):
    ABI1,  ADAT2,  ADH5,  ADH7,  AKR1D1,  ANKAR,  ANXA8,  ANXA8L1,  ANXA8L2,  ARAP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYEF2:
    hsa-mir-26b-5p (MIRT029056), hsa-mir-92a-3p (MIRT049561), hsa-mir-21-5p (MIRT030757), hsa-mir-125b-5p (MIRT045916), hsa-mir-10a-5p (MIRT047609)

    Block miRNA regulation of human, mouse, rat MYEF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYEF2 (see all 55):
    hsa-miR-579 hsa-miR-607 hsa-miR-3658 hsa-miR-208a hsa-miR-208b hsa-miR-654-5p hsa-miR-626 hsa-miR-433
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYEF2
    Predesigned siRNA for gene silencing in human, mouse, rat MYEF2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MYEF2

    Clone
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    OriGene clones in human, mouse for MYEF2 (see all 10)
    OriGene ORF clones in mouse, rat for MYEF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYEF2 (NM_016132)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYEF2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MYEF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYEF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYEF2_HUMAN, Q9P2K5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytoskeleton2
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus ----

    MYEF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYEF2 About    
    See pathways by source

    SuperPathContained pathways About
    1TFs Regulate miRNAs related to cardiac hypertrophy
    TFs Regulate miRNAs related to cardiac hypertrophy
    2Physiological and Pathological Hypertrophy of the Heart
    Physiological and Pathological Hypertrophy of the Heart
    3MicroRNAs in cardiomyocyte hypertrophy
    MicroRNAs in cardiomyocyte hypertrophy


    3 BioSystems Pathways for MYEF2
        MicroRNAs in cardiomyocyte hypertrophy
    Physiological and Pathological Hypertrophy of the Heart
    TFs Regulate miRNAs related to cardiac hypertrophy


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYEF2
    Interactions:

        GeneGlobe Interaction Network for MYEF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYEF2 (Q9P2K53 ENSP000003169504) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPARGC1AQ9UBK23, ENSP000002648674I2D: score=1 STRING: ENSP00000264867
    RAPSNQ137023, ENSP000002988544I2D: score=1 STRING: ENSP00000298854
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    ATXN1P542533, ENSP000002447694I2D: score=1 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0014902myotube differentiation IEP8455629
    GO:0030182neuron differentiation IEP8455629

    MYEF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYEF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYEF2 gene: 
    NM_016132.3  

    Unigene Cluster for MYEF2:

    Myelin expression factor 2
    Hs.6638  [show with all ESTs]
    Unigene Representative Sequence: NM_016132
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324324(uc001zwh.4 uc001zwi.4 uc001zwj.4) ENST00000558289(uc001zwg.4)
    ENST00000560530 ENST00000267836 ENST00000560172 ENST00000559057 ENST00000558395
    ENST00000560513 ENST00000561301 ENST00000561351(uc001zwl.3) ENST00000557868
    ENST00000559862 ENST00000560157 ENST00000561151
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYEF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYEF2 (see all 55):
    hsa-miR-579 hsa-miR-607 hsa-miR-3658 hsa-miR-208a hsa-miR-208b hsa-miR-654-5p hsa-miR-626 hsa-miR-433
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYEF2
    Predesigned siRNA for gene silencing in human, mouse, rat MYEF2
    Clone
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    OriGene clones in human, mouse for MYEF2 (see all 10)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYEF2 (NM_016132)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYEF2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYEF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYEF2
      QuantiTect SYBR Green Assays in human, mouse, rat MYEF2
      QuantiFast Probe-based Assays in human, mouse, rat MYEF2

    Additional mRNA sequence: 

    AB037762.1 AF106685.1 AF190159.1 AK002075.1 AK023133.1 AK027316.1 BC014533.1 BC068523.1 
    BC131786.1 BC152420.1 BC152451.1 BX647197.1 

    13 DOTS entries:

    DT.409979  DT.112605  DT.100788905  DT.91741900  DT.99956652  DT.121018809  DT.100694921  DT.121018815 
    DT.121018823  DT.121018826  DT.91996498  DT.97785888  DT.95204503 

    Selected AceView cDNA sequences (see all 156):

    BE467731 H29956 BM310979 AA974356 AL699173 BX116620 AI467808 CR596492 
    CB178031 BM555728 AI908963 AI697679 CK824588 AI338597 BE220919 AW590660 
    AI458750 AA360072 AI479260 CB045286 AW263476 AV699696 BF447821 BE467826 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYEF2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                      -     -                                   -                 -                                                         
    SP2:                                      -     -                                   -                                                                           
    SP3:                                                                                                  -                                   -                     
    SP4:                                                                                                                                      -                     
    SP5:              -                       -     -                                                                                                               

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MYEF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYEF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATACCAAG
    MYEF2 Expression
    About this image

    MYEF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYEF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6638
        Custom PCR Arrays for MYEF2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYEF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYEF2
    QuantiTect SYBR Green Assays in human, mouse, rat MYEF2
    QuantiFast Probe-based Assays in human, mouse, rat MYEF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYEF2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myef21 , 5 myelin basic protein expression factor 2, repressor1, 5 90.19(n)1
    92.05(a)1
      2 (61.16 cM)5
    178761  NM_001162417.11  NP_001155889.11 
     1250846285 
    chicken
    (Gallus gallus)
    Aves MYEF21 myelin expression factor 2 80.73(n)
    79.16(a)
      415432  NM_001012768.2  NP_001012786.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYEF26
    myelin expression factor 2
    70(a)
    1 ↔ 1
    GL343561.1(319839-338146)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myef21 myelin expression factor 2 73.55(n)
    74.41(a)
      548789  NM_001016035.2  NP_001016035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myef21 myelin expression factor 2 66.48(n)
    69.96(a)
      641483  NM_001037423.1  NP_001032500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rump6
    rumpelstiltskin
    28(a)
    1 → many
    3R(5331575-5336087)
    worm
    (Caenorhabditis elegans)
    Secernentea C25A1.46
    Protein C25A1.4 (C25A1.4) mRNA, complete cds
    34(a)
    1 → many
    I(10169636-10172645) WBGene00007706
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GBP26
    HRB16
    Poly(A+) RNA-binding protein, involved in the expo...
    Poly(A+) RNA-binding protein, involved in the expo...
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    III(102075-103358) YCL011C
    XIV(622915-624621) YNL004W


    ENSEMBL Gene Tree for MYEF2 (if available)
    TreeFam Gene Tree for MYEF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYEF2 gene
    HNRNPM2  
    8 SIMAP similar genes for MYEF2 using alignment to 3 protein entries:     MYEF2_HUMAN (see all proteins):
    DKFZp547H118    HNRNPM    HNRPM    PABPC4L    CELF3    ORF
    PABPC4    PABPC1

    MYEF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYEF2 (see all 539)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006935721,2
    --28501164(+) CAAGCA/GAACAT 2 R C mis10--------
    rs1457294431,2
    F--28501189(+) CTGATT/CTTTAT 2 /K syn11Minor allele frequency- C:0.00NA 4548
    rs1892434051,2
    --28501395(+) ATTGTA/GATAAT 1 -- int10--------
    rs1472045591,2
    C--28501545(+) TTAATA/GTATTT 1 -- int10--------
    rs1818874281,2
    --28501569(+) TCCCTA/GATTCC 1 -- int10--------
    rs1482405571,2
    --28501919(+) GAAGAA/GATAGC 1 -- int10--------
    rs1865266001,2
    --28501976(+) ATCAGA/GGAAGC 1 -- int10--------
    rs1413804771,2
    C--28502061(+) ATTTGA/GAGTAA 1 -- int10--------
    rs798780271,2
    C,F--28502143(+) AAAGGG/AGGAGT 1 -- int11Minor allele frequency- A:0.20WA 118
    rs1507892701,2
    C--28502236(+) AGGTCA/GTAAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MYEF2 (48431625 - 48470714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYEF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832999CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYEF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    3 diseases for MYEF2:    
    About MalaCards
    brain cancer    hiv-1    neuronitis


    MYEF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYEF2

    Export disorders for MYEF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYEF2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MYEF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    8. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. (PubMed id 21532573)1 Engelen E....Poot R.A. (Nat. Genet. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 50804 HGNC: 17940 AceView: MYEF2 Ensembl:ENSG00000104177 euGenes: HUgn50804
    ECgene: MYEF2 H-InvDB: MYEF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1341

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYEF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYEF2 gene:
    Search GeneIP for patents involving MYEF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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