Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYEF2 Gene

Aliases for MYEF2 Gene

  • Myelin Expression Factor 2 2 3 5
  • MyEF-2 3 4
  • MST156 3 4
  • MEF-2 3 4
  • Myelin Gene Expression Factor 2 3
  • HsT18564 3
  • KIAA1341 4
  • MSTP156 3

External Ids for MYEF2 Gene

Previous GeneCards Identifiers for MYEF2 Gene

  • GC15M041478
  • GC15M046011
  • GC15M046148
  • GC15M046219
  • GC15M048433
  • GC15M025264
  • GC15M048434

Summaries for MYEF2 Gene

GeneCards Summary for MYEF2 Gene

MYEF2 (Myelin Expression Factor 2) is a Protein Coding gene. Diseases associated with MYEF2 include Loeys-Dietz Syndrome. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Physiological and Pathological Hypertrophy of the Heart. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPM.

UniProtKB/Swiss-Prot for MYEF2 Gene

  • Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5-TTGTCC-3 of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYEF2 Gene

Genomics for MYEF2 Gene

Regulatory Elements for MYEF2 Gene

Enhancers for MYEF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G047687 0.3 FANTOM5 1.5 +491.3 491282 0.3 MYEF2 RPL7AP62 LOC105370804
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYEF2 on UCSC Golden Path with GeneCards custom track

Promoters for MYEF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076151 517 1600 SIN3A BRCA1 ZNF48 SCRT2 RCOR1 RELB IKZF2 HCFC1 YY2 CBFB

Genomic Location for MYEF2 Gene

Chromosome:
15
Start:
48,134,631 bp from pter
End:
48,178,517 bp from pter
Size:
43,887 bases
Orientation:
Minus strand

Genomic View for MYEF2 Gene

Genes around MYEF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYEF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYEF2 Gene

Proteins for MYEF2 Gene

  • Protein details for MYEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K5-MYEF2_HUMAN
    Recommended name:
    Myelin expression factor 2
    Protein Accession:
    Q9P2K5
    Secondary Accessions:
    • A7MCZ9
    • C9J921
    • C9K0J4
    • Q6NUM5
    • Q7L388
    • Q7Z4B7
    • Q9H922
    • Q9NUQ1

    Protein attributes for MYEF2 Gene

    Size:
    600 amino acids
    Molecular mass:
    64122 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH14533.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13703.1; Type=Frameshift; Positions=344; Evidence={ECO:0000305}; Sequence=BAA92579.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYEF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYEF2 Gene

Post-translational modifications for MYEF2 Gene

  • Ubiquitination at posLast=521521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYEF2 Gene

Domains & Families for MYEF2 Gene

Gene Families for MYEF2 Gene

Protein Domains for MYEF2 Gene

Suggested Antigen Peptide Sequences for MYEF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYEF2: view

No data available for UniProtKB/Swiss-Prot for MYEF2 Gene

Function for MYEF2 Gene

Molecular function for MYEF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5-TTGTCC-3 of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).

Gene Ontology (GO) - Molecular Function for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0003723 RNA binding IDA,IEA 22681889
genes like me logo Genes that share ontologies with MYEF2: view
genes like me logo Genes that share phenotypes with MYEF2: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for MYEF2 Gene

Selected GeneGlobe predicted Target genes for MYEF2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYEF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for MYEF2 Gene

Localization for MYEF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYEF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYEF2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 8455629
genes like me logo Genes that share ontologies with MYEF2: view

Pathways & Interactions for MYEF2 Gene

genes like me logo Genes that share pathways with MYEF2: view

Gene Ontology (GO) - Biological Process for MYEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0014902 myotube differentiation IEP 8455629
GO:0030182 neuron differentiation IEP 8455629
genes like me logo Genes that share ontologies with MYEF2: view

No data available for SIGNOR curated interactions for MYEF2 Gene

Drugs & Compounds for MYEF2 Gene

No Compound Related Data Available

Transcripts for MYEF2 Gene

Unigene Clusters for MYEF2 Gene

Myelin expression factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYEF2

Alternative Splicing Database (ASD) splice patterns (SP) for MYEF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8: -
SP9:
SP10: -

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MYEF2 Gene

GeneLoc Exon Structure for
MYEF2
ECgene alternative splicing isoforms for
MYEF2

Expression for MYEF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYEF2 Gene

Protein differential expression in normal tissues from HIPED for MYEF2 Gene

This gene is overexpressed in Fetal Brain (17.2), Amniocyte (10.9), and Retina (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYEF2 Gene



Protein tissue co-expression partners for MYEF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYEF2 Gene:

MYEF2

SOURCE GeneReport for Unigene cluster for MYEF2 Gene:

Hs.6638

Evidence on tissue expression from TISSUES for MYEF2 Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MYEF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYEF2 Gene

Orthologs for MYEF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYEF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYEF2 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia MYEF2 34 35
  • 96.45 (n)
mouse
(Mus musculus)
Mammalia Myef2 34 16 35
  • 90.19 (n)
Gm9833 35
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myef2 34
  • 90.19 (n)
cow
(Bos Taurus)
Mammalia MYEF2 34 35
  • 87.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYEF2 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYEF2 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYEF2 34 35
  • 80.73 (n)
lizard
(Anolis carolinensis)
Reptilia MYEF2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myef2 34
  • 73.55 (n)
zebrafish
(Danio rerio)
Actinopterygii myef2 34 35
  • 66.48 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9165 34
fruit fly
(Drosophila melanogaster)
Insecta rump 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A1.4 35
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GBP2 35
  • 22 (a)
ManyToMany
HRB1 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7224 35
  • 40 (a)
OneToMany
Species where no ortholog for MYEF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYEF2 Gene

ENSEMBL:
Gene Tree for MYEF2 (if available)
TreeFam:
Gene Tree for MYEF2 (if available)

Paralogs for MYEF2 Gene

Paralogs for MYEF2 Gene

(8) SIMAP similar genes for MYEF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYEF2: view

Variants for MYEF2 Gene

Sequence variations from dbSNP and Humsavar for MYEF2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs886037643 Pathogenic 48,136,683(+) TGTAG(A/G)TATGA reference, utr-variant-3-prime, stop-gained
rs886037644 Pathogenic 48,142,209(+) TTTTT(-/T)AGCAG reference, utr-variant-3-prime, frameshift-variant
rs1057517995 Likely pathogenic 48,134,940(+) ATTAG(A/T)GCAGC reference, missense, utr-variant-3-prime
rs138902406 Uncertain significance 48,134,928(+) GCAGC(A/G)TACAC reference, synonymous-codon, utr-variant-3-prime
rs146726548 Uncertain significance 48,142,290(+) TACAT(C/T)ATCAG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYEF2 Gene

Variant ID Type Subtype PubMed ID
nsv569338 CNV loss 21841781
nsv832999 CNV gain 17160897

Variation tolerance for MYEF2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYEF2 Gene

Human Gene Mutation Database (HGMD)
MYEF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYEF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYEF2 Gene

Disorders for MYEF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYEF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
loeys-dietz syndrome
  • loeys-dietz aortic aneurysm syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MYEF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYEF2

Genetic Association Database (GAD)
MYEF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYEF2
genes like me logo Genes that share disorders with MYEF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYEF2 Gene

Publications for MYEF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for MYEF2 Gene

  • Addgene plasmids for MYEF2

Sources for MYEF2 Gene

Content
Loading form....