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Aliases for MYDGF Gene

Aliases for MYDGF Gene

  • Myeloid Derived Growth Factor 2 3 5
  • Stromal Cell-Derived Growth Factor SF20 3 4
  • Interleukin 27 Working Designation 2 3
  • Interleukin-25 3 4
  • C19orf10 3 4
  • IL25 3 4
  • Chromosome 19 Open Reading Frame 10 2
  • Myeloid-Derived Growth Factor 3
  • UPF0556 Protein C19orf10 3
  • EUROIMAGE1875335 3
  • R33729_1 3
  • IL-25 4
  • IL27w 3
  • SF20 3
  • IL27 3

External Ids for MYDGF Gene

Previous HGNC Symbols for MYDGF Gene

  • IL27
  • IL27w
  • C19orf10

Summaries for MYDGF Gene

Entrez Gene Summary for MYDGF Gene

  • The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYDGF Gene

MYDGF (Myeloid Derived Growth Factor) is a Protein Coding gene. Diseases associated with MYDGF include Myocardial Infarction. Among its related pathways are Metabolism of proteins and Unfolded Protein Response (UPR).

UniProtKB/Swiss-Prot for MYDGF Gene

  • Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYDGF Gene

Genomics for MYDGF Gene

Regulatory Elements for MYDGF Gene

Enhancers for MYDGF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004644 1.2 Ensembl ENCODE 18 +23.5 23531 4.4 BCOR CTCF ZMYM3 EBF1 POLR2A ADNP EED ZNF600 KLF8 SMARCA5 MYDGF DPP9 TNFAIP8L1 GC19M004643 PIR47904
GH19F004704 1.1 ENCODE 8.7 -34.9 -34887 2.2 ELF3 MLX ARID4B DMAP1 ZSCAN9 DNMT3B ZNF48 RARA YY1 MIXL1 MYDGF LOC105372250 GC19M004658
GH19F004692 0.6 Ensembl ENCODE 8.4 -24.7 -24719 5.8 RAD21 ZBTB40 YY1 ZNF121 SCRT2 FOS EGR2 ZNF263 NFYA USF2 MYDGF GC19M004658 LOC105372250
GH19F004668 0.9 ENCODE 8 0.0 -25 2.9 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS LOC100287614 ENSG00000267769 ENSG00000267030 SAFB ENSG00000268670 MYDGF DPP9-AS1
GH19F005155 1 Ensembl ENCODE 5.8 -485.7 -485665 1.7 ZFHX2 POLR2A ZBTB40 EGR2 ZNRF4 MYDGF GC19P005167 PIR36975
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYDGF on UCSC Golden Path with GeneCards custom track

Promoters for MYDGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342317 403 1601 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for MYDGF Gene

Chromosome:
19
Start:
4,641,374 bp from pter
End:
4,670,403 bp from pter
Size:
29,030 bases
Orientation:
Minus strand

Genomic View for MYDGF Gene

Genes around MYDGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYDGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYDGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYDGF Gene

Proteins for MYDGF Gene

  • Protein details for MYDGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H8-MYDGF_HUMAN
    Recommended name:
    Myeloid-derived growth factor
    Protein Accession:
    Q969H8
    Secondary Accessions:
    • D6W628
    • O75256
    • O75272
    • Q9BTK7
    • Q9NP69

    Protein attributes for MYDGF Gene

    Size:
    173 amino acids
    Molecular mass:
    18795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MYDGF Gene

Post-translational modifications for MYDGF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYDGF Gene

No data available for DME Specific Peptides for MYDGF Gene

Domains & Families for MYDGF Gene

Protein Domains for MYDGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYDGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969H8

UniProtKB/Swiss-Prot:

MYDGF_HUMAN :
  • Belongs to the MYDGF family.
Family:
  • Belongs to the MYDGF family.
genes like me logo Genes that share domains with MYDGF: view

No data available for Gene Families for MYDGF Gene

Function for MYDGF Gene

Molecular function for MYDGF Gene

UniProtKB/Swiss-Prot Function:
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to myocardial infarction (MI).

Gene Ontology (GO) - Molecular Function for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MYDGF: view
genes like me logo Genes that share phenotypes with MYDGF: view

Animal Models for MYDGF Gene

MGI Knock Outs for MYDGF:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYDGF

miRNA for MYDGF Gene

miRTarBase miRNAs that target MYDGF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYDGF Gene

Localization for MYDGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYDGF Gene

Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Note=Secreted into blood plasma. {ECO:0000269 PubMed:25581518}.

Gene Ontology (GO) - Cellular Components for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 25581518
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYDGF: view

No data available for Subcellular locations from COMPARTMENTS for MYDGF Gene

Pathways & Interactions for MYDGF Gene

genes like me logo Genes that share pathways with MYDGF: view

Gene Ontology (GO) - Biological Process for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001938 positive regulation of endothelial cell proliferation IDA 25581518
GO:0006915 apoptotic process IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA,ISS --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for SIGNOR curated interactions for MYDGF Gene

Drugs & Compounds for MYDGF Gene

(1) Drugs for MYDGF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYDGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYDGF: view

Transcripts for MYDGF Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYDGF Gene

No ASD Table

Relevant External Links for MYDGF Gene

GeneLoc Exon Structure for
MYDGF
ECgene alternative splicing isoforms for
MYDGF

Expression for MYDGF Gene

mRNA expression in normal human tissues for MYDGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYDGF Gene

This gene is overexpressed in Oral epithelium (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYDGF Gene



Protein tissue co-expression partners for MYDGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYDGF Gene:

MYDGF

mRNA Expression by UniProt/SwissProt for MYDGF Gene:

Q969H8-MYDGF_HUMAN
Tissue specificity: Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
genes like me logo Genes that share expression patterns with MYDGF: view

Primer Products

No data available for mRNA differential expression in normal tissues for MYDGF Gene

Orthologs for MYDGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYDGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19ORF10 35
  • 100 (a)
OneToOne
C19H19orf10 34
  • 90.75 (n)
dog
(Canis familiaris)
Mammalia C19orf10 35
  • 90 (a)
OneToOne
C20H19orf10 34
  • 89.21 (n)
cow
(Bos Taurus)
Mammalia C7H19orf10 34 35
  • 88.44 (n)
mouse
(Mus musculus)
Mammalia D17Wsu104e 34 35
  • 84.04 (n)
Mydgf 16
rat
(Rattus norvegicus)
Mammalia LOC501282 34
  • 80 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf10 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf10 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF10 34 35
  • 68.57 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf10 34
  • 61.43 (n)
Str.16428 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16799 34
zebrafish
(Danio rerio)
Actinopterygii zgc:92871 34
  • 61.44 (n)
C22H19orf10 (1 of 2) 35
  • 53 (a)
OneToMany
C22H19orf10 (2 of 2) 35
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10031 34
Species where no ortholog for MYDGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYDGF Gene

ENSEMBL:
Gene Tree for MYDGF (if available)
TreeFam:
Gene Tree for MYDGF (if available)

Paralogs for MYDGF Gene

No data available for Paralogs for MYDGF Gene

Variants for MYDGF Gene

Sequence variations from dbSNP and Humsavar for MYDGF Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401322 -- 4,670,857(+) gcagt(A/G)gcgcg upstream-variant-2KB
rs10401515 -- 4,670,224(+) GCCAC(C/G)GTCGT reference, synonymous-codon
rs10403046 -- 4,670,956(+) accac(C/G)cctgg upstream-variant-2KB
rs10408340 -- 4,669,787(+) GATTT(C/T)CTTCA intron-variant
rs10409369 -- 4,659,473(+) cccgc(C/T)tcgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYDGF Gene

Variant ID Type Subtype PubMed ID
esv2677201 CNV deletion 23128226
esv2718027 CNV deletion 23290073
esv2718030 CNV deletion 23290073
esv29521 CNV gain 19812545
esv3643508 CNV loss 21293372
nsv1062709 CNV loss 25217958
nsv1072849 CNV deletion 25765185
nsv428361 CNV loss 18775914
nsv578450 CNV gain 21841781
nsv578451 CNV loss 21841781
nsv833721 CNV loss 17160897
nsv953950 CNV deletion 24416366

Variation tolerance for MYDGF Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYDGF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYDGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYDGF Gene

Disorders for MYDGF Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYDGF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
- elite association - COSMIC cancer census association via MalaCards
Search MYDGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYDGF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYDGF
genes like me logo Genes that share disorders with MYDGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYDGF Gene

Publications for MYDGF Gene

  1. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. (PMID: 25581518) Korf-Klingebiel M. … Wollert K.C. (Nat. Med. 2015) 2 3 4 64
  2. The identification and characterization of a novel protein, c19orf10, in the synovium. (PMID: 17362502) Weiler T. … Wilkins J.A. (Arthritis Res. Ther. 2007) 2 3 4 64
  3. Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. (PMID: 21128247) Sunagozaka H. … Kaneko S. (Int. J. Cancer 2011) 2 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MYDGF Gene

Sources for MYDGF Gene

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