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Aliases for MYDGF Gene

Aliases for MYDGF Gene

  • Myeloid-Derived Growth Factor 2 3 5
  • Stromal Cell-Derived Growth Factor SF20 3 4
  • Interleukin 27 Working Designation 2 3
  • Interleukin-25 3 4
  • C19orf10 3 4
  • IL25 3 4
  • Chromosome 19 Open Reading Frame 10 2
  • UPF0556 Protein C19orf10 3
  • EUROIMAGE1875335 3
  • Interleukin 25 3
  • R33729_1 3
  • IL-25 4
  • IL27w 3
  • IL27 3
  • SF20 3

External Ids for MYDGF Gene

Previous HGNC Symbols for MYDGF Gene

  • IL27
  • IL27w
  • C19orf10

Summaries for MYDGF Gene

Entrez Gene Summary for MYDGF Gene

  • The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYDGF Gene

MYDGF (Myeloid-Derived Growth Factor) is a Protein Coding gene. Diseases associated with MYDGF include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment and Myocardial Infarction. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for MYDGF Gene

  • Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYDGF Gene

Genomics for MYDGF Gene

Regulatory Elements for MYDGF Gene

Enhancers for MYDGF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYDGF on UCSC Golden Path with GeneCards custom track

Promoters for MYDGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYDGF on UCSC Golden Path with GeneCards custom track

Genomic Location for MYDGF Gene

Chromosome:
19
Start:
4,641,374 bp from pter
End:
4,670,403 bp from pter
Size:
29,030 bases
Orientation:
Minus strand

Genomic View for MYDGF Gene

Genes around MYDGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYDGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYDGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYDGF Gene

Proteins for MYDGF Gene

  • Protein details for MYDGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H8-MYDGF_HUMAN
    Recommended name:
    Myeloid-derived growth factor
    Protein Accession:
    Q969H8
    Secondary Accessions:
    • D6W628
    • O75256
    • O75272
    • Q9BTK7
    • Q9NP69

    Protein attributes for MYDGF Gene

    Size:
    173 amino acids
    Molecular mass:
    18795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MYDGF Gene

Proteomics data for MYDGF Gene at MOPED

Post-translational modifications for MYDGF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYDGF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYDGF Gene

Domains & Families for MYDGF Gene

Protein Domains for MYDGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYDGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969H8

UniProtKB/Swiss-Prot:

MYDGF_HUMAN :
  • Belongs to the MYDGF family.
Family:
  • Belongs to the MYDGF family.
genes like me logo Genes that share domains with MYDGF: view

No data available for Gene Families for MYDGF Gene

Function for MYDGF Gene

Molecular function for MYDGF Gene

UniProtKB/Swiss-Prot Function:
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to myocardial infarction (MI).
genes like me logo Genes that share phenotypes with MYDGF: view

Animal Models for MYDGF Gene

MGI Knock Outs for MYDGF:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYDGF

miRNA for MYDGF Gene

miRTarBase miRNAs that target MYDGF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYDGF Gene

Localization for MYDGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYDGF Gene

Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Note=Secreted into blood plasma. {ECO:0000269 PubMed:25581518}.

Gene Ontology (GO) - Cellular Components for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for Subcellular locations from COMPARTMENTS for MYDGF Gene

Pathways & Interactions for MYDGF Gene

genes like me logo Genes that share pathways with MYDGF: view

Gene Ontology (GO) - Biological Process for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001938 positive regulation of endothelial cell proliferation IEA,IDA 25581518
GO:0006915 apoptotic process IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA,ISS --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for SIGNOR curated interactions for MYDGF Gene

Drugs & Compounds for MYDGF Gene

(1) Drugs for MYDGF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYDGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYDGF: view

Transcripts for MYDGF Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MYDGF Gene

No ASD Table

Relevant External Links for MYDGF Gene

GeneLoc Exon Structure for
MYDGF
ECgene alternative splicing isoforms for
MYDGF

Expression for MYDGF Gene

mRNA expression in normal human tissues for MYDGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYDGF Gene

This gene is overexpressed in Oral epithelium (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYDGF Gene



mRNA Expression by UniProt/SwissProt for MYDGF Gene

Q969H8-MYDGF_HUMAN
Tissue specificity: Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
genes like me logo Genes that share expression patterns with MYDGF: view

Protein tissue co-expression partners for MYDGF Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for MYDGF Gene

Orthologs for MYDGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYDGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7H19orf10 35
  • 88.44 (n)
  • 89.02 (a)
C7H19orf10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf10 35
  • 89.21 (n)
  • 90.17 (a)
C19orf10 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu104e 35
  • 84.04 (n)
  • 87.88 (a)
Mydgf 16
D17Wsu104e 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf10 35
  • 90.75 (n)
  • 89.02 (a)
C19ORF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC501282 35
  • 80 (n)
  • 80.61 (a)
oppossum
(Monodelphis domestica)
Mammalia C19orf10 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf10 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF10 35
  • 68.57 (n)
  • 66.43 (a)
C28H19ORF10 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf10 35
  • 61.43 (n)
  • 57.86 (a)
Str.16428 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16799 35
zebrafish
(Danio rerio)
Actinopterygii zgc:92871 35
  • 61.44 (n)
  • 59.7 (a)
C22H19orf10 (1 of 2) 36
  • 53 (a)
OneToMany
C22H19orf10 (2 of 2) 36
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10031 35
Species with no ortholog for MYDGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYDGF Gene

ENSEMBL:
Gene Tree for MYDGF (if available)
TreeFam:
Gene Tree for MYDGF (if available)

Paralogs for MYDGF Gene

No data available for Paralogs for MYDGF Gene

Variants for MYDGF Gene

Sequence variations from dbSNP and Humsavar for MYDGF Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2270090 - 4,670,301(+) CGCGC(C/G)GACGC reference, missense
rs758325 -- 4,659,652(+) CCACC(A/G)CGCCC intron-variant
rs7507910 -- 4,672,276(+) atatt(A/C)atata upstream-variant-2KB
rs7508299 -- 4,672,396(+) attca(C/T)atata upstream-variant-2KB
rs8101903 -- 4,671,568(+) CCTAA(A/G)ATGGG upstream-variant-2KB

Variation tolerance for MYDGF Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MYDGF Gene

Disorders for MYDGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYDGF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
myocardial infarction
  • myocardial infarction, protection against
- elite association - COSMIC cancer census association via MalaCards
Search MYDGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYDGF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYDGF
genes like me logo Genes that share disorders with MYDGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYDGF Gene

Publications for MYDGF Gene

  1. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. (PMID: 25581518) Korf-Klingebiel M. … Wollert K.C. (Nat. Med. 2015) 2 3 4 67
  2. Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. (PMID: 21128247) Sunagozaka H. … Kaneko S. (Int. J. Cancer 2011) 2 3
  3. The identification and characterization of a novel protein, c19orf10, in the synovium. (PMID: 17362502) Weiler T. … Wilkins J.A. (Arthritis Res. Ther. 2007) 2 3
  4. A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2. (PMID: 24583282) Nicholson J. … Hupp T.R. (Cell. Signal. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for MYDGF Gene

Sources for MYDGF Gene

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