Aliases for MYDGF Gene
External Ids for MYDGF Gene
Previous HGNC Symbols for MYDGF Gene
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYDGF Gene
MYDGF (Myeloid-Derived Growth Factor) is a Protein Coding gene. Diseases associated with MYDGF include major depressive disorder and accelerated response to antidepressant drug treatment and myocardial infarction. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification.
UniProtKB/Swiss-Prot for MYDGF Gene
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).