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Aliases for MYDGF Gene

Aliases for MYDGF Gene

  • Myeloid-Derived Growth Factor 2 3
  • C19orf10 3 4 6
  • IL25 3 4 6
  • Stromal Cell-Derived Growth Factor SF20 3 4
  • Interleukin 27 Working Designation 2 3
  • Interleukin-25 3 4
  • SF20 3 6
  • Chromosome 19 Open Reading Frame 10 2
  • UPF0556 Protein C19orf10 3
  • EUROIMAGE1875335 3
  • Interleukin 25 3
  • R33729_1 3
  • IL-25 4
  • IL27w 3
  • IL27 3

External Ids for MYDGF Gene

Previous HGNC Symbols for MYDGF Gene

  • IL27
  • IL27w
  • C19orf10

Summaries for MYDGF Gene

Entrez Gene Summary for MYDGF Gene

  • The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYDGF Gene

MYDGF (Myeloid-Derived Growth Factor) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response.

UniProtKB/Swiss-Prot for MYDGF Gene

  • Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYDGF Gene

Genomics for MYDGF Gene

Genomic Location for MYDGF Gene

Start:
4,641,374 bp from pter
End:
4,670,403 bp from pter
Size:
29,030 bases
Orientation:
Minus strand

Genomic View for MYDGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYDGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYDGF Gene

No data available for Regulatory Elements for MYDGF Gene

Proteins for MYDGF Gene

  • Protein details for MYDGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H8-MYDGF_HUMAN
    Recommended name:
    Myeloid-derived growth factor
    Protein Accession:
    Q969H8
    Secondary Accessions:
    • D6W628
    • O75256
    • O75272
    • Q9BTK7
    • Q9NP69

    Protein attributes for MYDGF Gene

    Size:
    173 amino acids
    Molecular mass:
    18795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MYDGF Gene

Proteomics data for MYDGF Gene at MOPED

Post-translational modifications for MYDGF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYDGF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYDGF Gene

Domains for MYDGF Gene

Protein Domains for MYDGF Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969H8

UniProtKB/Swiss-Prot:

MYDGF_HUMAN :
  • Q969H8
Family:
  • Belongs to the MYDGF family.
genes like me logo Genes that share domains with MYDGF: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MYDGF Gene

Function for MYDGF Gene

Molecular function for MYDGF Gene

UniProtKB/Swiss-Prot Function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
UniProtKB/Swiss-Prot Induction: Up-regulated in response to myocardial infarction (MI).

Gene Ontology (GO) - Molecular Function for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MYDGF: view

miRNA for MYDGF Gene

miRTarBase miRNAs that target MYDGF

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYDGF Gene

Localization for MYDGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYDGF Gene

Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Note=Secreted into blood plasma. {ECO:0000269 PubMed:25581518}.

Gene Ontology (GO) - Cellular Components for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25581518
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYDGF: view

No data available for Subcellular locations from COMPARTMENTS for MYDGF Gene

Pathways for MYDGF Gene

genes like me logo Genes that share pathways with MYDGF: view

Pathways by source for MYDGF Gene

Gene Ontology (GO) - Biological Process for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001938 positive regulation of endothelial cell proliferation IDA 25581518
GO:0006915 apoptotic process IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
genes like me logo Genes that share ontologies with MYDGF: view

Compounds for MYDGF Gene

(3) Novoseek inferred chemical compound relationships for MYDGF Gene

Compound -log(P) Hits PubMed IDs
sdf 1 75.4 2
rantes 45.5 3
calcium 0 1
genes like me logo Genes that share compounds with MYDGF: view

Transcripts for MYDGF Gene

mRNA/cDNA for MYDGF Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MYDGF Gene

No ASD Table

Relevant External Links for MYDGF Gene

GeneLoc Exon Structure for
MYDGF
ECgene alternative splicing isoforms for
MYDGF

Expression for MYDGF Gene

mRNA expression in normal human tissues for MYDGF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYDGF Gene

mRNA Expression by UniProt/SwissProt for MYDGF Gene

Q969H8-MYDGF_HUMAN
Tissue specificity: Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
genes like me logo Genes that share expressions with MYDGF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MYDGF Gene

Orthologs for MYDGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYDGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf10 35
  • 90.75 (n)
  • 89.02 (a)
C19ORF10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf10 35
  • 88.44 (n)
  • 89.02 (a)
C7H19orf10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19orf10 36
  • 90 (a)
OneToOne
C20H19orf10 35
  • 89.21 (n)
  • 90.17 (a)
mouse
(Mus musculus)
Mammalia D17Wsu104e 35
  • 84.04 (n)
  • 87.88 (a)
D17Wsu104e 16
D17Wsu104e 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf10 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf10 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC501282 35
  • 80 (n)
  • 80.61 (a)
chicken
(Gallus gallus)
Aves C28H19ORF10 35
  • 68.57 (n)
  • 66.43 (a)
C28H19ORF10 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16799 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf10 35
  • 61.43 (n)
  • 57.86 (a)
Str.16428 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10031 35
zebrafish
(Danio rerio)
Actinopterygii C22H19orf10 (1 of 2) 36
  • 53 (a)
OneToMany
C22H19orf10 (2 of 2) 36
  • 53 (a)
OneToMany
zgc:92871 35
  • 61.44 (n)
  • 59.7 (a)
Species with no ortholog for MYDGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYDGF Gene

ENSEMBL:
Gene Tree for MYDGF (if available)
TreeFam:
Gene Tree for MYDGF (if available)

Paralogs for MYDGF Gene

No data available for Paralogs for MYDGF Gene

Variants for MYDGF Gene

Sequence variations from dbSNP and Humsavar for MYDGF Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11148 -- 4,657,945(-) CTGTG(G/T)CCCTG utr-variant-3-prime
rs12683 -- 4,658,035(-) GTGAT(A/C/T)GTGGC synonymous-codon, reference
rs758325 -- 4,659,652(+) CCACC(A/G)CGCCC intron-variant
rs1127798 -- 4,670,293(-) GCGAC(G/T)TTGTG frameshift-variant
rs2074966 -- 4,670,494(+) CTTTG(C/T)CGAGG upstream-variant-2KB

Relevant External Links for MYDGF Gene

HapMap Linkage Disequilibrium report
MYDGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYDGF Gene

Disorders for MYDGF Gene

(7) Novoseek inferred disease relationships for MYDGF Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 26.5 4
inflammation 23.4 2
benign prostatic hyperplasia 14.8 1
virus infection 0 1
necrosis 0 1
genes like me logo Genes that share disorders with MYDGF: view

No data available for UniProtKB/Swiss-Prot for MYDGF Gene

Publications for MYDGF Gene

  1. The identification and characterization of a novel protein, c19orf10, in the synovium. (PMID: 17362502) Weiler T. … Wilkins J.A. (Arthritis Res. Ther. 2007) 2 3 4
  2. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. (PMID: 25581518) Korf-Klingebiel M. … Wollert K.C. (Nat. Med. 2015) 2 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. (PMID: 21128247) Sunagozaka H. … Kaneko S. (Int. J. Cancer 2011) 2 3

Products for MYDGF Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MYDGF
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MYDGF
    • Block miRNA regulation of MYDGF using miScript Target Protectors

    Sources for MYDGF Gene

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