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Aliases for MYDGF Gene

Aliases for MYDGF Gene

  • Myeloid-Derived Growth Factor 2 3
  • Stromal Cell-Derived Growth Factor SF20 3 4
  • Interleukin 27 Working Designation 2 3
  • Interleukin-25 3 4
  • C19orf10 3 4
  • IL25 3 4
  • Chromosome 19 Open Reading Frame 10 2
  • UPF0556 Protein C19orf10 3
  • EUROIMAGE1875335 3
  • Interleukin 25 3
  • R33729_1 3
  • IL-25 4
  • IL27w 3
  • IL27 3
  • SF20 3

External Ids for MYDGF Gene

Previous HGNC Symbols for MYDGF Gene

  • IL27
  • IL27w
  • C19orf10

Summaries for MYDGF Gene

Entrez Gene Summary for MYDGF Gene

  • The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYDGF Gene

MYDGF (Myeloid-Derived Growth Factor) is a Protein Coding gene. Diseases associated with MYDGF include major depressive disorder and accelerated response to antidepressant drug treatment and myocardial infarction. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR).

UniProtKB/Swiss-Prot for MYDGF Gene

  • Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYDGF Gene

Genomics for MYDGF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYDGF Gene

Chromosome:
19
Start:
4,641,374 bp from pter
End:
4,670,403 bp from pter
Size:
29,030 bases
Orientation:
Minus strand

Genomic View for MYDGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYDGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYDGF Gene

No data available for Regulatory Elements for MYDGF Gene

Proteins for MYDGF Gene

  • Protein details for MYDGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H8-MYDGF_HUMAN
    Recommended name:
    Myeloid-derived growth factor
    Protein Accession:
    Q969H8
    Secondary Accessions:
    • D6W628
    • O75256
    • O75272
    • Q9BTK7
    • Q9NP69

    Protein attributes for MYDGF Gene

    Size:
    173 amino acids
    Molecular mass:
    18795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MYDGF Gene

Proteomics data for MYDGF Gene at MOPED

Post-translational modifications for MYDGF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYDGF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYDGF Gene

Domains & Families for MYDGF Gene

Protein Domains for MYDGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYDGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969H8

UniProtKB/Swiss-Prot:

MYDGF_HUMAN :
  • Belongs to the MYDGF family.
Family:
  • Belongs to the MYDGF family.
genes like me logo Genes that share domains with MYDGF: view

No data available for Gene Families for MYDGF Gene

Function for MYDGF Gene

Molecular function for MYDGF Gene

UniProtKB/Swiss-Prot Function:
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to myocardial infarction (MI).

Gene Ontology (GO) - Molecular Function for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MYDGF: view

Phenotypes for MYDGF Gene

GenomeRNAi human phenotypes for MYDGF:
genes like me logo Genes that share phenotypes with MYDGF: view

miRNA for MYDGF Gene

miRTarBase miRNAs that target MYDGF

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYDGF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYDGF Gene

Localization for MYDGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYDGF Gene

Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Note=Secreted into blood plasma. {ECO:0000269 PubMed:25581518}.

Gene Ontology (GO) - Cellular Components for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 25581518
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYDGF: view

No data available for Subcellular locations from COMPARTMENTS for MYDGF Gene

Pathways & Interactions for MYDGF Gene

genes like me logo Genes that share pathways with MYDGF: view

Pathways by source for MYDGF Gene

Gene Ontology (GO) - Biological Process for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001938 positive regulation of endothelial cell proliferation IDA 25581518
GO:0006915 apoptotic process IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for SIGNOR curated interactions for MYDGF Gene

Drugs & Compounds for MYDGF Gene

(1) Drugs for MYDGF Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(2) Additional Compounds for MYDGF Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
RANTES
SDF 1
genes like me logo Genes that share compounds with MYDGF: view

Transcripts for MYDGF Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYDGF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYDGF Gene

No ASD Table

Relevant External Links for MYDGF Gene

GeneLoc Exon Structure for
MYDGF
ECgene alternative splicing isoforms for
MYDGF

Expression for MYDGF Gene

mRNA expression in normal human tissues for MYDGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYDGF Gene

This gene is overexpressed in Oral epithelium (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYDGF Gene



mRNA Expression by UniProt/SwissProt for MYDGF Gene

Q969H8-MYDGF_HUMAN
Tissue specificity: Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
genes like me logo Genes that share expression patterns with MYDGF: view

Protein tissue co-expression partners for MYDGF Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MYDGF Gene

Orthologs for MYDGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYDGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7H19orf10 35
  • 88.44 (n)
  • 89.02 (a)
C7H19orf10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf10 35
  • 89.21 (n)
  • 90.17 (a)
C19orf10 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu104e 35
  • 84.04 (n)
  • 87.88 (a)
D17Wsu104e 16
D17Wsu104e 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf10 35
  • 90.75 (n)
  • 89.02 (a)
C19ORF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC501282 35
  • 80 (n)
  • 80.61 (a)
oppossum
(Monodelphis domestica)
Mammalia C19orf10 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf10 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF10 35
  • 68.57 (n)
  • 66.43 (a)
C28H19ORF10 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf10 35
  • 61.43 (n)
  • 57.86 (a)
Str.16428 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16799 35
zebrafish
(Danio rerio)
Actinopterygii zgc:92871 35
  • 61.44 (n)
  • 59.7 (a)
C22H19orf10 (1 of 2) 36
  • 53 (a)
OneToMany
C22H19orf10 (2 of 2) 36
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10031 35
Species with no ortholog for MYDGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYDGF Gene

ENSEMBL:
Gene Tree for MYDGF (if available)
TreeFam:
Gene Tree for MYDGF (if available)

Paralogs for MYDGF Gene

No data available for Paralogs for MYDGF Gene

Variants for MYDGF Gene

Sequence variations from dbSNP and Humsavar for MYDGF Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11148 -- 4,657,945(-) CTGTG(G/T)CCCTG utr-variant-3-prime
rs12683 -- 4,658,035(-) GTGAT(A/C/T)GTGGC synonymous-codon, reference
rs758325 -- 4,659,652(+) CCACC(A/G)CGCCC intron-variant
rs1127798 -- 4,670,293(-) GCGAC(G/T)TTGTG frameshift-variant
rs2074966 -- 4,670,494(+) CTTTG(C/T)CGAGG upstream-variant-2KB

Variation tolerance for MYDGF Gene

Residual Variation Intolerance Score: 63.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYDGF Gene

HapMap Linkage Disequilibrium report
MYDGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYDGF Gene

Disorders for MYDGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYDGF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
myocardial infarction
  • myocardial infarction, protection against
- elite association
Search MYDGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYDGF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYDGF
genes like me logo Genes that share disorders with MYDGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYDGF Gene

Publications for MYDGF Gene

  1. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. (PMID: 25581518) Korf-Klingebiel M. … Wollert K.C. (Nat. Med. 2015) 2 67
  2. Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. (PMID: 21128247) Sunagozaka H. … Kaneko S. (Int. J. Cancer 2011) 2 67
  3. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. (PMID: 20018810) Carretero-Ortega J. … VA!zquez-Prado J. (Mol. Pharmacol. 2010) 23 67
  4. IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma. (PMID: 19906013) Smith D.E. (Clin. Exp. Allergy 2010) 23 67
  5. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. (PMID: 19968632) Xu G. … Li H.B. (Allergy 2010) 23 67

Products for MYDGF Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MYDGF
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MYDGF
    • Block miRNA regulation of MYDGF using miScript Target Protectors

    Sources for MYDGF Gene

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