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MYD88 Gene

protein-coding   GIFtS: 67
GCID: GC03P038179

Myeloid Differentiation Primary Response 88

(Previous name: myeloid differentiation primary response gene (88))
  See MYD88-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Myeloid Differentiation Primary Response 881 2
Myeloid Differentiation Primary Response Gene (88)1 2
MYD88D2 5
Myeloid Differentiation Primary Response Protein MyD882

External Ids:    HGNC: 75621   Entrez Gene: 46152   Ensembl: ENSG000001729367   OMIM: 6021705   UniProtKB: Q998363   
ORGUL members:         

Export aliases for MYD88 gene to outside databases

Previous GC identifers: GC03P037467 GC03M038006 GC03P037993 GC03P038140 GC03P038155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYD88 Gene:
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune
response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor
signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded
protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with
defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Feb 2010)

GeneCards Summary for MYD88 Gene:
MYD88 (myeloid differentiation primary response 88) is a protein-coding gene. Diseases associated with MYD88 include pyogenic bacterial infections due to myd88 deficiency, and macroglobulinemia, waldenstrom, somatic. GO annotations related to this gene include identical protein binding and TIR domain binding.

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate
immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and
the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates
IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS,
and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut
homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine

Gene Wiki entry for MYD88 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYD88 gene promoter:
         c-Fos   AP-1   ATF-2   STAT3   c-Jun   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYD88 promoter sequence
   Search Chromatin IP Primers for MYD88

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYD88


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22

MYD88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYD88 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038179:  view genomic region     (about GC identifiers)

Start:
38,179,969 bp from pter      End:
38,184,513 bp from pter
Size:
4,545 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836 (See protein sequence)
Recommended Name: Myeloid differentiation primary response protein MyD88  
Size: 296 amino acids; 33233 Da
Subunit: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their
respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1
and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist.
Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B
treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2
to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence
negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with
PIK3AP1
Sequence caution: Sequence=BAG60822.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAG60834.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=EAW64521.1;
Type=Erroneous gene model prediction;
5 PDB 3D structures from and Proteopedia for MYD88:
2JS7 (3D)        2Z5V (3D)        3MOP (3D)        4DOM (3D)        4EO7 (3D)    
Secondary accessions: B4DKH8 B4DKU4 B4DQ60 B4DQ72 J3KPU4 J3KQ87 J3KQJ6 P78397 Q53XS7
Alternative splicing: 6 isoforms:  Q99836-1   Q99836-2   Q99836-3   Q99836-4   Q99836-5   Q99836-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYD88: NX_Q99836

Explore proteomics data for MYD88 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys95, Lys119, Lys231, Lys282
  • Modification sites at PhosphoSitePlus

  • See MYD88 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001166037.1  NP_001166038.1  NP_001166039.1  NP_001166040.1  NP_002459.2  

    ENSEMBL proteins: 
     ENSP00000379625   ENSP00000389979   ENSP00000417848   ENSP00000390565   ENSP00000391753  
     ENSP00000401399  
    Reactome Protein details: Q99836

    MYD88 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

     
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for MYD88 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR000157 TIR_dom
     IPR000488 Death_domain
     IPR017281 Myelin_different_resp_MyD88

    Graphical View of Domain Structure for InterPro Entry Q99836

    ProtoNet protein and cluster: Q99836

    UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836
    Domain: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK (By similarity)
    Similarity: Contains 1 death domain
    Similarity: Contains 1 TIR domain


    Find genes that share domains with MYD88           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYD88_HUMAN, Q99836
    Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate
    immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and
    the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates
    IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS,
    and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut
    homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine

         Genatlas biochemistry entry for MYD88:
    myeloid differentiation primary response gene,88,binding the cytoplasmic tail of TLR proteins leading to their
    activation,initiating an intracellular signaling pathway to NFKB and its target genes

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005121Toll binding ----
    GO:0005123death receptor binding TAS9374458
    GO:0005149interleukin-1 receptor binding ----
    GO:0005515protein binding IPI10880445
         
    Find genes that share ontologies with MYD88           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Myd88) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with MYD88           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYD88: Myd88tm1Aki Myd88tm1.1Papr Myd88tm1.1Defr Myd88tm1Hlz

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYD88
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYD88
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYD88

    miRNA
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    miRTarBase miRNAs that target MYD88:
    hsa-mir-155-5p (MIRT020533), hsa-mir-203a (MIRT007368)

    Block miRNA regulation of human, mouse, rat MYD88 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYD88 (see all 10):
    hsa-miR-4300 hsa-miR-650 hsa-miR-4267 hsa-miR-221* hsa-miR-920 hsa-miR-298 hsa-miR-1827 hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidMYD88 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYD88

    Gene Editing
    Products:
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    Clone
    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 5): MYD88 (NM_001172566)
    Sino Biological Human cDNA Clone for MYD88
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYD88
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYD88
    Addgene plasmids for MYD88 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYD88_HUMAN, Q99836: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    plasma membrane4
    nucleus3
    extracellular2
    vacuole2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0014069postsynaptic density ----
    GO:0043234protein complex ----

    Find genes that share ontologies with MYD88           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYD88 About   (see all 34)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    IL-1 Family Signaling Pathways0.44
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    2Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    IL1-mediated signaling events0.45
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    4Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    5Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL 1 beta dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47


    Find genes that share SuperPaths with MYD88           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for MYD88
        Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYD88 (see all 12)
        14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    NTHi-Induced Signaling

    2 Cell Signaling Technology (CST) Pathways for MYD88
        Lymphocyte Signaling
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MYD88 (see all 10)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression

    Selected BioSystems Pathways for MYD88 (see all 7)
        Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    AGE/RAGE pathway
    Toll-like receptor signaling pathway
    IL1-mediated signaling events


    Selected Reactome Pathways for MYD88 (see all 12)
        p75NTR recruits signalling complexes
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    TRAF6 mediated IRF7 activation
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    Selected Kegg Pathways  (Kegg details for MYD88) (see all 16):
        NF-kappa B signaling pathway
    Apoptosis
    Toll-like receptor signaling pathway
    Salmonella infection
    Pertussis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYD88 (see all 14): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYD88

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYD88 (Q998361, 2, 3 ENSP000003796254) via UniProtKB, MINT, STRING, and/or I2D (see all 172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIRAPP587531, 2, 3, ENSP000003764454EBI-447677,EBI-528644 MINT-4950432 MINT-4950481 I2D: score=6 STRING: ENSP00000376445
    FADDQ131581, 3, ENSP000003018384EBI-447677,EBI-494804 I2D: score=5 STRING: ENSP00000301838
    TNFRSF13BO148361, 3, ENSP000002616524EBI-447677,EBI-519160 I2D: score=2 STRING: ENSP00000261652
    STAP2Q9UGK31, 3EBI-447677,EBI-1553984 I2D: score=3 
    ENSG00000183311P074373I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002238response to molecule of fungal origin ----
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction NAS9013863

    Find genes that share ontologies with MYD88           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYD88

    Selected Novoseek inferred chemical compound relationships for MYD88 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoteichoic acid 69.3 4 20167866 (2), 18802114 (1), 12806620 (1)
    tab-2 69.1 2 18786322 (1), 18353240 (1)
    flagellin 63.2 10 19619129 (4), 16644730 (3), 19573161 (1), 19806220 (1) (see all 5)
    peptidoglycan 57.4 5 11254583 (3), 17182109 (1), 14660668 (1)
    endotoxin 45.2 3 12032143 (2), 17569868 (1)
    rantes 43.5 3 14517278 (1), 15557184 (1)
    monosodium urate 32 2 15814732 (1), 16886051 (1)
    phosphatidylinositol 29.9 5 12865424 (1), 17055754 (1), 16644730 (1), 16738560 (1) (see all 5)
    tyrosine 20.8 5 18070880 (2), 18292575 (2), 16477040 (1)
    ly294002 17.3 1 20167866 (1)



    Find genes that share compounds with MYD88           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYD88 gene (5 alternative transcripts): 
    NM_001172566.1  NM_001172567.1  NM_001172568.1  NM_001172569.1  NM_002468.4  

    Unigene Cluster for MYD88:

    Myeloid differentiation primary response 88
    Hs.82116  [show with all ESTs]
    Unigene Representative Sequence: NM_001172567
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396334(uc011ayi.2 uc011ayj.2 uc011ayk.2 uc011ayl.2)
    ENST00000424893 ENST00000416282 ENST00000460295(uc011ayh.2) ENST00000495303
    ENST00000443433 ENST00000421516 ENST00000481122 ENST00000484513 ENST00000463956
    ENST00000417037(uc003chx.3)
    miRNA
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    hsa-miR-4300 hsa-miR-650 hsa-miR-4267 hsa-miR-221* hsa-miR-920 hsa-miR-298 hsa-miR-1827 hsa-miR-1286
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    GenScript: all cDNA clones in your preferred vector (see all 5): MYD88 (NM_001172566)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYD88
    Addgene plasmids for MYD88 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MYD88
      QuantiFast Probe-based Assays in human, mouse, rat MYD88

    Additional mRNA sequence: 

    AB446470.1 AK097983.1 AK296570.1 AK296716.1 AK298650.1 AK298666.1 AK300448.1 AK304676.1 
    AL832906.1 BC013589.1 BT007376.1 BX537602.1 U70451.1 U84408.1 

    21 DOTS entries:

    DT.91748529  DT.120880241  DT.117375  DT.100796020  DT.95185409  DT.95375872  DT.95284868  DT.100796010 
    DT.100796015  DT.120880216  DT.97798804  DT.120880240  DT.97812950  DT.100796014  DT.120880246  DT.95375870 
    DT.100691713  DT.120880238  DT.95319978  DT.100796018  DT.91699872 

    Selected AceView cDNA sequences (see all 260):

    CB159594 AA554584 AL554284 AL603271 BE782224 CD251949 AI347663 BF795078 
    AA632047 BP362471 W56725 BU952448 BP373604 CR619528 BU507645 AI969807 
    BP365241 BU624964 NM_002468 BG249160 BU150272 BM832892 BP359790 AL557704 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYD88 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                    -           -                 -                                       
    SP2:                    -           -                                                         
    SP3:                    -           -           -     -                                       
    SP4:                    -     -     -                                                         
    SP5:                    -     -     -     -     -     -                                       


    ECgene alternative splicing isoforms for MYD88

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MYD88 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTACGC
    MYD88 Expression
    About this image


    MYD88 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    MYD88 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYD88 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82116

    UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYD88 (see all 14): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYD88

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MYD88 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myd881 , 5 myeloid differentiation primary response gene 881, 5 82.37(n)1
    84.53(a)1
      9 (71.33 cM)5
    178741  NM_010851.21  NP_034981.11 
     1193359345 
    chicken
    (Gallus gallus)
    Aves MYD881 myeloid differentiation primary response gene (88) 71.45(n)
    71.69(a)
      420420  NM_001030962.1  NP_001026133.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYD886
    myeloid differentiation primary response 88
    63(a)
    1 ↔ 1
    6(882558-890643)
    African clawed frog
    (Xenopus laevis)
    Amphibia myd88-A2 Toll/IL-1 receptor binding protein MyD88 76.32(n)    AF294272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myd881 myeloid differentiation primary response gene (88) 63.02(n)
    64.23(a)
      403145  NM_212814.2  NP_997979.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myd886
    Myd88
    15(a)
    1 ↔ 1
    2R(5190328-5196227)


    ENSEMBL Gene Tree for MYD88 (if available)
    TreeFam Gene Tree for MYD88 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MYD88 (see all 105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0479534
    MYD88 deficiency (MYD88D)4--see VAR_0479532 L P mis40--------
    VAR_0479544
    MYD88 deficiency (MYD88D)4--see VAR_0479542 R C mis40--------
    rs562718031,2
    C--38115971(+) ATACAC/GACACA 5 -- ut310--------
    rs1456085501,2
    --38116011(+) ACACAA/CAGGCA 5 -- ut310--------
    rs1821102101,2
    --38116077(+) TCCCAA/TCACTG 5 -- ut310--------
    rs761805561,2
    C,F--38116085(+) CTGAGG/AGAGCC 5 -- ut311Minor allele frequency- A:0.02WA 118
    rs1880435761,2
    C--38116150(+) CCCTAC/TTCATT 5 -- ut310--------
    rs1930894161,2
    --38116163(+) AACCAA/TACTCT 5 -- ut310--------
    rs1853886211,2
    --38116197(+) TTTATA/GCCTCT 5 -- ut310--------
    rs77441,2
    C,F,A,H--38116204(+) CTCTAA/GTGAAG 5 -- ut3143Minor allele frequency- G:0.15MN EA NA NS CSA WA 3990

    HapMap Linkage Disequilibrium report for MYD88 (38179969 - 38184513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYD88: --
    Human Gene Mutation Database (HGMD): MYD88
    Selected Site Specific Mutation Identification with PCR Assays for MYD88 (see all 7):
    Cosmic IdAA Change
    85947p.I220T
    85957p.S222R
    85942p.M232T
    85941p.V217F
    85944p.S219C
    SeqTarget long-range PCR primers for resequencing MYD88
    DNA2.0 Custom Variant and Variant Library Synthesis for MYD88

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602170   
    OMIM disorders: 612260  153600  
    UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836
  • MYD88 deficiency (MYD88D) [MIM:612260]: Patients suffer from autosomal recessive, life-threatening, often
    recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months
    of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical
    status improved with age. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for MYD88:    
    About MalaCards
    pyogenic bacterial infections due to myd88 deficiency    macroglobulinemia, waldenstrom, somatic    macroglobulinemia    blastic plasmacytoid dendritic cell
    primary cutaneous diffuse large b-cell lymphoma, leg type    lymphoplasmacytic lymphoma    lymphocytic choriomeningitis    diffuse large b-cell lymphoma
    kawasaki disease

    1 disease from the University of Copenhagen DISEASES database for MYD88:
    Pneumonia

    Find genes that share disorders with MYD88           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MYD88 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 50.2 28 12297423 (1), 9575168 (1), 14769151 (1), 15324355 (1) (see all 25)
    inflammation 47.8 8 19948979 (1), 9374458 (1), 19085995 (1), 17121361 (1) (see all 7)
    bacterial infections 33.1 1 18986247 (1)
    anaplasmosis 30.3 1 15214026 (1)
    tumors 28.9 33 12297423 (1), 9575168 (1), 14769151 (1), 15324355 (1) (see all 29)
    sepsis 22.7 16 16518342 (3), 18786322 (1), 18086373 (1), 19181857 (1)
    shock septic 16.9 2 19181857 (1)
    virus infection 16.6 3 15724245 (1), 18948575 (1)
    kawasaki disease 16.4 1 16275884 (1)
    autoimmune diseases 16.4 2 19006693 (1), 19898473 (1)

    Genetic Association Database (GAD): MYD88
    Human Genome Epidemiology (HuGE) Navigator: MYD88 (31 documents)

    Export disorders for MYD88 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYD88 gene, integrated from 10 sources (see all 576):
    (articles sorted by number of sources associating them with MYD88)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. (PubMed id 9013863)1, 2, 3 Bonnert T.P.... Sims J.E. (FEBS Lett. 1997)
    2. Molecular characterization and modular analysis of human MyD88. (PubMed id 8957090)1, 2, 9 Hardiman G....Bazan J.F. (Oncogene 1996)
    3. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N.... Sibilia J. (J. Immunol. 2008)
    4. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PubMed id 15361868)1, 2, 9 Kawai T.... Akira S. (Nat. Immunol. 2004)
    5. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (PubMed id 19506249)1, 2, 9 Ohnishi H.... Shirakawa M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. (PubMed id 19265123)1, 2, 9 Dai P.... Chen X. (J. Immunol. 2009)
    7. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. (PubMed id 19254290)1, 4, 9 Tewfik M.A....Desrosiers M. (Allergy 2009)
    8. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2, 9 Nakajima T....Kimura A. (Immunogenetics 2008)
    9. IKKI/-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. (PubMed id 23453969)1, 2 Zhou A.Y....Hahn W.C. (Cell Rep 2013)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4615 HGNC: 7562 AceView: MYD88 Ensembl:ENSG00000172936 euGenes: HUgn4615
    ECgene: MYD88 Kegg: 4615 H-InvDB: MYD88

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYD88 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYD88 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYD88 gene:
    Search GeneIP for patents involving MYD88

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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