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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYD88 Gene

protein-coding GIFtS: 62
GCID: GC03P038179

myeloid differentiation primary response 88

(Previous name: myeloid differentiation primary response gene (88) )

Explore 62 diseases affiliated with
MYD88 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myeloid Differentiation Primary Response 88¹ ²
Myeloid Differentiation Primary Response Gene (88)¹ ²
MYD88D² ⁵
Myeloid Differentiation Primary Response Protein MyD88²

External Ids:	HGNC: 7562¹	Entrez Gene: 4615²	Ensembl: ENSG00000172936⁷	OMIM: 602170⁵	UniProtKB: Q99836³

Export aliases for MYD88 gene to outside databases

Previous GC identifers: GC03P037467 GC03M038006 GC03P037993 GC03P038140 GC03P038155

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYD88:

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.

This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling

pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of

an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have

an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript

variants. (provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836

Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune

response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the

inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1

resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A

genes (By similarity)

Gene Wiki entry for MYD88

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYD88 gene promoter:
c-Fos AP-1 ATF-2 STAT3 c-Jun IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYD88 promoter sequence

Search SABiosciences Chromatin IP Primers for MYD88

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYD88

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22

MYD88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYD88 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P038179: view genomic region (about GC identifiers)

Start:	38,179,969 bp from pter	End:	38,184,513 bp from pter
Size:	4,545 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836 (See protein sequence)

Recommended Name: Myeloid differentiation primary response protein MyD88

Size: 296 amino acids; 33233 Da

Subunit: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their

respective TIR domains. Interacts with IL18R1 (By similarity). Interacts with BMX, IL1RL1 and IRF7. Interacts with

LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist.

Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1 (By similarity).

Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and

TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence

negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression

Subcellular location: Cytoplasm

3 PDB 3D structures from and Proteopedia for MYD88:

2JS7 (3D)

2Z5V (3D)

3MOP (3D)

Secondary accessions: B4DKH8 B4DQ60 B4DQ72 P78397 Q53XS7

Alternative splicing: 4 isoforms: Q99836-1 Q99836-2 Q99836-3 Q99836-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYD88: NX_Q99836

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99836

MYD88 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001166037.1 NP_001166038.1 NP_001166039.1 NP_001166040.1 NP_002459.2

ENSEMBL proteins:

ENSP00000379625 ENSP00000389979 ENSP00000417848 ENSP00000390565 ENSP00000391753

ENSP00000401399

Reactome Protein details: Q99836
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MYD88 OriGene Protein Over-expression Lysate (see all 2): MYD88 OriGene Custom Protein Services for MYD88
	GenScript Custom Purified and Recombinant Proteins Services for MYD88
	Novus Biologicals MYD88 Proteins Novus Biologicals MYD88 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0010008	endosome membrane	TAS	--

MYD88 for ontologies About GeneDecksing

MYD88 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MYD88
	R&D Systems Antibodies for MYD88
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	GenScript Custom Superior Antibodies Services for MYD88
	Novus Biologicals MYD88 Antibodies
	Abcam antibodies for MYD88
	Browse Antibodies at Uscn
	ThermoFisher Antibody for MYD88

Assay Products for MYD88:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MYD88
	GenScript Custom Assay Services for MYD88
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYD88 for domains About GeneDecksing

4 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR000157 TIR_dom

IPR000488 Death_domain

IPR017281 Myelin_different_resp_MyD88

Graphical View of Domain Structure for InterPro Entry Q99836

ProtoNet protein and cluster: Q99836

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836

Domain: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK (By similarity)

Similarity: Contains 1 death domain

Similarity: Contains 1 TIR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836

Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune

response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the

inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1

resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A

genes (By similarity)

Genatlas biochemistry entry for MYD88:

myeloid differentiation primary response gene,88,binding the cytoplasmic tail of TLR proteins leading to their

activation,initiating an intracellular signaling pathway to NFKB and its target genes

miRNA Products:		OriGene 3'-UTR Clone: MYD88 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYD88
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MYD88 (see all 10):
		hsa-miR-4300 hsa-miR-650 hsa-miR-4267 hsa-miR-221* hsa-miR-920 hsa-miR-298 hsa-miR-1827 hsa-miR-1286

		SwitchGear 3'UTR luciferase reporter plasmid: MYD88 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYD88 (see all 7) OriGene shRNA RFP: MYD88 OriGene siRNA: MYD88
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYD88

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYD88

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYD88 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYD88 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): MYD88 (NM_001172566)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYD88

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYD88
		Search LifeMap BioReagents cell lines for MYD88

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYD88

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005121	Toll binding	--	--
GO:0005123	death receptor binding	TAS	9374458
GO:0005515	protein binding	IPI	--
GO:0042802	identical protein binding	IPI	--

MYD88 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for MYD88: Myd88^tm1Aki Myd88^tm1.1Papr Myd88^tm1.1Defr Myd88^tm1Hlz
     15/20 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Myd88) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	nervous system	no phenotypic analysis	renal/urinary system

MYD88 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/14 pathways (see all 14)
Toll Like Receptor 10 (TLR10) Cascade	0.86	Toll Like Receptor TLR6:TLR2 Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MyD88 cascade initiated on plasma membrane	0.86	Toll Like Receptor 2 (TLR2) Cascade	0.78
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.85	MyD88:Mal cascade initiated on plasma membrane	0.78

Toll Comparative Pathway

Toll Comparative Pathway	1.00	Immune response MIF in innate immunity response	0.46
TLR-TRIF Pathway	0.61	IL-1 Pathway	0.39
Immune response_MIF in innate immunity response	0.46	iNOS Signaling	0.34

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway	1.00	Chagas disease (American trypanosomiasis)	0.31
Toll-like receptor signaling pathway	0.97	Inflammasome Activation Pathways	0.29
Toll-Like receptor Signaling Pathways	0.51

Immune response_Bacterial infections in normal airways

	Immune response_Bacterial infections in normal airways	1.00			IL-1 beta-dependent CFTR expression	0.43
	Bacterial infections in CF airways	0.78

Mucin expression in CF via IL-6, IL-17 signaling pathways

	Cytokine production by Th17 cells in CF	0.45			Cytokine production by Th17 cells in CF (Mouse model)	0.37
	Mucin expression in CF via TLRs, EGFR signaling pathways	0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for MYD88

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response MIF in innate immunity response
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways
	Immune response IL-1 signaling pathway

2 R&D Systems Pathways for MYD88

	Inflammasome Activation Pathways
	Toll-Like receptor Signaling Pathways

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYD88 (see all 12)

	14-3-3 Induced Apoptosis
	NF-KappaB (p50-p65) Pathway
	Toll-Like Receptors Pathway
	TRAF Pathway
	NTHi-Induced Signaling

2 Cell Signaling Technology (CST) Pathways for MYD88

	Lymphocyte Signaling
	NF-kappaB Signaling

5/10 GeneGo (Thomson Reuters) Pathways for MYD88 (see all 10)

	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Immune response TLR signaling pathways
	Bacterial infections in CF airways
	IL-1 beta-dependent CFTR expression

5/6 BioSystems Pathways for MYD88 (see all 6)

	AGE/RAGE pathway
	Apoptosis Modulation and Signaling
	IL-1 Signaling Pathway
	Toll-like receptor signaling pathway
	IL1-mediated signaling events

5/26 Reactome Pathways for MYD88 (see all 26)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	Toll-Like Receptors Cascades
	p75 NTR receptor-mediated signalling

5/11 Kegg Pathways (Kegg details for MYD88) (see all 11):

	Apoptosis
	Toll-like receptor signaling pathway
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)

MYD88 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MYD88

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/125 Interacting proteins for MYD88 (Q99836^{1, 2, 3} ENSP00000379625⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 125)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIRAP	P58753¹^,²^,³, ENSP00000376445⁴	EBI-447677,EBI-528644 MINT-4950432 MINT-4950481 I2D: score=6 STRING: ENSP00000376445
IRAK1	P51617²^,³, ENSP00000358997⁴	MINT-50481 I2D: score=9 STRING: ENSP00000358997
IRAK3	Q9Y616²^,³, ENSP00000261233⁴	MINT-50483 I2D: score=6 STRING: ENSP00000261233
IRAK2	O43187²^,³, ENSP00000256458⁴	MINT-50482 I2D: score=5 STRING: ENSP00000256458
STAP2	Q9UGK3¹^,³, ENSP00000317912⁴	EBI-447677,EBI-1553984 I2D: score=3 STRING: ENSP00000317912

About this table

Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002238	response to molecule of fungal origin	--	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	NAS	9013863

MYD88 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYD88 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYD88
10/21 Novoseek chemical compound relationships for MYD88 gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipoteichoic acid	69.3	4	20167866 (2), 18802114 (1), 12806620 (1)
tab-2	69.1	2	18786322 (1), 18353240 (1)
flagellin	63.2	10	19619129 (4), 16644730 (3), 19573161 (1), 19806220 (1) (see all 5)
peptidoglycan	57.4	5	11254583 (3), 17182109 (1), 14660668 (1)
endotoxin	45.2	3	12032143 (2), 17569868 (1)
rantes	43.5	3	14517278 (1), 15557184 (1)
monosodium urate	32	2	15814732 (1), 16886051 (1)
phosphatidylinositol	29.9	5	12865424 (1), 17055754 (1), 16644730 (1), 16738560 (1) (see all 5)
tyrosine	20.8	5	18070880 (2), 18292575 (2), 16477040 (1)
ly294002	17.3	1	20167866 (1)

Search CenterWatch for drugs/clinical trials and news about MYD88

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYD88 gene (5 alternative transcripts):

NM_001172566.1 NM_001172567.1 NM_001172568.1 NM_001172569.1 NM_002468.4

Unigene Cluster for MYD88:

Myeloid differentiation primary response 88

Hs.82116 [show with all ESTs]

Unigene Representative Sequence: NM_001172567

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396334(uc011ayi.2 uc011ayj.2 uc011ayk.2 uc011ayl.2)

ENST00000424893 ENST00000416282 ENST00000460295(uc011ayh.2) ENST00000495303

ENST00000443433 ENST00000421516 ENST00000481122 ENST00000484513 ENST00000463956

ENST00000417037(uc003chx.3)

miRNA Products:		OriGene 3'-UTR Clone: MYD88 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYD88
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MYD88 (see all 10):
		hsa-miR-4300 hsa-miR-650 hsa-miR-4267 hsa-miR-221* hsa-miR-920 hsa-miR-298 hsa-miR-1827 hsa-miR-1286

		SwitchGear 3'UTR luciferase reporter plasmid: MYD88 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYD88 (see all 7) OriGene shRNA RFP: MYD88 OriGene siRNA: MYD88
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYD88

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYD88 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYD88 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): MYD88 (NM_001172566)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYD88
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYD88

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYD88 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MYD88
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYD88
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYD88

Additional cDNA sequence:

AB446470.1 AK097983.1 AK296570.1 AK296716.1 AK298650.1 AK298666.1 AK300448.1 AK304676.1

AL832906.1 BC013589.1 BT007376.1 BX537602.1 U70451.1 U84408.1

21 DOTS entries:

DT.91748529 DT.120880241 DT.117375 DT.100796020 DT.95185409 DT.95375872 DT.95284868 DT.100796010

DT.100796015 DT.120880216 DT.97798804 DT.120880240 DT.97812950 DT.100796014 DT.120880246 DT.95375870

DT.100691713 DT.120880238 DT.95319978 DT.100796018 DT.91699872

24/260 AceView cDNA sequences (see all 260):

BM800521 BP364091 BE859015 CD514044 BU952448 AI524571 BP359790 W56725

BP365241 AL558120 CD251949 AA134557 NM_002468 CB528472 AI969807 AA088632

AA946694 AA603087 AL554284 AK097983 BM828479 AA632047 CA447717 AU132830

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MYD88 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c
SP1:							-				-						-
SP2:							-				-
SP3:							-				-				-		-
SP4:							-		-		-
SP5:							-		-		-		-		-		-

ECgene alternative splicing isoforms for MYD88

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYD88 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTACGC

About this image
See MYD88 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYD88

SOURCE GeneReport for Unigene cluster: Hs.82116

UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including MYD88 (see all 14):

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

Inflammasomes in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MYD88 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myd88^{1 , 5}	myeloid differentiation primary response gene 88^{1, 5}	81.64(n)¹ 81.76(a)¹		9 (71.33 cM)⁵ 17874¹ NM_010851.2¹ NP_034981.1¹ 119335934⁵
chicken (Gallus gallus)	Aves	MYD88¹	myeloid differentiation primary response gene (88)	69.89(n) 69.66(a)		420420 NM_001030962.1 NP_001026133.1
lizard (Anolis carolinensis)	Reptilia	MYD88⁶	--	63(a)	1 ↔ 1	6(882558-890643)
African clawed frog (Xenopus laevis)	Amphibia	myd88-A²	Toll/IL-1 receptor binding protein MyD88	76.32(n)		AF294272.1
zebrafish (Danio rerio)	Actinopterygii	myd88¹	myeloid differentiation primary response gene (88)	63.02(n) 64.23(a)		403145 NM_212814.2 NP_997979.2
fruit fly (Drosophila melanogaster)	Insecta	Myd88⁶	Myd88	14(a)	1 ↔ 1	2R(5190328-5196227)

ENSEMBL Gene Tree for MYD88 (if available)
TreeFam Gene Tree for MYD88 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190018617^1,2		--	38180796(+)	`CTGTGA/GGGGCA`	5	--	int¹		0	--	--	--	--
rs181192113^1,2		--	38180803(+)	`GGCATC/GTGGGC`	5	--	int¹		0	--	--	--	--
rs75274680^1,2	C,F,	--	38181219(+)	`AGCTTC/TGCGTG`	5	--	int¹		1		EA	120
rs4988456^1,2	C,F,H,	--	38181230(+)	`GCACCA/GGTGAA`	5	--	int¹		11		NA EU NS	1214
rs185205720^1,2		--	38181295(+)	`CCTGAC/TTGTGG`	5	--	int¹		0	--	--	--	--
rs202195913^1,2		--	38181336(+)	`CTTTAC/TTCTGT`	5	--	int¹		0	--	--	--	--
rs189773684^1,2	C,	--	38181420(+)	`AGGTGA/GCCGCT`	8	T A	mis¹ int¹		0	--	--	--	--
rs138357324^1,2		--	38181633(+)	`GAAATG/TGAGAT`	5	--	int¹		0	--	--	--	--
rs180735209^1,2		--	38181667(+)	`GTGAGA/GTGCTC`	5	--	int¹		0	--	--	--	--
rs186265242^1,2	C,	--	38181914(+)	`TCTGCC/TATTGC`	8	H Y	mis¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MYD88 (38179969 - 38184513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYD88: --
Human Gene Mutation Database (HGMD): MYD88

5/7 SABiosciences Cancer Mutation PCR Assays for MYD88 (see all 7):

Cosmic Id	AA Change
85947	p.I220T
85957	p.S222R
85942	p.M232T
85941	p.V217F
85944	p.S219C

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYD88 for disorders           About GeneDecksing

OMIM gene information: 602170
OMIM disorders: 612260
UniProtKB/Swiss-Prot: MYD88_HUMAN, Q99836

Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic

bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often

recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of

age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status

improved with age

20/62 diseases for MYD88 (see all 62): About MalaCards

dengue hemorrhagic fever hemorrhagic fever otitis media lymphocytic choriomeningitis

systemic lupus erythematosus kawasaki disease tularemia gastrointestinal system disease

lupus erythematosus coronary heart disease inflammatory bowel disease chronic lymphocytic leukemia

dilated cardiomyopathy paracoccidioidomycosis herpes simplex epithelial ovarian cancer

lymphocytic leukemia hepatitis b squamous cell carcinoma cerebral infarction

2 diseases from the University of Copenhagen DISEASES database for MYD88:

Pneumonia Malaria

10/17 Novoseek disease relationships for MYD88 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	50.2	28	12297423 (1), 9575168 (1), 14769151 (1), 15324355 (1) (see all 25)
inflammation	47.8	8	19948979 (1), 9374458 (1), 19085995 (1), 17121361 (1) (see all 7)
bacterial infections	33.1	1	18986247 (1)
anaplasmosis	30.3	1	15214026 (1)
tumors	28.9	33	12297423 (1), 9575168 (1), 14769151 (1), 15324355 (1) (see all 29)
sepsis	22.7	16	16518342 (3), 18786322 (1), 18086373 (1), 19181857 (1)
shock septic	16.9	2	19181857 (1)
virus infection	16.6	3	15724245 (1), 18948575 (1)
kawasaki disease	16.4	1	16275884 (1)
autoimmune diseases	16.4	2	19006693 (1), 19898473 (1)

Human Genome Epidemiology (HuGE) Navigator: MYD88 (31 documents)

Export disorders for MYD88 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYD88 gene, integrated from 9 sources (see all 541):
(articles sorted by number of sources associating them with MYD88)

Utopia: connect your pdf to the dynamic
world of online information

The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. (PubMed id 9013863)^{1, 2, 3} Bonnert T.P.... Sims J.E. (1997)
Molecular characterization and modular analysis of human MyD88. (PubMed id 8957090)^{1, 2, 9} Hardiman G....Bazan J.F. (1996)
Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)^{1, 2, 9} Semaan N....Sibilia J. (2008)
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PubMed id 15361868)^{1, 2, 9} Kawai T....Akira S. (2004)
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (PubMed id 19506249)^{1, 2, 9} Ohnishi H.... Shirakawa M. (2009)
Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. (PubMed id 19265123)^{1, 2, 9} Dai P....Chen X. (2009)
Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)^{1, 2, 9} Nakajima T....Kimura A. (2008)
Pyogenic bacterial infections in humans with MyD88 deficiency. (PubMed id 18669862)^{1, 2} von Bernuth H.... Casanova J.-L. (2008)
Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. (PubMed id 16951688)^{1, 2} Choi K.C....Park S.H. (2006)
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)^{1, 2} Schmitz J....Kastelein R.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4615	HGNC: 7562	AceView: MYD88	Ensembl:ENSG00000172936	euGenes: HUgn4615
ECgene: MYD88	Kegg: 4615	H-InvDB: MYD88

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYD88	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MYD88	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MYD88 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYD88 gene:
Search GeneIP for patents involving MYD88

GeneCards and IP:
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MYD88 Gene

myeloid differentiation primary response 88

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MYD88 Gene

myeloid differentiation primary response 88

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