MYCT1 Gene
protein-coding GIFtS : 46
GCID: GC06 P153019
myc target 1
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Aliasesfor MYCT1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Myc Target 1 1 2 Myc Target In Myeloid Cells 12 MTLC1 2 3 Myc Target Protein 12 Myc Target In Myeloid Cells Protein 12 3 MTMC13 FLJ212691
Export aliases for MYCT1 gene to outside databases Previous GC identifers: GC06P153050 GC06P153111 GC06P153061 GC06P153062 GC06P150582
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Summariesfor MYCT1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MYCT1_HUMAN, Q8N699 Function : May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does notseem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)
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Genomic Viewsfor MYCT1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MYCT1 gene promoter: HOXA9B HOXA9 GR Evi-1 FAC1 S8 GR-alpha Meis-1a Hlf Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for MYCT1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCT1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q25.2 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q25.1 MYCT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P153019: view genomic region
(about GC identifiers )
Start:
153,019,030 bp from pter
End:
153,045,717 bp from pter
Size:
26,688 bases
Orientation:
plus strand
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Proteinsfor MYCT1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MYCT1_HUMAN, Q8N699 (See
protein sequence )Recommended Name: Myc target protein 1 Size : 235 amino acids; 26593 Da
Subcellular location : Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells
Caution : It is uncertain whether Met-1 or Met-49 is the initiator
Secondary accessions : Q8N396 Q8TBE8 Q9H763Explore the universe of human proteins at neXtProt for MYCT1: NX_Q8N699 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N699 MYCT1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_079383.2 ENSEMBL proteins: ENSP00000356214 ENSP00000432612 ENSP00000434396 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
MYCT1 for ontologies About GeneDecksing MYCT1 Antibody Products: Assay Products for MYCT1:
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Protein
Domains / Familiesfor MYCT1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q8N699
UniProtKB/Swiss-Prot: MYCT1_HUMAN, Q8N699 Similarity : Belongs to the MYCT1 family
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Functionfor MYCT1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MYCT1_HUMAN, Q8N699 Function : May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does notseem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MYCT1 (NM_025107 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYCT1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYCT1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCT1
1 GenomeRNAi human phenotype for MYCT1 :
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Pathways & Interactionsfor MYCT1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Validated targets of C-MYC transcriptional activation
1 BioSystems Pathway for MYCT1 Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYCT1 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for MYCT1 (ENSP00000356214 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor MYCT1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MYCT1 Search CenterWatch for drugs/clinical trials and news about MYCT1
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Transcriptsfor MYCT1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MYCT1 gene: NM_025107.2 Unigene Cluster for MYCT1:
Myc target 1 Hs.18160 [show with all ESTs ] Unigene Representative Sequence: NM_025107 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367245 (uc003qpc.4 ) ENST00000529453 ENST00000532295 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MYCT1 (NM_025107 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYCT1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYCT1
Additional cDNA sequence: AF527367.1 AK021612.1 AK024922.1 AL834500.1 BC022556.1 BC128463.1 BC128464.1 GU997693.1
3 DOTS entries : DT.309010 DT.121383311
DT.442176 24/50 AceView cDNA sequences (see all 50 ):
NM_025107 AA152372 BU150480 CR599312 AA001908 AF527367 AK024922 CA407788 BX475034 AU144790 AU118145 AU118319 AA677418 BC022556 AI565299 AI242583 AW291988 AK021612 AI056605 AL834500 BX348976 BU681316 AA122399 BG707617 GeneLoc Exon Structure
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Expression for MYCT1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MYCT1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAAATCAGC
About this image MYCT1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MYCT1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MYCT1 SOURCE GeneReport for Unigene cluster: Hs.18160 UniProtKB/Swiss-Prot: MYCT1_HUMAN, Q8N699 Tissue specificity : Down-regulated in gastric cancer tissues SABiosciences Custom PCR Arrays for MYCT1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MYCT1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MYCT1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYCT1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYCT1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCT1
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Orthologsfor MYCT1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MYCT1 gene from 4/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for MYCT1 (if available)TreeFam Gene Tree for MYCT1 (if available)
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Paralogsfor MYCT1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MYCT1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MYCT1 (153019030 - 153045717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for MYCT1 7 CNVs : 6519 39483 62589 39484 43546 99758 44235
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MYCT1
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Disorders
/ Diseasesfor MYCT1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MYCT1 for disorders About GeneDecksing 6 diseases for MYCT1 : About MalaCards mixed cell type cancer cell type cancer hepatocellular carcinoma laryngitis gastric cancer carcinoma 1 disease from the University of Copenhagen DISEASES database for MYCT1 :Laryngeal squamous cell carcinoma Human Genome Epidemiology (HuGE) Navigator: MYCT1 (1 document)Export disorders for MYCT1 gene to outside databases
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Publicationsfor MYCT1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MYCT1 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with MYCT1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Expression of MTLC gene in gastric carcinoma. (PubMed id 14562369) 1 , 2 Qiu G.-B.... Sun K.-L. (2003) Cloning and characterization of MTLC, a novel gene in 6q25. (PubMed id 12673574) 1 , 2 Qiu G.-B....Sun K.-L. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Promoter hypermethylation-induced transcriptional down -regulation of the gene MYCT1 in laryngeal squamous cell carcinoma. (PubMed id 22672838) 1 Yang M....Fu W.N. (2012) RUNX1-ETO deregulates the proliferation and growth fac tor responsiveness of human hematopoietic progenitor cells downstream of the mye loid transcription factor, MYCT1. (PubMed id 21799513) 1 Liddiard K....Tonks A. (2012) MYCT1-TV, A Novel MYCT1 Transcript, Is Regulated by c-Myc and May Participate in Laryngeal Carcinogenesis. (PubMed id 21998677) 1 Fu S....Fu W.N. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for MYCT1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MYCT1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MYCT1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MYCT1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MYCT1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MYCT1 gene: Search GeneIP for patents involving MYCT1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MYCT1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MYCT1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MYCT1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MYCT1 OriGene Protein Over-expression Lysate for MYCT1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MYCT1 OriGene 3'-UTR Clone for MYCT1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYCT1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MYCT1 OriGene Custom Protein Services for MYCT1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYCT1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MYCT1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCT1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MYCT1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYCT1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYCT1
Search Tocris compounds for MYCT1
MYCT1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCT1
ThermoFisher Antibodies for MYCT1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYCT1
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