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Aliases for MYCT1 Gene

Aliases for MYCT1 Gene

  • Myc Target 1 2 3
  • Myc Target In Myeloid Cells Protein 1 3 4
  • MTLC 3 4
  • Myc Target In Myeloid Cells 1 3
  • Myc Target Protein 1 3
  • MTMC1 4

External Ids for MYCT1 Gene

Summaries for MYCT1 Gene

GeneCards Summary for MYCT1 Gene

MYCT1 (Myc Target 1) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation.

UniProtKB/Swiss-Prot for MYCT1 Gene

  • May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCT1 Gene

Genomics for MYCT1 Gene

Genomic Location for MYCT1 Gene

Start:
152,697,895 bp from pter
End:
152,724,582 bp from pter
Size:
26,688 bases
Orientation:
Plus strand

Genomic View for MYCT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCT1 Gene

Regulatory Elements for MYCT1 Gene

Proteins for MYCT1 Gene

  • Protein details for MYCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N699-MYCT1_HUMAN
    Recommended name:
    Myc target protein 1
    Protein Accession:
    Q8N699
    Secondary Accessions:
    • Q8N396
    • Q8TBE8
    • Q9H763

    Protein attributes for MYCT1 Gene

    Size:
    235 amino acids
    Molecular mass:
    26593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYCT1 Gene

Proteomics data for MYCT1 Gene at MOPED

Post-translational modifications for MYCT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYCT1 Gene

Domains for MYCT1 Gene

Protein Domains for MYCT1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MYCT1_HUMAN
Family:
  • Belongs to the MYCT1 family.:
    • Q8N699
genes like me logo Genes that share domains with MYCT1: view

No data available for Gene Families for MYCT1 Gene

Function for MYCT1 Gene

Molecular function for MYCT1 Gene

UniProtKB/Swiss-Prot Function: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).

Phenotypes for MYCT1 Gene

GenomeRNAi human phenotypes for MYCT1:
genes like me logo Genes that share phenotypes with MYCT1: view

miRNA for MYCT1 Gene

miRTarBase miRNAs that target MYCT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYCT1 Gene

Localization for MYCT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCT1 Gene

Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCT1 Gene COMPARTMENTS Subcellular localization image for MYCT1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MYCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYCT1: view

Pathways for MYCT1 Gene

genes like me logo Genes that share pathways with MYCT1: view

Pathways by source for MYCT1 Gene

1 BioSystems pathway for MYCT1 Gene

Interacting Proteins for MYCT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356214%0d%0a9606.ENSP00000367207%0d%0a9606.ENSP00000351490%0d%0a
Selected Interacting proteins: ENSP00000356214 for MYCT1 Gene via STRING

Gene Ontology (GO) - Biological Process for MYCT1 Gene

None

Transcripts for MYCT1 Gene

Unigene Clusters for MYCT1 Gene

Myc target 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCT1 Gene

No ASD Table

Relevant External Links for MYCT1 Gene

GeneLoc Exon Structure for
MYCT1
ECgene alternative splicing isoforms for
MYCT1

Expression for MYCT1 Gene

mRNA expression in normal human tissues for MYCT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCT1 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYCT1 Gene

SOURCE GeneReport for Unigene cluster for MYCT1 Gene Hs.18160

mRNA Expression by UniProt/SwissProt for MYCT1 Gene

Q8N699-MYCT1_HUMAN
Tissue specificity: Down-regulated in gastric cancer tissues
genes like me logo Genes that share expressions with MYCT1: view

Orthologs for MYCT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCT1 36
  • 99.43 (n)
  • 99.15 (a)
MYCT1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYCT1 36
  • 86.32 (n)
  • 84.21 (a)
MYCT1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYCT1 36
  • 86.84 (n)
  • 83.69 (a)
MYCT1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myct1 36
  • 84.85 (n)
  • 85.56 (a)
Myct1 16
Myct1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYCT1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCT1 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myct1 36
  • 85.92 (n)
  • 87.7 (a)
chicken
(Gallus gallus)
Aves MYCT1 36
  • 69.53 (n)
  • 69.35 (a)
MYCT1 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCT1 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myct1 36
  • 65.07 (n)
  • 65.43 (a)
zebrafish
(Danio rerio)
Actinopterygii myct1 36
  • 49.1 (n)
  • 43.01 (a)
myct1 37
  • 36 (a)
OneToMany
MYCT1 (2 of 2) 37
  • 29 (a)
OneToMany
Species with no ortholog for MYCT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCT1 Gene

ENSEMBL:
Gene Tree for MYCT1 (if available)
TreeFam:
Gene Tree for MYCT1 (if available)

Paralogs for MYCT1 Gene

No data available for Paralogs for MYCT1 Gene

Variants for MYCT1 Gene

Sequence variations from dbSNP and Humsavar for MYCT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1001166 -- 152,702,630(+) GGCAT(A/G)GGATG intron-variant
rs1159357 -- 152,708,165(-) aaata(C/T)tactg intron-variant
rs1282451 -- 152,724,778(+) TGAAT(A/G)GACTG downstream-variant-500B
rs1282452 -- 152,708,666(-) aaata(C/T)atttt intron-variant
rs1282454 -- 152,706,502(-) AAGGC(A/T)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYCT1 Gene

Variant ID Type Subtype PubMed ID
nsv5546 CNV Loss 18451855
nsv508435 CNV Loss 20534489
esv2463453 CNV Deletion 19546169
esv2228317 CNV Deletion 18987734
nsv511919 CNV Loss 21212237
esv4043 CNV Deletion 18987735
esv2732910 CNV Deletion 23290073
esv2660075 CNV Deletion 23128226
nsv499526 CNV Loss 21111241
nsv348864 CNV Loss 16902084
esv8713 CNV Loss 19470904

Relevant External Links for MYCT1 Gene

HapMap Linkage Disequilibrium report
MYCT1

Disorders for MYCT1 Gene

(1) University of Copenhagen DISEASES for MYCT1 Gene

Relevant External Links for MYCT1

Genetic Association Database (GAD)
MYCT1
Human Genome Epidemiology (HuGE) Navigator
MYCT1
genes like me logo Genes that share disorders with MYCT1: view

No data available for UniProtKB/Swiss-Prot for MYCT1 Gene

Publications for MYCT1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Cloning and characterization of MTLC, a novel gene in 6q25. (PMID: 12673574) Qiu G.-B. … Sun K.-L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003) 3 4
  3. Expression of MTLC gene in gastric carcinoma. (PMID: 14562369) Qiu G.-B. … Sun K.-L. (World J. Gastroenterol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MYCT1 Gene

Sources for MYCT1 Gene

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