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Aliases for MYCNOS Gene

Subcategory (RNA class) for MYCNOS Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MYCNOS Gene

  • MYCN Opposite Strand 2 3
  • MYCN Opposite Strand/Antisense RNA (Non-Protein Coding) 2 3
  • MYCN Antisense RNA 1 2 3
  • NCYM 3 4
  • V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Opposite Strand 2
  • V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived Opposite Strand 3
  • DNA Binding Transcriptional Activator 2
  • MYCN Opposite Strand/Antisense RNA 2
  • N-Myc Opposite Strand 4
  • MYCN-AS1 3
  • N-CYM 3
  • NYCM 3
  • CYMN 4

External Ids for MYCNOS Gene

Previous GeneCards Identifiers for MYCNOS Gene

  • GC02M016101
  • GC02M016026
  • GC02U900920
  • GC02M015998
  • GC02M016061

Summaries for MYCNOS Gene

Entrez Gene Summary for MYCNOS Gene

  • This gene is located on the opposite strand of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (GeneID 4613). Transcription of this antisense gene may influence the progression of neuroblastoma by inhibiting transcription of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog. This gene is represented as non-coding pending further experimental evidence of a protein product. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2014]

GeneCards Summary for MYCNOS Gene

MYCNOS (MYCN Opposite Strand) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MYCNOS include neuroblastoma and autonomic nervous system neoplasm.

UniProtKB/Swiss-Prot for MYCNOS Gene

  • Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at Ser-9 (PubMed:24391509).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCNOS Gene

Genomics for MYCNOS Gene

Regulatory Elements for MYCNOS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYCNOS Gene

Chromosome:
2
Start:
15,921,037 bp from pter
End:
15,942,249 bp from pter
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for MYCNOS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYCNOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCNOS Gene

Proteins for MYCNOS Gene

  • Protein details for MYCNOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40205-NCYM_HUMAN
    Recommended name:
    N-cym protein
    Protein Accession:
    P40205
    Secondary Accessions:
    • Q53TD4

    Protein attributes for MYCNOS Gene

    Size:
    109 amino acids
    Molecular mass:
    11733 Da
    Quaternary structure:
    • Interacts with MYCN and GSK3B.

neXtProt entry for MYCNOS Gene

Proteomics data for MYCNOS Gene at MOPED

Post-translational modifications for MYCNOS Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYCNOS Gene

Domains & Families for MYCNOS Gene

Gene Families for MYCNOS Gene

Protein Domains for MYCNOS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MYCNOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYCNOS: view

No data available for UniProtKB/Swiss-Prot for MYCNOS Gene

Function for MYCNOS Gene

Molecular function for MYCNOS Gene

UniProtKB/Swiss-Prot Function:
Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at Ser-9 (PubMed:24391509).

Gene Ontology (GO) - Molecular Function for MYCNOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24391509
genes like me logo Genes that share ontologies with MYCNOS: view

Phenotypes for MYCNOS Gene

genes like me logo Genes that share phenotypes with MYCNOS: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYCNOS Gene

Localization for MYCNOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCNOS Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for MYCNOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24391509
GO:0005737 cytoplasm IDA 24391509
genes like me logo Genes that share ontologies with MYCNOS: view

No data available for Subcellular locations from COMPARTMENTS for MYCNOS Gene

Pathways & Interactions for MYCNOS Gene

SuperPathways for MYCNOS Gene

No Data Available

Interacting Proteins for MYCNOS Gene

Gene Ontology (GO) - Biological Process for MYCNOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 1419902
GO:0008284 positive regulation of cell proliferation IMP 24391509
GO:0031647 regulation of protein stability IMP 24391509
GO:0033673 negative regulation of kinase activity IDA 24391509
GO:0043066 negative regulation of apoptotic process IMP 24391509
genes like me logo Genes that share ontologies with MYCNOS: view

No data available for Pathways by source and SIGNOR curated interactions for MYCNOS Gene

Drugs & Compounds for MYCNOS Gene

(1) Drugs for MYCNOS Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arginine Nutra 346
genes like me logo Genes that share compounds with MYCNOS: view

Transcripts for MYCNOS Gene

mRNA/cDNA for MYCNOS Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYCNOS Gene

MYCN opposite strand/antisense RNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCNOS Gene

No ASD Table

Relevant External Links for MYCNOS Gene

GeneLoc Exon Structure for
MYCNOS
ECgene alternative splicing isoforms for
MYCNOS

Expression for MYCNOS Gene

mRNA expression in normal human tissues for MYCNOS Gene

mRNA differential expression in normal tissues according to GTEx for MYCNOS Gene

This gene is overexpressed in Testis (x11.9).

SOURCE GeneReport for Unigene cluster for MYCNOS Gene Hs.651453

mRNA Expression by UniProt/SwissProt for MYCNOS Gene

P40205-NCYM_HUMAN
Tissue specificity: Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.
genes like me logo Genes that share expression patterns with MYCNOS: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MYCNOS Gene

Orthologs for MYCNOS Gene

Evolution for MYCNOS Gene

ENSEMBL:
Gene Tree for MYCNOS (if available)
TreeFam:
Gene Tree for MYCNOS (if available)

No data available for Orthologs for MYCNOS Gene

Paralogs for MYCNOS Gene

No data available for Paralogs for MYCNOS Gene

Variants for MYCNOS Gene

Sequence variations from dbSNP and Humsavar for MYCNOS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10173329 -- 15,937,614(+) ctcct(C/T)ctttt intron-variant
rs10929400 -- 15,937,643(+) TATTC(C/T)GCCTC intron-variant
rs12466146 -- 15,937,077(+) GGTAA(C/T)TTATA nc-transcript-variant
rs12478025 -- 15,937,166(+) CATGG(C/T)GTACC nc-transcript-variant
rs12614550 -- 15,938,103(+) TTATC(C/T)TTCTA intron-variant

Relevant External Links for MYCNOS Gene

HapMap Linkage Disequilibrium report
MYCNOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MYCNOS Gene

Disorders for MYCNOS Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYCNOS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
- elite association

Relevant External Links for MYCNOS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCNOS
genes like me logo Genes that share disorders with MYCNOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYCNOS Gene

Publications for MYCNOS Gene

  1. Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. (PMID: 1419902) Armstrong B.C. … Krystal G.W. (Cell Growth Differ. 1992) 2 23 67
  2. NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3I^ resulting in the stabilization of MYCN in human neuroblastomas. (PMID: 24391509) Suenaga Y. … Nakagawara A. (PLoS Genet. 2014) 2 67
  3. Regulation of MYCN expression in human neuroblastoma cells. (PMID: 19615087) Jacobs J.F. … de Brouwer A.P. (BMC Cancer 2009) 2 67
  4. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. (PMID: 18285465) Steger D.J. … Vakoc C.R. (Mol. Cell. Biol. 2008) 23 67
  5. Episomal amplification of MYCN in a case of medulloblastoma. (PMID: 18286303) Surace C. … Storlazzi C.T. (Virchows Arch. 2008) 23 67

Products for MYCNOS Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MYCNOS
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MYCNOS
    • Block miRNA regulation of MYCNOS using miScript Target Protectors

    Sources for MYCNOS Gene

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