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MYCNOS Gene

RNA gene   GIFtS: 32
GCID: GC02M016061

MYCN Opposite Strand

(Previous names: v-myc myelocytomatosis viral related oncogene, neuroblastoma...)
  See MYCNOS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 3

Aliases
MYCN Opposite Strand1 2     V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived
(Avian) Opposite Strand1
NCYM2 3 5     MYCN-AS12
DNA Binding Transcriptional Activator1     N-CYM2
MYCN Antisense RNA 11     NYCM2
MYCN Opposite Strand/Antisense RNA1     CYMN3
MYCN Opposite Strand/Antisense RNA (Non-Protein Coding)1     N-Myc Opposite Strand3

External Ids:    HGNC: 169111   Entrez Gene: 104082   Ensembl: ENSG000002337187   OMIM: 6053745   UniProtKB: P402053   
ORGUL members:         

Export aliases for MYCNOS gene to outside databases

Previous GC identifers: GC02M016101 GC02M016026 GC02U900920 GC02M015998 GC02M015931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYCNOS Gene:
This gene is located on the opposite strand of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived
homolog (GeneID 4613). Transcription of this antisense gene may influence the progression of neuroblastoma by
inhibiting transcription of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog. This gene
is represented as non-coding pending further experimental evidence of a protein product. Alternatively spliced
transcript variants have been described. (provided by RefSeq, Jan 2014)

GeneCards Summary for MYCNOS Gene:
MYCNOS (MYCN opposite strand) is an RNA gene, and is affiliated with the antisense RNA class. Diseases associated with MYCNOS include neuroblastoma.

UniProtKB/Swiss-Prot: NCYM_HUMAN, P40205
Function: May have a functional role during normal fetal development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYCNOS gene promoter:
         Egr-3   GR   HOXA3   Sp1   p53   GR-beta   Nkx2-5   MIF-1   HNF-4alpha1   GR-alpha   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYCNOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.3   HGNC cytogenetic band: 2p24.1

MYCNOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYCNOS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M016061:  view genomic region     (about GC identifiers)

Start:
16,061,159 bp from pter      End:
16,082,371 bp from pter
Size:
21,213 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MYCNOS

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCYM_HUMAN, P40205 (See protein sequence)
Recommended Name: N-cym protein  
Size: 109 amino acids; 11733 Da
Developmental stage: Expressed during fetal development, as well as in tumor cell lines containing amplified MYCN
loci, where it is expressed at very high levels
Secondary accessions: Q53TD4

Explore the universe of human proteins at neXtProt for MYCNOS: NX_P40205


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: P40205


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NCYM_HUMAN, P40205
Function: May have a functional role during normal fetal development

Phenotypes:
     1 GenomeRNAi human phenotype for MYCNOS:

 Increased number of cells in m 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYCNOS
Interactions:

    Search GeneGlobe Interaction Network for MYCNOS

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007275multicellular organismal development TAS1419902

Find genes that share ontologies with MYCNOS           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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1 Novoseek inferred chemical compound relationship for MYCNOS gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
arginine 18.4 1 15479858 (1)



Find genes that share compounds with MYCNOS           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYCNOS gene: 
NM_006316.1  

Unigene Cluster for MYCNOS:

MYCN opposite strand/antisense RNA
Hs.651453  [show with all ESTs]
Unigene Representative Sequence: BC002892
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000453400(antisense) ENST00000420452(antisense) ENST00000419083(antisense) ENST00000439180(antisense) ENST00000448719(antisense)

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Additional mRNA sequence: 

BC002892.2 NR_026766.1 S49953.1 

3 DOTS entries:

DT.308870  DT.91984799  DT.100662874 

10 AceView cDNA sequences:

AI919407 BC002892 BX279550 AA609982 S49953 AI825188 AI949571 BE791907 
AW301222 AA725850 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MYCNOS:none

MYCNOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MYCNOS Expression
About this image

MYCNOS Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.651453

UniProtKB/Swiss-Prot: NCYM_HUMAN, P40205
Tissue specificity: Expressed in the fetal brain, lung, liver and kidney at varying low levels

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for MYCNOS (if available)
TreeFam Gene Tree for MYCNOS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MYCNOS
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605374    OMIM disorders: --

1 disease for MYCNOS:    
About MalaCards
neuroblastoma


Find genes that share disorders with MYCNOS           About GenesLikeMe

1 Novoseek inferred disease relationship for MYCNOS gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 2 1419902 (2)


Export disorders for MYCNOS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYCNOS gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with MYCNOS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. (PubMed id 1419902)1, 2, 3, 9 Armstrong B.C. and Krystal G.W. (Cell Growth Differ. 1992)
  2. NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3I^ resulting in the stabilization of MYCN in human neuroblastomas. (PubMed id 24391509)1, 3 Suenaga Y....Nakagawara A. (PLoS Genet. 2014)
  3. Regulation of MYCN expression in human neuroblastoma cells. (PubMed id 19615087)1, 3 Jacobs J.F....de Brouwer A.P. (BMC Cancer 2009)
  4. Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype? (PubMed id 12880964)1, 3 Scott D....Lunec J. (Cancer Lett. 2003)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding. (PubMed id 1437156)9 Rao V.N. and Reddy E.S. (Oncogene 1992)
  8. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. (PubMed id 18285465)9 Steger D.J....Vakoc C.R. (Mol. Cell. Biol. 2008)
  9. Episomal amplification of MYCN in a case of medulloblastoma. (PubMed id 18286303)9 Surace C....Storlazzi C.T. (Virchows Arch. 2008)
  10. TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. (PubMed id 15897893)9 Weiss C....GAPttlicher M. (Oncogene 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10408 HGNC: 16911 AceView: MYCNOS Ensembl:ENSG00000233718 euGenes: HUgn10408
ECgene: MYCNOS H-InvDB: MYCNOS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYCNOS Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MYCNOS Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYCNOS gene:
Search GeneIP for patents involving MYCNOS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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