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MYCN Gene

protein-coding GIFtS: 63

GC02P016032

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
(Previous names: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NMYC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MODED ^², ⁵
N-myc ^¹, ²
NMYC ^², ³, ⁵
ODED ^², ⁵
bHLHe37 ^¹, ²
pp65/67 ^²

Descriptions
N-myc proto-oncogene protein ^²
neuroblastoma MYC oncogene ^²
neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene ^²
oncogene NMYC ^²
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived ^¹, ²
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived ^²
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) ^²

External Ids
HGNC: 7559¹
Entrez Gene: 4613²
UniProtKB: P04198³
Ensembl: ENSG00000134323⁷

Search outside databases for aliases for MYCN gene

Previous GC identifers: GC02P016084 GC02P016102

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MYCN:

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH)

domain. This protein is located in the nucleus and must dimerize with another bHLH protein in

order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably

neuroblastomas. [provided by RefSeq]

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198

Function: May function as a transcription factor

Gene Wiki entry for MYCN (N-Myc)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYCN gene

Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.3 HGNC cytogenetic band: 2p24.3

MYCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P016032: (about GC identifiers)

Start:	15,998,134 bp from pter
End:	16,004,580 bp from pter
Size:	6,447 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198 (See protein sequence)

Recommended Name: N-myc proto-oncogene protein

Size: 464 amino acids; 49561 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an

heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1

Subcellular location: Nucleus

Developmental stage: Expressed during fetal development

Secondary accessions: Q6LDT9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005369.2

ENSEMBL proteins:

ENSP00000281043 ENSP00000379356

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (n-Myc)
	Human Recombinant Proteins from Abnova (MYCN)

OriGene Purified Recombinant Human Protein: MYCN

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	TAS	3796607
GO:0005634	nucleus	IDA	10597290

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Antibodies for MYCN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MYCN
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MYCN
	Antibodies from Abcam (n-Myc), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MYCN)
	Novus Biologicals Antibodies for MYCN

Assays for MYCN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04198

ProtoNet protein and cluster: P04198

2 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB002418 Myc proto-oncogene signature

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYCN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYCN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005378

Applied Biosystems Silencer® siRNAs for MYCN

Sigma-Aldrich siRNA for MYCN

Sigma-Aldrich shRNA for MYCN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MYCN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005378
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005378
untagged cDNA clone in CMV expression vector: NM_005378

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005378

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198

Function: May function as a transcription factor

Genatlas biochemistry entry for MYCN:

avian myelocytomatosis viral (v-myc) oncogene homolog,neuroblastoma derived,amplified in

retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poor prognosis

15/20 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Mycn) (see all 20 ):

	behavior/neurological	craniofacial	digestive/alimentary	embryogenesis
growth/size	hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
limbs/digits/tail	liver/biliary system	muscle	nervous system	normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	3796607
GO:0005515	protein binding	IPI	10597290 11593398

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for MYCN (Your Favorite Gene powered by Ingenuity)

ERK/MAPK Signaling

GeneDecks MYCN for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MYCN

5/84 Interacting proteins for MYCN (ENSP00000281043³ P04198²) via UniProtKB, MINT, and/or STRING (see all 84 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN2A	Q8N726²	STRING (score=.966) MINT-4648228 MINT-4648205 MINT-4648189
NDRG1	ENSP00000319977³	STRING (score=.99)
NMI	ENSP00000243346³	STRING (score=.985)
NDRG2	ENSP00000298687³	STRING (score=.983)
CD44	ENSP00000278385³	STRING (score=.964)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	3796607

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MYCN
10/15 Novoseek chemical compound relationships for MYCN gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine	38.10	8	8761302 (2), 8622876 (2), 11306486 (1), 11433525 (1) (see all 5)
vanillylmandelic acid	29.52	2	2196987 (1)
catecholamine	29.04	7	2262866 (1), 1727993 (1), 9815553 (1), 8843955 (1)
dbc-amp	23.05	1	1701347 (1)
leucine	17.94	3	1935896 (1), 8455937 (1), 18006809 (1)
homovanillic acid	14.46	3	2196987 (1), 8195324 (1)
oligonucleotide	14.29	6	14567977 (1), 1821655 (1), 10088728 (1), 12670915 (1) (see all 5)
glyceraldehyde 3-phosphate	11.53	1	17306077 (1)
phosphorothioate	8.35	3	17015904 (1), 10381259 (1)
tyrosine	4.25	9	15631895 (2), 8385567 (1), 9559292 (1), 12880971 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYCN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYCN)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005378

Sigma-Aldrich siRNA for MYCN

Sigma-Aldrich shRNA for MYCN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005378

REFSEQ mRNAs for MYCN gene:

NM_005378.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005378

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005378
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005378
                                 untagged cDNA clone in CMV expression vector: NM_005378

Additional cDNA sequence:

AF320053.1 AK298225.1 AK299495.1 BC002712.2 BT007384.1 CR599077.1 CR614612.1 CR624442.1

9 DOTS entries:

DT.442342 DT.97803950 DT.99962970 DT.121006873 DT.86841661 DT.100841340 DT.121006874 DT.91943526

DT.95296594

24/186 AceView cDNA sequences (see all 186 ):

AI094294 BQ070922 AW246671 BM461586 BQ069056 AA620376 BM925834 AW055194

CR599077 AI360395 AI492424 AI498972 AA960798 BU687918 BT007384 BQ069271

BQ882758 BX460336 AF320053 AI433544 AW594483 BF592778 BU175980 AI962624

highest scoring ESTs for MYCN:

AA094353 AA101681 AA548970 AA620376 AA778008 AA936627 AA960798 AI003077 AI039218 AI049927

Unigene Cluster for MYCN:

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Hs.25960 [show with all ESTs]

Unigene Representative Sequence: NM_005378

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000281043 ENST00000396041

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MYCN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYCN

¹ / ² / ³

10 probe-sets matching MYCN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2078_s_at²^{, 3}	U95-A	1	1.00	1.00	0.55	1.23	M13228	0.20	1.00	0.72	1
35158_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.80	Y00664	0.20	1.00	0.72	1
209757_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002712	0.80	1.00	0.91	1
211377_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF320053	0.60	1.00	0.82	1
234376_at²^{, 3}	U133-B	1	1.00	1.00	--	--	M55330	0.20	1.00	0.72	1
209756_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI871354	0.60	1.00	0.82	1
209757_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211377_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234376_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209756_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTATGAAAA

SOURCE GeneReport for Unigene cluster: Hs.25960

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYCN gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYCN¹	--	v-myc myelocytomatosis viral related oncogene, neuroblastoma more	89.05(n) 97.01(a)	482978 XM_540091.2 XP_540091.2
chimpanzee (Pan troglodytes)	MYCN¹	--	v-myc myelocytomatosis viral related oncogene, neuroblastoma more	99.64(n) 99.57(a)	459043 XM_001162328.1 XP_001162328.1
cow (Bos taurus)	MYCN¹	--	v-myc myelocytomatosis viral related oncogene, neuroblastoma more	87.69(n) 89.49(a)	616888 XM_869019.2 XP_874112.2
rat (Rattus norvegicus)	Mycn¹	--	v-myc myelocytomatosis viral related oncogene, neuroblastoma more	84.16(n) 86.12(a)	298894 NM_001013096.1 NP_001013114.1
mouse (Mus musculus)	Mycn^{1, 5}	12 (4.00 cM)⁵	v-myc myelocytomatosis viral related oncogene, neuroblastoma more^{1, 5}	83.51(n)¹ 85.68(a)¹	18109¹ NM_008709.2¹ NP_032735.2¹ AK011628⁵ AK144126⁵ (see all 15)

About this table Species with no ortholog for MYCN

ENSEMBL Gene Tree for MYCN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYCN gene

MYCL2² MYC² MYCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

8 NCBI SNPs in MYCN are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs922^1,2	A,C,F,H,O	16003920(+)	`GGTGAC/TGGTTG`	1	--	ut3¹ ese³		9		MN EU EA WA	1022
--	rs15260^1,2	F	16004456(+)	`TGGTGC/TATAGA`	1	--	ut3¹ ese³		2		MN	368
--	rs1048^1,2	--	16003916(+)	`CGTTGC/G/TTGACG`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs34551557^1,2	--	15996638(+)	`CGGGG-/TAAGCC`	1	--	ng5¹		0	--	--	--	--
--	rs62116683^1,2	--	16003728(+)	`TTTAAA/CCAAAC`	1	--	ut3¹		0	--	--	--	--
--	rs2515691^1,2	--	16004433(+)	`CTGTTA/CATGTA`	1	--	ut3¹		0	--	--	--	--
--	rs60226897^1,2	--	16004825(+)	`GCATTA/GTAGCA`	1	--	ng3¹		0	--	--	--	--
--	rs41264201^1,2	--	16004672(+)	`GTTTCC/TGTAAA`	1	--	ng3¹		0	--	--	--	--

About this table
The following additional 26 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs12692281	rs2434041	rs35648249	rs36022555	rs6741575	rs13028732	rs12621288
rs11886063	rs34819173	rs9653226	rs7577558	rs12619709	rs6751510	rs10929400
rs34421427	rs12617996	rs4669018	rs12618266	rs3755135	rs13034994	rs3755134
rs7608196	rs12987965	rs9789773	rs10929399	rs12614550

HapMap Linkage Disequilibrium images for MYCN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164840 disorders: 164280 602585

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198

Amplification of the N-MYC gene is associated with a variety of human tumors, most

frequently neuroblastoma, where the level of amplification appears to increase as the tumor

progresses

Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as

oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable

combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb

malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been

described

Defects in MYCN are the cause of microcephaly and digital abnormalities with normal

intelligence [MIM:602585]

10/70 Novoseek disease relationships for MYCN gene (see all 70 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroblastoma metastatic	79.10	4	16116152 (2), 12819037 (1), 2066755 (1)
stage neuroblastoma	74.59	4	1458508 (1), 19171715 (1), 2172598 (1)
neuroepithelioma	69.14	3	1377938 (1), 2147226 (1), 12962147 (1)
tumors	68.40	390	7674334 (8), 2196987 (5), 2066755 (5), 11107123 (4) (see all 99)
ganglioneuroblastoma	67.09	2	8454274 (2)
retinoblastoma	66.74	36	18538370 (6), 12232763 (3), 8343223 (2), 1865909 (2) (see all 20)
cerebral primitive neuroectodermal tumor	66.24	1	7889335 (1)
medulloblastoma	64.80	15	2048223 (3), 18286303 (2), 16156230 (2), 15198123 (2) (see all 10)
rhabdomyosarcoma alveolar	62.02	3	12880971 (1), 9872655 (1), 2323837 (1)
primitive neuroectodermal tumor pnet	58.88	1	7889335 (1)

About this table

Human Gene Mutation Database: MYCN
Genetic Association Database: MYCN
Tumor Gene Database: MYCN

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/488 PubMed articles for MYCN gene (see all 488 ):

Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. (PubMed id 1425701)^{1, 3, 4} Hagiwara T....Taya Y. (1992)
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. (PubMed id 18488021)^{3, 4} Zhao X....Lasorella A. (2008)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Sequence of a germ-line N-myc gene and amplification as a mechanism of activation. (PubMed id 2834684)^{3, 4} Ibson J.M. and Rabbitts P.H. (1988)
Alternative processing of RNA transcribed from NMYC. (PubMed id 3437890)^{3, 4} Stanton L.W. and Bishop J.M. (1987)
Identification and characterization of the protein encoded by the human N-myc oncogene. (PubMed id 3008339)^{3, 4} Slamon D.J....Souza L.M. (1986)
Nucleotide sequence of the human N-myc gene. (PubMed id 2869488)^{3, 4} Stanton L.W.... Bishop J.M. (1986)
Human N-myc is closely related in organization and nucleotide sequence to c-myc. (PubMed id 3510398)^{3, 4} Kohl N.E....Alt F.W. (1986)
Nucleotide sequence of the 3' exon of the human N-myc gene. (PubMed id 2987858)^{3, 4} Michitsch R.W. and Melera P.W. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4613	HGNC: 7559	AceView: MYCN	Ensembl:ENSG00000134323	euGenes: HUgn4613
ECgene: MYCN	H-InvDB: MYCN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MYCN	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=MYCN

Licensable Technologies for MYCN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MYCN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYCN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYCN		Antibodies for MYCN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYCN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MYCN)
	Antibodies (MYCN)
	Chimera RNAi (MYCN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MYCN

	Recombinant Proteins (n-Myc)
	Antibodies (n-Myc)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MYCN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MYCN

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MYCN Gene at Home site.
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MYCN Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for MYCN

Summaries
for MYCN

Genomic Location
for MYCN

Proteins
for MYCN

Protein Domains/
Families
for MYCN

Gene Function
for MYCN

Pathways & Interactions
for MYCN

Drugs & Compounds
for MYCN

Transcripts
for MYCN

Expression
for MYCN

Orthologs
for MYCN

Paralogs
for MYCN

SNPs/Variants
for MYCN

Disorders & Mutations
for MYCN

Medical News
for MYCN

Publications
for MYCN

Search for MYCN

Genome Databases showing MYCN

Other Databases showing MYCN

Specialized Databases showing MYCN

Licensable Technologies
for MYCN

Services
for MYCN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYCN Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor MYCN

Summariesfor MYCN

Genomic Locationfor MYCN

Proteinsfor MYCN

Protein Domains/Familiesfor MYCN

Gene Functionfor MYCN

Pathways & Interactionsfor MYCN

Drugs & Compoundsfor MYCN

Transcriptsfor MYCN

Expression for MYCN

Orthologsfor MYCN

Paralogsfor MYCN

SNPs/Variantsfor MYCN

Disorders & Mutationsfor MYCN

Medical Newsfor MYCN

Publicationsfor MYCN

Search for MYCN

Genome Databases showing MYCN

Other Databases showing MYCN

Specialized Databases showing MYCN

Licensable Technologiesfor MYCN

Servicesfor MYCN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYCN

Summaries
for MYCN

Genomic Location
for MYCN

Proteins
for MYCN

Protein Domains/
Families
for MYCN

Gene Function
for MYCN

Pathways & Interactions
for MYCN

Drugs & Compounds
for MYCN

Transcripts
for MYCN

Expression
for MYCN

Orthologs
for MYCN

Paralogs
for MYCN

SNPs/Variants
for MYCN

Disorders & Mutations
for MYCN

Medical News
for MYCN

Publications
for MYCN

Licensable Technologies
for MYCN

Services
for MYCN