Aliases for MYCN Gene
- MYCN Proto-Oncogene, BHLH Transcription Factor 2 3 5
- V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog 2 3
- Class E Basic Helix-Loop-Helix Protein 37 3 4
- BHLHe37 3 4
- NMYC 3 4
- Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene 3
- N-Myc Proto-Oncogene Protein 3
External Ids for MYCN Gene
Previous HGNC Symbols for MYCN Gene
Previous GeneCards Identifiers for MYCN Gene
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for MYCN Gene
MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCN include Feingold Syndrome 1 and Neuroblastoma. Among its related pathways are Notch Pathway and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MYC.
UniProtKB/Swiss-Prot for MYCN Gene
Positively regulates the transcription of MYCNOS in neuroblastoma cells.