Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYCN Gene

protein-coding   GIFtS: 65
GCID: GC02P016080

V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma...


(Previous symbol: NMYC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived
Homolog1 2
     N-myc2
NMYC1 2 3 5     N-Myc Proto-Oncogene Protein2
Class E Basic Helix-Loop-Helix Protein 372 3     Neuroblastoma MYC Oncogene2
bHLHe372 3     Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene2
MODED2 5     Oncogene NMYC2
ODED2 5     pp65/672
MYCNOT2     BHLHE373

External Ids:    HGNC: 75591   Entrez Gene: 46132   Ensembl: ENSG000001343237   OMIM: 1648405   UniProtKB: P041983   

Export aliases for MYCN gene to outside databases

Previous GC identifers: GC02P016084 GC02P016102 GC02P016032 GC02P015998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYCN Gene:
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This
protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification
of this gene is associated with a variety of tumors, most notably neuroblastomas. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYCN Gene:
MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) is a protein-coding gene. Diseases associated with MYCN include cerebral primitive neuroectodermal tumor, and feingold syndrome. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYCL.

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198
Function: May function as a transcription factor

Gene Wiki entry for MYCN (N-Myc) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYCN gene promoter:
         Egr-3   GR   Sp1   p53   GR-beta   Nkx2-5   HNF-4alpha1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYCN promoter sequence
   Search Chromatin IP Primers for MYCN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYCN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3   Ensembl cytogenetic band:  2p24.3   HGNC cytogenetic band: 2p24.3

MYCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYCN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P016080:  view genomic region     (about GC identifiers)

Start:
16,080,683 bp from pter      End:
16,087,129 bp from pter
Size:
6,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198 (See protein sequence)
Recommended Name: N-myc proto-oncogene protein  
Size: 464 amino acids; 49561 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAX. Interacts with KDM5A, KDM5B and HUWE1
Developmental stage: Expressed during fetal development
Sequence caution: Sequence=AAA36371.1; Type=Erroneous initiation; Sequence=CAA68678.1; Type=Erroneous initiation;
Secondary accessions: Q6LDT9

Explore the universe of human proteins at neXtProt for MYCN: NX_P04198

Explore proteomics data for MYCN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYCN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005369.2  
    ENSEMBL proteins: 
     ENSP00000281043  

    MYCN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MYCN
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYCN
    GenScript Custom Purified and Recombinant Proteins Services for MYCN
    Novus Biologicals MYCN Proteins
    Novus Biologicals MYCN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYCN

    MYCN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYCN
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MYCN  (N-Myc)
    OriGene Antibodies for MYCN
    OriGene Custom Antibody Services for MYCN
    Novus Biologicals MYCN Antibodies
    Abcam antibodies for MYCN
    Cloud-Clone Corp. Antibodies for MYCN
    ThermoFisher Antibody for MYCN
    LSBio Antibodies in human, mouse, rat for MYCN

    MYCN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYCN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYCN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYCN
    Cloud-Clone Corp. CLIAs for MYCN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR012682 Tscrpt_reg_Myc_N
     IPR011598 bHLH_dom
     IPR002418 Tscrpt_reg_Myc

    Graphical View of Domain Structure for InterPro Entry P04198

    ProtoNet protein and cluster: P04198

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002418 Myc proto-oncogene signature


    UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYCN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYCN_HUMAN, P04198
    Function: May function as a transcription factor

         Genatlas biochemistry entry for MYCN:
    avian myelocytomatosis viral (v-myc) oncogene homolog,neuroblastoma derived,amplified in
    retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poor prognosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10597290
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10597290
    GO:0046983protein dimerization activity IEA--
         
    MYCN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYCN:
     Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Mycn) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 

    MYCN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYCN: Mycntm1Knd Mycntm1Jrt Mycntm1Fwa Mycntm1.1Psk Mycntm1Par

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYCN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYCN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYCN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYCN

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MYCN (see all 248):
    ABCC4,  ABCD4,  ADCK1,  ADPGK,  ALDH6A1,  ANKRD12,  ANPEP,  APCDD1L,  ARHGAP12,  ARHGEF10

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GNCCACGTGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYCN:
    hsa-mir-29a-3p (MIRT006135), hsa-let-7e-5p (MIRT032100), hsa-mir-29c-3p (MIRT020415), hsa-mir-34a-5p (MIRT000980), hsa-mir-202-3p (MIRT016613), hsa-mir-29b-3p (MIRT027239), hsa-mir-19a-3p (MIRT031308), hsa-mir-34c-5p (MIRT006225), hsa-mir-19b-3p (MIRT031210), hsa-mir-101-3p (MIRT000378), hsa-mir-34b-3p (MIRT006224)

    Block miRNA regulation of human, mouse, rat MYCN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYCN (see all 100):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMYCN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYCN
    Predesigned siRNA for gene silencing in human, mouse, rat MYCN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYCN

    Clone
    Products:
         
    OriGene clones in human, mouse for MYCN (see all 6)
    OriGene ORF clones in mouse, rat for MYCN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYCN (NM_005378)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYCN
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYCN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYCN_HUMAN, P04198: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS3796607
    GO:0005634nucleus IDA10597290

    MYCN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYCN About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Notch Pathway
    Notch Pathway
    3Neuroscience
    Neuroscience
    4Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MYCN
        Apoptosis and Autophagy
    Neuroscience

    1 Tocris Bioscience Pathway for MYCN
        Notch Pathway


    1 Kegg Pathway  (Kegg details for MYCN):
        Transcriptional misregulation in cancer


    MYCN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MYCN: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYCN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYCN (P041981, 2, 3 ENSP000002810434) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AQ8N7261, 2, 3, ENSP000003551534EBI-878369,EBI-625922 MINT-4648228 MINT-4648205 MINT-4648189 I2D: score=1 STRING: ENSP00000355153
    NMIQ132871, 3, ENSP000002433464EBI-878369,EBI-372942 I2D: score=4 STRING: ENSP00000243346
    AURKAO149651, 3, ENSP000002169114EBI-878369,EBI-448680 I2D: score=2 STRING: ENSP00000216911
    MAXP612441, 3, ENSP000003514904EBI-878369,EBI-751711 I2D: score=7 STRING: ENSP00000351490
    CSNK2A2P197843, ENSP000002625064I2D: score=2 STRING: ENSP00000262506
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS3796607
    GO:0008284positive regulation of cell proliferation ----

    MYCN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYCN

    Selected Novoseek inferred chemical compound relationships for MYCN gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 62.8 64 18949372 (5), 12700651 (4), 7656409 (4), 9570357 (4) (see all 23)
    ornithine 36.9 8 8761302 (2), 8622876 (2), 11306486 (1), 11433525 (1) (see all 5)
    catecholamine 30.5 7 2262866 (1), 1727993 (1), 9815553 (1), 8843955 (1)
    hmba 28.8 2 8384353 (1)
    phenylacetate 28.5 1 11358817 (1)
    vanillylmandelic acid 28.3 2 2196987 (1)
    retinoid 22.5 4 12615055 (1), 19212680 (1)
    dbc-amp 22.1 1 1701347 (1)
    adriamycin 17.8 1 8174136 (1)
    paraffin 17.2 1 1394214 (1)



    MYCN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYCN gene: 
    NM_005378.4  

    Unigene Cluster for MYCN:

    V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
    Hs.25960  [show with all ESTs]
    Unigene Representative Sequence: NM_005378
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000281043(uc002rci.3 uc010yjr.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYCN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYCN (see all 100):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMYCN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYCN
    Predesigned siRNA for gene silencing in human, mouse, rat MYCN
    Clone
    Products:
         
    OriGene clones in human, mouse for MYCN (see all 6)
    OriGene ORF clones in mouse, rat for MYCN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYCN (NM_005378)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MYCN
    OriGene qSTAR qPCR primer pairs in human, mouse for MYCN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYCN
      QuantiTect SYBR Green Assays in human, mouse, rat MYCN
      QuantiFast Probe-based Assays in human, mouse, rat MYCN

    Additional mRNA sequence: 

    AF320053.1 AK298225.1 AK299495.1 BC002712.2 BT007384.1 

    9 DOTS entries:

    DT.442342  DT.97803950  DT.99962970  DT.121006873  DT.86841661  DT.95296594  DT.100841340  DT.121006874 
    DT.91943526 

    Selected AceView cDNA sequences (see all 186):

    AI094294 BQ069056 BU176221 BX460336 AW594483 N57026 AF320053 AI357268 
    BM461586 AI498972 BT007384 AI498620 AA960798 NM_005378 BU687918 CR599077 
    AI360395 BX458224 BE382701 CR614612 BQ069271 BU186438 BU175980 AI003077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYCN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATGAAAA
    MYCN Expression
    About this image


    MYCN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 8 entries
             Inner Cell Mass Cells Inner Cell Mass
             hIPS1
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Distal Lung Epithelial Cells Terminal Sacs
    MYCN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYCN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25960
        Pathway & Disease-focused RT2 Profiler PCR Array including MYCN: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MYCN
    OriGene qSTAR qPCR primer pairs in human, mouse for MYCN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYCN
    QuantiTect SYBR Green Assays in human, mouse, rat MYCN
    QuantiFast Probe-based Assays in human, mouse, rat MYCN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MYCN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mycn1 , 5 v-myc myelocytomatosis viral related oncogene, neuroblastoma more1, 5 82.79(n)1
    84.82(a)1
      12 (6.14 cM)5
    181091  NM_008709.31  NP_032735.31 
     129360965 
    chicken
    (Gallus gallus)
    Aves MYCN1 v-myc myelocytomatosis viral related oncogene, neuroblastoma more 72.32(n)
    72.79(a)
      421948  NM_001031091.1  NP_001026262.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYCN6
    v-myc avian myelocytomatosis viral oncogene neurob...
    54(a)
    1 ↔ 1
    1(144257648-144264853)
    African clawed frog
    (Xenopus laevis)
    Amphibia mycn-prov2 v-myc myelocytomatosis viral related oncogene, neuroblastoma more 79.88(n)    BC043747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb57a022 Danio rerio cDNA clone IMAGE6788938, partial cds 78.73(n)    BC059793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dm6
    diminutive
    11(a)
    1 → many
    X(3267192-3285730)


    ENSEMBL Gene Tree for MYCN (if available)
    TreeFam Gene Tree for MYCN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYCN gene
    MYCL2  MYC2  
    2 SIMAP similar genes for MYCN using alignment to 3 protein entries:     MYCN_HUMAN (see all proteins):
    N-myc    MYC

    MYCN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYCN
    PGOHUM00000250040


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYCN (see all 164)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0319544
    Feingold syndrome 1 (FGLDS1)4--see VAR_0319542 R H mis40--------
    VAR_0319524
    Feingold syndrome 1 (FGLDS1)4--see VAR_0319522 R H mis40--------
    VAR_0319534
    Feingold syndrome 1 (FGLDS1)4--see VAR_0319532 R S mis40--------
    rs1139941151,2
    Cpathogenic116050470(+) GCTCCG/TAGCCC 2 E * stg10--------
    rs1048936471,2
    Cpathogenic116054069(+) GCCAGA/CGCCGC 2 S R mis10--------
    rs1048936461,2
    Cpathogenic116054070(+) CCAGCA/GCCGCA 2 H R mis10--------
    rs1048936481,2
    Cpathogenic116054073(+) GCGCCA/GCAACG 2 H R mis10--------
    rs1444284011,2
    --16046838(+) ACAAAC/TGGAGG 1 -- us2k10--------
    rs1484098521,2
    --16047163(+) ATCCTC/GCTCCT 1 -- us2k10--------
    rs1452871671,2
    C--16047204(+) GGGGGC/TGATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYCN (16080683 - 16087129 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYCN: --
    Human Gene Mutation Database (HGMD): MYCN
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing MYCN:
    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing MYCN
    DNA2.0 Custom Variant and Variant Library Synthesis for MYCN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 164840   
    OMIM disorders: 164280  
    UniProtKB/Swiss-Prot: MYCN_HUMAN, P04198
  • Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently
    neuroblastoma, where the level of amplification appears to increase as the tumor progresses
  • Feingold syndrome 1 (FGLDS1) [MIM:164280]: A syndrome characterized by variable combinations of
    esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations.
    Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly
    (characteristically between second and third and fourth and fifth toes), and shortened or absent middle
    phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for MYCN (see all 81):    
    About MalaCards
    cerebral primitive neuroectodermal tumor    feingold syndrome    chromosome 17p deletion    ganglioneuroblastoma
    bilateral retinoblastoma    desmoplastic infantile ganglioglioma    feingold syndrome 1    differentiating neuroblastoma
    esophageal atresia/tracheoesophageal fistula    primitive neuroectodermal tumor    duodenal atresia    neuroblastoma 2
    adrenal neuroblastoma    tracheoesophageal fistula    esophageal atresia    pleuropulmonary blastoma
    intestinal atresia    neuroblastoma    supratentorial primitive neuroectodermal tumor    ganglioglioma

    5 diseases from the University of Copenhagen DISEASES database for MYCN:
    Neuroblastoma     Ganglioneuroma     Medulloblastoma     Adrenal neuroblastoma
    Rhabdomyosarcoma

    MYCN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MYCN gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroblastoma metastatic 78.3 4 16116152 (2), 12819037 (1), 2066755 (1)
    stage neuroblastoma 76.1 4 1458508 (1), 19171715 (1), 2172598 (1)
    tumors 68.8 421 7674334 (8), 2196987 (5), 2066755 (5), 11107123 (4) (see all 99)
    neuroepithelioma 68.4 3 1377938 (1), 2147226 (1), 12962147 (1)
    retinoblastoma 66.2 38 18538370 (6), 12232763 (3), 8343223 (2), 1865909 (2) (see all 21)
    medulloblastoma 66.2 16 2048223 (3), 18286303 (2), 16156230 (2), 15198123 (2) (see all 11)
    ganglioneuroblastoma 66.1 2 8454274 (2)
    cerebral primitive neuroectodermal tumor 65.7 1 7889335 (1)
    rhabdomyosarcoma alveolar 65.7 3 12880971 (1), 9872655 (1), 2323837 (1)
    primitive neuroectodermal tumor pnet 63.1 1 7889335 (1)

    GeneTests: MYCN
    GeneReviews: MYCN
    Genetic Association Database (GAD): MYCN
    Human Genome Epidemiology (HuGE) Navigator: MYCN (11 documents)
    Tumor Gene Database (TGDB): MYCN

    Export disorders for MYCN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYCN gene, integrated from 10 sources (see all 635):
    (articles sorted by number of sources associating them with MYCN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. (PubMed id 1425701)1, 2, 9 Hagiwara T....Taya Y. (Eur. J. Biochem. 1992)
    2. Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. (PubMed id 20332316)1, 4 Williams R.D.... . (Clin. Cancer Res. 2010)
    3. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    4. The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. (PubMed id 18488021)1, 2 Zhao X.... Lasorella A. (Nat. Cell Biol. 2008)
    5. Expanding the clinical spectrum of MYCN-related Feingold syndrome. (PubMed id 16906565)1, 2 Teszas A.... Kellermayer R. (Am. J. Med. Genet. A 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Sequence of a germ-line N-myc gene and amplification as a mechanism of activation. (PubMed id 2834684)1, 2 Ibson J.M. and Rabbitts P.H. (Oncogene 1988)
    8. Alternative processing of RNA transcribed from NMYC. (PubMed id 3437890)1, 2 Stanton L.W. and Bishop J.M. (Mol. Cell. Biol. 1987)
    9. Nucleotide sequence of the human N-myc gene. (PubMed id 2869488)1, 2 Stanton L.W.... Bishop J.M. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    10. Identification and characterization of the protein encoded by the human N-myc oncogene. (PubMed id 3008339)1, 2 Slamon D.J....Souza L.M. (Science 1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4613 HGNC: 7559 AceView: MYCN Ensembl:ENSG00000134323 euGenes: HUgn4613
    ECgene: MYCN Kegg: 4613 H-InvDB: MYCN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYCN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYCN Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MYCN[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYCN gene:
    Search GeneIP for patents involving MYCN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MYCN
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYCN   OriGene RNAi products in human, mouse, rat for MYCN  
     OriGene qPCR primer pairs and template standards for MYCN   OriGene Protein Over-expression Lysate for MYCN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYCN  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYCN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYCN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYCN   OriGene Custom Protein Services for MYCN  

     
     
     Block miRNA regulation of human, mouse, rat MYCN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYCN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYCN Predesigned siRNA for gene silencing in human, mouse, rat MYCN
     QuantiFast Probe-based Assays in human, mouse, rat MYCN QuantiTect SYBR Green Assays in human, mouse, rat MYCN
     PCR Arrays including human, mouse, rat MYCN Search Chromatin IP Primers for MYCN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYCN  GeneGlobe Interaction Network for MYCN
     Regulatory tfbs in MYCN promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYCN GenScript cDNA clones with any tag delivered in your preferred vector for MYCN
     GenScript Custom Assay Services for MYCN GenScript Custom overexpressing Cell Line Services for MYCN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MYCN  (N-Myc)

     Search Tocris compounds for MYCN
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYCN antibodies
     MYCN proteins
     MYCN lysates
     Antibodies for MYCN
     See all of Abcam's Antibodies, Kits and Proteins for MYCN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYCN
     Antibodies for MYCN
     ELISAs for MYCN
     CLIAs for MYCN



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYCN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCN
     SwitchGear 3'UTR luciferase reporter plasmids for MYCN
     SwitchGear Promoter luciferase reporter plasmids for MYCN
     ThermoFisher Antibody for MYCN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYCN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYCN
     LSBio Antibodies in human, mouse, rat for MYCN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYCN gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4