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Aliases for MYCN Gene

Aliases for MYCN Gene

  • V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog 2 3
  • NMYC 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 37 3 4
  • BHLHe37 3 4
  • MODED 3 6
  • ODED 3 6
  • Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene 3
  • N-Myc Proto-Oncogene Protein 3
  • Neuroblastoma MYC Oncogene 3
  • Oncogene NMYC 3
  • Pp65/67 3
  • N-Myc 3

External Ids for MYCN Gene

Previous Symbols for MYCN Gene

  • NMYC

Summaries for MYCN Gene

Entrez Gene Summary for MYCN Gene

  • This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for MYCN Gene

MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCN include feingold syndrome and desmoplastic infantile ganglioglioma. Among its related pathways are Transcriptional misregulation in cancer and Neuroscience. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYC.

UniProtKB/Swiss-Prot for MYCN Gene

  • May function as a transcription factor

Gene Wiki entry for MYCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCN Gene

Genomics for MYCN Gene

Genomic Location for MYCN Gene

Start:
15,940,561 bp from pter
End:
15,947,007 bp from pter
Size:
6,447 bases
Orientation:
Plus strand

Genomic View for MYCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCN Gene

Regulatory Elements for MYCN Gene

Proteins for MYCN Gene

  • Protein details for MYCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04198-MYCN_HUMAN
    Recommended name:
    N-myc proto-oncogene protein
    Protein Accession:
    P04198
    Secondary Accessions:
    • Q53XS5
    • Q6LDT9

    Protein attributes for MYCN Gene

    Size:
    464 amino acids
    Molecular mass:
    49561 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.
    SequenceCaution:
    • Sequence=AAA36371.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68678.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYCN Gene

Proteomics data for MYCN Gene at MOPED

Post-translational modifications for MYCN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCN Gene

No data available for DME Specific Peptides for MYCN Gene

Domains for MYCN Gene

Gene Families for MYCN Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

UniProtKB/Swiss-Prot:

MYCN_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • P04198
genes like me logo Genes that share domains with MYCN: view

Function for MYCN Gene

Molecular function for MYCN Gene

GENATLAS Biochemistry: avian myelocytomatosis viral (v-myc) oncogene homolog,neuroblastoma derived,amplified in retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poor prognosis
UniProtKB/Swiss-Prot Function: May function as a transcription factor

Gene Ontology (GO) - Molecular Function for MYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10597290
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 10597290
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MYCN: view
genes like me logo Genes that share phenotypes with MYCN: view

Animal Models for MYCN Gene

MGI Knock Outs for MYCN:

Transcription Factor Targeting for MYCN Gene

Selected GeneGlobe predicted Target genes for MYCN
Targeting motifs for MYCN Gene
HOMER Transcription Factor Regulatory Elements motif MYCN
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GeoId: GSE11431

No data available for Enzyme Numbers (IUBMB) for MYCN Gene

Localization for MYCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCN Gene COMPARTMENTS Subcellular localization image for MYCN gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 3796607
GO:0005634 nucleus IDA 10597290
genes like me logo Genes that share ontologies with MYCN: view

Pathways for MYCN Gene

genes like me logo Genes that share pathways with MYCN: view

Pathways by source for MYCN Gene

1 Tocris pathway for MYCN Gene
2 Cell Signaling Technology pathways for MYCN Gene
1 KEGG pathway for MYCN Gene

Gene Ontology (GO) - Biological Process for MYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 3796607
GO:0008284 positive regulation of cell proliferation --
genes like me logo Genes that share ontologies with MYCN: view

Compounds for MYCN Gene

(40) Novoseek inferred chemical compound relationships for MYCN Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 62.8 46
ornithine 36.9 7
catecholamine 30.5 4
hmba 28.8 1
phenylacetate 28.5 1
genes like me logo Genes that share compounds with MYCN: view

Transcripts for MYCN Gene

mRNA/cDNA for MYCN Gene

Unigene Clusters for MYCN Gene

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCN Gene

No ASD Table

Relevant External Links for MYCN Gene

GeneLoc Exon Structure for
MYCN
ECgene alternative splicing isoforms for
MYCN

Expression for MYCN Gene

mRNA expression in normal human tissues for MYCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYCN Gene

SOURCE GeneReport for Unigene cluster for MYCN Gene Hs.25960

genes like me logo Genes that share expressions with MYCN: view

Orthologs for MYCN Gene

This gene was present in the common ancestor of animals.

Orthologs for MYCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCN 36
  • 99.64 (n)
  • 99.57 (a)
MYCN 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYCN 36
  • 88.73 (n)
  • 92.45 (a)
MYCN 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYCN 36
  • 89.18 (n)
  • 96.81 (a)
MYCN 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycn 36
  • 82.79 (n)
  • 84.82 (a)
Mycn 16
Mycn 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCN 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycn 36
  • 83.51 (n)
  • 85.25 (a)
chicken
(Gallus gallus)
Aves MYCN 36
  • 72.32 (n)
  • 72.79 (a)
MYCN 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCN 37
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mycn-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mycn 36
  • 62.95 (n)
  • 63.57 (a)
Str.16732 36
zebrafish
(Danio rerio)
Actinopterygii mycn 36
  • 59.92 (n)
  • 59.24 (a)
mycn 37
  • 42 (a)
OneToOne
wufb57a02 36
fruit fly
(Drosophila melanogaster)
Insecta dm 37
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 12 (a)
OneToMany
Species with no ortholog for MYCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCN Gene

ENSEMBL:
Gene Tree for MYCN (if available)
TreeFam:
Gene Tree for MYCN (if available)

Paralogs for MYCN Gene

Paralogs for MYCN Gene

Selected SIMAP similar genes for MYCN Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYCN Gene

genes like me logo Genes that share paralogs with MYCN: view

Variants for MYCN Gene

Sequence variations from dbSNP and Humsavar for MYCN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs922 -- 15,946,347(+) GGTGA(C/T)GGTTG utr-variant-3-prime
rs1048 -- 15,946,343(+) CGTTG(C/G/T)TGACG utr-variant-3-prime
rs15260 -- 15,946,883(+) TGGTG(C/T)ATAGA utr-variant-3-prime
rs2434042 -- 15,945,089(+) ccgcc(A/T)cccgg intron-variant
rs2515689 -- 15,944,945(+) GGGAA(A/G)GAAAa intron-variant

Relevant External Links for MYCN Gene

HapMap Linkage Disequilibrium report
MYCN
Human Gene Mutation Database (HGMD)
MYCN

No data available for Structural Variations from Database of Genomic Variants (DGV) for MYCN Gene

Disorders for MYCN Gene

(1) OMIM Diseases for MYCN Gene (164840)

UniProtKB/Swiss-Prot

MYCN_HUMAN
  • Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
  • Feingold syndrome 1 (FGLDS1) [MIM:164280]: A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. {ECO:0000269 PubMed:15821734, ECO:0000269 PubMed:16906565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(70) Novoseek inferred disease relationships for MYCN Gene

Disease -log(P) Hits PubMed IDs
neuroblastoma metastatic 78.3 4
stage neuroblastoma 76.1 3
tumors 68.8 214
neuroepithelioma 68.4 3
retinoblastoma 66.2 32

Relevant External Links for MYCN

GeneTests
MYCN
GeneReviews
MYCN
Genetic Association Database (GAD)
MYCN
Human Genome Epidemiology (HuGE) Navigator
MYCN
Tumor Gene Database (TGDB):
MYCN
genes like me logo Genes that share disorders with MYCN: view

Publications for MYCN Gene

  1. Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. (PMID: 1425701) Hagiwara T. … Taya Y. (Eur. J. Biochem. 1992) 3 4 23
  2. N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. (PMID: 11826111) Wartiovaara K. … Kaplan D.R. (J. Neurosci. 2002) 3 23
  3. Neuroblastoma: a single institution's experience with 128 children and an evaluation of clinical and biological prognostic factors. (PMID: 11881792) Lau L. (Pediatr Hematol Oncol 2002) 3 23
  4. Importance of Sp1 consensus motifs in the MYCN promoter. (PMID: 12219017) Inge T.H. … Bates P.J. (Surgery 2002) 3 23
  5. High level amplification of N-MYC is not associated with adverse histology or outcome in primary retinoblastoma tumours. (PMID: 12232763) Lillington D.M. … Young B.D. (Br. J. Cancer 2002) 3 23

Products for MYCN Gene

  • Addgene plasmids for MYCN

Sources for MYCN Gene

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