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Aliases for MYCN Gene

Aliases for MYCN Gene

  • V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 37 3 4
  • BHLHe37 3 4
  • NMYC 3 4
  • Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene 3
  • Neuroblastoma MYC Oncogene 3
  • Oncogene NMYC 3
  • Pp65/67 3
  • MODED 3
  • N-Myc 3
  • ODED 3

External Ids for MYCN Gene

Previous HGNC Symbols for MYCN Gene

  • NMYC

Previous GeneCards Identifiers for MYCN Gene

  • GC02P016084
  • GC02P016102
  • GC02P016032
  • GC02P015998
  • GC02P016080
  • GC02P015942
  • GC02P015943

Summaries for MYCN Gene

Entrez Gene Summary for MYCN Gene

  • This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for MYCN Gene

MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCN include feingold syndrome and ewing sarcoma. Among its related pathways are Transcriptional misregulation in cancer and Notch Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MYC.

UniProtKB/Swiss-Prot for MYCN Gene

  • Positively regulates the transcription of NCYM in neuroblastoma cells (PubMed:24391509).

Gene Wiki entry for MYCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCN Gene

Genomics for MYCN Gene

Regulatory Elements for MYCN Gene

Promoters for MYCN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYCN on UCSC Golden Path with GeneCards custom track

Genomic Location for MYCN Gene

Chromosome:
2
Start:
15,940,438 bp from pter
End:
15,947,007 bp from pter
Size:
6,570 bases
Orientation:
Plus strand

Genomic View for MYCN Gene

Genes around MYCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCN Gene

Proteins for MYCN Gene

  • Protein details for MYCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04198-MYCN_HUMAN
    Recommended name:
    N-myc proto-oncogene protein
    Protein Accession:
    P04198
    Secondary Accessions:
    • Q53XS5
    • Q6LDT9

    Protein attributes for MYCN Gene

    Size:
    464 amino acids
    Molecular mass:
    49561 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with NCYM.
    SequenceCaution:
    • Sequence=AAA36371.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68678.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYCN Gene

Proteomics data for MYCN Gene at MOPED

Post-translational modifications for MYCN Gene

  • Phosphorylated by GSK3-beta which may promote its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCN Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYCN (N-Myc)

No data available for DME Specific Peptides for MYCN Gene

Domains & Families for MYCN Gene

Gene Families for MYCN Gene

Graphical View of Domain Structure for InterPro Entry

P04198

UniProtKB/Swiss-Prot:

MYCN_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYCN: view

Function for MYCN Gene

Molecular function for MYCN Gene

GENATLAS Biochemistry:
avian myelocytomatosis viral (v-myc) oncogene homolog,neuroblastoma derived,amplified in retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poor prognosis
UniProtKB/Swiss-Prot Function:
Positively regulates the transcription of NCYM in neuroblastoma cells (PubMed:24391509).
genes like me logo Genes that share phenotypes with MYCN: view

Human Phenotype Ontology for MYCN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYCN Gene

MGI Knock Outs for MYCN:

Animal Model Products

Transcription Factor Targets for MYCN Gene

Selected GeneGlobe predicted Target genes for MYCN
Targeted motifs for MYCN Gene
HOMER Transcription Factor Regulatory Elements motif MYCN
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

No data available for Enzyme Numbers (IUBMB) and Gene Ontology (GO) - Molecular Function for MYCN Gene

Localization for MYCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCN Gene COMPARTMENTS Subcellular localization image for MYCN gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MYCN Gene

Pathways & Interactions for MYCN Gene

genes like me logo Genes that share pathways with MYCN: view

Pathways by source for MYCN Gene

1 KEGG pathway for MYCN Gene
1 Tocris pathway for MYCN Gene

SIGNOR curated interactions for MYCN Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010628 positive regulation of gene expression IDA 23308108
genes like me logo Genes that share ontologies with MYCN: view

Drugs & Compounds for MYCN Gene

(17) Drugs for MYCN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for MYCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYCN: view

Transcripts for MYCN Gene

mRNA/cDNA for MYCN Gene

Unigene Clusters for MYCN Gene

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCN Gene

No ASD Table

Relevant External Links for MYCN Gene

GeneLoc Exon Structure for
MYCN
ECgene alternative splicing isoforms for
MYCN

Expression for MYCN Gene

mRNA expression in normal human tissues for MYCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYCN Gene

This gene is overexpressed in Adipocyte (46.2) and Tlymphocyte (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYCN Gene



SOURCE GeneReport for Unigene cluster for MYCN Gene Hs.25960

mRNA Expression by UniProt/SwissProt for MYCN Gene

P04198-MYCN_HUMAN
Tissue specificity: Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
genes like me logo Genes that share expression patterns with MYCN: view

Protein tissue co-expression partners for MYCN Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MYCN Gene

Orthologs for MYCN Gene

This gene was present in the common ancestor of animals.

Orthologs for MYCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCN 36
  • 100 (a)
OneToOne
MYCN 35
  • 99.64 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia MYCN 36
  • 90 (a)
OneToOne
MYCN 35
  • 88.73 (n)
  • 92.45 (a)
dog
(Canis familiaris)
Mammalia MYCN 35
  • 89.18 (n)
  • 96.81 (a)
MYCN 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycn 16
Mycn 35
  • 82.79 (n)
  • 84.82 (a)
Mycn 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCN 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycn 35
  • 83.51 (n)
  • 85.25 (a)
chicken
(Gallus gallus)
Aves MYCN 35
  • 72.32 (n)
  • 72.79 (a)
MYCN 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCN 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mycn-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mycn 35
  • 62.95 (n)
  • 63.57 (a)
Str.16732 35
zebrafish
(Danio rerio)
Actinopterygii mycn 36
  • 42 (a)
OneToOne
mycn 35
  • 59.92 (n)
  • 59.24 (a)
wufb57a02 35
fruit fly
(Drosophila melanogaster)
Insecta dm 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for MYCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCN Gene

ENSEMBL:
Gene Tree for MYCN (if available)
TreeFam:
Gene Tree for MYCN (if available)

Paralogs for MYCN Gene

Paralogs for MYCN Gene

(2) SIMAP similar genes for MYCN Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYCN Gene

genes like me logo Genes that share paralogs with MYCN: view

Variants for MYCN Gene

Sequence variations from dbSNP and Humsavar for MYCN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_031952 Feingold syndrome 1 (FGLDS1)
VAR_031953 Feingold syndrome 1 (FGLDS1)
VAR_031954 Feingold syndrome 1 (FGLDS1)
rs3755134 -- 15,944,295(+) TTCTA(C/T)CCCAG intron-variant
rs3755135 -- 15,944,472(+) AACTG(C/T)TTATT intron-variant

Variation tolerance for MYCN Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCN Gene

HapMap Linkage Disequilibrium report
MYCN
Human Gene Mutation Database (HGMD)
MYCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYCN Gene

Disorders for MYCN Gene

MalaCards: The human disease database

(34) MalaCards diseases for MYCN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
feingold syndrome
  • digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
ewing sarcoma
  • neuroepithelioma
neuroblastoma
  • neuroblastoma 1
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search MYCN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYCN_HUMAN
  • Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses. {ECO:0000269 PubMed:2834684}.
  • Feingold syndrome 1 (FGLDS1) [MIM:164280]: A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. {ECO:0000269 PubMed:15821734, ECO:0000269 PubMed:16906565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MYCN

Genetic Association Database (GAD)
MYCN
Human Genome Epidemiology (HuGE) Navigator
MYCN
Tumor Gene Database (TGDB):
MYCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCN
genes like me logo Genes that share disorders with MYCN: view

No data available for Genatlas for MYCN Gene

Publications for MYCN Gene

  1. Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. (PMID: 1425701) Hagiwara T. … Taya Y. (Eur. J. Biochem. 1992) 3 4 23 67
  2. Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin. (PMID: 20236072) Porro A. … Perini G. (Curr. Pharm. Des. 2010) 3 23
  3. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. (PMID: 19111882) Otto T. … Eilers M. (Cancer Cell 2009) 3 23
  4. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. (PMID: 19495417) Cotterman R. … Knoepfler P.S. (PLoS ONE 2009) 3 23
  5. Regulation of MYCN expression in human neuroblastoma cells. (PMID: 19615087) Jacobs J.F. … de Brouwer A.P. (BMC Cancer 2009) 3 23

Products for MYCN Gene

Sources for MYCN Gene

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