Aliases for MYCN Gene
External Ids for MYCN Gene
Previous Symbols for MYCN Gene
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for MYCN Gene
MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCN include feingold syndrome and desmoplastic infantile ganglioglioma. Among its related pathways are Transcriptional misregulation in cancer and Neuroscience. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYC.
UniProtKB/Swiss-Prot for MYCN Gene
May function as a transcription factor