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v-myc myelocytomatosis viral oncogene homolog 2 (avian)(Previous name: v-myc avian myelocytomatosis viral oncogene homolog 2 )
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Aliases
for MYCL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Myc Myelocytomatosis Viral Oncogene Homolog 2 (Avian)1 2 | | BHLHe381 | | V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 21 |
Export aliases for MYCL2 gene to outside databasesPrevious GC identifers: GC0XP101827 GC0XP103434 GC0XP104550 GC0XP105287 GC0XP106321 GC0XP106403 |
Summaries
for MYCL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MYCL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MYCL2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYCL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22-q23 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22-q28MYCL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP106515: view genomic region
(about GC identifiers)
Start:
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106,515,694 bp from pter |
End:
|
106,519,788 bp from pter |
Size:
|
4,095 bases |
Orientation:
|
plus strand |
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Proteins
for MYCL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYCL2_HUMAN, P12525 (See
protein sequence)Recommended Name: Protein L-Myc-2 Size: 357 amino acids; 41113 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for MYCL2: NX_P12525
MYCL2 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products for MYCL2:
MYCL2 Antibody Products:
Assay Products for MYCL2: |
Protein
Domains /
Families
for MYCL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYCL2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12525ProtoNet protein and cluster: P12525 2 Blocks protein families: IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB002418 Myc proto-oncogene signature
UniProtKB/Swiss-Prot: MYCL2_HUMAN, P12525Similarity: Contains 1 bHLH (basic helix-loop-helix) domain |
Function
for MYCL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for MYCL2:avian myelocytomatosis viral (v-myc) oncogene homolog 2,expressed in adult testis
Animal Models:
|
Pathways & Interactions
for MYCL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYCL2
|
Drugs & Compounds
for MYCL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MYCL2
Search CenterWatch for drugs/clinical trials and news about MYCL2 
|
Transcripts
for MYCL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372451 ENST00000544793
3 AceView cDNA sequences: NM_005377 BV184005 BV184004
GeneLoc Exon Structure
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Expression
for MYCL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYCL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MYCL2 Protein Expression from SPIRE MOPED and PaxDB UniProtKB/Swiss-Prot: MYCL2_HUMAN, P12525Tissue specificity: Detected in adult testis
SABiosciences Custom PCR Arrays for MYCL2
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYCL2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MYCL2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYCL2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYCL2 |
Orthologs
for MYCL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MYCL2 gene from 1/2 species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC529062 |
similar to L-myc-2 protein |
75.01(n) |
|
L11363.1 |
Species with no ortholog for MYCL2
ENSEMBL Gene Tree for MYCL2 (if available)
TreeFam Gene Tree for MYCL2 (if available) |
Paralogs
for MYCL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MYCL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MYCL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MYCL2 for disorders About MalaCards
MYCL2 for disorders About GeneDecksing
OMIM gene information: 310310
OMIM disorders: --
Export disorders for MYCL2 gene to outside databases
|
Publications
for MYCL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYCL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYCL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Testis-specific expression of the human MYCL2 gene. (PubMed id 1711681)1, 2 Robertson N.G.... Morton C.C. (1991)
- Mapping and characterization of an X-linked processed gene related to MYCL1. (PubMed id 2541066)1, 2 Morton C.C.... Shows T.B. (1989)
- Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. (PubMed id 10229200)1 FitzGerald M.J....Sonenshein G.E. (1999)
- Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2. (PubMed id 10100857)1 Redolfi E....Zucchi I. (1999)
- Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner. (PubMed id 7479755)1 Atchley W.R. and Fitch W.M. (1995)
- Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. (PubMed id 2827002)1 Kaye F.... Minna J. (1988)
- The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs. (PubMed id 3054516)1 De Greve J....Minna J. (1988)
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External Searches for MYCL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MYCL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYCL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYCL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for MYCL2 gene:
Search GeneIP for patents involving MYCL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYCL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYCL2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYCL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCL2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYCL2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYCL2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYCL2 |
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| | | | Search Tocris compounds for MYCL2 |
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 | | | MYCL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MYCL2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYCL2 |
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