MYCL1 Gene
protein-coding GIFtS : 62
GC01M040133
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) (Previous names: v-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: MYCL )
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Aliases & Descriptions for MYCL1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases LMYC 1 , 2 , 3 , 5 MYCL 2 , 3 bHLHe38 1 , 2
Descriptions l-myc protein 2 l-myc-1 proto-oncogene 2 myc-related gene from lung cancer 2 oncogene lmyc 2 v-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived 1 , 2 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) 2
Search outside databases for aliases for MYCL1 genePrevious GC identifers: GC01M040392 GC01M039364 GC01M039824 GC01M039774 GC01M040030
Summaries for MYCL1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for MYCL1
Genomic Location for MYCL1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MYCL1 gene Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.3 MYCL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M040133:
(about GC identifiers )
Start:
40,133,685 bp from pter
End:
40,140,274 bp from pter
Size:
6,590 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_032977.8 Proteins for MYCL1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MYCL1_HUMAN, P12524 (See
protein sequence )Recommended Name: L-myc-1 proto-oncogene protein Size : 364 amino acids; 40313 Da
Subunit : Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as anheterodimer with MAX
Subcellular location : Nucleus
Sequence caution : Sequence=CAA30248.1; Type=Erroneous gene model prediction;
Secondary accessions : A2A2C9 Q14897 Q5QPL0 Q5QPL1 Q9NUE9Alternative splicing : 2 isoforms : P12524-1 P12524-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001028253.1 NP_001028254.1 NP_005367.1 ENSEMBL proteins: ENSP00000361902 ENSP00000361903 ENSP00000335376 ENSP00000380494 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: MYCL1 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
NAS --
About this table Antibodies for MYCL1: Assays for MYCL1:
Protein
Domains/ Families for MYCL1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P12524 ProtoNet protein and cluster: P12524
2 Blocks protein families : IPB001092 Basic helix-loop-helix dimerization domain bHLH IPB002418 Myc proto-oncogene signature UniProtKB/Swiss-Prot: MYCL1_HUMAN, P12524 Similarity : Contains 1 basic helix-loop-helix (bHLH) domain
Gene Function for MYCL1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005376 Applied Biosystems Silencer ® siRNAs for MYCL1 Sigma-Aldrich siRNA for MYCL1 Sigma-Aldrich shRNA for MYCL1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001033081                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001033081                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC030694  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001033082 Genatlas biochemistry entry for MYCL1 :avian myelocytomatosis viral (v-myc) oncogene homolog 1,lung carcinoma derived
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mycl1) :1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 transcription factor activity
NAS --
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Pathways & Interactions for MYCL1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MYCL1 5 Interacting proteins for MYCL1 (ENSP00000335376 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
NAS --
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Drugs & Compounds for MYCL1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MYCL1 2 Novoseek chemical compound relationships for MYCL1 gene
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Transcripts for MYCL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005376 Sigma-Aldrich siRNA for MYCL1 Sigma-Aldrich shRNA for MYCL1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001033081 NM_001033082 NM_005376
REFSEQ mRNAs for MYCL1 gene (3 alternative transcripts): NM_001033081.1 NM_001033082.1 NM_005376.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001033081 NM_001033082 NM_005376
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001033081                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001033081                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC030694  
Additional cDNA sequence: AK296078.1 AK296838.1 BC011864.2 BC030694.1 CR614411.1 CR624052.1
4 DOTS entries : DT.95372141 DT.40118361 DT.100694534 DT.110339
24/50 AceView cDNA sequences (see all 50
):W20405 BX092972 CR624052 CR614411 AI144219 BM126955 BX348755 BX101968 CK823460 BM967204 BF061352 AI745088 AW294639 BU633674 BC011864 AA429494 BM827119 AI470392 BM452755 BM751625 BX372020 AA428557 AL558716 BQ029183
highest scoring ESTs for MYCL1 :BC011864 BC030694 BG335397 BG720704 BI549707 BI551573 AA428557 AI131386 AI144219 AI198086
Unigene Cluster for MYCL1: V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) Hs.437922 [show with all ESTs ] Unigene Representative Sequence: NM_001033081 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000372815
ENST00000372816
ENST00000334282
ENST00000397332
Expression for MYCL1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MYCL1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MYCL1 1 / 2 / 3
7 probe-sets matching MYCL1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTTTACAAAASOURCE GeneReport for Unigene cluster: Hs.437922 Expression variation in blood from EXPOLDB for MYCL1
Orthologs for MYCL1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MYCL1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for MYCL1 ENSEMBL Gene Tree for MYCL1 Paralogs for MYCL1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MYCL1 gene MYCL2 2 MYCN 2 MYC 2
SNPs/Variants for MYCL1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MYCL1 (up to first 250kb)
Disorders & Mutations for MYCL1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 164850 10/19 Novoseek disease relationships for MYCL1 gene (see all 19
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung
59.96
29
1975565 (3), 7908608 (3), 10717329 (3), 12169206 (2) (see all 16 )
allelic imbalance
59.92
3
11956626 (1), 12527710 (1), 12378519 (1)
small cell lung cancer
49.60
8
1331597 (2), 9747881 (1), 19020549 (1), 2171744 (1) (see all 6 )
hematopoietic malignancies
48.84
1
8260894 (1)
tumors
36.54
25
12707044 (4), 10321885 (2), 2302711 (1), 2174659 (1) (see all 10 )
allelic loss
34.39
1
10717329 (1)
lung carcinoma
34.28
1
1620120 (1)
metastasis
33.98
12
1683040 (3), 1347036 (2), 1304834 (1), 12456990 (1) (see all 9 )
myeloid leukemia
31.44
1
1954386 (1)
carcinoma squamous cell
31.36
3
12527710 (1), 1690210 (1), 1970484 (1)
About this table Genetic Association Database: MYCL1 Human Genome Epidemiology Navigator: MYCL1 (12 documents)
Medical News for MYCL1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MYCL1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/89 PubMed articles for MYCL1 gene (see all 89
): EcoRI polymorphism of the L-myc gene in gastric cancer patients. (PubMed id 12439118) 1, 3, 6 Dlugosz A....Starzynska T. (2002) Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer. (PubMed id 12507230) 1, 3, 6 Isbir T....Camlica H. (2002) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) A new polymorphism (Ser362Thr) of the L-myc gene is not associated with lung adenocarcinoma risk and prognosis. (PubMed id 15075794) 3, 6 Spinola M.... Dragani T.A. (2004) Meta-analysis suggests association of L-myc EcoRI polymorphism with cancer prognosis. (PubMed id 15269151) 3, 6 Spinola M....Taioli E. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). (PubMed id 12883749) 3, 6 Xing D....Lin D. (2003) Is there any correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human nonsmall cell lung cancer? (PubMed id 12034523) 3, 6 Yaylim I....Camlica H. (2002) Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases. (PubMed id 11955646) 3, 6 Shih C.M....Wang Y.C. (2002) L-myc genotype is associated with different susceptibility to lung cancer in smokers. (PubMed id 11802801) 3, 6 Kumimoto H....Ishizaki K. (2002)
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Genome Databases showing MYCL1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MYCL1
(According to HUGE )
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Specialized Databases showing MYCL1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MYCL1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for MYCL1:
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