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MYCL1 Gene

protein-coding   GIFtS: 62

GC01M040133
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
(Previous names: v-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MYCL)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
LMYC 1, 2, 3, 5
MYCL 2, 3
bHLHe38 1, 2
Descriptions
l-myc protein 2
l-myc-1 proto-oncogene 2
myc-related gene from lung cancer 2
oncogene lmyc 2
v-myc avian myelocytomatosis viral oncogene homolog 1, lung
carcinoma derived 1, 2
v-myc myelocytomatosis viral oncogene homolog 1, lung
carcinoma derived (avian) 2
External Ids
HGNC: 75551
Entrez Gene: 46102
UniProtKB: P125243
Ensembl: ENSG000001169907
Search outside databases for aliases for MYCL1 gene

Previous GC identifers: GC01M040392 GC01M039364 GC01M039824 GC01M039774 GC01M040030

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for MYCL1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MYCL1 gene  

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.3

MYCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040133:     (about GC identifiers)

Start:
40,133,685 bp from pter
End:
40,140,274 bp from pter
Size:
6,590 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MYCL1_HUMAN, P12524 (See protein sequence)
Recommended Name: L-myc-1 proto-oncogene protein  
Size: 364 amino acids; 40313 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an
heterodimer with MAX
Subcellular location: Nucleus
Sequence caution: Sequence=CAA30248.1; Type=Erroneous gene model prediction;
Secondary accessions: A2A2C9 Q14897 Q5QPL0 Q5QPL1 Q9NUE9
Alternative splicing: 2 isoforms:  P12524-1   P12524-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001028253.1  NP_001028254.1  NP_005367.1  


    ENSEMBL proteins: 
    ENSP00000361902 ENSP00000361903 ENSP00000335376 ENSP00000380494 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (l-Myc)
    Human Recombinant Proteins from Abnova (MYCL1)
                  OriGene Purified Recombinant Human Protein: MYCL1 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    About this table

    Antibodies for MYCL1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MYCL1
    R&D Systems Antibodies for MYCL1
    Antibodies from Abcam (l-Myc), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MYCL1)
    Novus Biologicals Antibody for MYCL1

    Assays for MYCL1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001092 HLH_basic
     IPR011598 HLH_DNA_bd
     IPR012682 Tscrpt_reg_Myc_N
     IPR002418 Tscrpt_reg_Myc


       GeneDecks  MYCL1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P12524

    ProtoNet protein and cluster: P12524

    2 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002418 Myc proto-oncogene signature


    UniProtKB/Swiss-Prot: MYCL1_HUMAN, P12524
    Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MYCL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MYCL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005376

                  Applied Biosystems Silencer® siRNAs for MYCL1

                  Sigma-Aldrich siRNA for MYCL1  
                         Sigma-Aldrich shRNA for MYCL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MYCL1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033081
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033081
                                     untagged cDNA clones in CMV expression vector (see all 4): BC030694 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001033082

    Genatlas biochemistry entry for MYCL1:
    avian myelocytomatosis viral (v-myc) oncogene homolog 1,lung carcinoma derived

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mycl1):

    normal

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity NAS--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MYCL1 


    5 Interacting proteins for MYCL1 (ENSP000003353763) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBPENSP000002256983STRING (score=.967)
    MAXENSP000002841653STRING (score=.87)
    ERBB2ENSP000002695713STRING (score=.783)
    PIK3CAENSP000002639673STRING (score=.727)
    MYBENSP000003399923STRING (score=.716)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MYCL1
    2 Novoseek chemical compound relationships for MYCL1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ecori 67.82 10 12439118 (3), 7908608 (2), 1975565 (1), 1973618 (1) (see all 7)
    leucine 28.55 2 1935896 (1), 8455937 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MYCL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MYCL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005376

                  Sigma-Aldrich siRNA for MYCL1  
                         Sigma-Aldrich shRNA for MYCL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001033081  NM_001033082  NM_005376  

    REFSEQ mRNAs for MYCL1 gene (3 alternative transcripts): 

    NM_001033081.1   NM_001033082.1   NM_005376.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001033081  NM_001033082  NM_005376  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033081
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033081
                                     untagged cDNA clones in CMV expression vector (see all 4): BC030694 

    Additional cDNA sequence: 

    AK296078.1 AK296838.1 BC011864.2 BC030694.1 CR614411.1 CR624052.1 

    4 DOTS entries:

    DT.95372141  DT.40118361  DT.100694534  DT.110339 

    24/50 AceView cDNA sequences (see all 50 ):

    W20405 BX092972 CR624052 CR614411 AI144219 BM126955 BX348755 BX101968 
    CK823460 BM967204 BF061352 AI745088 AW294639 BU633674 BC011864 AA429494 
    BM827119 AI470392 BM452755 BM751625 BX372020 AA428557 AL558716 BQ029183 

    highest scoring ESTs for MYCL1:

    BC011864 BC030694 BG335397 BG720704 BI549707 BI551573 AA428557 AI131386 AI144219 AI198086 

    Unigene Cluster for MYCL1:

    V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
    Hs.437922  [show with all ESTs]
    Unigene Representative Sequence: NM_001033081


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000372815  ENST00000372816  ENST00000334282  ENST00000397332  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MYCL1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MYCL1

    1 / 2 / 3

    7 probe-sets matching MYCL1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1489_s_at2, 3 U95-A 1 1.00 1.00 0.49 0.78 M19720 0.20 1.00 0.72 1
    1490_at2, 3 U95-A 1 1.00 1.00 0.92 1.13 M19720 0.20 1.00 0.72 1

    33643_at2, 3 U95-A 1 0.69 1.00 0.90 1.13 AI198086 0.60 1.00 0.82 1

    214058_at2, 3 U133-A 1 1.00 1.00 -- -- M19720 0.20 1.00 0.72 1

    215491_at2, 3 U133-A 1 1.00 1.00 -- -- AI273812 0.40 1.00 0.76 1

    214058_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215491_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  MYCL1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTTACAAAA

    SOURCE GeneReport for Unigene cluster: Hs.437922

    Expression variation in blood from EXPOLDB for MYCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MYCL1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MYCL11   -- v-myc myelocytomatosis viral oncogene homolog 1, lung more 90.54(n)
    93.11(a)
    482461  XM_539578.2  XP_539578.2 
    chimpanzee
    (Pan troglodytes)
    MYCL11   -- v-myc myelocytomatosis viral oncogene homolog 1, lung more 99.68(n)
    99.37(a)
    469291  XM_524676.2  XP_524676.2 
    cow
    (Bos taurus)
    MYCL11   -- v-myc myelocytomatosis viral oncogene homolog 1, lung more 90.48(n)
    90.93(a)
    540350  XM_593398.3  XP_593398.3 
    rat
    (Rattus norvegicus)
    Mycl11   -- v-myc myelocytomatosis viral oncogene homolog 1, lung more 85.81(n)
    89.84(a)
    298506  XM_233490.4  XP_233490.4 
    mouse
    (Mus musculus)
    Mycl11, 5 4 (55.00 cM)5
    v-myc myelocytomatosis viral oncogene homolog 1, lung more1, 5 86.63(n)1
    90.11(a)1
    169181  NM_008506.21  NP_032532.11 
     AA1242335  AK1469595  (see all 14)
    About this table        Species with no ortholog for MYCL1

    ENSEMBL Gene Tree for MYCL1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MYCL1 gene
    MYCL22  MYCN2  MYC2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/40 NCBI SNPs in MYCL1 are shown (see all 40 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 19)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs31170881,2
    A,C,F,H40141819(+) TCAGCC/TAACCA 3 -- ng314Minor allele frequency- T:0.33EU EA WA 416
    rs31346151,2
    A,C,F,H40134653(-) CACCTG/TCCTCA 2 -- ut31 ese38Minor allele frequency- T:0.11EU EA WA NA 780
    rs31346131,2
    A,C,F,H40137390(-) CAGAAT/GTCCAA 3 -- int1 ng515Minor allele frequency- G:0.32EU EA WA NA 506
    rs31346141,2
    C,F,H40135641(-) CCTCAG/CTGGCT 2 S/T mis1 ese38Minor allele frequency- C:0.03EU EA WA 834
    rs75485241,2
    A,F,H40141492(+) GGTGTC/TTGTCT 3 -- ng31 tfbs33Minor allele frequency- T:0.30EU EA 298
    --
    rs412975931,2
    F40134370(-) CCCAGC/GTGGAC 2 -- ut311Minor allele frequency- G:0.24EU 372
    rs75352561,2
    H40136811(+) TTCACC/TCACAG 2 -- int14Minor allele frequency- T:0.00EU EA WA 412
    --
    rs31170851,2
    --40134550(+) CCCAAA/GGGTGG 2 -- ut31 ese30--------
    --
    rs726379091,2
    --40140179(+) CTCACA/GAGCGC 3 -- ut510--------
    --
    rs585877271,2
    --40141931(+) TTGTC-/GTCCTTTA 3 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for MYCL1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 164850

    10/19 Novoseek disease relationships for MYCL1 gene (see all 19 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 59.96 29 1975565 (3), 7908608 (3), 10717329 (3), 12169206 (2) (see all 16)
    allelic imbalance 59.92 3 11956626 (1), 12527710 (1), 12378519 (1)
    small cell lung cancer 49.60 8 1331597 (2), 9747881 (1), 19020549 (1), 2171744 (1) (see all 6)
    hematopoietic malignancies 48.84 1 8260894 (1)
    tumors 36.54 25 12707044 (4), 10321885 (2), 2302711 (1), 2174659 (1) (see all 10)
    allelic loss 34.39 1 10717329 (1)
    lung carcinoma 34.28 1 1620120 (1)
    metastasis 33.98 12 1683040 (3), 1347036 (2), 1304834 (1), 12456990 (1) (see all 9)
    myeloid leukemia 31.44 1 1954386 (1)
    carcinoma squamous cell 31.36 3 12527710 (1), 1690210 (1), 1970484 (1)
    About this table

    Genetic Association Database: MYCL1
    Human Genome Epidemiology Navigator: MYCL1 (12 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/89 PubMed articles for MYCL1 gene (see all 89 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4610 HGNC: 7555 AceView: MYCL1 Ensembl:ENSG00000116990 euGenes: HUgn4610
    ECgene: MYCL1 H-InvDB: MYCL1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MYCL1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MYCL1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for MYCL1-related products

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     Predesigned and custom siRNAs for MYCL1 Antibodies for MYCL1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MYCL1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for MYCL1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MYCL1

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