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Aliases for MYCL Gene

Aliases for MYCL Gene

  • V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog 2 3
  • LMYC 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 38 3 4
  • Myc-Related Gene From Lung Cancer 2 3
  • Protein L-Myc-1 3 4
  • BHLHe38 3 4
  • MYCL1 3 4
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 2
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 4
  • L-Myc-1 Proto-Oncogene 3
  • L-Myc Protein 2
  • Oncogene Lmyc 2
  • Protein L-Myc 3

External Ids for MYCL Gene

Previous HGNC Symbols for MYCL Gene

  • MYCL1

Previous GeneCards Identifiers for MYCL Gene

  • GC01M040362

Summaries for MYCL Gene

GeneCards Summary for MYCL Gene

MYCL (V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCL include lower lip cancer and lip cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYC.

Gene Wiki entry for MYCL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCL Gene

Genomics for MYCL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYCL Gene

Start:
39,895,424 bp from pter
End:
39,902,256 bp from pter
Size:
6,833 bases
Orientation:
Minus strand

Genomic View for MYCL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCL Gene

No data available for Regulatory Elements for MYCL Gene

Proteins for MYCL Gene

  • Protein details for MYCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12524-MYCL_HUMAN
    Recommended name:
    Protein L-Myc
    Protein Accession:
    P12524
    Secondary Accessions:
    • A2A2C9
    • B4DJH2
    • Q14897
    • Q5QPL0
    • Q5QPL1
    • Q9NUE9

    Protein attributes for MYCL Gene

    Size:
    364 amino acids
    Molecular mass:
    40327 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX
    SequenceCaution:
    • Sequence=AAH11864.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30248.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MYCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYCL Gene

Proteomics data for MYCL Gene at MOPED

Post-translational modifications for MYCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCL Gene

No data available for DME Specific Peptides for MYCL Gene

Domains for MYCL Gene

Gene Families for MYCL Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Graphical View of Domain Structure for InterPro Entry

P12524

UniProtKB/Swiss-Prot:

MYCL_HUMAN :
  • P12524
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYCL: view

No data available for Suggested Antigen Peptide Sequences for MYCL Gene

Function for MYCL Gene

Gene Ontology (GO) - Molecular Function for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10597290
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MYCL: view

Phenotypes for MYCL Gene

genes like me logo Genes that share phenotypes with MYCL: view

Animal Models for MYCL Gene

MGI Knock Outs for MYCL:

Animal Model Products

CRISPR Products

miRNA for MYCL Gene

miRTarBase miRNAs that target MYCL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYCL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MYCL Gene

Localization for MYCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCL Gene

Gene Ontology (GO) - Cellular Components for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MYCL: view

No data available for Subcellular locations from COMPARTMENTS for MYCL Gene

Pathways for MYCL Gene

SuperPathways for MYCL Gene

No Data Available

Interacting Proteins for MYCL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380494%0d%0a9606.ENSP00000351490%0d%0a9606.ENSP00000264444%0d%0a
Selected Interacting proteins: ENSP00000380494 P12524-MYCL_HUMAN for MYCL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MYCL: view

No data available for Pathways by source for MYCL Gene

Compounds for MYCL Gene

(2) Novoseek inferred chemical compound relationships for MYCL Gene

Compound -log(P) Hits PubMed IDs
ecori 67.8 10
leucine 28.1 2
genes like me logo Genes that share compounds with MYCL: view

Transcripts for MYCL Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYCL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYCL Gene

No ASD Table

Relevant External Links for MYCL Gene

GeneLoc Exon Structure for
MYCL
ECgene alternative splicing isoforms for
MYCL

Expression for MYCL Gene

mRNA expression in normal human tissues for MYCL Gene

mRNA differential expression in normal tissues according to GTEx for MYCL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (9.8), Skin - Not Sun Exposed (Suprapubic) (7.9), Pancreas (5.9), Bladder (5.3), and Esophagus - Mucosa (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYCL Gene

genes like me logo Genes that share expressions with MYCL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYCL Gene

Orthologs for MYCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCL 36
  • 91 (a)
OneToOne
MYCL1 35
  • 99.43 (n)
  • 98.86 (a)
cow
(Bos Taurus)
Mammalia MYCL 35
  • 90.27 (n)
  • 90.61 (a)
MYCL 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYCL 35
  • 90.59 (n)
  • 92.62 (a)
MYCL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycl 35
  • 86.26 (n)
  • 89.56 (a)
Mycl 36
  • 87 (a)
OneToOne
Mycl1 16
oppossum
(Monodelphis domestica)
Mammalia MYCL 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycl 35
  • 85.81 (n)
  • 89.84 (a)
chicken
(Gallus gallus)
Aves MYCL 36
  • 55 (a)
OneToOne
MYCL1 35
  • 65.89 (n)
  • 61.92 (a)
lizard
(Anolis carolinensis)
Reptilia MYCL 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mycl 35
  • 57.11 (n)
  • 56.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mycla 36
  • 38 (a)
OneToMany
myclb 35
  • 59.19 (n)
  • 55.11 (a)
myclb 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dm 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
OneToMany
Species with no ortholog for MYCL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCL Gene

ENSEMBL:
Gene Tree for MYCL (if available)
TreeFam:
Gene Tree for MYCL (if available)

Paralogs for MYCL Gene

Paralogs for MYCL Gene

Selected SIMAP similar genes for MYCL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYCL Gene

genes like me logo Genes that share paralogs with MYCL: view

Variants for MYCL Gene

Sequence variations from dbSNP and Humsavar for MYCL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs804719 -- 39,901,920(+) ctcac(A/G)agcgc utr-variant-5-prime
rs1800834 -- 39,897,498(-) ATCCT(A/G)AGCAA reference, synonymous-codon
rs3117084 -- 39,896,028(+) TGAGG(A/T)TACCC utr-variant-3-prime
rs3117085 -- 39,896,291(+) CCCAA(A/G)GGTGG utr-variant-3-prime
rs3117086 -- 39,896,789(+) TAATA(C/T)ATAAA utr-variant-3-prime

Relevant External Links for MYCL Gene

HapMap Linkage Disequilibrium report
MYCL
Human Gene Mutation Database (HGMD)
MYCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYCL Gene

Disorders for MYCL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for MYCL Gene including...

Search for MYCL Gene in MalaCards »

(19) Novoseek inferred disease relationships for MYCL Gene

Disease -log(P) Hits PubMed IDs
allelic imbalance 59.5 3
cancer lung 59.1 27
small cell lung cancer 49.1 7
hematopoietic malignancies 48 1
tumors 35.8 14
genes like me logo Genes that share disorders with MYCL: view

No data available for UniProtKB/Swiss-Prot for MYCL Gene

Publications for MYCL Gene

  1. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PMID: 2006410) Blackwood E.M. … Eisenman R.N. (Science 1991) 3 23
  2. Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ. (PMID: 11956626) Primdahl H. … A9rntoft T.F. (Oncol. Rep. 2002) 3 23
  3. MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. (PMID: 12169206) Demopoulos K. … Spandidos D.A. (J. Cell. Mol. Med. 2002) 3 23
  4. EcoRI polymorphism of the L-myc gene in gastric cancer patients. (PMID: 12439118) Dlugosz A. … Starzynska T. (Eur J Gastroenterol Hepatol 2002) 3 23
  5. Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer. (PMID: 12507230) Isbir T. … Camlica H. (Cancer Detect. Prev. 2002) 3 23

Products for MYCL Gene

  • Addgene plasmids for MYCL

Sources for MYCL Gene

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