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MYCL Gene

protein-coding   GIFtS: 41
GCID: GC01M040362

V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma...

(Previous names: v-myc avian myelocytomatosis viral oncogene homolog 1, lung...)
(Previous symbol: MYCL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived
Homolog1 2
     Oncogene Lmyc1
MYCL11 2 3     V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma
Derived1
LMYC2 3 5     L-Myc-1 Proto-Oncogene2
Myc-Related Gene From Lung Cancer1 2     Protein L-Myc2
Class E Basic Helix-Loop-Helix Protein 382 3     V-Myc Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived2
Protein L-Myc-12 3     BHLHE383
bHLHe382 3     V-Myc Myelocytomatosis Viral Oncogene Homolog3
L-Myc Protein1     

External Ids:    HGNC: 75551   Entrez Gene: 46102   Ensembl: ENSG000001169907   OMIM: 1648505   UniProtKB: P125243   

Export aliases for MYCL gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYCL Gene:
MYCL (v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog) is a protein-coding gene. Diseases associated with MYCL include lower lip cancer, and lip cancer. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYCN.

Gene Wiki entry for MYCL (MYCL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MYCL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYCL promoter sequence
   Search Chromatin IP Primers for MYCL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYCL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.3

MYCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYCL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040362:  view genomic region     (about GC identifiers)

Start:
40,361,096 bp from pter      End:
40,367,928 bp from pter
Size:
6,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MYCL_HUMAN, P12524 (See protein sequence)
Recommended Name: Protein L-Myc  
Size: 364 amino acids; 40327 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAX
Sequence caution: Sequence=AAH11864.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA30248.1; Type=Erroneous gene model prediction;
Secondary accessions: A2A2C9 B4DJH2 Q14897 Q5QPL0 Q5QPL1 Q9NUE9
Alternative splicing: 3 isoforms:  P12524-1   P12524-2   P12524-3   

Explore the universe of human proteins at neXtProt for MYCL: NX_P12524

Explore proteomics data for MYCL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYCL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028253.1  NP_001028254.2  NP_005367.2  

    ENSEMBL proteins: 
     ENSP00000380494   ENSP00000361903   ENSP00000361902   ENSP00000434375   ENSP00000389358  

    MYCL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MYCL
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYCL
    GenScript Custom Purified and Recombinant Proteins Services for MYCL
    Novus Biologicals MYCL Protein
    Novus Biologicals MYCL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MYCL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MYCL (MYCL1/L-Myc)
    OriGene Antibodies for MYCL
    OriGene Custom Antibody Services for MYCL
    Novus Biologicals MYCL Antibodies
    Search for Antibodies for MYCL at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MYCL
    LSBio Antibodies in human, mouse, rat for MYCL

    MYCL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYCL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYCL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR012682 Tscrpt_reg_Myc_N
     IPR011598 bHLH_dom
     IPR002418 Tscrpt_reg_Myc

    Graphical View of Domain Structure for InterPro Entry P12524

    ProtoNet protein and cluster: P12524

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002418 Myc proto-oncogene signature


    UniProtKB/Swiss-Prot: MYCL_HUMAN, P12524
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYCL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10597290
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    MYCL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYCL:
     Increased resistance to MDM2 i 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mycl1):
     hematopoietic system  immune system  mortality/aging  normal 

    MYCL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mycltm1Rdp for MYCL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYCL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYCL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYCL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYCL

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYCL:
    hsa-mir-335-5p (MIRT017404)

    Block miRNA regulation of human, mouse, rat MYCL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYCL
    SwitchGear 3'UTR luciferase reporter plasmidMYCL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYCL
    Predesigned siRNA for gene silencing in human, mouse, rat MYCL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYCL

    Clone
    Products:
         
    OriGene clones in human, mouse for MYCL (see all 17)
    OriGene ORF clones in mouse, rat for MYCL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MYCL
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCL

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MYCL
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYCL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYCL_HUMAN, P12524: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MYCL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYCL
    Interactions:

        Search GeneGlobe Interaction Network for MYCL

    2 Interacting proteins for MYCL (P125243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAXP612443I2D: score=4 
    MXD1Q051953I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----

    MYCL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYCL

    2 Novoseek inferred chemical compound relationships for MYCL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ecori 67.8 10 12439118 (3), 7908608 (2), 1975565 (1), 1973618 (1) (see all 7)
    leucine 28.1 2 1935896 (1), 8455937 (1)



    MYCL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYCL gene (3 alternative transcripts): 
    NM_001033081.2  NM_001033082.2  NM_005376.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397332(uc001cer.2 uc001ces.2) ENST00000372816 ENST00000372815
    ENST00000450953 ENST00000429311(uc001cet.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYCL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYCL
    SwitchGear 3'UTR luciferase reporter plasmidMYCL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYCL
    Predesigned siRNA for gene silencing in human, mouse, rat MYCL
    Clone
    Products:
         
    OriGene clones in human, mouse for MYCL (see all 17)
    OriGene ORF clones in mouse, rat for MYCL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MYCL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MYCL
    OriGene qSTAR qPCR primer pairs in human, mouse for MYCL
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MYCL
      QuantiTect SYBR Green Assays in human, mouse, rat MYCL
      QuantiFast Probe-based Assays in human, mouse, rat MYCL

    Selected AceView cDNA sequences (see all 50):

    BX092972 W20405 CR614411 AI144219 BF061352 AI745088 CR624052 CK823460 
    BX101968 BM967204 BM126955 BX348755 NM_005376 AL558716 BU157805 BX372020 
    AA429494 BC030694 BM452755 AW294639 AA428557 BU633674 BX956515 BM751625 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYCL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYCL Expression
    About this image

    MYCL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYCL Protein Expression
        Custom PCR Arrays for MYCL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MYCL
    OriGene qSTAR qPCR primer pairs in human, mouse for MYCL
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MYCL
    QuantiTect SYBR Green Assays in human, mouse, rat MYCL
    QuantiFast Probe-based Assays in human, mouse, rat MYCL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYCL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mycl15
    Mycl1
    v-myc myelocytomatosis viral oncogene homolog 1, lung more5
    v-myc myelocytomatosis viral oncogene homolog, lung more1
    86.26(n)1
    89.56(a)1
      4 (57.36 cM)5
    169181  NM_008506.21  NP_032532.11 
     1229956525 
    chicken
    (Gallus gallus)
    Aves MYCL11 v-myc myelocytomatosis viral oncogene homolog 1, lung more 65.89(n)
    61.92(a)
      428231  XM_425790.4  XP_425790.2 
    lizard
    (Anolis carolinensis)
    Reptilia MYCL6
    v-myc avian myelocytomatosis viral oncogene lung c...
    65(a)
    1 ↔ 1
    GL343481.1(89207-89770)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mycl1 v-myc avian myelocytomatosis viral oncogene lung carcinoma more 57.11(n)
    56.71(a)
      496561  NM_001011144.1  NP_001011144.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myclb1 v-myc avian myelocytomatosis viral oncogene lung carcinoma more 59.19(n)
    55.11(a)
      567762  NM_001045142.1  NP_001038607.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dm6
    diminutive
    9(a)
    1 → many
    X(3267192-3285730)


    ENSEMBL Gene Tree for MYCL (if available)
    TreeFam Gene Tree for MYCL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYCL gene
    MYCN2  MYC2  
    1 SIMAP similar gene for MYCL using alignment to 3 protein entries:     MYCL_HUMAN (see all proteins):
    MYCLP1

    MYCL for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MYCL
    PGOHUM00000241346 PGOHUM00000250084


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYCL (see all 186)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788480561,2
    F--40360655(+) CAGAAG/AGTCAT 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1900608751,2
    --40360773(+) AAGTAA/GCATTT 2 -- ds50010--------
    rs1158633451,2
    F--40360780(+) ATTTAT/CCCCCA 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs771032841,2
    C--40360784(+) ATCCCC/TATTTT 2 -- ds50010--------
    rs1826467851,2
    --40360792(+) TTTACC/TGATAA 2 -- ds50010--------
    rs1865770551,2
    --40360832(+) AAGGCG/TGCAGA 2 -- ds50010--------
    rs576101911,2
    C,F--40361151(+) TAAAAT/CCAGGC 2 -- ut314Minor allele frequency- C:0.03WA CSA 124
    rs603142581,2
    C--40361320(+) AAAGAC/TTCCCC 2 -- ut310--------
    rs31170841,2
    C--40361700(+) TGAGGT/ATACCC 2 -- ut31 ese33Minor allele frequency- A:0.05NA WA 240
    rs412975931,2
    C,F--40361783(-) CCCAGC/GTGGAC 2 -- ut316Minor allele frequency- G:0.26EU NA WA CSA 616

    HapMap Linkage Disequilibrium report for MYCL (40361096 - 40367928 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYCL: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MYCL
    DNA2.0 Custom Variant and Variant Library Synthesis for MYCL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164850    OMIM disorders: --

    Selected diseases for MYCL (see all 28):    About MalaCards
    lower lip cancer    lip cancer    lung cancer    merkel cell carcinoma
    lung cancer susceptibility    pleomorphic adenoma    neuroendocrine carcinoma    idiopathic pulmonary fibrosis
    soft tissue sarcoma    pulmonary fibrosis    oral cancer    thyroid cancer
    esophageal cancer    lung adenocarcinoma    non-hodgkin lymphoma    esophageal squamous cell carcinoma
    hodgkin's lymphoma    adenoma    myeloid leukemia    sarcoma


    MYCL for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MYCL gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic imbalance 59.5 3 11956626 (1), 12527710 (1), 12378519 (1)
    cancer lung 59.1 29 1975565 (3), 7908608 (3), 10717329 (3), 12169206 (2) (see all 16)
    small cell lung cancer 49.1 8 1331597 (2), 9747881 (1), 19020549 (1), 2171744 (1) (see all 6)
    hematopoietic malignancies 48 1 8260894 (1)
    tumors 35.8 32 12707044 (4), 10321885 (2), 2302711 (1), 2174659 (1) (see all 10)
    allelic loss 34.4 1 10717329 (1)
    lung carcinoma 33.8 1 1620120 (1)
    metastasis 33.1 12 1683040 (3), 1347036 (2), 1304834 (1), 12456990 (1) (see all 9)
    myeloid leukemia 31 1 1954386 (1)
    carcinoma squamous cell 30.5 3 12527710 (1), 1690210 (1), 1970484 (1)


    Export disorders for MYCL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYCL gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with MYCL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization. (PubMed id 8978772)1, 3 Speleman F....Van Roy N. (Cytogenet. Cell Genet. 1996)
    4. The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences. (PubMed id 2548855)1, 2 Ikegaki N.... Kennett R.H. (EMBO J. 1989)
    5. Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. (PubMed id 2827002)1, 2 Kaye F.... Minna J. (Mol. Cell. Biol. 1988)
    6. The human myc gene family: structure and activity of L-myc and an L- myc pseudogene. (PubMed id 3322939)1, 2 DePinho R.A.... Alt F.W. (Genes Dev. 1987)
    7. Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. (PubMed id 12707044)1, 9 Wu R....Cho K.R. (Am. J. Pathol. 2003)
    8. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. (PubMed id 19020549)1, 9 Paulson K.G....Nghiem P. (J. Invest. Dermatol. 2009)
    9. EcoRI polymorphism of the L-myc gene in gastric cancer patients. (PubMed id 12439118)1, 9 Dlugosz A....Starzynska T. (amp 2002)
    10. Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ. (PubMed id 11956626)1, 9 Primdahl H....A9rntoft T.F. (Oncol. Rep. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4610 HGNC: 7555 AceView: MYCL1 Ensembl:ENSG00000116990 euGenes: HUgn4610
    ECgene: MYCL H-InvDB: MYCL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYCL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYCL gene:
    Search GeneIP for patents involving MYCL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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