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Aliases for MYCBPAP Gene

Aliases for MYCBPAP Gene

  • MYCBP Associated Protein 2 3 5
  • AMY-1-Binding Protein 1 3 4
  • AMAM-1 3 4
  • AMAP-1 3 4
  • AMAP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 214e 3
  • AMY1-Associating Protein 1 3
  • MYCBP-Associated Protein 3

External Ids for MYCBPAP Gene

Previous GeneCards Identifiers for MYCBPAP Gene

  • GC17P049061
  • GC17P045940
  • GC17P048585
  • GC17P043953

Summaries for MYCBPAP Gene

GeneCards Summary for MYCBPAP Gene

MYCBPAP (MYCBP Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MYCBPAP Gene

  • May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBPAP Gene

Genomics for MYCBPAP Gene

Regulatory Elements for MYCBPAP Gene

Enhancers for MYCBPAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G050171 2.1 FANTOM5 Ensembl ENCODE dbSUPER 24.1 -315.9 -315863 42.0 CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 SGCA ENSG00000262837 CACNA1G-AS1 MYCBPAP LOC105371824 FLJ45513 NXPH3 TMEM92-AS1 COL1A1 TMEM92
GH17G050681 1.5 Ensembl ENCODE dbSUPER 25.4 +173.3 173271 1.1 HDGF PKNOX1 ZNF493 ZFP64 ARID4B SIN3A ZBTB7B ZNF207 ZNF143 ZNF263 ENSG00000262837 MYCBPAP LOC101927253 ABCC3 ANKRD40 SPATA20 LOC105371824 EPN3 COL1A1 KAT7
GH17G050532 1.6 Ensembl ENCODE dbSUPER 21.9 +25.6 25632 3.8 HDGF PKNOX1 AGO1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF143 FOS EPN3 SPATA20 CACNA1G-AS1 MYCBPAP CACNA1G LOC105371824
GH17G050507 1.3 Ensembl ENCODE 25.4 +1.6 1644 5.0 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZNF766 ZNF143 ZNF207 FOS MYCBPAP EPN3 RSAD1 ACSF2 LOC105371824 SPATA20 CACNA1G CACNA1G-AS1 CHAD ANKRD40
GH17G050907 1.6 Ensembl ENCODE dbSUPER 14.8 +401.6 401621 5.0 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS SP5 TOB1 MYCBPAP ENSG00000247011 ENSG00000251665 CACNA1G-AS1 ENSG00000262006 LOC105371825
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYCBPAP on UCSC Golden Path with GeneCards custom track

Promoters for MYCBPAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095678 16 801 ATF1 CREB3L1 SIN3A GLIS2 ZNF766 ELK1 ZNF143 ZNF207 KLF7 ZMIZ1

Genomic Location for MYCBPAP Gene

Chromosome:
17
Start:
50,508,384 bp from pter
End:
50,531,502 bp from pter
Size:
23,119 bases
Orientation:
Plus strand

Genomic View for MYCBPAP Gene

Genes around MYCBPAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBPAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBPAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBPAP Gene

Proteins for MYCBPAP Gene

  • Protein details for MYCBPAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ2-MYBPP_HUMAN
    Recommended name:
    MYCBP-associated protein
    Protein Accession:
    Q8TBZ2
    Secondary Accessions:
    • A6NHJ3
    • Q8TDV8
    • Q9H0K0

    Protein attributes for MYCBPAP Gene

    Size:
    947 amino acids
    Molecular mass:
    108153 Da
    Quaternary structure:
    • Interacts with MYCBP.

neXtProt entry for MYCBPAP Gene

Post-translational modifications for MYCBPAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYCBPAP Gene

Domains & Families for MYCBPAP Gene

Protein Domains for MYCBPAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYCBPAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYCBPAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYCBPAP Gene

Function for MYCBPAP Gene

Molecular function for MYCBPAP Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).

Gene Ontology (GO) - Molecular Function for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12151104
genes like me logo Genes that share ontologies with MYCBPAP: view
genes like me logo Genes that share phenotypes with MYCBPAP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYCBPAP Gene

Localization for MYCBPAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBPAP Gene

Cytoplasm. Membrane. Note=Colocalizes with MYCBP in the cytoplasm. {ECO:0000250 UniProtKB:Q69CM7, ECO:0000269 PubMed:12151104}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCBPAP gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12151104
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MYCBPAP: view

Pathways & Interactions for MYCBPAP Gene

SuperPathways for MYCBPAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 12151104
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYCBPAP: view

No data available for Pathways by source and SIGNOR curated interactions for MYCBPAP Gene

Drugs & Compounds for MYCBPAP Gene

No Compound Related Data Available

Transcripts for MYCBPAP Gene

Unigene Clusters for MYCBPAP Gene

MYCBP associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBPAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYCBPAP Gene

GeneLoc Exon Structure for
MYCBPAP
ECgene alternative splicing isoforms for
MYCBPAP

Expression for MYCBPAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYCBPAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCBPAP Gene

This gene is overexpressed in Testis (x33.2).

Protein differential expression in normal tissues from HIPED for MYCBPAP Gene

This gene is overexpressed in Stomach (28.8), Esophagus (14.5), Breast (12.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYCBPAP Gene



NURSA nuclear receptor signaling pathways regulating expression of MYCBPAP Gene:

MYCBPAP

SOURCE GeneReport for Unigene cluster for MYCBPAP Gene:

Hs.398196

mRNA Expression by UniProt/SwissProt for MYCBPAP Gene:

Q8TBZ2-MYBPP_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with MYCBPAP: view

Primer Products

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCBPAP Gene

Orthologs for MYCBPAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBPAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCBPAP 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia MYCBPAP 34 35
  • 84.36 (n)
dog
(Canis familiaris)
Mammalia MYCBPAP 34 35
  • 83.3 (n)
mouse
(Mus musculus)
Mammalia Mycbpap 34 16 35
  • 77.31 (n)
rat
(Rattus norvegicus)
Mammalia Mycbpap 34
  • 75.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MYCBPAP 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCBPAP 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYCBPAP 34 35
  • 56.18 (n)
lizard
(Anolis carolinensis)
Reptilia MYCBPAP 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbpap 34
  • 54.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882572 34
  • 51.49 (n)
mycbpap 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
Species where no ortholog for MYCBPAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBPAP Gene

ENSEMBL:
Gene Tree for MYCBPAP (if available)
TreeFam:
Gene Tree for MYCBPAP (if available)

Paralogs for MYCBPAP Gene

genes like me logo Genes that share paralogs with MYCBPAP: view

No data available for Paralogs for MYCBPAP Gene

Variants for MYCBPAP Gene

Sequence variations from dbSNP and Humsavar for MYCBPAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000079395 -- 50,521,814(+) AGCAA(C/T)GGGTC intron-variant
rs1000169888 -- 50,507,073(+) GTGCA(A/G)TCAGA upstream-variant-2KB
rs1000289527 -- 50,523,488(+) GATGG(C/T)TGGCC intron-variant
rs1000390833 -- 50,512,141(+) CTCTG(C/G)CTCCC intron-variant
rs1000626905 -- 50,522,101(+) ACCAC(A/G)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYCBPAP Gene

Variant ID Type Subtype PubMed ID
nsv111976 CNV deletion 16902084
nsv2082 CNV insertion 18451855
nsv833477 CNV loss 17160897

Variation tolerance for MYCBPAP Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCBPAP Gene

Human Gene Mutation Database (HGMD)
MYCBPAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYCBPAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCBPAP Gene

Disorders for MYCBPAP Gene

Relevant External Links for MYCBPAP

Genetic Association Database (GAD)
MYCBPAP
Human Genome Epidemiology (HuGE) Navigator
MYCBPAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCBPAP

No disorders were found for MYCBPAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBPAP Gene

Publications for MYCBPAP Gene

  1. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H. … Ariga H. (Biochim. Biophys. Acta 2002) 2 3 4 22 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
  5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A. … Oetting W.S. (Transplantation 2010) 46 64

Products for MYCBPAP Gene

Sources for MYCBPAP Gene

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