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Aliases for MYCBPAP Gene

Aliases for MYCBPAP Gene

  • MYCBP Associated Protein 2 3 5
  • AMY-1-Binding Protein 1 3 4
  • AMAM-1 3 4
  • AMAP-1 3 4
  • AMAP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 214e 3
  • AMY1-Associating Protein 1 3

External Ids for MYCBPAP Gene

Previous GeneCards Identifiers for MYCBPAP Gene

  • GC17P049061
  • GC17P045940
  • GC17P048585
  • GC17P043953

Summaries for MYCBPAP Gene

GeneCards Summary for MYCBPAP Gene

MYCBPAP (MYCBP Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MYCBPAP Gene

  • May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBPAP Gene

Genomics for MYCBPAP Gene

Regulatory Elements for MYCBPAP Gene

Promoters for MYCBPAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYCBPAP on UCSC Golden Path with GeneCards custom track

Genomic Location for MYCBPAP Gene

Chromosome:
17
Start:
50,508,384 bp from pter
End:
50,531,502 bp from pter
Size:
23,119 bases
Orientation:
Plus strand

Genomic View for MYCBPAP Gene

Genes around MYCBPAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBPAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBPAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBPAP Gene

Proteins for MYCBPAP Gene

  • Protein details for MYCBPAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ2-MYBPP_HUMAN
    Recommended name:
    MYCBP-associated protein
    Protein Accession:
    Q8TBZ2
    Secondary Accessions:
    • A6NHJ3
    • Q8TDV8
    • Q9H0K0

    Protein attributes for MYCBPAP Gene

    Size:
    947 amino acids
    Molecular mass:
    108153 Da
    Quaternary structure:
    • Interacts with MYCBP.

neXtProt entry for MYCBPAP Gene

Proteomics data for MYCBPAP Gene at MOPED

Post-translational modifications for MYCBPAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYCBPAP Gene

Domains & Families for MYCBPAP Gene

Protein Domains for MYCBPAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYCBPAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYCBPAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYCBPAP Gene

Function for MYCBPAP Gene

Molecular function for MYCBPAP Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).
genes like me logo Genes that share phenotypes with MYCBPAP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYCBPAP Gene

Localization for MYCBPAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBPAP Gene

Cytoplasm. Membrane. Note=Colocalizes with MYCBP in the cytoplasm. {ECO:0000250 UniProtKB:Q69CM7, ECO:0000269 PubMed:12151104}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCBPAP Gene COMPARTMENTS Subcellular localization image for MYCBPAP gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MYCBPAP Gene

Pathways & Interactions for MYCBPAP Gene

SuperPathways for MYCBPAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 12151104
genes like me logo Genes that share ontologies with MYCBPAP: view

No data available for Pathways by source and SIGNOR curated interactions for MYCBPAP Gene

Drugs & Compounds for MYCBPAP Gene

No Compound Related Data Available

Transcripts for MYCBPAP Gene

Unigene Clusters for MYCBPAP Gene

MYCBP associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBPAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYCBPAP Gene

GeneLoc Exon Structure for
MYCBPAP
ECgene alternative splicing isoforms for
MYCBPAP

Expression for MYCBPAP Gene

mRNA expression in normal human tissues for MYCBPAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCBPAP Gene

This gene is overexpressed in Testis (x33.2).

Protein differential expression in normal tissues from HIPED for MYCBPAP Gene

This gene is overexpressed in Stomach (28.8), Esophagus (14.5), Breast (12.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYCBPAP Gene



SOURCE GeneReport for Unigene cluster for MYCBPAP Gene Hs.398196

mRNA Expression by UniProt/SwissProt for MYCBPAP Gene

Q8TBZ2-MYBPP_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with MYCBPAP: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MYCBPAP Gene

Orthologs for MYCBPAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBPAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYCBPAP 35
  • 84.36 (n)
  • 76.86 (a)
MYCBPAP 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYCBPAP 35
  • 83.3 (n)
  • 76.17 (a)
MYCBPAP 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycbpap 35
  • 77.31 (n)
  • 71.57 (a)
Mycbpap 16
Mycbpap 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYCBPAP 35
  • 99.61 (n)
  • 99.16 (a)
MYCBPAP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycbpap 35
  • 75.56 (n)
  • 70.82 (a)
oppossum
(Monodelphis domestica)
Mammalia MYCBPAP 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCBPAP 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYCBPAP 35
  • 56.18 (n)
  • 48.15 (a)
MYCBPAP 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCBPAP 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbpap 35
  • 54.73 (n)
  • 45.25 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882572 35
  • 51.49 (n)
  • 38.71 (a)
mycbpap 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
Species with no ortholog for MYCBPAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBPAP Gene

ENSEMBL:
Gene Tree for MYCBPAP (if available)
TreeFam:
Gene Tree for MYCBPAP (if available)

Paralogs for MYCBPAP Gene

genes like me logo Genes that share paralogs with MYCBPAP: view

No data available for Paralogs for MYCBPAP Gene

Variants for MYCBPAP Gene

Sequence variations from dbSNP and Humsavar for MYCBPAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1380657 - 50,521,424(+) ACACA(A/G)CATAC nc-transcript-variant, reference, missense
rs9890721 - 50,526,142(+) CTCAG(C/T)GGAAG nc-transcript-variant, reference, missense
rs1133818 - 50,529,176(+) CAGAG(C/G)CTGCA nc-transcript-variant, reference, missense
rs1460213 -- 50,520,814(+) ATGAA(A/G)TGTAT intron-variant
rs1460214 -- 50,520,918(+) ATTTT(G/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYCBPAP Gene

Variant ID Type Subtype PubMed ID
dgv3228n71 CNV Gain 21882294
nsv908600 CNV Gain 21882294
dgv3229n71 CNV Loss 21882294
nsv2082 CNV Insertion 18451855
nsv833477 CNV Loss 17160897
dgv3230n71 CNV Loss 21882294
nsv111976 CNV Loss 16902084

Variation tolerance for MYCBPAP Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCBPAP Gene

HapMap Linkage Disequilibrium report
MYCBPAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCBPAP Gene

Disorders for MYCBPAP Gene

Relevant External Links for MYCBPAP

Genetic Association Database (GAD)
MYCBPAP
Human Genome Epidemiology (HuGE) Navigator
MYCBPAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCBPAP

No disorders were found for MYCBPAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBPAP Gene

Publications for MYCBPAP Gene

  1. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H. … Ariga H. (Biochim. Biophys. Acta 2002) 2 3 4 23 67
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. (PMID: 18843202) Miyata M. … Sabe H. (Cell Cycle 2008) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for MYCBPAP Gene

Sources for MYCBPAP Gene

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