Aliases for MYCBP2 Gene
Aliases for MYCBP2 Gene
External Ids for MYCBP2 Gene
- HGNC: 23386
- Entrez Gene: 23077
- Ensembl: ENSG00000005810
- OMIM: 610392
- UniProtKB: O75592
Previous GeneCards Identifiers for MYCBP2 Gene
- GC13M075417
- GC13M076517
- GC13M077618
- GC13M058316
Summaries for MYCBP2 Gene
-
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
GeneCards Summary for MYCBP2 Gene
MYCBP2 (MYC Binding Protein 2, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with MYCBP2 include Ecthyma and Reticulate Acropigmentation Of Kitamura. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include protein homodimerization activity and ligase activity.
UniProtKB/Swiss-Prot for MYCBP2 Gene
-
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBP2 Gene
Genomics for MYCBP2 Gene
Regulatory Elements for MYCBP2 Gene
Enhancers for MYCBP2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13G077429 | 1.2 | FANTOM5 ENCODE | 12.7 | -102.8 | -102842 | 1.6 | TBP PKNOX1 BMI1 CBX5 ZNF143 ZNF207 RELB ETV6 IKZF2 CREM | MYCBP2 LOC105370271 |
| GH13G077299 | 1.1 | Ensembl ENCODE dbSUPER | 13.8 | +26.5 | 26488 | 1.7 | ZNF316 GATA2 BHLHE40 CEBPB FOS MAFK SPI1 | MYCBP2 CLN5 GC13P077273 |
| GH13G077477 | 1.2 | Ensembl ENCODE | 12.1 | -151.3 | -151280 | 1.6 | HDGF PKNOX1 ATF1 ZNF2 YY1 GTF3C2 ZNF143 ZNF207 JUNB REST | MYCBP2 LOC105370271 SCEL |
| GH13G077297 | 0.9 | Ensembl ENCODE dbSUPER | 13.3 | +28.7 | 28708 | 1.6 | IKZF2 SPI1 | MYCBP2 CLN5 MYCBP2-AS1 GC13P077273 |
| GH13G077324 | 1.7 | FANTOM5 ENCODE dbSUPER | 6.4 | +0.7 | 746 | 3.1 | HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 | MYCBP2 CLN5 FBXL3 KCTD12 GC13P077273 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MYCBP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MYCBP2 gene promoter:
Regulatory Element Products
Genomic Location for MYCBP2 Gene
- Chromosome:
- 13
- Start:
- 77,044,655 bp from pter
- End:
- 77,327,050 bp from pter
- Size:
- 282,396 bases
- Orientation:
- Minus strand
Genomic View for MYCBP2 Gene
Genes around MYCBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q22.3 by Ensembl
- 13q22.3 by Entrez Gene
- 13q22.3 by HGNC
MYCBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYCBP2 Gene
Proteins for MYCBP2 Gene
-
Protein details for MYCBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75592-MYCB2_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase MYCBP2
- Protein Accession:
- O75592
- A6NJC6
- Q5JSX8
- Q5VZN6
- Q6PIB6
- Q9UQ11
- Q9Y6E4
Protein attributes for MYCBP2 Gene
- Size:
- 4640 amino acids
- Molecular mass:
- 510084 Da
- Quaternary structure:
-
- Interacts with MYC (PubMed:9689053). Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) (PubMed:14559897). Interacts with FBXO45 (PubMed:19398581). Interacts with RAE1 (PubMed:22357847). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity).
- SequenceCaution:
-
- Sequence=AAD39842.1; Type=Frameshift; Positions=4636; Evidence={ECO:0000305}; Sequence=AAH37971.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39758.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for MYCBP2 Gene
Post-translational modifications for MYCBP2 Gene
- Autoubiquitinated.
- Ubiquitination at posLast=10081008, posLast=20942094, and posLast=37503750
- Modification sites at PhosphoSitePlus
Other Protein References for MYCBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_055872.4
- XP_005266356.1
- XP_006719842.1
- XP_006719843.1
- XP_006719844.1
- XP_006719845.1
- XP_006719846.1
- XP_006719847.1
- XP_006719848.1
- XP_006719849.1
- XP_006719850.1
- XP_006719851.1
- XP_006719852.1
- XP_011533306.1
- XP_011533307.1
- XP_016875943.1
- XP_016875944.1
- XP_016875945.1
- XP_016875946.1
- XP_016875947.1
- XP_016875948.1
- XP_016875949.1
- XP_016875950.1
- XP_016875951.1
- XP_016875952.1
- XP_016875953.1
- XP_016875954.1
- XP_016875955.1
- XP_016875956.1
- XP_016875957.1
Antibody Products
- Novus Biologicals Antibodies for MYCBP2
-
Abcam antibodies for MYCBP2
- antibodies-online Antibodies for MYCBP2: See all 13
- Search GeneTex for Antibodies for MYCBP2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYCBP2
- Origene Custom Protein Services for MYCBP2
- Search GeneTex for Proteins for MYCBP2
No data available for DME Specific Peptides for MYCBP2 Gene
Domains & Families for MYCBP2 Gene
Protein Domains for MYCBP2 Gene
Suggested Antigen Peptide Sequences for MYCBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75592UniProtKB/Swiss-Prot:
MYCB2_HUMAN :- The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
- Belongs to the highwire family.
- Domain:
-
- The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
- Family:
-
- Belongs to the highwire family.
No data available for Gene Families for MYCBP2 Gene
Function for MYCBP2 Gene
Molecular function for MYCBP2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.
Enzyme Numbers (IUBMB) for MYCBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for MYCBP2 Gene
- MGI mutant phenotypes for MYCBP2:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for MYCBP2:
Animal Models for MYCBP2 Gene
- MGI Knock Outs for MYCBP2:
-
- Mycbp2 tm1.1Adia
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYCBP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MYCBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYCBP2 gene
- Search ViGene Biosciences for MYCBP2
CRISPR Products
-
OriGene CRISPR knockouts for MYCBP2
-
Applied Biological Materials CRISPR for MYCBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYCBP2
miRNA for MYCBP2 Gene
- miRTarBase miRNAs that target MYCBP2
-
- hsa-mir-21-5p (MIRT030878)
- hsa-mir-15b-5p (MIRT046460)
- hsa-mir-183-5p (MIRT047123)
- hsa-mir-148a-3p (MIRT048035)
- hsa-mir-196a-5p (MIRT048178)
- hsa-mir-17-5p (MIRT050846)
- hsa-mir-377-3p (MIRT440167)
- hsa-mir-487a-3p (MIRT440168)
- hsa-mir-493-3p (MIRT440169)
- hsa-mir-6083 (MIRT721107)
- hsa-mir-4795-3p (MIRT721108)
- hsa-mir-496 (MIRT721109)
- hsa-mir-4742-3p (MIRT721110)
- hsa-mir-126-5p (MIRT721111)
- hsa-mir-606 (MIRT721112)
miRNA Products
- Search ViGene Biosciences for MYCBP2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MYCBP2
- Browse OriGene Inhibitory RNA Products For MYCBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for MYCBP2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MYCBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYCBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MYCBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for MYCBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MYCBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYCBP2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYCBP2 Gene
Localization for MYCBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYCBP2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for MYCBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrated Breast Cancer Pathway | ||
Pathways by source for MYCBP2 Gene
1 BioSystems pathway for MYCBP2 Gene
UniProtKB/Swiss-Prot O75592-MYCB2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for MYCBP2 Gene
Drugs & Compounds for MYCBP2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for MYCBP2 Gene
mRNA/cDNA for MYCBP2 Gene
- (30) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (270) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MYCBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MYCBP2
-
Applied Biological Materials CRISPR for MYCBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYCBP2
miRNA Products
- Search ViGene Biosciences for MYCBP2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MYCBP2
- Browse OriGene Inhibitory RNA Products For MYCBP2
-
ViGene Biosciences ready-to-package AAV shRNAs for MYCBP2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MYCBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYCBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: |
Expression for MYCBP2 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (35.4) and Testis (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYCBP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MYCBP2 Gene:
MYCBP2SOURCE GeneReport for Unigene cluster for MYCBP2 Gene:
Hs.591221mRNA Expression by UniProt/SwissProt for MYCBP2 Gene:
O75592-MYCB2_HUMAN
Tissue specificity:
Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.
Evidence on tissue expression from TISSUES for MYCBP2 Gene
- Nervous system(4.7)
- Liver(4.4)
- Lung(2.1)
- Heart(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for MYCBP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCBP2 Gene
Orthologs for MYCBP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | MYCBP2 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MYCBP2 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MYCBP2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MYCBP2 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mycbp2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mycbp2 34 |
|
||
| chicken (Gallus gallus) |
Aves | MYCBP2 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MYCBP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.3526 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mycbp2 34 35 |
|
||
| Dr.17163 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12300 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | hiw 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011177 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rpm-1 35 34 |
|
OneToMany | |
| F07B7.12 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4977 34 |
|
- Species where no ortholog for MYCBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MYCBP2 Gene
(3) SIMAP similar genes for MYCBP2 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for MYCBP2 Gene
No data available for Paralogs for MYCBP2 Gene
Variants for MYCBP2 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920951 | Uncertain significance | 77,126,432(-) | GGCAT(A/C/G)TACAA | intron-variant, reference, missense | |
| rs386352333 | Uncertain significance | 77,051,078(-) | GAACA(A/G)CACAT | reference, missense | |
| rs1000003742 | -- | 77,199,934(+) | ACAAA(C/G)ATGGG | intron-variant | |
| rs1000004973 | -- | 77,201,890(+) | TTCAA(A/C)GCAGT | intron-variant | |
| rs1000009677 | -- | 77,288,743(+) | GTCTC(A/C)ATGAC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1226195 | CNV | insertion | 17803354 |
| esv2515250 | CNV | insertion | 19546169 |
| esv2759951 | CNV | loss | 17122850 |
| esv3550737 | CNV | deletion | 23714750 |
| nsv1037653 | CNV | loss | 25217958 |
| nsv1039620 | CNV | gain | 25217958 |
| nsv1148797 | CNV | duplication | 26484159 |
| nsv528143 | CNV | loss | 19592680 |
| nsv832653 | CNV | loss | 17160897 |
Gene Damage Index Score:
4.67;
65.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MYCBP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCBP2 Gene
Disorders for MYCBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ecthyma |
|
|
| reticulate acropigmentation of kitamura |
|
|
| brunner syndrome |
|
|
Search MYCBP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MYCBP2
No data available for UniProtKB/Swiss-Prot and Genatlas for MYCBP2 Gene
Publications for MYCBP2 Gene
- The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4 64
- Identification of a large Myc-binding protein that contains RCC1-like repeats. (PMID: 9689053) Guo Q. … Bishop J.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
- RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. (PMID: 22357847) Grill B. … Garner C.C. (J. Neurosci. 2012) 3 4 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. (PMID: 19398581) Saiga T. … Nakayama K.I. (Mol. Cell. Biol. 2009) 3 4 64
Products for MYCBP2 Gene
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MYCBP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MYCBP2
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Search GeneTex for Antibodies for MYCBP2
- Search GeneTex for Proteins for MYCBP2
- ViGene Biosciences adenoviral particle packaged cDNA for MYCBP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MYCBP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MYCBP2 gene
- Search ViGene Biosciences for MYCBP2
- Horizon Cell Lines for MYCBP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYCBP2
- VectorBuilder custom plasmid, inducible vectors for MYCBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYCBP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MYCBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio