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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYCBP Gene

protein-coding   GIFtS: 55
GCID: GC01M039328

c-myc binding protein
 Explore 1 disease affiliated with
MYCBP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYCBP    

Aliases
for MYCBP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
C-Myc Binding Protein1 2
AMY-11 2 3
Associate Of Myc-12
C-Myc-Binding Protein2
AMY13
Associate Of Myc 13

External Ids:    HGNC: 75541   Entrez Gene: 262922   Ensembl: ENSG000002141147   OMIM: 6065355   UniProtKB: Q994173   
ORGUL members:         
NONCODE:n410492 n410491 n410490 n410493    

Export aliases for MYCBP gene to outside databases

Previous GC identifers: GC01M039252 GC01M038336 GC01M038792 GC01M038741 GC01M038997 GC01M039101 GC01M037446


Summaries
for MYCBP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYCBP:
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC
to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates
to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in
spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other
probably not protein-coding, have been found for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
Function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription
by MYC

Gene Wiki entry for MYCBP


Genomic Views
for MYCBP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYCBP gene promoter:
         SRF   SRF (504 AA)   AP-2gamma   NF-AT   C/EBPalpha   HFH-1   AP-2beta   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYCBP promoter sequence
   Search SABiosciences Chromatin IP Primers for MYCBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32.2   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p33-p32.2

MYCBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYCBP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M039328:  view genomic region     (about GC identifiers)

Start:
 39,328,636 bp from pter      End:
 39,347,289 bp from pter
Size:
 18,654 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n410493
  • n410490
  • n410491
  • n410492
39328161 39337730 39347298 chr1

Proteins
for MYCBP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417 (See protein sequence)
Recommended Name: C-Myc-binding protein  
Size: 103 amino acids; 11967 Da
Subunit: Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts
with MYCBPAP
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell
cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1
1 PDB 3D structure from and Proteopedia for MYCBP:
2YY0 (3D)    
Secondary accessions: B2R4N0 Q5TA64 Q96HE2

Explore the universe of human proteins at neXtProt for MYCBP: NX_Q99417

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99417

    • MYCBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036465.2  
    ENSEMBL proteins: 
     ENSP00000380702  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MYCBP
    OriGene Protein Over-expression Lysate: MYCBP
    OriGene Custom Protein Services for MYCBP 
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    Novus Biologicals MYCBP Proteins
    Novus Biologicals MYCBP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MYCBP
    Uscn Proteins for MYCBP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9797456
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IDA--


    MYCBP for ontologies           About GeneDecksing



    MYCBP Antibody Products: 
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    Uscn Antibodies for MYCBP
    Search ThermoFisher Antibodies for MYCBP

    Assay Products for MYCBP: 
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    Uscn ELISAs and CLIAs for MYCBP

    Protein Domains /
    Families
    for MYCBP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYCBP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026060 AMY1

    Graphical View of Domain Structure for InterPro Entry Q99417

    ProtoNet protein and cluster: Q99417

    UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
    Similarity: Belongs to the AMY1 family


    Function
    for MYCBP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
    Function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription
    by MYC

         Genatlas biochemistry entry for MYCBP:
    c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC)
    expression,stimulating the activation of the E-box regulated transcription by MYC/MAX

    miRNA
    Products:            		miRTarBase miRNAs that target MYCBP:
    hsa-mir-22 (MIRT005505)

    OriGene 3'-UTR Clone: MYCBP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYCBP
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate MYCBP (see all 88):
    hsa-miR-579 hsa-miR-520f hsa-miR-361-5p hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-759 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: MYCBP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYCBP (see all 4)
    OriGene shRNA RFP: MYCBP
    OriGene siRNA: MYCBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYCBP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYCBP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYCBP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYCBP
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    GenScript: all cDNA clones in your preferred vector: MYCBP (NM_015057)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCBP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MYCBP
    Search LifeMap BioReagents cell lines for MYCBP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCBP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA9797456
    GO:0005515protein binding IPI16866877


    MYCBP for ontologies           About GeneDecksing



    Pathways & Interactions
    for MYCBP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Notch signaling pathway
    		Notch signaling pathway1.00


    1 BioSystems Pathway for MYCBP 
        Notch signaling pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYCBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/73 Interacting proteins for MYCBP (Q994171, 2, 3 ENSP000003807024) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF40Q8TER52, 3, ENSP000002986944MINT-65269 I2D: score=5 STRING: ENSP00000298694
    PTCHD2Q9P2K92, 3, ENSP000002944844MINT-65267 I2D: score=5 STRING: ENSP00000294484
    CFL1P235282, 3MINT-65265 I2D: score=5 
    GDF9O603832, 3MINT-65263 I2D: score=5 
    PTNP212462, 3MINT-65264 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA9797456
    GO:0007283spermatogenesis IEP12151104


    MYCBP for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYCBP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYCBP
    Search CenterWatch for drugs/clinical trials and news about MYCBP 

    Transcripts
    for MYCBP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYCBP gene: 
    NM_012333.4  

    Unigene Cluster for MYCBP:

    C-myc binding protein
    Hs.591506  [show with all ESTs]
    Unigene Representative Sequence: NR_037633
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397572(uc001ccs.3 uc021olq.1) ENST00000494695 ENST00000495043
    ENST00000489803 ENST00000489575 ENST00000465771 ENST00000462027

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MYCBP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYCBP
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate MYCBP (see all 88):
    hsa-miR-579 hsa-miR-520f hsa-miR-361-5p hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-759 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: MYCBP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYCBP (see all 4)
    OriGene shRNA RFP: MYCBP
    OriGene siRNA: MYCBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYCBP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYCBP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYCBP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYCBP (NM_015057)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYCBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYCBP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYCBP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYCBP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYCBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYCBP

    Additional cDNA sequence: 

    AB007191.2 AB451287.1 AB451419.1 AF271261.1 AK095035.1 AK311886.1 AK312811.1 BC008686.1 
    BT007109.1 CR456936.1 D50692.1 NR_037632.1 NR_037633.1 NR_037634.1 NR_037635.1 NR_037636.1 
    NR_037637.1 

    15 DOTS entries:

    DT.445919  DT.100794114  DT.95309954  DT.97845735  DT.100794113  DT.95076061  DT.121348351  DT.95076062 
    DT.97811754  DT.101975994  DT.75138988  DT.75172997  DT.121348334  DT.95076077  DT.95308659 

    24/538 AceView cDNA sequences (see all 538):

    AY126343 AA495781 BI771507 R35407 BU947961 BU579993 AW302161 AI765647 
    AA904343 CB159363 CR595258 AA352872 AI418896 AA581659 AI419602 BU947399 
    CD672478 BU732697 BI770903 N42625 AF272035 R35574 BE467375 AW327608 

    GeneLoc Exon Structure


    Expression
    for MYCBP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYCBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCCGTGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYCBP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MYCBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYCBP

    SOURCE GeneReport for Unigene cluster: Hs.591506

    UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
    Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low
    levels in lung

        SABiosciences Custom PCR Arrays for MYCBP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYCBP

    Orthologs
    for MYCBP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYCBP gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mycbp1 , 5 c-myc binding protein1, 5 95.15(n)1
    97.09(a)1    		   4 (57.42 cM)5
    563091  NM_019660.31  NP_062634.21 
     1239048325 
    chicken
    (Gallus gallus)    		 Aves MYCBP1 c-myc binding protein 81.55(n)
    87.38(a)    		   770496  XM_001232873.2  XP_001232874.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MYCBP6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343426.1(761134-762000)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.64912 Xenopus laevis transcribed sequence with moderate similarity more 74.85(n)    AW633953.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AL908806.12   -- 76.73(n)    AL908806.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 45(a)
    		 1 ↔ 1
    		 Group1.51(1053572-1054131)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G140456
    		 uncharacterized protein
    		 30(a)
    		 1 ↔ 1
    		 2(5906550-5908374)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 C-Myc-binding protein, putative, expressed
    		 40(a)
    		 1 ↔ 1
    		 7(4556243-4558679)


    ENSEMBL Gene Tree for MYCBP (if available)
    TreeFam Gene Tree for MYCBP (if available) 

    Paralogs
    for MYCBP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYCBP gene

    MYCBP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MYCBP
    PGOHUM00000249168 PGOHUM00000240024


    Genomic Variants
    for MYCBP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 NCBI SNPs in MYCBP are shown (see all 219)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1493051481,2
    		--39327671(+) TTTAA-/CCTGCC 7 -- ds50010--------
    rs1877770571,2
    		--39327841(+) CACCTA/GGACAG 7 -- ds50010--------
    rs746327291,2
    		C,--39327980(+) AACCTA/GAATGT 7 -- ds50012Minor allele frequency- G:0.13WA 120
    rs759943741,2
    		F,--39328026(+) GCAGTT/ATGGGT 7 -- ds50011Minor allele frequency- A:0.09WA 118
    rs19844821,2
    		C,F,H,--39328164(-) TAAAAG/TTGCCT 7 -- nc-transcript-variantut318Minor allele frequency- T:0.02MN NS EA NA WA 1010
    rs343933481,2
    		C,F,H,--39328203(+) AACCAA/CCTTGT 7 -- nc-transcript-variantut3121Minor allele frequency- C:0.38NS EA NA WA 2346
    rs1914817651,2
    		--39328328(+) ATTCAC/TCCAAA 7 -- nc-transcript-variantut310--------
    rs1176475421,2
    		F,--39328586(+) TTCAAC/TCTGTA 7 -- nc-transcript-variantut311Minor allele frequency- T:0.04EA 120
    rs774501611,2
    		C,F,--39328704(+) CACTGT/CANNNN 7 -- nc-transcript-variantut311Minor allele frequency- C:0.02NA 120
    rs1842503351,2
    		--39328835(+) TCTGGA/GCCCCC 7 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for MYCBP (39328636 - 39347289 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MYCBP
         2 CNVs: 74452 84182

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYCBP
    DNA2.0 Custom Variant and Variant Library Synthesis for MYCBP

    Disorders / Diseases
    for MYCBP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYCBP for disorders           About GeneDecksing

    OMIM gene information: 606535    OMIM disorders: --

    1 disease for MYCBP:    About MalaCards
    gastric cancer

    Human Genome Epidemiology (HuGE) Navigator: MYCBP (1 document)

    Export disorders for MYCBP gene to outside databases

    Publications
    for MYCBP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYCBP gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MYCBP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PubMed id 9797456)1, 2, 3, 9 Taira T.... Ariga H. (1998)
    2. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PubMed id 11483602)1, 2, 9 Furusawa M.... Ariga H. (2001)
    3. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PubMed id 12151104)1, 2, 9 Yukitake H.... Ariga H. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PubMed id 12223483)1, 9 Yukitake H.... Ariga H. (2002)
    7. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. (PubMed id 12414807)1, 9 Furusawa M....Ariga H. (2002)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for MYCBP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MYCBP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26292 HGNC: 7554 AceView: MYCBPandRHBDL2andRRAGCandGJA10 Ensembl:ENSG00000214114 euGenes: HUgn26292
    ECgene: MYCBP H-InvDB: MYCBP

    Other Databases showing MYCBP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYCBP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYCBP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYCBP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MYCBP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYCBP gene:
    Search GeneIP for patents involving MYCBP

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