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Aliases for MYCBP Gene

Aliases for MYCBP Gene

  • MYC Binding Protein 2 3 5
  • C-Myc Binding Protein 2 3
  • Associate Of Myc-1 2 3
  • AMY-1 3 4
  • Associate Of Myc 1 4
  • AMY1 4

External Ids for MYCBP Gene

Previous GeneCards Identifiers for MYCBP Gene

  • GC01M039252
  • GC01M038336
  • GC01M038792
  • GC01M038741
  • GC01M038997
  • GC01M039101
  • GC01M039328
  • GC01M037446

Summaries for MYCBP Gene

Entrez Gene Summary for MYCBP Gene

  • The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MYCBP Gene

MYCBP (MYC Binding Protein) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (Pathway Interaction Database). GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000274944.

UniProtKB/Swiss-Prot for MYCBP Gene

  • May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

Gene Wiki entry for MYCBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBP Gene

Genomics for MYCBP Gene

Regulatory Elements for MYCBP Gene

Promoters for MYCBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYCBP on UCSC Golden Path with GeneCards custom track

Genomic Location for MYCBP Gene

Chromosome:
1
Start:
38,862,490 bp from pter
End:
38,874,105 bp from pter
Size:
11,616 bases
Orientation:
Minus strand

Genomic View for MYCBP Gene

Genes around MYCBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBP Gene

Proteins for MYCBP Gene

  • Protein details for MYCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99417-MYCBP_HUMAN
    Recommended name:
    C-Myc-binding protein
    Protein Accession:
    Q99417
    Secondary Accessions:
    • B2R4N0
    • Q5TA64
    • Q96HE2

    Protein attributes for MYCBP Gene

    Size:
    103 amino acids
    Molecular mass:
    11967 Da
    Quaternary structure:
    • Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.

    Three dimensional structures from OCA and Proteopedia for MYCBP Gene

neXtProt entry for MYCBP Gene

Proteomics data for MYCBP Gene at MOPED

Post-translational modifications for MYCBP Gene

  • Ubiquitination at Lys 5 and Lys 20
  • Modification sites at PhosphoSitePlus

Other Protein References for MYCBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MYCBP

No data available for DME Specific Peptides for MYCBP Gene

Domains & Families for MYCBP Gene

Protein Domains for MYCBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYCBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99417

UniProtKB/Swiss-Prot:

MYCBP_HUMAN :
  • Belongs to the AMY1 family.
Family:
  • Belongs to the AMY1 family.
genes like me logo Genes that share domains with MYCBP: view

No data available for Gene Families for MYCBP Gene

Function for MYCBP Gene

Molecular function for MYCBP Gene

GENATLAS Biochemistry:
c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC) expression,stimulating the activation of the E-box regulated transcription by MYC/MAX
UniProtKB/Swiss-Prot Function:
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
genes like me logo Genes that share phenotypes with MYCBP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MYCBP

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYCBP Gene

Localization for MYCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBP Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCBP Gene COMPARTMENTS Subcellular localization image for MYCBP gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9797456
genes like me logo Genes that share ontologies with MYCBP: view

Pathways & Interactions for MYCBP Gene

genes like me logo Genes that share pathways with MYCBP: view

Pathways by source for MYCBP Gene

1 BioSystems pathway for MYCBP Gene

Gene Ontology (GO) - Biological Process for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEP 12151104
genes like me logo Genes that share ontologies with MYCBP: view

No data available for SIGNOR curated interactions for MYCBP Gene

Drugs & Compounds for MYCBP Gene

No Compound Related Data Available

Transcripts for MYCBP Gene

Unigene Clusters for MYCBP Gene

C-myc binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBP Gene

No ASD Table

Relevant External Links for MYCBP Gene

GeneLoc Exon Structure for
MYCBP
ECgene alternative splicing isoforms for
MYCBP

Expression for MYCBP Gene

mRNA expression in normal human tissues for MYCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYCBP Gene

This gene is overexpressed in Lavage (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYCBP Gene



SOURCE GeneReport for Unigene cluster for MYCBP Gene Hs.591506

mRNA Expression by UniProt/SwissProt for MYCBP Gene

Q99417-MYCBP_HUMAN
Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
genes like me logo Genes that share expression patterns with MYCBP: view

Protein tissue co-expression partners for MYCBP Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MYCBP Gene

Orthologs for MYCBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCBP 36
  • 100 (a)
OneToOne
MYCBP 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MYCBP 36
  • 99 (a)
OneToOne
MYCBP 35
  • 97.09 (n)
  • 99.03 (a)
dog
(Canis familiaris)
Mammalia MYCBP 35
  • 96.76 (n)
  • 99.03 (a)
MYCBP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycbp 36
  • 97 (a)
OneToOne
Mycbp 16
Mycbp 35
  • 95.15 (n)
  • 97.09 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MYCBP 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycbp 35
  • 94.17 (n)
  • 97.09 (a)
chicken
(Gallus gallus)
Aves MYCBP 36
  • 81 (a)
OneToOne
MYCBP 35
  • 81.55 (n)
  • 87.38 (a)
lizard
(Anolis carolinensis)
Reptilia MYCBP 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6491 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbp 35
  • 72.49 (n)
  • 78.64 (a)
Str.10099 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4055 35
zebrafish
(Danio rerio)
Actinopterygii mycbp 36
  • 53 (a)
OneToOne
mycbp 35
  • 61.76 (n)
  • 63.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4517 35
Species with no ortholog for MYCBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBP Gene

ENSEMBL:
Gene Tree for MYCBP (if available)
TreeFam:
Gene Tree for MYCBP (if available)

Paralogs for MYCBP Gene

Paralogs for MYCBP Gene

Pseudogenes.org Pseudogenes for MYCBP Gene

genes like me logo Genes that share paralogs with MYCBP: view

Variants for MYCBP Gene

Variation tolerance for MYCBP Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCBP Gene

HapMap Linkage Disequilibrium report
MYCBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MYCBP Gene

Disorders for MYCBP Gene

Relevant External Links for MYCBP

Genetic Association Database (GAD)
MYCBP
Human Genome Epidemiology (HuGE) Navigator
MYCBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCBP

No disorders were found for MYCBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBP Gene

Publications for MYCBP Gene

  1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PMID: 9797456) Taira T. … Ariga H. (Genes Cells 1998) 2 3 4 23 67
  2. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. (PMID: 12414807) Furusawa M. … Ariga H. (J. Biol. Chem. 2002) 3 23
  3. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H. … Ariga H. (Biochim. Biophys. Acta 2002) 3 23
  4. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PMID: 12223483) Yukitake H. … Ariga H. (J. Biol. Chem. 2002) 3 23
  5. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PMID: 11483602) Furusawa M. … Ariga H. (J. Biol. Chem. 2001) 3 23

Products for MYCBP Gene

Sources for MYCBP Gene

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