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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYCBP Gene

protein-coding   GIFtS: 55
GCID: GC01M039328

MYC Binding Protein

(Previous name: c-myc binding protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MYC Binding Protein1 2     C-Myc-Binding Protein2
C-Myc Binding Protein1 2     AMY13
Associate Of Myc-11 2     Associate Of Myc 13
AMY-12 3     

External Ids:    HGNC: 75541   Entrez Gene: 262922   Ensembl: ENSG000002141147   OMIM: 6065355   UniProtKB: Q994173   
ORGUL members:         
NONCODE14:n410490 n410493 n410491 n410492      

Export aliases for MYCBP gene to outside databases

Previous GC identifers: GC01M039252 GC01M038336 GC01M038792 GC01M038741 GC01M038997 GC01M039101 GC01M037446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYCBP Gene:
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of
C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it
translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be
involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one
protein-coding and the other probably not protein-coding, have been found for this gene. (provided by RefSeq, Nov
2011)

GeneCards Summary for MYCBP Gene: 
MYCBP (MYC binding protein) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MYCBP include pterygium, and gastric cancer. GO annotations related to this gene include protein binding and transcription coactivator activity.

UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
Function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent
transcription by MYC

Gene Wiki entry for MYCBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYCBP gene promoter:
         SRF   SRF (504 AA)   AP-2gamma   NF-AT   C/EBPalpha   HFH-1   AP-2beta   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYCBP promoter sequence
   Search SABiosciences Chromatin IP Primers for MYCBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYCBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32.2   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p33-p32.2

MYCBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYCBP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M039328:  view genomic region     (about GC identifiers)

Start:
39,328,162 bp from pter      End:
39,347,289 bp from pter
Size:
19,128 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MYCBP

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417 (See protein sequence)
Recommended Name: C-Myc-binding protein  
Size: 103 amino acids; 11967 Da
Subunit: Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84.
Interacts with MYCBPAP
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the
cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1
1 PDB 3D structure from and Proteopedia for MYCBP:
2YY0 (3D)    
Secondary accessions: B2R4N0 Q5TA64 Q96HE2

Explore the universe of human proteins at neXtProt for MYCBP: NX_Q99417

Explore proteomics data for MYCBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99417

  • MYCBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYCBP Protein Expression
    REFSEQ proteins: NP_036465.2  
    ENSEMBL proteins: 
     ENSP00000380702  

    Human Recombinant Protein Products for MYCBP: 
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    Cloud-Clone Corp. Proteins for MYCBP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9797456
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IDA--

    MYCBP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026060 AMY1

    Graphical View of Domain Structure for InterPro Entry Q99417

    ProtoNet protein and cluster: Q99417

    UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
    Similarity: Belongs to the AMY1 family


    MYCBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYCBP_HUMAN, Q99417
    Function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent
    transcription by MYC

         Genatlas biochemistry entry for MYCBP:
    c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC)
    expression,stimulating the activation of the E-box regulated transcription by MYC/MAX

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA9797456
    GO:0005515protein binding IPI12151104
         
    MYCBP for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate MYCBP (see all 88):
    hsa-miR-579 hsa-miR-520f hsa-miR-361-5p hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-759 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMYCBP 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYCBP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Notch signaling pathway


    1 BioSystems Pathway for MYCBP
        Notch signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYCBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/73 Interacting proteins for MYCBP (Q994171, 2, 3 ENSP000003807024) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF40Q8TER52, 3, ENSP000002986944MINT-65269 I2D: score=5 STRING: ENSP00000298694
    PTCHD2Q9P2K92, 3, ENSP000002944844MINT-65267 I2D: score=5 STRING: ENSP00000294484
    CFL1P235282, 3MINT-65265 I2D: score=5 
    GDF9O603832, 3MINT-65263 I2D: score=5 
    PTNP212462, 3MINT-65264 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA9797456
    GO:0007283spermatogenesis IEP12151104

    MYCBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYCBP

    Search CenterWatch for drugs/clinical trials and news about MYCBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYCBP gene: 
    NM_012333.4  

    Unigene Cluster for MYCBP:

    C-myc binding protein
    Hs.591506  [show with all ESTs]
    Unigene Representative Sequence: NR_037633
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397572(uc001ccs.3 uc021olq.1) ENST00000494695 ENST00000495043
    ENST00000489803 ENST00000489575 ENST00000465771 ENST00000462027
    miRNA
    Products:
         
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    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate MYCBP (see all 88):
    hsa-miR-579 hsa-miR-520f hsa-miR-361-5p hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-759 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMYCBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYCBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYCBP
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYCBP

    Additional mRNA sequence: 

    AB007191.2 AB451287.1 AB451419.1 AF271261.1 AK095035.1 AK311886.1 AK312811.1 BC008686.1 
    BT007109.1 CR456936.1 D50692.1 NR_037632.1 NR_037633.1 NR_037634.1 NR_037635.1 NR_037636.1 
    NR_037637.1 

    15 DOTS entries:

    DT.445919  DT.100794114  DT.95309954  DT.97845735  DT.100794113  DT.95076061  DT.121348351  DT.95076062 
    DT.97811754  DT.101975994  DT.75138988  DT.75172997  DT.121348334  DT.95076077  DT.95308659 

    24/538 AceView cDNA sequences (see all 538):

    CB044952 BF001242 AA495838 BE502536 BQ128073 BU786953 CR601874 T32367 
    BM850343 BT007109 BM906174 CD672478 AW513447 AY126343 BU947961 BU579993 
    R35407 BU947399 AU123841 CB159363 BQ426018 BQ015285 BM749263 BI771507 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYCBP expression in normal human tissues (normalized intensities)      MYCBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCGTGAG
    MYCBP Expression
    About this image


    MYCBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Epidermis (Integumentary System)
             Spinous Keratinocytes Stratified Epidermis
     
     Bone (Muscoskeletal System)
             mandibular prominence tissue e10.0   
     
     Inner Cell Mass (Early Embryonic Tissues)
             201B6
     
     Spinal Cord (Nervous System)
             motor neurons   

    See MYCBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYCBP

    SOURCE GeneReport for Unigene cluster: Hs.591506

    UniProtKB/Swiss-Prot: MYCBP_HUMAN, Q99417
    Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low
    levels in lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MYCBP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mycbp1 , 5 c-myc binding protein1, 5 95.15(n)1
    97.09(a)1
      4 (57.42 cM)5
    563091  NM_019660.31  NP_062634.21 
     1239048325 
    chicken
    (Gallus gallus)
    Aves MYCBP1 c-myc binding protein 81.55(n)
    87.38(a)
      770496  XM_001232873.2  XP_001232874.2 
    lizard
    (Anolis carolinensis)
    Reptilia MYCBP6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343426.1(760973-762000)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64912 Xenopus laevis transcribed sequence with moderate similarity more 74.85(n)    AW633953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL908806.12   -- 76.73(n)    AL908806.1 


    ENSEMBL Gene Tree for MYCBP (if available)
    TreeFam Gene Tree for MYCBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYCBP gene

    MYCBP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MYCBP
    PGOHUM00000249168 PGOHUM00000240024


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYCBP
    DNA2.0 Custom Variant and Variant Library Synthesis for MYCBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606535    OMIM disorders: --

    2 diseases for MYCBP:    About MalaCards
    pterygium    gastric cancer


    MYCBP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYCBP
    Human Genome Epidemiology (HuGE) Navigator: MYCBP (1 document)

    Export disorders for MYCBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYCBP gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MYCBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PubMed id 9797456)1, 2, 3, 9 Taira T.... Ariga H. (1998)
    2. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PubMed id 11483602)1, 2, 9 Furusawa M.... Ariga H. (2001)
    3. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PubMed id 12151104)1, 2, 9 Yukitake H.... Ariga H. (2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PubMed id 12223483)1, 9 Yukitake H.... Ariga H. (2002)
    8. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. (PubMed id 12414807)1, 9 Furusawa M....Ariga H. (2002)
    9. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26292 HGNC: 7554 AceView: MYCBPandRHBDL2andRRAGCandGJA10 Ensembl:ENSG00000214114 euGenes: HUgn26292
    ECgene: MYCBP H-InvDB: MYCBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYCBP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYCBP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYCBP gene:
    Search GeneIP for patents involving MYCBP

    GeneCards and IP:
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