Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYCBP Gene

Aliases for MYCBP Gene

  • MYC Binding Protein 2 3 5
  • C-Myc Binding Protein 2 3
  • Associate Of Myc-1 2 3
  • AMY-1 3 4
  • C-Myc-Binding Protein 3
  • Associate Of Myc 1 4
  • AMY1 4

External Ids for MYCBP Gene

Previous GeneCards Identifiers for MYCBP Gene

  • GC01M039252
  • GC01M038336
  • GC01M038792
  • GC01M038741
  • GC01M038997
  • GC01M039101
  • GC01M039328
  • GC01M037446

Summaries for MYCBP Gene

Entrez Gene Summary for MYCBP Gene

  • The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MYCBP Gene

MYCBP (MYC Binding Protein) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG). GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000274944.

UniProtKB/Swiss-Prot for MYCBP Gene

  • May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

Gene Wiki entry for MYCBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBP Gene

Genomics for MYCBP Gene

Regulatory Elements for MYCBP Gene

Enhancers for MYCBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F039025 1.1 ENCODE 36.4 -152.5 -152461 2.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 NDUFS5 MYCBP LOC101929516 PPIEL AKIRIN1 SNORA55 GJA9 RRAGC LOC105378663 GC01M038902
GH01F038557 1.3 Ensembl ENCODE 29.9 +314.7 314718 2.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SF3A3 GNL2 MYCBP INPP5B RSPO1 LOC105378658 GC01P038607
GH01F038984 1.3 Ensembl ENCODE 17.8 -112.1 -112114 2.5 PKNOX1 ZFP64 YY1 ZNF121 FOS ZNF263 REST TSHZ1 ZNF518A ZNF623 PPIEL SF3A3 NDUFS5 MYCBP LOC101929516 SNORA55 AKIRIN1 EIF1P2
GH01F038726 1.9 VISTA FANTOM5 Ensembl ENCODE 11.4 +146.0 146037 2.3 HDGF PKNOX1 SIN3A RAD21 ZNF335 ZNF121 GLIS2 ZNF366 SCRT2 ZNF143 SF3A3 MYCBP LOC101929516 LOC105378660 LOC400750
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYCBP on UCSC Golden Path with GeneCards custom track

Promoters for MYCBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164746 705 2001 HDGF ATF1 PKNOX1 ARID4B SIN3A GLI4 DMAP1 ZNF48 YY1 ZNF121

Genomic Location for MYCBP Gene

38,862,490 bp from pter
38,874,105 bp from pter
11,616 bases
Minus strand

Genomic View for MYCBP Gene

Genes around MYCBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBP Gene

Proteins for MYCBP Gene

  • Protein details for MYCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-Myc-binding protein
    Protein Accession:
    Secondary Accessions:
    • B2R4N0
    • Q5TA64
    • Q96HE2

    Protein attributes for MYCBP Gene

    103 amino acids
    Molecular mass:
    11967 Da
    Quaternary structure:
    • Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.

    Three dimensional structures from OCA and Proteopedia for MYCBP Gene

neXtProt entry for MYCBP Gene

Post-translational modifications for MYCBP Gene

  • Ubiquitination at Lys 5 and Lys 20
  • Modification sites at PhosphoSitePlus

Other Protein References for MYCBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MYCBP
  • Cloud-Clone Corp. Antibodies for MYCBP
  • Santa Cruz Biotechnology (SCBT) Antibodies for MYCBP

No data available for DME Specific Peptides for MYCBP Gene

Domains & Families for MYCBP Gene

Protein Domains for MYCBP Gene


Suggested Antigen Peptide Sequences for MYCBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AMY1 family.
  • Belongs to the AMY1 family.
genes like me logo Genes that share domains with MYCBP: view

No data available for Gene Families for MYCBP Gene

Function for MYCBP Gene

Molecular function for MYCBP Gene

GENATLAS Biochemistry:
c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC) expression,stimulating the activation of the E-box regulated transcription by MYC/MAX
UniProtKB/Swiss-Prot Function:
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

Gene Ontology (GO) - Molecular Function for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 9797456
GO:0005515 protein binding IPI 12151104
genes like me logo Genes that share ontologies with MYCBP: view
genes like me logo Genes that share phenotypes with MYCBP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYCBP Gene

Localization for MYCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBP Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCBP gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9797456
GO:0005737 cytoplasm IEA,IDA 9797456
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MYCBP: view

Pathways & Interactions for MYCBP Gene

SuperPathways for MYCBP Gene

SuperPathway Contained pathways
1 Notch signaling pathway (KEGG)
genes like me logo Genes that share pathways with MYCBP: view

Pathways by source for MYCBP Gene

1 BioSystems pathway for MYCBP Gene

Gene Ontology (GO) - Biological Process for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 9797456
GO:0007283 spermatogenesis IEP 12151104
genes like me logo Genes that share ontologies with MYCBP: view

No data available for SIGNOR curated interactions for MYCBP Gene

Transcripts for MYCBP Gene

Unigene Clusters for MYCBP Gene

C-myc binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBP Gene

No ASD Table

Relevant External Links for MYCBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYCBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYCBP Gene

This gene is overexpressed in Lavage (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYCBP Gene

Protein tissue co-expression partners for MYCBP Gene

NURSA nuclear receptor signaling pathways regulating expression of MYCBP Gene:


SOURCE GeneReport for Unigene cluster for MYCBP Gene:


mRNA Expression by UniProt/SwissProt for MYCBP Gene:

Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
genes like me logo Genes that share expression patterns with MYCBP: view

No data available for mRNA differential expression in normal tissues for MYCBP Gene

Orthologs for MYCBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYCBP 34 35
  • 100 (n)
(Bos Taurus)
Mammalia MYCBP 34 35
  • 97.09 (n)
(Canis familiaris)
Mammalia MYCBP 34 35
  • 96.76 (n)
(Mus musculus)
Mammalia Mycbp 34 16 35
  • 95.15 (n)
(Rattus norvegicus)
Mammalia Mycbp 34
  • 94.17 (n)
(Ornithorhynchus anatinus)
Mammalia MYCBP 35
  • 92 (a)
(Gallus gallus)
Aves MYCBP 34 35
  • 81.55 (n)
(Anolis carolinensis)
Reptilia MYCBP 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbp 34
  • 72.49 (n)
Str.10099 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6491 34
(Danio rerio)
Actinopterygii mycbp 34 35
  • 61.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4055 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4517 34
Species where no ortholog for MYCBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBP Gene

Gene Tree for MYCBP (if available)
Gene Tree for MYCBP (if available)

Paralogs for MYCBP Gene

Paralogs for MYCBP Gene Pseudogenes for MYCBP Gene

genes like me logo Genes that share paralogs with MYCBP: view

Variants for MYCBP Gene

Sequence variations from dbSNP and Humsavar for MYCBP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050463 -- 38,864,183(-) ACATG(A/G)AACAA nc-transcript-variant, utr-variant-3-prime
rs1050468 -- 38,863,663(-) CACTC(A/C)CTAAC nc-transcript-variant, utr-variant-3-prime
rs111542273 -- 38,869,148(+) CAATG(A/G)CATAA intron-variant
rs111622420 -- 38,871,011(+) GAGGT(A/G)AGCGG intron-variant
rs111965860 -- 38,871,000(+) TCTGC(A/G)GGGCT intron-variant

Variation tolerance for MYCBP Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYCBP Gene

Disorders for MYCBP Gene

Relevant External Links for MYCBP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MYCBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBP Gene

Publications for MYCBP Gene

  1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PMID: 9797456) Taira T. … Ariga H. (Genes Cells 1998) 2 3 4 22 64
  2. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H. … Ariga H. (Biochim. Biophys. Acta 2002) 3 4 22 64
  3. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PMID: 11483602) Furusawa M. … Ariga H. (J. Biol. Chem. 2001) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MYCBP Gene

Sources for MYCBP Gene

Loading form....