Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYCBP Gene

Aliases for MYCBP Gene

  • MYC Binding Protein 2 3
  • C-Myc Binding Protein 2 3
  • Associate Of Myc-1 2 3
  • AMY-1 3 4
  • C-Myc-Binding Protein 3
  • Associate Of Myc 1 4
  • AMY1 4

External Ids for MYCBP Gene

Summaries for MYCBP Gene

Entrez Gene Summary for MYCBP Gene

  • The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MYCBP Gene

MYCBP (MYC Binding Protein) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (Pathway Interaction Database). GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for MYCBP Gene

  • May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC

Gene Wiki entry for MYCBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBP Gene

Genomics for MYCBP Gene

Genomic Location for MYCBP Gene

Start:
38,862,490 bp from pter
End:
38,874,495 bp from pter
Size:
12,006 bases
Orientation:
Minus strand

Genomic View for MYCBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBP Gene

Regulatory Elements for MYCBP Gene

Proteins for MYCBP Gene

  • Protein details for MYCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99417-MYCBP_HUMAN
    Recommended name:
    C-Myc-binding protein
    Protein Accession:
    Q99417
    Secondary Accessions:
    • B2R4N0
    • Q5TA64
    • Q96HE2

    Protein attributes for MYCBP Gene

    Size:
    103 amino acids
    Molecular mass:
    11967 Da
    Quaternary structure:
    • Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.

    Three dimensional structures from OCA and Proteopedia for MYCBP Gene

neXtProt entry for MYCBP Gene

Proteomics data for MYCBP Gene at MOPED

Post-translational modifications for MYCBP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5 and Lys20

Other Protein References for MYCBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYCBP Gene

Domains for MYCBP Gene

Protein Domains for MYCBP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MYCBP_HUMAN
Family:
  • Belongs to the AMY1 family.:
    • Q99417
genes like me logo Genes that share domains with MYCBP: view

No data available for Gene Families for MYCBP Gene

Function for MYCBP Gene

Molecular function for MYCBP Gene

GENATLAS Biochemistry: c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC) expression,stimulating the activation of the E-box regulated transcription by MYC/MAX
UniProtKB/Swiss-Prot Function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC

Gene Ontology (GO) - Molecular Function for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 9797456
GO:0005515 protein binding IPI 12151104
genes like me logo Genes that share ontologies with MYCBP: view

miRNA for MYCBP Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYCBP Gene

Localization for MYCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBP Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYCBP Gene COMPARTMENTS Subcellular localization image for MYCBP gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9797456
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with MYCBP: view

Pathways for MYCBP Gene

genes like me logo Genes that share pathways with MYCBP: view

Pathways by source for MYCBP Gene

1 BioSystems pathway for MYCBP Gene

Gene Ontology (GO) - Biological Process for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 9797456
GO:0007283 spermatogenesis IEP 12151104
genes like me logo Genes that share ontologies with MYCBP: view

Transcripts for MYCBP Gene

Unigene Clusters for MYCBP Gene

C-myc binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBP Gene

No ASD Table

Relevant External Links for MYCBP Gene

GeneLoc Exon Structure for
MYCBP
ECgene alternative splicing isoforms for
MYCBP

Expression for MYCBP Gene

mRNA expression in normal human tissues for MYCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYCBP Gene

SOURCE GeneReport for Unigene cluster for MYCBP Gene Hs.591506

mRNA Expression by UniProt/SwissProt for MYCBP Gene

Q99417-MYCBP_HUMAN
Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung
genes like me logo Genes that share expressions with MYCBP: view

Orthologs for MYCBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCBP 36
  • 100 (n)
  • 100 (a)
MYCBP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYCBP 36
  • 97.09 (n)
  • 99.03 (a)
MYCBP 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYCBP 36
  • 96.76 (n)
  • 99.03 (a)
MYCBP 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycbp 36
  • 95.15 (n)
  • 97.09 (a)
Mycbp 16
Mycbp 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCBP 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycbp 36
  • 94.17 (n)
  • 97.09 (a)
chicken
(Gallus gallus)
Aves MYCBP 36
  • 81.55 (n)
  • 87.38 (a)
MYCBP 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCBP 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6491 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbp 36
  • 72.49 (n)
  • 78.64 (a)
Str.10099 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4055 36
zebrafish
(Danio rerio)
Actinopterygii mycbp 36
  • 61.76 (n)
  • 63.73 (a)
mycbp 37
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4517 36
Species with no ortholog for MYCBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBP Gene

ENSEMBL:
Gene Tree for MYCBP (if available)
TreeFam:
Gene Tree for MYCBP (if available)

Paralogs for MYCBP Gene

Pseudogenes.org Pseudogenes for MYCBP Gene

genes like me logo Genes that share paralogs with MYCBP: view

No data available for Paralogs for MYCBP Gene

Variants for MYCBP Gene

Relevant External Links for MYCBP Gene

HapMap Linkage Disequilibrium report
MYCBP

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MYCBP Gene

Disorders for MYCBP Gene

Relevant External Links for MYCBP

Genetic Association Database (GAD)
MYCBP
Human Genome Epidemiology (HuGE) Navigator
MYCBP
genes like me logo Genes that share disorders with MYCBP: view

No data available for UniProtKB/Swiss-Prot for MYCBP Gene

Publications for MYCBP Gene

  1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PMID: 9797456) Taira T. … Ariga H. (Genes Cells 1998) 2 3 4 23
  2. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP- dependent protein kinase. (PMID: 11483602) Furusawa M. … Ariga H. (J. Biol. Chem. 2001) 3 4 23
  3. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H. … Ariga H. (Biochim. Biophys. Acta 2002) 3 4 23
  4. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. (PMID: 12223483) Yukitake H. … Ariga H. (J. Biol. Chem. 2002) 3 23
  5. AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. (PMID: 12414807) Furusawa M. … Ariga H. (J. Biol. Chem. 2002) 3 23

Products for MYCBP Gene

Sources for MYCBP Gene

Back to Top

Content