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MYC Gene

protein-coding GIFtS: 71

GC08P128817

v-myc myelocytomatosis viral oncogene homolog (avian)
(Previous name: v-myc avian myelocytomatosis viral oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MRTL ^²
bHLHe39 ^¹, ²
c-Myc ^¹, ², ³

Descriptions
Transcription factor p64 ^³
avian myelocytomatosis viral oncogene homolog ^²
myc proto-oncogene protein ^²
myc-related translation/localization regulatory factor ^²
v-myc avian myelocytomatosis viral oncogene homolog ^¹, ²
v-myc myelocytomatosis viral oncogene homolog (avian) ^²

External Ids
HGNC: 7553¹
Entrez Gene: 4609²
UniProtKB: P01106³
Ensembl: ENSG00000136997⁷

Search outside databases for aliases for MYC gene

Previous GC identifers: GC08P127757 GC08P128836 GC08P128419 GC08P128705

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MYC:

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in

cell cycle progression, apoptosis and cellular transformation. It functions as a transcription

factor that regulates transcription of specific target genes. Mutations, overexpression,

rearrangement and translocation of this gene have been associated with a variety of hematopoietic

tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that

alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG

start site result in the production of two isoforms with distinct N-termini. The synthesis of

non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in

the normal function of this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106

Function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific

manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate

the transcription of growth-related genes

Gene Wiki entry for MYC (Myc)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYC gene

Entrez Gene cytogenetic band: 8q24.21 Ensembl cytogenetic band: 8q24.21 HGNC cytogenetic band: 8q24

MYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P128817: (about GC identifiers)

Start:	128,816,862 bp from pter
End:	128,822,856 bp from pter
Size:	5,995 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106 (See protein sequence)

Recommended Name: Myc proto-oncogene protein

Size: 439 amino acids; 48804 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a

heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A

and KDM5B

Subcellular location: Nucleus

Sequence caution: Sequence=BAA01374.2; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1A93 (3D)

1EE4 (3D)

1MV0 (3D)

1NKP (3D)

2A93 (3D)

Secondary accessions: P01107 Q14026

Post-translational modifications:

Phosphorylated by PRKDC¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002458.2

ENSEMBL proteins:

ENSP00000259523 ENSP00000367207

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (c-Myc)
	Human Recombinant Proteins from Abnova (MYC)

OriGene Purified Recombinant Human Protein: MYC

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15994933
GO:0005737	cytoplasm	IEA	--
GO:0005819	spindle	IEA	--
GO:0016604	nuclear body	IEA	--

About this table

Antibodies for MYC:

	Invitrogen Antibodies for MYC
	Millipore Mono- and Polyclonal Antibodies for the study of MYC
	Sigma-Aldrich Antibody Arrays and Antibodies for MYC
	R&D Systems Antibodies for MYC (c-Myc)
	Cell Signaling Technology (CST) Antibodies for MYC (c-Myc)
	Antibodies from Abcam (c-Myc), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MYC)
	Novus Biologicals Antibodies for MYC

Assays for MYC:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of MYC
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01106

ProtoNet protein and cluster: P01106

3 Blocks protein families:

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB002418 Myc proto-oncogene signature

IPB003327 Leucine zipper

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYC)
		Millipore RNAi Products for the Analysis of MYC Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MYC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002467

Applied Biosystems Silencer® siRNAs for MYC

Sigma-Aldrich siRNA for MYC

Sigma-Aldrich shRNA Panels and shRNA for MYC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MYC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002467
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002467
untagged cDNA clones in CMV expression vector (see all 2): NM_002467

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002467

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106

Function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific

manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate

the transcription of growth-related genes

Genatlas biochemistry entry for MYC:

Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response

gene,interacting with various cellular factors including MAX,YY1,AMPHL, for binding E box

recognition sites,stimulating genes required for proliferation,also inducing apoptosis in

sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)

15/24 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Myc) (see all 24 ):

	adipose tissue	behavior/neurological	cellular	craniofacial
digestive/alimentary	embryogenesis	growth/size	hearing/vestibular/ear	hematopoietic system
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	transcription factor activity	TAS	9924025
GO:0005515	protein binding	IPI	9308237 9708738 10597290 12706874
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for MYC (Your Favorite Gene powered by Ingenuity) (see all 18 )

Prolactin Signaling
Small Cell Lung Cancer Signaling
Bladder Cancer Signaling
Endometrial Cancer Signaling
Chronic Myeloid Leukemia Signaling

GeneDecks MYC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MYC

5/393 Interacting proteins for MYC (ENSP00000367207³ P01106^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 393 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EP300	Q09472¹	STRING (score=.993) EBI-447544, EBI-447295
FBXW7	Q969H0¹	STRING (score=.993) EBI-447544, EBI-359574
PIAS2	O75928¹	STRING (score=.992) EBI-447544, EBI-348555
SKP2	Q13309¹	STRING (score=.992) EBI-447544, EBI-456291
SNIP1	Q8TAD8¹	STRING (score=.839) EBI-447544, EBI-749336

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5/24 Gene Ontology (GO) biological process terms (links to tree view) (see all 24 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001783	B cell apoptosis	IEA	--
GO:0001836	release of cytochrome c from mitochondria	IEA	--
GO:0006006	glucose metabolic process	IEA	--
GO:0006309	DNA fragmentation during apoptosis	IEA	--
GO:0006352	transcription initiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MYC

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MYC
10/37 Novoseek chemical compound relationships for MYC gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine	61.65	86	9683527 (3), 11306486 (2), 8297793 (2), 11598794 (2) (see all 66)
tyrosine	55.02	95	7642726 (5), 14634284 (3), 8790838 (3), 11960624 (2) (see all 70)
cb 33	54.06	2	10891489 (1), 11598121 (1)
thymidine	53.82	55	2187953 (3), 2105952 (2), 1709176 (2), 19149928 (2) (see all 35)
12-o-tetradecanoylphorbol 13-acetate	51.48	54	1688464 (3), 10511314 (3), 8518229 (3), 9301678 (2) (see all 26)
delta 7-pga1	47.52	2	8862010 (2)
oligonucleotide	45.77	91	7923012 (10), 7647959 (7), 1485890 (3), 1855215 (3) (see all 43)
leucine	44.40	52	7577944 (3), 7727380 (3), 8423990 (2), 11891322 (2) (see all 41)
bryostatin 1	43.51	16	9337072 (3), 8870649 (3), 10918054 (2), 9770354 (1) (see all 7)
wp631	43.15	5	11960601 (2), 11172687 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYC)
		Millipore RNAi Products for the Analysis of MYC Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MYC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002467

Sigma-Aldrich siRNA for MYC

Sigma-Aldrich shRNA Panels and shRNA for MYC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002467

REFSEQ mRNAs for MYC gene:

NM_002467.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002467

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002467
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002467
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002467

24/246 AceView cDNA sequences (see all 246 ):

BM832775 BX110338 CR609560 BU507458 BQ433670 M13930 W87741 X66258

CA446124 BC000141 CR618399 BF063312 BQ632551 BC000917 BQ225726 M13929

AI278350 AW675223 BF001576 BM742710 AA514409 BC058901 AL047400 NM_002467

highest scoring ESTs for MYC:

V00568 AA235530 AA304930 AA344094 AA464600 AA477744 AA477850 AA514409 AA527483 AA550843

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MYC

ExUns:	1a	·	1b	^	2a	·	2b	^	3
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for MYC

2 Ensembl transcripts including schematic representations:

ENST00000259523 ENST00000377970

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MYC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYC

¹ / ² / ³

6 probe-sets matching MYC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1827_s_at²^{, 3}	U95-A	1	1.00	1.00	0.31	1.23	M13929	0.80	0.67	0.74	1
1936_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.04	HG3523-HT4899	0.20	0.50	0.38	1
1973_s_at²^{, 3}	U95-A	2	1.00	0.97	0.96	0.94	V00568	1.00	0.90	0.95	1
37724_at²^{, 3}	U95-A	2	1.00	0.94	0.95	0.82	V00568	1.00	0.90	0.95	1
202431_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_002467	0.60	1.00	0.82	1
202431_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks MYC for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATCAAATGCA
Expression variation in blood from EXPOLDB for MYC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYC gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYC¹	--	v-myc myelocytomatosis viral oncogene homolog (avian)	91.72(n) 94.08(a)	403924 NM_001003246.1 NP_001003246.1
chimpanzee (Pan troglodytes)	MYC¹	--	v-myc myelocytomatosis viral oncogene homolog (avian)	99.63(n) 99.12(a)	464393 XM_519958.2 XP_519958.2
cow (Bos taurus)	MYC¹	--	v-myc myelocytomatosis viral oncogene homolog (avian)	90.13(n) 92.03(a)	511077 NM_001046074.1 NP_001039539.1
rat (Rattus norvegicus)	Myc¹	--	myelocytomatosis oncogene	87.32(n) 90.27(a)	24577 NM_012603.2 NP_036735.2
mouse (Mus musculus)	Myc^{1, 5}	15 (32.00 cM)⁵	myelocytomatosis oncogene^{1, 5}	87.93(n)¹ 90.29(a)¹	17869¹ NM_010849.4¹ NP_034979.3¹ AF076523⁵ AF519452⁵ (see all 31)

About this table Species with no ortholog for MYC

ENSEMBL Gene Tree for MYC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYC gene

MYCL2² MYCN² MYCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in MYC are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2070583^1,2	C,F,H,O	128822436(+)	`CAATCA/GCCTAT`	1	--	ut3¹		15	EA NS NA MN CSAM EU WA	2704
	rs17187428^1,2	C,F,H	128815526(+)	`GCGATG/AATCTC`	1	--	ng5¹		11	NA EU EA WA	982
	rs4645945^1,2	C,F,H	128817070(+)	`CCCAGC/GCTTAG`	1	--	ng5¹		10	NS MN CSAM EA EU WA	986
	rs4645959^1,2	C,F,H	128819722(+)	`CAGGAA/GCTATG`	1	N/S	mis¹ ese³		12	NS EU EA WA NA	1154
	rs3824120^1,2	C,F,H	128817135(-)	`CACACC/AGAGAA`	1	--	ng5¹		9	NS EA WA MN CSAM	846
	rs4645943^1,2	C,F,H	128816653(+)	`CCTAGC/TCCAGC`	1	--	ng5¹		5	NS EU EA WA	584
	rs4645948^1,2	C,F,H	128817680(+)	`TCCAGC/TGAGAG`	1	--	ut5¹ ese³		16	NS EU EA WA NA MN	1748
	rs4645961^1,2	C,F	128820198(+)	`ACAGCG/ATCTGC`	1	I/V	mis¹ ese³		4	NS NA	302
	rs4645968^1,2	F,H	128822031(+)	`TGCTGC/TCAAGA`	1	A/V	mis¹ ese³		5	NS EU EA WA	594
	rs4645970^1,2	C,H	128822515(+)	`TAGCCA/GTAATG`	1	--	ut3¹		10	NS MN CSAM EA EU WA	978

About this table

HapMap Linkage Disequilibrium images for MYC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 190080 disorders: 113970

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106

Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors

A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic

lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1

10/91 Novoseek disease relationships for MYC gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
burkitt lymphoma	84.49	253	7558417 (5), 2307371 (5), 1945409 (5), 10713166 (5) (see all 99)
tumors	79.08	1640	11526483 (7), 12769686 (6), 17906696 (5), 17664422 (5) (see all 99)
cancer	71.18	506	18221043 (5), 16856965 (4), 18197790 (3), 11467449 (3) (see all 99)
retinoblastoma	70.34	81	7609100 (4), 1865909 (2), 8959329 (2), 1309437 (2) (see all 65)
lymphoma	67.79	222	11431360 (6), 8919541 (4), 9196434 (4), 2200538 (4) (see all 99)
lymphoma b-cell	66.83	58	12594230 (4), 8062825 (2), 11182042 (2), 17701581 (2) (see all 43)
myeloid leukemia	66.60	28	7500645 (2), 8810318 (1), 1901940 (1), 16185479 (1) (see all 24)
leukemia	64.85	155	16855632 (5), 7739203 (5), 11734062 (4), 8260894 (3) (see all 91)
neoplastic transformation	63.76	24	2233723 (1), 10409758 (1), 7574421 (1), 11270800 (1) (see all 22)
breast cancer	63.66	306	17052904 (5), 11948489 (4), 15757889 (4), 16202165 (4) (see all 99)

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1 PharmGKB disease relationship for MYC gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genatlas disease: MYC

Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations

t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

Human Gene Mutation Database: MYC
Genetic Association Database: MYC
Human Genome Epidemiology Navigator: MYC (39 documents)
Tumor Gene Database: MYC
Breast Cancer Gene Database: MYC

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/3239 PubMed articles for MYC gene (see all 3239 ):

Six lysine residues on c-Myc are direct substrates for acetylation by p300. (PubMed id 16126174)^{1, 3, 4} Zhang K.... Martinez E. (2005)
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. (PubMed id 9680483)^{1, 3, 4} Lavigne P.... Sykes B.D. (1998)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. (PubMed id 15723054)^{3, 4} Grandori C.... White R.J. (2005)
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{3, 6} Nan H.M....Kim H. (2005)
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. (PubMed id 15674325)^{3, 4} Yu M.... Luescher B. (2005)
c-MYC Asn11Ser is associated with increased risk for familial breast cancer. (PubMed id 15929079)^{3, 6} Wirtenberger M....Burwinkel B. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
c-Raf kinase binds to N-terminal domain of c-Myc. (PubMed id 9315742)^{3, 4} Alexandrov I....Alexandrova N. (1997)
c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. (PubMed id 7642555)^{3, 4} Chou T.-Y.... Dang C.V. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4609	HGNC: 7553	AceView: MYC	Ensembl:ENSG00000136997	euGenes: HUgn4609
ECgene: MYC	H-InvDB: MYC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MYC	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/myc/
Wikipedia	http://en.wikipedia.org/wiki/Myc

Licensable Technologies for MYC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MYC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYC		Antibodies for MYC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MYC)
	Antibodies (MYC)
	Chimera RNAi (MYC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MYC (c-Myc)

	Recombinant Proteins (c-Myc)
	Antibodies (c-Myc)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MYC

	Drugs for MYC
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MYC

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MYC Gene at Home site.
Version 2.41.1
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MYC Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for MYC

Summaries
for MYC

Genomic Location
for MYC

Proteins
for MYC

Protein Domains/
Families
for MYC

Gene Function
for MYC

Pathways & Interactions
for MYC

Drugs & Compounds
for MYC

Transcripts
for MYC

Expression
for MYC

Orthologs
for MYC

Paralogs
for MYC

SNPs/Variants
for MYC

Disorders & Mutations
for MYC

Medical News
for MYC

Publications
for MYC

Search for MYC

Genome Databases showing MYC

Other Databases showing MYC

Specialized Databases showing MYC

Licensable Technologies
for MYC

Services
for MYC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYC Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor MYC

Summariesfor MYC

Genomic Locationfor MYC

Proteinsfor MYC

Protein Domains/Familiesfor MYC

Gene Functionfor MYC

Pathways & Interactionsfor MYC

Drugs & Compoundsfor MYC

Transcriptsfor MYC

Expression for MYC

Orthologsfor MYC

Paralogsfor MYC

SNPs/Variantsfor MYC

Disorders & Mutationsfor MYC

Medical Newsfor MYC

Publicationsfor MYC

Search for MYC

Genome Databases showing MYC

Other Databases showing MYC

Specialized Databases showing MYC

Licensable Technologiesfor MYC

Servicesfor MYC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYC

Summaries
for MYC

Genomic Location
for MYC

Proteins
for MYC

Protein Domains/
Families
for MYC

Gene Function
for MYC

Pathways & Interactions
for MYC

Drugs & Compounds
for MYC

Transcripts
for MYC

Expression
for MYC

Orthologs
for MYC

Paralogs
for MYC

SNPs/Variants
for MYC

Disorders & Mutations
for MYC

Medical News
for MYC

Publications
for MYC

Licensable Technologies
for MYC

Services
for MYC