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Aliases for MYC Gene

Aliases for MYC Gene

  • MYC Proto-Oncogene, BHLH Transcription Factor 2 3 5
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 2 3
  • Class E Basic Helix-Loop-Helix Protein 39 3 4
  • Transcription Factor P64 3 4
  • Proto-Oncogene C-Myc 3 4
  • BHLHe39 3 4
  • Myc-Related Translation/Localization Regulatory Factor 3
  • Avian Myelocytomatosis Viral Oncogene Homolog 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 3
  • Myc Proto-Oncogene Protein 3
  • C-Myc 3
  • MRTL 3
  • MYCC 3

External Ids for MYC Gene

Previous GeneCards Identifiers for MYC Gene

  • GC08P127757
  • GC08P128836
  • GC08P128419
  • GC08P128705
  • GC08P128817
  • GC08P128748
  • GC08P124069

Summaries for MYC Gene

Entrez Gene Summary for MYC Gene

  • This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

CIViC summary for MYC Gene

GeneCards Summary for MYC Gene

MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement. Among its related pathways are Ectoderm Differentiation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYCN.

UniProtKB/Swiss-Prot for MYC Gene

  • Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

Gene Wiki entry for MYC Gene

Additional gene information for MYC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYC Gene

Genomics for MYC Gene

GeneHancer (GH) Regulatory Elements for MYC Gene

Promoters and enhancers for MYC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I127732 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.7 2668 11.6 ZFP64 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610 GC08P127736 GC08P127737 MYC SRRM1P1 RNU1-106P MIR1204 PVT1 TMEM75 CASC11 GC08P127740
GH08I128181 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +448.6 448601 5.1 HDGF FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 ZBTB7B SLC30A9 ZNF766 MYC MIR1208 MIR1207 CASC11 RNU1-106P TMEM75 RNU4-25P GC08P128172 GC08P128221
GH08I127806 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18 +75.4 75415 8.6 HDGF PKNOX1 NEUROD1 SIN3A YBX1 ZBTB7B BRCA1 GLIS2 E2F8 ZNF207 MYC SRRM1P1 CASC11 TMEM75 MIR1207 RNU1-106P PVT1 MIR1204 ENSG00000278324
GH08I127895 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +163.4 163354 5.9 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A YBX1 ZNF766 SRRM1P1 RNU1-106P MYC ENSG00000278324 TMEM75 PVT1
GH08I127758 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +24.7 24749 2.8 HDGF PKNOX1 ATF1 ARNT SIN3A BRCA1 NCOA2 ZNF766 ATF7 NCOA1 PVT1 MIR1204 MYC CASC11 TMEM75 MIR1207 RNU4-25P GC08P127744
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYC gene promoter:

Genomic Locations for MYC Gene

Genomic Locations for MYC Gene
chr8:127,735,434-127,741,434
(GRCh38/hg38)
Size:
6,001 bases
Orientation:
Plus strand
chr8:128,747,680-128,753,680
(GRCh37/hg19)

Genomic View for MYC Gene

Genes around MYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYC Gene

Proteins for MYC Gene

  • Protein details for MYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01106-MYC_HUMAN
    Recommended name:
    Myc proto-oncogene protein
    Protein Accession:
    P01106
    Secondary Accessions:
    • A8WFE7
    • P01107
    • Q14026

    Protein attributes for MYC Gene

    Size:
    439 amino acids
    Molecular mass:
    48804 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029).

    Three dimensional structures from OCA and Proteopedia for MYC Gene

    Alternative splice isoforms for MYC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYC Gene

Post-translational modifications for MYC Gene

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
  • Ubiquitination at isoforms=2389
  • Glycosylation at Thr58

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYC (Myc)

No data available for DME Specific Peptides for MYC Gene

Domains & Families for MYC Gene

Gene Families for MYC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYC: view

No data available for UniProtKB/Swiss-Prot for MYC Gene

Function for MYC Gene

Molecular function for MYC Gene

GENATLAS Biochemistry:
Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).

Phenotypes From GWAS Catalog for MYC Gene

Gene Ontology (GO) - Molecular Function for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10723141
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP 25956029
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10723141
GO:0003677 DNA binding TAS 10597290
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with MYC: view

Phenotypes for MYC Gene

MGI mutant phenotypes for MYC:
inferred from 21 alleles
GenomeRNAi human phenotypes for MYC:
genes like me logo Genes that share phenotypes with MYC: view

Human Phenotype Ontology for MYC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYC Gene

MGI Knock Outs for MYC:

miRNA for MYC Gene

miRTarBase miRNAs that target MYC

Transcription Factor Targets for MYC Gene

Selected GeneGlobe predicted Target genes for MYC
Targeted motifs for MYC Gene
HOMER Transcription Factor Regulatory Elements motif MYC
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

Clone Products

  • Addgene plasmids for MYC

No data available for Enzyme Numbers (IUBMB) for MYC Gene

Localization for MYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYC Gene

Nucleus, nucleoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYC gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IMP 12837246
GO:0005634 nucleus TAS,IDA 11793365
GO:0005635 nuclear envelope IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 17558397
genes like me logo Genes that share ontologies with MYC: view

Pathways & Interactions for MYC Gene

genes like me logo Genes that share pathways with MYC: view

Pathways by source for MYC Gene

SIGNOR curated interactions for MYC Gene

Gene Ontology (GO) - Biological Process for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 9924025
GO:0000165 MAPK cascade IMP 17873522
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001541 ovarian follicle development IEA --
genes like me logo Genes that share ontologies with MYC: view

Drugs & Compounds for MYC Gene

(78) Drugs for MYC Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved, Investigational Pharma Target, inhibitor 35
Alisertib Investigational Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
Dinaciclib Investigational Pharma inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0
10058-F4 Pharma C-Myc-Max dimerization inhibitor 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0

(67) Additional Compounds for MYC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MYC Gene

Compound Action Cas Number
10058-F4 C-Myc-Max dimerization inhibitor 403811-55-2
genes like me logo Genes that share compounds with MYC: view

Drug Products

Transcripts for MYC Gene

Unigene Clusters for MYC Gene

V-myc myelocytomatosis viral oncogene homolog (avian):
Representative Sequences:

Clone Products

  • Addgene plasmids for MYC

Alternative Splicing Database (ASD) splice patterns (SP) for MYC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2:

Relevant External Links for MYC Gene

GeneLoc Exon Structure for
MYC
ECgene alternative splicing isoforms for
MYC

Expression for MYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYC Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.9) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYC Gene



NURSA nuclear receptor signaling pathways regulating expression of MYC Gene:

MYC

SOURCE GeneReport for Unigene cluster for MYC Gene:

Hs.202453

Evidence on tissue expression from TISSUES for MYC Gene

  • Nervous system(4.2)
  • Intestine(3.8)
  • Blood(3.7)
  • Liver(3.5)
  • Bone marrow(3.2)
  • Lymph node(3.2)
  • Muscle(3.2)
  • Skin(3.1)
  • Lung(3)
  • Stomach(2.9)
  • Kidney(2.8)
  • Pancreas(2.8)
  • Heart(2.7)
  • Spleen(2.7)
  • Adrenal gland(2.4)
  • Thyroid gland(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MYC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • lymphatic
  • nervous
  • reproductive
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • skull
Abdomen:
  • intestine
Pelvis:
  • ovary
  • pelvis
  • testicle
General:
  • blood
  • bone marrow
  • lymph node
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MYC: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYC Gene

Orthologs for MYC Gene

This gene was present in the common ancestor of animals.

Orthologs for MYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYC 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia MYC 33 34
  • 91 (n)
cow
(Bos Taurus)
Mammalia MYC 33 34
  • 90.21 (n)
mouse
(Mus musculus)
Mammalia Myc 33 16
  • 87.49 (n)
Bmyc 34
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myc 33
  • 86.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYC 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYC 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYC 33 34
  • 75.9 (n)
lizard
(Anolis carolinensis)
Reptilia MYC 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76254 33 33
  • 70.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52595 33
zebrafish
(Danio rerio)
Actinopterygii mycb 33 34
  • 65.08 (n)
myca 34
  • 58 (a)
OneToMany
mych 34
  • 33 (a)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11908 33
fruit fly
(Drosophila melanogaster)
Insecta dm 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 11 (a)
OneToMany
Species where no ortholog for MYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYC Gene

ENSEMBL:
Gene Tree for MYC (if available)
TreeFam:
Gene Tree for MYC (if available)

Paralogs for MYC Gene

Paralogs for MYC Gene

genes like me logo Genes that share paralogs with MYC: view

Variants for MYC Gene

Sequence variations from dbSNP and Humsavar for MYC Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1057519849 likely-pathogenic, Neoplasm 127,738,386(+) C/T coding_sequence_variant, missense_variant
rs1057519850 likely-pathogenic, Neoplasm 127,738,447(+) C/T coding_sequence_variant, missense_variant
rs1057519851 likely-pathogenic, Neoplasm 127,738,995(+) C/G coding_sequence_variant, missense_variant
rs1057519918 likely-pathogenic, Malignant lymphoma, non-Hodgkin, Adenocarcinoma of lung, Carcinoma of esophagus, Neuroblastoma, Malignant melanoma of skin 127,738,390(+) C/T coding_sequence_variant, missense_variant
rs121918683 pathogenic, likely-pathogenic, Burkitt lymphoma, Neoplasm, A Burkitt lymphoma sample 127,738,519(+) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MYC Gene

Variant ID Type Subtype PubMed ID
esv2752208 CNV gain 17911159
esv3618781 CNV gain 21293372
nsv499795 OTHER inversion 21111241
nsv516713 CNV gain+loss 19592680
nsv7419 OTHER inversion 18451855
nsv831458 CNV loss 17160897

Variation tolerance for MYC Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYC Gene

Human Gene Mutation Database (HGMD)
MYC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYC Gene

Disorders for MYC Gene

MalaCards: The human disease database

(110) MalaCards diseases for MYC Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards