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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYC Gene

protein-coding   GIFtS: 74
GCID: GC08P128748

v-myc myelocytomatosis viral oncogene homolog (avian)

(Previous name: v-myc avian myelocytomatosis viral oncogene homolog )
 Explore 253 diseases affiliated with
MYC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYC    

Aliases
for MYC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian)1 2     Transcription Factor P642 3
BHLHe391     MRTL2
C-Myc1     Avian Myelocytomatosis Viral Oncogene Homolog2
V-Myc Avian Myelocytomatosis Viral Oncogene Homolog1 2     Myc Proto-Oncogene Protein2
Class E Basic Helix-Loop-Helix Protein 392 3     Myc-Related Translation/Localization Regulatory Factor2
Proto-Oncogene C-Myc2 3     BHLHE393

External Ids:    HGNC: 75531   Entrez Gene: 46092   Ensembl: ENSG000001369977   OMIM: 1900805   UniProtKB: P011063   

Export aliases for MYC gene to outside databases

Previous GC identifers: GC08P127757 GC08P128836 GC08P128419 GC08P128705 GC08P128817 GC08P124069


Summaries
for MYC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYC:
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle
progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates
transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have
been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is
evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream
AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated
protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
Function: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also
specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes

Gene Wiki entry for MYC (Myc)


Genomic Views
for MYC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYC gene promoter:
         TBP   STAT3   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): MYC promoter sequence
   Search SABiosciences Chromatin IP Primers for MYC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.21   Ensembl cytogenetic band:  8q24.21   HGNC cytogenetic band: 8q24

MYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P128748:  view genomic region     (about GC identifiers)

Start:
 128,747,680 bp from pter      End:
 128,753,680 bp from pter
Size:
 6,001 bases      Orientation:
 plus strand

Proteins
for MYC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYC_HUMAN, P01106 (See protein sequence)
Recommended Name: Myc proto-oncogene protein  
Size: 439 amino acids; 48804 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated
at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2 (By similarity). Interacts with NO66
Subcellular location: Nucleus, nucleoplasm. Nucleus, nucleolus
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are
sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem)
cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
5 PDB 3D structures from and Proteopedia for MYC:
1A93 (3D)        1EE4 (3D)        1MV0 (3D)        1NKP (3D)        2A93 (3D)    
Secondary accessions: A8WFE7 P01107 Q14026
Alternative splicing: 2 isoforms:  P01106-1   P01106-2   (Initiates from CTG codon. Ref.7 (BAA01374) sequence is in conflict in positions: 2:D->N, 6:V->E)

Explore the universe of human proteins at neXtProt for MYC: NX_P01106

Post-translational modifications:

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity).
    • Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the
    protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required
    for ubiquitination and degradation by the proteasome1
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the
    • proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7
    (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is
    not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining
    the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01106

    • MYC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002458.2  
    ENSEMBL proteins: 
     ENSP00000259523   ENSP00000429441   ENSP00000367207   ENSP00000430235   ENSP00000430226  
    Reactome Protein details: P01106
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MYC
    OriGene Protein Over-expression Lysate: MYC
    OriGene Custom Protein Services for MYC 
    GenScript Custom Purified and Recombinant Proteins Services for MYC
    Novus Biologicals MYC Proteins
    Novus Biologicals MYC Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MYC
    Uscn Proteins for MYC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15358760
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA17558397
    GO:0005819spindle IEA--
    GO:0043234protein complex IDA17873522


    MYC for ontologies           About GeneDecksing



    MYC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYC
    R&D Systems Antibodies for MYC (c-Myc)
    Cell Signaling Technology (CST) Antibodies for MYC 
    OriGene Antibodies (see all 11): MYC
    OriGene Custom Antibody Services for MYC 
    GenScript Custom Superior Antibodies Services for MYC
    Novus Biologicals MYC Antibodies
    Abcam antibodies for MYC 
    Uscn Antibodies for MYC
    ThermoFisher Antibody for MYC

    Assay Products for MYC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for MYC (c-Myc)
    GenScript Custom Assay Services for MYC
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MYC

    Protein Domains /
    Families
    for MYC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYC for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003327 Myc-LZ
     IPR011598 HLH_dom
     IPR012682 Tscrpt_reg_Myc_N
     IPR002418 Tscrpt_reg_Myc

    Graphical View of Domain Structure for InterPro Entry P01106

    ProtoNet protein and cluster: P01106

    3 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002418 Myc proto-oncogene signature
    IPB003327 Leucine zipper


    UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for MYC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
    Function: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also
    specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes

         Genatlas biochemistry entry for MYC:
    Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various
    cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for
    proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)

    10/1039 SABiosciences Target genes for MYC (see all 1039):
    ABCB11 ABHD12B ACAA2 ACAD8 ACAD9 ACLY ACTL8 ACTR3B ACTR5 ADAMTS17

    miRNA
    Products:            		miRTarBase miRNAs that target MYC:
    hsa-let-7g (MIRT000475), hsa-let-7a (MIRT000417), hsa-mir-378 (MIRT005482), hsa-mir-17 (MIRT005288), hsa-mir-34b (MIRT004401), hsa-mir-145 (MIRT004290), hsa-mir-98 (MIRT003438), hsa-mir-34a (MIRT000695), hsa-mir-24 (MIRT000121), hsa-mir-26a (MIRT003968), hsa-mir-34b (MIRT005319), hsa-mir-34c-5p (MIRT004402), hsa-mir-20a (MIRT005289), hsa-mir-21 (MIRT004307)

    OriGene 3'-UTR Clone: MYC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYC
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MYC:
    hsa-miR-34b* hsa-miR-1294 hsa-miR-1827 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmid: MYC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYC (see all 7)
    OriGene shRNA RFP: MYC
    OriGene siRNA: MYC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYC (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MYC (NM_002467)
    Sino Biological Human cDNA Clone for MYC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYC 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MYC
    Search LifeMap BioReagents cell lines for MYC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYC

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10597290
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9924025
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IPI15674325
    GO:0032403protein complex binding IDA18987311


    MYC for ontologies           About GeneDecksing


    13 GenomeRNAi human phenotypes for MYC:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     G0/1 arrest  Increased G1 DNA content  Increased cell death in DLD-1   Increased cell size 
     Increased viability with TRAIL 

    Animal Models:
         Mouse knock-outs for MYC: Myctm39Mnz Myctm1Lbox Myctm1Brd Myctm1Atp Myctm1.1Dmlo Myctm1Jlc
                                                   Myctm2Dmlo
         15/25 MGI mutant phenotypes (inferred from 21 alleles) (MGI details for Myc) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    MYC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/83 super-pathways (see all 83) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/10 pathways (see all 10)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 in Cancer1.00
    		Signaling by NOTCH0.77
    2NOTCH1 stimulates MYC transcription
    		NOTCH1 stimulates MYC transcription1.00
    		MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex1.00
    		NOTCH1 PEST domain mutants stimulate MYC transcription1.00
    		Notch Pathway0.20
    3Development IGF-RI signaling
    		Development IGF-RI signaling1.00
    		Signal transduction_AKT signaling0.49
    		Development_IGF-1 receptor signaling0.99
    		Signal transduction AKT signaling0.49
    4Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		DNA damage response (only ATM dependent)0.35
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    5Rho Family GTPases
    		ERK Signaling0.61
    		MAPK Signaling0.51
    		Molecular Mechanisms of Cancer0.51
    		ILK Signaling0.45

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for MYC (see all 18)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Meiosis
    Immune response IL-2 activation and signaling pathway
    Development Role of Activin A in cell differentiation and proliferation
    Development PDGF signaling via STATs and NF-kB

    2 R&D Systems Pathways for MYC
        Adipocytokines & Insulin Signaling
    TGF-beta Signaling Pathways

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYC (see all 24)
        MAPK Signaling
    Telomerase Components in Cell Signaling
    Endothelin-1 Signaling Pathway
    IL-10 Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for MYC
        Apoptosis and Autophagy

    1 Tocris Bioscience Pathway for MYC
        Notch Pathway

    5/17 GeneGo (Thomson Reuters) Pathways for MYC (see all 17)
        Development EGFR signaling pathway
    Signal transduction AKT signaling
    Development ERBB-family signaling
    Development PDGF signaling via STATs and NF-kB
    Development EPO-induced Jak-STAT pathway

    5/40 BioSystems Pathways for MYC (see all 40) 
        miRNAs involved in DDR
    ErbB signaling pathway
    TP53 network
    DNA damage response (only ATM dependent)
    p38 MAPK Signaling Pathway

    5/20        Reactome Pathways for MYC (see all 20)
        NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer

    3 PharmGKB Pathways for MYC
        Busulfan Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    5/14         Kegg Pathways  (Kegg details for MYC) (see all 14):
        MAPK signaling pathway
    ErbB signaling pathway
    Cell cycle
    Wnt signaling pathway
    TGF-beta signaling pathway


    MYC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1175 Interacting proteins for MYC (P011061, 2, 3 ENSP000003672074) via UniProtKB, MINT, STRING, and/or I2D (see all 1175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151692, 3, ENSP000002623204MINT-7025816 MINT-7040806 MINT-7025707 MINT-7040758 MINT-7040788 MINT-7025737 MINT-7025765 MINT-7025684 MINT-7040775 MINT-7025780 I2D: score=2 STRING: ENSP00000262320
    MAXP612441, 2, 3, ENSP000003514904EBI-1058440,EBI-878388 MINT-25075 MINT-73406 MINT-73138 I2D: score=15 STRING: ENSP00000351490
    ZBTB17Q131051, 2, 3, ENSP000003648954EBI-1058440,EBI-372156 MINT-7296688 MINT-7296709 I2D: score=7 STRING: ENSP00000364895
    GSK3BP498412, 3, ENSP000003248064MINT-7025816 MINT-7025707 MINT-7025684 I2D: score=4 STRING: ENSP00000324806
    RPL11P629132, 3, ENSP000003636764MINT-5208293 MINT-5208331 MINT-5208311 I2D: score=2 STRING: ENSP00000363676
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9924025
    GO:0000165MAPK cascade IMP17873522
    GO:0001658branching involved in ureteric bud morphogenesis ISS--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--
    GO:0006112energy reserve metabolic process NAS9924025


    MYC for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYC for compounds           About GeneDecksing

    EMD Millipore small molecules for MYC:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MYC

    Browse Tocris compounds for MYC
    10/137 Novoseek chemical compound relationships for MYC gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 61.5 88 9683527 (3), 11306486 (2), 8297793 (2), 11598794 (2) (see all 68)
    retinoic acid 56.9 177 9804832 (5), 9290118 (4), 10984118 (4), 19324018 (4) (see all 67)
    estrogen 55.4 273 15757889 (7), 19398483 (6), 1855215 (6), 8187952 (6) (see all 99)
    tyrosine 54.5 97 7642726 (5), 14634284 (3), 8790838 (3), 11960624 (2) (see all 72)
    thymidine 53.3 55 2187953 (3), 2105952 (2), 1709176 (2), 19149928 (2) (see all 35)
    cb 33 53.3 2 10891489 (1), 11598121 (1)
    12-o-tetradecanoylphorbol 13-acetate 51.4 55 1688464 (3), 10511314 (3), 8518229 (3), 9301678 (2) (see all 27)
    cycloheximide 49.2 46 9624173 (3), 11509750 (3), 17974960 (3), 1995415 (2) (see all 29)
    butyrate 49.1 70 8325387 (6), 8376401 (5), 7558417 (5), 18348176 (4) (see all 30)
    4-hydroxytamoxifen 47.8 13 11369200 (2), 8813114 (1), 18838534 (1), 9892606 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about MYC 

    Transcripts
    for MYC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYC gene: 
    NM_002467.4  

    Unigene Cluster for MYC:

    V-myc myelocytomatosis viral oncogene homolog (avian)
    Hs.202453  [show with all ESTs]
    Unigene Representative Sequence: NM_002467
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259523(uc022bbe.1) ENST00000517291(uc003ysh.1) ENST00000377970(uc003ysi.3)
    ENST00000524013 ENST00000520751

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MYC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYC
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MYC:
    hsa-miR-34b* hsa-miR-1294 hsa-miR-1827 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmid: MYC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYC (see all 7)
    OriGene shRNA RFP: MYC
    OriGene siRNA: MYC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYC (see all 6)
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    GenScript: all cDNA clones in your preferred vector: MYC (NM_002467)
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    Additional cDNA sequence: 

    AK303921.1 AK312883.1 BC000141.1 BC000917.2 BC058901.1 BT019768.1 K02276.1 M13929.1 
    M13930.1 V00568.1 X66258.1 

    17 DOTS entries:

    DT.75165205  DT.100795415  DT.100795410  DT.100795405  DT.95344845  DT.121488939  DT.98131863  DT.100795402 
    DT.100795403  DT.100795413  DT.121488933  DT.92421238  DT.95344846  DT.95344849  DT.100647658  DT.40246397 
    DT.92032502 

    24/246 AceView cDNA sequences (see all 246):

    AI278350 BU186240 BQ632551 BM832775 AA923634 BC058901 BQ436601 BF063312 
    X66258 BG168038 BU181139 BP341647 BF001422 NM_002467 F02958 AA514409 
    CD614917 BC000917 BQ433670 BQ775420 BC000141 BG284635 BE018476 M13929 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MYC    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for MYC

    Expression
    for MYC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCAAATGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic MesodermExtraembryonic Mural CellsExtraembryonic Tissues
    Lateral Plate MesodermSplanchnic MesodermMural CellsPericytes, Smooth Muscle
    Neural CrestCranial Neural CrestCranial Neural Crest CellsNeural Crest
    PancreasVentral Pancreatic BudPancreatic Progenitor CellsPancreas
    Paraxial MesodermParaxial MesodermParaxial Mesoderm CellsMesoderm
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    TestisSeminiferous TubulesSertoli cellsTestis
    BoneCaudal Skull Membranous BonesBone
    BoneRostral Skull Membranous BonesBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line 20D17 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 492B4 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 253G1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS2 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Primordial germ cell-like cells (Reconstitution of mo...)

    See MYC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYC

    SOURCE GeneReport for Unigene cluster: Hs.202453
        SABiosciences Expression via Pathway-Focused PCR Arrays including MYC (see all 27): 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYC

    Orthologs
    for MYC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYC gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Myc1 , 5 myelocytomatosis oncogene1, 5 87.93(n)1
    90.29(a)1    		   15 (26.19 cM)5
    178691  NM_010849.41  NP_034979.31 
     619853915 
    chicken
    (Gallus gallus)    		 Aves MYC1 v-myc myelocytomatosis viral oncogene homolog (avian) 76.07(n)
    72.54(a)    		   420332  NM_001030952.1  NP_001026123.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MYC6
    		 --
    		 68(a)
    		 1 ↔ 1
    		 4(4600382-4605827)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC525952 similar to myelocytomatosis oncogene 79.8(n)    X14806.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii L11710.12   -- 80.41(n)   30686  L11710.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dm6
    		 diminutive
    		 11(a)
    		 possible ortholog
    		 X(3267192-3285730)


    ENSEMBL Gene Tree for MYC (if available)
    TreeFam Gene Tree for MYC (if available) 

    Paralogs
    for MYC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYC gene
    MYCN2  MYCL12  
    4 SIMAP similar genes for MYC using alignment to 57 protein entries:     MYC_HUMAN (see all proteins):
    c-myc    N-myc    MAX    MYCN

    MYC for paralogs           About GeneDecksing



    Genomic Variants
    for MYC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 NCBI SNPs in MYC are shown (see all 166)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs171874281,2
    		C,F,H,--124067857(+) GCGATG/AATCTC 1 -- us2k113Minor allele frequency- A:0.03NA NS EA 1104
    rs46459391,2
    		C,F,--124068190(+) TGGTGG/AAGGGA 1 -- us2k1 trp33Minor allele frequency- A:0.06NS WA 278
    rs46459401,2
    		H--124068215(+) TAAAAT/CGCCTT 1 -- us2k15Minor allele frequency- C:0.00NS EA 574
    rs46459411,2
    		C,F,H,--124068293(+) AAATCC/TCGAGG 1 -- us2k15Minor allele frequency- T:0.00NS EA 568
    rs284616171,2
    		C,--124068525(+) CCCCCC/AAAAAA 1 -- us2k1 trp31Minor allele frequency- A:0.50WA 2
    rs38083791,2
    		C,F,--124068925(-) CCCCCA/GCGCCT 1 -- us2k112Minor allele frequency- G:0.10NS NA WA EA 1158
    rs46459441,2
    		C--124069277(+) TTCCTC/TCTTAT 1 -- us2k1 trp36Minor allele frequency- T:0.00NS MN 570
    rs46459451,2
    		C,F,H,--124069402(+) CCCAGC/GCTTAG 1 -- us2k110Minor allele frequency- G:0.01NS MN EA 986
    rs749151751,2
    		C--124069447(-) CGCCCA/CCCGCC 1 -- us2k10--------
    rs70155371,2
    		C--124069821(+) CTGGAC/TGGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYC (128747680 - 128753680 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for MYC
         5 CNVs: 52371 8615 52372 4609 52370
         1 Inversion: 37296
    Human Gene Mutation Database (HGMD): MYC

    SABiosciences Cancer Mutation PCR Assays
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing MYC:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    WNT Signaling
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYC
    DNA2.0 Custom Variant and Variant Library Synthesis for MYC

    Disorders / Diseases
    for MYC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYC for disorders           About GeneDecksing

    OMIM gene information: 190080   
    OMIM disorders: 113970  
    UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
  • Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors
  • Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
    • Translocation t(8;12)(q24;q22) with BTG1
  • Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant
    • lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal
    aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which
    juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci

    20/253 diseases for MYC (see all 253):    About MalaCards
    burkitt's lymphoma    htlv-1 associated myelopathy/tropical spastic paraparesis    leukemia/lymphoma    htlv-1 associated myelopathy
    lymphoma, large-cell, immunoblastic    primitive neuroectodermal tumor    leukemia    tropical spastic paraparesis
    estrogen-receptor positive breast cancer    bronchiolo-alveolar adenocarcinoma    cerebral primitive neuroectodermal tumor    b-cell non-hodgkin lymphoma
    supratentorial primitive neuroectodermal tumor    mature b-cell neoplasm    superficial spreading melanoma    diffuse large b-cell lymphoma
    neuroectodermal tumors    spastic paraparesis    human t-cell leukemia virus type 1    non-hodgkin lymphoma

    5 diseases from the University of Copenhagen DISEASES database for MYC:
    Lymphoma     Leukemia     Carcinoma     Neuroblastoma
    Retinoblastoma

    10/91 Novoseek disease relationships for MYC gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 84.5 262 7558417 (5), 2307371 (5), 1945409 (5), 10713166 (5) (see all 99)
    tumors 79.7 1799 11526483 (7), 12769686 (6), 17906696 (5), 17664422 (5) (see all 99)
    cancer 72.7 584 18221043 (5), 20065031 (4), 16856965 (4), 18197790 (3) (see all 99)
    retinoblastoma 70.1 83 7609100 (4), 1865909 (2), 8959329 (2), 17251444 (2) (see all 67)
    lymphoma b-cell 68.9 73 12594230 (4), 20442643 (3), 8062825 (2), 11182042 (2) (see all 54)
    lymphoma 68.2 227 11431360 (6), 8919541 (4), 9196434 (4), 2200538 (4) (see all 99)
    myeloid leukemia 66.5 28 7500645 (2), 8810318 (1), 1901940 (1), 16185479 (1) (see all 24)
    breast cancer 65.3 326 17052904 (5), 11948489 (4), 15757889 (4), 16202165 (4) (see all 99)
    leukemia 64.8 157 16855632 (5), 7739203 (5), 11734062 (4), 8260894 (3) (see all 93)
    medulloblastoma 64.6 85 18059365 (7), 16724266 (5), 16423996 (5), 12941792 (4) (see all 32)

    Genatlas disease: MYC
    Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations
    t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

    Genetic Association Database (GAD): MYC
    Human Genome Epidemiology (HuGE) Navigator: MYC (73 documents)
    Tumor Gene Database (TGDB): MYC

    Export disorders for MYC gene to outside databases

    Publications
    for MYC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYC gene, integrated from 9 sources (see all 4054):
    (articles sorted by number of sources associating them with MYC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Six lysine residues on c-Myc are direct substrates for acetylation by p300. (PubMed id 16126174)1, 2, 9 Zhang K.... Martinez E. (2005)
    2. Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. (PubMed id 9680483)1, 2, 9 Lavigne P.... Sykes B.D. (1998)
    3. c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. (PubMed id 11182042)1, 4, 9 Hiyama T....Chayama K. (2001)
    4. Phosphorylation by Cdk2 is required for Myc to repres s Ras-induced senescence in cotransformation. (PubMed id 19966300)1, 2, 9 Hydbring P....Larsson L.G. (2010)
    5. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. (PubMed id 17308053)1, 2, 9 Suzuki C....Daigo Y. (2007)
    6. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. (PubMed id 1597196)1, 2, 9 Iijima S.... Tsukada K. (1992)
    7. DYRK2 priming phosphorylation of c-Jun and c-Myc modul ates cell cycle progression in human cancer cells. (PubMed id 22307329)1, 2 Taira N....Yoshida K. (2012)
    8. Myc protein is stabilized by suppression of a novel E 3 ligase complex in cancer cells. (PubMed id 20551172)1, 2 Choi S.H....Cole M.D. (2010)
    9. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. (PubMed id 17873522)1, 2 Popov N....Eilers M. (2007)
    10. The ubiquitin-specific protease USP28 is required for MYC stability. (PubMed id 17558397)1, 2 Popov N....Eilers M. (2007)

    External Searches for MYC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MYC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4609 HGNC: 7553 AceView: MYC Ensembl:ENSG00000136997 euGenes: HUgn4609
    ECgene: MYC Kegg: 4609 H-InvDB: MYC

    Other Databases showing MYC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYC Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/myc/
    Wikipedia http://en.wikipedia.org/wiki/Myc

    Intellectual Property
    for MYC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYC gene:
    Search GeneIP for patents involving MYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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