Aliases for MYC Gene
External Ids for MYC Gene
Previous GeneCards Identifiers for MYC Gene
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYC Gene
MYC (V-Myc Avian Myelocytomatosis Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and Myoclonus, Familial Cortical. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYCN.
UniProtKB/Swiss-Prot for MYC Gene
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.