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MYC Gene

protein-coding   GIFtS: 75
GCID: GC08P128748

V-Myc Avian Myelocytomatosis Viral Oncogene Homolog

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Myc Avian Myelocytomatosis Viral Oncogene Homolog1 2     Avian Myelocytomatosis Viral Oncogene Homolog2
Class E Basic Helix-Loop-Helix Protein 392 3     c-Myc2
Proto-Oncogene C-Myc2 3     Myc Proto-Oncogene Protein2
Transcription Factor P642 3     Myc-Related Translation/Localization Regulatory Factor2
bHLHe392 3     V-Myc Myelocytomatosis Viral Oncogene Homolog2
MRTL2     BHLHE393
MYCC2     

External Ids:    HGNC: 75531   Entrez Gene: 46092   Ensembl: ENSG000001369977   OMIM: 1900805   UniProtKB: P011063   

Export aliases for MYC gene to outside databases

Previous GC identifers: GC08P127757 GC08P128836 GC08P128419 GC08P128705 GC08P128817 GC08P124069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYC Gene:
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle
progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates
transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene
have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.
There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a
downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of
non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function
of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYC Gene:
MYC (v-myc avian myelocytomatosis viral oncogene homolog) is a protein-coding gene. Diseases associated with MYC include burkitt's lymphoma, and vulva basal cell carcinoma. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYCL.

UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
Function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core
sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes

Gene Wiki entry for MYC (Myc) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYC gene promoter:
         TBP   STAT3   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): MYC promoter sequence
   Search Chromatin IP Primers for MYC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.21   Ensembl cytogenetic band:  8q24.21   HGNC cytogenetic band: 8q24

MYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P128748:  view genomic region     (about GC identifiers)

Start:
128,747,680 bp from pter      End:
128,753,680 bp from pter
Size:
6,001 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MYC_HUMAN, P01106 (See protein sequence)
Recommended Name: Myc proto-oncogene protein  
Size: 439 amino acids; 48804 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when
phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66. The heterodimer
MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors
are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent
stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
6 PDB 3D structures from and Proteopedia for MYC:
1A93 (3D)        1EE4 (3D)        1MV0 (3D)        1NKP (3D)        2A93 (3D)        2OR9 (3D)    
Secondary accessions: A8WFE7 P01107 Q14026
Alternative splicing: 2 isoforms:  P01106-1   P01106-2   (Initiates from CTG codon. Ref.7 (BAA01374) sequence is in conflict in positions: 2:D->N, 6:V->E)

Explore the universe of human proteins at neXtProt for MYC: NX_P01106

Explore proteomics data for MYC at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity).
    Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes
    the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is
    required for ubiquitination and degradation by the proteasome1
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by
    the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of
    FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however,
    ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7
    (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the
    DCX(TRUSS) complex1
  • Ubiquitination2 at Lys148, Lys389
  • Glycosylation2 at Thr58
  • Modification sites at PhosphoSitePlus

  • See MYC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002458.2  
    ENSEMBL proteins: 
     ENSP00000259523   ENSP00000429441   ENSP00000367207   ENSP00000430235   ENSP00000430226  
    Reactome Protein details: P01106

    MYC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MYC
    OriGene Protein Over-expression Lysate for MYC
    OriGene MassSpec for MYC
    OriGene Custom Protein Services for MYC
    GenScript Custom Purified and Recombinant Proteins Services for MYC
    Novus Biologicals MYC Proteins
    Novus Biologicals MYC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MYC
    Cloud-Clone Corp. Proteins for MYC

    MYC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYC
    R&D Systems Antibodies for MYC (c-Myc)
    Cell Signaling Technology (CST) Antibodies for MYC 
    OriGene Antibodies for MYC
    OriGene Custom Antibody Services for MYC
    Novus Biologicals MYC Antibodies
    Abcam antibodies for MYC
    Cloud-Clone Corp. Antibodies for MYC
    ThermoFisher Antibody for MYC
    LSBio Antibodies in human, mouse, rat for MYC

    MYC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYC
    Cloud-Clone Corp. CLIAs for MYC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    4 InterPro protein domains:
     IPR012682 Tscrpt_reg_Myc_N
     IPR003327 Myc-LZ
     IPR011598 bHLH_dom
     IPR002418 Tscrpt_reg_Myc

    Graphical View of Domain Structure for InterPro Entry P01106

    ProtoNet protein and cluster: P01106

    3 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002418 Myc proto-oncogene signature
    IPB003327 Leucine zipper


    UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MYC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYC_HUMAN, P01106
    Function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core
    sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes

         Genatlas biochemistry entry for MYC:
    Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various
    cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for
    proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell
    lymphoma)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10597290
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9924025
    GO:0005515protein binding IPI10597290
    GO:0008134transcription factor binding IPI15674325
    GO:0032403protein complex binding IDA18987311
         
    MYC for ontologies           About GeneDecksing


    Phenotypes:
         13 GenomeRNAi human phenotypes for MYC:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     G0/1 arrest  Increased G1 DNA content  Increased cell death in DLD-1   Increased cell size 
     Increased viability with TRAIL 

         Selected MGI mutant phenotypes (inferred from 21 alleles(MGI details for Myc) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    MYC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYC: Myctm39Mnz Myctm1Atp Myctm1Lbox Myctm1Brd Myctm1.1Dmlo Myctm1Jlc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYC

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MYC (see all 1007):
    ABCB11,  ABHD12B,  ACAA2,  ACAD8,  ACAD9,  ACLY,  ACTL8,  ACTR3B,  ACTR5,  ADAMTS17

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GNCCACGTGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYC:
    hsa-let-7b-5p (MIRT052217), hsa-mir-451a (MIRT006358), hsa-let-7g-5p (MIRT000475), hsa-mir-378a-3p (MIRT005482), hsa-mir-17-5p (MIRT005288), hsa-mir-145-5p (MIRT004290), hsa-mir-429 (MIRT016647), hsa-mir-98-5p (MIRT003438), hsa-mir-34a-5p (MIRT000695), hsa-mir-24-3p (MIRT000121), hsa-mir-26a-5p (MIRT003968), hsa-mir-21-5p (MIRT004307), hsa-mir-335-5p (MIRT017925), hsa-let-7a-5p (MIRT000417), hsa-let-7f-5p (MIRT032089), hsa-mir-135a-5p (MIRT007105), hsa-let-7c-5p (MIRT003748), hsa-mir-34b-5p (MIRT004401), hsa-mir-320a (MIRT044759), hsa-mir-423-5p (MIRT038140), hsa-mir-320b (MIRT036232), hsa-mir-744-5p (MIRT037690), hsa-mir-34c-5p (MIRT004402), hsa-mir-34b-3p (MIRT005319), hsa-mir-449c-5p (MIRT007308), hsa-mir-20a-5p (MIRT005289)

    Block miRNA regulation of human, mouse, rat MYC using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MYC:
    hsa-miR-34b* hsa-miR-1294 hsa-miR-1827 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidMYC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYC
    Predesigned siRNA for gene silencing in human, mouse, rat MYC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYC

    Clone
    Products:
         
    OriGene clones in human, mouse for MYC (see all 9)
    OriGene ORF clones in mouse, rat for MYC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYC (NM_002467)
    Sino Biological Human cDNA Clone for MYC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYC
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYC_HUMAN, P01106: Nucleus, nucleoplasm. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    mitochondrion2
    cytosol1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11793365
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA17558397
    GO:0005819spindle IEA--
    GO:0043234protein complex IDA17873522

    MYC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYC About   (see all 103)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    Development ERBB family signaling0.57
    4E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for MYC
        Adipocytokines & Insulin Signaling
    Akt Signaling Pathway
    Notch Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYC (see all 24)
        MAPK Signaling
    Telomerase Components in Cell Signaling
    Endothelin-1 Signaling Pathway
    IL-10 Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for MYC
        Apoptosis and Autophagy

    1 Tocris Bioscience Pathway for MYC
        Notch Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MYC (see all 17)
        Development EGFR signaling pathway
    Signal transduction AKT signaling
    Development ERBB-family signaling
    Development PDGF signaling via STATs and NF-kB
    Development EPO-induced Jak-STAT pathway

    Selected BioSystems Pathways for MYC (see all 45)
        MAPK signaling pathway
    Apoptosis
    DNA damage response
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway


    Selected Reactome Pathways for MYC (see all 7)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Cyclin A:Cdk2-associated events at S phase entry
    Cyclin E associated events during G1/S transition
    binding of TCF/LEF:CTNNB1 to target gene promoters

    3 PharmGKB Pathways for MYC
        Busulfan Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MYC) (see all 23):
        MAPK signaling pathway
    ErbB signaling pathway
    Cell cycle
    PI3K-Akt signaling pathway
    Wnt signaling pathway


    MYC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYC (see all 27): 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYC (P011061, 2, 3 ENSP000003672074) via UniProtKB, MINT, STRING, and/or I2D (see all 1237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3, ENSP000002623204EBI-447544,EBI-710484 MINT-7025816 MINT-7040806 MINT-7025707 MINT-7040758 MINT-7040788 MINT-7025737 MINT-7025765 MINT-7025684 MINT-7040775 MINT-7025780 I2D: score=2 STRING: ENSP00000262320
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9924025
    GO:0000165MAPK cascade IMP17873522
    GO:0001658branching involved in ureteric bud morphogenesis ISS--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--
    GO:0006112energy reserve metabolic process NAS9924025

    MYC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MYC
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYC

    Selected Novoseek inferred chemical compound relationships for MYC gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 61.5 88 9683527 (3), 11306486 (2), 8297793 (2), 11598794 (2) (see all 68)
    retinoic acid 56.9 177 9804832 (5), 9290118 (4), 10984118 (4), 19324018 (4) (see all 67)
    estrogen 55.4 273 15757889 (7), 19398483 (6), 1855215 (6), 8187952 (6) (see all 99)
    tyrosine 54.5 97 7642726 (5), 14634284 (3), 8790838 (3), 11960624 (2) (see all 72)
    thymidine 53.3 55 2187953 (3), 2105952 (2), 1709176 (2), 19149928 (2) (see all 35)
    cb 33 53.3 2 10891489 (1), 11598121 (1)
    12-o-tetradecanoylphorbol 13-acetate 51.4 55 1688464 (3), 10511314 (3), 8518229 (3), 9301678 (2) (see all 27)
    cycloheximide 49.2 46 9624173 (3), 11509750 (3), 17974960 (3), 1995415 (2) (see all 29)
    butyrate 49.1 70 8325387 (6), 8376401 (5), 7558417 (5), 18348176 (4) (see all 30)
    4-hydroxytamoxifen 47.8 13 11369200 (2), 8813114 (1), 18838534 (1), 9892606 (1) (see all 9)



    MYC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYC gene: 
    NM_002467.4  

    Unigene Cluster for MYC:

    V-myc myelocytomatosis viral oncogene homolog (avian)
    Hs.202453  [show with all ESTs]
    Unigene Representative Sequence: NM_002467
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259523(uc022bbe.1) ENST00000517291(uc003ysh.1) ENST00000377970(uc003ysi.3)
    ENST00000524013 ENST00000520751
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYC using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MYC:
    hsa-miR-34b* hsa-miR-1294 hsa-miR-1827 hsa-miR-449c
    SwitchGear 3'UTR luciferase reporter plasmidMYC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYC
    Predesigned siRNA for gene silencing in human, mouse, rat MYC
    Clone
    Products:
         
    OriGene clones in human, mouse for MYC (see all 9)
    OriGene ORF clones in mouse, rat for MYC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYC (NM_002467)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYC
    Primer
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    OriGene qPCR primer pairs and template standards for MYC
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    Additional mRNA sequence: 

    AK303921.1 AK312883.1 BC000141.1 BC000917.2 BC058901.1 BT019768.1 K02276.1 M13929.1 
    M13930.1 V00568.1 X66258.1 

    17 DOTS entries:

    DT.75165205  DT.100795415  DT.100795410  DT.100795405  DT.95344845  DT.121488939  DT.98131863  DT.100795402 
    DT.100795403  DT.100795413  DT.121488933  DT.92421238  DT.95344846  DT.95344849  DT.100647658  DT.40246397 
    DT.92032502 

    Selected AceView cDNA sequences (see all 246):

    BC000141 BF001422 BQ433670 BQ775420 CD614917 NM_002467 F02958 BM742710 
    BQ436601 BX110338 BF063312 CA454569 BU181139 BX421406 CK431139 AI864891 
    CR609560 M13930 CA446124 BC058901 AI538453 AW675223 BQ632551 BQ225726 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MYC    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for MYC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAATGCA
    MYC Expression
    About this image


    MYC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             20D17
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Caudal Skull Membranous Bones
     
     Thymus (Hematopoietic System)
             Thymus
     
     Smooth Muscle (Muscoskeletal System)
             Mural Cells Splanchnic Mesoderm
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
    MYC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202453
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYC (see all 27): 
              Stem Cell Transcription Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYC gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myc1 , 5 myelocytomatosis oncogene1, 5 87.49(n)1
    89.62(a)1
      15 (26.19 cM)5
    178691  NM_010849.41  NP_034979.31 
     619853915 
    chicken
    (Gallus gallus)
    Aves MYC1 v-myc myelocytomatosis viral oncogene homolog 75.9(n)
    72.54(a)
      420332  NM_001030952.1  NP_001026123.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYC6
    v-myc avian myelocytomatosis viral oncogene homolo...
    63(a)
    1 ↔ 1
    4(4599220-4610850)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525952 similar to myelocytomatosis oncogene 79.8(n)    X14806.1 
    zebrafish
    (Danio rerio)
    Actinopterygii L11710.12   -- 80.41(n)   30686  L11710.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dm6
    diminutive
    13(a)
    1 → many
    X(3267192-3285730)


    ENSEMBL Gene Tree for MYC (if available)
    TreeFam Gene Tree for MYC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYC gene
    MYCL2  MYCN2  
    4 SIMAP similar genes for MYC using alignment to 57 protein entries:     MYC_HUMAN (see all proteins):
    c-myc    N-myc    MAX    MYCN

    MYC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYC (see all 207)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0633854
    A Burkitt lymphoma sample4--see VAR_0633852 P S mis40--------
    VAR_0633864
    A Burkitt lymphoma sample4--see VAR_0633862 P A mis40--------
    VAR_0633844
    A Burkitt lymphoma symple4--see VAR_0633842 E D mis40--------
    VAR_0633874
    A Burkitt lymphoma sample4--see VAR_0633872 N T mis40--------
    rs46459421,2
    C--128747258(+) ACCCCC/-TGCCC 1 -- us2k11Minor allele frequency- -:0.01NS 158
    rs107068411,2
    C--128751847(+) TGGACT/-TTTTT 1 -- int1 trp32Minor allele frequency- -:0.25NA 4
    rs58948981,2
    C,F--128751903(+) TGCAA-/T/TT  
            
    TTTTT
    1 -- int1 trp32NA 4
    rs171874281,2
    C,F,H--129007561(+) GCGATG/AATCTC 1 -- us2k113Minor allele frequency- A:0.03NA NS EA 1104
    rs1460325271,2
    --129007769(+) GAAGCC/TACTAT 1 -- us2k10--------
    rs1171348521,2
    F--129007789(+) ACACTT/CGAACG 1 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for MYC (128747680 - 128753680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831458CNV Loss17160897
    esv2752208CNV Gain17911159
    nsv516713CNV Gain+Loss19592680
    nsv499795OTHER Inversion21111241
    nsv7419OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): MYC
    Site Specific Mutation Identification with PCR Assays
    4 Copy Number PCR Panels containing MYC:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing MYC
    DNA2.0 Custom Variant and Variant Library Synthesis for MYC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 190080   
    OMIM disorders: 113970  
    UniProtKB/Swiss-Prot: MYC_HUMAN, P01106
  • Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors
  • Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic
    leukemia. Translocation t(8;12)(q24;q22) with BTG1
  • Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as
    a large osteolytic lesion in the jaw or as an abdominal mass. Note=The gene represented in this entry is involved
    in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma.
    Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin
    gene loci

  • Selected diseases for MYC (see all 230):    
    About MalaCards
    burkitt's lymphoma    vulva basal cell carcinoma    uterine corpus cancer    mature b-cell neoplasm
    endocervical carcinoma    endocervicitis    sinus cancer    sclerosing adenosis of breast
    maxillary sinus cancer    bronchiolo-alveolar adenocarcinoma    diffuse large b-cell lymphoma    diffuse large b-cell lymphoma of the central nervous system
    chromosome 17p deletion    lymphoma, large-cell, immunoblastic    myoclonus, familial cortical    cerebral primitive neuroectodermal tumor
    primitive neuroectodermal tumor    medullomyoblastoma    hepatic angiomyolipoma    hereditary multiple exostoses

    6 diseases from the University of Copenhagen DISEASES database for MYC:
    Lymphoma     Leukemia     Carcinoma     Retinoblastoma
    Neuroblastoma     Lung cancer

    MYC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MYC gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 84.5 262 7558417 (5), 2307371 (5), 1945409 (5), 10713166 (5) (see all 99)
    tumors 79.7 1799 11526483 (7), 12769686 (6), 17906696 (5), 17664422 (5) (see all 99)
    cancer 72.7 584 18221043 (5), 20065031 (4), 16856965 (4), 18197790 (3) (see all 99)
    retinoblastoma 70.1 83 7609100 (4), 1865909 (2), 8959329 (2), 17251444 (2) (see all 67)
    lymphoma b-cell 68.9 73 12594230 (4), 20442643 (3), 8062825 (2), 11182042 (2) (see all 54)
    lymphoma 68.2 227 11431360 (6), 8919541 (4), 9196434 (4), 2200538 (4) (see all 99)
    myeloid leukemia 66.5 28 7500645 (2), 8810318 (1), 1901940 (1), 16185479 (1) (see all 24)
    breast cancer 65.3 326 17052904 (5), 11948489 (4), 15757889 (4), 16202165 (4) (see all 99)
    leukemia 64.8 157 16855632 (5), 7739203 (5), 11734062 (4), 8260894 (3) (see all 93)
    medulloblastoma 64.6 85 18059365 (7), 16724266 (5), 16423996 (5), 12941792 (4) (see all 32)

    Genatlas disease: MYC
    Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations
    t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

    Genetic Association Database (GAD): MYC
    Human Genome Epidemiology (HuGE) Navigator: MYC (73 documents)
    Tumor Gene Database (TGDB): MYC

    Export disorders for MYC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYC gene, integrated from 10 sources (see all 4193):
    (articles sorted by number of sources associating them with MYC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. (PubMed id 20087644)1, 4, 9 Fernberg P....EkstrAPm Smedby K. (amp 2010)
    2. Six lysine residues on c-Myc are direct substrates for acetylation by p300. (PubMed id 16126174)1, 2, 9 Zhang K.... Martinez E. (Biochem. Biophys. Res. Commun. 2005)
    3. Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. (PubMed id 9680483)1, 2, 9 Lavigne P.... Sykes B.D. (J. Mol. Biol. 1998)
    4. c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. (PubMed id 11182042)1, 4, 9 Hiyama T....Chayama K. (Oncol. Rep. 2001)
    5. Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. (PubMed id 19966300)1, 2, 9 Hydbring P.... Larsson L.-G. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4, 9 Jardin F....Tilly H. (Br. J. Haematol. 2009)
    7. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 4, 9 Morton L.M....Hartge P. (amp 2009)
    8. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. (PubMed id 17308053)1, 2, 9 Suzuki C.... Daigo Y. (Mol. Cancer Ther. 2007)
    9. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. (PubMed id 1597196)1, 2, 9 Iijima S.... Tsukada K. (Eur. J. Biochem. 1992)
    10. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PubMed id 22307329)1, 2 Taira N....Yoshida K. (J. Clin. Invest. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4609 HGNC: 7553 AceView: MYC Ensembl:ENSG00000136997 euGenes: HUgn4609
    ECgene: MYC Kegg: 4609 H-InvDB: MYC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYC Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/myc/
    Wikipedia http://en.wikipedia.org/wiki/Myc

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYC gene:
    Search GeneIP for patents involving MYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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