MYBPHL Gene
protein-coding GIFtS: 37
GCID: GC01M109834
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myosin binding protein H-like
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Aliases
for MYBPHL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin Binding Protein H-Like1 2 | | Myosin-Binding Protein H-Like2 |
Export aliases for MYBPHL gene to outside databasesPrevious GC identifers: GC01M109548 GC01M109623 GC01M109636 GC01M107728 |
Summaries
for MYBPHL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYBPHL:
This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternativesplicing results in multiple transcript variants. (provided by RefSeq, May 2012)
|
Genomic Views
for MYBPHL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYBPHL gene promoter:
E2F-4 E2F-3a E2F-5 p300 E2F-2 FOXL1 CHOP-10 E2F E2F-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYBPHL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYBPHL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13MYBPHL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M109834: view genomic region
(about GC identifiers)
Start:
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109,834,987 bp from pter |
End:
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109,849,663 bp from pter |
Size:
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14,677 bases |
Orientation:
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minus strand |
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Proteins
for MYBPHL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MBPHL_HUMAN, A2RUH7 (See
protein sequence)Recommended Name: Myosin-binding protein H-like Size: 354 amino acids; 38733 Da
Secondary accessions: Q5T2Z7Explore the universe of human proteins at neXtProt for MYBPHL: NX_A2RUH7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2RUH7
MYBPHL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010985.2 NP_001252542.1
ENSEMBL proteins: ENSP00000349678
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MYBPHL for ontologies About GeneDecksing
MYBPHL Antibody Products:
Assay Products for MYBPHL: |
Protein
Domains /
Families
for MYBPHL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYBPHL for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry A2RUH7ProtoNet protein and cluster: A2RUH7 UniProtKB/Swiss-Prot: MBPHL_HUMAN, A2RUH7Similarity: Belongs to the immunoglobulin superfamily. MyBP familySimilarity: Contains 1 fibronectin type-III domainSimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for MYBPHL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MYBPHL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBPHL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBPHL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MYBPHL for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MYBPHL:
|
Pathways & Interactions
for MYBPHL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYBPHL
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MYBPHL for ontologies About GeneDecksing
|
Drugs & Compounds
for MYBPHL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MYBPHL
Search CenterWatch for drugs/clinical trials and news about MYBPHL / MBPHL
|
Transcripts
for MYBPHL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYBPHL gene (2 alternative transcripts): NM_001010985.2 NM_001265613.1 Unigene Cluster for MYBPHL: Myosin binding protein H-like Hs.443402 [show with all ESTs]Unigene Representative Sequence: AK1298343 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489706 ENST00000357155(uc001dxk.1 uc010ovh.1) ENST00000477962(uc001dxl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYBPHL (NM_001010985) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYBPHL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBPHL |
Additional cDNA sequence: AK129834.1 BC108664.1 BC132900.1 BC132902.1 BC144471.1 5 DOTS entries: DT.101977531 DT.97806505 DT.406383 DT.97772043 DT.99962451 15 AceView cDNA sequences: BX280558 BX092390 AW015331 BQ423879 AA351121 BV180601 AK129834 BV206910 BQ434565 H79798 AA973904 AA419195 AA410639 AW151824 BM929701
GeneLoc Exon Structure
|
Expression
for MYBPHL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYBPHL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGGTTTGG
About this image
See MYBPHL Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.443402
SABiosciences Custom PCR Arrays for MYBPHL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYBPHL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYBPHL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYBPHL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYBPHL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBPHL |
Orthologs
for MYBPHL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYBPHL gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
39(a) |
1 → many |
26(993790-1003624) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
41(a) |
1 → many |
4(133145131-133170766) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC645882 |
hypothetical protein MGC64588 |
72.76(n) |
|
BC044328.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:660976zgc:1653446 |
zgc:165344 |
35(a)34(a) |
many ↔ manymany ↔ many |
23(6128316-6176816) 6(55005416-55052177) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG149646 |
-- |
5(a) |
1 → many |
3L(3172817-3178580) |
ENSEMBL Gene Tree for MYBPHL (if available)
TreeFam Gene Tree for MYBPHL (if available) |
Paralogs
for MYBPHL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYBPHL gene
- MYOM12 MYBPH2 IGSF222 IGFN12 MYBPC22 MYBPC12 MYBPC32 MYOM32
- MYOM22
5 SIMAP similar genes for MYBPHL using alignment to 2 protein entries: MBPHL_HUMAN (see all proteins):MYBPH MYBPC2 MYBPC3 MYBPC1 K-SAM
MYBPHL for paralogs About GeneDecksing
|
Genomic Variants
for MYBPHL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYBPHL (109834987 - 109849663 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYBPHL: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MYBPHL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MYBPHL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYBPHL gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYBPHL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MYBPHL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MYBPHL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYBPHL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYBPHL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MYBPHL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MYBPHL gene:
Search GeneIP for patents involving MYBPHL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYBPHL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYBPHL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYBPHL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYBPHL | | | OriGene Protein Over-expression Lysate for MYBPHL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYBPHL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYBPHL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MYBPHL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBPHL |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBPHL |
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