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Aliases for MYBPH Gene

Aliases for MYBPH Gene

  • Myosin Binding Protein H 2 3
  • Myosin-Binding Protein H 2 3
  • H-Protein 3 4
  • MyBP-H 3 4

External Ids for MYBPH Gene

Previous GeneCards Identifiers for MYBPH Gene

  • GC01M200820
  • GC01M198566
  • GC01M199603
  • GC01M200425
  • GC01M199868
  • GC01M201403
  • GC01M174302

Summaries for MYBPH Gene

GeneCards Summary for MYBPH Gene

MYBPH (Myosin Binding Protein H) is a Protein Coding gene. Diseases associated with MYBPH include measles. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G13 Signaling Pathway. GO annotations related to this gene include structural constituent of muscle. An important paralog of this gene is MYBPC2.

UniProtKB/Swiss-Prot for MYBPH Gene

  • Binds to myosin; probably involved in interaction with thick myofilaments in the A-band

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBPH Gene

Genomics for MYBPH Gene

Regulatory Elements for MYBPH Gene

Genomic Location for MYBPH Gene

Start:
203,167,811 bp from pter
End:
203,175,840 bp from pter
Size:
8,030 bases
Orientation:
Minus strand

Genomic View for MYBPH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYBPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBPH Gene

Proteins for MYBPH Gene

  • Protein details for MYBPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13203-MYBPH_HUMAN
    Recommended name:
    Myosin-binding protein H
    Protein Accession:
    Q13203
    Secondary Accessions:
    • Q16886
    • Q86YC5

    Protein attributes for MYBPH Gene

    Size:
    477 amino acids
    Molecular mass:
    52050 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYBPH Gene

Proteomics data for MYBPH Gene at MOPED

Post-translational modifications for MYBPH Gene

  • Ubiquitination at Lys427
  • Modification sites at PhosphoSitePlus

Other Protein References for MYBPH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYBPH Gene

Domains for MYBPH Gene

Gene Families for MYBPH Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • MYBP :Myosin binding proteins

Suggested Antigen Peptide Sequences for MYBPH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13203

UniProtKB/Swiss-Prot:

MYBPH_HUMAN :
  • Q13203
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. MyBP family.
genes like me logo Genes that share domains with MYBPH: view

Function for MYBPH Gene

Molecular function for MYBPH Gene

GENATLAS Biochemistry: myosin binding protein H
UniProtKB/Swiss-Prot Function: Binds to myosin; probably involved in interaction with thick myofilaments in the A-band

Gene Ontology (GO) - Molecular Function for MYBPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22085929
GO:0008307 structural constituent of muscle TAS 8486381
genes like me logo Genes that share ontologies with MYBPH: view

Phenotypes for MYBPH Gene

GenomeRNAi human phenotypes for MYBPH:
genes like me logo Genes that share phenotypes with MYBPH: view

Animal Model Products

CRISPR Products

miRNA for MYBPH Gene

miRTarBase miRNAs that target MYBPH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYBPH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYBPH Gene

Localization for MYBPH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYBPH Gene COMPARTMENTS Subcellular localization image for MYBPH gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MYBPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYBPH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYBPH Gene

Pathways for MYBPH Gene

genes like me logo Genes that share pathways with MYBPH: view

Pathways by source for MYBPH Gene

1 Qiagen pathway for MYBPH Gene
1 BioSystems pathway for MYBPH Gene

Gene Ontology (GO) - Biological Process for MYBPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006942 regulation of striated muscle contraction TAS 8486381
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MYBPH: view

Compounds for MYBPH Gene

(1) PharmGKB related drug/compound annotations for MYBPH Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with MYBPH: view

Transcripts for MYBPH Gene

mRNA/cDNA for MYBPH Gene

Unigene Clusters for MYBPH Gene

Myosin binding protein H:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYBPH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYBPH Gene

No ASD Table

Relevant External Links for MYBPH Gene

GeneLoc Exon Structure for
MYBPH
ECgene alternative splicing isoforms for
MYBPH

Expression for MYBPH Gene

mRNA expression in normal human tissues for MYBPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYBPH Gene

This gene is overexpressed in Muscle - Skeletal (29.0) and Minor Salivary Gland (14.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYBPH Gene

SOURCE GeneReport for Unigene cluster for MYBPH Gene Hs.927

mRNA Expression by UniProt/SwissProt for MYBPH Gene

Q13203-MYBPH_HUMAN
Tissue specificity: Skeletal muscle
genes like me logo Genes that share expressions with MYBPH: view

In Situ Assay Products

Orthologs for MYBPH Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYBPH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBPH 35
  • 99.16 (n)
  • 98.11 (a)
MYBPH 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYBPH 35
  • 85.95 (n)
  • 82.39 (a)
MYBPH 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYBPH 35
  • 85.39 (n)
  • 83.62 (a)
MYBPH 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybph 35
  • 85.95 (n)
  • 85.95 (a)
Mybph 16
Mybph 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBPH 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mybph 35
  • 82.53 (n)
  • 81.13 (a)
chicken
(Gallus gallus)
Aves MYBPH 35
  • 66.35 (n)
  • 58.16 (a)
MYBPH 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mybph 35
  • 57.81 (n)
  • 56.86 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mybpha 35
  • 58.15 (n)
  • 52.38 (a)
mybpha 36
  • 46 (a)
ManyToMany
mybphb 36
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for MYBPH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBPH Gene

ENSEMBL:
Gene Tree for MYBPH (if available)
TreeFam:
Gene Tree for MYBPH (if available)

Paralogs for MYBPH Gene

Paralogs for MYBPH Gene

Selected SIMAP similar genes for MYBPH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYBPH: view

Variants for MYBPH Gene

Sequence variations from dbSNP and Humsavar for MYBPH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs762625 -- 203,176,173(-) GCCCC(A/G)TAGAC upstream-variant-2KB
rs883125 -- 203,177,038(+) agcaa(C/G)ttcag upstream-variant-2KB
rs903359 -- 203,177,621(-) GATCC(A/C)GTCTC upstream-variant-2KB
rs2071013 -- 203,176,092(-) TGGCA(C/T)GCGGC upstream-variant-2KB
rs2250509 -- 203,169,842(-) TGACC(C/T)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYBPH Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897

Relevant External Links for MYBPH Gene

HapMap Linkage Disequilibrium report
MYBPH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBPH Gene

Disorders for MYBPH Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYBPH Gene including...

Search for MYBPH Gene in MalaCards »

(2) Novoseek inferred disease relationships for MYBPH Gene

Disease -log(P) Hits PubMed IDs
measles 45.2 1
prolapse 38.9 5

Relevant External Links for MYBPH

Genetic Association Database (GAD)
MYBPH
Human Genome Epidemiology (HuGE) Navigator
MYBPH
genes like me logo Genes that share disorders with MYBPH: view

No data available for UniProtKB/Swiss-Prot for MYBPH Gene

Publications for MYBPH Gene

  1. Human myosin-binding protein H (MyBP-H): complete primary sequence, genomic organization, and chromosomal localization. (PMID: 8486381) Vaughan K.T. … Fischman D.A. (Genomics 1993) 2 3 4 23
  2. Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C. (PMID: 10024460) Gruen M. … Gautel M. (J. Mol. Biol. 1999) 3 23
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for MYBPH Gene

Sources for MYBPH Gene

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