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MYBPC3 Gene

protein-coding GIFtS: 62

GC11M047309

myosin binding protein C, cardiac
(Previous names: myosin-binding protein C, cardiac )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMH4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CMH4 ^², ⁵
DKFZp779E1762 ^²
FHC ^¹, ²
MYBP-C ^¹, ²

Descriptions
C-protein, cardiac muscle isoform ^³
Cardiac MyBP-C ^³
myosin binding protein C, cardiac ^²
myosin-binding protein C, cardiac ^¹, ²

External Ids
HGNC: 7551¹
Entrez Gene: 4607²
UniProtKB: Q14896³
Ensembl: ENSG00000134571⁷

Search outside databases for aliases for MYBPC3 gene

Previous GC identifers: GC11M049292 GC11M048230 GC11M047384 GC11M047317

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MYBPC3:

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a

myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated

muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory

phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon

adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are

one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq]

UniProtKB/Swiss-Prot: MYPC3_HUMAN, Q14896

Function: Thick filament-associated protein located in the crossbridge region of vertebrate

striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies

the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a

more structural role

Gene Wiki entry for MYBPC3 (Myosin_binding_protein_C%2C_cardiac)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYBPC3 gene

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

MYBPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M047309: (about GC identifiers)

Start:	47,309,533 bp from pter
End:	47,330,829 bp from pter
Size:	21,297 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MYPC3_HUMAN, Q14896 (See protein sequence)

Recommended Name: Myosin-binding protein C, cardiac-type

Size: 1273 amino acids; 140606 Da

PDB structures from and Proteopedia :

1GXE (3D)

1PD6 (3D)

2AVG (3D)

2K1M (3D)

2V6H (3D)

3CX2 (3D)

Secondary accessions: Q16410 Q6R2F7 Q9UE27 Q9UM53

Post-translational modifications:

Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate

contraction (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000247.2

ENSEMBL proteins:

ENSP00000382193 ENSP00000256993

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005863	striated muscle thick filament	IEA	--
GO:0014705	C zone	NAS	15166115

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Antibodies for MYBPC3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MYBPC3
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MYBPC3

Assays for MYBPC3:

	Browse Invitrogen for biochemical assays
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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14896

ProtoNet protein and cluster: Q14896

4 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

IPB013098 Immunoglobulin I-set

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: MYPC3_HUMAN, Q14896

Similarity: Belongs to the immunoglobulin superfamily. MyBP family

Similarity: Contains 3 fibronectin type-III domains

Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYBPC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000256

Applied Biosystems Silencer® siRNAs for MYBPC3

Sigma-Aldrich siRNA for MYBPC3

Sigma-Aldrich shRNA for MYBPC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000256
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000256
untagged cDNA clone in CMV expression vector: NM_000256

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000256

UniProtKB/Swiss-Prot: MYPC3_HUMAN, Q14896

Function: Thick filament-associated protein located in the crossbridge region of vertebrate

striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies

the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a

more structural role

Genatlas biochemistry entry for MYBPC3:

myosin and titin binding protein C3,expressed in the A band of sarcomeres,including two isoforms

cardiac and fast skeletal muscle,interacting with beta myosin S2

2 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mybpc3):

muscle

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001671	ATPase activator activity	ISS	--
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IDA	15601779
GO:0008307	structural constituent of muscle	IMP	7493025
GO:0031432	titin binding	NAS	7493025

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for MYBPC3

5/42 Interacting proteins for MYBPC3 (Q14896² ENSP00000256993³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYBPC3	Q14896²	MINT-6174828 MINT-6174845
SMURF2	Q9HAU4²	MINT-6503920
TRIM63	Q969Q1²	MINT-6503410
TNNI3	ENSP00000341838³	STRING (score=.996)
TNNT2	ENSP00000356286³	STRING (score=.992)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003007	heart morphogenesis	IMP	7493025
GO:0006942	regulation of striated muscle contraction	ISS	--
GO:0007155	cell adhesion	IEA	--
GO:0032781	positive regulation of ATPase activity	ISS	--
GO:0032971	regulation of muscle filament sliding	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MYBPC3
1 Novoseek chemical compound relationship for MYBPC3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	0.00	2	18573260 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYBPC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000256

Sigma-Aldrich siRNA for MYBPC3

Sigma-Aldrich shRNA for MYBPC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000256

REFSEQ mRNAs for MYBPC3 gene:

NM_000256.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000256

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000256
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000256
                                 untagged cDNA clone in CMV expression vector: NM_000256

Additional cDNA sequence:

AK291569.1 AK297843.1 BC136543.1 BC136546.1 BC142685.1 BC151211.1 EF560722.1 EU747718.1

EU747719.1 S80778.1

3 DOTS entries:

DT.114602 DT.95265060 DT.101964765

24/77 AceView cDNA sequences (see all 77 ):

AA377609 AI332327 AL600070 C05523 C05630 AI192890 AJ706951 CD607897

C05362 AJ710378 CF552841 CD607901 AJ708699 AL600774 AJ709609 S80778

AU140784 AA427605 AI218137 C03342 AJ707244 C04273 CF552219 AL601194

highest scoring ESTs for MYBPC3:

AU140784 BX502955 BX502961 BX502964 AA091776 AA094747 AA247545 AA247619 AA248782 AA249307

Unigene Cluster for MYBPC3:

Myosin binding protein C, cardiac

Hs.524906 [show with all ESTs]

Unigene Representative Sequence: BC142685

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MYBPC3 (see all 11 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	·	14c	^	15a	·	15b	^	16	^	17	^	18	^
SP1:
SP2:
SP3:																									-
SP4:
SP5:

ExUns:	19a	·	19b	^	20	^	21	^	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MYBPC3

2 Ensembl transcripts including schematic representations:

ENST00000399249 ENST00000256993

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MYBPC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYBPC3

¹ / ² / ³

5 probe-sets matching MYBPC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35038_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y10129	0.20	1.00	0.72	1
208040_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000256	0.60	1.00	0.82	1
238199_x_at²	U133-B	4	0.55	0.36	--	--	--	--	--	--	--
208040_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238199_x_at²	U133Plus2	2	0.55	0.71	--	--	--	--	--	--	--

GeneDecks MYBPC3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCAGCAAGC

SOURCE GeneReport for Unigene cluster: Hs.524906
Expression variation in blood from EXPOLDB for MYBPC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYBPC3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYBPC3¹	--	myosin binding protein C, cardiac	87.91(n) 91.43(a)	483624 XM_540744.2 XP_540744.2
chimpanzee (Pan troglodytes)	MYBPC3¹	--	myosin binding protein C, cardiac	98(n) 97.78(a)	451168 XM_508410.2 XP_508410.2
cow (Bos taurus)	MYBPC3¹	--	myosin binding protein C, cardiac	87.75(n) 89.98(a)	767614 NM_001076536.1 NP_001070004.1
rat (Rattus norvegicus)	Mybpc3¹	--	myosin binding protein C, cardiac	85.75(n) 89.76(a)	295929 XM_215771.4 XP_215771.4
mouse (Mus musculus)	Mybpc3^{1, 5}	2⁵	myosin binding protein C, cardiac^{1, 5}	86.34(n)¹ 90.35(a)¹	17868¹ NM_008653.2¹ NP_032679.2¹ AF059576⁵ AF097333⁵ (see all 13)

About this table Species with no ortholog for MYBPC3

ENSEMBL Gene Tree for MYBPC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYBPC3 gene

MYBPC2² MYBPC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/241 NCBI SNPs in MYBPC3 are shown (see all 241 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 140)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs6485752^1,2	A,C,F	47331487(+)	`acacaC/Tacaca`	1	--	ng3¹ tfbs³		1	NS	144
--	rs3729986^1,2	C,F,H	47328174(-)	`TCTTCG/ATGATG`	1	M/V	mis¹		5	NS EU EA WA	582
--	rs2856661^1,2	A,C,F	47331574(-)	`actccC/Ttggac`	1	--	ng3¹		1	NS	142
	rs11570042^1,2	C,F,H	47331165(-)	`CACTGC/TCTGAA`	1	--	ng3¹		11	NS EU EA WA	1260
	rs3729952^1,2	C,F,H	47315622(-)	`TGAAGC/TGCGGC`	1	A/V	mis¹ ese³		10	NS EU EA WA NA	1094
--	rs11039194^1,2	A,C,F	47331504(+)	`ttagcC/Gaggtg`	1	--	ng3¹		1	NS	144
	rs11570123^1,2	C,F,H	47309046(-)	`CCTACA/GGCATT`	1	--	ng5¹		11	NS EU EA WA	1236
	rs11570076^1,2	C,F,H	47321698(-)	`AGATCC/TGGCTG`	1	R/W	mis¹ ese³		9	NS EU EA WA	1014
	rs3729989^1,2	C,F,H	47326617(-)	`CTGGCA/GGCTAC`	1	S/G	mis¹ ese³		12	NS EU EA WA NA	1322
	rs11570121^1,2	F,H	47309634(-)	`GGAGGG/ATGGCC`	1	--	ut3¹ ese³ trp³		5	NS EU EA WA	558

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HapMap Linkage Disequilibrium images for MYBPC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600958 disorders: 115197 115200

UniProtKB/Swiss-Prot: MYPC3_HUMAN, Q14896

Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4)

[MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by

ventricular hypertrophy, which is usually asymmetric and often involves the interventricular

septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be

readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from

benign to malignant forms with high risk of cardiac failure and sudden cardiac death

10 Novoseek disease relationships for MYBPC3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
death sudden cardiac	67.29	1	16004897 (1)
ventricular hypertrophy	66.97	2	19356534 (1)
death sudden	64.20	4	16630449 (1), 18957093 (1), 15519027 (1), 18383048 (1)
cardiomyopathy	62.27	13	19151713 (2), 17937428 (1), 18403758 (1), 12787675 (1) (see all 5)
hypertrophy	60.07	9	9800880 (1), 15519027 (1), 9475582 (1), 12860568 (1) (see all 7)
cardiomyopathy hypertrophic obstructive	54.22	2	19219553 (1)
cardiac hypertrophy	53.03	2	15737656 (2)
dilated cardiomyopathy	49.94	3	18957093 (2), 17224687 (1)
heart diseases	42.41	3	15115610 (1), 16566405 (1), 12787675 (1)
heart failure	37.17	8	18957093 (1), 17560599 (1), 19151713 (1), 18573260 (1)

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GeneTests: MYBPC3

Dilated Cardiomyopathy

Human Gene Mutation Database: MYBPC3
Genetic Association Database: MYBPC3
Human Genome Epidemiology Navigator: MYBPC3 (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/149 PubMed articles for MYBPC3 gene (see all 149 ):

Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. (PubMed id 15519027)^{1, 3, 4, 6} Van Driest S.L.... Ackerman M.J. (2004)
Mutations profile in Chinese patients with hypertrophic cardiomyopathy. (PubMed id 15563892)^{1, 3, 4, 6} Song L.... Hui R. (2005)
The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in the Netherlands. (PubMed id 14563344)^{1, 3, 4, 6} Alders M.... Mannens M. (2003)
Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy. (PubMed id 7493026)^{1, 3, 4, 6} Bonne G.... Schwartz K. (1995)
Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. (PubMed id 16199542)^{1, 3, 4, 6} Ingles J.... Semsarian C. (2005)
Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction? (PubMed id 7744002)^{1, 2, 3, 4} Gautel M.... Labeit S. (1995)
Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. (PubMed id 9048664)^{1, 3, 4} Carrier L....Schwartz K. (1997)
Spectrum of clinical phenotypes and gene variants in cardiac myosin- binding protein C mutation carriers with hypertrophic cardiomyopathy. (PubMed id 11499719)^{1, 3, 4} Erdmann J.... Regitz-Zagrosek V. (2001)
Molecular pathology of familial hypertrophic cardiomyopathy caused by mutations in the cardiac myosin binding protein C gene. (PubMed id 9541104)^{1, 3, 4} Yu B....Trent R.J. (1998)
Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy. (PubMed id 12787675)^{1, 3, 4} Idowu S.M.... Pfuhl M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4607	HGNC: 7551	AceView: MYBPC3	Ensembl:ENSG00000134571	euGenes: HUgn4607
ECgene: MYBPC3	H-InvDB: MYBPC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Familial hypertrophic cardiomyopathy mutation database	http://www.angis.org.au/Databases/Heart/heartbreak.html
GeneReviews	http://www.genetests.org/query?gene=MYBPC3
NIEHS-SNPs	http://egp.gs.washington.edu/data/mybpc3/

Licensable Technologies for MYBPC3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MYBPC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYBPC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYBPC3		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for MYBPC3		Browse small molecules at Sigma-Aldrich
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MYBPC3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for MYBPC3

Summaries
for MYBPC3

Genomic Location
for MYBPC3

Proteins
for MYBPC3

Protein Domains/
Families
for MYBPC3

Gene Function
for MYBPC3

Pathways & Interactions
for MYBPC3

Drugs & Compounds
for MYBPC3

Transcripts
for MYBPC3

Expression
for MYBPC3

Orthologs
for MYBPC3

Paralogs
for MYBPC3

SNPs/Variants
for MYBPC3

Disorders & Mutations
for MYBPC3

Medical News
for MYBPC3

Publications
for MYBPC3

Search for MYBPC3

Genome Databases showing MYBPC3

Other Databases showing MYBPC3

Specialized Databases showing MYBPC3

Licensable Technologies
for MYBPC3

Services
for MYBPC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYBPC3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor MYBPC3

Summariesfor MYBPC3

Genomic Locationfor MYBPC3

Proteinsfor MYBPC3

Protein Domains/Familiesfor MYBPC3

Gene Functionfor MYBPC3

Pathways & Interactionsfor MYBPC3

Drugs & Compoundsfor MYBPC3

Transcriptsfor MYBPC3

Expression for MYBPC3

Orthologsfor MYBPC3

Paralogsfor MYBPC3

SNPs/Variantsfor MYBPC3

Disorders & Mutationsfor MYBPC3

Medical Newsfor MYBPC3

Publicationsfor MYBPC3

Search for MYBPC3

Genome Databases showing MYBPC3

Other Databases showing MYBPC3

Specialized Databases showing MYBPC3

Licensable Technologiesfor MYBPC3

Servicesfor MYBPC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYBPC3

Summaries
for MYBPC3

Genomic Location
for MYBPC3

Proteins
for MYBPC3

Protein Domains/
Families
for MYBPC3

Gene Function
for MYBPC3

Pathways & Interactions
for MYBPC3

Drugs & Compounds
for MYBPC3

Transcripts
for MYBPC3

Expression
for MYBPC3

Orthologs
for MYBPC3

Paralogs
for MYBPC3

SNPs/Variants
for MYBPC3

Disorders & Mutations
for MYBPC3

Medical News
for MYBPC3

Publications
for MYBPC3

Licensable Technologies
for MYBPC3

Services
for MYBPC3