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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYBPC2 Gene

protein-coding   GIFtS: 60
GCID: GC19P050936

Myosin Binding Protein C, Fast Type

(Previous names: myosin-binding protein C, fast-type)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin Binding Protein C, Fast Type1 2     Fast MyBP-C2 3
MYBPCF2 3 5     C-Protein, Skeletal Muscle Fast Isoform2 3
Myosin-Binding Protein C, Fast-Type1 2     MYBPC2
Fast-Type Muscle Myosin-Binding-Protein C1 2     

External Ids:    HGNC: 75501   Entrez Gene: 46062   Ensembl: ENSG000000869677   OMIM: 1607935   UniProtKB: Q143243   

Export aliases for MYBPC2 gene to outside databases

Previous GC identifers: GC19P051565 GC19P051297 GC19P055612 GC19P055628 GC19P047274


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYBPC2 Gene:
This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and
cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C
region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform.
Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated
with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. (provided by RefSeq, Jul 2012)

GeneCards Summary for MYBPC2 Gene: 
MYBPC2 (myosin binding protein C, fast type) is a protein-coding gene. Diseases associated with MYBPC2 include hypertrophic cardiomyopathy, and distal arthrogryposis, and among its related super-pathways are Striated Muscle Contraction. GO annotations related to this gene include structural constituent of muscle and actin binding. An important paralog of this gene is MYOM1.

UniProtKB/Swiss-Prot: MYPC2_HUMAN, Q14324
Function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a
bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated
myosin ATPase. It may modulate muscle contraction or may play a more structural role




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYBPC2 gene promoter:
         GR   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYBPC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYBPC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYBPC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

MYBPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBPC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050936:  view genomic region     (about GC identifiers)

Start:
50,936,160 bp from pter      End:
50,969,583 bp from pter
Size:
33,424 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYPC2_HUMAN, Q14324 (See protein sequence)
Recommended Name: Myosin-binding protein C, fast-type  
Size: 1141 amino acids; 128072 Da
3 PDB 3D structures from and Proteopedia for MYBPC2:
2E7C (3D)        2EDK (3D)        2EDN (3D)    
Secondary accessions: A1L4G9

Explore the universe of human proteins at neXtProt for MYBPC2: NX_Q14324

Explore proteomics data for MYBPC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14324

  • MYBPC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYBPC2 Protein Expression
    REFSEQ proteins: NP_004524.3  
    ENSEMBL proteins: 
     ENSP00000350332  
    Reactome Protein details: Q14324
    Human Recombinant Protein Products for MYBPC2: 
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    Cloud-Clone Corp. Proteins for MYBPC2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0032982myosin filament IEA--

    MYBPC2 for ontologies           About GeneDecksing



    MYBPC2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    MYBP: Myosin binding proteins

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q14324

    ProtoNet protein and cluster: Q14324

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003962 Fibronectin type III repeat signature
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: MYPC2_HUMAN, Q14324
    Similarity: Belongs to the immunoglobulin superfamily. MyBP family
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains


    MYBPC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYPC2_HUMAN, Q14324
    Function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a
    bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated
    myosin ATPase. It may modulate muscle contraction or may play a more structural role

         Genatlas biochemistry entry for MYBPC2:
    myosin,and titin binding protein C,skeletal muscle,fast type,expressed in the A band of sarcomeres

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0008307structural constituent of muscle TAS8375400
         
    MYBPC2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MYBPC2:
     Decreased POU5F1-GFP protein e  Decreased viability with pacli  Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYBPC2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYBPC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.87
    Muscle contraction0.65
    Striated Muscle Contraction0.87

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MYBPC2
        Striated Muscle Contraction

    2        Reactome Pathways for MYBPC2
        Muscle contraction
    Striated Muscle Contraction



    MYBPC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYBPC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for MYBPC2 (Q143241, 2, 3 ENSP000003503324) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYBPHQ132033, ENSP000002554164I2D: score=1 STRING: ENSP00000255416
    MYBPC1Q008721, ENSP000003548494EBI-5653200,EBI-5652924 STRING: ENSP00000354849
    GRB2P629933I2D: score=1 
    MYBPC2Q143242MINT-6174859
    TTNQ8WZ421EBI-5653200,EBI-681210
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction ----
    GO:0007155cell adhesion IEA--
    GO:0030049muscle filament sliding TAS--

    MYBPC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYBPC2 (MYPC2)

    Search CenterWatch for drugs/clinical trials and news about MYBPC2 / MYPC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYBPC2 gene: 
    NM_004533.3  

    Unigene Cluster for MYBPC2:

    Myosin binding protein C, fast type
    Hs.85937  [show with all ESTs]
    Unigene Representative Sequence: NM_004533
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357701(uc002psf.2) ENST00000597498
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYBPC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYBPC2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBPC2
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    Additional mRNA sequence: 

    BC129943.1 BC130536.1 BC136389.1 X73113.1 

    3 DOTS entries:

    DT.312957  DT.100725233  DT.313765 

    24/59 AceView cDNA sequences (see all 59):

    AL601688 F19240 CF552888 AA192949 AA211733 CF553029 F36897 F29836 
    AA194784 F37093 X73113 AA586464 BX283568 BE797212 BV198400 NM_004533 
    F32615 AJ346447 F32359 BV198401 CF552200 BV198399 AJ573959 AA583218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYBPC2 expression in normal human tissues (normalized intensities)      MYBPC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCCGGAT
    MYBPC2 Expression
    About this image


    MYBPC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             vastus lateralis   
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Blood (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See MYBPC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYBPC2

    SOURCE GeneReport for Unigene cluster: Hs.85937
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBPC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYBPC2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mybpc21 , 5 myosin binding protein C, fast-type1, 5 85.74(n)1
    92.52(a)1
      7 (28.83 cM)5
    2331991  NM_146189.31  NP_666301.21 
     445016995 
    chicken
    (Gallus gallus)
    Aves MYBPC21 myosin binding protein C, fast type 70.91(n)
    71.24(a)
      425457  NM_001044659.1  NP_001038124.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYBPC26
    myosin binding protein C, fast type
    73(a)
    1 ↔ 1
    6(79585777-79655172)
    zebrafish
    (Danio rerio)
    Actinopterygii mybpc2a1 myosin binding protein C, fast type a 64.11(n)
    63.63(a)
      751793  NM_001045859.1  NP_001039324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149646
    --
    10(a)
    1 → many
    3L(3172817-3178580)


    ENSEMBL Gene Tree for MYBPC2 (if available)
    TreeFam Gene Tree for MYBPC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYBPC2 gene
    MYOM12  IGSF222  MYBPH2  IGFN12  MYBPC12  MYBPC32  MYBPHL2  MYOM32  
    MYOM22  
    11 SIMAP similar genes for MYBPC2 using alignment to 1 protein entry:     MYPC2_HUMAN:
    MYBPH    DKFZp779M1050    MYBPHL    DKFZp451B236    DKFZp451H115    DKFZp451M091
    MYBPC1    MYBPC3    DKFZp451E186    TTN    MUSK

    MYBPC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 SNPs in MYBPC2 are shown (see all 1098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106737351,2
    C--50936669(+) TTTTTTT/-GAGAT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs585907851,2
    C--50936672(+) GGTTT-/ATTTTT 1 -- int10--------
    rs1406431431,2
    C--50943580(+) AAATA-/AAAT/ 
    AAATAAAT
    AAATA
    1 -- int10--------
    rs3718485511,2
    C--50943581(+) AATAA-/AAAT  
            
    AATAA
    1 -- int10--------
    rs587780631,2
    C,F--50943620(+) TAAAT-/AAAT/ 
    AAATAAAT
    GAAAA
    1 -- int12NA 4
    rs595641511,2
    C--50943920(+) GTCTC-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs30870491,2
    C--50947390(-) ATGGA-/TGGA  
            
    CTGGG
    1 -- int10--------
    rs30870481,2
    C--50947396(-) ggatgGATG/-  
            
    gatgg
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs104259921,2
    --50947440(+) ccatcC/Tgctta 1 -- int10--------
    rs24458341,2
    C,F--50948801(+) CCCACC/AACCAC 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for MYBPC2 (50936160 - 50969583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MYBPC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718734CNV Deletion23290073
    esv2661463CNV Deletion23128226
    esv2718733CNV Deletion23290073
    esv2718735CNV Deletion23290073
    esv1338683CNV Deletion17803354
    nsv509750CNV Insertion20534489
    dgv3976n71CNV Loss21882294
    nsv912281CNV Loss21882294
    nsv912282CNV Loss21882294
    nsv912283CNV Gain21882294


    Human Gene Mutation Database (HGMD): MYBPC2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160793    OMIM disorders: --

    4 diseases for MYBPC2:    About MalaCards
    hypertrophic cardiomyopathy    distal arthrogryposis    familial hypertrophic cardiomyopathy    dilated cardiomyopathy

    3 diseases from the University of Copenhagen DISEASES database for MYBPC2:
    Familial hypertrophic cardiomyopathy     Hypertrophic cardiomyopathy     Dilated cardiomyopathy

    MYBPC2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MYBPC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 2.78 1 11273720 (1)

    Genetic Association Database (GAD): MYBPC2
    Human Genome Epidemiology (HuGE) Navigator: MYBPC2 (3 documents)

    Export disorders for MYBPC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYBPC2 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with MYBPC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequence of human fast-type and slow-type muscle myosin- binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. (PubMed id 8375400)1, 2, 3, 9 Weber F.E.... Fischman D.A. (1993)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. (PubMed id 12154082)1, 9 Welikson R.E. and Fischman D.A. (2002)
    4. Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain. (PubMed id 9252413)1, 9 Alyonycheva T.N....Fischman D.A. (1997)
    5. Differential methylation of CpG sites in two isoforms of myosin binding protein C, an important hypertrophic cardiomyopathy gene. (PubMed id 20740642)1 Meurs K.M. and Kuan M. (2011)
    6. A frameshift deletion mutation in the cardiac myosin- binding protein C gene associated with dilated phase of hypertrophic cardiomyop athy and dilated cardiomyopathy. (PubMed id 20605413)1 Hitomi N....Doi Y.L. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. Computational analysis of folding and mutation properties of C5 domain of myosin binding protein C. (PubMed id 17876814)1 Guardiani C....Livi R. (2008)
    9. Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. (PubMed id 18201573)1 Flashman E....Moolman-Smook J.C. (2008)
    10. Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. (PubMed id 18817784)1 Luther P.K....Moss R.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4606 HGNC: 7550 AceView: MYBPC2 Ensembl:ENSG00000086967 euGenes: HUgn4606
    ECgene: MYBPC2 H-InvDB: MYBPC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYBPC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYBPC2 gene:
    Search GeneIP for patents involving MYBPC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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