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Aliases for MYBL2 Gene

Aliases for MYBL2 Gene

  • MYB Proto-Oncogene Like 2 2 3 5
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2 2 3
  • Myb-Like Protein 2 3 4
  • B-MYB 3 4
  • BMYB 3 4
  • V-Myb Myeloblastosis Viral Oncogene Homolog-Like 2 3
  • Myb-Related Protein B 3

External Ids for MYBL2 Gene

Previous GeneCards Identifiers for MYBL2 Gene

  • GC20P042024
  • GC20P042934
  • GC20P042981
  • GC20P041729
  • GC20P042295
  • GC20P039031

Summaries for MYBL2 Gene

Entrez Gene Summary for MYBL2 Gene

  • The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for MYBL2 Gene

MYBL2 (MYB Proto-Oncogene Like 2) is a Protein Coding gene. Diseases associated with MYBL2 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Cell cycle Cell cycle (generic schema) and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for MYBL2 Gene

  • Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Gene Wiki entry for MYBL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL2 Gene

Genomics for MYBL2 Gene

Regulatory Elements for MYBL2 Gene

Enhancers for MYBL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G043656 1.8 FANTOM5 Ensembl ENCODE 18.2 -9.3 -9340 2.8 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 IFT52 MYBL2 SGK2 OSER1 SRSF6 L3MBTL1 GC20P043655
GH20G043680 1.3 Ensembl ENCODE dbSUPER 19.2 +15.1 15085 2.8 WRNIP1 SCRT2 ZNF143 RELB ETV6 IKZF2 CREM HCFC1 SMAD5 CBFB IFT52 MYBL2 GC20M043632
GH20G043666 1 ENCODE 21.4 +0.2 197 2.1 ARID4B E2F7 SIN3A ZNF48 ZNF121 GLIS2 KLF7 SP3 SP5 MXD4 IFT52 MYBL2 GC20M043632
GH20G043721 1 Ensembl ENCODE 18.5 +55.2 55200 1.0 CTCF USF1 ZFP64 ZIC2 RELA GLIS2 EGR1 RELB ZBTB20 USF2 IFT52 MYBL2 GTSF1L GC20M043632
GH20G043589 1.1 ENCODE 16.1 -76.2 -76220 2.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 IFT52 MYBL2 RPL27AP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYBL2 on UCSC Golden Path with GeneCards custom track

Promoters for MYBL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137400 81 1001 ARID4B E2F7 SIN3A ZNF48 ZNF121 GLIS2 KLF7 SP3 SP5 MXD4

Genomic Location for MYBL2 Gene

Chromosome:
20
Start:
43,667,019 bp from pter
End:
43,716,496 bp from pter
Size:
49,478 bases
Orientation:
Plus strand

Genomic View for MYBL2 Gene

Genes around MYBL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYBL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL2 Gene

Proteins for MYBL2 Gene

  • Protein details for MYBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10244-MYBB_HUMAN
    Recommended name:
    Myb-related protein B
    Protein Accession:
    P10244
    Secondary Accessions:
    • B2RBS5
    • B7Z8D9
    • F8W6N6
    • Q53F07

    Protein attributes for MYBL2 Gene

    Size:
    700 amino acids
    Molecular mass:
    78764 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.

    Alternative splice isoforms for MYBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL2 Gene

Post-translational modifications for MYBL2 Gene

  • Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYBL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYBL2 Gene

Domains & Families for MYBL2 Gene

Gene Families for MYBL2 Gene

Protein Domains for MYBL2 Gene

Suggested Antigen Peptide Sequences for MYBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYBL2: view

No data available for UniProtKB/Swiss-Prot for MYBL2 Gene

Function for MYBL2 Gene

Molecular function for MYBL2 Gene

GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog-like 2
UniProtKB/Swiss-Prot Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Gene Ontology (GO) - Molecular Function for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10770937
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10770937
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10770937
genes like me logo Genes that share ontologies with MYBL2: view
genes like me logo Genes that share phenotypes with MYBL2: view

Animal Models for MYBL2 Gene

MGI Knock Outs for MYBL2:

Animal Model Products

CRISPR Products

Targeted motifs for MYBL2 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL2
  • Consensus sequence: NHAACBGYYV Submotif: canonical Cell Type: Hela GEO ID: GSE27030

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYBL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL2 Gene

Localization for MYBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYBL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0031523 Myb complex IEA --
genes like me logo Genes that share ontologies with MYBL2: view

Pathways & Interactions for MYBL2 Gene

genes like me logo Genes that share pathways with MYBL2: view

Pathways by source for MYBL2 Gene

SIGNOR curated interactions for MYBL2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with MYBL2: view

Drugs & Compounds for MYBL2 Gene

(4) Drugs for MYBL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MYBL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYBL2: view

Transcripts for MYBL2 Gene

mRNA/cDNA for MYBL2 Gene

Unigene Clusters for MYBL2 Gene

V-myb myeloblastosis viral oncogene homolog (avian)-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYBL2

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - - -
SP10: -
SP11: - - -
SP12:
SP13:

ExUns: 16b · 16c ^ 17a · 17b
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MYBL2 Gene

GeneLoc Exon Structure for
MYBL2
ECgene alternative splicing isoforms for
MYBL2

Expression for MYBL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYBL2 Gene

mRNA differential expression in normal tissues according to GTEx for MYBL2 Gene

This gene is overexpressed in Spleen (x6.2), Testis (x4.4), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MYBL2 Gene

This gene is overexpressed in Lymph node (29.9), Plasma (23.4), and Heart (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYBL2 Gene



Protein tissue co-expression partners for MYBL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYBL2 Gene:

MYBL2

SOURCE GeneReport for Unigene cluster for MYBL2 Gene:

Hs.179718

Evidence on tissue expression from TISSUES for MYBL2 Gene

  • Nervous system(4.6)
  • Eye(4.1)
  • Intestine(3.1)
  • Lung(2.3)
  • Skin(2)
genes like me logo Genes that share expression patterns with MYBL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBL2 Gene

Orthologs for MYBL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBL2 34 35
  • 96.71 (n)
dog
(Canis familiaris)
Mammalia MYBL2 34 35
  • 88.59 (n)
cow
(Bos Taurus)
Mammalia MYBL2 34 35
  • 87.48 (n)
rat
(Rattus norvegicus)
Mammalia Mybl2 34
  • 85.1 (n)
mouse
(Mus musculus)
Mammalia Mybl2 34 16 35
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia MYBL2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYBL2 34 35
  • 72.57 (n)
lizard
(Anolis carolinensis)
Reptilia MYBL2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mybl2 34
  • 63.11 (n)
Str.10235 34
African clawed frog
(Xenopus laevis)
Amphibia myb1 34
zebrafish
(Danio rerio)
Actinopterygii mybl2 34 35
  • 74.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Myb 36 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 35
  • 15 (a)
OneToMany
Species where no ortholog for MYBL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBL2 Gene

ENSEMBL:
Gene Tree for MYBL2 (if available)
TreeFam:
Gene Tree for MYBL2 (if available)

Paralogs for MYBL2 Gene

Paralogs for MYBL2 Gene

(4) SIMAP similar genes for MYBL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MYBL2 Gene

genes like me logo Genes that share paralogs with MYBL2: view

Variants for MYBL2 Gene

Sequence variations from dbSNP and Humsavar for MYBL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000040800 -- 43,665,272(+) CCTCT(C/T)AGCAC upstream-variant-2KB
rs1000072888 -- 43,670,875(+) ACCTG(A/G)TGCAG intron-variant
rs1000073365 -- 43,693,485(+) AGGTG(A/C)ACACC intron-variant
rs1000128444 -- 43,670,489(+) TTCTT(A/T)TTGAC intron-variant
rs1000135141 -- 43,709,898(+) GCCAG(A/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYBL2 Gene

Variant ID Type Subtype PubMed ID
esv2606313 CNV insertion 19546169
esv2854458 CNV duplication 24192839
esv3302967 CNV tandem duplication 20981092
esv3645886 CNV gain 21293372
esv3645889 CNV gain 21293372
esv3645890 CNV loss 21293372
nsv1057847 CNV loss 25217958
nsv1114218 CNV deletion 24896259
nsv1117285 CNV tandem duplication 24896259
nsv1127838 CNV deletion 24896259
nsv1131592 CNV deletion 24896259
nsv1139761 CNV duplication 24896259
nsv180297 CNV deletion 16902084
nsv3385 CNV deletion 18451855

Variation tolerance for MYBL2 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYBL2 Gene

Human Gene Mutation Database (HGMD)
MYBL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL2 Gene

Disorders for MYBL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYBL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
paraneoplastic cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards
Search MYBL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYBL2

Genetic Association Database (GAD)
MYBL2
Human Genome Epidemiology (HuGE) Navigator
MYBL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYBL2
genes like me logo Genes that share disorders with MYBL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYBL2 Gene

Publications for MYBL2 Gene

  1. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PMID: 10095772) Bartsch O. … Ferrari S. (Eur. J. Biochem. 1999) 3 4 22 64
  2. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PMID: 9840932) Saville M.K. … Watson R.J. (Oncogene 1998) 3 4 22 64
  3. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PMID: 8812502) Noben-Trauth K. … Klempnauer K.H. (Genomics 1996) 2 3 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. In vitro and in vivo analysis of B-Myb in basal-like breast cancer. (PMID: 19043454) Thorner A.R. … Perou C.M. (Oncogene 2009) 3 22 64

Products for MYBL2 Gene

  • Addgene plasmids for MYBL2

Sources for MYBL2 Gene

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