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MYBL2 Gene

protein-coding   GIFtS: 68
GCID: GC20P042295

V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 21 2     Myb-Related Protein B2
BMYB2 3 5     V-Myb Myeloblastosis Viral Oncogene Homolog-Like 22
Myb-Like Protein 22 3     B-Myb3
B-MYB2     

External Ids:    HGNC: 75481   Entrez Gene: 46052   Ensembl: ENSG000001010577   OMIM: 6014155   UniProtKB: P102443   

Export aliases for MYBL2 gene to outside databases

Previous GC identifers: GC20P042024 GC20P042934 GC20P042981 GC20P041729 GC20P039031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYBL2 Gene:
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein
involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2
during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to
activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for MYBL2 Gene:
MYBL2 (v-myb avian myeloblastosis viral oncogene homolog-like 2) is a protein-coding gene. Diseases associated with MYBL2 include paraneoplastic cerebellar degeneration, and cerebellar degeneration. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYB.

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244
Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.
Transactivates the expression of the CLU gene

Gene Wiki entry for MYBL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYBL2 gene promoter:
         Sp1   p53   POU3F1   Meis-1b   E2F   E2F-1   FOXO1a   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYBL2 promoter sequence
   Search Chromatin IP Primers for MYBL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYBL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

MYBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042295:  view genomic region     (about GC identifiers)

Start:
42,295,709 bp from pter      End:
42,345,136 bp from pter
Size:
49,428 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244 (See protein sequence)
Recommended Name: Myb-related protein B  
Size: 700 amino acids; 78764 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37,
LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it
represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a
subcomplex that binds to MYBL22
Secondary accessions: B2RBS5

Explore the universe of human proteins at neXtProt for MYBL2: NX_P10244

Explore proteomics data for MYBL2 at MOPED

Post-translational modifications: 

  • Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional
    activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYBL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265539.1  NP_002457.1  

    ENSEMBL proteins: 
     ENSP00000217026   ENSP00000380072  
    Reactome Protein details: P10244

    MYBL2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MYBL2

    MYBL2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for MYBL2

    MYBL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MYBL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYBL2
    Cloud-Clone Corp. CLIAs for MYBL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR015395 C-myb_C
     IPR017930 Myb_dom
     IPR009057 Homeodomain-like
     IPR028311 MYBL2

    Graphical View of Domain Structure for InterPro Entry P10244

    ProtoNet protein and cluster: P10244

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244
    Similarity: Contains 3 HTH myb-type DNA-binding domains


    MYBL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYBB_HUMAN, P10244
    Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.
    Transactivates the expression of the CLU gene

         Genatlas biochemistry entry for MYBL2:
    avian myeloblastosis viral (v-myb) oncogene homolog-like 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17159899
         
    MYBL2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MYBL2:
     Cell cycle / mitosis defect  Increased cell number in G2M,   Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mybl2):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 
     no phenotypic analysis  normal  tumorigenesis 

    MYBL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYBL2: Mybl2tm1Sis Mybl2tm1.2Jof

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYBL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYBL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYBL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYBL2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NHAACBGYYV 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYBL2:
    hsa-mir-505-3p (MIRT041019), hsa-mir-423-5p (MIRT038033), hsa-mir-92a-3p (MIRT049701), hsa-mir-149-3p (MIRT021213)

    Block miRNA regulation of human, mouse, rat MYBL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYBL2 (see all 16):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYBL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYBL2
    Predesigned siRNA for gene silencing in human, mouse, rat MYBL2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MYBL2 (NM_002466)
    Sino Biological Human cDNA Clone for MYBL2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYBB_HUMAN, P10244: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0031523Myb complex IEA--

    MYBL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYBL2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    4HTLV-I infection
    HTLV-I infection
    5Gastric cancer network 1
    Gastric cancer network 1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MYBL2
        Gastric cancer network 1
    E2F transcription factor network


    2 Reactome Pathways for MYBL2
        G0 and Early G1
    Polo-like kinase mediated events


    1 Kegg Pathway  (Kegg details for MYBL2):
        HTLV-I infection


    MYBL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MYBL2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYBL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYBL2 (P102441, 2, 3 ENSP000002170264) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN9Q5TKA11, 2, 3, ENSP000003291024EBI-1389468,EBI-1389424 MINT-4054250 MINT-4054241 MINT-4054263 MINT-4301520 I2D: score=4 STRING: ENSP00000329102
    LIN54Q6MZP71, 2, 3, ENSP000003419474EBI-1389468,EBI-1389411 MINT-7239376 I2D: score=3 STRING: ENSP00000341947
    MAP1LC3BQ9GZQ82, 3MINT-8259704 I2D: score=2 
    MAPK6Q166592, 3MINT-8261505 I2D: score=2 
    ENSG00000224145Q9C0193, ENSP000003982244I2D: score=1 STRING: ENSP00000398224
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007049cell cycle ----
    GO:0051726regulation of cell cycle TAS--

    MYBL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYBL2 (MYBB)

    9 Novoseek inferred chemical compound relationships for MYBL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 22.1 3 1717494 (1), 9521863 (1), 11464857 (1)
    dihydrofolate 20.1 1 12565705 (1)
    thymidylate 17.8 1 11867723 (1)
    retinoic acid 13.5 6 9049836 (2), 12404122 (2)
    chloramphenicol 1.35 4 10344757 (2), 7721862 (1)
    oligonucleotide 0 1 11423988 (1)
    tyrosine 0 1 17418011 (1)
    cycloheximide 0 3 1717494 (1), 8598228 (1)
    cyclosporin a 0 1 1376749 (1)



    MYBL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYBL2 gene (2 alternative transcripts): 
    NM_001278610.1  NM_002466.3  

    Unigene Cluster for MYBL2:

    V-myb myeloblastosis viral oncogene homolog (avian)-like 2
    Hs.179718  [show with all ESTs]
    Unigene Representative Sequence: BX647151
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217026(uc002xlb.1 uc010zwj.1) ENST00000396863
    miRNA
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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYBL2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MYBL2
      QuantiFast Probe-based Assays in human, mouse, rat MYBL2

    Additional mRNA sequence: 

    AK223482.1 AK303249.1 AK314791.1 BC007585.1 BC053555.1 BX647151.1 X13293.1 

    21 DOTS entries:

    DT.100795111  DT.318246  DT.100038396  DT.99993278  DT.100795098  DT.91764270  DT.91764272  DT.100795097 
    DT.86590214  DT.95069875  DT.95170001  DT.120804957  DT.95169997  DT.95170000  DT.120804928  DT.120804954 
    DT.120804959  DT.120804973  DT.120804978  DT.120804990  DT.91764255 

    Selected AceView cDNA sequences (see all 367):

    CA455193 BX388187 BX115559 BU944590 BI196775 BQ437722 BE252930 AW610505 
    AW249925 BE870738 BM827211 BQ900643 BQ069161 BX482287 NM_002466 BM454013 
    BX353484 BG574252 BM825590 BU181815 BM769698 BQ680102 BG682204 CA487337 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                    -     -                 -           -     -                                                     -     -                 -               
    SP2:                    -     -                 -           -                                                                                                   
    SP3:                    -     -     -           -           -     -                                                                                             
    SP4:                                                                                                                                            -           -   
    SP5:                    -     -     -           -           -     -                                                                                             

    ExUns: 16b · 16c ^ 17a · 17b
    SP1:        -               
    SP2:                        
    SP3:                        
    SP4:        -               
    SP5:                        


    ECgene alternative splicing isoforms for MYBL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYBL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCCTG
    MYBL2 Expression
    About this image


    MYBL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; non-germinal center cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Epithelial Cells (Uncategorized)
             tonsil ; squamous epithelial cells   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
    MYBL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYBL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179718
        Pathway & Disease-focused RT2 Profiler PCR Array including MYBL2: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MYBL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYBL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mybl21 , 5 myeloblastosis oncogene-like 21, 5 84.24(n)1
    85.82(a)1
      2 (84.00 cM)5
    178651  NM_008652.21  NP_032678.11 
     1630546875 
    chicken
    (Gallus gallus)
    Aves MYBL21 v-myb myeloblastosis viral oncogene homolog-like 2 72.57(n)
    74.34(a)
      396258  NM_205318.1  NP_990649.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYBL26
    v-myb avian myeloblastosis viral oncogene homolog-...
    66(a)
    1 ↔ 1
    GL343365.1(670358-697014)
    African clawed frog
    (Xenopus laevis)
    Amphibia myb12 myb-related protein 1 75.73(n)    M75870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mybl21 myeloblastosis oncogene-like 2 74.96(n)
    73.02(a)
      445390  NM_001003867.2  NP_001003867.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myb3 cell cycle DNA binding 60(a)   13F14   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BAS16
    Myb-related transcription factor involved in regul...
    15(a)
    1 → many
    XI(635851-638286) YKR099W


    ENSEMBL Gene Tree for MYBL2 (if available)
    TreeFam Gene Tree for MYBL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYBL2 gene
    MYB2  MYBL12  SNAPC42  
    4 SIMAP similar genes for MYBL2 using alignment to 2 protein entries:     MYBB_HUMAN (see all proteins):
    MYB    c-myb    MYBL1    MYB/NFIB fusion

    MYBL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYBL2
    PGOHUM00000245750


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYBL2 (see all 1272)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11097831,2
    Cuntested139046807(-) GACAAA/C/TGCTGC 1 -- int16NA EA 134
    rs1819176481,2
    --39029140(+) TGAGGC/GCTGAA 1 -- us2k10--------
    rs4527341,2
    C,F,O,A,H--39029185(-) AGGACA/GCTGAA 1 -- us2k125Minor allele frequency- G:0.25MN NS EA NA WA CSA 2716
    rs739078891,2
    C,F--39029208(+) ATTTAT/CCTTCC 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1421281251,2
    --39029221(+) TCAGCA/CCTGCT 1 -- us2k10--------
    rs1865693331,2
    --39029227(+) CTGCTC/TCCAGG 1 -- us2k10--------
    rs60310231,2
    H--39029306(+) CTCAAG/AGAAag 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1116828881,2
    C--39029319(+) AGTCTC/TACTGT 1 -- us2k10--------
    rs761901031,2
    C,F--39029352(+) GTGGCG/AGGATG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1826929671,2
    --39029411(+) CTCTGC/TTTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYBL2 (42295709 - 42345136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYBL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2606313CNV Insertion19546169
    nsv180297CNV Loss16902084
    nsv3385CNV Loss18451855
    esv259941OTHER Complex20981092

    Human Gene Mutation Database (HGMD): MYBL2
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MYBL2:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing MYBL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MYBL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601415    OMIM disorders: --

    Selected diseases for MYBL2 (see all 26):    
    About MalaCards
    paraneoplastic cerebellar degeneration    cerebellar degeneration    endocervicitis    differentiating neuroblastoma
    neuroblastoma    malignant mesothelioma    retinoblastoma    scleroderma
    bladder carcinoma    burkitt's lymphoma    lung cancer susceptibility    osteosarcoma
    kaposi's sarcoma    herpes simplex    lymphoblastic leukemia    chronic lymphocytic leukemia
    sarcoma    cervicitis    leukemia    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for MYBL2:
    Retinoblastoma

    MYBL2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for MYBL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 51.5 9 11464857 (3), 9361185 (2), 8621601 (1), 11500496 (1) (see all 5)
    tumors 9.53 18 10416595 (2), 16299810 (2), 19043454 (2), 17975021 (1) (see all 12)
    cervical carcinoma 9.21 2 14506250 (1)
    osteosarcoma 1 1 8621601 (1)
    leukemia 0 1 11080802 (1)
    cancer lung 0 1 9865724 (1)
    breast cancer 0 12 19043454 (4), 17418011 (3), 10815905 (1)
    cancer 0 6 10228942 (3), 8812502 (1), 16914089 (1)

    Genetic Association Database (GAD): MYBL2
    Human Genome Epidemiology (HuGE) Navigator: MYBL2 (4 documents)

    Export disorders for MYBL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYBL2 gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with MYBL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PubMed id 8812502)1, 3, 9 Noben-Trauth K....Klempnauer K.H. (Genomics 1996)
    2. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PubMed id 9840932)1, 2, 9 Saville M.K. and Watson R.J. (Oncogene 1998)
    3. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PubMed id 10095772)1, 2, 9 Bartsch O.... Ferrari S. (Eur. J. Biochem. 1999)
    4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    8. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (Mol. Cell 2007)
    9. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)1, 2 Schmit F.... Gaubatz S. (Cell Cycle 2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4605 HGNC: 7548 AceView: MYBL2 Ensembl:ENSG00000101057 euGenes: HUgn4605
    ECgene: MYBL2 Kegg: 4605 H-InvDB: MYBL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYBL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYBL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYBL2 gene:
    Search GeneIP for patents involving MYBL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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