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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYBL2 Gene

protein-coding GIFtS: 64
GCID: GC20P042295

v-myb myeloblastosis viral oncogene homolog (avian)-like...

(Previous name: v-myb avian myeloblastosis viral oncogene homolog-like...)

Explore 30 diseases affiliated with
MYBL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2¹ ²		Myb-Like Protein 2² ³
BMYB¹ ² ³ ⁵		Myb-Related Protein B²
B-MYB¹ ²		B-Myb³
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2¹ ²

External Ids:	HGNC: 7548¹	Entrez Gene: 4605²	Ensembl: ENSG00000101057⁷	OMIM: 601415⁵	UniProtKB: P10244³

Export aliases for MYBL2 gene to outside databases

Previous GC identifers: GC20P042024 GC20P042934 GC20P042981 GC20P041729 GC20P039031

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYBL2:

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein

involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during

the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the

cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may

exist for this gene, but their full-length natures have not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244

Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.

Transactivates the expression of the CLU gene

Gene Wiki entry for MYBL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYBL2 gene promoter:
Sp1 p53 POU3F1 Meis-1b E2F E2F-1 FOXO1a Meis-1a Meis-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYBL2 promoter sequence

Search SABiosciences Chromatin IP Primers for MYBL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYBL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.1

MYBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBL2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P042295: view genomic region (about GC identifiers)

Start:	42,295,709 bp from pter	End:	42,345,136 bp from pter
Size:	49,428 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244 (See protein sequence)

Recommended Name: Myb-related protein B

Size: 700 amino acids; 78764 Da

Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52,

LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell

cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to

MYBL22

Subcellular location: Nucleus

Secondary accessions: B2RBS5

Explore the universe of human proteins at neXtProt for MYBL2: NX_P10244

Post-translational modifications:

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional

activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10244

MYBL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002457.1

ENSEMBL proteins:

ENSP00000217026 ENSP00000380072

Reactome Protein details: P10244
Human Recombinant Protein Products:

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	Novus Biologicals MYBL2 Proteins Novus Biologicals MYBL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MYBL2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0031523	Myb complex	IEA	--

MYBL2 for ontologies About GeneDecksing

MYBL2 Antibody Products:

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	ThermoFisher Antibodies for MYBL2

Assay Products for MYBL2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MYBL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYBL2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001005 SANT/Myb

IPR009057 Homeodomain-like

IPR015395 C-myb_C

IPR017930 Myb_dom

Graphical View of Domain Structure for InterPro Entry P10244

ProtoNet protein and cluster: P10244

1 Blocks protein family: IPB001005 Myb DNA-binding domain

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244

Similarity: Contains 3 HTH myb-type DNA-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244

Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.

Transactivates the expression of the CLU gene

Genatlas biochemistry entry for MYBL2:

avian myeloblastosis viral (v-myb) oncogene homolog-like 2

miRNA Products:		OriGene 3'-UTR Clone: MYBL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYBL2
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MYBL2 (see all 16):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: MYBL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYBL2 (see all 7) OriGene shRNA RFP: MYBL2 OriGene siRNA: MYBL2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYBL2

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		GenScript: all cDNA clones in your preferred vector: MYBL2 (NM_002466)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYBL2
		Search LifeMap BioReagents cell lines for MYBL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	10770937

MYBL2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for MYBL2:

Cell cycle / mitosis defect

Increased cell number in G2M,

Synthetic lethal with Ras

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for MYBL2: Mybl2^tm1Sis Mybl2^tm1.2Jof
5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Mybl2):

cellular

embryogenesis

mortality/aging

no phenotypic analysis

normal

MYBL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

E2F transcription factor network

E2F transcription factor network

1.00

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

1.00

G1/S Transition

Mitotic G1-G1/S phases

0.80

Cell cycle_Cell cycle (generic schema)

G0 and Early G1

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for MYBL2

E2F transcription factor network

5 Reactome Pathways for MYBL2

	Mitotic G1-G1/S phases
	G0 and Early G1
	Cell Cycle
	Cell Cycle, Mitotic
	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

MYBL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MYBL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/55 Interacting proteins for MYBL2 (P10244^{2, 3} ENSP00000217026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LIN9	Q5TKA1²^,³, ENSP00000329102⁴	MINT-4054250 MINT-4054241 MINT-4054263 MINT-4301520 I2D: score=4 STRING: ENSP00000329102
LIN54	Q6MZP7²^,³, ENSP00000341947⁴	MINT-7239376 I2D: score=3 STRING: ENSP00000341947
MAP1LC3B	Q9GZQ8²^,³	MINT-8259704 I2D: score=2
MAPK6	Q16659²^,³	MINT-8261505 I2D: score=2
E2F3	O00716²^,³, ENSP00000262904⁴	MINT-4053806 I2D: score=2 STRING: ENSP00000262904

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000278	mitotic cell cycle	TAS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0090307	spindle assembly involved in mitosis	IEA	--

MYBL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYBL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYBL2
9 Novoseek chemical compound relationships for MYBL2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thymidine	22.1	3	1717494 (1), 9521863 (1), 11464857 (1)
dihydrofolate	20.1	1	12565705 (1)
thymidylate	17.8	1	11867723 (1)
retinoic acid	13.5	6	9049836 (2), 12404122 (2)
chloramphenicol	1.35	4	10344757 (2), 7721862 (1)
oligonucleotide	0	1	11423988 (1)
tyrosine	0	1	17418011 (1)
cycloheximide	0	3	1717494 (1), 8598228 (1)
cyclosporin a	0	1	1376749 (1)

Search CenterWatch for drugs/clinical trials and news about MYBL2 / MYBB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYBL2 gene:

NM_002466.2

Unigene Cluster for MYBL2:

V-myb myeloblastosis viral oncogene homolog (avian)-like 2

Hs.179718 [show with all ESTs]

Unigene Representative Sequence: BX647151

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000217026(uc002xlb.1 uc010zwj.1) ENST00000396863

miRNA Products:		OriGene 3'-UTR Clone: MYBL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYBL2
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MYBL2 (see all 16):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: MYBL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYBL2 (see all 7) OriGene shRNA RFP: MYBL2 OriGene siRNA: MYBL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYBL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYBL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYBL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MYBL2 (NM_002466)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYBL2
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYBL2

Additional cDNA sequence:

AK223482.1 AK303249.1 AK314791.1 BC007585.1 BC053555.1 BX647151.1 X13293.1

21 DOTS entries:

DT.100795111 DT.318246 DT.100038396 DT.99993278 DT.100795098 DT.91764270 DT.91764272 DT.100795097

DT.86590214 DT.95069875 DT.95170001 DT.120804957 DT.95169997 DT.95170000 DT.120804928 DT.120804954

DT.120804959 DT.120804973 DT.120804978 DT.120804990 DT.91764255

24/367 AceView cDNA sequences (see all 367):

AU125600 BQ680102 BQ900643 BF796012 CR593650 BX482287 BQ069161 BX353483

BG686935 BG258564 BM831193 BI193128 CA487337 AW610505 BQ221748 BC053555

BE312877 AU130748 BI196775 BG115665 AA292433 BQ071228 BG682204 BG177609

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·
SP1:							-		-						-				-		-																		-		-						-
SP2:							-		-						-				-
SP3:							-		-		-				-				-		-
SP4:																																															-				-
SP5:							-		-		-				-				-		-

ExUns:	16b	·	16c	^	17a	·	17b
SP1:			-
SP2:
SP3:
SP4:			-
SP5:

ECgene alternative splicing isoforms for MYBL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYBL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGCCCTG

About this image

MYBL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Liver

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYBL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYBL2

SOURCE GeneReport for Unigene cluster: Hs.179718

SABiosciences Expression via Pathway-Focused PCR Array including MYBL2:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYBL2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYBL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYBL2 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYBL2¹	v-myb myeloblastosis viral oncogene homolog (avian)-like more	72.56(n) 73.93(a)		396258 NM_205318.1 NP_990649.1
lizard (Anolis carolinensis)	Reptilia	MYBL2⁶	--	68(a)	1 ↔ 1	GL343365.1(672144-693900)
African clawed frog (Xenopus laevis)	Amphibia	myb1²	myb-related protein 1	75.73(n)		M75870.1
zebrafish (Danio rerio)	Actinopterygii	mybl2¹	myeloblastosis oncogene-like 2	61.77(n) 57.51(a)		445390 NM_001003867.2 NP_001003867.2
fruit fly (Drosophila melanogaster)	Insecta	Myb³	cell cycle DNA binding	60(a)		13F14 --
worm (Caenorhabditis elegans)	Secernentea	gei-11⁶	GEX Interacting protein family member (gei-11)	6(a)	possible ortholog	I(8962315-8966123)
thale cress (Arabidopsis thaliana)	eudicotyledons	MYB100⁶ MYB3R-3⁶ (see all 12)	myb domain protein 3r-3 (see all 12)	24(a) 23(a) (see all 12)	possible ortholog many ↔ many (see all 12)	2(10747211-10748467) 3(2879366-2882267)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	MYB family transcription factor, putative, express... MYB family transcription factor, putative, express... (see all 10)	9(a) 26(a) (see all 10)	possible ortholog possible ortholog (see all 10)	2(9848197-9852415) 6(3157657-3161647)

ENSEMBL Gene Tree for MYBL2 (if available)
TreeFam Gene Tree for MYBL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYBL2 gene

MYB² MYBL1² SNAPC4²

4 SIMAP similar genes for MYBL2 using alignment to 2 protein entries: MYBB_HUMAN (see all proteins):

MYB c-myb MYBL1 MYB/NFIB fusion

MYBL2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MYBL2
PGOHUM00000245750

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141946192^1,2	C,	--	42299601(+)	`ATTTC-/TTTTTT TTCTTTTTTTTTTT`	1	--	int¹		0	--	--	--	--
rs80184594^1,2	C	--	42299609(+)	`TTTTTT/CTTTTT`	1	--	int¹		1		WA	2
rs188744342^1,2		--	42300146(+)	`TCGCTC/TTTGTT`	1	--	int¹		0	--	--	--	--
rs826948^1,2	C,A,	--	42300262(+)	`CATGCG/ACCATC`	1	--	int¹		2		NA	4
rs191826374^1,2		--	42300303(+)	`GACGGA/GGTTTC`	1	--	int¹		0	--	--	--	--
rs117750650^1,2	F,	--	42300410(+)	`TGGCCC/TGATTT`	1	--	int¹		1		EA	120
rs3091561^1,2	C,F	--	42301068(+)	`AAAAAA/-TCAAC`	1	--	int¹ trp³		3		NA CSA	6
rs3091633^1,2	C	--	42301887(+)	`GCCTC-/TTTTTTT`	1	--	int¹ trp³		1		NA	2
rs11468765^1,2	C	--	42301887(+)	`GCCTC-/TTTTTTT`	1	--	int¹		0	--	--	--	--
rs3091618^1,2	C	--	42303032(+)	`TTTTT-/TTTTGA`	1	--	int¹ trp³		2		NA CSA	4

HapMap Linkage Disequilibrium report for MYBL2 (42295709 - 42345136 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MYBL2
2 Indels: 12187 102976
Human Gene Mutation Database (HGMD): MYBL2

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing MYBL2:

Ovarian Cancer

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYBL2 for disorders           About GeneDecksing

OMIM gene information: 601415    OMIM disorders: --

20/30 diseases for MYBL2 (see all 30):    About MalaCards

paraneoplastic cerebellar degeneration cerebellar degeneration differentiating neuroblastoma acute lymphoblastic leukemia

chronic lymphocytic leukemia malignant mesothelioma lymphoblastic leukemia herpes simplex

lymphocytic leukemia burkitt's lymphoma kaposi's sarcoma endocervicitis

cervical carcinoma embryonal carcinoma bladder carcinoma retinoblastoma

leukemia osteosarcoma lung cancer cervicitis

1 disease from the University of Copenhagen DISEASES database for MYBL2:

Retinoblastoma

8 Novoseek disease relationships for MYBL2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	51.5	9	11464857 (3), 9361185 (2), 8621601 (1), 11500496 (1) (see all 5)
tumors	9.53	18	10416595 (2), 16299810 (2), 19043454 (2), 17975021 (1) (see all 12)
cervical carcinoma	9.21	2	14506250 (1)
osteosarcoma	1	1	8621601 (1)
leukemia	0	1	11080802 (1)
cancer lung	0	1	9865724 (1)
breast cancer	0	12	19043454 (4), 17418011 (3), 10815905 (1)
cancer	0	6	10228942 (3), 8812502 (1), 16914089 (1)

Human Genome Epidemiology (HuGE) Navigator: MYBL2 (4 documents)

Export disorders for MYBL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYBL2 gene, integrated from 9 sources (see all 186):
(articles sorted by number of sources associating them with MYBL2)

Utopia: connect your pdf to the dynamic
world of online information

Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PubMed id 8812502)^{1, 3, 9} Noben-Trauth K....Klempnauer K.H. (1996)
The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PubMed id 9840932)^{1, 2, 9} Saville M.K. and Watson R.J. (1998)
Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PubMed id 10095772)^{1, 2, 9} Bartsch O.... Ferrari S. (1999)
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)^{1, 2} Litovchick L.... DeCaprio J.A. (2007)
LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)^{1, 2} Schmit F.... Gaubatz S. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB. (PubMed id 10770937)^{1, 2} Cervellera M.... Sala A. (2000)
Multiple nuclear localization signals of the B-myb gene product. (PubMed id 8062924)^{1, 2} Takemoto Y.... Ishii S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4605	HGNC: 7548	AceView: MYBL2	Ensembl:ENSG00000101057	euGenes: HUgn4605
ECgene: MYBL2	H-InvDB: MYBL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYBL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MYBL2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MYBL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYBL2 gene:
Search GeneIP for patents involving MYBL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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