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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYBL2 Gene

protein-coding   GIFtS: 68
GCID: GC20P042295

V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 21 2     Myb-Related Protein B2
BMYB2 3 5     V-Myb Myeloblastosis Viral Oncogene Homolog-Like 22
Myb-Like Protein 22 3     B-Myb3
B-MYB2     

External Ids:    HGNC: 75481   Entrez Gene: 46052   Ensembl: ENSG000001010577   OMIM: 6014155   UniProtKB: P102443   

Export aliases for MYBL2 gene to outside databases

Previous GC identifers: GC20P042024 GC20P042934 GC20P042981 GC20P041729 GC20P039031


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYBL2 Gene:
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein
involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2
during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to
activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for MYBL2 Gene: 
MYBL2 (v-myb avian myeloblastosis viral oncogene homolog-like 2) is a protein-coding gene. Diseases associated with MYBL2 include differentiating neuroblastoma, and paraneoplastic cerebellar degeneration, and among its related super-pathways are Cell Cycle, Mitotic and G1/S Transition. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYB.

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244
Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.
Transactivates the expression of the CLU gene

Gene Wiki entry for MYBL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYBL2 gene promoter:
         Sp1   p53   POU3F1   Meis-1b   E2F   E2F-1   FOXO1a   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYBL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYBL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYBL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

MYBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042295:  view genomic region     (about GC identifiers)

Start:
42,295,709 bp from pter      End:
42,345,136 bp from pter
Size:
49,428 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244 (See protein sequence)
Recommended Name: Myb-related protein B  
Size: 700 amino acids; 78764 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37,
LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it
represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a
subcomplex that binds to MYBL22
Subcellular location: Nucleus
Secondary accessions: B2RBS5

Explore the universe of human proteins at neXtProt for MYBL2: NX_P10244

Explore proteomics data for MYBL2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional
    activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10244

  • MYBL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYBL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265539.1  NP_002457.1  

    ENSEMBL proteins: 
     ENSP00000217026   ENSP00000380072  
    Reactome Protein details: P10244
    Human Recombinant Protein Products for MYBL2: 
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    Novus Biologicals MYBL2 Proteins
    Novus Biologicals MYBL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYBL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031523Myb complex IEA--

    MYBL2 for ontologies           About GeneDecksing



    MYBL2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYBL2
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    Abcam antibodies for MYBL2
    Cloud-Clone Corp. Antibodies for MYBL2 
    ThermoFisher Antibodies for MYBL2
    LSBio Antibodies in human, mouse, rat for MYBL2 

    Assay Products for MYBL2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYBL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYBL2 
    Cloud-Clone Corp. CLIAs for MYBL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR015395 C-myb_C
     IPR017930 Myb_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P10244

    ProtoNet protein and cluster: P10244

    1 Blocks protein domain: IPB001005 Myb DNA-binding domain

    UniProtKB/Swiss-Prot: MYBB_HUMAN, P10244
    Similarity: Contains 3 HTH myb-type DNA-binding domains


    MYBL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYBB_HUMAN, P10244
    Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation.
    Transactivates the expression of the CLU gene

         Genatlas biochemistry entry for MYBL2:
    avian myeloblastosis viral (v-myb) oncogene homolog-like 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10770937
    GO:0005515protein binding IPI17159899
         
    MYBL2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MYBL2:
     Cell cycle / mitosis defect  Increased cell number in G2M,   Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mybl2):
     cellular  embryogenesis  mortality/aging  no phenotypic analysis  normal 

    MYBL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYBL2: Mybl2tm1Sis Mybl2tm1.2Jof

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYBL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYBL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYBL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYBL2 

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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYBL2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL2
    Sirion Biotech Customized lentivirus for stable overexpression of MYBL2 
                         Customized lentivirus expression plasmids for stable overexpression of MYBL2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYBL2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    3Cell cycle Cell cycle (generic schema)
    G0 and Early G10.31
    4Gastric cancer network 1
    Gastric cancer network 1
    5E2F transcription factor network
    E2F transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MYBL2
        Gastric cancer network 1
    E2F transcription factor network


    4        Reactome Pathways for MYBL2
        Mitotic G1-G1/S phases
    G0 and Early G1
    Cell Cycle
    Cell Cycle, Mitotic


    1         Kegg Pathway  (Kegg details for MYBL2):
        HTLV-I infection


    MYBL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYBL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for MYBL2 (P102442, 3 ENSP000002170264) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN9Q5TKA12, 3, ENSP000003291024MINT-4054250 MINT-4054241 MINT-4054263 MINT-4301520 I2D: score=4 STRING: ENSP00000329102
    LIN54Q6MZP72, 3, ENSP000003419474MINT-7239376 I2D: score=3 STRING: ENSP00000341947
    MAP1LC3BQ9GZQ82, 3MINT-8259704 I2D: score=2 
    MAPK6Q166592, 3MINT-8261505 I2D: score=2 
    ENSG00000224145Q9C0193, ENSP000003982244I2D: score=1 STRING: ENSP00000398224
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0090307spindle assembly involved in mitosis IEA--

    MYBL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYBL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYBL2 (MYBB)

    9 Novoseek inferred chemical compound relationships for MYBL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 22.1 3 1717494 (1), 9521863 (1), 11464857 (1)
    dihydrofolate 20.1 1 12565705 (1)
    thymidylate 17.8 1 11867723 (1)
    retinoic acid 13.5 6 9049836 (2), 12404122 (2)
    chloramphenicol 1.35 4 10344757 (2), 7721862 (1)
    oligonucleotide 0 1 11423988 (1)
    tyrosine 0 1 17418011 (1)
    cycloheximide 0 3 1717494 (1), 8598228 (1)
    cyclosporin a 0 1 1376749 (1)

    Search CenterWatch for drugs/clinical trials and news about MYBL2 / MYBB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYBL2 gene (2 alternative transcripts): 
    NM_001278610.1  NM_002466.3  

    Unigene Cluster for MYBL2:

    V-myb myeloblastosis viral oncogene homolog (avian)-like 2
    Hs.179718  [show with all ESTs]
    Unigene Representative Sequence: BX647151
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217026(uc002xlb.1 uc010zwj.1) ENST00000396863
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYBL2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MYBL2 (see all 16):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-185* hsa-miR-4251 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYBL2 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for MYBL2 (see all 7)
    OriGene ORF clones in mouse, rat for MYBL2
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    GenScript: all cDNA clones in your preferred vector: MYBL2 (NM_002466)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYBL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL2
    Sirion Biotech Customized lentivirus for stable overexpression of MYBL2 
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    Additional mRNA sequence: 

    AK223482.1 AK303249.1 AK314791.1 BC007585.1 BC053555.1 BX647151.1 X13293.1 

    21 DOTS entries:

    DT.100795111  DT.318246  DT.100038396  DT.99993278  DT.100795098  DT.91764270  DT.91764272  DT.100795097 
    DT.86590214  DT.95069875  DT.95170001  DT.120804957  DT.95169997  DT.95170000  DT.120804928  DT.120804954 
    DT.120804959  DT.120804973  DT.120804978  DT.120804990  DT.91764255 

    24/367 AceView cDNA sequences (see all 367):

    BC007585 AU125600 BX353484 BG682204 BG117236 BX388187 BM974810 BQ691696 
    BI858046 BX482288 BU619778 CR620461 BX115559 BE746183 BU944590 BG574252 
    BM827211 BE312877 BM825590 BM831193 AW610505 BQ221748 AU130748 BE870738 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                    -     -                 -           -     -                                                     -     -                 -               
    SP2:                    -     -                 -           -                                                                                                   
    SP3:                    -     -     -           -           -     -                                                                                             
    SP4:                                                                                                                                            -           -   
    SP5:                    -     -     -           -           -     -                                                                                             

    ExUns: 16b · 16c ^ 17a · 17b
    SP1:        -               
    SP2:                        
    SP3:                        
    SP4:        -               
    SP5:                        


    ECgene alternative splicing isoforms for MYBL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYBL2 expression in normal human tissues (normalized intensities)      MYBL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCCTG
    MYBL2 Expression
    About this image


    MYBL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Hypothalamus
     
     Tonsil (Hematopoietic System)

    See MYBL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYBL2

    SOURCE GeneReport for Unigene cluster: Hs.179718
        SABiosciences Expression via Pathway-Focused PCR Array including MYBL2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYBL2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mybl21 , 5 myeloblastosis oncogene-like 21, 5 84.24(n)1
    85.82(a)1
      2 (84.00 cM)5
    178651  NM_008652.21  NP_032678.11 
     1630546875 
    chicken
    (Gallus gallus)
    Aves MYBL21 v-myb myeloblastosis viral oncogene homolog (avian)-like more 72.56(n)
    73.93(a)
      396258  NM_205318.1  NP_990649.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYBL26
    v-myb myeloblastosis viral oncogene homolog (avian...
    66(a)
    1 ↔ 1
    GL343365.1(670358-697014)
    African clawed frog
    (Xenopus laevis)
    Amphibia myb12 myb-related protein 1 75.73(n)    M75870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mybl21 myeloblastosis oncogene-like 2 61.77(n)
    57.51(a)
      445390  NM_001003867.2  NP_001003867.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myb3 cell cycle DNA binding 60(a)   13F14   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BAS16
    Myb-related transcription factor involved in regul...
    12(a)
    1 → many
    XI(635851-638286)


    ENSEMBL Gene Tree for MYBL2 (if available)
    TreeFam Gene Tree for MYBL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYBL2 gene
    MYB2  MYBL12  SNAPC42  
    4 SIMAP similar genes for MYBL2 using alignment to 2 protein entries:     MYBB_HUMAN (see all proteins):
    MYB    c-myb    MYBL1    MYB/NFIB fusion

    MYBL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYBL2
    PGOHUM00000245750


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1272 SNPs in MYBL2 are shown (see all 1272)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11097831,2
    Cuntested139046807(-) GACAAA/C/TGCTGC 1 -- int16NA EA 134
    rs1819176481,2
    --39029140(+) TGAGGC/GCTGAA 1 -- us2k10--------
    rs4527341,2
    C,F,O,A,H--39029185(-) AGGACA/GCTGAA 1 -- us2k125Minor allele frequency- G:0.25MN NS EA NA WA CSA 2716
    rs739078891,2
    C,F--39029208(+) ATTTAT/CCTTCC 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1421281251,2
    --39029221(+) TCAGCA/CCTGCT 1 -- us2k10--------
    rs1865693331,2
    --39029227(+) CTGCTC/TCCAGG 1 -- us2k10--------
    rs60310231,2
    H--39029306(+) CTCAAG/AGAAag 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1116828881,2
    C--39029319(+) AGTCTC/TACTGT 1 -- us2k10--------
    rs761901031,2
    C,F--39029352(+) GTGGCG/AGGATG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1826929671,2
    --39029411(+) CTCTGC/TTTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYBL2 (42295709 - 42345136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYBL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2606313CNV Insertion19546169
    nsv180297CNV Loss16902084
    nsv3385CNV Loss18451855
    esv259941OTHER Complex20981092


    Human Gene Mutation Database (HGMD): MYBL2
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing MYBL2:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing MYBL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MYBL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601415    OMIM disorders: --

    20/26 diseases for MYBL2 (see all 26):    About MalaCards
    differentiating neuroblastoma    paraneoplastic cerebellar degeneration    cerebellar degeneration    endocervicitis
    retinoblastoma    malignant mesothelioma    osteosarcoma    neuroblastoma
    scleroderma    kaposi's sarcoma    bladder carcinoma    burkitt's lymphoma
    herpes simplex    acute lymphoblastic leukemia    chronic lymphocytic leukemia    cervicitis
    lymphoblastic leukemia    sarcoma    lung cancer    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for MYBL2:
    Retinoblastoma

    MYBL2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for MYBL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 51.5 9 11464857 (3), 9361185 (2), 8621601 (1), 11500496 (1) (see all 5)
    tumors 9.53 18 10416595 (2), 16299810 (2), 19043454 (2), 17975021 (1) (see all 12)
    cervical carcinoma 9.21 2 14506250 (1)
    osteosarcoma 1 1 8621601 (1)
    leukemia 0 1 11080802 (1)
    cancer lung 0 1 9865724 (1)
    breast cancer 0 12 19043454 (4), 17418011 (3), 10815905 (1)
    cancer 0 6 10228942 (3), 8812502 (1), 16914089 (1)

    Genetic Association Database (GAD): MYBL2
    Human Genome Epidemiology (HuGE) Navigator: MYBL2 (4 documents)

    Export disorders for MYBL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYBL2 gene, integrated from 9 sources (see all 193):
    (articles sorted by number of sources associating them with MYBL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PubMed id 8812502)1, 3, 9 Noben-Trauth K....Klempnauer K.H. (1996)
    2. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PubMed id 9840932)1, 2, 9 Saville M.K. and Watson R.J. (1998)
    3. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PubMed id 10095772)1, 2, 9 Bartsch O.... Ferrari S. (1999)
    4. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    5. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    8. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
    9. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)1, 2 Schmit F.... Gaubatz S. (2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4605 HGNC: 7548 AceView: MYBL2 Ensembl:ENSG00000101057 euGenes: HUgn4605
    ECgene: MYBL2 Kegg: 4605 H-InvDB: MYBL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYBL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYBL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYBL2 gene:
    Search GeneIP for patents involving MYBL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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