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MYBL1 Gene

protein-coding   GIFtS: 56
GCID: GC08M067474

V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 11 2     Myb-Related Protein A2
Myb-Like Protein 12 3     V-Myb Myeloblastosis Viral Oncogene Homolog-Like 12
AMYB2 3     A-Myb3
A-MYB2     

External Ids:    HGNC: 75471   Entrez Gene: 46032   Ensembl: ENSG000001856977   OMIM: 1594055   UniProtKB: P102433   

Export aliases for MYBL1 gene to outside databases

Previous GC identifers: GC08M066596 GC08M067414 GC08M067197 GC08M067524 GC08M067526 GC08M067636 GC08M062964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYBL1 Gene:
MYBL1 (v-myb avian myeloblastosis viral oncogene homolog-like 1) is a protein-coding gene. Diseases associated with MYBL1 include burkitt's lymphoma, and leiomyoma. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MYBL2.

UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence
5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and
B-lymphoid cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYBL1 gene promoter:
         HOXA9   HOXA9B   FOXD3   Meis-1b   POU2F1   GATA-6   POU2F1a   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYBL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q22

MYBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBL1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067474:  view genomic region     (about GC identifiers)

Start:
67,474,410 bp from pter      End:
67,526,482 bp from pter
Size:
52,073 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 (See protein sequence)
Recommended Name: Myb-related protein A  
Size: 752 amino acids; 85887 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37,
LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it
represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a
subcomplex that binds to MYBL2
Secondary accessions: E7EW29 Q495F9
Alternative splicing: 2 isoforms:  P10243-1   P10243-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYBL1: NX_P10243

Explore proteomics data for MYBL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79, Lys92, Lys104, Lys166
  • Modification sites at PhosphoSitePlus

  • See MYBL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073885.1  NP_001138227.1  

    ENSEMBL proteins: 
     ENSP00000429633   ENSP00000428265   ENSP00000428011  

    MYBL1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYBL1
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    Novus Biologicals MYBL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYBL1

    MYBL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Abcam antibodies for MYBL1
    Cloud-Clone Corp. Antibodies for MYBL1
    Search ThermoFisher Antibodies for MYBL1
    LSBio Antibodies in human, mouse, rat for MYBL1

    MYBL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYBL1
    Cloud-Clone Corp. CLIAs for MYBL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001005 SANT/Myb
     IPR015395 C-myb_C
     IPR017930 Myb_dom
     IPR028317 MYBL1
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P10243

    ProtoNet protein and cluster: P10243

    2 Blocks protein domains:
    IPB001005 Myb DNA-binding domain
    IPB012642 Mitotic Wos2


    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Similarity: Contains 3 HTH myb-type DNA-binding domains


    MYBL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYBA_HUMAN, P10243
    Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence
    5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and
    B-lymphoid cells

         Genatlas biochemistry entry for MYBL1:
    avian myeloblastosis viral (v-myb) oncogene homolog-like 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
         
    MYBL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYBL1:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mybl1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  normal  reproductive system 

    MYBL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mybl1tm1Epr for MYBL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYBL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYBL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYBL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYBL1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGGCAGTTGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYBL1:
    hsa-mir-373-3p (MIRT002505), hsa-mir-375 (MIRT020041), hsa-mir-15a-5p (MIRT051349), hsa-mir-155-5p (MIRT021060), hsa-mir-193b-3p (MIRT016526), hsa-mir-221-3p (MIRT003361)

    Block miRNA regulation of human, mouse, rat MYBL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYBL1 (see all 72):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-146a hsa-miR-15a hsa-miR-4272 hsa-miR-200a hsa-miR-138-2* hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYBL1
    Predesigned siRNA for gene silencing in human, mouse, rat MYBL1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MYBL1

    Clone
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    OriGene clones in human, mouse for MYBL1 (see all 12)
    OriGene ORF clones in mouse, rat for MYBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYBL1 (NM_001080416)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MYBL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYBL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYBA_HUMAN, P10243: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8058310

    MYBL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYBL1 About    
    See pathways by source

    SuperPathContained pathways About
    1IL4-mediated signaling events
    IL4-mediated signaling events
    2HTLV-I infection
    HTLV-I infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MYBL1
        IL4-mediated signaling events


    1 Kegg Pathway  (Kegg details for MYBL1):
        HTLV-I infection


    MYBL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MYBL1: 
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYBL1

    Selected Interacting proteins for MYBL1 (P102433) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8L2Q9H6S33I2D: score=4 
    MCCP235083I2D: score=3 
    LIN37Q96GY33I2D: score=2 
    LIN54Q6MZP73I2D: score=2 
    LIN9Q5TKA13I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045893positive regulation of transcription, DNA-templated NAS8058310

    MYBL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYBL1 (MYBA)

    1 Novoseek inferred chemical compound relationship for MYBL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 16 2 15879465 (2)



    MYBL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYBL1 gene (2 alternative transcripts): 
    NM_001080416.2  NM_001144755.1  

    Unigene Cluster for MYBL1:

    V-myb myeloblastosis viral oncogene homolog (avian)-like 1
    Hs.445898  [show with all ESTs]
    Unigene Representative Sequence: NM_001080416
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522677(uc003xwj.3 uc003xwl.3 uc003xwk.3) ENST00000517885
    ENST00000524176 ENST00000522419 ENST00000518079 ENST00000523304(uc003xwm.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYBL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYBL1 (see all 72):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-146a hsa-miR-15a hsa-miR-4272 hsa-miR-200a hsa-miR-138-2* hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYBL1
    Predesigned siRNA for gene silencing in human, mouse, rat MYBL1
    Clone
    Products:
         
    OriGene clones in human, mouse for MYBL1 (see all 12)
    OriGene ORF clones in mouse, rat for MYBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYBL1 (NM_001080416)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYBL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYBL1
      QuantiTect SYBR Green Assays in human, mouse, rat MYBL1
      QuantiFast Probe-based Assays in human, mouse, rat MYBL1

    Additional mRNA sequence: 

    AK308490.1 BC032233.1 BC046930.1 BC069252.1 BC101186.1 BC101187.2 BC101188.1 S75881.1 
    X13294.1 X66087.1 

    7 DOTS entries:

    DT.413624  DT.411757  DT.99932314  DT.40125974  DT.100685936  DT.95363382  DT.99972691 

    Selected AceView cDNA sequences (see all 92):

    AA830717 AA768961 BF513374 BC046930 CF137306 BF512152 AW274569 AA687113 
    AA827864 AA911236 AA731205 X13294 BC069252 BC032233 BQ573952 AL135299 
    AA504350 BQ424925 AI869031 AA747541 CD299093 BM544471 H13336 BM456292 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                
    SP2:                                                                                -               


    ECgene alternative splicing isoforms for MYBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACTGACT
    MYBL1 Expression
    About this image


    MYBL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    MYBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYBL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445898

    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro

        Pathway & Disease-focused RT2 Profiler PCR Array including MYBL1: 
              Lymphoma in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYBL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYBL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYBL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mybl11 , 5 myeloblastosis oncogene-like 11, 5 90.95(n)1
    92.68(a)1
      1 (2.08 cM)5
    178641  NM_008651.21  NP_032677.21 
     96674155 
    chicken
    (Gallus gallus)
    Aves MYBL11 v-myb myeloblastosis viral oncogene homolog-like 1 78.78(n)
    79.76(a)
      396158  NM_205232.1  NP_990563.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYBL16
    v-myb avian myeloblastosis viral oncogene homolog-...
    78(a)
    1 ↔ 1
    4(30873961-30901920)
    African clawed frog
    (Xenopus laevis)
    Amphibia xamyb2 xamyb protein 76.43(n)    X72620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mybl11 v-myb myeloblastosis viral oncogene homolog (avian)-like more 58.09(n)
    57.26(a)
      558540  XM_005162751.1  XP_005162808.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myb6
    Myb oncogene-like
    30(a)
    1 → many
    X(15748865-15751854)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BAS16
    Myb-related transcription factor involved in regul...
    14(a)
    1 → many
    XI(635851-638286) YKR099W


    ENSEMBL Gene Tree for MYBL1 (if available)
    TreeFam Gene Tree for MYBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYBL1 gene
    MYBL22  MYB2  SNAPC42  
    3 SIMAP similar genes for MYBL1 using alignment to 3 protein entries:     MYBA_HUMAN (see all proteins):
    c-myb    MYB    MYBL2

    MYBL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYBL1 (see all 831)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432643771,2
    C--67474075(+) TTCAAC/G/TGTGGA 2 -- ds50010--------
    rs1466730101,2
    --67474092(+) TGATTA/GCTCAG 2 -- ds50010--------
    rs1876291981,2
    --67474172(+) GGAAAA/TCTGCT 2 -- ds50010--------
    rs1921432771,2
    --67474312(+) AGAGTC/TCTAAA 2 -- ds50010--------
    rs1850438201,2
    --67474349(+) GTTAAG/TTCTCT 2 -- ds50010--------
    rs1894040281,2
    --67474427(+) CAGATA/GCTTTA 2 -- ut310--------
    rs1927167601,2
    --67474641(+) AAGAAA/GCTCAG 2 -- ut310--------
    rs1402445771,2
    --67474803(+) TATTAC/TCATTT 2 -- ut310--------
    rs1841836921,2
    --67474908(+) AAGGGA/CTACAT 2 -- ut310--------
    rs1126304071,2
    C,F--67474976(+) ATCCAG/CTATGA 2 -- ut312Minor allele frequency- C:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for MYBL1 (67474410 - 67526482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYBL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv994614CNV Loss20482838
    nsv831346CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159405    OMIM disorders: --

    9 diseases for MYBL1:    
    About MalaCards
    burkitt's lymphoma    leiomyoma    lymphoblastic leukemia    chronic lymphocytic leukemia
    b-cell lymphomas    neuroblastoma    hypertension    leukemia
    malaria


    MYBL1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MYBL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 53.7 5 8021494 (2), 8634438 (2), 9510180 (1)
    hyperplasia 3.51 5 9096377 (3), 10910917 (1)
    tumors 0 4 10910917 (2), 8634438 (1)
    lymphoma 0 1 10692454 (1)

    Genetic Association Database (GAD): MYBL1

    Export disorders for MYBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYBL1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with MYBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA binding and transactivation activity of A-myb, a C-myb-related gene. (PubMed id 7987850)1, 2, 9 Ma X.P. and Calabretta B. (Cancer Res. 1994)
    2. The human A-myb protein is a strong activator of transcription. (PubMed id 8058310)1, 2, 9 Golay J.... Introna M. (Oncogene 1994)
    3. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (Mol. Cell 2007)
    4. Isolation of human cDNA clones of myb-related genes, A-myb and B- myb. (PubMed id 3060855)1, 2 Nomura N....Ishizaki R. (Nucleic Acids Res. 1988)
    5. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. (PubMed id 16055500)1, 9 Kurahashi T....Ishii S. (Mol. Biol. Cell 2005)
    6. Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. (PubMed id 9210395)1, 9 Facchinetti V....Golay J. (Biochem. J. 1997)
    7. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. (PubMed id 7821437)1, 9 Takahashi T....Ishii S. (FEBS Lett. 1995)
    8. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PubMed id 10660576)1, 9 Ying G.G....Golay J. (J. Biol. Chem. 2000)
    9. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. (PubMed id 23633565)1 Ramkissoon L.A....Ligon K.L. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4603 HGNC: 7547 AceView: MYBL1 Ensembl:ENSG00000185697 euGenes: HUgn4603
    ECgene: MYBL1 Kegg: 4603 H-InvDB: MYBL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYBL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYBL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYBL1 gene:
    Search GeneIP for patents involving MYBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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