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Aliases for MYBL1 Gene

Aliases for MYBL1 Gene

  • MYB Proto-Oncogene Like 1 2 3
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1 2 3 5
  • Myb-Like Protein 1 3 4
  • A-MYB 3 4
  • AMYB 3 4

External Ids for MYBL1 Gene

Previous GeneCards Identifiers for MYBL1 Gene

  • GC08M067414
  • GC08M067197
  • GC08M067524
  • GC08M067526
  • GC08M067636
  • GC08M067474
  • GC08M062964

Summaries for MYBL1 Gene

GeneCards Summary for MYBL1 Gene

MYBL1 (MYB Proto-Oncogene Like 1) is a Protein Coding gene. Diseases associated with MYBL1 include burkitt lymphoma. Among its related pathways are HTLV-I infection and Gene Expression. GO annotations related to this gene include chromatin binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is SNAPC4.

UniProtKB/Swiss-Prot for MYBL1 Gene

  • Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL1 Gene

Genomics for MYBL1 Gene

Regulatory Elements for MYBL1 Gene

Enhancers for MYBL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYBL1 on UCSC Golden Path with GeneCards custom track

Promoters for MYBL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYBL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYBL1 Gene

Chromosome:
8
Start:
66,562,175 bp from pter
End:
66,614,247 bp from pter
Size:
52,073 bases
Orientation:
Minus strand

Genomic View for MYBL1 Gene

Genes around MYBL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYBL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL1 Gene

Proteins for MYBL1 Gene

  • Protein details for MYBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10243-MYBA_HUMAN
    Recommended name:
    Myb-related protein A
    Protein Accession:
    P10243
    Secondary Accessions:
    • E7EW29
    • Q495F9

    Protein attributes for MYBL1 Gene

    Size:
    752 amino acids
    Molecular mass:
    85887 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Alternative splice isoforms for MYBL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL1 Gene

Proteomics data for MYBL1 Gene at MOPED

Post-translational modifications for MYBL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYBL1 Gene

No data available for DME Specific Peptides for MYBL1 Gene

Domains & Families for MYBL1 Gene

Gene Families for MYBL1 Gene

Protein Domains for MYBL1 Gene

Graphical View of Domain Structure for InterPro Entry

P10243

UniProtKB/Swiss-Prot:

MYBA_HUMAN :
  • Contains 3 HTH myb-type DNA-binding domains.
Domain:
  • Contains 3 HTH myb-type DNA-binding domains.
genes like me logo Genes that share domains with MYBL1: view

Function for MYBL1 Gene

Molecular function for MYBL1 Gene

GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog-like 1
UniProtKB/Swiss-Prot Function:
Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

Gene Ontology (GO) - Molecular Function for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 7987850
genes like me logo Genes that share ontologies with MYBL1: view
genes like me logo Genes that share phenotypes with MYBL1: view

Animal Models for MYBL1 Gene

MGI Knock Outs for MYBL1:

Animal Model Products

miRNA for MYBL1 Gene

miRTarBase miRNAs that target MYBL1
Targeted motifs for MYBL1 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL1
  • Consensus sequence: TGGCAGTTGG Submotif: canonical Cell Type: Testes GEO ID: GSE44588

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL1 Gene

Localization for MYBL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYBL1 Gene COMPARTMENTS Subcellular localization image for MYBL1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for MYBL1 Gene

Pathways & Interactions for MYBL1 Gene

genes like me logo Genes that share pathways with MYBL1: view

Pathways by source for MYBL1 Gene

1 BioSystems pathway for MYBL1 Gene
1 KEGG pathway for MYBL1 Gene

Gene Ontology (GO) - Biological Process for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IDA 7987850
GO:0034587 piRNA metabolic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated NAS 8058310
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 7987850
genes like me logo Genes that share ontologies with MYBL1: view

No data available for SIGNOR curated interactions for MYBL1 Gene

Drugs & Compounds for MYBL1 Gene

(1) Drugs for MYBL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MYBL1: view

Transcripts for MYBL1 Gene

Unigene Clusters for MYBL1 Gene

V-myb myeloblastosis viral oncogene homolog (avian)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2: -

Relevant External Links for MYBL1 Gene

GeneLoc Exon Structure for
MYBL1
ECgene alternative splicing isoforms for
MYBL1

Expression for MYBL1 Gene

mRNA expression in normal human tissues for MYBL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYBL1 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for MYBL1 Gene

This gene is overexpressed in Cerebrospinal fluid (50.5) and Monocytes (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYBL1 Gene



SOURCE GeneReport for Unigene cluster for MYBL1 Gene Hs.445898

mRNA Expression by UniProt/SwissProt for MYBL1 Gene

P10243-MYBA_HUMAN
Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
genes like me logo Genes that share expression patterns with MYBL1: view

Protein tissue co-expression partners for MYBL1 Gene

Primer Products

In Situ Assay Products

Orthologs for MYBL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYBL1 35
  • 93.4 (n)
  • 93.62 (a)
MYBL1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYBL1 35
  • 94.05 (n)
  • 94.14 (a)
MYBL1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybl1 35
  • 90.95 (n)
  • 92.68 (a)
Mybl1 16
Mybl1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYBL1 35
  • 99.78 (n)
  • 99.73 (a)
MYBL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mybl1 35
  • 90.08 (n)
  • 92.52 (a)
oppossum
(Monodelphis domestica)
Mammalia MYBL1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYBL1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYBL1 35
  • 78.78 (n)
  • 79.76 (a)
MYBL1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYBL1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mybl1 35
  • 67.14 (n)
  • 62.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia xamyb 35
zebrafish
(Danio rerio)
Actinopterygii mybl1 35
  • 58.09 (n)
  • 57.26 (a)
mybl1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 14 (a)
OneToMany
Species with no ortholog for MYBL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBL1 Gene

ENSEMBL:
Gene Tree for MYBL1 (if available)
TreeFam:
Gene Tree for MYBL1 (if available)

Paralogs for MYBL1 Gene

Paralogs for MYBL1 Gene

(3) SIMAP similar genes for MYBL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYBL1: view

Variants for MYBL1 Gene

Sequence variations from dbSNP and Humsavar for MYBL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2358000 -- 66,582,222(+) agctc(C/T)acact intron-variant
rs2454668 -- 66,576,926(-) tttgc(A/G)tatat intron-variant
rs7830436 -- 66,593,858(+) Gggcc(A/G)ggtac intron-variant
rs7844944 -- 66,589,617(+) ctgga(A/G)ccaca intron-variant
rs9773272 -- 66,579,014(+) tcata(A/G)atggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYBL1 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv994614 CNV Loss 20482838

Variation tolerance for MYBL1 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYBL1 Gene

HapMap Linkage Disequilibrium report
MYBL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL1 Gene

Disorders for MYBL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYBL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • burkitt's lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search MYBL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYBL1

Genetic Association Database (GAD)
MYBL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYBL1
genes like me logo Genes that share disorders with MYBL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYBL1 Gene

Publications for MYBL1 Gene

  1. DNA binding and transactivation activity of A-myb, a C-myb-related gene. (PMID: 7987850) Ma X.P. … Calabretta B. (Cancer Res. 1994) 3 4 23 67
  2. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. (PMID: 16055500) Kurahashi T. … Ishii S. (Mol. Biol. Cell 2005) 3 23
  3. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PMID: 10660576) Ying G.G. … Golay J. (J. Biol. Chem. 2000) 3 23
  4. Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. (PMID: 9210395) Facchinetti V. … Golay J. (Biochem. J. 1997) 3 23
  5. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. (PMID: 7821437) Takahashi T. … Ishii S. (FEBS Lett. 1995) 3 23

Products for MYBL1 Gene

Sources for MYBL1 Gene

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