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Aliases for MYBL1 Gene

Aliases for MYBL1 Gene

  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1 2 3
  • Myb-Like Protein 1 3 4
  • A-MYB 3 4
  • AMYB 3 4
  • Myb-Related Protein A 3

External Ids for MYBL1 Gene

Summaries for MYBL1 Gene

GeneCards Summary for MYBL1 Gene

MYBL1 (V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1) is a Protein Coding gene. Among its related pathways are IL4-mediated signaling events and HTLV-I infection. GO annotations related to this gene include chromatin binding. An important paralog of this gene is SNAPC4.

UniProtKB/Swiss-Prot for MYBL1 Gene

  • Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL1 Gene

Genomics for MYBL1 Gene

Genomic Location for MYBL1 Gene

Start:
66,562,175 bp from pter
End:
66,614,247 bp from pter
Size:
52,073 bases
Orientation:
Minus strand

Genomic View for MYBL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL1 Gene

Regulatory Elements for MYBL1 Gene

Proteins for MYBL1 Gene

  • Protein details for MYBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10243-MYBA_HUMAN
    Recommended name:
    Myb-related protein A
    Protein Accession:
    P10243
    Secondary Accessions:
    • E7EW29
    • Q495F9

    Protein attributes for MYBL1 Gene

    Size:
    752 amino acids
    Molecular mass:
    85887 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Alternative splice isoforms for MYBL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL1 Gene

Proteomics data for MYBL1 Gene at MOPED

Post-translational modifications for MYBL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys79, Lys92, Lys104, and Lys166

Other Protein References for MYBL1 Gene

No data available for DME Specific Peptides for MYBL1 Gene

Domains for MYBL1 Gene

UniProtKB/Swiss-Prot:

MYBA_HUMAN
Domain:
  • Contains 3 HTH myb-type DNA-binding domains.:
    • P10243
genes like me logo Genes that share domains with MYBL1: view

No data available for Gene Families for MYBL1 Gene

Function for MYBL1 Gene

Molecular function for MYBL1 Gene

GENATLAS Biochemistry: avian myeloblastosis viral (v-myb) oncogene homolog-like 1
UniProtKB/Swiss-Prot Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells

Gene Ontology (GO) - Molecular Function for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7987850
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 7987850
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MYBL1: view
genes like me logo Genes that share phenotypes with MYBL1: view

Animal Models for MYBL1 Gene

MGI Knock Outs for MYBL1:
Targeting motifs for MYBL1 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL1
  • Consensus sequence: TGGCAGTTGG Submotif: canonical Cell Type: Testes GeoId: GSE44588

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for MYBL1 Gene

Localization for MYBL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYBL1 Gene COMPARTMENTS Subcellular localization image for MYBL1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8058310
genes like me logo Genes that share ontologies with MYBL1: view

Pathways for MYBL1 Gene

genes like me logo Genes that share pathways with MYBL1: view

Pathways by source for MYBL1 Gene

1 BioSystems pathway for MYBL1 Gene
1 KEGG pathway for MYBL1 Gene

Gene Ontology (GO) - Biological Process for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0010467 gene expression TAS --
GO:0034587 piRNA metabolic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated NAS 8058310
genes like me logo Genes that share ontologies with MYBL1: view

Compounds for MYBL1 Gene

(1) Novoseek inferred chemical compound relationships for MYBL1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 16 2
genes like me logo Genes that share compounds with MYBL1: view

Transcripts for MYBL1 Gene

Unigene Clusters for MYBL1 Gene

V-myb myeloblastosis viral oncogene homolog (avian)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2: -

Relevant External Links for MYBL1 Gene

GeneLoc Exon Structure for
MYBL1
ECgene alternative splicing isoforms for
MYBL1

Expression for MYBL1 Gene

mRNA expression in normal human tissues for MYBL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYBL1 Gene

This gene is overexpressed in Artery - Tibial (6.3) and Whole Blood (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYBL1 Gene

SOURCE GeneReport for Unigene cluster for MYBL1 Gene Hs.445898

mRNA Expression by UniProt/SwissProt for MYBL1 Gene

P10243-MYBA_HUMAN
Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro
genes like me logo Genes that share expressions with MYBL1: view

Orthologs for MYBL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBL1 36
  • 99.78 (n)
  • 99.73 (a)
MYBL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYBL1 36
  • 93.4 (n)
  • 93.62 (a)
MYBL1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYBL1 36
  • 94.05 (n)
  • 94.14 (a)
MYBL1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybl1 36
  • 90.95 (n)
  • 92.68 (a)
Mybl1 16
Mybl1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBL1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYBL1 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mybl1 36
  • 90.08 (n)
  • 92.52 (a)
chicken
(Gallus gallus)
Aves MYBL1 36
  • 78.78 (n)
  • 79.76 (a)
MYBL1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYBL1 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xamyb 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mybl1 36
  • 67.14 (n)
  • 62.76 (a)
zebrafish
(Danio rerio)
Actinopterygii mybl1 36
  • 58.09 (n)
  • 57.26 (a)
mybl1 37
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 37
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 37
  • 14 (a)
OneToMany
Species with no ortholog for MYBL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBL1 Gene

ENSEMBL:
Gene Tree for MYBL1 (if available)
TreeFam:
Gene Tree for MYBL1 (if available)

Paralogs for MYBL1 Gene

Paralogs for MYBL1 Gene

Selected SIMAP similar genes for MYBL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYBL1: view

Variants for MYBL1 Gene

Sequence variations from dbSNP and Humsavar for MYBL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1042733 -- 66,580,256(-) GATGA(A/G)AATCA reference, synonymous-codon
rs1392150 -- 66,613,602(-) GACCC(A/G)CTCCG upstream-variant-2KB
rs1988271 -- 66,610,397(-) AAAAC(C/T)TAAGA intron-variant
rs2358000 -- 66,582,222(+) agctc(C/T)acact intron-variant
rs2454668 -- 66,576,926(-) tttgc(A/G)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYBL1 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv994614 CNV Loss 20482838

Relevant External Links for MYBL1 Gene

HapMap Linkage Disequilibrium report
MYBL1

Disorders for MYBL1 Gene

(4) Novoseek inferred disease relationships for MYBL1 Gene

Disease -log(P) Hits PubMed IDs
burkitt lymphoma 53.7 5
hyperplasia 3.51 4
tumors 0 3
lymphoma 0 1

Relevant External Links for MYBL1

Genetic Association Database (GAD)
MYBL1
genes like me logo Genes that share disorders with MYBL1: view

No data available for UniProtKB/Swiss-Prot for MYBL1 Gene

Publications for MYBL1 Gene

  1. The human A-myb protein is a strong activator of transcription. (PMID: 8058310) Golay J. … Introna M. (Oncogene 1994) 3 4 23
  2. DNA binding and transactivation activity of A-myb, a C-myb-related gene. (PMID: 7987850) Ma X.P. … Calabretta B. (Cancer Res. 1994) 3 4 23
  3. Isolation of human cDNA clones of myb-related genes, A-myb and B- myb. (PMID: 3060855) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1988) 3 4
  4. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. (PMID: 16055500) Kurahashi T. … Ishii S. (Mol. Biol. Cell 2005) 3 23
  5. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PMID: 10660576) Ying G.G. … Golay J. (J. Biol. Chem. 2000) 3 23

Products for MYBL1 Gene

Sources for MYBL1 Gene

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