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MYBL1 Gene

protein-coding   GIFtS: 57

GC08M067636
v-myb myeloblastosis viral oncogene homolog (avian)-like 1
(Previous name: v-myb avian myeloblastosis viral oncogene homolog-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
A-MYB 2
A-Myb 3
A-myb 1
AMYB 1, 2, 3
MGC120059 2
MGC120061 2
Descriptions
v-myb avian myeloblastosis viral oncogene homolog-like 1 1, 2
v-myb myeloblastosis viral oncogene homolog (avian)-like 1 2
External Ids
HGNC: 75471
Entrez Gene: 46032
UniProtKB: P102433
Ensembl: ENSG000001856977
Search outside databases for aliases for MYBL1 gene

Previous GC identifers: GC08M066596 GC08M067414 GC08M067197 GC08M067524 GC08M067526

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the
sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of
neurogenic, spermatogenic and B-lymphoid cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MYBL1 gene  

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q22

MYBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067636:     (about GC identifiers)

Start:
67,636,968 bp from pter
End:
67,693,680 bp from pter
Size:
56,713 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 (See protein sequence)
Recommended Name: Myb-related protein A  
Size: 752 amino acids; 85887 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5,
LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in
quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when
LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2
Subcellular location: Nucleus

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001073885.1  NP_001138227.1  


    ENSEMBL proteins: 
    ENSP00000332150 ENSP00000382469 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (v-Myb)
    Human Recombinant Proteins from Abnova (MYBL1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS8058310
    GO:0005730NOT nucleolus IDA18029348
    About this table

    Antibodies for MYBL1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MYBL1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (v-Myb), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MYBL1)
    Novus Biologicals Antibodies for MYBL1

    Assays for MYBL1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR001005 SANT_DNA-bd
     IPR014778 Myb_DNA-bd
     IPR012642 Trans_reg_Wos2-domain
     IPR015395 C-myb_C
     IPR012287 Homeodomain-rel


       GeneDecks  MYBL1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P10243

    ProtoNet protein and cluster: P10243

    2 Blocks protein families:
    IPB001005 Myb DNA-binding domain
    IPB012642 Mitotic Wos2


    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Similarity: Contains 3 HTH myb-type DNA-binding domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MYBL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MYBL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): XM_933454

                  Applied Biosystems Silencer® siRNAs for MYBL1

                  Sigma-Aldrich siRNA for MYBL1  
                         Sigma-Aldrich shRNA Panels and shRNA for MYBL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080416
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080416
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001080416 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001080416

    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the
    sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of
    neurogenic, spermatogenic and B-lymphoid cells

    Genatlas biochemistry entry for MYBL1:
    avian myeloblastosis viral (v-myb) oncogene homolog-like 1

    6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mybl1):

    endocrine/exocrine glandgrowth/sizehematopoietic systemimmune systemnormal
    reproductive system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0016563 transcription activator activity NAS8058310
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MYBL1 


    5/10 Interacting proteins for MYBL1 (ENSP000003321503) via UniProtKB, MINT, and/or STRING (see all 10 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLENSP000003181953STRING (score=.968)
    IGHEENSP000003749823STRING (score=.914)
    BCL2ENSP000003296233STRING (score=.905)
    HIPK2ENSP000002635513STRING (score=.895)
    AMY1AENSP000003073723STRING (score=.718)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MYBL1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MYBL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MYBL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): XM_933454

                  Sigma-Aldrich siRNA for MYBL1  
                         Sigma-Aldrich shRNA Panels and shRNA for MYBL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    REFSEQ mRNAs for MYBL1 gene (2 alternative transcripts): 

    NM_001080416.2   NM_001144755.1   


                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001080416
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001080416
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001080416 

    Additional cDNA sequence: 

    AK308490.1 BC032233.1 BC046930.1 BC069252.1 BC101186.1 BC101187.2 BC101188.1 S75881.1 
    X13294.1 X66087.1 

    7 DOTS entries:

    DT.413624  DT.411757  DT.99932314  DT.40125974  DT.100685936  DT.95363382  DT.99972691 

    24/92 AceView cDNA sequences (see all 92 ):

    AI869031 BF512152 BC032233 AL135299 AW274569 BC069252 AA504350 BQ573952 
    BQ424925 BF513374 AA768961 AA731205 CF137306 BC046930 AA911236 X13294 
    AA827864 AA747541 AA830717 AA687113 H13336 CN482561 CB961779 BM456292 

    highest scoring ESTs for MYBL1:

    S75881 X13294 X66087 AA235963 AA236996 AA251256 AA459003 AA459223 AA465682 AA482279 

    Unigene Cluster for MYBL1:

    V-myb myeloblastosis viral oncogene homolog (avian)-like 1
    Hs.445898  [show with all ESTs]
    Unigene Representative Sequence: NM_001080416


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                
    SP2:                                                                                -               

    About this scheme

    ECgene alternative splicing isoforms for MYBL1

    2 Ensembl transcripts including schematic representations:
    ENST00000331406  ENST00000399555  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MYBL1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MYBL1

    1 / 2 / 3

    7 probe-sets matching MYBL1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    160043_at2, 3 U95-A 1 1.00 1.00 0.96 0.78 X66087 0.80 1.00 0.91 1

    1465_s_at2, 3 U95-A 1 1.00 1.00 0.83 0.33 S75881 0.80 1.00 0.91 1
    90468_at2, 3 U95-E 3 0.81 0.27 0.95 1.23 AI539459 0.60 0.75 0.68 1

    213906_at2, 3 U133-A 1 1.00 1.00 -- -- AW592266 0.60 1.00 0.82 1

    231268_at2, 3 U133-B 3 0.82 0.27 -- -- AI539459 0.60 0.75 0.68 1

    213906_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    231268_at2 U133Plus2 3 0.82 0.27 -- -- -- -- -- -- --
    GeneDecks  MYBL1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAAACTGACT

    SOURCE GeneReport for Unigene cluster: Hs.445898

    Expression variation in blood from EXPOLDB for MYBL1

    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MYBL1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MYBL11   -- v-myb myeloblastosis viral oncogene homolog (avian)-like more 94.05(n)
    94.14(a)
    486979  XM_544108.2  XP_544108.2 
    cow
    (Bos taurus)
    MYBL11   -- v-myb myeloblastosis viral oncogene homolog (avian)-like more 89.37(n)
    88.7(a)
    338034  NM_176635.2  NP_788808.1 
    rat
    (Rattus norvegicus)
    Mybl11   -- myeloblastosis oncogene-like 1 90.1(n)
    92.54(a)
    297783  XM_232620.4  XP_232620.3 
    mouse
    (Mus musculus)
    Mybl11, 5 1 (3.00 cM)5
    myeloblastosis oncogene-like 11, 5 90.95(n)1
    92.68(a)1
    178641  NM_008651.21  NP_032677.21 
     BC1019455  BC1035335  (see all 9)
    chicken
    (Gallus gallus)
    MYBL11   -- myeloblastosis oncogene-like 1 78.78(n)
    79.76(a)
    396158  NM_205232.1  NP_990563.1 
    About this table        Species with no ortholog for MYBL1

    ENSEMBL Gene Tree for MYBL1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MYBL1 gene
    MYBL22  MYB2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/127 NCBI SNPs in MYBL1 are shown (see all 127 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs13921501,2
    F67688391(-) GACCCA/GCTCCG 1 -- ng311Minor allele frequency- G:0.49MN 184
    --
    rs119872541,2
    A67689417(+) gtctcA/Gctcta 1 -- ng310--------
    --
    rs23580001,2
    A,C,F,H67657011(+) agctcT/Cacact 1 -- int14Minor allele frequency- C:0.12EU EA WA 418
    rs119903311,2
    A,C,F,H67655245(+) AAAAAC/TATAGT 1 -- int14Minor allele frequency- T:0.13EU EA WA 418
    rs70087401,2
    A,C,F,H67645279(+) ATGTTC/GACCAA 1 -- int17Minor allele frequency- G:0.13EU EA WA NA 560
    rs69822021,2
    A,F,H67677838(+) cTGGAA/GCTATA 1 -- int13Minor allele frequency- G:0.03EU EA 288
    rs69869401,2
    A,F,H67678233(+) ACACTG/ATTGTG 1 -- int14Minor allele frequency- A:0.13EU EA WA 418
    rs46410511,2
    C,F,H67662785(+) TTGCAA/GAGCAA 1 -- int17Minor allele frequency- G:0.03EU EA WA NA 560
    rs119933541,2
    C,F,H67681140(+) CGTGCA/GTAGGC 1 -- int17Minor allele frequency- G:0.10EU EA WA NA 554
    rs105043981,2
    C,F,H67649469(+) ACTGTT/CGCCTT 1 -- int121Minor allele frequency- C:0.13NS EU EA WA NA 1580
    About this table

    HapMap Linkage Disequilibrium images for MYBL1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 159405

    4 Novoseek disease relationships for MYBL1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 55.46 5 8021494 (2), 8634438 (2), 9510180 (1)
    hyperplasia 5.63 5 9096377 (3), 10910917 (1)
    tumors 0.00 4 10910917 (2), 8634438 (1)
    lymphoma 0.00 1 10692454 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/44 PubMed articles for MYBL1 gene (see all 44 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4603 HGNC: 7547 AceView: MYBL1 Ensembl:ENSG00000185697 euGenes: HUgn4603
    ECgene: MYBL1 H-InvDB: MYBL1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MYBL1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MYBL1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for MYBL1 Antibodies for MYBL1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MYBL1 Browse small molecules at Sigma-Aldrich
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