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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYBL1 Gene

protein-coding   GIFtS: 54
GCID: GC08M067474

V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 11 2     Myb-Related Protein A2
Myb-Like Protein 12 3     V-Myb Myeloblastosis Viral Oncogene Homolog-Like 12
AMYB2 3     A-Myb3
A-MYB2     

External Ids:    HGNC: 75471   Entrez Gene: 46032   Ensembl: ENSG000001856977   OMIM: 1594055   UniProtKB: P102433   

Export aliases for MYBL1 gene to outside databases

Previous GC identifers: GC08M066596 GC08M067414 GC08M067197 GC08M067524 GC08M067526 GC08M067636 GC08M062964


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYBL1 Gene: 
MYBL1 (v-myb avian myeloblastosis viral oncogene homolog-like 1) is a protein-coding gene. Diseases associated with MYBL1 include burkitt's lymphoma, and leiomyoma. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is MYBL2.

UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence
5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and
B-lymphoid cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYBL1 gene promoter:
         HOXA9   HOXA9B   FOXD3   Meis-1b   POU2F1   GATA-6   POU2F1a   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MYBL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q22

MYBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYBL1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067474:  view genomic region     (about GC identifiers)

Start:
67,474,410 bp from pter      End:
67,526,482 bp from pter
Size:
52,073 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 (See protein sequence)
Recommended Name: Myb-related protein A  
Size: 752 amino acids; 85887 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37,
LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it
represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a
subcomplex that binds to MYBL2
Subcellular location: Nucleus
Secondary accessions: E7EW29 Q495F9
Alternative splicing: 2 isoforms:  P10243-1   P10243-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYBL1: NX_P10243

Explore proteomics data for MYBL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10243

  • MYBL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYBL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001073885.1  NP_001138227.1  

    ENSEMBL proteins: 
     ENSP00000429633   ENSP00000428265   ENSP00000428011  

    Human Recombinant Protein Products for MYBL1: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MYBL1
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    Novus Biologicals MYBL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYBL1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8058310

    MYBL1 for ontologies           About GeneDecksing



    MYBL1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MYBL1 

    Assay Products for MYBL1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MYBL1 
    Cloud-Clone Corp. CLIAs for MYBL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR015395 C-myb_C
     IPR017930 Myb_dom
     IPR009057 Homeodomain-like
     IPR012642 Tscrpt_reg_Wos2-domain

    Graphical View of Domain Structure for InterPro Entry P10243

    ProtoNet protein and cluster: P10243

    2 Blocks protein domains:
    IPB001005 Myb DNA-binding domain
    IPB012642 Mitotic Wos2


    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Similarity: Contains 3 HTH myb-type DNA-binding domains


    MYBL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYBA_HUMAN, P10243
    Function: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence
    5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and
    B-lymphoid cells

         Genatlas biochemistry entry for MYBL1:
    avian myeloblastosis viral (v-myb) oncogene homolog-like 1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
         
    MYBL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYBL1:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mybl1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  normal  reproductive system 

    MYBL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mybl1tm1Epr for MYBL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYBL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYBL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYBL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYBL1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYBL1
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate MYBL1 (see all 72):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-146a hsa-miR-15a hsa-miR-4272 hsa-miR-200a hsa-miR-138-2* hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYBL1
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    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYBL1
    Sirion Biotech Customized adenovirus for overexpression of MYBL1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of MYBL1 

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    Search LifeMap BioReagents cell lines for MYBL1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYBL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1IL4-mediated signaling events
    IL4-mediated signaling events
    2HTLV-I infection
    HTLV-I infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MYBL1
        IL4-mediated signaling events


    1         Kegg Pathway  (Kegg details for MYBL1):
        HTLV-I infection


    MYBL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYBL1

    5/14 Interacting proteins for MYBL1 (P102433) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8L2Q9H6S33I2D: score=4 
    MCCP235083I2D: score=3 
    LIN37Q96GY33I2D: score=2 
    LIN54Q6MZP73I2D: score=2 
    LIN9Q5TKA13I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0045893positive regulation of transcription, DNA-dependent NAS8058310

    MYBL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYBL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYBL1 (MYBA)

    1 Novoseek inferred chemical compound relationship for MYBL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 16 2 15879465 (2)

    Search CenterWatch for drugs/clinical trials and news about MYBL1 / MYBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYBL1 gene (2 alternative transcripts): 
    NM_001080416.2  NM_001144755.1  

    Unigene Cluster for MYBL1:

    V-myb myeloblastosis viral oncogene homolog (avian)-like 1
    Hs.445898  [show with all ESTs]
    Unigene Representative Sequence: NM_001080416
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522677(uc003xwj.3 uc003xwl.3 uc003xwk.3) ENST00000517885
    ENST00000524176 ENST00000522419 ENST00000518079 ENST00000523304(uc003xwm.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYBL1
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate MYBL1 (see all 72):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-146a hsa-miR-15a hsa-miR-4272 hsa-miR-200a hsa-miR-138-2* hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYBL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYBL1
    Clone
    Products:
         
    OriGene clones in human, mouse for MYBL1 (see all 12)
    OriGene ORF clones in mouse, rat for MYBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYBL1 (NM_001080416)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYBL1
    Sirion Biotech Customized lentivirus for stable overexpression of MYBL1 
                         Customized lentivirus expression plasmids for stable overexpression of MYBL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYBL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYBL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYBL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYBL1

    Additional mRNA sequence: 

    AK308490.1 BC032233.1 BC046930.1 BC069252.1 BC101186.1 BC101187.2 BC101188.1 S75881.1 
    X13294.1 X66087.1 

    7 DOTS entries:

    DT.413624  DT.411757  DT.99932314  DT.40125974  DT.100685936  DT.95363382  DT.99972691 

    24/92 AceView cDNA sequences (see all 92):

    AA747541 BF513374 BC069252 AA911236 BQ424925 AA827864 BQ573952 BF512152 
    AA830717 X13294 AA768961 AA731205 CF137306 AA504350 BC032233 AA687113 
    AI869031 AW274569 AL135299 BC046930 BM456292 AW340071 S75881 H13336 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                
    SP2:                                                                                -               


    ECgene alternative splicing isoforms for MYBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYBL1 expression in normal human tissues (normalized intensities)      MYBL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACTGACT
    MYBL1 Expression
    About this image


    MYBL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose/nasal cavity   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   
     
     Eye (Sensory Organs)
             Retina
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus

    See MYBL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYBL1

    SOURCE GeneReport for Unigene cluster: Hs.445898

    UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243
    Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro

        SABiosciences Expression via Pathway-Focused PCR Array including MYBL1: 
              Lymphoma in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYBL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYBL1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mybl11 , 5 myeloblastosis oncogene-like 11, 5 90.95(n)1
    92.68(a)1
      1 (2.08 cM)5
    178641  NM_008651.21  NP_032677.21 
     96674155 
    chicken
    (Gallus gallus)
    Aves MYBL11 v-myb myeloblastosis viral oncogene homolog (avian)-like more 78.78(n)
    79.76(a)
      396158  NM_205232.1  NP_990563.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYBL16
    v-myb myeloblastosis viral oncogene homolog (avian...
    78(a)
    1 ↔ 1
    4(30873961-30901920)
    African clawed frog
    (Xenopus laevis)
    Amphibia xamyb2 xamyb protein 76.43(n)    X72620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mybl11 v-myb myeloblastosis viral oncogene homolog (avian)-like more 58.73(n)
    57.89(a)
      558540  XM_681770.5  XP_686862.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myb1 Myb oncogene-like 47.49(n)
    41.68(a)
      32543  NM_078615.3  NP_511170.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BAS16
    Myb-related transcription factor involved in regul...
    12(a)
    1 → many
    XI(635851-638286)


    ENSEMBL Gene Tree for MYBL1 (if available)
    TreeFam Gene Tree for MYBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYBL1 gene
    MYBL22  MYB2  SNAPC42  
    3 SIMAP similar genes for MYBL1 using alignment to 3 protein entries:     MYBA_HUMAN (see all proteins):
    c-myb    MYB    MYBL2

    MYBL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/831 SNPs in MYBL1 are shown (see all 831)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432643771,2
    C--67474075(+) TTCAAC/G/TGTGGA 2 -- ds50010--------
    rs1466730101,2
    --67474092(+) TGATTA/GCTCAG 2 -- ds50010--------
    rs1876291981,2
    --67474172(+) GGAAAA/TCTGCT 2 -- ds50010--------
    rs1921432771,2
    --67474312(+) AGAGTC/TCTAAA 2 -- ds50010--------
    rs1850438201,2
    --67474349(+) GTTAAG/TTCTCT 2 -- ds50010--------
    rs1894040281,2
    --67474427(+) CAGATA/GCTTTA 2 -- ut310--------
    rs1927167601,2
    --67474641(+) AAGAAA/GCTCAG 2 -- ut310--------
    rs1402445771,2
    --67474803(+) TATTAC/TCATTT 2 -- ut310--------
    rs1841836921,2
    --67474908(+) AAGGGA/CTACAT 2 -- ut310--------
    rs1126304071,2
    C,F--67474976(+) ATCCAG/CTATGA 2 -- ut312Minor allele frequency- C:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for MYBL1 (67474410 - 67526482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYBL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv994614CNV Loss20482838
    nsv831346CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 159405    OMIM disorders: --

    9 diseases for MYBL1:    About MalaCards
    burkitt's lymphoma    leiomyoma    acute lymphoblastic leukemia    chronic lymphocytic leukemia
    lymphoblastic leukemia    hypertension    b-cell lymphomas    neuroblastoma
    leukemia


    MYBL1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MYBL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 53.7 5 8021494 (2), 8634438 (2), 9510180 (1)
    hyperplasia 3.51 5 9096377 (3), 10910917 (1)
    tumors 0 4 10910917 (2), 8634438 (1)
    lymphoma 0 1 10692454 (1)

    Genetic Association Database (GAD): MYBL1

    Export disorders for MYBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYBL1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with MYBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA binding and transactivation activity of A-myb, a C-myb-related gene. (PubMed id 7987850)1, 2, 9 Ma X.P. and Calabretta B. (1994)
    2. The human A-myb protein is a strong activator of transcription. (PubMed id 8058310)1, 2, 9 Golay J.... Introna M. (1994)
    3. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
    4. Isolation of human cDNA clones of myb-related genes, A-myb and B- myb. (PubMed id 3060855)1, 2 Nomura N....Ishizaki R. (1988)
    5. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. (PubMed id 16055500)1, 9 Kurahashi T....Ishii S. (2005)
    6. Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. (PubMed id 9210395)1, 9 Facchinetti V....Golay J. (1997)
    7. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. (PubMed id 7821437)1, 9 Takahashi T....Ishii S. (1995)
    8. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PubMed id 10660576)1, 9 Ying G.G....Golay J. (2000)
    9. Genomic analysis of diffuse pediatric low-grade glioma s identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. (PubMed id 23633565)1 Ramkissoon L.A....Ligon K.L. (2013)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4603 HGNC: 7547 AceView: MYBL1 Ensembl:ENSG00000185697 euGenes: HUgn4603
    ECgene: MYBL1 Kegg: 4603 H-InvDB: MYBL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYBL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYBL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYBL1 gene:
    Search GeneIP for patents involving MYBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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