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Aliases & Descriptions for MYBL1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases A-MYB 2 A-Myb 3 A-myb 1 AMYB 1 , 2 , 3 MGC120059 2 MGC120061 2
Descriptions v-myb avian myeloblastosis viral oncogene homolog-like 1 1 , 2 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 2
Search outside databases for aliases for MYBL1 genePrevious GC identifers: GC08M066596 GC08M067414 GC08M067197 GC08M067524 GC08M067526
Summaries for MYBL1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 Function : Strong transcriptional activator; DNA-binding protein that specifically recognize thesequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation ofneurogenic, spermatogenic and B-lymphoid cells
Genomic Location for MYBL1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MYBL1 gene Entrez Gene cytogenetic band: 8q22 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q22 MYBL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M067636:
(about GC identifiers )
Start:
67,636,968 bp from pter
End:
67,693,680 bp from pter
Size:
56,713 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000008.9 NT_008183.18 Proteins for MYBL1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 (See
protein sequence )Recommended Name: Myb-related protein A Size : 752 amino acids; 85887 Da
Subunit : Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5,LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists inquiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase whenLIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2
Subcellular location : Nucleus
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001073885.1 NP_001138227.1 ENSEMBL proteins: ENSP00000332150 ENSP00000382469 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MYBL1: Assays for MYBL1:
Protein
Domains/ Families for MYBL1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P10243 ProtoNet protein and cluster: P10243
2 Blocks protein families : IPB001005 Myb DNA-binding domain IPB012642 Mitotic Wos2 UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 Similarity : Contains 3 HTH myb-type DNA-binding domains
Gene Function for MYBL1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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RNAi Products ,
Clones , and
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Millipore ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9 ): XM_933454 Applied Biosystems Silencer ® siRNAs for MYBL1 Sigma-Aldrich siRNA for MYBL1 Sigma-Aldrich shRNA Panels and shRNA for MYBL1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001080416                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001080416                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001080416  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001080416 UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 Function : Strong transcriptional activator; DNA-binding protein that specifically recognize thesequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation ofneurogenic, spermatogenic and B-lymphoid cells
Genatlas biochemistry entry for MYBL1 :avian myeloblastosis viral (v-myb) oncogene homolog-like 1
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mybl1) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for MYBL1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MYBL1 5/10 Interacting proteins for MYBL1 (ENSP00000332150 3 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
NAS --
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Drugs & Compounds for MYBL1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for MYBL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9 ): XM_933454 Sigma-Aldrich siRNA for MYBL1 Sigma-Aldrich shRNA Panels and shRNA for MYBL1 Explore Sigma-Aldrich super-pooled esiRNAs
REFSEQ mRNAs for MYBL1 gene (2 alternative transcripts): NM_001080416.2 NM_001144755.1
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001080416                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001080416                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001080416  
Additional cDNA sequence: AK308490.1 BC032233.1 BC046930.1 BC069252.1 BC101186.1 BC101187.2 BC101188.1 S75881.1 X13294.1 X66087.1
7 DOTS entries : DT.413624 DT.411757 DT.99932314 DT.40125974 DT.100685936 DT.95363382 DT.99972691
24/92 AceView cDNA sequences (see all 92
):AI869031 BF512152 BC032233 AL135299 AW274569 BC069252 AA504350 BQ573952 BQ424925 BF513374 AA768961 AA731205 CF137306 BC046930 AA911236 X13294 AA827864 AA747541 AA830717 AA687113 H13336 CN482561 CB961779 BM456292
highest scoring ESTs for MYBL1 :S75881 X13294 X66087 AA235963 AA236996 AA251256 AA459003 AA459223 AA465682 AA482279
Unigene Cluster for MYBL1: V-myb myeloblastosis viral oncogene homolog (avian)-like 1 Hs.445898 [show with all ESTs ] Unigene Representative Sequence: NM_001080416 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b SP1 :                                 SP2 :                           -      
About this scheme ECgene alternative splicing isoforms for MYBL1 2 Ensembl transcripts including schematic representations : ENST00000331406
ENST00000399555
Expression for MYBL1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MYBL1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MYBL1 1 / 2 / 3
7 probe-sets matching MYBL1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAAACTGACTSOURCE GeneReport for Unigene cluster: Hs.445898 Expression variation in blood from EXPOLDB for MYBL1
UniProtKB/Swiss-Prot: MYBA_HUMAN, P10243 Tissue specificity : Expressed in a variety of lymphoid and solid tumor lines cultured in vitro
Orthologs for MYBL1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MYBL1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for MYBL1 ENSEMBL Gene Tree for MYBL1 Paralogs for MYBL1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MYBL1 gene MYBL2 2 MYB 2
SNPs/Variants for MYBL1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MYBL1 (up to first 250kb)
Disorders & Mutations for MYBL1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 159405 4 Novoseek disease relationships for MYBL1 gene
About this table
Medical News for MYBL1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MYBL1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/44 PubMed articles for MYBL1 gene (see all 44
): DNA binding and transactivation activity of A-myb, a C-myb-related gene. (PubMed id 7987850) 1, 3, 4 Ma X.P. and Calabretta B. (1994) The human A-myb protein is a strong activator of transcription. (PubMed id 8058310) 1, 3, 4 Golay J.... Introna M. (1994) Isolation of human cDNA clones of myb-related genes, A-myb and B- myb. (PubMed id 3060855) 3, 4 Nomura N....Ishizaki R. (1988) Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. (PubMed id 7821437) 1, 3 Takahashi T....Ishii S. (1995) Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PubMed id 10660576) 1, 3 Ying G.G....Golay J. (2000) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812) 4 Litovchick L.... DeCaprio J.A. (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Chromosome locations of the MYB related genes, AMYB and BMYB. (PubMed id 2065336) 3 Barletta C....Huebner K. (1991) A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase. (PubMed id 9111313) 1 Marhamati D.J....Sonenshein G.E. (1997)
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Genome Databases showing MYBL1
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and/or
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Specialized Databases showing MYBL1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MYBL1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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