Aliases for MYBBP1A Gene
External Ids for MYBBP1A Gene
Previous GeneCards Identifiers for MYBBP1A Gene
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for MYBBP1A Gene
MYBBP1A (MYB Binding Protein 1a) is a Protein Coding gene. Diseases associated with MYBBP1A include Brain Glioma. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Transcriptional activation of mitochondrial biogenesis. GO annotations related to this gene include poly(A) RNA binding and binding.
UniProtKB/Swiss-Prot for MYBBP1A Gene
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.