Aliases for MYBBP1A Gene
External Ids for MYBBP1A Gene
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for MYBBP1A Gene
MYBBP1A (MYB Binding Protein (P160) 1a) is a Protein Coding gene. Diseases associated with MYBBP1A include brain glioma. Among its related pathways are Energy Metabolism. GO annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot for MYBBP1A Gene
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.