Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYBBP1A Gene

Aliases for MYBBP1A Gene

  • MYB Binding Protein 1a 2 3 5
  • MYB Binding Protein (P160) 1a 2 3
  • P53-Activated Protein-2 2 3
  • P160 3 4
  • Myb-Binding Protein 1A 3
  • PAP2 3

External Ids for MYBBP1A Gene

Previous GeneCards Identifiers for MYBBP1A Gene

  • GC17M004867
  • GC17M004787
  • GC17M004393
  • GC17M004648
  • GC17M004388
  • GC17M004442
  • GC17M004331

Summaries for MYBBP1A Gene

Entrez Gene Summary for MYBBP1A Gene

  • This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for MYBBP1A Gene

MYBBP1A (MYB Binding Protein 1a) is a Protein Coding gene. Diseases associated with MYBBP1A include Brain Glioma. Among its related pathways are Circadian rythm related genes and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for MYBBP1A Gene

  • May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.

Gene Wiki entry for MYBBP1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBBP1A Gene

Genomics for MYBBP1A Gene

Regulatory Elements for MYBBP1A Gene

Enhancers for MYBBP1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004553 1.1 ENCODE 14.4 +0.6 556 2.6 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 LOC101927979 GGT6 MYBBP1A LOC105371492 DHX33 ENSG00000262678 PIR51445
GH17G004533 1.4 Ensembl ENCODE dbSUPER 7.3 +19.6 19582 5.6 ELF3 FOXA2 PKNOX1 NFIB AGO1 THRB GLIS2 CREM EGR2 ZNF263 GGT6 ENSG00000229782 SPNS2 MYBBP1A C17orf107 KIF1C GC17P004547 PIR35626 PIR53941
GH17G004502 1.4 Ensembl ENCODE dbSUPER 5.4 +51.0 50989 4.5 HDGF PKNOX1 FOXA2 ZFP64 BMI1 TCF12 ZNF121 FOS EGR2 ZNF680 LOC101927979 ZNF594 ZNF232 LOC100130950 LOC105371492 INCA1 DHX33 MYBBP1A ENSG00000229782 GC17M004505
GH17G004540 1 ENCODE dbSUPER 7.5 +14.6 14642 1.5 CTCF KLF1 ZSCAN4 ZIC2 RAD21 HIC1 ZBTB48 POLR2A PATZ1 NR2F6 MYBBP1A GC17P004547 PIR35626 PIR53941
GH17G004530 1 ENCODE dbSUPER 6.5 +24.6 24565 2.0 BCOR AGO1 JUN ZMYM3 CEBPG RAD21 ZNF791 GLIS2 ZNF366 POLR2A LOC101927979 GGT6 ENSG00000229782 SPNS2 LOC105371492 MYBBP1A PIR53941 GC17P004547 PIR35626
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYBBP1A on UCSC Golden Path with GeneCards custom track

Promoters for MYBBP1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090492 331 1401 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for MYBBP1A Gene

Chromosome:
17
Start:
4,538,896 bp from pter
End:
4,555,631 bp from pter
Size:
16,736 bases
Orientation:
Minus strand

Genomic View for MYBBP1A Gene

Genes around MYBBP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYBBP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYBBP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBBP1A Gene

Proteins for MYBBP1A Gene

  • Protein details for MYBBP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQG0-MBB1A_HUMAN
    Recommended name:
    Myb-binding protein 1A
    Protein Accession:
    Q9BQG0
    Secondary Accessions:
    • Q86VM3
    • Q9BW49
    • Q9P0V5
    • Q9UF99

    Protein attributes for MYBBP1A Gene

    Size:
    1328 amino acids
    Molecular mass:
    148855 Da
    Quaternary structure:
    • Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
    SequenceCaution:
    • Sequence=CAB66530.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYBBP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBBP1A Gene

Post-translational modifications for MYBBP1A Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys56, Lys161, posLast=179179, posLast=231231, Lys988, posLast=10361036, and posLast=11401140
  • Modification sites at PhosphoSitePlus

Other Protein References for MYBBP1A Gene

No data available for DME Specific Peptides for MYBBP1A Gene

Domains & Families for MYBBP1A Gene

Suggested Antigen Peptide Sequences for MYBBP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYBBP1A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MYBBP1A Gene

Function for MYBBP1A Gene

Molecular function for MYBBP1A Gene

GENATLAS Biochemistry:
MYB binding protein 1A,expressed in pancreas,kidney,brain,colon,prostate,nuclear predominantly localized in the nucleolus
UniProtKB/Swiss-Prot Function:
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 Lys-9 (H3K9me2) on the PER2 promoter.

Gene Ontology (GO) - Molecular Function for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding ISS --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IEA,ISS --
GO:0003723 RNA binding IDA 22658674
GO:0003887 DNA-directed DNA polymerase activity IEA --
genes like me logo Genes that share ontologies with MYBBP1A: view
genes like me logo Genes that share phenotypes with MYBBP1A: view

Animal Models for MYBBP1A Gene

MGI Knock Outs for MYBBP1A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYBBP1A Gene

Localization for MYBBP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBBP1A Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250 UniProtKB:Q7TPV4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYBBP1A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with MYBBP1A: view

Pathways & Interactions for MYBBP1A Gene

genes like me logo Genes that share pathways with MYBBP1A: view

SIGNOR curated interactions for MYBBP1A Gene

Other effect:

Gene Ontology (GO) - Biological Process for MYBBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10644447
GO:0006913 nucleocytoplasmic transport IEA,ISS --
GO:0022904 respiratory electron transport chain IEA --
genes like me logo Genes that share ontologies with MYBBP1A: view

Drugs & Compounds for MYBBP1A Gene

(4) Drugs for MYBBP1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for MYBBP1A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2
genes like me logo Genes that share compounds with MYBBP1A: view

Transcripts for MYBBP1A Gene

Unigene Clusters for MYBBP1A Gene

MYB binding protein (P160) 1a:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYBBP1A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c
SP1:
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for MYBBP1A Gene

GeneLoc Exon Structure for
MYBBP1A
ECgene alternative splicing isoforms for
MYBBP1A

Expression for MYBBP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYBBP1A Gene

Protein differential expression in normal tissues from HIPED for MYBBP1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), Heart (8.3), Tlymphocyte (6.7), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYBBP1A Gene



Protein tissue co-expression partners for MYBBP1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYBBP1A Gene:

MYBBP1A

SOURCE GeneReport for Unigene cluster for MYBBP1A Gene:

Hs.701718

Evidence on tissue expression from TISSUES for MYBBP1A Gene

  • Nervous system(4.5)
  • Eye(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with MYBBP1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBBP1A Gene

Orthologs for MYBBP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYBBP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBBP1A 35 34
  • 96.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYBBP1A 34 35
  • 82.35 (n)
dog
(Canis familiaris)
Mammalia MYBBP1A 34 35
  • 82.09 (n)
mouse
(Mus musculus)
Mammalia Mybbp1a 34 16 35
  • 76.27 (n)
rat
(Rattus norvegicus)
Mammalia Mybbp1a 34
  • 75.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYBBP1A 35
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBBP1A 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYBBP1A 34 35
  • 60.08 (n)
lizard
(Anolis carolinensis)
Reptilia MYBBP1A 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mybbp1a 34
  • 54.03 (n)
Str.18801 34
zebrafish
(Danio rerio)
Actinopterygii MYBBP1A (2 of 2) 35
  • 48 (a)
OneToMany
mybbp1a 35
  • 41 (a)
OneToMany
Dr.25251 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1017 35
  • 26 (a)
OneToOne
Species where no ortholog for MYBBP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBBP1A Gene

ENSEMBL:
Gene Tree for MYBBP1A (if available)
TreeFam:
Gene Tree for MYBBP1A (if available)

Paralogs for MYBBP1A Gene

No data available for Paralogs for MYBBP1A Gene

Variants for MYBBP1A Gene

Sequence variations from dbSNP and Humsavar for MYBBP1A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs758083465 Uncertain significance 4,555,186(+) CTCCT(A/G)CTCAG reference, stop-gained, utr-variant-5-prime
rs1000256995 -- 4,551,715(+) AAAAA(A/G)AAAAA intron-variant
rs1000317236 -- 4,544,235(+) AGACT(A/G)TCAAG intron-variant
rs1000493473 -- 4,555,624(+) GGCCC(A/G)TCTCG upstream-variant-2KB
rs1000797393 -- 4,553,814(+) CCTCG(A/G)AGAGG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MYBBP1A Gene

Variant ID Type Subtype PubMed ID
esv2715555 CNV deletion 23290073
esv3639785 CNV gain 21293372
esv3639787 CNV gain 21293372
nsv1061858 CNV gain 25217958
nsv574269 CNV gain 21841781
nsv574272 CNV loss 21841781
nsv952109 CNV deletion 24416366

Variation tolerance for MYBBP1A Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.69; 93.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYBBP1A Gene

Human Gene Mutation Database (HGMD)
MYBBP1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYBBP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBBP1A Gene

Disorders for MYBBP1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYBBP1A Gene - From: GeneCards

Disorder Aliases PubMed IDs
brain glioma
  • lower grade glioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MYBBP1A

Genetic Association Database (GAD)
MYBBP1A
Human Genome Epidemiology (HuGE) Navigator
MYBBP1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYBBP1A
genes like me logo Genes that share disorders with MYBBP1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYBBP1A Gene

Publications for MYBBP1A Gene

  1. Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. (PMID: 10644447) Keough R. … Gonda T.J. (Genomics 1999) 2 3 4 22 64
  2. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase. (PMID: 20177074) Perrera C. … Rusconi L. (J. Biol. Chem. 2010) 3 22 64
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 46 64
  4. MYBBP1a is a novel repressor of NF-kappaB. (PMID: 17196614) Owen H.R. … Hottiger M.O. (J. Mol. Biol. 2007) 3 22 64
  5. The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. (PMID: 16603771) Cavellan E. … Oestlund Farrants A.-K. (J. Biol. Chem. 2006) 3 4 64

Products for MYBBP1A Gene

Sources for MYBBP1A Gene

Content
Loading form....