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Aliases for MYB Gene

Aliases for MYB Gene

  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Myb 3 4
  • C-Myb Protein (140 AA) 3
  • C-Myb10A_CDS 3
  • C-Myb13A_CDS 3
  • C-Myb14A_CDS 3
  • C-Myb8B_CDS 3
  • C-Myb_CDS 3
  • C-Myb 3
  • Cmyb 3
  • Efg 3

External Ids for MYB Gene

Previous GeneCards Identifiers for MYB Gene

  • GC06P135349
  • GC06P135483
  • GC06P135544
  • GC06P133066
  • GC06P135503

Summaries for MYB Gene

Entrez Gene Summary for MYB Gene

  • This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for MYB Gene

MYB (V-Myb Avian Myeloblastosis Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with MYB include acute basophilic leukemia and tuberculous salpingitis. Among its related pathways are PI3K-Akt signaling pathway and Neural Crest Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for MYB Gene

  • Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Gene Wiki entry for MYB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYB Gene

Genomics for MYB Gene

Regulatory Elements for MYB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYB Gene

Chromosome:
6
Start:
135,180,981 bp from pter
End:
135,219,173 bp from pter
Size:
38,193 bases
Orientation:
Plus strand

Genomic View for MYB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYB Gene

Proteins for MYB Gene

  • Protein details for MYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10242-MYB_HUMAN
    Recommended name:
    Transcriptional activator Myb
    Protein Accession:
    P10242
    Secondary Accessions:
    • E9PI07
    • E9PLZ5
    • E9PNA4
    • E9PNL6
    • E9PRS2
    • P78391
    • P78392
    • P78525
    • P78526
    • Q14023
    • Q14024
    • Q708E4
    • Q708E7
    • Q9UE83

    Protein attributes for MYB Gene

    Size:
    640 amino acids
    Molecular mass:
    72341 Da
    Quaternary structure:
    • Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.

    Alternative splice isoforms for MYB Gene

neXtProt entry for MYB Gene

Proteomics data for MYB Gene at MOPED

Post-translational modifications for MYB Gene

  • Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
  • Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 53, Lys 204, Lys 293, Lys 442, Lys 445, Lys 471, and Lys 480
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYB (Myb)

No data available for DME Specific Peptides for MYB Gene

Domains & Families for MYB Gene

Gene Families for MYB Gene

Graphical View of Domain Structure for InterPro Entry

P10242

UniProtKB/Swiss-Prot:

MYB_HUMAN :
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Domain:
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
  • Contains 3 HTH myb-type DNA-binding domains.
genes like me logo Genes that share domains with MYB: view

Function for MYB Gene

Molecular function for MYB Gene

GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis
UniProtKB/Swiss-Prot Function:
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
UniProtKB/Swiss-Prot Induction:
Negatively regulated by microRNA-155 (miR-155).

Gene Ontology (GO) - Molecular Function for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7987850
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0005515 protein binding IPI 18093978
genes like me logo Genes that share ontologies with MYB: view
genes like me logo Genes that share phenotypes with MYB: view

Animal Models for MYB Gene

MGI Knock Outs for MYB:

Transcription Factor Targets for MYB Gene

Selected GeneGlobe predicted Target genes for MYB
Targeted motifs for MYB Gene
HOMER Transcription Factor Regulatory Elements motif MYB
  • Consensus sequence: GGCVGTTR Submotif: canonical Cell Type: ERMYB GEO ID: GSE22095

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for MYB Gene

Localization for MYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYB Gene COMPARTMENTS Subcellular localization image for MYB gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005829 cytosol IEA --
GO:0016363 nuclear matrix NAS 3014652
genes like me logo Genes that share ontologies with MYB: view

Pathways & Interactions for MYB Gene

genes like me logo Genes that share pathways with MYB: view

Pathways by source for MYB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
    • Nitric Oxide Signaling Pathway in human,mouse,rat

SIGNOR curated interactions for MYB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0001701 in utero embryonic development IEA --
GO:0006338 chromatin remodeling IMP 20484083
GO:0006355 regulation of transcription, DNA-templated NAS 2189102
genes like me logo Genes that share ontologies with MYB: view

Drugs & Compounds for MYB Gene

(31) Drugs for MYB Gene - From: NovoSeek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Dexamethasone Approved, Investigational Pharma Agonist 1806
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Estradiol Approved, Investigational Pharma Sex hormone 1057
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 567

(28) Additional Compounds for MYB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
4-Hydroxynonenal
  • 4-Hydroxy-2,3-nonenal
  • 4-Hydroxy-2-Nonenal
  • 4-Hydroxynon-2-enal
  • 4-Hydroxynonenal
  • trans-4-Hydroxy-2-nonenal
75899-68-2
Abscisic acid
  • 5-(1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-2,4-pentadienoic acid, 9CI
  • Abscisin II
  • Dormin
7773-56-0
acivicin
Actinomycin D
genes like me logo Genes that share compounds with MYB: view

Transcripts for MYB Gene

Unigene Clusters for MYB Gene

V-myb myeloblastosis viral oncogene homolog (avian):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

Relevant External Links for MYB Gene

GeneLoc Exon Structure for
MYB
ECgene alternative splicing isoforms for
MYB

Expression for MYB Gene

mRNA expression in normal human tissues for MYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYB Gene

This gene is overexpressed in Colon - Transverse (x11.5) and Breast - Mammary Tissue (x5.5).

Protein differential expression in normal tissues from HIPED for MYB Gene

This gene is overexpressed in Monocytes (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYB Gene



SOURCE GeneReport for Unigene cluster for MYB Gene Hs.606320

genes like me logo Genes that share expression patterns with MYB: view

Protein tissue co-expression partners for MYB Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYB Gene

Orthologs for MYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYB 35
  • 92.47 (n)
  • 92.83 (a)
MYB 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYB 35
  • 92.73 (n)
  • 92.9 (a)
C-MYB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myb 35
  • 86.83 (n)
  • 88.59 (a)
Myb 16
Myb 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYB 35
  • 99.12 (n)
  • 98.95 (a)
MYB 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYB 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYB 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYB 35
  • 79.84 (n)
  • 82.66 (a)
C-MYB 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYB 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myb 35
  • 68.86 (n)
  • 67.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398039 35
zebrafish
(Danio rerio)
Actinopterygii cmyb 35
  • 63.07 (n)
  • 63.36 (a)
cmyb 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 37
  • 62 (a)
Myb 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 16 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.38177 35
Species with no ortholog for MYB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYB Gene

ENSEMBL:
Gene Tree for MYB (if available)
TreeFam:
Gene Tree for MYB (if available)

Paralogs for MYB Gene

Paralogs for MYB Gene

genes like me logo Genes that share paralogs with MYB: view

Variants for MYB Gene

Sequence variations from dbSNP and Humsavar for MYB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs210792 -- 135,185,384(+) ATAAT(C/T)CTGTT intron-variant
rs210793 -- 135,185,553(+) TTCTT(C/G)TTCCT intron-variant
rs210794 -- 135,185,622(+) AATGT(A/G)TAACT intron-variant
rs210795 -- 135,188,521(-) AAAAA(A/C)AAAAA intron-variant
rs210796 -- 135,189,970(-) GCCCA(A/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYB Gene

Variant ID Type Subtype PubMed ID
nsv886685 CNV Loss 21882294
nsv5490 CNV Insertion 18451855

Variation tolerance for MYB Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYB Gene

HapMap Linkage Disequilibrium report
MYB
Human Gene Mutation Database (HGMD)
MYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYB Gene

Disorders for MYB Gene

MalaCards: The human disease database

(8) MalaCards diseases for MYB Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
acute basophilic leukemia
tuberculous salpingitis
malignant histiocytosis
  • histiocytic medullary reticulosis [obs]
precursor t-cell acute lymphoblastic leukemia
  • t-all
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
- elite association
Search MYB in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYB

Genetic Association Database (GAD)
MYB
Human Genome Epidemiology (HuGE) Navigator
MYB
Tumor Gene Database (TGDB):
MYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYB
genes like me logo Genes that share disorders with MYB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYB Gene

Publications for MYB Gene

  1. Transcriptional regulatory network triggered by oxidative signals configures the early response mechanisms of japonica rice to chilling stress. (PMID: 20100339) Yun K.Y. … de Los Reyes B.G. (BMC Plant Biol. 2010) 23 67
  2. Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2. (PMID: 20237898) Wilkins H.R. … Johnson N. (Tumour Biol. 2010) 23 67
  3. Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. (PMID: 19056847) Fang F. … Clevenger C.V. (Am. J. Pathol. 2009) 23 67
  4. [Experimental identification of drugs with function of targeted up-regulating ID4 expression: bioinformatics-based prediction and preliminary validation]. (PMID: 19957534) Yang B. … Yu L. (Zhonghua Yi Xue Za Zhi 2009) 23 67
  5. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. (PMID: 19036881) Fang F. … Clevenger C.V. (Endocrinology 2009) 23 67

Products for MYB Gene

Sources for MYB Gene

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