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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYB Gene

protein-coding GIFtS: 69
GCID: GC06P135503

v-myb myeloblastosis viral oncogene homolog (avian)

(Previous name: v-myb avian myeloblastosis viral oncogene homolog )

Explore 80 diseases affiliated with
MYB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)¹ ²		C-Myb13A_CDS¹
C-Myb¹		C-Myb14A_CDS¹
Proto-Oncogene C-Myb² ³		C-Myb8B_CDS¹
V-Myb Avian Myeloblastosis Viral Oncogene Homolog¹		C-Myb_CDS¹
Cmyb²		Efg¹
C-Myb Protein (140 AA)²		Transcriptional Activator Myb²
C-Myb10A_CDS¹

External Ids:	HGNC: 7545¹	Entrez Gene: 4602²	Ensembl: ENSG00000118513⁷	OMIM: 189990⁵	UniProtKB: P10242³

Export aliases for MYB gene to outside databases

Previous GC identifers: GC06P135125 GC06P135349 GC06P135483 GC06P135544 GC06P133066

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYB:

This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein

contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal

domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis

and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. (provided by

RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'.

Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Gene Wiki entry for MYB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYB gene promoter:
AP-1 Sp1 Pax-6 Bach2 Meis-1b GATA-1 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYB promoter sequence

Search SABiosciences Chromatin IP Primers for MYB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22-q23 Ensembl cytogenetic band: 6q23.3 HGNC cytogenetic band: 6q22-q23

MYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYB gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P135503: view genomic region (about GC identifiers)

Start:	135,502,453 bp from pter	End:	135,540,311 bp from pter
Size:	37,859 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242 (See protein sequence)

Recommended Name: Transcriptional activator Myb

Size: 640 amino acids; 72341 Da

Subunit: Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1

Subcellular location: Nucleus

Secondary accessions: E9PNL6 P78391 P78392 P78525 P78526 Q14023 Q14024 Q708E4 Q708E7 Q9UE83

Alternative splicing: 7 isoforms: P10242-1 P10242-2 P10242-3 P10242-4 P10242-5 P10242-6 P10242-7 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MYB: NX_P10242

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable)¹

Phosphorylated by NLK on multiple sites, which induces proteasomal degradation (By similarity)¹

Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10242

MYB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001123644.1 NP_001123645.1 NP_001155128.1 NP_001155129.1 NP_001155130.1 NP_001155131.1 NP_001155132.1 NP_005366.2

ENSEMBL proteins:

ENSP00000339992 ENSP00000356786 ENSP00000436602 ENSP00000437081 ENSP00000434639

ENSP00000341050 ENSP00000410825 ENSP00000356788 ENSP00000433227 ENSP00000403387

ENSP00000435938 ENSP00000432877 ENSP00000434723 ENSP00000432851 ENSP00000432948

ENSP00000435497 ENSP00000435055 ENSP00000436605 ENSP00000433844 ENSP00000434816

ENSP00000434795 ENSP00000432811 ENSP00000436925 ENSP00000432168 ENSP00000433745

ENSP00000434675 ENSP00000436385 ENSP00000434420 ENSP00000413011 ENSP00000435578

ENSP00000435595 ENSP00000434917 ENSP00000433458 ENSP00000435293 ENSP00000437264

ENSP00000390460 ENSP00000432042 ENSP00000326328

Reactome Protein details: P10242
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MYB OriGene Custom Protein Services for MYB
	GenScript Custom Purified and Recombinant Proteins Services for MYB
	Novus Biologicals MYB Proteins Novus Biologicals MYB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MYB

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0016363	nuclear matrix	NAS	3014652

MYB for ontologies About GeneDecksing

MYB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MYB
	R&D Systems Antibodies for MYB
	Cell Signaling Technology (CST) Antibodies for MYB
	OriGene Antibodies (see all 3): MYB OriGene Custom Antibody Services for MYB
	GenScript Superior Antibodies for MYB
	Novus Biologicals MYB Antibodies
	Abcam antibodies for MYB
	Uscn Antibodies for MYB
	ThermoFisher Antibody for MYB

Assay Products for MYB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MYB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYB for domains About GeneDecksing

5 InterPro domains/families:

IPR001005 SANT/Myb

IPR009057 Homeodomain-like

IPR012642 Tscrpt_reg_Wos2-domain

IPR015395 C-myb_C

IPR017930 Myb_dom

Graphical View of Domain Structure for InterPro Entry P10242

ProtoNet protein and cluster: P10242

2 Blocks protein families:

IPB001005 Myb DNA-binding domain

IPB012642 Mitotic Wos2

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Domain: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain

and a C-terminal domain involved in transcriptional repression

Similarity: Contains 3 HTH myb-type DNA-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'.

Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Genatlas biochemistry entry for MYB:

avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis

miRNA Products:		miRTarBase miRNAs that target MYB: hsa-mir-424 (MIRT005886), hsa-mir-34c-5p (MIRT000746), hsa-mir-16 (MIRT004637), rno-mir-150 (MIRT003539), hsa-mir-34b (MIRT000747), hsa-mir-155 (MIRT005884), hsa-mir-34a (MIRT000720), hsa-mir-107 (MIRT003802), hsa-mir-150 (MIRT000935), hsa-mir-15a (MIRT000283)

		OriGene 3'-UTR Clone (see all 8): MYB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYB
		8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate MYB (see all 51):
		hsa-miR-21* hsa-miR-579 hsa-miR-429 hsa-miR-15a hsa-miR-3616-5p hsa-miR-503 hsa-miR-301a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: MYB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYB (see all 4) OriGene shRNA RFP: MYB OriGene siRNA: MYB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYB (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYB (see all 8) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): MYB (NM_001130172)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYB
		Search LifeMap BioReagents cell lines for MYB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	--

MYB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MYB:

Decreased viability

Animal Models:
Mouse knock-outs for MYB: Myb^tm1Ssp Myb^tm1.1Cgn
11 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Myb):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
immune system	integument	liver/biliary system	mortality/aging	no phenotypic analysis
normal

MYB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Proteolysis Putative SUMO-1 pathway

Proteolysis Putative SUMO-1 pathway

1.00

Proteolysis_Putative SUMO-1 pathway

0.97

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MYB

Proteolysis Putative SUMO-1 pathway

1 Cell Signaling Technology (CST) Pathway for MYB

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for MYB

Proteolysis Putative SUMO-1 pathway

5/7 BioSystems Pathways for MYB (see all 7)

	Neural Crest Differentiation
	SIDS Susceptibility Pathways
	Wnt Signaling Pathway NetPath
	IL2 signaling events mediated by PI3K
	C-MYB transcription factor network

2 Reactome Pathways for MYB

	Hemostasis
	Factors involved in megakaryocyte development and platelet production

MYB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MYB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/133 Interacting proteins for MYB (P10242^{1, 2, 3} ENSP00000339992⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LIN9	Q5TKA1²^,³, ENSP00000329102⁴	MINT-6802201 I2D: score=1 STRING: ENSP00000329102
ERC2	O15083¹^,³	EBI-298355,EBI-2684336 I2D: score=1
ZFC3H1	O60293¹^,³	EBI-298355,EBI-2874127 I2D: score=1
CLTC	Q00610²^,³, ENSP00000269122⁴	MINT-6802049 MINT-6802128 MINT-6802167 MINT-6802072 I2D: score=1 STRING: ENSP00000269122
FLNA	P21333², ENSP00000358866⁴	MINT-6802049 MINT-6802167 MINT-6802072 STRING: ENSP00000358866

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	--
GO:0001701	in utero embryonic development	IEA	--
GO:0006338	chromatin remodeling	IMP	--
GO:0006351	transcription, DNA-dependent	IEA	--

MYB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYB
10/58 Novoseek chemical compound relationships for MYB gene (see all 58) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	39.5	14	15563404 (2), 1544939 (1), 1594446 (1), 8058310 (1) (see all 10)
dbds	39.1	1	11522824 (1)
chloramphenicol	34.7	13	7929419 (1), 1527086 (1), 7706314 (1), 7721862 (1) (see all 9)
acivicin	32	4	1596574 (2), 1997162 (1)
leucine	31.4	19	8195231 (2), 1306303 (2), 2189102 (1), 15019774 (1) (see all 7)
methylcellulose	29.7	3	8630382 (1), 8643572 (1)
aclarubicin	26.6	11	1640736 (5), 7845009 (5)
phosphorothioate	25.6	1	15001837 (1)
dmso	25.4	15	2406276 (2), 1533276 (2), 8496152 (2), 1323820 (2) (see all 9)
retinoic acid	24.3	14	11290610 (5), 7739532 (1), 9576918 (1), 2088479 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about MYB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYB gene (8 alternative transcripts):

NM_001130172.1 NM_001130173.1 NM_001161656.1 NM_001161657.1 NM_001161658.1 NM_001161659.1 NM_001161660.1 NM_005375.2

Unigene Cluster for MYB:

V-myb myeloblastosis viral oncogene homolog (avian)

Hs.606320 [show with all ESTs]

Unigene Representative Sequence: NM_001130173

18/40 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 40):

ENST00000341911(uc003qfh.3 uc003qfz.3 uc003qfi.3 uc003qfm.3 uc003qfp.3 uc003qfq.3 uc003qfy.3)

ENST00000367812 ENST00000463282(uc003qfr.3) ENST00000525477(uc003qfx.3 uc003qfg.3 uc003qfk.3 uc003qft.3 uc003qfs.3)

ENST00000533837(uc003qfv.3 uc003qfd.3 uc003qff.3) ENST00000339290(uc003qfb.1 uc003qfl.3 uc003qga.3 uc003qfj.3 uc003qfn.3)

ENST00000442647(uc010kgj.3 uc003qfu.3) ENST00000367814 ENST00000527615

ENST00000420123 ENST00000525369 ENST00000528140 ENST00000528774 ENST00000534121

ENST00000525940 ENST00000528345 ENST00000534044 ENST00000533624

miRNA Products:		OriGene 3'-UTR Clone (see all 8): MYB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYB
		8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate MYB (see all 51):
		hsa-miR-21* hsa-miR-579 hsa-miR-429 hsa-miR-15a hsa-miR-3616-5p hsa-miR-503 hsa-miR-301a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: MYB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYB (see all 4) OriGene shRNA RFP: MYB OriGene siRNA: MYB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYB (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYB (see all 8) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): MYB (NM_001130172)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MYB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYB

Additional cDNA sequence:

AF104863.1 AJ606319.1 AJ606320.1 AJ616235.1 AJ616791.1 AJ616792.1 AJ616795.1 AJ616796.4

AJ616798.1 AJ616800.1 AJ616801.1 AJ616802.1 AJ616803.1 AJ616804.1 AJ616805.1 AY787443.1

AY787444.1 AY787445.1 AY787446.1 AY787447.1 AY787448.1 AY787449.1 AY787451.1 AY787452.1

AY787455.1 AY787456.1 AY787457.1 AY787458.1 AY787460.1 AY787461.1 AY787462.1 AY787463.1

AY787465.1 AY787466.1 AY787467.1 AY787468.1 AY787469.1 AY787470.1 AY787471.1 AY787472.1

AY787473.1 AY787474.1 AY787475.1 BC035996.1 BC064955.1 FJ969915.1 FJ969916.1 FJ969917.1

M13665.1 M13666.1 M15024.1 X17469.1 X52125.1

23 DOTS entries:

DT.121338061 DT.102831632 DT.99927129 DT.102831631 DT.102831629 DT.121338068 DT.102831626 DT.121338051

DT.121338057 DT.102831630 DT.121338040 DT.445839 DT.100773244 DT.98131948 DT.121338049 DT.121338062

DT.121338063 DT.121338070 DT.121338076 DT.95160870 DT.121184205 DT.91768086 DT.91900755

24/109 AceView cDNA sequences (see all 109):

AJ616800 BE870267 AJ616802 AJ616797 BQ212680 AJ616798 AJ606323 AJ606319

AJ606317 M13665 AJ606321 AJ616791 BX107408 AJ616803 AJ616793 M13666

AJ606324 X52126 CB163433 AJ616799 AJ616805 AJ616796 AI365339 BQ220472

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYB (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:					-		-																		-		-						-		-				-										-
SP2:					-		-																				-						-		-				-										-
SP3:					-		-																				-		-						-				-										-
SP4:					-		-																				-		-				-						-										-
SP5:					-		-																				-		-				-		-														-

ECgene alternative splicing isoforms for MYB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCTGTGT

About this image

MYB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

Common Lymphoid Progenitor Cells

Selective marker (cell-identifying gene)

Blood

Peripheral Blood

Common Myeloid Progenitor Cells

Blood

Lateral Plate Mesoderm

Aorta-Gonad-Mesonephros

Hematopoietic Stem Cells

Blood

Liver

Liver Bud

Hematopoietic Stem Cells

Blood

Blood

Hematopoietic Stem Cells

Blood

Kidney

Ureteric Bud

Ureteric Bud Tip Cells

Kidney

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYB

SOURCE GeneReport for Unigene cluster: Hs.606320

SABiosciences Expression via Pathway-Focused PCR Arrays including MYB:

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Transcription Factors in human mouse rat

T Helper Cell Differentiation in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYB gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYB¹	v-myb myeloblastosis viral oncogene homolog (avian)	79.84(n) 82.66(a)		396244 NM_205306.1 NP_990637.1
lizard (Anolis carolinensis)	Reptilia	MYB⁶	--	75(a)	1 ↔ 1	GL343200.1(3091335-3126684)
African clawed frog (Xenopus laevis)	Amphibia	LOC398039²	DNA-binding transcriptional regulator	75.55(n)		L22741.1
zebrafish (Danio rerio)	Actinopterygii	cmyb²	transcription factor cmyb	75.8(n)		30519 AF191559.1
fruit fly (Drosophila melanogaster)	Insecta	Myb³	cell cycle DNA binding	62(a)		13F14 --
worm (Caenorhabditis elegans)	Secernentea	gei-11⁶	GEX Interacting protein family member (gei-11)	6(a)	possible ortholog	I(8962315-8966123)
thale cress (Arabidopsis thaliana)	eudicotyledons	MYB100⁶ MYB3R-3⁶ (see all 12)	myb domain protein 3r-3 (see all 12)	24(a) 23(a) (see all 12)	possible ortholog many ↔ many (see all 12)	2(10747211-10748467) 3(2879366-2882267)
rice (Oryza sativa)	Liliopsida	Os.38177²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	76.5(n)		AK066520.1

ENSEMBL Gene Tree for MYB (if available)
TreeFam Gene Tree for MYB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYB gene

MYBL2² MYBL1² SNAPC4²

18/22 SIMAP similar genes for MYB using alignment to 26 protein entries: MYB_HUMAN (see all proteins) (see all similar genes):

c-myb MYB/NFIB fusion AURA2 C4orf22 NF2 RBP7

HMGA2 AGBL3 CASP7 FAM175A FP6651 KIAA1651

DNAPTP3 GLT8D2 ENSA TIGD1L2 EIF3L OK/SW-cl.41

MYB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145469477^1,2		--	135500536(+)	`AAAATC/GATTTA`	8	--	us2k¹		0	--	--	--	--
rs5880249^1,2	C,	--	135500543(+)	`CAAAG-/AAAAAA`	8	--	us2k¹ trp³		1		CSA	2
rs5880250^1,2	C	--	135500547(+)	`AAAAA-/AGGAAA`	8	--	us2k¹ trp³		0	--	--	--	--
rs201493795^1,2		--	135500550(+)	`GAAAA-/GAAAGG`	8	--	us2k¹		0	--	--	--	--
rs75992340^1,2	C,F,	--	135500583(+)	`TACTTT/CAAAGG`	8	--	us2k¹		2		NS WA	486
rs7454405^1,2	C	--	135500620(+)	`CACCTC/GCTAAA`	8	--	us2k¹		0	--	--	--	--
rs113229859^1,2	C,F,	--	135500736(+)	`AATCCG/AAAAGC`	8	--	us2k¹		1		NS	368
rs113466874^1,2	C,	--	135500740(+)	`CGAAAG/TCCAGA`	8	--	us2k¹		2		CSA NS	370
rs6938173^1,2	C,F,	--	135500773(+)	`TTCTAG/CATGTT`	8	--	us2k¹		6		NA WA NS EA	730
rs9494170^1,2	C,F,	--	135500929(+)	`TGTTTC/GAGTGT`	8	--	us2k¹		2		NS WA	408

HapMap Linkage Disequilibrium report for MYB (135502453 - 135540311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYB: --
Human Gene Mutation Database (HGMD): MYB

Locus Specific Mutation Databases (LSDB): MYB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYB for disorders           About GeneDecksing

OMIM gene information: 189990    OMIM disorders: --

20/80 diseases for MYB (see all 80):    About MalaCards

polymorphous low-grade adenocarcinoma estrogen-receptor positive breast cancer supratentorial primitive neuroectodermal tumor human t-cell leukemia virus type 1

hematopoiesis primitive neuroectodermal tumor neuroectodermal tumors malignant histiocytosis

non-hodgkin lymphoma myeloid leukemia lymphosarcoma acute lymphoblastic leukemia

myelomonocytic leukemia lymphoblastic leukemia primary effusion lymphoma burkitt's lymphoma

histiocytosis b-cell lymphomas acute myelomonocytic leukemia viral hepatitis

10/65 Novoseek disease relationships for MYB gene (see all 65) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloblastosis	73.3	4	12490953 (1), 11080802 (1), 18930885 (1), 8336948 (1)
lymphosarcoma bovine	70.2	2	8116930 (1), 7929419 (1)
myeloid leukemia	68.3	13	12631292 (1), 2088479 (1), 8654374 (1), 11956664 (1) (see all 11)
leukemogenesis	61	9	9271390 (1), 15540222 (1), 12384144 (1), 18505338 (1) (see all 6)
leukemia	60.7	67	18195038 (3), 19427836 (3), 1588953 (3), 1560675 (2) (see all 34)
erythroleukemia	54.1	9	8132611 (2), 8496152 (2), 1533276 (1), 1640736 (1) (see all 6)
hematopoietic malignancies	48.4	2	10880029 (1), 9258605 (1)
blast crisis	45.1	9	16797705 (3), 8967957 (2), 9737692 (1), 18550858 (1)
malignant histiocytosis	41.1	1	8352523 (1)
t-all	40.6	6	18070937 (2), 15044598 (1), 17435759 (1), 15921375 (1)

Genetic Association Database (GAD): MYB
Human Genome Epidemiology (HuGE) Navigator: MYB (22 documents)
Tumor Gene Database (TGDB): MYB

Export disorders for MYB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYB gene, integrated from 9 sources (see all 581):
(articles sorted by number of sources associating them with MYB)

Utopia: connect your pdf to the dynamic
world of online information

Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. (PubMed id 1944282)^{1, 2, 9} Nicolaides N.C.... Calabretta B. (1991)
The intron 6 G/T polymorphism of c-myb oncogene and the risk for coronary in-stent restenosis. (PubMed id 15221349)^{1, 4, 9} Gross C.M....Praus M. (2004)
Alternative splicing of the human c-myb gene. (PubMed id 2202948)^{1, 2, 9} Westin E.H.... Clarke M.F. (1990)
Transcriptional activation by human c-myb and v-myb genes. (PubMed id 2189102)^{1, 2, 9} Kalkbrenner F.... Moelling K. (1990)
HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. (PubMed id 19646965)^{1, 2} Matre V....Gabrielsen O.S. (2009)
The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. (PubMed id 17599807)^{1, 3} Chen Y....Mo X. (2007)
Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults. (PubMed id 15169551)^{1, 2} Close J.P....Thein S.L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. (PubMed id 10747903)^{1, 2} Tanikawa J.... Ishii S. (2000)
Identification of a second promoter in the human c-myb proto- oncogene. (PubMed id 8302584)^{1, 2} Jacobs S.M.... Westin E.H. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4602	HGNC: 7545	AceView: MYB	Ensembl:ENSG00000118513	euGenes: HUgn4602
ECgene: MYB	H-InvDB: MYB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MYB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MYB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYB gene:
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GeneCards and IP:
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v-myb myeloblastosis viral oncogene homolog (avian)

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MYB Gene

v-myb myeloblastosis viral oncogene homolog (avian)

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