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Aliases for MYB Gene

Aliases for MYB Gene

  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Myb 3 4
  • Transcriptional Activator Myb 3
  • C-Myb Protein (140 AA) 3
  • C-Myb10A_CDS 3
  • C-Myb13A_CDS 3
  • C-Myb14A_CDS 3
  • C-Myb8B_CDS 3
  • C-Myb_CDS 3
  • C-Myb 3
  • Cmyb 3
  • Efg 3

External Ids for MYB Gene

Previous GeneCards Identifiers for MYB Gene

  • GC06P135349
  • GC06P135483
  • GC06P135544
  • GC06P133066
  • GC06P135503

Summaries for MYB Gene

Entrez Gene Summary for MYB Gene

  • This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for MYB Gene

MYB (V-Myb Avian Myeloblastosis Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with MYB include acute basophilic leukemia and malignant histiocytosis. Among its related pathways are PI3K-Akt signaling pathway and Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for MYB Gene

  • Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Gene Wiki entry for MYB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYB Gene

Genomics for MYB Gene

Regulatory Elements for MYB Gene

Genomic Location for MYB Gene

Start:
135,181,315 bp from pter
End:
135,219,173 bp from pter
Size:
37,859 bases
Orientation:
Plus strand

Genomic View for MYB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYB Gene

Proteins for MYB Gene

  • Protein details for MYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10242-MYB_HUMAN
    Recommended name:
    Transcriptional activator Myb
    Protein Accession:
    P10242
    Secondary Accessions:
    • E9PI07
    • E9PLZ5
    • E9PNA4
    • E9PNL6
    • E9PRS2
    • P78391
    • P78392
    • P78525
    • P78526
    • Q14023
    • Q14024
    • Q708E4
    • Q708E7
    • Q9UE83

    Protein attributes for MYB Gene

    Size:
    640 amino acids
    Molecular mass:
    72341 Da
    Quaternary structure:
    • Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.

    Alternative splice isoforms for MYB Gene

neXtProt entry for MYB Gene

Proteomics data for MYB Gene at MOPED

Post-translational modifications for MYB Gene

  • Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
  • Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys53, Lys84, Lys97, Lys109, Lys171, Lys204, Lys293, Lys442, Lys445, Lys471, and Lys480
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYB Gene

Domains for MYB Gene

Graphical View of Domain Structure for InterPro Entry

P10242

UniProtKB/Swiss-Prot:

MYB_HUMAN :
  • P10242
Domain:
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
  • Contains 3 HTH myb-type DNA-binding domains.
genes like me logo Genes that share domains with MYB: view

No data available for Gene Families for MYB Gene

Function for MYB Gene

Molecular function for MYB Gene

GENATLAS Biochemistry: avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis
UniProtKB/Swiss-Prot Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
UniProtKB/Swiss-Prot Induction: Negatively regulated by microRNA-155 (miR-155).

Gene Ontology (GO) - Molecular Function for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7987850
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with MYB: view
genes like me logo Genes that share phenotypes with MYB: view

Animal Models for MYB Gene

MGI Knock Outs for MYB:

Transcription Factor Targeting for MYB Gene

Selected GeneGlobe predicted Target genes for MYB
Targeting motifs for MYB Gene
HOMER Transcription Factor Regulatory Elements motif MYB
  • Consensus sequence: GGCVGTTR Submotif: canonical Cell Type: ERMYB GeoId: GSE22095

No data available for Enzyme Numbers (IUBMB) for MYB Gene

Localization for MYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYB Gene COMPARTMENTS Subcellular localization image for MYB gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005829 cytosol IEA --
GO:0016363 nuclear matrix NAS 3014652
genes like me logo Genes that share ontologies with MYB: view

Pathways for MYB Gene

genes like me logo Genes that share pathways with MYB: view

Pathways by source for MYB Gene

Gene Ontology (GO) - Biological Process for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0001701 in utero embryonic development IEA --
GO:0006338 chromatin remodeling IMP 20484083
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MYB: view

Compounds for MYB Gene

(58) Novoseek inferred chemical compound relationships for MYB Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 39.5 11
dbds 39.1 1
chloramphenicol 34.7 9
acivicin 32 3
leucine 31.4 9
genes like me logo Genes that share compounds with MYB: view

Transcripts for MYB Gene

Unigene Clusters for MYB Gene

V-myb myeloblastosis viral oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

Relevant External Links for MYB Gene

GeneLoc Exon Structure for
MYB
ECgene alternative splicing isoforms for
MYB

Expression for MYB Gene

mRNA expression in normal human tissues for MYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYB Gene

This gene is overexpressed in Colon - Transverse (11.5) and Breast - Mammary Tissue (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYB Gene

SOURCE GeneReport for Unigene cluster for MYB Gene Hs.606320

genes like me logo Genes that share expressions with MYB: view

No data available for mRNA Expression by UniProt/SwissProt for MYB Gene

Orthologs for MYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYB 35
  • 99.12 (n)
  • 98.95 (a)
MYB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYB 35
  • 92.47 (n)
  • 92.83 (a)
MYB 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C-MYB 36
  • 93 (a)
OneToOne
MYB 35
  • 92.73 (n)
  • 92.9 (a)
mouse
(Mus musculus)
Mammalia Myb 35
  • 86.83 (n)
  • 88.59 (a)
Myb 16
Myb 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYB 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYB 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves C-MYB 36
  • 83 (a)
OneToOne
MYB 35
  • 79.84 (n)
  • 82.66 (a)
lizard
(Anolis carolinensis)
Reptilia MYB 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398039 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myb 35
  • 68.86 (n)
  • 67.2 (a)
zebrafish
(Danio rerio)
Actinopterygii cmyb 35
  • 63.07 (n)
  • 63.36 (a)
cmyb 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 36
  • 32 (a)
OneToMany
Myb 37
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 16 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.38177 35
Species with no ortholog for MYB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYB Gene

ENSEMBL:
Gene Tree for MYB (if available)
TreeFam:
Gene Tree for MYB (if available)

Paralogs for MYB Gene

Paralogs for MYB Gene

genes like me logo Genes that share paralogs with MYB: view

Variants for MYB Gene

Sequence variations from dbSNP and Humsavar for MYB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs210792 -- 135,185,384(+) ATAAT(C/T)CTGTT intron-variant
rs210793 -- 135,185,553(+) TTCTT(C/G)TTCCT intron-variant
rs210794 -- 135,185,622(+) AATGT(A/G)TAACT intron-variant
rs210795 -- 135,188,521(-) AAAAA(A/C)AAAAA intron-variant
rs210796 -- 135,189,970(-) GCCCA(A/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYB Gene

Variant ID Type Subtype PubMed ID
nsv886685 CNV Loss 21882294
nsv5490 CNV Insertion 18451855

Relevant External Links for MYB Gene

HapMap Linkage Disequilibrium report
MYB
Human Gene Mutation Database (HGMD)
MYB
Locus Specific Mutation Databases (LSDB)
MYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYB Gene

Disorders for MYB Gene

(2) University of Copenhagen DISEASES for MYB Gene

(65) Novoseek inferred disease relationships for MYB Gene

Disease -log(P) Hits PubMed IDs
myeloblastosis 73.3 4
lymphosarcoma bovine 70.2 2
myeloid leukemia 68.3 11
leukemogenesis 61 6
leukemia 60.7 47

Relevant External Links for MYB

Genetic Association Database (GAD)
MYB
Human Genome Epidemiology (HuGE) Navigator
MYB
Tumor Gene Database (TGDB):
MYB
genes like me logo Genes that share disorders with MYB: view

No data available for UniProtKB/Swiss-Prot for MYB Gene

Publications for MYB Gene

  1. Transcriptional activation by human c-myb and v-myb genes. (PMID: 2189102) Kalkbrenner F. … Moelling K. (Oncogene 1990) 3 4 23
  2. Alternative splicing of the human c-myb gene. (PMID: 2202948) Westin E.H. … Clarke M.F. (Oncogene 1990) 3 4 23
  3. Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. (PMID: 1944282) Nicolaides N.C. … Calabretta B. (Mol. Cell. Biol. 1991) 3 4 23
  4. The intron 6 G/T polymorphism of c-myb oncogene and the risk for coronary in-stent restenosis. (PMID: 15221349) Gross C.M. … Praus M. (Basic Res. Cardiol. 2004) 3 23 48
  5. Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients. (PMID: 19148297) Creary L.E. … Thein S.L. (PLoS ONE 2009) 3 23 48

Products for MYB Gene

  • Addgene plasmids for MYB

Sources for MYB Gene

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