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MYB Gene

protein-coding GIFtS: 68

GC06P135544

v-myb myeloblastosis viral oncogene homolog (avian)
(Previous name: v-myb avian myeloblastosis viral oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-myb ^³
Cmyb ^²
OTTHUMP00000017258 ^²
c-myb ^¹, ²
c-myb10A_CDS ^²
c-myb13A_CDS ^²
c-myb14A_CDS ^²
c-myb8B_CDS ^²
c-myb_CDS ^²
efg ^²

Descriptions
c-myb protein (140 AA) ^²
v-myb avian myeloblastosis viral oncogene homolog ^¹
v-myb myeloblastosis viral oncogene homolog ^²
v-myb myeloblastosis viral oncogene homolog (avian) ^²

External Ids
HGNC: 7545¹
Entrez Gene: 4602²
UniProtKB: P10242³
Ensembl: ENSG00000118513⁷

Search outside databases for aliases for MYB gene

Previous GC identifers: GC06P135125 GC06P135349 GC06P135483

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MYB:

This gene encodes a transcription factor that is a member of the MYB family of transcription factor

genes. The protein contains three domains, an N-terminal DNA-binding domain, a central

transcriptional activation domain and a C-terminal domain involved in transcriptional repression.

This protein plays an essential role in the regulation of hematopoiesis and may play role in

tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence

5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of

hematopoietic progenitor cells

Gene Wiki entry for MYB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYB gene

Entrez Gene cytogenetic band: 6q22-q23 Ensembl cytogenetic band: 6q23.3 HGNC cytogenetic band: 6q22-q23

MYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P135544: (about GC identifiers)

Start:	135,544,146 bp from pter
End:	135,582,003 bp from pter
Size:	37,858 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242 (See protein sequence)

Recommended Name: Myb proto-oncogene protein

Size: 640 amino acids; 72341 Da

Subunit: Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity)

Subcellular location: Nucleus

Secondary accessions: P78391 P78392 P78525 P78526 Q14023 Q14024 Q9UE83

Alternative splicing: 6 isoforms: P10242-1 P10242-2 P10242-3 P10242-4 P10242-5 P10242-6

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable)¹

Phosphorylated by NLK on multiple sites, which induces proteasomal degradation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001123644.1 NP_001123645.1 NP_005366.2

ENSEMBL proteins:

ENSP00000339992 ENSP00000356786 ENSP00000356788 ENSP00000326328 ENSP00000237302 ENSP00000341050

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (v-Myb + c-Myb, c-Myb)
	Human Recombinant Proteins from Abnova (MYB)

OriGene Purified Recombinant Human Protein: MYB

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0016363	nuclear matrix	NAS	3014652

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Antibodies for MYB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MYB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (v-Myb + c-Myb, c-Myb), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MYB)
	Novus Biologicals Antibodies for MYB

Assays for MYB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10242

ProtoNet protein and cluster: P10242

2 Blocks protein families:

IPB001005 Myb DNA-binding domain

IPB012642 Mitotic Wos2

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Domain: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located

transcriptional activation domain and a C-terminal domain involved in transcriptional repression

Similarity: Contains 3 HTH myb-type DNA-binding domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005375

Applied Biosystems Silencer® siRNAs for MYB

Sigma-Aldrich siRNA for MYB

Sigma-Aldrich shRNA Panels and shRNA for MYB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MYB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130172
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130172
untagged cDNA clones in CMV expression vector (see all 3): NM_001130172

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001130173

UniProtKB/Swiss-Prot: MYB_HUMAN, P10242

Function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence

5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of

hematopoietic progenitor cells

Genatlas biochemistry entry for MYB:

avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis

7 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Myb):

growth/size	hematopoietic system	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging
liver/biliary system	normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	15082531 16799563
GO:0016563	transcription activator activity	NAS	2189102

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for MYB

5/114 Interacting proteins for MYB (ENSP00000339992³ P10242^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 114 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIPK2	Q9H2X6¹	STRING (score=.973) EBI-298355, EBI-348345
MED15	Q96RN5¹	STRING (score=.85) EBI-298355, EBI-394506
NLK	Q9UBE8¹	STRING (score=.894) EBI-298355, EBI-366978
LIN9	Q5TKA1²	STRING (score=.717) MINT-6802201
Crebbp Crebbp (xeno)	P45481¹	EBI-298355, EBI-296306

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	2189102

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MYB
10/28 Novoseek chemical compound relationships for MYB gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dbds	40.84	1	11522824 (1)
oligonucleotide	38.44	14	15563404 (2), 1544939 (1), 1594446 (1), 8058310 (1) (see all 10)
leucine	32.60	19	8195231 (2), 1306303 (2), 2189102 (1), 15019774 (1) (see all 7)
phosphorothioate	26.56	1	15001837 (1)
thymidine	20.42	21	1717494 (1), 1944282 (1), 1485708 (1), 1705831 (1) (see all 10)
nitroblue tetrazolium	19.45	1	1511460 (1)
phorbol	11.28	3	1323820 (1), 7651737 (1)
abscisic acid	10.02	4	12509522 (2)
12-o-tetradecanoylphorbol 13-acetate	6.77	6	12354938 (2), 1450490 (1)
steroid	4.47	2	16263717 (1), 9238849 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005375

Sigma-Aldrich siRNA for MYB

Sigma-Aldrich shRNA Panels and shRNA for MYB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130172 NM_001130173 NM_005375

REFSEQ mRNAs for MYB gene (3 alternative transcripts):

NM_001130172.1 NM_001130173.1 NM_005375.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130172 NM_001130173 NM_005375

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130172
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130172
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001130172

Additional cDNA sequence:

AF104863.1 AJ606319.1 AJ606320.1 AJ616235.1 AJ616791.1 AJ616792.1 AJ616795.1 AJ616796.4

AJ616798.1 AJ616800.1 AJ616801.1 AJ616802.1 AJ616803.1 AJ616804.1 AJ616805.1 AY787443.1

AY787444.1 AY787445.1 AY787446.1 AY787447.1 AY787448.1 AY787449.1 AY787451.1 AY787452.1

AY787455.1 AY787456.1 AY787457.1 AY787458.1 AY787460.1 AY787461.1 AY787462.1 AY787463.1

AY787465.1 AY787466.1 AY787467.1 AY787468.1 AY787469.1 AY787470.1 AY787471.1 AY787472.1

AY787473.1 AY787474.1 AY787475.1 BC035996.1 BC064955.1 M13665.1 M13666.1 M15024.1

X17469.1 X52125.1

20 DOTS entries:

DT.121338061 DT.102831632 DT.99927129 DT.102831631 DT.102831629 DT.121338068 DT.102831626 DT.121338051

DT.121338057 DT.102831630 DT.121338040 DT.445839 DT.100773244 DT.98131948 DT.121338049 DT.121338062

DT.121338063 DT.121338070 DT.121338076 DT.95160870

24/109 AceView cDNA sequences (see all 109 ):

BX107408 CB163433 BC064955 BC035996 AJ616800 AJ606322 NM_005375 AA807457

AJ606324 AJ616793 AJ616794 AJ616791 BQ220472 AJ606320 AJ616801 CA310616

BQ212680 BE870267 AJ616797 AJ606321 AJ606319 AJ616802 AJ616798 AJ616792

highest scoring ESTs for MYB:

M15024 AA535078 AA622496 AA678524 AA807457 AF104863 AI085897 AI630041 AI708084 AI923729

Unigene Cluster for MYB:

V-myb myeloblastosis viral oncogene homolog (avian)

Hs.654446 [show with all ESTs]

Unigene Representative Sequence: NM_001130173

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYB (see all 13 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:					-		-																		-		-						-		-				-										-
SP2:					-		-																				-						-		-				-										-
SP3:					-		-																				-		-						-				-										-
SP4:					-		-																				-		-				-						-										-
SP5:					-		-																				-		-				-		-														-

About this scheme

ECgene alternative splicing isoforms for MYB

6 Ensembl transcripts including schematic representations:

ENST00000341911 ENST00000367812 ENST00000367814 ENST00000316528 ENST00000237302 ENST00000339290

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MYB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYB

¹ / ² / ³

12 probe-sets matching MYB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2042_s_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.27	M15024	1.00	1.00	1.00	1
1476_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.51	U22376	0.20	1.00	0.72	1
1473_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.56	U22376	0.20	1.00	0.72	1
1471_at²^{, 3}	U95-A	1	1.00	1.00	0.67	0.43	U22376	0.20	1.00	0.72	1
1475_s_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.95	U22376	0.20	1.00	0.72	1
1474_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.12	U22376	0.20	1.00	0.72	1
1472_g_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.07	U22376	0.20	1.00	0.72	1
41854_at²^{, 3}	U95-A	1	0.94	1.00	0.78	0.91	M13666	0.80	1.00	0.91	1
204798_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005375	0.60	1.00	0.82	1
215152_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AI357042	0.60	1.00	0.82	1
204798_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215152_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks MYB for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATCCTGTGT

SOURCE GeneReport for Unigene cluster: Hs.654446
Expression variation in blood from EXPOLDB for MYB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYB gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYB¹	--	v-myb myeloblastosis viral oncogene homolog (avian)	93.28(n) 94.69(a)	483995 XM_541112.2 XP_541112.2
chimpanzee (Pan troglodytes)	MYB¹	--	v-myb myeloblastosis viral oncogene homolog (avian)	99.79(n) 99.68(a)	463016 XM_518756.2 XP_518756.2
cow (Bos taurus)	MYB¹	--	v-myb myeloblastosis viral oncogene homolog (avian)	92.47(n) 92.83(a)	317776 NM_175050.1 NP_778220.1
mouse (Mus musculus)	Myb^{1, 5}	10 (16.00 cM)⁵	myeloblastosis oncogene^{1, 5}	87.37(n)¹ 91.04(a)¹	17863¹ NM_010848.3¹ NP_034978.3¹ AA170760⁵ AI550390⁵ (see all 34)
chicken (Gallus gallus)	MYB¹	--	v-myb myeloblastosis viral oncogene homolog (avian)	79.84(n) 82.66(a)	396244 NM_205306.1 NP_990637.1

About this table Species with no ortholog for MYB

ENSEMBL Gene Tree for MYB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYB gene

MYBL2² MYBL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/273 NCBI SNPs in MYB are shown (see all 273 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 105)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs210936^1,2	A,C,F,H	135582142(-)	`TTCTTC/TTCCAT`	1	--	ng3¹		7		MN EU EA WA NA	778
	rs210937^1,2	A,C,F,H	135582073(-)	`AGTGCT/CTTGAG`	1	--	ng3¹		7		MN EU EA WA NA	784
--	rs210965^1,2	C,H	135543315(+)	`GAGCAA/C/G/T AGGTG`	1	--	ng5¹		5		MN EU EA WA	602
	rs2230000^1,2	F	135561800(+)	`TTCCAC/ACCCCC`	3	N/T	mis¹ ese³		5		MN EU EA WA	476
	rs2229999^1,2	H	135558637(+)	`CCACAC/TCAGAC`	3	T/I	mis¹ ese³		5		MN EU EA WA	464
--	rs3216774^1,2	C	135581089(+)	`AAAAA-/ACATAA`	3	--	ut3¹		0	--	--	--	--
--	rs5880250^1,2	C	135542246(+)	`AAAAA-/AGGAAA`	1	--	ng5¹ trp³		0	--	--	--	--
	rs7454405^1,2	C	135542313(+)	`CACCTC/GCTAAA`	1	--	ng5¹		0	--	--	--	--
	rs6927965^1,2	F,H	135558752(+)	`AGGTGC/TATGAT`	3	C/C	syn¹ ese³		4		EU EA WA	420
	rs35664708^1,2	F	135580796(-)	`AGCGTC/TCGGGC`	3	R/R	syn¹		1		NA	76

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HapMap Linkage Disequilibrium images for MYB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 189990

10/64 Novoseek disease relationships for MYB gene (see all 64 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloblastosis	73.71	4	12490953 (1), 11080802 (1), 18930885 (1), 8336948 (1)
lymphosarcoma bovine	70.57	2	8116930 (1), 7929419 (1)
myeloid leukemia	69.15	13	12631292 (1), 2088479 (1), 8654374 (1), 11956664 (1) (see all 11)
leukemogenesis	60.86	9	9271390 (1), 15540222 (1), 12384144 (1), 18505338 (1) (see all 6)
leukemia	59.72	62	18195038 (3), 1588953 (3), 1560675 (2), 8967957 (2) (see all 32)
erythroleukemia	54.79	9	8132611 (2), 8496152 (2), 1533276 (1), 1640736 (1) (see all 6)
blast crisis	46.27	9	16797705 (3), 8967957 (2), 9737692 (1), 18550858 (1)
malignant histiocytosis	42.07	1	8352523 (1)
hematopoietic malignancies	40.89	2	10880029 (1), 9258605 (1)
myeloid leukemia chronic	40.18	9	8967957 (2), 16797705 (2), 10678368 (1), 18550858 (1) (see all 5)

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Genetic Association Database: MYB
Human Genome Epidemiology Navigator: MYB (8 documents)
Tumor Gene Database: MYB

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/480 PubMed articles for MYB gene (see all 480 ):

Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. (PubMed id 1944282)^{1, 3, 4} Nicolaides N.C.... Calabretta B. (1991)
The intron 6 G/T polymorphism of c-myb oncogene and the risk for coronary in-stent restenosis. (PubMed id 15221349)^{1, 3, 6} Gross C.M....Praus M. (2004)
Alternative splicing of the human c-myb gene. (PubMed id 2202948)^{1, 3, 4} Westin E.H.... Clarke M.F. (1990)
Transcriptional activation by human c-myb and v-myb genes. (PubMed id 2189102)^{1, 3, 4} Kalkbrenner F.... Moelling K. (1990)
The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. (PubMed id 17599807)^{2, 3} Chen Y....Mo X. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. (PubMed id 10747903)^{3, 4} Tanikawa J.... Ishii S. (2000)
Identification of a second promoter in the human c-myb proto- oncogene. (PubMed id 8302584)^{3, 4} Jacobs S.M.... Westin E.H. (1994)
Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences. (PubMed id 2687764)^{3, 4} Dasgupta P. and Reddy E.P. (1989)
Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. (PubMed id 3540945)^{3, 4} Majello B.... Dalla-Favera R. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4602	HGNC: 7545	AceView: MYB	Ensembl:ENSG00000118513	euGenes: HUgn4602
ECgene: MYB	H-InvDB: MYB

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MYB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MYB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MYB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYB		Antibodies for MYB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MYB)
	Antibodies (MYB)
	Chimera RNAi (MYB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (v-Myb + c-Myb, c-Myb)
	Antibodies (v-Myb + c-Myb, c-Myb)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MYB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MYB

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MYB Gene at Home site.
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MYB Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for MYB

Summaries
for MYB

Genomic Location
for MYB

Proteins
for MYB

Protein Domains/
Families
for MYB

Gene Function
for MYB

Pathways & Interactions
for MYB

Drugs & Compounds
for MYB

Transcripts
for MYB

Expression
for MYB

Orthologs
for MYB

Paralogs
for MYB

SNPs/Variants
for MYB

Disorders & Mutations
for MYB

Medical News
for MYB

Publications
for MYB

Search for MYB

Genome Databases showing MYB

Other Databases showing MYB

Specialized Databases showing MYB

Licensable Technologies
for MYB

Services
for MYB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYB Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor MYB

Summariesfor MYB

Genomic Locationfor MYB

Proteinsfor MYB

Protein Domains/Familiesfor MYB

Gene Functionfor MYB

Pathways & Interactionsfor MYB

Drugs & Compoundsfor MYB

Transcriptsfor MYB

Expression for MYB

Orthologsfor MYB

Paralogsfor MYB

SNPs/Variantsfor MYB

Disorders & Mutationsfor MYB

Medical Newsfor MYB

Publicationsfor MYB

Search for MYB

Genome Databases showing MYB

Other Databases showing MYB

Specialized Databases showing MYB

Licensable Technologiesfor MYB

Servicesfor MYB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYB

Summaries
for MYB

Genomic Location
for MYB

Proteins
for MYB

Protein Domains/
Families
for MYB

Gene Function
for MYB

Pathways & Interactions
for MYB

Drugs & Compounds
for MYB

Transcripts
for MYB

Expression
for MYB

Orthologs
for MYB

Paralogs
for MYB

SNPs/Variants
for MYB

Disorders & Mutations
for MYB

Medical News
for MYB

Publications
for MYB

Licensable Technologies
for MYB

Services
for MYB