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Aliases for MYB Gene

Aliases for MYB Gene

  • MYB Proto-Oncogene, Transcription Factor 2 3 5
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Myb 3 4
  • Transcriptional Activator Myb 3
  • Oncogene AMV 3
  • C-Myb_CDS 3
  • C-Myb 3
  • Cmyb 3
  • EFG 3

External Ids for MYB Gene

Previous GeneCards Identifiers for MYB Gene

  • GC06P135349
  • GC06P135483
  • GC06P135544
  • GC06P133066
  • GC06P135503

Summaries for MYB Gene

Entrez Gene Summary for MYB Gene

  • This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for MYB Gene

MYB (MYB Proto-Oncogene, Transcription Factor) is a Protein Coding gene. Diseases associated with MYB include Acute Basophilic Leukemia and Angiocentric Glioma. Among its related pathways are C-MYB transcription factor network and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for MYB Gene

  • Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Gene Wiki entry for MYB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYB Gene

Genomics for MYB Gene

Regulatory Elements for MYB Gene

Enhancers for MYB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G135179 2 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +2.0 1969 7.0 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 SIN3A ZNF766 ZNF143 ZNF548 ZNF263 MYB ENSG00000224374 ENSG00000232876 HBS1L AHI1 GC06P135183 GC06P135185 GC06P135181
GH06G135083 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -94.3 -94278 5.8 HDGF PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ELK1 ZNF143 ALDH8A1 MYB ENSG00000232876 HBS1L
GH06G135127 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -52.1 -52060 2.3 PKNOX1 FOXA2 EED ETV6 RELB IKZF2 CREM MTA2 CBFB CEBPB MYB ALDH8A1 ENSG00000232876 HBS1L LOC105378010
GH06G135144 1.4 Ensembl ENCODE dbSUPER 12.7 -35.4 -35390 2.0 HDGF CBX3 NFRKB RAD21 GATA2 SCRT2 ETV6 RELB IKZF2 ZNF263 MYB ALDH8A1 MYB-AS1 ENSG00000224374 ENSG00000232876 LOC105378010
GH06G135110 1.3 FANTOM5 ENCODE 12.9 -70.6 -70627 0.3 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 NCOA1 MBD2 SMARCA4 MYB MYB-AS1 AHI1 HBS1L LOC105378010
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYB on UCSC Golden Path with GeneCards custom track

Promoters for MYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000203343 919 3401 ARNT AGO1 SIN3A ZNF766 GLIS2 GATA2 ZNF263 SP3 JUNB TBX21

Genomic Location for MYB Gene

Chromosome:
6
Start:
135,180,981 bp from pter
End:
135,219,173 bp from pter
Size:
38,193 bases
Orientation:
Plus strand

Genomic View for MYB Gene

Genes around MYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYB Gene

Proteins for MYB Gene

  • Protein details for MYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10242-MYB_HUMAN
    Recommended name:
    Transcriptional activator Myb
    Protein Accession:
    P10242
    Secondary Accessions:
    • E9PI07
    • E9PLZ5
    • E9PNA4
    • E9PNL6
    • E9PRS2
    • P78391
    • P78392
    • P78525
    • P78526
    • Q14023
    • Q14024
    • Q708E4
    • Q708E7
    • Q9UE83

    Protein attributes for MYB Gene

    Size:
    640 amino acids
    Molecular mass:
    72341 Da
    Quaternary structure:
    • Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.

    Alternative splice isoforms for MYB Gene

neXtProt entry for MYB Gene

Post-translational modifications for MYB Gene

  • Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
  • Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at posLast=5353, posLast=204204, Lys293, posLast=442442, Lys445, posLast=471471, and Lys480
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYB (Myb)

No data available for DME Specific Peptides for MYB Gene

Domains & Families for MYB Gene

Gene Families for MYB Gene

Graphical View of Domain Structure for InterPro Entry

P10242

UniProtKB/Swiss-Prot:

MYB_HUMAN :
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Domain:
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
genes like me logo Genes that share domains with MYB: view

Function for MYB Gene

Molecular function for MYB Gene

GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis
UniProtKB/Swiss-Prot Function:
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
UniProtKB/Swiss-Prot Induction:
Negatively regulated by microRNA-155 (miR-155).

Gene Ontology (GO) - Molecular Function for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 7987850
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MYB: view
genes like me logo Genes that share phenotypes with MYB: view

Animal Models for MYB Gene

MGI Knock Outs for MYB:

Animal Model Products

CRISPR Products

Transcription Factor Targets for MYB Gene

Selected GeneGlobe predicted Target genes for MYB
Targeted motifs for MYB Gene
HOMER Transcription Factor Regulatory Elements motif MYB
  • Consensus sequence: GGCVGTTR Submotif: canonical Cell Type: ERMYB GEO ID: GSE22095

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for MYB Gene

Localization for MYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYB gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016363 nuclear matrix NAS 3014652
genes like me logo Genes that share ontologies with MYB: view

Pathways & Interactions for MYB Gene

genes like me logo Genes that share pathways with MYB: view

SIGNOR curated interactions for MYB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0000278 mitotic cell cycle IBA --
GO:0001666 response to hypoxia IEA --
GO:0006338 chromatin remodeling IMP 20484083
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MYB: view

Drugs & Compounds for MYB Gene

(35) Drugs for MYB Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
G4460 Pharma 0

(24) Additional Compounds for MYB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYB: view

Transcripts for MYB Gene

Unigene Clusters for MYB Gene

V-myb myeloblastosis viral oncogene homolog (avian):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

Relevant External Links for MYB Gene

GeneLoc Exon Structure for
MYB
ECgene alternative splicing isoforms for
MYB

Expression for MYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYB Gene

This gene is overexpressed in Colon - Transverse (x11.5) and Breast - Mammary Tissue (x5.5).

Protein differential expression in normal tissues from HIPED for MYB Gene

This gene is overexpressed in Monocytes (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYB Gene



Protein tissue co-expression partners for MYB Gene

NURSA nuclear receptor signaling pathways regulating expression of MYB Gene:

MYB

SOURCE GeneReport for Unigene cluster for MYB Gene:

Hs.606320

Evidence on tissue expression from TISSUES for MYB Gene

  • Liver(4.4)
  • Blood(3.2)
  • Bone marrow(3)
  • Intestine(2.2)
  • Kidney(2)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MYB Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Organs:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with MYB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MYB Gene

Orthologs for MYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYB 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia C-MYB 35
  • 93 (a)
OneToOne
MYB 34
  • 92.73 (n)
cow
(Bos Taurus)
Mammalia MYB 34 35
  • 92.47 (n)
oppossum
(Monodelphis domestica)
Mammalia MYB 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myb 34 16 35
  • 86.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYB 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves C-MYB 35
  • 83 (a)
OneToOne
MYB 34
  • 79.84 (n)
lizard
(Anolis carolinensis)
Reptilia MYB 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myb 34
  • 68.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398039 34
zebrafish
(Danio rerio)
Actinopterygii cmyb 34 35
  • 63.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Myb 36 35
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 35
  • 16 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.38177 34
Species where no ortholog for MYB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYB Gene

ENSEMBL:
Gene Tree for MYB (if available)
TreeFam:
Gene Tree for MYB (if available)

Paralogs for MYB Gene

Variants for MYB Gene

Sequence variations from dbSNP and Humsavar for MYB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000154404 -- 135,204,791(+) AGTTG(A/G)CCCCG intron-variant
rs1000191892 -- 135,206,127(+) ATGAA(-/C)CCCAG intron-variant
rs1000380763 -- 135,211,659(+) AAAGT(A/C)TATCA intron-variant
rs1000453080 -- 135,186,605(+) ACAAA(A/G)CACTC intron-variant
rs1000479872 -- 135,219,403(+) GTCTA(A/G)CGGCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MYB Gene

Variant ID Type Subtype PubMed ID
esv3610891 CNV loss 21293372
nsv1122138 CNV deletion 24896259
nsv478838 CNV novel sequence insertion 20440878
nsv5490 CNV insertion 18451855
nsv950512 CNV duplication 24416366

Variation tolerance for MYB Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYB Gene

Human Gene Mutation Database (HGMD)
MYB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYB Gene

Disorders for MYB Gene

MalaCards: The human disease database

(13) MalaCards diseases for MYB Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MYB in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYB

Genetic Association Database (GAD)
MYB
Human Genome Epidemiology (HuGE) Navigator
MYB
Tumor Gene Database (TGDB):
MYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYB
genes like me logo Genes that share disorders with MYB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYB Gene

Publications for MYB Gene

  1. The intron 6 G/T polymorphism of c-myb oncogene and the risk for coronary in-stent restenosis. (PMID: 15221349) Gross C.M. … Praus M. (Basic Res. Cardiol. 2004) 3 22 46 64
  2. Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. (PMID: 1944282) Nicolaides N.C. … Calabretta B. (Mol. Cell. Biol. 1991) 3 4 22 64
  3. Transcriptional activation by human c-myb and v-myb genes. (PMID: 2189102) Kalkbrenner F. … Moelling K. (Oncogene 1990) 3 4 22 64
  4. Alternative splicing of the human c-myb gene. (PMID: 2202948) Westin E.H. … Clarke M.F. (Oncogene 1990) 3 4 22 64
  5. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. (PMID: 23166356) Basso K. … Dalla-Favera R. (J. Exp. Med. 2012) 3 4 64

Products for MYB Gene

  • Addgene plasmids for MYB

Sources for MYB Gene

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