Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYB Gene

Aliases for MYB Gene

  • MYB Proto-Oncogene, Transcription Factor 2 3
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog 2 3 5
  • Proto-Oncogene C-Myb 3 4
  • Oncogene AMV 3
  • C-Myb_CDS 3
  • C-Myb 3
  • Cmyb 3
  • EFG 3

External Ids for MYB Gene

Previous GeneCards Identifiers for MYB Gene

  • GC06P135349
  • GC06P135483
  • GC06P135544
  • GC06P133066
  • GC06P135503

Summaries for MYB Gene

Entrez Gene Summary for MYB Gene

  • This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for MYB Gene

MYB (MYB Proto-Oncogene, Transcription Factor) is a Protein Coding gene. Diseases associated with MYB include acute basophilic leukemia and precursor t-cell acute lymphoblastic leukemia. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is SNAPC4.

UniProtKB/Swiss-Prot for MYB Gene

  • Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Gene Wiki entry for MYB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYB Gene

Genomics for MYB Gene

Regulatory Elements for MYB Gene

Promoters for MYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYB on UCSC Golden Path with GeneCards custom track

Genomic Location for MYB Gene

Chromosome:
6
Start:
135,180,981 bp from pter
End:
135,219,173 bp from pter
Size:
38,193 bases
Orientation:
Plus strand

Genomic View for MYB Gene

Genes around MYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYB Gene

Proteins for MYB Gene

  • Protein details for MYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10242-MYB_HUMAN
    Recommended name:
    Transcriptional activator Myb
    Protein Accession:
    P10242
    Secondary Accessions:
    • E9PI07
    • E9PLZ5
    • E9PNA4
    • E9PNL6
    • E9PRS2
    • P78391
    • P78392
    • P78525
    • P78526
    • Q14023
    • Q14024
    • Q708E4
    • Q708E7
    • Q9UE83

    Protein attributes for MYB Gene

    Size:
    640 amino acids
    Molecular mass:
    72341 Da
    Quaternary structure:
    • Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.

    Alternative splice isoforms for MYB Gene

neXtProt entry for MYB Gene

Proteomics data for MYB Gene at MOPED

Post-translational modifications for MYB Gene

  • Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
  • Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 53, Lys 204, Lys 293, Lys 442, Lys 445, Lys 471, and Lys 480
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYB (Myb)

No data available for DME Specific Peptides for MYB Gene

Domains & Families for MYB Gene

Gene Families for MYB Gene

Graphical View of Domain Structure for InterPro Entry

P10242

UniProtKB/Swiss-Prot:

MYB_HUMAN :
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Domain:
  • Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
  • Contains 3 HTH myb-type DNA-binding domains.
genes like me logo Genes that share domains with MYB: view

Function for MYB Gene

Molecular function for MYB Gene

GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog,involved in hematopoiesis
UniProtKB/Swiss-Prot Function:
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5-YAAC[GT]G-3. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
UniProtKB/Swiss-Prot Induction:
Negatively regulated by microRNA-155 (miR-155).
genes like me logo Genes that share phenotypes with MYB: view

Human Phenotype Ontology for MYB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYB Gene

MGI Knock Outs for MYB:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYB

Transcription Factor Targets for MYB Gene

Selected GeneGlobe predicted Target genes for MYB
Targeted motifs for MYB Gene
HOMER Transcription Factor Regulatory Elements motif MYB
  • Consensus sequence: GGCVGTTR Submotif: canonical Cell Type: ERMYB GEO ID: GSE22095

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Gene Ontology (GO) - Molecular Function for MYB Gene

Localization for MYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYB Gene COMPARTMENTS Subcellular localization image for MYB gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for MYB Gene

Pathways & Interactions for MYB Gene

genes like me logo Genes that share pathways with MYB: view

SIGNOR curated interactions for MYB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 2189102
GO:0045893 positive regulation of transcription, DNA-templated NAS 2189102
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 20531406
GO:0051571 positive regulation of histone H3-K4 methylation IMP 20484083
genes like me logo Genes that share ontologies with MYB: view

Drugs & Compounds for MYB Gene

(31) Drugs for MYB Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
G4460 Pharma 0

(28) Additional Compounds for MYB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYB: view

Transcripts for MYB Gene

Unigene Clusters for MYB Gene

V-myb myeloblastosis viral oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

Relevant External Links for MYB Gene

GeneLoc Exon Structure for
MYB
ECgene alternative splicing isoforms for
MYB

Expression for MYB Gene

mRNA expression in normal human tissues for MYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYB Gene

This gene is overexpressed in Colon - Transverse (x11.5) and Breast - Mammary Tissue (x5.5).

Protein differential expression in normal tissues from HIPED for MYB Gene

This gene is overexpressed in Monocytes (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYB Gene



SOURCE GeneReport for Unigene cluster for MYB Gene Hs.606320

genes like me logo Genes that share expression patterns with MYB: view

Protein tissue co-expression partners for MYB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYB Gene

Orthologs for MYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYB 35
  • 92.47 (n)
  • 92.83 (a)
MYB 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYB 35
  • 92.73 (n)
  • 92.9 (a)
C-MYB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myb 35
  • 86.83 (n)
  • 88.59 (a)
Myb 16
Myb 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYB 35
  • 99.12 (n)
  • 98.95 (a)
MYB 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYB 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYB 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYB 35
  • 79.84 (n)
  • 82.66 (a)
C-MYB 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYB 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myb 35
  • 68.86 (n)
  • 67.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398039 35
zebrafish
(Danio rerio)
Actinopterygii cmyb 35
  • 63.07 (n)
  • 63.36 (a)
cmyb 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 37
  • 62 (a)
Myb 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 16 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.38177 35
Species with no ortholog for MYB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYB Gene

ENSEMBL:
Gene Tree for MYB (if available)
TreeFam:
Gene Tree for MYB (if available)

Paralogs for MYB Gene

Paralogs for MYB Gene

genes like me logo Genes that share paralogs with MYB: view

Variants for MYB Gene

Sequence variations from dbSNP and Humsavar for MYB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_050188 -
VAR_050189 -
rs210792 -- 135,185,384(+) ATAAT(C/T)CTGTT intron-variant
rs210793 -- 135,185,553(+) TTCTT(C/G)TTCCT intron-variant
rs210794 -- 135,185,622(+) AATGT(A/G)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYB Gene

Variant ID Type Subtype PubMed ID
nsv886685 CNV Loss 21882294
nsv5490 CNV Insertion 18451855

Variation tolerance for MYB Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYB Gene

HapMap Linkage Disequilibrium report
MYB
Human Gene Mutation Database (HGMD)
MYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYB Gene

Disorders for MYB Gene

MalaCards: The human disease database

(8) MalaCards diseases for MYB Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute basophilic leukemia
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
tuberculous salpingitis
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
malignant histiocytosis
  • histiocytic medullary reticulosis [obs]
- elite association - COSMIC cancer census association via MalaCards
Search MYB in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYB

Genetic Association Database (GAD)
MYB
Human Genome Epidemiology (HuGE) Navigator
MYB
Tumor Gene Database (TGDB):
MYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYB
genes like me logo Genes that share disorders with MYB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYB Gene

Publications for MYB Gene

  1. Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene. (PMID: 1944282) Nicolaides N.C. … Calabretta B. (Mol. Cell. Biol. 1991) 3 4 23 67
  2. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. (PMID: 19036881) Fang F. … Clevenger C.V. (Endocrinology 2009) 3 23
  3. c-myb stimulates cell growth by regulation of insulin-like growth factor (IGF) and IGF-binding protein-3 in K562 leukemia cells. (PMID: 19427836) Kim M.S. … Lee D.Y. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. (PMID: 19841262) Persson M. … Stenman G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. (PMID: 18195038) O'Rourke J.P. … Ness S.A. (Mol. Cell. Biol. 2008) 3 23

Products for MYB Gene

Sources for MYB Gene

Back to Top

Content