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Aliases for MYADML2 Gene

Aliases for MYADML2 Gene

  • Myeloid Associated Differentiation Marker Like 2 2 3
  • Myeloid-Associated Differentiation Marker-Like 2 5

External Ids for MYADML2 Gene

Previous GeneCards Identifiers for MYADML2 Gene

  • GC17M077490
  • GC17M079897
  • GC17M075298

Summaries for MYADML2 Gene

GeneCards Summary for MYADML2 Gene

MYADML2 (Myeloid Associated Differentiation Marker Like 2) is a Protein Coding gene. An important paralog of this gene is MYADM.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYADML2 Gene

Genomics for MYADML2 Gene

Regulatory Elements for MYADML2 Gene

Enhancers for MYADML2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MYADML2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYADML2 Gene

Chromosome:
17
Start:
81,939,645 bp from pter
End:
81,947,233 bp from pter
Size:
7,589 bases
Orientation:
Minus strand

Genomic View for MYADML2 Gene

Genes around MYADML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYADML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYADML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADML2 Gene

Proteins for MYADML2 Gene

  • Protein details for MYADML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDP7-MADL2_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker-like protein 2
    Protein Accession:
    A6NDP7

    Protein attributes for MYADML2 Gene

    Size:
    307 amino acids
    Molecular mass:
    32967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYADML2 Gene

Post-translational modifications for MYADML2 Gene

No Post-translational modifications

Other Protein References for MYADML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYADML2 Gene

Domains & Families for MYADML2 Gene

Protein Domains for MYADML2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYADML2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NDP7

UniProtKB/Swiss-Prot:

MADL2_HUMAN :
  • Contains 2 MARVEL domains.
  • Belongs to the MAL family.
Domain:
  • Contains 2 MARVEL domains.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADML2: view

No data available for Gene Families for MYADML2 Gene

Function for MYADML2 Gene

Phenotypes for MYADML2 Gene

GenomeRNAi human phenotypes for MYADML2:
genes like me logo Genes that share phenotypes with MYADML2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYADML2 Gene

Localization for MYADML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADML2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYADML2 Gene COMPARTMENTS Subcellular localization image for MYADML2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MYADML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21325632
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADML2: view

Pathways & Interactions for MYADML2 Gene

SuperPathways for MYADML2 Gene

No Data Available

Interacting Proteins for MYADML2 Gene

Gene Ontology (GO) - Biological Process for MYADML2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYADML2 Gene

Drugs & Compounds for MYADML2 Gene

No Compound Related Data Available

Transcripts for MYADML2 Gene

mRNA/cDNA for MYADML2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(644) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYADML2 Gene

Myeloid-associated differentiation marker-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYADML2 Gene

No ASD Table

Relevant External Links for MYADML2 Gene

GeneLoc Exon Structure for
MYADML2
ECgene alternative splicing isoforms for
MYADML2

Expression for MYADML2 Gene

mRNA expression in normal human tissues for MYADML2 Gene

mRNA differential expression in normal tissues according to GTEx for MYADML2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Caudate (basal ganglia) (x4.8), Heart - Left Ventricle (x4.7), Brain - Frontal Cortex (BA9) (x4.5), Brain - Cortex (x4.4), and Muscle - Skeletal (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MYADML2 Gene:

MYADML2

SOURCE GeneReport for Unigene cluster for MYADML2 Gene:

Hs.729645
genes like me logo Genes that share expression patterns with MYADML2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYADML2 Gene

Orthologs for MYADML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYADML2 34
  • 87.4 (n)
  • 91.21 (a)
MYADML2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYADML2 34
  • 88.17 (n)
  • 91.21 (a)
MYADML2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myadml2 34
  • 83.71 (n)
  • 91.53 (a)
Myadml2 16
Myadml2 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYADML2 34
  • 98.7 (n)
  • 99.67 (a)
rat
(Rattus norvegicus)
Mammalia Myadml2 34
  • 84.8 (n)
  • 92.51 (a)
oppossum
(Monodelphis domestica)
Mammalia MYADML2 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYADML2 34
  • 73.09 (n)
  • 73.42 (a)
lizard
(Anolis carolinensis)
Reptilia MYADML2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myadml2 34
  • 63.42 (n)
  • 62.75 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570494 34
  • 65.78 (n)
  • 62.33 (a)
MYADML2 35
  • 62 (a)
OneToOne
Species where no ortholog for MYADML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADML2 Gene

ENSEMBL:
Gene Tree for MYADML2 (if available)
TreeFam:
Gene Tree for MYADML2 (if available)

Paralogs for MYADML2 Gene

Paralogs for MYADML2 Gene

(2) SIMAP similar genes for MYADML2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYADML2: view

Variants for MYADML2 Gene

Sequence variations from dbSNP and Humsavar for MYADML2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3760532 -- 81,939,573(+) AGCAC(A/G)CTAGG downstream-variant-500B
rs113672094 -- 81,939,496(+) AGGCT(G/T)CTCAG downstream-variant-500B
rs116669135 -- 81,939,369(+) TGGGC(A/C/G)TGGGG downstream-variant-500B
rs141374427 -- 81,939,430(+) CCCGT(C/T)GGAGC downstream-variant-500B
rs143034182 -- 81,939,653(+) GTATA(A/C)ATGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYADML2 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2338985 CNV deletion 18987734
esv2658619 CNV deletion 23128226
esv2716464 CNV deletion 23290073
esv2716465 CNV deletion 23290073
esv29964 CNV loss 17803354
esv32874 CNV loss 17666407
esv3641409 CNV loss 21293372
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for MYADML2 Gene

Gene Damage Index Score: 4.28; 62.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYADML2 Gene

Human Gene Mutation Database (HGMD)
MYADML2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYADML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYADML2 Gene

Disorders for MYADML2 Gene

Relevant External Links for MYADML2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYADML2

No disorders were found for MYADML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADML2 Gene

Publications for MYADML2 Gene

  1. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. (PMID: 21325632) Aranda J.F. … Alonso M.A. (Mol. Biol. Cell 2011) 3 65
  2. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3 65
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for MYADML2 Gene

Sources for MYADML2 Gene

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