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MYADML2 Gene

protein-coding   GIFtS: 31
GCID: GC17M079897

Myeloid-Associated Differentiation Marker-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid-Associated Differentiation Marker-Like 21 2
Myeloid-Associated Differentiation Marker-Like Protein 22

External Ids:    HGNC: 345481   Entrez Gene: 2552752   Ensembl: ENSG000001851057   UniProtKB: A6NDP73   

Export aliases for MYADML2 gene to outside databases

Previous GC identifers: GC17M077490 GC17M075298


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYADML2 Gene:
MYADML2 (myeloid-associated differentiation marker-like 2) is a protein-coding gene. An important paralog of this gene is MYADM.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MYADML2 gene promoter:
         E2F-4   E2F-3a   p53   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYADML2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYADML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

MYADML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYADML2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079897:  view genomic region     (about GC identifiers)

Start:
79,897,521 bp from pter      End:
79,905,109 bp from pter
Size:
7,589 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MADL2_HUMAN, A6NDP7 (See protein sequence)
Recommended Name: Myeloid-associated differentiation marker-like protein 2  
Size: 307 amino acids; 32967 Da

Explore the universe of human proteins at neXtProt for MYADML2: NX_A6NDP7

REFSEQ proteins: NP_001138585.2  
ENSEMBL proteins: 
 ENSP00000386702   ENSP00000327718  

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antibodies-online kits for MYADML2 (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008253 Marvel

Graphical View of Domain Structure for InterPro Entry A6NDP7

ProtoNet protein and cluster: A6NDP7

UniProtKB/Swiss-Prot: MADL2_HUMAN, A6NDP7
Similarity: Belongs to the MAL family
Similarity: Contains 2 MARVEL domains


Find genes that share domains with MYADML2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MYADML2

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MADL2_HUMAN, A6NDP7: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MYADML2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYADML2
Interactions:

    Search GeneGlobe Interaction Network for MYADML2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MYADML2 (MADL2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYADML2 gene: 
NM_001145113.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000409745(uc010wvf.1) ENST00000330655
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Selected AceView cDNA sequences (see all 644):

CR607700 BQ436804 BG284558 T29363 AW291872 NM_153824 BQ064479 CR615796 
BM748240 BQ888678 BQ061900 BQ669250 BM783387 T07966 AU132733 CN484703 
BM784148 CF146624 BU501007 CR605144 BM742284 BQ642274 AL561248 BM752975 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYADML2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGCTAGAA
MYADML2 Expression
About this image

MYADML2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MYADML2 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Myadml21 , 5 myeloid-associated differentiation marker-like 21, 5 83.71(n)1
91.53(a)1
  11 (84.37 cM)5
685151  NM_026751.11  NP_081027.11 
 1206460315 
chicken
(Gallus gallus)
Aves MYADML21 myeloid-associated differentiation marker-like 2 73.09(n)
73.42(a)
  427806  XM_004946153.1  XP_004946210.1 
lizard
(Anolis carolinensis)
Reptilia MYADML26
myeloid-associated differentiation marker-like 2
67(a)
1 ↔ 1
2(118406271-118407209)
tropical clawed frog
(Xenopus tropicalis)
Amphibia myadml21 myeloid-associated differentiation marker-like 2 63.42(n)
62.75(a)
  100486424  XM_002937307.2  XP_002937353.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5704941 myeloid-associated differentiation marker-like protein more 65.78(n)
62.33(a)
  570494  XM_005171651.1  XP_005171708.1 


ENSEMBL Gene Tree for MYADML2 (if available)
TreeFam Gene Tree for MYADML2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MYADML2 gene
MYADM2  
2 SIMAP similar genes for MYADML2 using alignment to 1 protein entry:     MADL2_HUMAN:
MYADM    tmp_locus_39

Find genes that share paralogs with MYADML2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MYADML2 (see all 228)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1446177001,2
C--79898639(+) CCCTCA/GCAGAG 1 -- ut310--------
rs22930981,2
C,F,A,H--79898644(-) CCAGGC/TTCTGC 1 -- ut3119Minor allele frequency- T:0.17EA NS NA WA CSA 3477
rs1416254781,2
--79898656(+) GCTGGG/TGGCCA 1 -- ut310--------
rs1452568881,2
C--79898714(+) GAAGCA/GAATCC 2 R C mis10--------
rs1819847771,2
C--79898737(+) CGAGGC/TCAACG 2 D G mis10--------
rs1476050531,2
--79898763(+) TTGACA/GTAGGT 2 Y syn10--------
rs1408864681,2
C--79898812(+) TGCCCC/TGAGCA 2 Q R mis10--------
rs1501540511,2
C--79898821(+) CACAGC/TTGGGG 2 N S mis10--------
rs1456197261,2
C--79898830(+) GGGGCC/TGTTTG 2 Q R mis10--------
rs1870295461,2
--79898855(+) GGGATC/TGAAAC 2 N D mis10--------

HapMap Linkage Disequilibrium report for MYADML2 (79897521 - 79905109 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MYADML2 (see all 25):    About this table    
Variant IDTypeSubtypePubMed ID
esv2716465CNV Deletion23290073
esv2338985CNV Deletion18987734
esv2658619CNV Deletion23128226
esv2716464CNV Deletion23290073
nsv909134CNV Loss21882294
dgv3341n71CNV Loss21882294
esv32874CNV Loss17666407
dgv3333n71CNV Loss21882294
nsv833569CNV Loss17160897
nsv909161CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYADML2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MYADML2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 255275 HGNC: 34548 AceView: PYCR1 Ensembl:ENSG00000185105 euGenes: HUgn255275
ECgene: MYADML2 H-InvDB: MYADML2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYADML2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYADML2 gene:
Search GeneIP for patents involving MYADML2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for MYADML2
 antibodies-online antibodies for MYADML2
 antibodies-online kits for MYADML2 (8 products)
  Search antibodies-online for peptides for MYADML2
  Search antibodies-online for proteins for MYADML2
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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