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Aliases for MYADML2 Gene

Aliases for MYADML2 Gene

  • Myeloid-Associated Differentiation Marker-Like 2 2 3

External Ids for MYADML2 Gene

Previous GeneCards Identifiers for MYADML2 Gene

  • GC17M077490
  • GC17M079897
  • GC17M075298

Summaries for MYADML2 Gene

GeneCards Summary for MYADML2 Gene

MYADML2 (Myeloid-Associated Differentiation Marker-Like 2) is a Protein Coding gene. An important paralog of this gene is MYADM.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYADML2 Gene

Genomics for MYADML2 Gene

Regulatory Elements for MYADML2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYADML2 Gene

81,939,645 bp from pter
81,947,233 bp from pter
7,589 bases
Minus strand

Genomic View for MYADML2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYADML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADML2 Gene

Proteins for MYADML2 Gene

  • Protein details for MYADML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myeloid-associated differentiation marker-like protein 2
    Protein Accession:

    Protein attributes for MYADML2 Gene

    307 amino acids
    Molecular mass:
    32967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYADML2 Gene

Proteomics data for MYADML2 Gene at MOPED

Post-translational modifications for MYADML2 Gene

No Post-translational modifications

Other Protein References for MYADML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYADML2 Gene

Domains & Families for MYADML2 Gene

Protein Domains for MYADML2 Gene


Suggested Antigen Peptide Sequences for MYADML2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 MARVEL domains.
  • Belongs to the MAL family.
  • Contains 2 MARVEL domains.
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADML2: view

No data available for Gene Families for MYADML2 Gene

Function for MYADML2 Gene

Phenotypes for MYADML2 Gene

GenomeRNAi human phenotypes for MYADML2:
genes like me logo Genes that share phenotypes with MYADML2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYADML2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYADML2 Gene

Localization for MYADML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADML2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MYADML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21325632
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADML2: view

No data available for Subcellular locations from COMPARTMENTS for MYADML2 Gene

Pathways & Interactions for MYADML2 Gene

SuperPathways for MYADML2 Gene

No Data Available

Interacting Proteins for MYADML2 Gene

Gene Ontology (GO) - Biological Process for MYADML2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MYADML2 Gene

Drugs & Compounds for MYADML2 Gene

No Compound Related Data Available

Transcripts for MYADML2 Gene

mRNA/cDNA for MYADML2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(644) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYADML2 Gene

Myeloid-associated differentiation marker-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYADML2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYADML2 Gene

No ASD Table

Relevant External Links for MYADML2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYADML2 Gene

mRNA expression in normal human tissues for MYADML2 Gene

mRNA differential expression in normal tissues according to GTEx for MYADML2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Caudate (basal ganglia) (x4.8), Heart - Left Ventricle (x4.7), Brain - Frontal Cortex (BA9) (x4.5), Brain - Cortex (x4.4), and Muscle - Skeletal (x4.1).

SOURCE GeneReport for Unigene cluster for MYADML2 Gene Hs.729645

genes like me logo Genes that share expression patterns with MYADML2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MYADML2 Gene

Orthologs for MYADML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADML2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYADML2 35
  • 87.4 (n)
  • 91.21 (a)
  • 91 (a)
(Canis familiaris)
Mammalia MYADML2 35
  • 88.17 (n)
  • 91.21 (a)
  • 91 (a)
(Mus musculus)
Mammalia Myadml2 35
  • 83.71 (n)
  • 91.53 (a)
Myadml2 16
Myadml2 36
  • 76 (a)
(Pan troglodytes)
Mammalia MYADML2 35
  • 98.7 (n)
  • 99.67 (a)
(Rattus norvegicus)
Mammalia Myadml2 35
  • 84.8 (n)
  • 92.51 (a)
(Monodelphis domestica)
Mammalia MYADML2 36
  • 81 (a)
(Gallus gallus)
Aves MYADML2 35
  • 73.09 (n)
  • 73.42 (a)
(Anolis carolinensis)
Reptilia MYADML2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myadml2 35
  • 63.42 (n)
  • 62.75 (a)
(Danio rerio)
Actinopterygii LOC570494 35
  • 65.78 (n)
  • 62.33 (a)
  • 62 (a)
Species with no ortholog for MYADML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADML2 Gene

Gene Tree for MYADML2 (if available)
Gene Tree for MYADML2 (if available)

Paralogs for MYADML2 Gene

Paralogs for MYADML2 Gene

(2) SIMAP similar genes for MYADML2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYADML2: view

Variants for MYADML2 Gene

Sequence variations from dbSNP and Humsavar for MYADML2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3760532 -- 81,939,573(+) AGCAC(A/G)CTAGG downstream-variant-500B
rs113672094 -- 81,939,496(+) AGGCT(G/T)CTCAG downstream-variant-500B
rs116669135 -- 81,939,369(+) TGGGC(A/C/G)TGGGG downstream-variant-500B
rs141374427 -- 81,939,430(+) CCCGT(C/T)GGAGC downstream-variant-500B
rs143034182 -- 81,939,653(+) GTATA(A/C)ATGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYADML2 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897
esv32874 CNV Loss 17666407
esv2658619 CNV Deletion 23128226
esv2716464 CNV Deletion 23290073
esv2338985 CNV Deletion 18987734
esv2716465 CNV Deletion 23290073

Variation tolerance for MYADML2 Gene

Gene Damage Index Score: 4.28; 62.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYADML2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYADML2 Gene

Disorders for MYADML2 Gene

Relevant External Links for MYADML2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYADML2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADML2 Gene

Publications for MYADML2 Gene

  1. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. (PMID: 21325632) Aranda J.F. … Alonso M.A. (Mol. Biol. Cell 2011) 67
  2. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 67
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for MYADML2 Gene

Sources for MYADML2 Gene

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