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MYADML Gene

pseudogene   GIFtS: 22
GCID: GC02M033862

Myeloid-Associated Differentiation Marker-Like (Pseudogene)

(Previous name: myeloid-associated differentiation marker-like)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid-Associated Differentiation Marker-Like (Pseudogene)1 2
Myeloid-Associated Differentiation Marker-Like1

External Ids:    HGNC: 310191   Entrez Gene: 1513252   Ensembl: ENSG000002396497   

Export aliases for MYADML gene to outside databases

Previous GC identifers: GC02U900520 GC02M033925 GC02M033804 GC02M033685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYADML Gene:
MYADML (myeloid-associated differentiation marker-like (pseudogene)) is a pseudogene. Diseases associated with MYADML include hypertension.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYADML gene promoter:
         STAT1   p53   STAT1beta   FOXD3   LUN-1   Ik-3   STAT1alpha   HNF-4alpha1   FOXL1   STAT2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYADML


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22.3

MYADML Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYADML gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M033862:  view genomic region     (about GC identifiers)

Start:
33,947,788 bp from pter      End:
33,953,284 bp from pter
Size:
5,497 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYADML
Interactions:

    Search GeneGlobe Interaction Network for MYADML

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MYADML



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MYADML gene: 
NM_207329.1  

Unigene Cluster for MYADML:

Myeloid-associated differentiation marker-like (pseudogene)
Hs.528847  [show with all ESTs]
Unigene Representative Sequence: BC031088
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000490394 ENST00000474610(uc002rpb.3) ENST00000491596 ENST00000322472

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Additional mRNA sequence: 

AK057470.1 BC031088.1 BC038980.1 NR_003143.2 

1 DOTS entry:

DT.95154051 

12 AceView cDNA sequences:

BI830002 AW628593 BI461933 NM_207329 AK057470 BC038980 BC031088 BM554082 
CD557262 BI562168 AW181957 AA868919 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYADML expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTCCGAGC
MYADML Expression
About this image

MYADML Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.528847
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MYADML (if available)
TreeFam Gene Tree for MYADML (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MYADML (see all 136)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1136365881,2
C--33950694(+) TTTTTA/C/TAGAGA 1 -- int11WA 2
rs1426484261,2
--33950764(+) CCTCTG/TCCTCC 1 -- int10--------
rs67130421,2
C,F,A,H--33950817(+) ggactA/Gtaggc 1 -- int19Minor allele frequency- G:0.21NA WA CSA 19
rs124732631,2
C,F,A,H--33950831(+) CGCCAC/TCACGC 1 -- int16Minor allele frequency- T:0.50NA CSA 14
rs1835061461,2
--33950834(+) CATCAC/TGCTGG 1 -- int10--------
rs1431460781,2
C--33950982(+) TTTTT-/TTTAAAG 1 -- int10--------
rs583741311,2
C--33951004(+) TTTTT-/T/TT  
        
AAAGG
1 -- int11NA 2
rs728570341,2
C,F--33951029(+) CTGCCC/TTCATG 1 -- int12Minor allele frequency- T:0.20WA 120
rs728570361,2
C--33951088(+) GAAGGG/ACGGAA 1 -- int12Minor allele frequency- A:0.06WA 120
rs2000455791,2
C--33951145(+) ATTTAC/TTTACT 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for MYADML (33947788 - 33953284 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MYADML:    About this table    
Variant IDTypeSubtypePubMed ID
nsv873796CNV Loss21882294
nsv214925CNV Loss16902084
dgv4077n71CNV Gain21882294
nsv873793CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for MYADML

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for MYADML:    
About MalaCards
hypertension


MYADML for disorders           About GeneDecksing

Genetic Association Database (GAD): MYADML

Export disorders for MYADML gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYADML gene integrated from 10 sources:
(articles sorted by number of sources associating them with MYADML)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PubMed id 22116950)1 Schuh-Huerta S.M....Reijo Pera R.A. (Hum. Reprod. 2012)
  2. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. (PubMed id 19421330)4 Yang H.C....Pan W.H. (PLoS ONE 2009)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 151325 HGNC: 31019 AceView: MYADML Ensembl:ENSG00000239649 euGenes: HUgn151325
ECgene: MYADML H-InvDB: MYADML

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYADML Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYADML gene:
Search GeneIP for patents involving MYADML

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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