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Aliases for MYADM Gene

Aliases for MYADM Gene

  • Myeloid-Associated Differentiation Marker 2 3 5
  • Myeloid Upregulated Protein 3
  • Protein SB135 4
  • SB135 3

External Ids for MYADM Gene

Previous GeneCards Identifiers for MYADM Gene

  • GC00U990550
  • GC19P059062
  • GC19P054369
  • GC19P050688

Summaries for MYADM Gene

GeneCards Summary for MYADM Gene

MYADM (Myeloid-Associated Differentiation Marker) is a Protein Coding gene. An important paralog of this gene is MYADML2.

Gene Wiki entry for MYADM Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYADM Gene

Genomics for MYADM Gene

Regulatory Elements for MYADM Gene

Enhancers for MYADM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYADM on UCSC Golden Path with GeneCards custom track

Genomic Location for MYADM Gene

Chromosome:
19
Start:
53,865,584 bp from pter
End:
53,876,437 bp from pter
Size:
10,854 bases
Orientation:
Plus strand

Genomic View for MYADM Gene

Genes around MYADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADM Gene

Proteins for MYADM Gene

  • Protein details for MYADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S97-MYADM_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker
    Protein Accession:
    Q96S97
    Secondary Accessions:
    • B2RE58
    • Q542Z1
    • Q7Z507
    • Q8N9R4
    • Q96CS6
    • Q96SK9

    Protein attributes for MYADM Gene

    Size:
    322 amino acids
    Molecular mass:
    35274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97182.1; Type=Frameshift; Positions=228, 277, 278; Evidence={ECO:0000305}; Sequence=BAB55302.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYADM Gene

Proteomics data for MYADM Gene at MOPED

Post-translational modifications for MYADM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYADM Gene

Domains & Families for MYADM Gene

Protein Domains for MYADM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MYADM Gene

Graphical View of Domain Structure for InterPro Entry

Q96S97

UniProtKB/Swiss-Prot:

MYADM_HUMAN :
  • Contains 2 MARVEL domains.
  • Belongs to the MAL family.
Domain:
  • Contains 2 MARVEL domains.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADM: view

No data available for Gene Families for MYADM Gene

Function for MYADM Gene

genes like me logo Genes that share phenotypes with MYADM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MYADM

miRNA for MYADM Gene

miRTarBase miRNAs that target MYADM

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYADM Gene

Localization for MYADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADM Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYADM Gene COMPARTMENTS Subcellular localization image for MYADM gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030864 cortical actin cytoskeleton IDA 21325632
genes like me logo Genes that share ontologies with MYADM: view

Pathways & Interactions for MYADM Gene

SuperPathways for MYADM Gene

No Data Available

Interacting Proteins for MYADM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337222%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000337222 for MYADM Gene via STRING

Gene Ontology (GO) - Biological Process for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 23264465
GO:0030335 positive regulation of cell migration IMP 21325632
GO:0030837 negative regulation of actin filament polymerization IMP 23264465
GO:0045217 NOT cell-cell junction maintenance IMP 23264465
GO:0061028 establishment of endothelial barrier IMP 23264465
genes like me logo Genes that share ontologies with MYADM: view

No data available for Pathways by source and SIGNOR curated interactions for MYADM Gene

Drugs & Compounds for MYADM Gene

No Compound Related Data Available

Transcripts for MYADM Gene

Unigene Clusters for MYADM Gene

Myeloid-associated differentiation marker:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYADM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for MYADM Gene

GeneLoc Exon Structure for
MYADM
ECgene alternative splicing isoforms for
MYADM

Expression for MYADM Gene

mRNA expression in normal human tissues for MYADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYADM Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for MYADM Gene

This gene is overexpressed in Nasal epithelium (20.0) and Colon muscle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYADM Gene



SOURCE GeneReport for Unigene cluster for MYADM Gene Hs.380906

mRNA Expression by UniProt/SwissProt for MYADM Gene

Q96S97-MYADM_HUMAN
Tissue specificity: Widely expressed. Not detected in thymus.
genes like me logo Genes that share expression patterns with MYADM: view

Protein tissue co-expression partners for MYADM Gene

Primer Products

Orthologs for MYADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYADM 35
  • 86.44 (n)
  • 89.44 (a)
-- 36
  • 52 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
MYADM 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100855913 35
  • 87.16 (n)
  • 92.24 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Myadm 35
  • 80.24 (n)
  • 84.77 (a)
Myadm 16
Myadm 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYADM 35
  • 99.28 (n)
  • 99.07 (a)
MYADM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myadm 35
  • 80.79 (n)
  • 85.1 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MYADM 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myadm 35
  • 59.42 (n)
  • 54.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29941 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
si:dkeyp-67a8.2 35
  • 59.37 (n)
  • 56.57 (a)
MYADM (1 of 2) 36
  • 49 (a)
OneToMany
MYADM (2 of 2) 36
  • 53 (a)
OneToMany
Species with no ortholog for MYADM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADM Gene

ENSEMBL:
Gene Tree for MYADM (if available)
TreeFam:
Gene Tree for MYADM (if available)

Paralogs for MYADM Gene

Paralogs for MYADM Gene

(2) SIMAP similar genes for MYADM Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MYADM Gene

genes like me logo Genes that share paralogs with MYADM: view

Variants for MYADM Gene

Sequence variations from dbSNP and Humsavar for MYADM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs844114 -- 53,876,022(+) TGTTT(G/T)GTTTT utr-variant-3-prime
rs7409372 -- 53,875,214(+) tgtgt(A/G)tgtgt utr-variant-3-prime
rs7409422 -- 53,875,215(+) gtgtg(C/T)gtgtg utr-variant-3-prime
rs8104891 -- 53,872,868(+) TCCCT(G/T)GGGGA intron-variant
rs864858 -- 53,876,256(+) TACAT(A/T)ACGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYADM Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833876 CNV Loss 17160897
esv2663412 CNV Deletion 23128226
nsv912389 CNV Loss 21882294
esv2718842 CNV Deletion 23290073
esv2718843 CNV Deletion 23290073

Variation tolerance for MYADM Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYADM Gene

Disorders for MYADM Gene

Relevant External Links for MYADM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYADM

No disorders were found for MYADM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADM Gene

Publications for MYADM Gene

  1. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all- trans retinoic acid. (PMID: 12075932) Cui W. … Zhao S. (Mol. Biol. Rep. 2001) 2 3 4 23 67
  2. Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. (PMID: 10733104) Pettersson M. … JAPnsson J.I. (J. Leukoc. Biol. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. (PMID: 23264465) Aranda J.F. … MillA!n J. (Mol. Biol. Cell 2013) 3

Products for MYADM Gene

Sources for MYADM Gene

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