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Aliases for MYADM Gene

Aliases for MYADM Gene

  • Myeloid-Associated Differentiation Marker 2 3
  • Myeloid Upregulated Protein 3
  • Protein SB135 4
  • SB135 3

External Ids for MYADM Gene

Summaries for MYADM Gene

GeneCards Summary for MYADM Gene

MYADM (Myeloid-Associated Differentiation Marker) is a Protein Coding gene. An important paralog of this gene is MYADML2.

Gene Wiki entry for MYADM Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYADM Gene

Genomics for MYADM Gene

Genomic Location for MYADM Gene

Start:
53,866,223 bp from pter
End:
53,876,437 bp from pter
Size:
10,215 bases
Orientation:
Plus strand

Genomic View for MYADM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADM Gene

Regulatory Elements for MYADM Gene

Proteins for MYADM Gene

  • Protein details for MYADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S97-MYADM_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker
    Protein Accession:
    Q96S97
    Secondary Accessions:
    • B2RE58
    • Q542Z1
    • Q7Z507
    • Q8N9R4
    • Q96CS6
    • Q96SK9

    Protein attributes for MYADM Gene

    Size:
    322 amino acids
    Molecular mass:
    35274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97182.1; Type=Frameshift; Positions=228, 277, 278; Evidence={ECO:0000305}; Sequence=BAB55302.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYADM Gene

Proteomics data for MYADM Gene at MOPED

Post-translational modifications for MYADM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYADM Gene

Domains for MYADM Gene

Protein Domains for MYADM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MYADM Gene

Graphical View of Domain Structure for InterPro Entry

Q96S97

UniProtKB/Swiss-Prot:

MYADM_HUMAN
Domain:
  • Contains 2 MARVEL domains.:
    • Q96S97
Family:
  • Belongs to the MAL family.:
    • Q96S97
genes like me logo Genes that share domains with MYADM: view

No data available for Gene Families for MYADM Gene

Function for MYADM Gene

Gene Ontology (GO) - Molecular Function for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MYADM: view

miRNA for MYADM Gene

miRTarBase miRNAs that target MYADM

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYADM Gene

Localization for MYADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADM Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYADM Gene COMPARTMENTS Subcellular localization image for MYADM gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 21325632
GO:0005886 plasma membrane IMP 21325632
GO:0005911 cell-cell junction IDA 23264465
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADM: view

Pathways for MYADM Gene

SuperPathways for MYADM Gene

No Data Available

Interacting Proteins for MYADM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337222%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000337222 for MYADM Gene via STRING

Gene Ontology (GO) - Biological Process for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 23264465
GO:0010629 negative regulation of gene expression IMP 23264465
GO:0010810 NOT regulation of cell-substrate adhesion IMP 21325632
GO:0030335 positive regulation of cell migration IMP 21325632
GO:0030837 negative regulation of actin filament polymerization IMP 23264465
genes like me logo Genes that share ontologies with MYADM: view

No data available for Pathways by source for MYADM Gene

Transcripts for MYADM Gene

Unigene Clusters for MYADM Gene

Myeloid-associated differentiation marker:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYADM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for MYADM Gene

GeneLoc Exon Structure for
MYADM
ECgene alternative splicing isoforms for
MYADM

Expression for MYADM Gene

mRNA expression in normal human tissues for MYADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYADM Gene

This gene is overexpressed in Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYADM Gene

SOURCE GeneReport for Unigene cluster for MYADM Gene Hs.380906

mRNA Expression by UniProt/SwissProt for MYADM Gene

Q96S97-MYADM_HUMAN
Tissue specificity: Widely expressed. Not detected in thymus.
genes like me logo Genes that share expressions with MYADM: view

Orthologs for MYADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYADM 35
  • 99.28 (n)
  • 99.07 (a)
MYADM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
MYADM 35
  • 86.44 (n)
  • 89.44 (a)
MYADM 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
LOC100855913 35
  • 87.16 (n)
  • 92.24 (a)
mouse
(Mus musculus)
Mammalia Myadm 35
  • 80.24 (n)
  • 84.77 (a)
Myadm 16
Myadm 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myadm 35
  • 80.79 (n)
  • 85.1 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MYADM 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29941 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myadm 35
  • 59.42 (n)
  • 54.52 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
MYADM (1 of 2) 36
  • 49 (a)
OneToMany
MYADM (2 of 2) 36
  • 53 (a)
OneToMany
si:dkeyp-67a8.2 35
  • 59.37 (n)
  • 56.57 (a)
Species with no ortholog for MYADM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADM Gene

ENSEMBL:
Gene Tree for MYADM (if available)
TreeFam:
Gene Tree for MYADM (if available)

Paralogs for MYADM Gene

Paralogs for MYADM Gene

Selected SIMAP similar genes for MYADM Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MYADM Gene

genes like me logo Genes that share paralogs with MYADM: view

Variants for MYADM Gene

Sequence variations from dbSNP and Humsavar for MYADM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8604 -- 53,876,319(+) AATCC(C/G/T)TGGAG utr-variant-3-prime
rs12035 -- 53,874,994(+) CCTGT(C/T)GGCTT utr-variant-3-prime
rs13869 -- 53,874,988(-) ACAGG(C/T)AACCC utr-variant-3-prime
rs167416 -- 53,870,625(-) CTTCG(C/T)GGCAG intron-variant, utr-variant-5-prime
rs307934 -- 53,874,775(+) TCTTT(C/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYADM Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833876 CNV Loss 17160897
esv2663412 CNV Deletion 23128226
nsv912389 CNV Loss 21882294
esv2718842 CNV Deletion 23290073
esv2718843 CNV Deletion 23290073

Relevant External Links for MYADM Gene

HapMap Linkage Disequilibrium report
MYADM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYADM Gene

Disorders for MYADM Gene

No disorders were found for MYADM Gene.

No data available for UniProtKB/Swiss-Prot for MYADM Gene

Publications for MYADM Gene

  1. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all- trans retinoic acid. (PMID: 12075932) Cui W. … Zhao S. (Mol. Biol. Rep. 2001) 2 3 4 23
  2. Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. (PMID: 10733104) Pettersson M. … JAPnsson J.I. (J. Leukoc. Biol. 2000) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MYADM Gene

Sources for MYADM Gene

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