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Aliases for MYADM Gene

Aliases for MYADM Gene

  • Myeloid Associated Differentiation Marker 2 3 5
  • Myeloid-Associated Differentiation Marker 3
  • Myeloid Upregulated Protein 3
  • Protein SB135 4
  • SB135 3

External Ids for MYADM Gene

Previous GeneCards Identifiers for MYADM Gene

  • GC00U990550
  • GC19P059062
  • GC19P054369
  • GC19P050688
  • GC19P053866
  • GC19P053867
  • GC19P053897

Summaries for MYADM Gene

GeneCards Summary for MYADM Gene

MYADM (Myeloid Associated Differentiation Marker) is a Protein Coding gene. An important paralog of this gene is MYADML2.

Gene Wiki entry for MYADM Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYADM Gene

Genomics for MYADM Gene

Regulatory Elements for MYADM Gene

Enhancers for MYADM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053864 1.8 FANTOM5 ENCODE dbSUPER 15.2 +3.3 3331 9.8 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF845 ZNF765 ZNF816 ENSG00000269001 ENSG00000235681 ZNF813 TPM3P6 LENG8-AS1 MYADM ZNF525
GH19G053889 1.3 Ensembl ENCODE dbSUPER 18.5 +24.4 24425 1.2 KLF1 ZNF384 POLR2A PATZ1 SCRT2 PRDM10 KLF8 CREM TCF7L2 SCRT1 MYADM LOC105372457 ENSG00000232324 PRKCG CACNG7
GH19G054018 1.6 FANTOM5 Ensembl ENCODE 11.1 +155.5 155534 6.8 PKNOX1 FOXA2 ATF1 CREB3L1 ARID4B SIN3A TCF12 GTF3C2 ZNF302 GATA2 LILRB3 ZNF845 ZNF525 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF765 PRPF31 VSTM1 LILRA5
GH19G054270 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +406.3 406317 2.2 ZNF777 ZNF316 PKNOX1 ZNF114 CUX1 NFE2 ZNF112 LAIR1 LILRB2 OSCAR MYADM LILRB3 LILRB1 LILRA5 VSTM1 LILRB4 NLRP12
GH19G054199 1.9 FANTOM5 ENCODE dbSUPER 8.1 +340.1 340127 12.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 LILRB5 RPS9 PRPF31 LILRB3 LILRA6 LILRA2 LILRA4 VSTM1 LILRA5 ENSG00000249189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYADM on UCSC Golden Path with GeneCards custom track

Promoters for MYADM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111414 1016 801 TBP FUS AGO1 KLF17 DMAP1 ZNF48 RARA GATA4 ZNF766 ZNF391

Genomic Location for MYADM Gene

Chromosome:
19
Start:
53,865,584 bp from pter
End:
53,876,437 bp from pter
Size:
10,854 bases
Orientation:
Plus strand

Genomic View for MYADM Gene

Genes around MYADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADM Gene

Proteins for MYADM Gene

  • Protein details for MYADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S97-MYADM_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker
    Protein Accession:
    Q96S97
    Secondary Accessions:
    • B2RE58
    • Q542Z1
    • Q7Z507
    • Q8N9R4
    • Q96CS6
    • Q96SK9

    Protein attributes for MYADM Gene

    Size:
    322 amino acids
    Molecular mass:
    35274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97182.1; Type=Frameshift; Positions=228, 277, 278; Evidence={ECO:0000305}; Sequence=BAB55302.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYADM Gene

Post-translational modifications for MYADM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYADM Gene

Domains & Families for MYADM Gene

Protein Domains for MYADM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MYADM Gene

Graphical View of Domain Structure for InterPro Entry

Q96S97

UniProtKB/Swiss-Prot:

MYADM_HUMAN :
  • Belongs to the MAL family.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADM: view

No data available for Gene Families for MYADM Gene

Function for MYADM Gene

Gene Ontology (GO) - Molecular Function for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MYADM: view
genes like me logo Genes that share phenotypes with MYADM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MYADM

CRISPR Products

miRNA for MYADM Gene

miRTarBase miRNAs that target MYADM

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYADM Gene

Localization for MYADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADM Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYADM gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 2

Gene Ontology (GO) - Cellular Components for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 21325632
GO:0005886 plasma membrane IMP 21325632
GO:0005911 cell-cell junction IDA 23264465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADM: view

Pathways & Interactions for MYADM Gene

SuperPathways for MYADM Gene

No Data Available

Interacting Proteins for MYADM Gene

Gene Ontology (GO) - Biological Process for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 23264465
GO:0010629 negative regulation of gene expression IMP 23264465
GO:0010810 NOT regulation of cell-substrate adhesion IMP 21325632
GO:0030335 positive regulation of cell migration IMP 21325632
GO:0030837 negative regulation of actin filament polymerization IMP 23264465
genes like me logo Genes that share ontologies with MYADM: view

No data available for Pathways by source and SIGNOR curated interactions for MYADM Gene

Drugs & Compounds for MYADM Gene

No Compound Related Data Available

Transcripts for MYADM Gene

Unigene Clusters for MYADM Gene

Myeloid-associated differentiation marker:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYADM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for MYADM Gene

GeneLoc Exon Structure for
MYADM
ECgene alternative splicing isoforms for
MYADM

Expression for MYADM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYADM Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for MYADM Gene

This gene is overexpressed in Nasal epithelium (20.0) and Colon muscle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYADM Gene



Protein tissue co-expression partners for MYADM Gene

NURSA nuclear receptor signaling pathways regulating expression of MYADM Gene:

MYADM

SOURCE GeneReport for Unigene cluster for MYADM Gene:

Hs.380906

mRNA Expression by UniProt/SwissProt for MYADM Gene:

Q96S97-MYADM_HUMAN
Tissue specificity: Widely expressed. Not detected in thymus.

Evidence on tissue expression from TISSUES for MYADM Gene

  • Nervous system(4.7)
  • Bone marrow(4.5)
  • Thyroid gland(4.3)
  • Pancreas(3.5)
  • Blood(3.4)
  • Lung(3.1)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with MYADM: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYADM Gene

Orthologs for MYADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYADM 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
MYADM 34
  • 87.16 (n)
cow
(Bos Taurus)
Mammalia MYADM 34 35
  • 86.44 (n)
-- 35
  • 69 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myadm 34
  • 80.79 (n)
mouse
(Mus musculus)
Mammalia Myadm 34 16 35
  • 80.24 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MYADM 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myadm 34
  • 59.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29941 34
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-67a8.2 34
  • 59.37 (n)
MYADM (2 of 2) 35
  • 53 (a)
OneToMany
MYADM (1 of 2) 35
  • 49 (a)
OneToMany
-- 34
Species where no ortholog for MYADM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADM Gene

ENSEMBL:
Gene Tree for MYADM (if available)
TreeFam:
Gene Tree for MYADM (if available)

Paralogs for MYADM Gene

Paralogs for MYADM Gene

(2) SIMAP similar genes for MYADM Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MYADM Gene

genes like me logo Genes that share paralogs with MYADM: view

Variants for MYADM Gene

Sequence variations from dbSNP and Humsavar for MYADM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000084182 -- 53,870,495(+) CTCCT(-/ATAGG)AGATC intron-variant, upstream-variant-2KB
rs1000331964 -- 53,864,935(+) ACTCA(A/G)GAGTG intron-variant, upstream-variant-2KB
rs1000697174 -- 53,876,784(+) TCCTA(A/G)TTTGA downstream-variant-500B
rs1000858226 -- 53,871,751(+) GGGGT(A/G)CAGAG intron-variant
rs1001063307 -- 53,865,696(+) TCTAC(A/G)AGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MYADM Gene

Variant ID Type Subtype PubMed ID
esv24957 CNV loss 19812545
esv2663412 CNV deletion 23128226
esv2718812 CNV deletion 23290073
esv2718842 CNV deletion 23290073
esv2718843 CNV deletion 23290073
esv3644776 CNV loss 21293372
nsv1064558 CNV gain 25217958
nsv833876 CNV loss 17160897
nsv953610 CNV deletion 24416366

Variation tolerance for MYADM Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYADM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYADM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYADM Gene

Disorders for MYADM Gene

Relevant External Links for MYADM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYADM

No disorders were found for MYADM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADM Gene

Publications for MYADM Gene

  1. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all- trans retinoic acid. (PMID: 12075932) Cui W. … Zhao S. (Mol. Biol. Rep. 2001) 2 3 4 22 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for MYADM Gene

Sources for MYADM Gene

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