Aliases for MXRA8 Gene
External Ids for MXRA8 Gene
- HGNC: 7542
- Entrez Gene: 54587
- Ensembl: ENSG00000162576
- UniProtKB: Q9BRK3
Previous GeneCards Identifiers for MXRA8 Gene
- GC00U990744
- GC01U901165
- GC01M001278
- GC01M000561
Summaries for MXRA8 Gene
GeneCards Summary for MXRA8 Gene
MXRA8 (Matrix-Remodelling Associated 8) is a Protein Coding gene.
UniProtKB/Swiss-Prot for MXRA8 Gene
-
May play a role in the maturation and maintenance of blood-brain barrier.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXRA8 Gene
Genomics for MXRA8 Gene
Regulatory Elements for MXRA8 Gene
Enhancers for MXRA8 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around MXRA8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MXRA8 gene promoter:
Regulatory Element Products
Genomic Location for MXRA8 Gene
- Chromosome:
- 1
- Start:
- 1,352,689 bp from pter
- End:
- 1,363,541 bp from pter
- Size:
- 10,853 bases
- Orientation:
- Minus strand
Genomic View for MXRA8 Gene
Genes around MXRA8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.33 by Ensembl
- 1p36.33 by Entrez Gene
- 1p36.33 by HGNC
MXRA8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MXRA8 Gene
Proteins for MXRA8 Gene
-
Protein details for MXRA8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRK3-MXRA8_HUMAN
- Recommended name:
- Matrix-remodeling-associated protein 8
- Protein Accession:
- Q9BRK3
- B3KTR6
- B4DE34
- Q5TA39
- Q96KC3
Protein attributes for MXRA8 Gene
- Size:
- 442 amino acids
- Molecular mass:
- 49132 Da
- Quaternary structure:
- No Data Available
Protein Expression for MXRA8 Gene
Post-translational modifications for MXRA8 Gene
Other Protein References for MXRA8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MXRA8
- Search GeneTex for Antibodies for MXRA8
-
Santa Cruz Biotechnology (SCBT) Antibodies for MXRA8
Protein Products
- R&D Systems Proteins and Enzymes for MXRA8 (MXRA8/DICAM)
-
OriGene Purified Proteins for MXRA8
- Search Origene for MassSpec and Protein Over-expression Lysates for MXRA8
- Origene Custom Protein Services for MXRA8
- Novus Biologicals proteins for MXRA8
- antibodies-online Proteins for MXRA8: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MXRA8
Assay Products
- antibodies-online Kits for MXRA8: See all 1
No data available for DME Specific Peptides for MXRA8 Gene
Domains & Families for MXRA8 Gene
Gene Families for MXRA8 Gene
Protein Domains for MXRA8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MXRA8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BRK3- Domain:
-
- Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Function for MXRA8 Gene
Molecular function for MXRA8 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the maturation and maintenance of blood-brain barrier.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for MXRA8 Gene
- MGI mutant phenotypes for MXRA8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MXRA8:
Animal Model Products
-
Taconic Biosciences Mouse Models for MXRA8
-
ViGene Biosciences lentiviral particle packaged cDNA for MXRA8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MXRA8 gene
- Search ViGene Biosciences for MXRA8
CRISPR Products
-
OriGene CRISPR knockouts for MXRA8
-
Santa Cruz Biotechnology (SCBT) CRISPR for MXRA8
- GenScript: Design CRISPR guide RNA sequences for MXRA8
miRNA for MXRA8 Gene
- miRTarBase miRNAs that target MXRA8
miRNA Products
- Search ViGene Biosciences for MXRA8
Clone Products
- OriGene clones in human for MXRA8
- OriGene ORF clones in human,mouse,rat for MXRA8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MXRA8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for MXRA8 (MXRA8/DICAM)
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MXRA8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MXRA8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MXRA8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MXRA8 Gene
Localization for MXRA8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MXRA8 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| plasma membrane | 2 |
| endoplasmic reticulum | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for MXRA8 Gene
More details on SuperPathways for MXRA8
No Data Available
Interacting Proteins for MXRA8 Gene
No data available for Pathways by source and SIGNOR curated interactions for MXRA8 Gene
Transcripts for MXRA8 Gene
mRNA/cDNA for MXRA8 Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MXRA8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MXRA8
-
Santa Cruz Biotechnology (SCBT) CRISPR for MXRA8
- GenScript: Design CRISPR guide RNA sequences for MXRA8
miRNA Products
- Search ViGene Biosciences for MXRA8
Clone Products
- OriGene clones in human for MXRA8
- OriGene ORF clones in human,mouse,rat for MXRA8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MXRA8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for MXRA8 (MXRA8/DICAM)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: |
Expression for MXRA8 Gene
This gene is overexpressed in Urine (55.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MXRA8 Gene
SOURCE GeneReport for Unigene cluster for MXRA8 Gene Hs.515687
Primer Products
-
OriGene qPCR primer pairs for MXRA8
-
OriGene qPCR primer pairs and template standards for MXRA8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MXRA8 Gene
Orthologs for MXRA8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MXRA8 35 |
|
||
| MXRA8 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | MXRA8 35 |
|
||
| MXRA8 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mxra8 35 |
|
||
| Mxra8 16 |
|
||||
| Mxra8 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Mxra8 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MXRA8 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MXRA8 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MXRA8 35 |
|
||
| MXRA8 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | MXRA8 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mxra8 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mxra8a 35 |
|
||
| mxra8a 36 |
|
OneToMany | |||
| mxra8b 36 |
|
OneToMany |
- Species with no ortholog for MXRA8:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MXRA8 Gene
No data available for Paralogs for MXRA8 Gene
Variants for MXRA8 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs150058708 | - | 1,354,066(+) | CTGGT(C/T)CCCTG | reference, missense | |
| rs13249 | -- | 1,352,965(-) | ACCCC(C/T)TGCCC | utr-variant-3-prime | |
| rs307382 | -- | 1,354,274(-) | ACCTG(C/T)GGAAG | intron-variant | |
| rs1046676 | -- | 1,352,956(+) | GCAGA(A/G)AAAGG | utr-variant-3-prime | |
| rs1046678 | -- | 1,352,954(+) | GGGCA(A/G)AGAAA | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv10161 | CNV | Gain+Loss | 18304495 |
| dgv2n67 | CNV | Gain | 20364138 |
| dgv10n71 | CNV | Loss | 21882294 |
| dgv12n71 | CNV | Loss | 21882294 |
| nsv470680 | CNV | Loss | 18288195 |
| dgv17n71 | CNV | Loss | 21882294 |
| dgv19n71 | CNV | Loss | 21882294 |
| dgv20n71 | CNV | Loss | 21882294 |
| nsv870527 | CNV | Gain | 21882294 |
| nsv482937 | CNV | Loss | 15286789 |
| dgv22n71 | CNV | Loss | 21882294 |
| dgv25n71 | CNV | Loss | 21882294 |
| nsv870639 | CNV | Loss | 21882294 |
| nsv871666 | CNV | Gain+Loss | 21882294 |
| dgv28n71 | CNV | Gain | 21882294 |
| dgv8e1 | CNV | Complex | 17122850 |
| dgv29n71 | CNV | Loss | 21882294 |
| dgv30n71 | CNV | Gain | 21882294 |
| dgv31n71 | CNV | Gain | 21882294 |
| dgv32n71 | CNV | Gain+Loss | 21882294 |
| dgv33n71 | CNV | Loss | 21882294 |
| dgv34n71 | CNV | Loss | 21882294 |
| nsv870491 | CNV | Loss | 21882294 |
| dgv38n71 | CNV | Loss | 21882294 |
| dgv39n71 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.88;
59.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MXRA8 Gene
- Human Gene Mutation Database (HGMD)
- MXRA8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXRA8 Gene
Disorders for MXRA8 Gene
Relevant External Links for MXRA8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MXRA8
No disorders were found for MXRA8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXRA8 Gene
Publications for MXRA8 Gene
- Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. (PMID: 14603461) Yonezawa T. … Ninomiya Y. (Glia 2003) 2 3 4 67
- Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
- DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling. (PMID: 23386276) Han S.W. … Choi J.Y. (Cardiovasc. Res. 2013) 3
- In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
- The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz H.J. … Yaspo M.L. (J. Biol. Chem. 2011) 3
Products for MXRA8 Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for MXRA8 (MXRA8/DICAM)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for MXRA8 (MXRA8/DICAM)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MXRA8
- Search Origene for MassSpec and Protein Over-expression Lysates for MXRA8
- Origene Custom Protein Services for MXRA8
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for MXRA8
- Browse OriGene Inhibitory RNA Products For MXRA8
- OriGene qPCR primer pairs for MXRA8
- OriGene qPCR primer pairs and template standards for MXRA8
- OriGene CRISPR knockouts for MXRA8
- OriGene clones in human for MXRA8
- OriGene ORF clones in human,mouse,rat for MXRA8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MXRA8
- GenScript Custom Assay Services for MXRA8
- GenScript Custom overexpressing Cell Line Services for MXRA8
- GenScript: Design CRISPR guide RNA sequences for MXRA8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MXRA8
- Novus Biologicals Antibodies for MXRA8
- Novus Biologicals proteins for MXRA8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for MXRA8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search antibodies-online for antibodies
- antibodies-online Kits for MXRA8: See all 1
- antibodies-online Proteins for MXRA8: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for MXRA8
- Search GeneTex for Proteins for MXRA8
- ViGene Biosciences adenoviral particle packaged cDNA for MXRA8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MXRA8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MXRA8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MXRA8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MXRA8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MXRA8 gene
- Search ViGene Biosciences for MXRA8
- Search ViGene Biosciences for MXRA8
- Santa Cruz Biotechnology (SCBT) Antibodies for MXRA8
- Search Santa Cruz Biotechnology (SCBT) for MXRA8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MXRA8
Sources for MXRA8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon