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MXRA8 Gene

protein-coding   GIFtS: 46
GCID: GC01M001278

Matrix-Remodelling Associated 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Matrix-Remodelling Associated 81 2
limitrin1 2
Matrix-Remodeling-Associated Protein 82
Limitrin3

External Ids:    HGNC: 75421   Entrez Gene: 545872   Ensembl: ENSG000001625767   UniProtKB: Q9BRK33   
ORGUL members:         

Export aliases for MXRA8 gene to outside databases

Previous GC identifers: GC00U990744 GC01U901165 GC01M000561


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MXRA8 Gene:
MXRA8 (matrix-remodelling associated 8) is a protein-coding gene.

UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3
Function: May play a role in the maturation and maintenance of blood-brain barrier (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MXRA8 gene promoter:
         PPAR-gamma1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMXRA8 promoter sequence
   Search Chromatin IP Primers for MXRA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MXRA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

MXRA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXRA8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001278:  view genomic region     (about GC identifiers)

Start:
1,288,069 bp from pter      End:
1,297,157 bp from pter
Size:
9,089 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3 (See protein sequence)
Recommended Name: Matrix-remodeling-associated protein 8 precursor  
Size: 442 amino acids; 49132 Da
Secondary accessions: Q5TA39 Q96KC3
Alternative splicing: 2 isoforms:  Q9BRK3-1   Q9BRK3-2   

Explore the universe of human proteins at neXtProt for MXRA8: NX_Q9BRK3

Explore proteomics data for MXRA8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn119, Asn306
  • Modification sites at PhosphoSitePlus

  • See MXRA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001269511.1  NP_001269512.1  NP_001269513.1  NP_001269514.1  NP_115724.1  

    ENSEMBL proteins: 
     ENSP00000307887   ENSP00000399229   ENSP00000436135   ENSP00000344998  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9BRK3

    ProtoNet protein and cluster: Q9BRK3

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with MXRA8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MXRA8_HUMAN, Q9BRK3
    Function: May play a role in the maturation and maintenance of blood-brain barrier (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MXRA8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mxra8):
     normal 

    Find genes that share phenotypes with MXRA8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MXRA8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MXRA8
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    miRNA
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    miRTarBase miRNAs that target MXRA8:
    hsa-mir-335-5p (MIRT018682)

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    6 qRT-PCR Assays for microRNAs that regulate MXRA8:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-548c-3p hsa-miR-3157-5p hsa-miR-766 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMXRA8 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MXRA8_HUMAN, Q9BRK3: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface ISS14603461
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MXRA8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MXRA8
    Interactions:

        Search GeneGlobe Interaction Network for MXRA8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MXRA8 (Q9BRK33 ENSP000003078874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    OPTCENSP000003561914STRING: ENSP00000356191
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060857establishment of glial blood-brain barrier ISS14603461

    Find genes that share ontologies with MXRA8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MXRA8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MXRA8 gene (5 alternative transcripts): 
    NM_001282582.1  NM_001282583.1  NM_001282584.1  NM_001282585.1  NM_032348.3  

    Unigene Cluster for MXRA8:

    Matrix-remodelling associated 8
    Hs.515687  [show with all ESTs]
    Unigene Representative Sequence: AK095966
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474033 ENST00000309212(uc001aew.3 uc001aey.4 uc001aez.3)
    ENST00000445648(uc001aex.4) ENST00000477278(uc001afa.3) ENST00000473097
    ENST00000478517 ENST00000476718 ENST00000464351 ENST00000460473 ENST00000342753

    miRNA
    Products:
         
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    6 qRT-PCR Assays for microRNAs that regulate MXRA8:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-548c-3p hsa-miR-3157-5p hsa-miR-766 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMXRA8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MXRA8
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MXRA8 (NM_032348)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXRA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA8
    Primer
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    OriGene qPCR primer pairs and template standards for MXRA8
    OriGene qSTAR qPCR primer pairs in human, mouse for MXRA8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MXRA8
      QuantiTect SYBR Green Assays in human, mouse, rat MXRA8
      QuantiFast Probe-based Assays in human, mouse, rat MXRA8

    Additional mRNA sequence: 

    AB052096.1 AK027269.1 AK095966.1 AK225028.1 AK293442.1 AK304615.1 AK315510.1 AL050202.1 
    AY358391.1 BC006213.2 BC017312.2 

    14 DOTS entries:

    DT.101983679  DT.95223113  DT.444857  DT.121333040  DT.97846475  DT.100786102  DT.100060876  DT.121333029 
    DT.121333042  DT.92332531  DT.95284120  DT.121333054  DT.95268902  DT.95351662 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MXRA8    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:                                                                    -     -               
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MXRA8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MXRA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGACTCCA
    MXRA8 Expression
    About this image


    MXRA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Semilunar Valves
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Rib
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MXRA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MXRA8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515687
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MXRA8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mxra81 , 5 matrix-remodelling associated 81, 5 78.08(n)1
    78.46(a)1
      4 (87.58 cM)5
    747611  NM_024263.41  NP_077225.41 
     1558396805 
    chicken
    (Gallus gallus)
    Aves MXRA81 matrix-remodelling associated 8 64.21(n)
    61.06(a)
      395347  NM_204636.2  NP_989967.1 
    lizard
    (Anolis carolinensis)
    Reptilia MXRA86
    matrix-remodelling associated 8
    56(a)
    1 ↔ 1
    GL343701.1(1897-23970)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mxra81 matrix-remodelling associated 8 57.64(n)
    53.7(a)
      100101754  NM_001122725.1  NP_001116197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mxra8a1 matrix-remodelling associated 8a 56.5(n)
    51.42(a)
      562784  NM_001080582.1  NP_001074051.1 


    ENSEMBL Gene Tree for MXRA8 (if available)
    TreeFam Gene Tree for MXRA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MXRA8 (see all 254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817121231,2
    --1287588(+) CTGCAC/GCCAAC 1 -- int10--------
    rs1406884251,2
    --1287635(+) GATCCA/GTGCTG 1 -- int10--------
    rs1456788791,2
    C--1287732(+) GACCCA/GCATCC 1 -- int10--------
    rs1860763201,2
    --1287748(+) CTCCCA/GCTCCT 1 -- int10--------
    rs1383376141,2
    C--1287755(+) TCCTCA/GTCCCT 1 -- int10--------
    rs1904508331,2
    --1287896(+) ACTAGC/GTCAAA 1 -- int10--------
    rs37661851,2
    C--1287922(-) GGAGTT/CGGTGT 1 -- int19Minor allele frequency- C:0.20EA NA WA CSA 1508
    rs1432405911,2
    --1287964(+) AGGAAC/TGGGAT 1 -- int10--------
    rs1480498831,2
    C--1287973(+) ATGATA/GTCAGG 1 -- int10--------
    rs354810251,2
    C,F--1288042(-) AAACTC/TCGTCT 1 -- int12Minor allele frequency- T:0.50NA CSA 6

    HapMap Linkage Disequilibrium report for MXRA8 (1288069 - 1297157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MXRA8 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv17n71CNV Loss21882294
    nsv470680CNV Loss18288195
    nsv870639CNV Loss21882294
    dgv29n71CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv39n71CNV Loss21882294
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv19n71CNV Loss21882294
    nsv870491CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MXRA8
    DNA2.0 Custom Variant and Variant Library Synthesis for MXRA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MXRA8 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MXRA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. (PubMed id 14603461)1, 2, 3 Yonezawa T.... Ninomiya Y. (Glia 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling. (PubMed id 23386276)1 Han S.W....Choi J.Y. (Cardiovasc. Res. 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
    6. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54587 HGNC: 7542 Ensembl:ENSG00000162576 euGenes: HUgn54587 ECgene: MXRA8
    H-InvDB: MXRA8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MXRA8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MXRA8 gene:
    Search GeneIP for patents involving MXRA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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