Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MXRA8 Gene

protein-coding GIFtS: 40
GCID: GC01M001278

Matrix-Remodelling Associated 8

Search for MXRA8
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Matrix-Remodelling Associated 8¹ ²
limitrin¹ ²
Matrix-Remodeling-Associated Protein 8²
Limitrin³

External Ids:	HGNC: 7542¹	Entrez Gene: 54587²	Ensembl: ENSG00000162576⁷	UniProtKB: Q9BRK3³

Export aliases for MXRA8 gene to outside databases

Previous GC identifers: GC00U990744 GC01U901165 GC01M000561

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MXRA8 Gene:

MXRA8 (matrix-remodelling associated 8) is a protein-coding gene.

UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3

Function: May play a role in the maturation and maintenance of blood-brain barrier (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004350.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MXRA8 gene promoter:
PPAR-gamma1 PPAR-gamma2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MXRA8 promoter sequence

Search SABiosciences Chromatin IP Primers for MXRA8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXRA8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33

MXRA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXRA8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001278: view genomic region (about GC identifiers)

Start:	1,288,069 bp from pter	End:	1,297,157 bp from pter
Size:	9,089 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3 (See protein sequence)

Recommended Name: Matrix-remodeling-associated protein 8 precursor

Size: 442 amino acids; 49132 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q5TA39 Q96KC3

Alternative splicing: 2 isoforms: Q9BRK3-1 Q9BRK3-2

Explore the universe of human proteins at neXtProt for MXRA8: NX_Q9BRK3

Explore proteomics data for MXRA8 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BRK3

MXRA8 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (5 alternative transcripts):

NP_001269511.1 NP_001269512.1 NP_001269513.1 NP_001269514.1 NP_115724.1

ENSEMBL proteins:

ENSP00000307887 ENSP00000399229 ENSP00000436135 ENSP00000344998

Human Recombinant Protein Products for MXRA8:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MXRA8 OriGene Protein Over-expression Lysate for MXRA8 OriGene MassSpec for MXRA8 OriGene Custom Protein Services for MXRA8
	GenScript Custom Purified and Recombinant Proteins Services for MXRA8
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MXRA8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

MXRA8 for ontologies About GeneDecksing

MXRA8 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MXRA8
	GenScript Custom Superior Antibodies Services for MXRA8
	Search for Antibodies for MXRA8 at Abcam
	Cloud-Clone Corp. Antibodies for MXRA8
	Search ThermoFisher Antibodies for MXRA8
	Search LSBio for Antibodies for MXRA8

Assay Products for MXRA8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MXRA8
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MXRA8
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MXRA8 Cloud-Clone Corp. CLIAs for MXRA8

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q9BRK3

ProtoNet protein and cluster: Q9BRK3

1 Blocks protein domain: IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: MXRA8_HUMAN, Q9BRK3

Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains

MXRA8 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MXRA8_HUMAN, Q9BRK3

Function: May play a role in the maturation and maintenance of blood-brain barrier (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

MXRA8 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mxra8):

normal

MXRA8 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for MXRA8

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MXRA8

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MXRA8

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MXRA8

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MXRA8
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate MXRA8:
		hsa-miR-125a-5p hsa-miR-125b hsa-miR-548c-3p hsa-miR-3157-5p hsa-miR-766 hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MXRA8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MXRA8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXRA8

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MXRA8
			Sirion Biotech Customized adenovirus for overexpression of MXRA8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for MXRA8 (see all 8) OriGene ORF clones in mouse, rat for MXRA8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MXRA8 (NM_032348)
		Sino Biological Human cDNA Clone for MXRA8
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXRA8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA8
		Sirion Biotech Customized lentivirus for stable overexpression of MXRA8 Customized lentivirus expression plasmids for stable overexpression of MXRA8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MXRA8
		Search LifeMap BioReagents cell lines for MXRA8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXRA8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MXRA8

2 Interacting proteins for MXRA8 (Q9BRK3³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC2A4	P14672³	I2D: score=1
WNK1	Q9H4A3³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MXRA8

Search CenterWatch for drugs/clinical trials and news about MXRA8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MXRA8 gene (5 alternative transcripts):

NM_001282582.1 NM_001282583.1 NM_001282584.1 NM_001282585.1 NM_032348.3

Unigene Cluster for MXRA8:

Matrix-remodelling associated 8

Hs.515687 [show with all ESTs]

Unigene Representative Sequence: AK095966

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000474033 ENST00000309212(uc001aew.3 uc001aey.4 uc001aez.3)

ENST00000445648(uc001aex.4) ENST00000477278(uc001afa.3) ENST00000473097

ENST00000478517 ENST00000476718 ENST00000464351 ENST00000460473 ENST00000342753

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MXRA8
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate MXRA8:
		hsa-miR-125a-5p hsa-miR-125b hsa-miR-548c-3p hsa-miR-3157-5p hsa-miR-766 hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MXRA8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MXRA8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXRA8

Clone Products:		OriGene clones in human, mouse for MXRA8 (see all 8) OriGene ORF clones in mouse, rat for MXRA8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MXRA8 (NM_032348)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXRA8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA8
		Sirion Biotech Customized lentivirus for stable overexpression of MXRA8 Customized lentivirus expression plasmids for stable overexpression of MXRA8

Primer Products:		OriGene qPCR primer pairs and template standards for MXRA8 OriGene qSTAR qPCR primer pairs in human, mouse for MXRA8
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MXRA8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXRA8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXRA8

Additional mRNA sequence:

AB052096.1 AK027269.1 AK095966.1 AK225028.1 AK293442.1 AK304615.1 AK315510.1 AL050202.1

AY358391.1 BC006213.2 BC017312.2

14 DOTS entries:

DT.101983679 DT.95223113 DT.444857 DT.121333040 DT.97846475 DT.100786102 DT.100060876 DT.121333029

DT.121333042 DT.92332531 DT.95284120 DT.121333054 DT.95268902 DT.95351662

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MXRA8 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b
SP1:
SP2:
SP3:																							-		-
SP4:
SP5:

ECgene alternative splicing isoforms for MXRA8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MXRA8 expression in normal human tissues (normalized intensities) MXRA8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGGGACTCCA

About this image

MXRA8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/32 selected tissues (see all 32) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Epithelium (Uncategorized) fully expand to see all 4 entries
vagina ; squamous epithelial cells

Testis (Reproductive System) fully expand to see all 3 entries
Leydig Cells Testis Interstitium
testis ; cells in seminiferus ducts

Heart (Cardiovascular System) fully expand to see all 3 entries
Semilunar Valves
heart/valve/pulmonary valve

Colon (Gastrointestinal Tract) fully expand to see all 3 entries
colon ; peripheral nerve/ganglion

See MXRA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MXRA8

SOURCE GeneReport for Unigene cluster: Hs.515687

SABiosciences Custom PCR Arrays for MXRA8

Primer Products:		OriGene qPCR primer pairs and template standards for MXRA8 OriGene qSTAR qPCR primer pairs in human, mouse for MXRA8
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MXRA8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXRA8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXRA8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXRA8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MXRA8 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mxra8^{1 , 5}	matrix-remodelling associated 8^{1, 5}	78.08(n)¹ 78.46(a)¹		4 (87.58 cM)⁵ 74761¹ NM_024263.4¹ NP_077225.4¹ 155839680⁵
chicken (Gallus gallus)	Aves	MXRA8¹	matrix-remodelling associated 8	64.34(n) 61.4(a)		395347 NM_204636.1 NP_989967.1
lizard (Anolis carolinensis)	Reptilia	MXRA8⁶	Uncharacterized protein	57(a)	1 ↔ 1	GL343701.1(1897-23970)
zebrafish (Danio rerio)	Actinopterygii	mxra8a¹	matrix-remodelling associated 8a	54.9(n) 49.29(a)		562784 NM_001080582.1 NP_001074051.1

ENSEMBL Gene Tree for MXRA8 (if available)
TreeFam Gene Tree for MXRA8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181712123^1,2		--	1287588(+)	`CTGCAC/GCCAAC`	1	--	int¹		0	--	--	--	--
rs140688425^1,2		--	1287635(+)	`GATCCA/GTGCTG`	1	--	int¹		0	--	--	--	--
rs145678879^1,2	C	--	1287732(+)	`GACCCA/GCATCC`	1	--	int¹		0	--	--	--	--
rs186076320^1,2		--	1287748(+)	`CTCCCA/GCTCCT`	1	--	int¹		0	--	--	--	--
rs138337614^1,2	C	--	1287755(+)	`TCCTCA/GTCCCT`	1	--	int¹		0	--	--	--	--
rs190450833^1,2		--	1287896(+)	`ACTAGC/GTCAAA`	1	--	int¹		0	--	--	--	--
rs3766185^1,2	C	--	1287922(-)	`GGAGTT/CGGTGT`	1	--	int¹		9		EA NA WA CSA	1508
rs143240591^1,2		--	1287964(+)	`AGGAAC/TGGGAT`	1	--	int¹		0	--	--	--	--
rs148049883^1,2	C	--	1287973(+)	`ATGATA/GTCAGG`	1	--	int¹		0	--	--	--	--
rs35481025^1,2	C,F	--	1288042(-)	`AAACTC/TCGTCT`	1	--	int¹		2		NA CSA	6

HapMap Linkage Disequilibrium report for MXRA8 (1288069 - 1297157 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/25 variations for MXRA8 (see all 25): About this table

Variant ID	Type	Subtype	PubMed ID
dgv17n71	CNV	Loss	21882294
nsv470680	CNV	Loss	18288195
nsv870639	CNV	Loss	21882294
dgv29n71	CNV	Loss	21882294
nsv482937	CNV	Loss	15286789
dgv39n71	CNV	Loss	21882294
dgv12n71	CNV	Loss	21882294
dgv25n71	CNV	Loss	21882294
dgv19n71	CNV	Loss	21882294
nsv870491	CNV	Loss	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MXRA8

DNA2.0 Custom Variant and Variant Library Synthesis for MXRA8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MXRA8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MXRA8)

Utopia: connect your pdf to the dynamic
world of online information

Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. (PubMed id 14603461)^{1, 2, 3} Yonezawa T.... Ninomiya Y. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling. (PubMed id 23386276)¹ Han S.W....Choi J.Y. (2013)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)
The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)¹ Warnatz H.J....Yaspo M.L. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)¹ Clark H.F.... Gray A.M. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54587	HGNC: 7542	Ensembl:ENSG00000162576	euGenes: HUgn54587	ECgene: MXRA8
H-InvDB: MXRA8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MXRA8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MXRA8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MXRA8 gene:
Search GeneIP for patents involving MXRA8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MXRA8
	OriGene qPCR primer pairs and template standards for MXRA8		OriGene Protein Over-expression Lysate for MXRA8
	OriGene MassSpec something-or-other for MXRA8		OriGene clones in human, mouse for MXRA8
	OriGene qSTAR qPCR primer pairs in human, mouse for MXRA8		OriGene Purified Protein for MXRA8
	OriGene ORF clones in mouse, rat for MXRA8		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MXRA8		OriGene Custom Protein Services for MXRA8

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MXRA8
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MXRA8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXRA8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXRA8
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXRA8
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXRA8

	GenScript Custom Purified and Recombinant Proteins Services for MXRA8		GenScript cDNA clones with any tag delivered in your preferred vector for MXRA8
	GenScript Custom Assay Services for MXRA8		GenScript Custom Superior Antibodies Services for MXRA8
	GenScript Custom overexpressing Cell Line Services for MXRA8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MXRA8 promoter
	Search Chromatin IP Primers for MXRA8
	RT² qPCR Primer Assay in human, mouse, rat MXRA8
	Search GNC Networks for MXRA8
	SABiosciences Custom PCR Arrays for MXRA8

Search Tocris compounds for MXRA8

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	cDNA Clones for MXRA8
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Search for Antibodies for MXRA8 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for MXRA8
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MXRA8
	Antibodies for MXRA8
	ELISAs for MXRA8
	CLIAs for MXRA8

Search LifeMap BioReagents cell lines for MXRA8

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXRA8

	SwitchGear 3'UTR luciferase reporter plasmids for MXRA8
	SwitchGear Promoter luciferase reporter plasmids for MXRA8

Search ThermoFisher Antibodies for MXRA8

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA8

	inGenious Targeting Laboratory - Custom generated mouse model solutions for MXRA8
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MXRA8

Customized:

	lentivirus for stable overexpression of MXRA8
	lentivirus expression plasmids for stable overexpression of MXRA8
	adenovirus for overexpression of MXRA8

Search LSBio for Antibodies for MXRA8

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MXRA8 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MXRA8 Gene

Matrix-Remodelling Associated 8

Aliases
for MXRA8 gene

Summaries
for MXRA8 gene

Genomic Views
for MXRA8 gene

Proteins
for MXRA8 gene

Protein Domains /
Families
for MXRA8 gene

Function
for MXRA8 gene

Pathways & Interactions
for MXRA8 gene

Drugs & Compounds
for MXRA8 gene

Transcripts
for MXRA8 gene

Expression
for MXRA8 gene

Orthologs
for MXRA8 gene

Paralogs
for MXRA8 gene

Genomic Variants
for MXRA8 gene

Disorders / Diseases
for MXRA8 gene

Publications
for MXRA8 gene

External Searches for MXRA8 gene

Genome Databases showing MXRA8 gene

Other Databases showing MXRA8 gene

Specialized Databases showing MXRA8 gene

Intellectual Property
for MXRA8 gene

Products
for MXRA8 gene

View Random Gene

Advanced Search

Export list of displayed genes

MXRA8 Gene

Matrix-Remodelling Associated 8

Aliasesfor MXRA8 gene

Summariesfor MXRA8 gene

Genomic Viewsfor MXRA8 gene

Proteinsfor MXRA8 gene

Protein Domains /Familiesfor MXRA8 gene

Functionfor MXRA8 gene

Pathways & Interactionsfor MXRA8 gene

Drugs & Compoundsfor MXRA8 gene

Transcriptsfor MXRA8 gene

Expression for MXRA8 gene

Orthologsfor MXRA8 gene

Paralogsfor MXRA8 gene

Genomic Variantsfor MXRA8 gene

Disorders / Diseasesfor MXRA8 gene

Publicationsfor MXRA8 gene

External Searches for MXRA8 gene

Genome Databases showing MXRA8 gene

Other Databases showing MXRA8 gene

Specialized Databases showing MXRA8 gene

Intellectual Propertyfor MXRA8 gene

Productsfor MXRA8 gene

View Random Gene

Aliases
for MXRA8 gene

Summaries
for MXRA8 gene

Genomic Views
for MXRA8 gene

Proteins
for MXRA8 gene

Protein Domains /
Families
for MXRA8 gene

Function
for MXRA8 gene

Pathways & Interactions
for MXRA8 gene

Drugs & Compounds
for MXRA8 gene

Transcripts
for MXRA8 gene

Expression
for MXRA8 gene

Orthologs
for MXRA8 gene

Paralogs
for MXRA8 gene

Genomic Variants
for MXRA8 gene

Disorders / Diseases
for MXRA8 gene

Publications
for MXRA8 gene

Intellectual Property
for MXRA8 gene

Products
for MXRA8 gene