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Aliases for MXRA8 Gene

Aliases for MXRA8 Gene

  • Matrix-Remodelling Associated 8 2 3
  • Limitrin 2 3 4

External Ids for MXRA8 Gene

Previous GeneCards Identifiers for MXRA8 Gene

  • GC00U990744
  • GC01U901165
  • GC01M001278
  • GC01M000561

Summaries for MXRA8 Gene

GeneCards Summary for MXRA8 Gene

MXRA8 (Matrix-Remodelling Associated 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MXRA8 Gene

  • May play a role in the maturation and maintenance of blood-brain barrier.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXRA8 Gene

Genomics for MXRA8 Gene

Regulatory Elements for MXRA8 Gene

Genomic Location for MXRA8 Gene

Chromosome:
1
Start:
1,352,689 bp from pter
End:
1,363,541 bp from pter
Size:
10,853 bases
Orientation:
Minus strand

Genomic View for MXRA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MXRA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXRA8 Gene

Proteins for MXRA8 Gene

  • Protein details for MXRA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRK3-MXRA8_HUMAN
    Recommended name:
    Matrix-remodeling-associated protein 8
    Protein Accession:
    Q9BRK3
    Secondary Accessions:
    • B3KTR6
    • B4DE34
    • Q5TA39
    • Q96KC3

    Protein attributes for MXRA8 Gene

    Size:
    442 amino acids
    Molecular mass:
    49132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MXRA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MXRA8 Gene

Proteomics data for MXRA8 Gene at MOPED

Post-translational modifications for MXRA8 Gene

  • Glycosylation at Asn 119 and Asn 306
  • Modification sites at PhosphoSitePlus

Other Protein References for MXRA8 Gene

No data available for DME Specific Peptides for MXRA8 Gene

Domains & Families for MXRA8 Gene

Gene Families for MXRA8 Gene

Protein Domains for MXRA8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRK3

UniProtKB/Swiss-Prot:

MXRA8_HUMAN :
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MXRA8: view

Function for MXRA8 Gene

Molecular function for MXRA8 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the maturation and maintenance of blood-brain barrier.

Gene Ontology (GO) - Molecular Function for MXRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MXRA8: view

Phenotypes for MXRA8 Gene

MGI mutant phenotypes for MXRA8:
inferred from 1 alleles
GenomeRNAi human phenotypes for MXRA8:
genes like me logo Genes that share phenotypes with MXRA8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MXRA8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MXRA8 Gene

Localization for MXRA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXRA8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MXRA8 Gene COMPARTMENTS Subcellular localization image for MXRA8 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for MXRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface ISS 14603461
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MXRA8: view

Pathways & Interactions for MXRA8 Gene

SuperPathways for MXRA8 Gene

No Data Available

Interacting Proteins for MXRA8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307887%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000356191%0d%0a
Selected Interacting proteins: Q9BRK3-MXRA8_HUMAN ENSP00000307887 for MXRA8 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MXRA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060857 establishment of glial blood-brain barrier ISS 14603461
genes like me logo Genes that share ontologies with MXRA8: view

No data available for Pathways by source and SIGNOR curated interactions for MXRA8 Gene

Drugs & Compounds for MXRA8 Gene

No Compound Related Data Available

Transcripts for MXRA8 Gene

mRNA/cDNA for MXRA8 Gene

(5) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MXRA8 Gene

Matrix-remodelling associated 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MXRA8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MXRA8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1:
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for MXRA8 Gene

GeneLoc Exon Structure for
MXRA8
ECgene alternative splicing isoforms for
MXRA8

Expression for MXRA8 Gene

mRNA expression in normal human tissues for MXRA8 Gene

Protein differential expression in normal tissues from HIPED for MXRA8 Gene

This gene is overexpressed in Urine (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MXRA8 Gene



SOURCE GeneReport for Unigene cluster for MXRA8 Gene Hs.515687

genes like me logo Genes that share expression patterns with MXRA8: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MXRA8 Gene

Orthologs for MXRA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MXRA8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MXRA8 35
  • 84.74 (n)
  • 84.27 (a)
MXRA8 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MXRA8 35
  • 84.99 (n)
  • 83.26 (a)
MXRA8 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mxra8 35
  • 78.08 (n)
  • 78.46 (a)
Mxra8 16
Mxra8 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mxra8 35
  • 77.17 (n)
  • 79.27 (a)
oppossum
(Monodelphis domestica)
Mammalia MXRA8 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MXRA8 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MXRA8 35
  • 64.21 (n)
  • 61.06 (a)
MXRA8 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXRA8 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mxra8 35
  • 57.64 (n)
  • 53.7 (a)
zebrafish
(Danio rerio)
Actinopterygii mxra8a 35
  • 56.5 (n)
  • 51.42 (a)
mxra8a 36
  • 47 (a)
OneToMany
mxra8b 36
  • 42 (a)
OneToMany
Species with no ortholog for MXRA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MXRA8 Gene

ENSEMBL:
Gene Tree for MXRA8 (if available)
TreeFam:
Gene Tree for MXRA8 (if available)

Paralogs for MXRA8 Gene

No data available for Paralogs for MXRA8 Gene

Variants for MXRA8 Gene

Sequence variations from dbSNP and Humsavar for MXRA8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13249 -- 1,352,965(-) ACCCC(C/T)TGCCC utr-variant-3-prime
rs307382 -- 1,354,274(-) ACCTG(C/T)GGAAG intron-variant
rs1046676 -- 1,352,956(+) GCAGA(A/G)AAAGG utr-variant-3-prime
rs1046678 -- 1,352,954(+) GGGCA(A/G)AGAAA utr-variant-3-prime
rs1801570 -- 1,352,879(-) CCTGA(A/C/T)ACCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MXRA8 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
dgv39n71 CNV Loss 21882294

Variation tolerance for MXRA8 Gene

Residual Variation Intolerance Score: 36.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MXRA8 Gene

HapMap Linkage Disequilibrium report
MXRA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXRA8 Gene

Disorders for MXRA8 Gene

Relevant External Links for MXRA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MXRA8
genes like me logo Genes that share disorders with MXRA8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXRA8 Gene

Publications for MXRA8 Gene

  1. Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. (PMID: 14603461) Yonezawa T. … Ninomiya Y. (Glia 2003) 2 67
  2. A single kinase generates the majority of the secreted phosphoproteome. (PMID: 26091039) Tagliabracci V.S. … Dixon J.E. (Cell 2015) 67
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  4. DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling. (PMID: 23386276) Han S.W. … Choi J.Y. (Cardiovasc. Res. 2013) 67
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67

Products for MXRA8 Gene

Sources for MXRA8 Gene

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