MXRA8 Gene

Aliases
for MXRA8 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC00U990744 GC01U901165 GC01M000561

Summaries
for MXRA8 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MXRA8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_032977.10  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: MXRA8 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MXRA8

MXRA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001278:  view genomic region     (about GC identifiers)

Proteins
for MXRA8 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MXRA8: NX_Q9BRK3

Explore proteomics data for MXRA8 at MOPED

Post-translational modifications: 

MXRA8 Human Recombinant Protein Products:

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	antibodies-online proteins for MXRA8 (4 products)
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MXRA8 Assay Products:

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	antibodies-online kits for MXRA8 (10 products)

Domains /
Families
for MXRA8 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BRK3

Find genes that share domains with MXRA8           About GenesLikeMe

Function
for MXRA8 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Mxra8)

genOway: Develop your customized and physiologically relevant rodent model for MXRA8

miRNA Products:		miRTarBase miRNAs that target MXRA8: hsa-mir-335-5p (MIRT018682)
		Block miRNA regulation of human, mouse, rat MXRA8 using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate MXRA8:
		hsa-miR-125a-5p hsa-miR-125b hsa-miR-548c-3p hsa-miR-3157-5p hsa-miR-766 hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: MXRA8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MXRA8
		Predesigned siRNA for gene silencing in human, mouse, rat MXRA8

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MXRA8

Clone Products:		OriGene clones in human, mouse for MXRA8 (see all 7) OriGene ORF clones in mouse, rat for MXRA8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MXRA8 (NM_032348)
		Sino Biological Human cDNA Clone for MXRA8
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXRA8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA8

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXRA8

Localization
for MXRA8 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
mitochondrion	2
plasma membrane	2
endoplasmic reticulum	1
extracellular	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for MXRA8 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for MXRA8 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MXRA8 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MXRA8 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MXRA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGGGACTCCA

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Heart (Cardiovascular System)    fully expand to see all 2 entries
Semilunar Valves
Ovary (Reproductive System)
Oviduct
Bone (Muscoskeletal System)
Rib
Testis (Reproductive System)
Leydig Cells Testis Interstitium

Primer Products:		OriGene qPCR primer pairs and template standards for MXRA8 OriGene qSTAR qPCR primer pairs in human, mouse for MXRA8
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MXRA8
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		QuantiFast Probe-based Assays in human, mouse, rat MXRA8

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXRA8

Orthologs
for MXRA8 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MXRA8 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for MXRA8 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MXRA8 (see all 254)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1817121231,2		--	1287588(+)	CTGCAC/GCCAAC	1	--	int1		0	--	--	--	--
rs1406884251,2		--	1287635(+)	GATCCA/GTGCTG	1	--	int1		0	--	--	--	--
rs1456788791,2	C	--	1287732(+)	GACCCA/GCATCC	1	--	int1		0	--	--	--	--
rs1860763201,2		--	1287748(+)	CTCCCA/GCTCCT	1	--	int1		0	--	--	--	--
rs1383376141,2	C	--	1287755(+)	TCCTCA/GTCCCT	1	--	int1		0	--	--	--	--
rs1904508331,2		--	1287896(+)	ACTAGC/GTCAAA	1	--	int1		0	--	--	--	--
rs37661851,2	C	--	1287922(-)	GGAGTT/CGGTGT	1	--	int1		9		EA NA WA CSA	1508
rs1432405911,2		--	1287964(+)	AGGAAC/TGGGAT	1	--	int1		0	--	--	--	--
rs1480498831,2	C	--	1287973(+)	ATGATA/GTCAGG	1	--	int1		0	--	--	--	--
rs354810251,2	C,F	--	1288042(-)	AAACTC/TCGTCT	1	--	int1		2		NA CSA	6

HapMap Linkage Disequilibrium report for MXRA8 (1288069 - 1297157 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MXRA8 (see all 25):    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv17n71	CNV	Loss	21882294
nsv470680	CNV	Loss	18288195
nsv870639	CNV	Loss	21882294
dgv29n71	CNV	Loss	21882294
nsv482937	CNV	Loss	15286789
dgv39n71	CNV	Loss	21882294
dgv12n71	CNV	Loss	21882294
dgv25n71	CNV	Loss	21882294
dgv19n71	CNV	Loss	21882294
nsv870491	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MXRA8

DNA2.0 Custom Variant and Variant Library Synthesis for MXRA8

Disorders / Diseases
for MXRA8 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MXRA8 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. (PubMed id 14603461)^{1, 2, 3} Yonezawa T.... Ninomiya Y. (Glia 2003)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling. (PubMed id 23386276)¹ Han S.W....Choi J.Y. (Cardiovasc. Res. 2013)
4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
5. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)¹ Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
6. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)¹ Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (Nature 2006)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)¹ Clark H.F.... Gray A.M. (Genome Res. 2003)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for MXRA8 gene

Genome Databases showing MXRA8 gene

Other Databases showing MXRA8 gene

Specialized Databases showing MXRA8 gene

Products
for MXRA8 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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