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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MXRA7 Gene

protein-coding GIFtS: 43
GCID: GC17M074671

matrix-remodelling associated 7

Explore 2 diseases affiliated with
MXRA7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Matrix-Remodelling Associated 7¹ ²		FLJ46603¹
TMAP1¹ ² ³		HBV PreS1-Transactivated Protein 1²
PS1TP1¹ ²		Matrix-Remodeling-Associated Protein 7²
Transmembrane Anchor Protein 1² ³

External Ids:	HGNC: 7541¹	Entrez Gene: 439921²	Ensembl: ENSG00000182534⁷	UniProtKB: P84157³

Export aliases for MXRA7 gene to outside databases

Previous GC identifers: GC00U990745 GC17M072187 GC17M070099

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MXRA7 gene promoter:
E2F-4 E2F-3a Max1 E2F-2 Max E2F E2F-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MXRA7 promoter sequence

Search SABiosciences Chromatin IP Primers for MXRA7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXRA7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

MXRA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXRA7 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M074671: view genomic region (about GC identifiers)

Start:	74,668,633 bp from pter	End:	74,707,098 bp from pter
Size:	38,466 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MXRA7_HUMAN, P84157 (See protein sequence)

Recommended Name: Matrix-remodeling-associated protein 7

Size: 204 amino acids; 21466 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Sequence caution: Sequence=AW888225; Type=Frameshift; Positions=Several;

Secondary accessions: Q0P5W3

Alternative splicing: 3 isoforms: P84157-1 P84157-2 P84157-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MXRA7: NX_P84157

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P84157

MXRA7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001008528.1 NP_001008529.1 NP_940932.2

ENSEMBL proteins:

ENSP00000348050 ENSP00000364176 ENSP00000391466 ENSP00000465103 ENSP00000466376

ENSP00000468020 ENSP00000467510

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

MXRA7 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MXRA7 for domains About GeneDecksing

1 InterPro domain/family:

IPR026622 Mxra7

Graphical View of Domain Structure for InterPro Entry P84157

ProtoNet protein and cluster: P84157

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MXRA7

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for MXRA7 (ENSP00000348050⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MXRA7
Search CenterWatch for drugs/clinical trials and news about MXRA7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MXRA7 gene (3 alternative transcripts):

NM_001008528.1 NM_001008529.1 NM_198530.2

Unigene Clusters for MXRA7:

Matrix-remodelling associated 7

Hs.250723 [show with all ESTs], Hs.597019 [show with all ESTs]

Unigene Representative Sequences: NM_001008528, AK097108

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355797(uc002jsk.1) ENST00000375036(uc002jsl.3) ENST00000449428(uc002jsm.3)

ENST00000592148 ENST00000585519 ENST00000588114 ENST00000589082

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		hsa-miR-137 hsa-miR-4299 hsa-miR-513c hsa-miR-520a-5p hsa-miR-2115 hsa-miR-558 hsa-miR-24 hsa-miR-450b-5p

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Additional cDNA sequence: AK097108.1

20 DOTS entries:

DT.100682862 DT.120922770 DT.406860 DT.40311530 DT.101984782 DT.100815503 DT.91939111 DT.120922710

DT.313896 DT.100815498 DT.120922682 DT.95207401 DT.100642257 DT.92053396 DT.92455837 DT.92455850

DT.95207396 DT.219890 DT.95072076 DT.97841044

24/334 AceView cDNA sequences (see all 334):

AL702517 AI373869 AY426672 CK823129 CD514785 AA382978 AA410205 BM716534

AA864644 BI964130 BF059077 C03717 BM930004 AI377689 BQ636895 BQ636080

BM462838 AA354081 AA115306 AA410204 BF434642 BQ613790 AA319575 AI378468

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MXRA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTGGATCT

About this image

MXRA7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MXRA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MXRA7

SOURCE GeneReport for Unigene clusters: Hs.250723 Hs.597019

SABiosciences Custom PCR Arrays for MXRA7

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MXRA7 gene from 4/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mxra7^{1 , 5}	matrix-remodelling associated 7^{1, 5}	80.95(n)¹ 74.86(a)¹		11 (81.49 cM)⁵ 67622¹ NM_026280.3¹ NP_080556.1¹ 116803062⁵
chicken (Gallus gallus)	Aves	MXRA7¹	matrix-remodelling associated 7	59.39(n) 49.24(a)		769894 XM_001233206.2 XP_001233207.2
lizard (Anolis carolinensis)	Reptilia	MXRA7⁶	--	87(a)	1 ↔ 1	2(111755900-111755992)
zebrafish (Danio rerio)	Actinopterygii	mxra7⁶	matrix-remodelling associated 7	61(a)	1 ↔ 1	12(22024148-22028881)

ENSEMBL Gene Tree for MXRA7 (if available)
TreeFam Gene Tree for MXRA7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78608534^1,2	C,F,	--	74671400(+)	`CCCACC/TGATGT`	1	--	ds500¹		1		EA	120
rs186161351^1,2		--	74671434(+)	`GCTGAA/GGTAAG`	1	--	ds500¹		0	--	--	--	--
rs138989735^1,2		--	74671546(+)	`GCGATA/GGCTCA`	1	--	ds500¹		0	--	--	--	--
rs145073719^1,2		--	74671708(+)	`CTGACC/TTCAAG`	1	--	ds500¹		0	--	--	--	--
rs202016964^1,2	C	--	74671838(-)	`CTGTTG/TTTGGA`	1	--	ut3¹		0	--	--	--	--
rs112640261^1,2	C,	--	74671865(+)	`TCAGCA/-AAGAA`	1	--	ut3¹		1		CSA	2
rs200543483^1,2	C	--	74671865(+)	`GTCAGA/CAAGAA`	1	--	ut3¹		0	--	--	--	--
rs67600886^1,2	C	--	74671866(+)	`CAGCAA/-AGAAA`	1	--	ut3¹		1		NA	2
rs200677764^1,2	C	--	74671869(-)	`TTGTTC/TCTTGC`	1	--	ut3¹		0	--	--	--	--
rs11327985^1,2	C,	--	74671992(+)	`TCCAC-/TTTTTT`	1	--	ut3¹ trp³		2		NA CSA	4

HapMap Linkage Disequilibrium report for MXRA7 (74668633 - 74707098 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MXRA7
2 CNVs: 73037 102540
1 Indel: 45593

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MXRA7 for disorders About GeneDecksing

2 diseases for MXRA7: About MalaCards

ovarian endometriosis endometriosis

1 disease from the University of Copenhagen DISEASES database for MXRA7:

Ovarian endometriosis

Export disorders for MXRA7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MXRA7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MXRA7)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 439921	HGNC: 7541	AceView: LOC439921	Ensembl:ENSG00000182534	euGenes: HUgn439921
ECgene: MXRA7	H-InvDB: MXRA7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MXRA7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MXRA7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MXRA7 gene:
Search GeneIP for patents involving MXRA7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXRA7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MXRA7 gene at Home site.

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MXRA7 Gene

matrix-remodelling associated 7

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MXRA7 Gene

matrix-remodelling associated 7

Aliasesfor MXRA7 gene

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for MXRA7 gene

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for MXRA7 gene

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for MXRA7 gene

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for MXRA7 gene

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for MXRA7 gene

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