Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MXRA5 Gene

Aliases for MXRA5 Gene

  • Matrix Remodeling Associated 5 2 3 5
  • Adlican 2 3 4
  • Adhesion Protein With Leucine-Rich Repeats And Immunoglobulin Domains Related To Perlecan 3 4
  • Matrix-Remodelling Associated 5 2 3
  • Matrix-Remodeling-Associated Protein 5 3

External Ids for MXRA5 Gene

Previous GeneCards Identifiers for MXRA5 Gene

  • GC00U990747
  • GC0XM003220
  • GC0XM001169

Summaries for MXRA5 Gene

Entrez Gene Summary for MXRA5 Gene

  • This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]

GeneCards Summary for MXRA5 Gene

MXRA5 (Matrix Remodeling Associated 5) is a Protein Coding gene. Diseases associated with MXRA5 include Lung Cancer. An important paralog of this gene is IGSF10.

Additional gene information for MXRA5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXRA5 Gene

Genomics for MXRA5 Gene

Regulatory Elements for MXRA5 Gene

Enhancers for MXRA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH003518 1.3 FANTOM5 Ensembl ENCODE dbSUPER 25.6 -173.7 -173673 4.7 FOSL1 JUND FOS MXRA5 RNU6-146P ARSF SNORA48B GC0XM003534 GC0XP003465
GH0XH003525 1 FANTOM5 Ensembl ENCODE dbSUPER 27.3 -179.8 -179760 2.7 MXRA5 GC0XM003534 SNORA48B GC0XP003465
GH0XH003529 0.6 ENCODE dbSUPER 21.1 -182.8 -182774 1.1 ATF2 MXRA5 SNORA48B GC0XM003534 GC0XP003465
GH0XH003344 0.5 ENCODE 21.5 +1.1 1073 2.7 E2F1 POLR2A EZH2 MXRA5 GC0XM003252
GH0XH003514 0.5 ENCODE dbSUPER 21.1 -168.7 -168714 2 MXRA5 GC0XM003534 SNORA48B GC0XP003465
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MXRA5 on UCSC Golden Path with GeneCards custom track

Promoters for MXRA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243929 892 2001 E2F1 EZH2

Genomic Locations for MXRA5 Gene

Genomic Locations for MXRA5 Gene
38,528 bases
Minus strand

Genomic View for MXRA5 Gene

Genes around MXRA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MXRA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MXRA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXRA5 Gene

Proteins for MXRA5 Gene

  • Protein details for MXRA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix-remodeling-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6P1M7
    • Q9Y3Y8

    Protein attributes for MXRA5 Gene

    2828 amino acids
    Molecular mass:
    312150 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11846.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH64986.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH80586.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MXRA5 Gene

Post-translational modifications for MXRA5 Gene

  • Glycosylation at posLast=287287, posLast=321321, posLast=633633, Ser1047, posLast=10501050, posLast=13321332, posLast=14031403, posLast=17351735, posLast=18441844, posLast=20072007, Asn2056, and Asn2693
  • Modification sites at PhosphoSitePlus

Other Protein References for MXRA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MXRA5 Gene

Domains & Families for MXRA5 Gene

Gene Families for MXRA5 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MXRA5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MXRA5: view

No data available for UniProtKB/Swiss-Prot for MXRA5 Gene

Function for MXRA5 Gene

Phenotypes From GWAS Catalog for MXRA5 Gene

Gene Ontology (GO) - Molecular Function for MXRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MXRA5: view

Phenotypes for MXRA5 Gene

genes like me logo Genes that share phenotypes with MXRA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MXRA5 Gene

Localization for MXRA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXRA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MXRA5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MXRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MXRA5: view

Pathways & Interactions for MXRA5 Gene

SuperPathways for MXRA5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MXRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0071559 response to transforming growth factor beta IMP 27599751
genes like me logo Genes that share ontologies with MXRA5: view

No data available for Pathways by source and SIGNOR curated interactions for MXRA5 Gene

Drugs & Compounds for MXRA5 Gene

No Compound Related Data Available

Transcripts for MXRA5 Gene

mRNA/cDNA for MXRA5 Gene

Unigene Clusters for MXRA5 Gene

Matrix-remodelling associated 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MXRA5 Gene

No ASD Table

Relevant External Links for MXRA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MXRA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MXRA5 Gene

Protein differential expression in normal tissues from HIPED for MXRA5 Gene

This gene is overexpressed in Amniocyte (39.3), Urine (9.8), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MXRA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MXRA5 Gene:


SOURCE GeneReport for Unigene cluster for MXRA5 Gene:


Evidence on tissue expression from TISSUES for MXRA5 Gene

  • Muscle(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MXRA5: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MXRA5 Gene

Orthologs for MXRA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MXRA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
LOC473896 33
  • 95.45 (n)
-- 34
  • 92 (a)
(Canis familiaris)
Mammalia MXRA5 33 34
  • 78.71 (n)
(Bos Taurus)
Mammalia MXRA5 33 34
  • 74.28 (n)
(Monodelphis domestica)
Mammalia MXRA5 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia MXRA5 34
  • 50 (a)
(Gallus gallus)
Aves MXRA5 33 34
  • 61.25 (n)
(Anolis carolinensis)
Reptilia MXRA5 34
  • 53 (a)
(Danio rerio)
Actinopterygii LOC100151112 33
  • 55.8 (n)
mxra5a 34
  • 39 (a)
mxra5b 34
  • 39 (a)
MXRA5 (3 of 3) 34
  • 35 (a)
Species where no ortholog for MXRA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MXRA5 Gene

Gene Tree for MXRA5 (if available)
Gene Tree for MXRA5 (if available)

Paralogs for MXRA5 Gene

Paralogs for MXRA5 Gene

(1) SIMAP similar genes for MXRA5 Gene using alignment to 2 proteins: Pseudogenes for MXRA5 Gene

genes like me logo Genes that share paralogs with MXRA5: view

Variants for MXRA5 Gene

Sequence variations from dbSNP and Humsavar for MXRA5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs369042203 Lung cancer (LNCR) [MIM:211980] 3,311,158(+) GTTCC(A/G)GATGG reference, missense
rs776590689 Lung cancer (LNCR) [MIM:211980] 3,311,304(+) CATAG(A/C/T)GCTTG reference, missense
VAR_072405 Lung cancer (LNCR) [MIM:211980]
VAR_072406 Lung cancer (LNCR) [MIM:211980]
VAR_072407 Lung cancer (LNCR) [MIM:211980]

Structural Variations from Database of Genomic Variants (DGV) for MXRA5 Gene

Variant ID Type Subtype PubMed ID
nsv1075712 CNV deletion 25765185
esv33979 CNV gain+loss 17666407
esv2665216 CNV deletion 23128226
esv1014244 CNV insertion 17803354

Variation tolerance for MXRA5 Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.31; 92.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MXRA5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXRA5 Gene

Disorders for MXRA5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MXRA5 Gene - From: Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search MXRA5 in MalaCards View complete list of genes associated with diseases


  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269 PubMed:22696596}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for MXRA5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MXRA5: view

No data available for Genatlas for MXRA5 Gene

Publications for MXRA5 Gene

  1. Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. (PMID: 22696596) Xiong D … You M (Carcinogenesis 2012) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Cloning of differentially expressed genes in skin fibroblasts from centenarians. (PMID: 15609104) Chondrogianni N … Gonos ES (Biogerontology 2004) 3 4 60
  4. Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. (PMID: 12101425) Zou TT … Meltzer SJ (Oncogene 2002) 2 3 60
  5. MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties. (PMID: 27599751) Poveda J … Sanchez-Niño MD (Journal of cellular and molecular medicine 2017) 3 60

Products for MXRA5 Gene

Sources for MXRA5 Gene

Loading form....