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MXI1 Gene

protein-coding GIFtS: 60

GC10P111957

MAX interactor 1
(Previous name: MAX interacting protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MAD2 ^¹, ²
MGC43220 ^²
MXD2 ^¹, ²
MXI ^¹, ²
OTTHUMP00000020467 ^²
OTTHUMP00000020468 ^²
OTTHUMP00000020469 ^²
bHLHc11 ^¹, ²

Descriptions
MAX dimerization protein 2 ^²
MAX interacting protein 1 ^¹
MAX interactor 1 ^²
MAX-interacting protein 1 ^²
Max-related transcription factor ^²
Protein MXI1 ^³

External Ids
HGNC: 7534¹
Entrez Gene: 4601²
UniProtKB: P50539³
Ensembl: ENSG00000119950⁷

Search outside databases for aliases for MXI1 gene

Previous GC identifers: GC10P110863 GC10P111203 GC10P112098 GC10P111631

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MXI1:

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly

regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by

this gene is a transcriptional repressor thought to negatively regulate MYC function, and is

therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC

by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for

its function. Defects in this gene are frequently found in patients with prostate tumors. Three

alternatively spliced transcripts encoding different isoforms have been described. Additional

alternatively spliced transcripts may exist but the products of these transcripts have not been

verified experimentally. [provided by RefSeq]

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539

Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding

protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC

transcriptional activity by competing for MAX

Gene Wiki entry for MXI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MXI1 gene

Entrez Gene cytogenetic band: 10q24-q25 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q24-q25

MXI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P111957: (about GC identifiers)

Start:	111,957,353 bp from pter
End:	112,037,113 bp from pter
Size:	79,761 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539 (See protein sequence)

Recommended Name: MAX-interacting protein 1

Size: 228 amino acids; 26062 Da

Subunit: Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with

another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q15887 Q6FHW2

Alternative splicing: 2 isoforms: P50539-1 P50539-2

REFSEQ proteins (3 alternative transcripts):

NP_001008541.1 NP_005953.4 NP_569157.2

ENSEMBL proteins:

ENSP00000358636 ENSP00000331152 ENSP00000239007 ENSP00000376842 ENSP00000354606 ENSP00000358632

ENSP00000358627 ENSP00000358626 ENSP00000358625

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MXI1)
	Human Recombinant Proteins from Abnova (MXI1)

OriGene Purified Recombinant Human Protein: MXI1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	8425219

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Antibodies for MXI1:

	Invitrogen Antibodies for MXI1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MXI1
	R&D Systems Antibodies for MXI1
	Antibodies from Abcam (MXI1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MXI1)
	Novus Biologicals Antibodies for MXI1

Assays for MXI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50539

ProtoNet protein and cluster: P50539

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MXI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MXI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005962

Applied Biosystems Silencer® siRNAs for MXI1

Sigma-Aldrich siRNA for MXI1

Sigma-Aldrich shRNA for MXI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MXI1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001008541
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001008541
untagged cDNA clones in CMV expression vector (see all 4): NM_001008541

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_130439

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539

Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding

protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC

transcriptional activity by competing for MAX

Genatlas biochemistry entry for MXI1:

Max interactor 1,key component of the mitotic checkpoint,induced during terminal

differentiation,interacting with Max to bind Myc-Max recognition E box sites through interaction

between the N terminus and SIN3 corepressor,antagonizing MYC dependent activation and repressing

the c-Myc promoter P2,MYC family (see TSG10A),commonly mutated or deleted in prostate carcinoma

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mxi1):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
life span-post-weaning/aging	renal/urinary system	reproductive system	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8425219
GO:0003714	transcription corepressor activity	TAS	8425219
GO:0030528	transcription regulator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MXI1

5/13 Interacting proteins for MXI1 (ENSP00000331152³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAX	ENSP00000284165³	STRING (score=.999)
DAPK3	ENSP00000301264³	STRING (score=.967)
SIN3A	ENSP00000353622³	STRING (score=.933)
SLC25A21	ENSP00000329452³	STRING (score=.914)
SIN3B	ENSP00000369131³	STRING (score=.891)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	9624006
GO:0042994	cytoplasmic sequestering of transcription factor	TAS	8425219

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MXI1
2 Novoseek chemical compound relationships for MXI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	42.30	5	9399572 (1), 10849326 (1), 15809730 (1), 8827088 (1) (see all 5)
ornithine	17.85	1	8637719 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MXI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MXI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005962

Sigma-Aldrich siRNA for MXI1

Sigma-Aldrich shRNA for MXI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001008541 NM_005962 NM_130439

REFSEQ mRNAs for MXI1 gene (3 alternative transcripts):

NM_001008541.1 NM_005962.4 NM_130439.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001008541 NM_005962 NM_130439

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001008541
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001008541
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001008541

Additional cDNA sequence:

AK303949.1 AK307090.1 AK309718.1 BC012907.1 BC016678.1 BC035128.1 BT007069.1 CR536576.1

CR594058.1 CR616482.1 D63940.1

17 DOTS entries:

DT.99968227 DT.95203282 DT.75126184 DT.100825254 DT.121230908 DT.121231052 DT.121230911 DT.95203272

DT.97822739 DT.121230883 DT.121230932 DT.100825253 DT.40123498 DT.91668039 DT.95203283 DT.100825257

DT.92433500

24/253 AceView cDNA sequences (see all 253 ):

AV726599 BM473621 BM703825 H84757 AA452708 NM_005962 AA342309 BT007069

BQ425277 AI702591 CA435823 AA976717 AA342308 BC016678 AA854855 BP379906

AI288871 CR536576 CB268896 BI493772 BM999562 NM_130439 BX282353 CR594058

highest scoring ESTs for MXI1:

D63940 N71897 AA009641 AA086035 AA114957 AA115514 AA136083 AA176635 AA313550 AA342308

Unigene Cluster for MXI1:

MAX interactor 1

Hs.719185 [show with all ESTs]

Unigene Representative Sequence: NM_130439

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MXI1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c
SP1:							-						-
SP2:													-
SP3:			-		-		-						-
SP4:
SP5:					-		-				-		-

About this scheme

ECgene alternative splicing isoforms for MXI1

9 Ensembl transcripts including schematic representations:

ENST00000369623 ENST00000332674 ENST00000239007 ENST00000393134 ENST00000361248 ENST00000369619

ENST00000369614 ENST00000369613 ENST00000369612

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MXI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MXI1

¹ / ² / ³

7 probe-sets matching MXI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39072_at²^{, 3}	U95-A	1	1.00	1.00	0.86	1.46	L07648	0.80	1.00	0.91	1
654_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.30	L07648	0.80	1.00	0.91	1
53165_at²^{, 3}	U95-C	1	1.00	1.00	0.77	0.97	N71897	1.00	1.00	1.00	1
748_s_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.71	D63940	1.00	1.00	1.00	1
74447_at²^{, 3}	U95-D	1	0.56	1.00	-0.28	0.58	AW016621	0.60	1.00	0.82	1
202364_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005962	0.60	1.00	0.82	1
202364_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGTTTTTCA

SOURCE GeneReport for Unigene cluster: Hs.719185
Expression variation in blood from EXPOLDB for MXI1
UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in
the liver, kidney and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MXI1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MXI1¹	--	MAX interactor 1	96.11(n) 97.25(a)	609946 XM_847302.1 XP_852395.1
chimpanzee (Pan troglodytes)	MXI1¹	--	MAX interactor 1	91.81(n) 91.47(a)	737181 XM_001142168.1 XP_001142168.1
cow (Bos taurus)	MXI1¹	--	MAX interactor 1	96.91(n) 97.59(a)	614509 NM_001076331.1 NP_001069799.1
mouse (Mus musculus)	Mxi1^{1, 5}	19 (49.50 cM)⁵	Max interacting protein 1^{1, 5}	92.43(n)¹ 95.25(a)¹	17859¹ NM_001008542.2¹ NP_001008542.2¹ AA387441⁵ AK140465⁵ (see all 21)
chicken (Gallus gallus)	MXI1¹	--	MAX interactor 1	82.32(n) 85.98(a)	423888 NM_001012911.1 NP_001012929.1

About this table Species with no ortholog for MXI1

ENSEMBL Gene Tree for MXI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MXI1 gene

MXD1² MXD3² MXD4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/402 NCBI SNPs in MXI1 are shown (see all 402 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 132)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1133195^1,2	C,F,H,O	112035132(+)	`GCTTTA/GTGGTC`	3	--	ut3¹ ese³		8		MN NA EU EA WA	744
	rs1891374^1,2	A,C,F,H	111956834(-)	`TCCCAG/AGCCGT`	1	--	ng5¹		8		EU EA WA	832
	rs4918487^1,2	A,C,F,H	111974746(+)	`AGCTAC/TAGAGG`	3	--	ng5¹ int¹		4		EU EA WA	418
	rs17658^1,2	A,C,F,H	112036140(-)	`CCACAG/AGGGAA`	3	--	ut3¹ ese³		13		MN EU EA WA NA	2600
	rs1803997^1,2	C,F,H	112036190(-)	`ACAGCC/AAGGGG`	3	--	ut3¹ ese³		8		EA NA EU WA	1862
	rs14401^1,2	C,F,H	112035161(+)	`CTATTC/TGAATG`	3	--	ut3¹ ese³		18		MN NS EU EA WA NA	1454
	rs12261267^1,2	F,H	111956739(+)	`TGTGGA/GGAGGG`	1	--	ng5¹		4		EU EA WA	416
--	rs4917554^1,2	A,C	111975017(+)	`TCTCAC/GTGTAA`	3	--	int¹ ng5¹		0	--	--	--	--
--	rs16410^1,2	F	112035024(+)	`GTTGATTGA/- GAAGA`	3	--	ut3¹		4		EU NA EA	342
--	rs1475502^1,2	F	111957545(-)	`GCGGGG/AGTCCG`	1	--	ut5¹ ese³		1		MN	184

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HapMap Linkage Disequilibrium images for MXI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600020

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539

Defects in MXI1 are found in some patients with prostate cancer (CaP) [MIM:176807]

10/13 Novoseek disease relationships for MXI1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostatic hyperplasia	53.56	2	11351349 (1), 11490301 (1)
glioblastoma	51.94	12	9354456 (4), 15548375 (2), 7789959 (1), 10470286 (1)
allelic loss	51.02	9	9354456 (3), 14559981 (2), 17102621 (1), 7773287 (1)
myeloid leukemia	40.63	2	8425219 (1), 7500645 (1)
tumors	39.19	66	10849326 (6), 9458379 (5), 14559981 (4), 7585509 (4) (see all 28)
prostate cancer	29.96	20	9458379 (5), 8827088 (4), 9376279 (3), 7773287 (3) (see all 6)
brain tumors	19.79	1	9354456 (1)
prostate carcinoma	16.25	2	7829091 (1), 11351349 (1)
glioma	14.46	1	10470286 (1)
cancer	11.20	3	10849326 (1), 17102621 (1), 15467743 (1)

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Tumor Gene Database: MXI1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/93 PubMed articles for MXI1 gene (see all 93 ):

Genomic organization of human MXI1, a putative tumor suppressor gene. (PubMed id 8838813)^{1, 3, 4} Wechsler D.S.... Dang C.V. (1996)
Mutation of the MXI1 gene in prostate cancer. (PubMed id 7773287)^{1, 3, 4} Eagle L.R....Prochownik E.V. (1995)
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. (PubMed id 8425219)^{1, 3, 4} Zervos A.S.... Brent R. (1993)
Expression, regulation and polymorphism of the mxi1 genes. (PubMed id 8918230)^{1, 3, 4} Shimizu E.... Shimizu B. (1996)
Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. (PubMed id 7789959)^{1, 3, 4} Albarosa R.... Finocchiaro G. (1995)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. (PubMed id 7959753)^{2, 3} Wechsler D.S....Dang C.V. (1994)
Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PubMed id 17577784)^{1, 3} Guo X.L....Ohno R. (2007)
Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. (PubMed id 9669667)^{1, 3} Prochownik E.V....Brothman A.R. (1998)
Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma. (PubMed id 14559981)^{1, 3} Ariyanayagam-Baksh S.M....Finkelstein S.D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4601	HGNC: 7534	AceView: MXI1	Ensembl:ENSG00000119950	euGenes: HUgn4601
ECgene: MXI1	H-InvDB: MXI1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MXI1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MXI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MXI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MXI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MXI1		Antibodies for MXI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MXI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for MXI1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MXI1 Gene at Home site.
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MXI1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for MXI1

Summaries
for MXI1

Genomic Location
for MXI1

Proteins
for MXI1

Protein Domains/
Families
for MXI1

Gene Function
for MXI1

Pathways & Interactions
for MXI1

Drugs & Compounds
for MXI1

Transcripts
for MXI1

Expression
for MXI1

Orthologs
for MXI1

Paralogs
for MXI1

SNPs/Variants
for MXI1

Disorders & Mutations
for MXI1

Medical News
for MXI1

Publications
for MXI1

Search for MXI1

Genome Databases showing MXI1

Other Databases showing MXI1

Specialized Databases showing MXI1

Licensable Technologies
for MXI1

Services
for MXI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MXI1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor MXI1

Summariesfor MXI1

Genomic Locationfor MXI1

Proteinsfor MXI1

Protein Domains/Familiesfor MXI1

Gene Functionfor MXI1

Pathways & Interactionsfor MXI1

Drugs & Compoundsfor MXI1

Transcriptsfor MXI1

Expression for MXI1

Orthologsfor MXI1

Paralogsfor MXI1

SNPs/Variantsfor MXI1

Disorders & Mutationsfor MXI1

Medical Newsfor MXI1

Publicationsfor MXI1

Search for MXI1

Genome Databases showing MXI1

Other Databases showing MXI1

Specialized Databases showing MXI1

Licensable Technologiesfor MXI1

Servicesfor MXI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MXI1

Summaries
for MXI1

Genomic Location
for MXI1

Proteins
for MXI1

Protein Domains/
Families
for MXI1

Gene Function
for MXI1

Pathways & Interactions
for MXI1

Drugs & Compounds
for MXI1

Transcripts
for MXI1

Expression
for MXI1

Orthologs
for MXI1

Paralogs
for MXI1

SNPs/Variants
for MXI1

Disorders & Mutations
for MXI1

Medical News
for MXI1

Publications
for MXI1

Licensable Technologies
for MXI1

Services
for MXI1