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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MXI1 Gene

protein-coding   GIFtS: 55
GCID: GC10P111957

MAX interactor 1, dimerization protein

(Previous names: MAX interacting protein 1, MAX interactor 1 )
 Explore 32 diseases affiliated with
MXI1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MXI1    

Aliases
for MXI1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MAX Interactor 1, Dimerization Protein1 2     Class C Basic Helix-Loop-Helix Protein 112 3
BHLHc111     MAX Interacting Protein 11
MAD21 2     MAX Dimerization Protein 22
MXD21 2     Max-Interacting Protein 12
MXI1 2     Max-Related Transcription Factor2
Max Interactor 11 3     BHLHC113

External Ids:    HGNC: 75341   Entrez Gene: 46012   Ensembl: ENSG000001199507   OMIM: 6000205   UniProtKB: P505393   

Export aliases for MXI1 gene to outside databases

Previous GC identifers: GC10P110863 GC10P111203 GC10P112098 GC10P111631 GC10P105597


Summaries
for MXI1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MXI1:
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells
but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor
thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the
transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is
required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three
alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced
transcripts may exist but the products of these transcripts have not been verified experimentally. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which
recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX

Gene Wiki entry for MXI1


Genomic Views
for MXI1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MXI1 gene promoter:
         FOXO1a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MXI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MXI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q25   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q24-q25

MXI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXI1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P111957:  view genomic region     (about GC identifiers)

Start:
 111,967,363 bp from pter      End:
 112,047,123 bp from pter
Size:
 79,761 bases      Orientation:
 plus strand

Proteins
for MXI1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539 (See protein sequence)
Recommended Name: Max-interacting protein 1  
Size: 228 amino acids; 26062 Da
Subunit: Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein.
Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity)
Subcellular location: Nucleus
Secondary accessions: B1ANN7 D3DR25 D3DRA9 Q15887 Q6FHW2 Q96E53
Alternative splicing: 4 isoforms:  P50539-1   P50539-2   P50539-3   P50539-4   

Explore the universe of human proteins at neXtProt for MXI1: NX_P50539

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50539

    • MXI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008541.1  NP_005953.4  NP_569157.2  

    ENSEMBL proteins: 
     ENSP00000331152   ENSP00000398981   ENSP00000354606   ENSP00000239007   ENSP00000376842  
     ENSP00000358627   ENSP00000358626   ENSP00000407711   ENSP00000358625  

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    Uscn Proteins for MXI1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    MXI1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MXI1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MXI1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P50539

    ProtoNet protein and cluster: P50539

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for MXI1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
    Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which
    recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX

         Genatlas biochemistry entry for MXI1:
    Max interactor 1,key component of the mitotic checkpoint,induced during terminal differentiation,interacting with Max
    to bind Myc-Max recognition E box sites through interaction between the N terminus and SIN3 corepressor,antagonizing
    MYC dependent activation and repressing the c-Myc promoter P2,MYC family (see TSG10A),commonly mutated or deleted in
    prostate carcinoma

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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS8425219
    GO:0046983protein dimerization activity IEA--


    MXI1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MXI1:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Mxi1tm1Rdp for MXI1
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mxi1):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system  tumorigenesis 

    MXI1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MXI1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MXI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for MXI1 (P505393 ENSP000003311524) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE73, ENSP000003547204I2D: score=4 STRING: ENSP00000354720
    SIN3BO751823, ENSP000003691314I2D: score=3 STRING: ENSP00000369131
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    MAXP612443, ENSP000003514904I2D: score=7 STRING: ENSP00000351490
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0008285negative regulation of cell proliferation TAS9624006
    GO:0042994cytoplasmic sequestering of transcription factor TAS8425219


    MXI1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MXI1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MXI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MXI1
    2 Novoseek chemical compound relationships for MXI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 41.3 5 9399572 (1), 10849326 (1), 15809730 (1), 8827088 (1) (see all 5)
    ornithine 16.9 1 8637719 (1)

    Search CenterWatch for drugs/clinical trials and news about MXI1 

    Transcripts
    for MXI1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MXI1 gene (3 alternative transcripts): 
    NM_001008541.1  NM_005962.4  NM_130439.3  

    Unigene Cluster for MXI1:

    MAX interactor 1, dimerization protein
    Hs.744063  [show with all ESTs]
    Unigene Representative Sequence: NM_130439
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332674(uc001kyy.3 uc001kyz.3 uc001kza.3 uc010qrc.2 uc009xxv.3)
    ENST00000453116 ENST00000361248 ENST00000239007 ENST00000460667 ENST00000393134
    ENST00000369614 ENST00000369613 ENST00000484030 ENST00000442296 ENST00000485566
    ENST00000369612

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    hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-105 hsa-miR-1297 hsa-miR-511 hsa-miR-641 hsa-miR-558 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: MXI1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK303949.1 AK307090.1 AK309718.1 BC012907.1 BC016678.1 BC035128.1 BT007069.1 CR536576.1 
    D63940.1 

    17 DOTS entries:

    DT.99968227  DT.95203282  DT.75126184  DT.100825254  DT.121230908  DT.121231052  DT.121230911  DT.95203272 
    DT.97822739  DT.121230883  DT.121230932  DT.100825253  DT.40123498  DT.91668039  DT.95203283  DT.100825257 
    DT.92433500 

    24/253 AceView cDNA sequences (see all 253):

    AI702591 BT007069 AA342309 BE219807 H81252 BQ431433 BM449767 AA854855 
    H84757 CB268896 AV726599 AI288871 BQ425277 BX282353 BM473621 BM703825 
    NM_130439 AA452708 CR616482 AA976717 AA342308 N47455 BM999562 CA435823 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MXI1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                    -                 -                                       
    SP2:                                      -                                       
    SP3:        -     -     -                 -                                       
    SP4:                                                                              
    SP5:              -     -           -     -                                       


    ECgene alternative splicing isoforms for MXI1

    Expression
    for MXI1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MXI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTCCCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MXI1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyEpithelial TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MXI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MXI1

    SOURCE GeneReport for Unigene cluster: Hs.744063

    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
    Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and
    skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including MXI1: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
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    Orthologs
    for MXI1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MXI1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MXI11 MAX interactor 1 82.32(n)
    85.98(a)    		   423888  NM_001012911.1  NP_001012929.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MXI16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 3(45062101-45163283)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.61172 Transcribed sequence with weak similarity to protein more 73.61(n)    137734366 
    zebrafish
    (Danio rerio)    		 Actinopterygii mxi12 max interacting protein 74.09(n)   30485  BC049024.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 76(a)
    42(a)
    		 possible ortholog
    1 ↔ many
    		 GroupUn.3076(4691-4804)
    Group15.19(43588-54079)
    worm
    (Caenorhabditis elegans)    		 Secernentea mdl-16
    		 MAD-Like family member (mdl-1)
    		 21(a)
    		 possible ortholog
    		 X(6742354-6743863)


    ENSEMBL Gene Tree for MXI1 (if available)
    TreeFam Gene Tree for MXI1 (if available) 

    Paralogs
    for MXI1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MXI1 gene
    MXD12  MXD32  MXD42  
    4 SIMAP similar genes for MXI1 using alignment to 5 protein entries:     MXI1_HUMAN (see all proteins):
    MXD1    FLJ00110    MXD4    MXD3

    MXI1 for paralogs           About GeneDecksing



    Genomic Variants
    for MXI1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1236 NCBI SNPs in MXI1 are shown (see all 1236)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs723422541,2
    		C--105675058(+) TCTTT-/AAAAC 
                AAAAC     		2 -- ut310--------
    rs1870095841,2
    		--111965499(+) CTCTGA/GGCTTA 1 -- us2k10--------
    rs1117771021,2
    		C,--111965826(+) CTCCGC/TCTCCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1135459921,2
    		C,--111965866(+) CCGGAG/ATAGCT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1918828561,2
    		--111966022(+) CGTGAG/TCCACT 1 -- us2k10--------
    rs1819010891,2
    		--111966069(+) TGAAGC/TTGCCT 1 -- us2k10--------
    rs1869305121,2
    		--111966297(+) AGGCTC/GTTGCC 1 -- us2k10--------
    rs774327161,2
    		--111966342(+) GGCCAC/GAGTGT 1 -- us2k10--------
    rs1139961711,2
    		--111966393(+) TCAATG/AATGTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1902437471,2
    		--111966405(+) AAACTC/TAGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MXI1 (111967363 - 112047123 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MXI1: --

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    Disorders / Diseases
    for MXI1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MXI1 for disorders           About GeneDecksing

    OMIM gene information: 600020   
    OMIM disorders: 176807  
    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
  • Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy
    • originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the
    prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients
    include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous
    cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and
    neuroendocrine carcinoma

    20/32 diseases for MXI1 (see all 32):    About MalaCards
    prostatitis    neurofibrosarcoma    nevus    transitional cell carcinoma
    basal cell carcinoma    prostate cancer    myeloid leukemia    ulcerative colitis
    familial prostate cancer    renal cell carcinoma    neuroendocrine carcinoma    carcinoma
    shigellosis    multiple sclerosis    bladder carcinoma    prostate carcinoma
    crohn's disease    glioblastoma    medulloblastoma    hepatocellular carcinoma

    10/14 Novoseek disease relationships for MXI1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostatic hyperplasia 52.5 2 11351349 (1), 11490301 (1)
    allelic loss 50.5 9 9354456 (3), 14559981 (2), 17102621 (1), 7773287 (1)
    glioblastoma 50.2 12 9354456 (4), 15548375 (2), 7789959 (1), 10470286 (1)
    myeloid leukemia 39.6 2 8425219 (1), 7500645 (1)
    tumors 38.6 66 10849326 (6), 9458379 (5), 14559981 (4), 7585509 (4) (see all 28)
    prostate cancer 28.2 20 9458379 (5), 8827088 (4), 9376279 (3), 7773287 (3) (see all 6)
    brain tumors 18.2 1 9354456 (1)
    prostate carcinoma 15.2 2 7829091 (1), 11351349 (1)
    glioma 12.7 1 10470286 (1)
    cancer 9.05 3 10849326 (1), 17102621 (1), 15467743 (1)

    Human Genome Epidemiology (HuGE) Navigator: MXI1 (1 document)
    Tumor Gene Database (TGDB): MXI1

    Export disorders for MXI1 gene to outside databases

    Publications
    for MXI1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MXI1 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with MXI1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of human MXI1, a putative tumor suppressor gene. (PubMed id 8838813)1, 2, 9 Wechsler D.S.... Dang C.V. (1996)
    2. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. (PubMed id 8425219)1, 2, 9 Zervos A.S.... Brent R. (1993)
    3. Expression, regulation and polymorphism of the mxi1 genes. (PubMed id 8918230)1, 2, 9 Shimizu E.... Shimizu B. (1996)
    4. Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. (PubMed id 7789959)1, 2, 9 Albarosa R.... Finocchiaro G. (1995)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. (PubMed id 7959753)1, 3 Wechsler D.S....Dang C.V. (1994)
    7. Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas. (PubMed id 15548375)1, 9 Engstrom L.D....Wechsler D.S. (2004)
    8. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PubMed id 17577784)1, 9 Guo X.L....Ohno R. (2007)
    9. [Expression and mutation of myc antagonist genes Mad1, Mxi1 and Rox in leukemia cells] (PubMed id 18457265)1, 9 Suo X.H....Dong Z.R. (2007)
    10. Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. (PubMed id 9669667)1, 9 Prochownik E.V....Brothman A.R. (1998)

    External Searches for MXI1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MXI1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4601 HGNC: 7534 AceView: MXI1 Ensembl:ENSG00000119950 euGenes: HUgn4601
    ECgene: MXI1 H-InvDB: MXI1

    Other Databases showing MXI1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MXI1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MXI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MXI1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MXI1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MXI1 gene:
    Search GeneIP for patents involving MXI1

    GeneCards and IP:
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