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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MXI1 Gene

protein-coding   GIFtS: 59
GCID: GC10P111957

MAX Interactor 1, Dimerization Protein

(Previous names: MAX interacting protein 1, MAX interactor 1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAX Interactor 1, Dimerization Protein1 2     MXD22
Max Interactor 11 3     MXI2
Class C Basic Helix-Loop-Helix Protein 112 3     MAX Dimerization Protein 22
bHLHc112 3     Max-Interacting Protein 12
MAX Interacting Protein 11     Max-Related Transcription Factor2
MAD22     BHLHC113

External Ids:    HGNC: 75341   Entrez Gene: 46012   Ensembl: ENSG000001199507   OMIM: 6000205   UniProtKB: P505393   

Export aliases for MXI1 gene to outside databases

Previous GC identifers: GC10P110863 GC10P111203 GC10P112098 GC10P111631 GC10P105597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MXI1 Gene:
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal
cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional
repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This
protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein
that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with
prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described.
Additional alternatively spliced transcripts may exist but the products of these transcripts have not been
verified experimentally. (provided by RefSeq, Jul 2008)

GeneCards Summary for MXI1 Gene: 
MXI1 (MAX interactor 1, dimerization protein) is a protein-coding gene. Diseases associated with MXI1 include neurofibrosarcoma, and prostate cancer. GO annotations related to this gene include protein dimerization activity and transcription corepressor activity. An important paralog of this gene is MXD1.

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex
which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by
competing for MAX

Gene Wiki entry for MXI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MXI1 gene promoter:
         FOXO1a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MXI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MXI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q25   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q24-q25

MXI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXI1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P111957:  view genomic region     (about GC identifiers)

Start:
111,967,363 bp from pter      End:
112,047,123 bp from pter
Size:
79,761 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539 (See protein sequence)
Recommended Name: Max-interacting protein 1  
Size: 228 amino acids; 26062 Da
Subunit: Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH
protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity)
Subcellular location: Nucleus
Secondary accessions: B1ANN7 D3DR25 D3DRA9 Q15887 Q6FHW2 Q96E53
Alternative splicing: 4 isoforms:  P50539-1   P50539-2   P50539-3   P50539-4   

Explore the universe of human proteins at neXtProt for MXI1: NX_P50539

Explore proteomics data for MXI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50539

  • MXI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MXI1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001008541.1  NP_005953.4  NP_569157.2  

    ENSEMBL proteins: 
     ENSP00000331152   ENSP00000398981   ENSP00000354606   ENSP00000239007   ENSP00000376842  
     ENSP00000407711   ENSP00000358625  

    Human Recombinant Protein Products for MXI1: 
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    Novus Biologicals MXI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MXI1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MXI1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MXD: MAX dimerization proteins
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P50539

    ProtoNet protein and cluster: P50539

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MXI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MXI1_HUMAN, P50539
    Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex
    which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by
    competing for MAX

         Genatlas biochemistry entry for MXI1:
    Max interactor 1,key component of the mitotic checkpoint,induced during terminal differentiation,interacting with
    Max to bind Myc-Max recognition E box sites through interaction between the N terminus and SIN3
    corepressor,antagonizing MYC dependent activation and repressing the c-Myc promoter P2,MYC family (see
    TSG10A),commonly mutated or deleted in prostate carcinoma

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS8425219
    GO:0046983protein dimerization activity IEA--
         
    MXI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MXI1:
     Decreased viability with pacli 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mxi1):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  reproductive system  tumorigenesis 

    MXI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mxi1tm1Rdp for MXI1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MXI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MXI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MXI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MXI1 

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    SwitchGear 3'UTR luciferase reporter plasmidMXI1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MXI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for MXI1 (P505393 ENSP000003311524) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE73, ENSP000003547204I2D: score=4 STRING: ENSP00000354720
    SIN3BO751823, ENSP000003691314I2D: score=3 STRING: ENSP00000369131
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    MAXP612443, ENSP000003514904I2D: score=7 STRING: ENSP00000351490
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008285negative regulation of cell proliferation TAS9624006
    GO:0042994cytoplasmic sequestering of transcription factor TAS8425219

    MXI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MXI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MXI1

    2 Novoseek inferred chemical compound relationships for MXI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 41.3 5 9399572 (1), 10849326 (1), 15809730 (1), 8827088 (1) (see all 5)
    ornithine 16.9 1 8637719 (1)

    Search CenterWatch for drugs/clinical trials and news about MXI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MXI1 gene (3 alternative transcripts): 
    NM_001008541.1  NM_005962.4  NM_130439.3  

    Unigene Cluster for MXI1:

    MAX interactor 1, dimerization protein
    Hs.728542  [show with all ESTs]
    Unigene Representative Sequence: NM_130439
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332674(uc001kyy.3 uc001kyz.3 uc001kza.3 uc010qrc.2 uc009xxv.3)
    ENST00000453116 ENST00000361248 ENST00000239007 ENST00000460667 ENST00000393134
    ENST00000484030 ENST00000442296 ENST00000485566 ENST00000369612
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-105 hsa-miR-1297 hsa-miR-511 hsa-miR-641 hsa-miR-558 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidMXI1 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXI1

    Additional mRNA sequence: 

    AK303949.1 AK307090.1 AK309718.1 BC012907.1 BC016678.1 BC035128.1 BT007069.1 CR536576.1 
    D63940.1 

    17 DOTS entries:

    DT.99968227  DT.95203282  DT.75126184  DT.100825254  DT.121230908  DT.121231052  DT.121230911  DT.95203272 
    DT.97822739  DT.121230883  DT.121230932  DT.100825253  DT.40123498  DT.91668039  DT.95203283  DT.100825257 
    DT.92433500 

    24/253 AceView cDNA sequences (see all 253):

    AI702591 BT007069 AA342309 BE219807 H81252 BQ431433 BM449767 AA854855 
    H84757 CB268896 AV726599 AI288871 BQ425277 BX282353 BM473621 BM703825 
    NM_130439 AA452708 CR616482 AA976717 AA342308 N47455 BM999562 CA435823 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MXI1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                    -                 -                                       
    SP2:                                      -                                       
    SP3:        -     -     -                 -                                       
    SP4:                                                                              
    SP5:              -     -           -     -                                       


    ECgene alternative splicing isoforms for MXI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MXI1 expression in normal human tissues (normalized intensities)      MXI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCCTTT
    MXI1 Expression
    About this image


    MXI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Kidney (Urinary System)
             Epithelial Tubule

    See MXI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MXI1

    SOURCE GeneReport for Unigene cluster: Hs.728542

    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
    Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver,
    kidney and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including MXI1: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MXI1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mxi11 , 5 Max interacting protein 11, 5 92.43(n)1
    95.25(a)1
      19 (47.53 cM)5
    178591  NM_001008542.21  NP_001008542.21 
     533105065 
    chicken
    (Gallus gallus)
    Aves MXI11 MAX interactor 1 82.32(n)
    85.98(a)
      423888  NM_001012911.1  NP_001012929.1 
    lizard
    (Anolis carolinensis)
    Reptilia MXI16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    3(45062101-45163295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.61172 Transcribed sequence with weak similarity to protein more 73.61(n)    137734366 
    zebrafish
    (Danio rerio)
    Actinopterygii mxi12 max interacting protein 74.09(n)   30485  BC049024.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdl-16
    Protein MDL-1
    22(a)
    1 → many
    X(6742393-6743902)


    ENSEMBL Gene Tree for MXI1 (if available)
    TreeFam Gene Tree for MXI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MXI1 gene
    MXD12  MXD32  MXD42  
    4 SIMAP similar genes for MXI1 using alignment to 5 protein entries:     MXI1_HUMAN (see all proteins):
    MXD1    FLJ00110    MXD4    MXD3

    MXI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1488 SNPs in MXI1 are shown (see all 1488)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0044994
    Prostate cancer (PC)4--see VAR_0044992 E A mis40--------
    rs1870095841,2
    --111965499(+) CTCTGA/GGCTTA 1 -- us2k10--------
    rs1117771021,2
    C,F--111965826(+) CTCCGC/TCTCCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1135459921,2
    C,F--111965866(+) CCGGAG/ATAGCT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1918828561,2
    --111966022(+) CGTGAG/TCCACT 1 -- us2k10--------
    rs1819010891,2
    --111966069(+) TGAAGC/TTGCCT 1 -- us2k10--------
    rs1869305121,2
    --111966297(+) AGGCTC/GTTGCC 1 -- us2k10--------
    rs774327161,2
    F--111966342(+) GGCCAC/GAGTGT 1 -- us2k10--------
    rs1139961711,2
    F--111966393(+) TCAATG/AATGTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1902437471,2
    --111966405(+) AAACTC/TAGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MXI1 (111967363 - 112047123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MXI1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673748CNV Deletion23128226
    esv2673572CNV Deletion23128226
    esv2740795CNV Deletion23290073
    esv2740807CNV Deletion23290073
    esv275343CNV Loss21479260
    nsv524405CNV Loss19592680
    nsv896001CNV Loss21882294
    nsv7211OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600020   
    OMIM disorders: 176807  
    UniProtKB/Swiss-Prot: MXI1_HUMAN, P50539
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility
    is associated with variations affecting the gene represented in this entry

  • 20/29 diseases for MXI1 (see all 29):    About MalaCards
    neurofibrosarcoma    prostate cancer    familial prostate cancer    neuroendocrine carcinoma
    shigellosis    prostatitis    small cell carcinoma    glioblastoma
    adenoid cystic carcinoma    bladder carcinoma    transitional cell carcinoma    adenoiditis
    basal cell carcinoma    medulloblastoma    melanoma    ulcerative colitis
    crohn's disease    hypoxia    neuroblastoma    renal cell carcinoma


    MXI1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/14 Novoseek inferred disease relationships for MXI1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostatic hyperplasia 52.5 2 11351349 (1), 11490301 (1)
    allelic loss 50.5 9 9354456 (3), 14559981 (2), 17102621 (1), 7773287 (1)
    glioblastoma 50.2 12 9354456 (4), 15548375 (2), 7789959 (1), 10470286 (1)
    myeloid leukemia 39.6 2 8425219 (1), 7500645 (1)
    tumors 38.6 66 10849326 (6), 9458379 (5), 14559981 (4), 7585509 (4) (see all 28)
    prostate cancer 28.2 20 9458379 (5), 8827088 (4), 9376279 (3), 7773287 (3) (see all 6)
    brain tumors 18.2 1 9354456 (1)
    prostate carcinoma 15.2 2 7829091 (1), 11351349 (1)
    glioma 12.7 1 10470286 (1)
    cancer 9.05 3 10849326 (1), 17102621 (1), 15467743 (1)

    Genetic Association Database (GAD): MXI1
    Human Genome Epidemiology (HuGE) Navigator: MXI1 (1 document)
    Tumor Gene Database (TGDB): MXI1

    Export disorders for MXI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MXI1 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with MXI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of human MXI1, a putative tumor suppressor gene. (PubMed id 8838813)1, 2, 9 Wechsler D.S.... Dang C.V. (1996)
    2. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. (PubMed id 8425219)1, 2, 9 Zervos A.S.... Brent R. (1993)
    3. Expression, regulation and polymorphism of the mxi1 genes. (PubMed id 8918230)1, 2, 9 Shimizu E.... Shimizu B. (1996)
    4. Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. (PubMed id 7789959)1, 2, 9 Albarosa R.... Finocchiaro G. (1995)
    5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1, 4 Baranzini S.E....Oksenberg J.R. (2008)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. (PubMed id 7959753)1, 3 Wechsler D.S....Dang C.V. (1994)
    9. Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas. (PubMed id 15548375)1, 9 Engstrom L.D....Wechsler D.S. (2004)
    10. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PubMed id 17577784)1, 9 Guo X.L....Ohno R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4601 HGNC: 7534 AceView: MXI1 Ensembl:ENSG00000119950 euGenes: HUgn4601
    ECgene: MXI1 H-InvDB: MXI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MXI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MXI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MXI1 gene:
    Search GeneIP for patents involving MXI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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