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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MXD4 Gene

protein-coding   GIFtS: 56
GCID: GC04M002249

MAX dimerization protein 4
 Explore 8 diseases affiliated with
MXD4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MXD4    

Aliases
for MXD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MAX Dimerization Protein 41 2     Max Dimerizer 42 3
MAD41 2 3     Max-Associated Protein 42 3
BHLHc121     Max-Interacting Transcriptional Repressor MAD42 3
MST1491 2     Mad4 Homolog2
MSTP1491 2     BHLHC123
Class C Basic Helix-Loop-Helix Protein 122 3     

External Ids:    HGNC: 139061   Entrez Gene: 106082   Ensembl: ENSG000001239337   UniProtKB: Q145823   

Export aliases for MXD4 gene to outside databases

Previous GC identifers: GC04M002116 GC04M002210 GC04M002216


Summaries
for MXD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MXD4:
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that
heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX
binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents
suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating
tissues. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
suppresses MYC dependent cell transformation (By similarity)

Gene Wiki entry for MXD4


Genomic Views
for MXD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MXD4 gene promoter:
         LHX3b/Lhx3b   NF-1/L   NF-1   RP58   MIF-1   HEN1   FAC1   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MXD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MXD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXD4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002249:  view genomic region     (about GC identifiers)

Start:
 2,249,159 bp from pter      End:
 2,264,021 bp from pter
Size:
 14,863 bases      Orientation:
 minus strand

Proteins
for MXD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582 (See protein sequence)
Recommended Name: Max dimerization protein 4  
Size: 209 amino acids; 23528 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A2A335 Q5TZX4

Explore the universe of human proteins at neXtProt for MXD4: NX_Q14582

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14582

    • MXD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006445.1  
    ENSEMBL proteins: 
     ENSP00000337889   ENSP00000422660   ENSP00000421209  

    Human Recombinant Protein Products: 
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    Novus Biologicals MXD4 Protein
    Novus Biologicals MXD4 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MXD4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    MXD4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MXD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MXD4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q14582

    ProtoNet protein and cluster: Q14582

    UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for MXD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582
    Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
    recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
    suppresses MYC dependent cell transformation (By similarity)

    miRNA
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    hsa-mir-1 (MIRT002761)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MXD4
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MXD4 (see all 57):
    hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-374c hsa-miR-124 hsa-miR-3908 hsa-miR-506
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MXD4 (see all 7)
    OriGene shRNA RFP: MXD4
    OriGene siRNA: MXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXD4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MXD4

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MXD4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS8521822
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--


    MXD4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MXD4:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for MXD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated targets of C-MYC transcriptional repression
    		Validated targets of C-MYC transcriptional repression1.00


    1 BioSystems Pathway for MXD4 
        Validated targets of C-MYC transcriptional repression


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MXD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for MXD4 (Q145823 ENSP000003378894) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXQ9UH923, ENSP000002469124I2D: score=3 STRING: ENSP00000246912
    SMC3Q9UQE73, ENSP000003547204I2D: score=1 STRING: ENSP00000354720
    MAXP612443, ENSP000003514904I2D: score=4 STRING: ENSP00000351490
    TCP10LQ8TDR43, ENSP000003002584I2D: score=3 STRING: ENSP00000300258
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8521822
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008285negative regulation of cell proliferation TAS8521822
    GO:0045892negative regulation of transcription, DNA-dependent ----


    MXD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MXD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MXD4
    Search CenterWatch for drugs/clinical trials and news about MXD4 / MAD4 

    Transcripts
    for MXD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MXD4 gene: 
    NM_006454.2  

    Unigene Cluster for MXD4:

    MAX dimerization protein 4
    Hs.655020  [show with all ESTs]
    Unigene Representative Sequence: AK024501
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337190(uc003geu.1) ENST00000513372 ENST00000513380 ENST00000515378(uc003gev.1)
    ENST00000510822

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MXD4
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    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MXD4 (see all 57):
    hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-374c hsa-miR-124 hsa-miR-3908 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MXD4 (see all 7)
    OriGene shRNA RFP: MXD4
    OriGene siRNA: MXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXD4
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXD4

    Additional cDNA sequence: 

    AF040963.1 AF082740.1 AF187724.1 AK024501.1 AK026392.1 BC002713.2 BC028340.2 BC068060.1 
    BT019969.1 BT019970.1 

    17 DOTS entries:

    DT.87046003  DT.97773673  DT.449179  DT.86821205  DT.121217492  DT.97787825  DT.86857936  DT.95368484 
    DT.97817846  DT.99968522  DT.121217483  DT.449180  DT.95174692  DT.100794121  DT.121217495  DT.121217454 
    DT.86821210 

    24/376 AceView cDNA sequences (see all 376):

    AI693098 AA133420 BM460648 BM787176 AI081233 AI147625 AI205887 BM712182 
    AI912581 AI985142 AW966167 AI703268 AL040188 BM670243 AA720968 BF195473 
    AI243870 AI685659 AW468729 CA942634 CD672778 BM126238 AI143835 BE890163 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MXD4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
    SP1:              -     -           -     -                                 
    SP2:              -                                                         
    SP3:                                      -                                 
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for MXD4

    Expression
    for MXD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MXD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTCTGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MXD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MXD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MXD4

    SOURCE GeneReport for Unigene cluster: Hs.655020
        SABiosciences Custom PCR Arrays for MXD4
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    In Situ
    Assay Products:     
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    Orthologs
    for MXD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MXD4 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MXD41 MAX dimerization protein 4 74.67(n)
    84.5(a)    		   422890  NM_001006460.1  NP_001006460.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MXD46
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343297.1(253687-271937)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.4862 Xenopus laevis basic helix-loop-helix transcription more 74.01(n)    AF127039.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mxd41 MAX dimerization protein 4 70.81(n)
    78.61(a)    		   559531  XM_682878.5  XP_687970.5 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 66(a)
    49(a)
    		 possible ortholog
    1 ↔ many
    		 GroupUn.3076(4691-4804)
    Group15.19(43588-54079)
    worm
    (Caenorhabditis elegans)    		 Secernentea mdl-16
    		 MAD-Like family member (mdl-1)
    		 20(a)
    		 possible ortholog
    		 X(6742354-6743863)


    ENSEMBL Gene Tree for MXD4 (if available)
    TreeFam Gene Tree for MXD4 (if available) 

    Paralogs
    for MXD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MXD4 gene
    MXI12  MXD12  MXD32  
    4 SIMAP similar genes for MXD4 using alignment to 4 protein entries:     MAD4_HUMAN (see all proteins):
    FLJ00110    MXD1    MXD3    MXI1

    MXD4 for paralogs           About GeneDecksing



    Genomic Variants
    for MXD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MXD4
         1 CNV: 68621
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MXD4
    DNA2.0 Custom Variant and Variant Library Synthesis for MXD4

    Disorders / Diseases
    for MXD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MXD4 for disorders           About GeneDecksing

    8 diseases for MXD4:    About MalaCards
    progressive multifocal leukoencephalopathy    williams-beuren syndrome    color blindness    oligodendroglioma
    pharyngitis    blindness    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MXD4:
    Progressive multifocal leukoencephalopathy

    1 Novoseek disease relationship for MXD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11420421 (1)


    Export disorders for MXD4 gene to outside databases

    Publications
    for MXD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MXD4 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MXD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. (PubMed id 8521822)1, 3 Hurlin P.J....Eisenman R.N. (1995)
    4. Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors. (PubMed id 10593926)1, 9 Billin A.N.... Ayer D.E. (1999)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. (PubMed id 16167342)1 Marcotte R....Wang E. (2005)
    7. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Human liver specific transcriptional factor TCP10L binds to MAD4. (PubMed id 15469726)1 Jiang D.J....Yu L. (2004)
    10. Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. (PubMed id 12418961)1 Kime L. and Wright S.C. (2003)

    External Searches for MXD4 gene

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    Genome Databases showing MXD4 gene

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    Entrez Gene: 10608 HGNC: 13906 AceView: MXD4 Ensembl:ENSG00000123933 euGenes: HUgn10608
    ECgene: MXD4 H-InvDB: MXD4

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    Specialized Databases showing MXD4 gene

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