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MXD4 Gene

protein-coding   GIFtS: 55
GCID: GC04M002249

MAX Dimerization Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAX Dimerization Protein 41 2     bHLHc122 3
Class C Basic Helix-Loop-Helix Protein 122 3     MST1492
Max Dimerizer 42 3     MSTP1492
Max-Associated Protein 42 3     Mad4 Homolog2
Max-Interacting Transcriptional Repressor MAD42 3     BHLHC123
MAD42 3     

External Ids:    HGNC: 139061   Entrez Gene: 106082   Ensembl: ENSG000001239337   UniProtKB: Q145823   

Export aliases for MXD4 gene to outside databases

Previous GC identifers: GC04M002116 GC04M002210 GC04M002216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MXD4 Gene:
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins
that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for
MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in
rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in
differentiating tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for MXD4 Gene:
MXD4 (MAX dimerization protein 4) is a protein-coding gene. Diseases associated with MXD4 include progressive multifocal leukoencephalopathy, and color blindness. GO annotations related to this gene include protein dimerization activity and transcription corepressor activity. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
suppresses MYC dependent cell transformation (By similarity)

Gene Wiki entry for MXD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MXD4 gene promoter:
         LHX3b/Lhx3b   NF-1/L   NF-1   RP58   MIF-1   HEN1   FAC1   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMXD4 promoter sequence
   Search Chromatin IP Primers for MXD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXD4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002249:  view genomic region     (about GC identifiers)

Start:
2,249,159 bp from pter      End:
2,264,021 bp from pter
Size:
14,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582 (See protein sequence)
Recommended Name: Max dimerization protein 4  
Size: 209 amino acids; 23528 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity)
Secondary accessions: A2A335 Q5TZX4

Explore the universe of human proteins at neXtProt for MXD4: NX_Q14582

Explore proteomics data for MXD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys96, Lys116
  • Modification sites at PhosphoSitePlus

  • See MXD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006445.1  
    ENSEMBL proteins: 
     ENSP00000337889   ENSP00000422660   ENSP00000421209  

    MXD4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for MXD4
    Cloud-Clone Corp. CLIAs for MXD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MXD: MAX dimerization proteins
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q14582

    ProtoNet protein and cluster: Q14582

    UniProtKB/Swiss-Prot: MAD4_HUMAN, Q14582
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MXD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAD4_HUMAN, Q14582
    Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
    recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
    suppresses MYC dependent cell transformation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS8521822
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    MXD4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MXD4:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MXD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MXD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MXD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MXD4:
    hsa-mir-124-3p (MIRT022628), hsa-mir-378a-3p (MIRT043901), hsa-mir-1 (MIRT002761), hsa-mir-335-5p (MIRT017888)

    Block miRNA regulation of human, mouse, rat MXD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MXD4 (see all 57):
    hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-374c hsa-miR-124 hsa-miR-3908 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MXD4

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXD4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAD4_HUMAN, Q14582: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MXD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MXD4 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression


    1 BioSystems Pathway for MXD4
        Validated targets of C-MYC transcriptional repression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MXD4
    Interactions:

        GeneGlobe Interaction Network for MXD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for MXD4 (Q145823 ENSP000003378894) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLXQ9UH923, ENSP000002469124I2D: score=3 STRING: ENSP00000246912
    SMC3Q9UQE73, ENSP000003547204I2D: score=1 STRING: ENSP00000354720
    MAXP612443, ENSP000003514904I2D: score=4 STRING: ENSP00000351490
    TCP10LQ8TDR43, ENSP000003002584I2D: score=3 STRING: ENSP00000300258
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8521822
    GO:0006351transcription, DNA-templated IEA--
    GO:0008285negative regulation of cell proliferation TAS8521822
    GO:0045892negative regulation of transcription, DNA-templated ----

    MXD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MXD4 (MAD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MXD4 gene: 
    NM_006454.2  

    Unigene Cluster for MXD4:

    MAX dimerization protein 4
    Hs.655020  [show with all ESTs]
    Unigene Representative Sequence: AK024501
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337190(uc003geu.1) ENST00000513372 ENST00000513380 ENST00000515378(uc003gev.1)
    ENST00000510822
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MXD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MXD4 (see all 57):
    hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-342-3p hsa-miR-374c hsa-miR-124 hsa-miR-3908 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MXD4
    Predesigned siRNA for gene silencing in human, mouse, rat MXD4
    Clone
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    OriGene clones in human, mouse for MXD4 (see all 6)
    OriGene ORF clones in mouse, rat for MXD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MXD4 (NM_006454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXD4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MXD4
    OriGene qSTAR qPCR primer pairs in human, mouse for MXD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MXD4
      QuantiTect SYBR Green Assays in human, mouse, rat MXD4
      QuantiFast Probe-based Assays in human, mouse, rat MXD4

    Additional mRNA sequence: 

    AF040963.1 AF082740.1 AF187724.1 AK024501.1 AK026392.1 BC002713.2 BC028340.2 BC068060.1 
    BT019969.1 BT019970.1 

    17 DOTS entries:

    DT.87046003  DT.97773673  DT.449179  DT.86821205  DT.121217492  DT.97787825  DT.86857936  DT.95368484 
    DT.97817846  DT.99968522  DT.121217483  DT.449180  DT.95174692  DT.100794121  DT.121217495  DT.86821210 
    DT.121217454 

    Selected AceView cDNA sequences (see all 376):

    BF447192 BE048473 BE501879 AA040288 AI203971 AF040963 BM720885 CA308842 
    CA432064 BQ946678 AA351599 CF457183 NM_006454 AI693098 AW468729 AI147625 
    BM126270 AW274571 AI831681 AI741352 CN484071 BM665141 AW003564 AI141863 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MXD4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
    SP1:              -     -           -     -                                 
    SP2:              -                                                         
    SP3:                                      -                                 
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for MXD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MXD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCTGCTG
    MXD4 Expression
    About this image


    MXD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Testis (Reproductive System)
     
     Adipose (Muscoskeletal System)
    MXD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MXD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655020
        Custom PCR Arrays for MXD4
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MXD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MXD4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mxd41 , 5 Max dimerization protein 41, 5 87.88(n)1
    91.87(a)1
      5 (17.84 cM)5
    171221  NM_010753.21  NP_034883.21 
     341738875 
    chicken
    (Gallus gallus)
    Aves MXD41 MAX dimerization protein 4 74.3(n)
    84.08(a)
      422890  NM_001006460.1  NP_001006460.1 
    lizard
    (Anolis carolinensis)
    Reptilia MXD46
    MAX dimerization protein 4
    74(a)
    1 ↔ 1
    GL343297.1(252371-272178)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4862 Xenopus laevis basic helix-loop-helix transcription more 74.01(n)    AF127039.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mxd41 MAX dimerization protein 4 72.5(n)
    81(a)
      559531  XM_682878.6  XP_687970.6 
    worm
    (Caenorhabditis elegans)
    Secernentea mdl-16
    Protein MDL-1 (mdl-1) mRNA, complete cds
    24(a)
    1 → many
    X(6742393-6743902) WBGene00003163


    ENSEMBL Gene Tree for MXD4 (if available)
    TreeFam Gene Tree for MXD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MXD4 gene
    MXI12  MXD12  MXD32  
    4 SIMAP similar genes for MXD4 using alignment to 4 protein entries:     MAD4_HUMAN (see all proteins):
    FLJ00110    MXD1    MXD3    MXI1

    MXD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MXD4 (see all 291)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737969951,2
    C,F--2248708(+) CGATTC/TTCACA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1156211491,2
    C,F--2248762(+) GCTGGC/TACGGA 1 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1414582061,2
    --2248874(+) TTGGCC/TAACAG 1 -- ds50010--------
    rs1866844401,2
    --2248965(+) GGCCCA/GGTGTG 1 -- ds50010--------
    rs1142940851,2
    --2249042(+) GGCCAC/TGGCCC 1 -- ds50010--------
    rs1161661501,2
    F--2249043(+) GCCACG/AGCCCG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1158122231,2
    F--2249048(+) GGCCCG/CAAGGC 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1145295771,2
    C,F--2249072(+) GCCATT/GGGGCC 1 -- ds50011Minor allele frequency- G:0.12WA 118
    rs1435950531,2
    --2249109(+) AGGGCA/GCGAAG 1 -- ds50010--------
    rs7628321,2
    C,F,O,H--2249111(-) TGCTTC/TGCGCC 1 -- ds500123Minor allele frequency- T:0.26EA NA NS WA CSA 2458

    HapMap Linkage Disequilibrium report for MXD4 (2249159 - 2264021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MXD4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726835CNV Deletion23290073
    nsv508990CNV Insertion20534489
    nsv4200CNV Insertion18451855
    nsv527189CNV Loss19592680
    dgv312n21CNV Loss19592680
    dgv5422n71CNV Loss21882294
    nsv829838CNV Loss17160897
    nsv878424CNV Loss21882294
    esv24467CNV Loss19812545
    nsv878423CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MXD4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for MXD4:    
    About MalaCards
    progressive multifocal leukoencephalopathy    color blindness    williams-beuren syndrome    oligodendroglioma
    blindness    glioblastoma multiforme    prostatitis

    1 disease from the University of Copenhagen DISEASES database for MXD4:
    Progressive multifocal leukoencephalopathy

    MXD4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MXD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11420421 (1)


    Export disorders for MXD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MXD4 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with MXD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. (PubMed id 8521822)1, 3 Hurlin P.J....Eisenman R.N. (EMBO J. 1995)
    4. Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors. (PubMed id 10593926)1, 9 Billin A.N.... Ayer D.E. (J. Biol. Chem. 1999)
    5. Dissecting the complex regulation of Mad4 in glioblastoma multiforme cells. (PubMed id 22895069)1 Yang W....Dorsey J.F. (amp 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. (PubMed id 16167342)1 Marcotte R....Wang E. (J. Cell. Biochem. 2005)
    10. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (J. Steroid Biochem. Mol. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10608 HGNC: 13906 AceView: MXD4 Ensembl:ENSG00000123933 euGenes: HUgn10608
    ECgene: MXD4 H-InvDB: MXD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MXD4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MXD4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MXD4 gene:
    Search GeneIP for patents involving MXD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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