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Aliases for MXD4 Gene

Aliases for MXD4 Gene

  • MAX Dimerization Protein 4 2 3 5
  • Max-Interacting Transcriptional Repressor MAD4 3 4
  • Class C Basic Helix-Loop-Helix Protein 12 3 4
  • Max-Associated Protein 4 3 4
  • Max Dimerizer 4 3 4
  • BHLHc12 3 4
  • MAD4 3 4
  • Mad4 Homolog 3
  • MSTP149 3
  • MST149 3

External Ids for MXD4 Gene

Previous GeneCards Identifiers for MXD4 Gene

  • GC04M002116
  • GC04M002210
  • GC04M002216

Summaries for MXD4 Gene

Entrez Gene Summary for MXD4 Gene

  • This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for MXD4 Gene

MXD4 (MAX Dimerization Protein 4) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include protein dimerization activity and transcription corepressor activity. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot for MXD4 Gene

  • Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Gene Wiki entry for MXD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXD4 Gene

Genomics for MXD4 Gene

Regulatory Elements for MXD4 Gene

Enhancers for MXD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MXD4 on UCSC Golden Path with GeneCards custom track

Promoters for MXD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MXD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MXD4 Gene

Chromosome:
4
Start:
2,247,432 bp from pter
End:
2,262,294 bp from pter
Size:
14,863 bases
Orientation:
Minus strand

Genomic View for MXD4 Gene

Genes around MXD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MXD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MXD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXD4 Gene

Proteins for MXD4 Gene

  • Protein details for MXD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14582-MAD4_HUMAN
    Recommended name:
    Max dimerization protein 4
    Protein Accession:
    Q14582
    Secondary Accessions:
    • A2A335
    • Q5TZX4

    Protein attributes for MXD4 Gene

    Size:
    209 amino acids
    Molecular mass:
    23528 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).

neXtProt entry for MXD4 Gene

Proteomics data for MXD4 Gene at MOPED

Post-translational modifications for MXD4 Gene

  • Ubiquitination at Lys 77, Lys 96, and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for MXD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MXD4 Gene

Domains & Families for MXD4 Gene

Protein Domains for MXD4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MXD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q14582

UniProtKB/Swiss-Prot:

MAD4_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MXD4: view

Function for MXD4 Gene

Molecular function for MXD4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Gene Ontology (GO) - Molecular Function for MXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MXD4: view
genes like me logo Genes that share phenotypes with MXD4: view

Animal Model Products

miRNA for MXD4 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MXD4 Gene

Localization for MXD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MXD4 Gene COMPARTMENTS Subcellular localization image for MXD4 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for MXD4 Gene

Pathways & Interactions for MXD4 Gene

genes like me logo Genes that share pathways with MXD4: view

Pathways by source for MXD4 Gene

1 BioSystems pathway for MXD4 Gene

Gene Ontology (GO) - Biological Process for MXD4 Gene

None

No data available for SIGNOR curated interactions for MXD4 Gene

Drugs & Compounds for MXD4 Gene

No Compound Related Data Available

Transcripts for MXD4 Gene

Unigene Clusters for MXD4 Gene

MAX dimerization protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MXD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for MXD4 Gene

GeneLoc Exon Structure for
MXD4
ECgene alternative splicing isoforms for
MXD4

Expression for MXD4 Gene

mRNA expression in normal human tissues for MXD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MXD4 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MXD4 Gene



SOURCE GeneReport for Unigene cluster for MXD4 Gene Hs.655020

genes like me logo Genes that share expression patterns with MXD4: view

Protein tissue co-expression partners for MXD4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MXD4 Gene

Orthologs for MXD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MXD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MXD4 35
  • 91.39 (n)
  • 90.91 (a)
MXD4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MXD4 35
  • 91.07 (n)
  • 91.87 (a)
MXD4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mxd4 35
  • 87.88 (n)
  • 91.87 (a)
Mxd4 16
Mxd4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MXD4 35
  • 99.78 (n)
  • 100 (a)
MXD4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MXD4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MXD4 35
  • 74.3 (n)
  • 84.08 (a)
MXD4 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXD4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mxd4 35
  • 71.19 (n)
  • 82.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.486 35
zebrafish
(Danio rerio)
Actinopterygii mxd4 35
  • 72.5 (n)
  • 81 (a)
MXD4 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdl-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 36
  • 36 (a)
OneToMany
Species with no ortholog for MXD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MXD4 Gene

ENSEMBL:
Gene Tree for MXD4 (if available)
TreeFam:
Gene Tree for MXD4 (if available)

Paralogs for MXD4 Gene

Paralogs for MXD4 Gene

(4) SIMAP similar genes for MXD4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MXD4: view

Variants for MXD4 Gene

Sequence variations from dbSNP and Humsavar for MXD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11649 -- 2,249,484(+) TGCCA(C/G)CTGAA nc-transcript-variant, utr-variant-3-prime
rs880674 -- 2,248,382(+) CTGCC(C/T)CAGGC nc-transcript-variant, utr-variant-3-prime
rs762832 -- 2,247,384(-) TGCTT(C/T)GCGCC downstream-variant-500B
rs1052655 -- 2,247,524(-) CGCTA(A/G)AGGGG nc-transcript-variant, utr-variant-3-prime
rs2094365 -- 2,253,738(-) TCCTT(C/T)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MXD4 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv829838 CNV Loss 17160897
nsv878423 CNV Loss 21882294
nsv878424 CNV Loss 21882294
dgv5421n71 CNV Loss 21882294
dgv5422n71 CNV Loss 21882294
nsv527189 CNV Loss 19592680
dgv312n21 CNV Loss 19592680
nsv508990 CNV Insertion 20534489
nsv4200 CNV Insertion 18451855
esv24467 CNV Loss 19812545

Variation tolerance for MXD4 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MXD4 Gene

HapMap Linkage Disequilibrium report
MXD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXD4 Gene

Disorders for MXD4 Gene

Relevant External Links for MXD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MXD4

No disorders were found for MXD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXD4 Gene

Publications for MXD4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Mlx, a novel Max-like bHLHZip protein that interacts with the Max network of transcription factors. (PMID: 10593926) Billin A.N. … Ayer D.E. (J. Biol. Chem. 1999) 3 23
  3. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. (PMID: 8521822) Hurlin P.J. … Eisenman R.N. (EMBO J. 1995) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MXD4 Gene

Sources for MXD4 Gene

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