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Aliases for MXD3 Gene

Aliases for MXD3 Gene

  • MAX Dimerization Protein 3 2 3 5
  • Max-Interacting Transcriptional Repressor MAD3 3 4
  • Class C Basic Helix-Loop-Helix Protein 13 3 4
  • Max-Associated Protein 3 3 4
  • Max Dimerizer 3 3 4
  • BHLHC13 3 4
  • MAD3 3 4
  • MYX 3 4

External Ids for MXD3 Gene

Previous GeneCards Identifiers for MXD3 Gene

  • GC05M177575
  • GC05M176668
  • GC05M176713
  • GC05M176715
  • GC05M176665
  • GC05M176666
  • GC05M176732
  • GC05M171653
  • GC05M176733
  • GC05M176744
  • GC05M177302

Summaries for MXD3 Gene

Entrez Gene Summary for MXD3 Gene

  • This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for MXD3 Gene

MXD3 (MAX Dimerization Protein 3) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot for MXD3 Gene

  • Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXD3 Gene

Genomics for MXD3 Gene

Regulatory Elements for MXD3 Gene

Enhancers for MXD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F177377 1.1 Ensembl ENCODE 22.4 -66.3 -66310 2.2 HDGF ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 RGS14 MXD3 HNRNPAB PFN3 GRK6 F12 LMAN2 ZNF346 DDX41 FAF2
GH05F177308 0.6 ENCODE 18.4 +1.8 1764 4.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS MXD3 RGS14 RAB24 TSPAN17 GPRIN1 PIR37372
GH05F176386 1.2 ENCODE 18.4 +924.3 924335 4.1 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 FAF2 ENSG00000251414 HIGD2A ENSG00000250909 RPL21P60 MXD3 ZNF346 ZNF346-IT1 PRMT1P1 CLTB
GH05F177356 0.7 ENCODE 17.9 -45.7 -45734 3.7 HDGF TBP SIN3A BMI1 RAD21 ZBTB40 YY1 ELK1 ZNF143 ETV6 RGS14 MXD3 SLC34A1 PRELID1 RAB24
GH05F177360 1 FANTOM5 ENCODE 17.1 -49.7 -49700 3.2 HDGF ATF1 PKNOX1 ARNT SIN3A FEZF1 DMAP1 ZNF48 ZNF2 GLIS2 RGS14 RAB24 MXD3 PFN3 GRK6 F12 PRELID1 DBN1 DOK3 SLC34A1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MXD3 on UCSC Golden Path with GeneCards custom track

Promoters for MXD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297821 757 1601 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 GLIS2 ELK1 ZNF143

Genomic Location for MXD3 Gene

Chromosome:
5
Start:
177,301,461 bp from pter
End:
177,312,757 bp from pter
Size:
11,297 bases
Orientation:
Minus strand

Genomic View for MXD3 Gene

Genes around MXD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MXD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXD3 Gene

Proteins for MXD3 Gene

  • Protein details for MXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW11-MAD3_HUMAN
    Recommended name:
    Max dimerization protein 3
    Protein Accession:
    Q9BW11
    Secondary Accessions:
    • B4E0J1
    • Q53HK1
    • Q7Z4Y0
    • Q8NDJ7
    • Q96ME3

    Protein attributes for MXD3 Gene

    Size:
    206 amino acids
    Molecular mass:
    23477 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).

    Alternative splice isoforms for MXD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MXD3 Gene

Post-translational modifications for MXD3 Gene

  • Ubiquitination at Lys 81 and Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for MXD3 Gene

No data available for DME Specific Peptides for MXD3 Gene

Domains & Families for MXD3 Gene

Protein Domains for MXD3 Gene

Suggested Antigen Peptide Sequences for MXD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BW11

UniProtKB/Swiss-Prot:

MAD3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MXD3: view

Function for MXD3 Gene

Molecular function for MXD3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Gene Ontology (GO) - Molecular Function for MXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MXD3: view
genes like me logo Genes that share phenotypes with MXD3: view

Animal Models for MXD3 Gene

MGI Knock Outs for MXD3:

Animal Model Products

miRNA for MXD3 Gene

miRTarBase miRNAs that target MXD3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MXD3 Gene

Localization for MXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MXD3 Gene COMPARTMENTS Subcellular localization image for MXD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MXD3: view

Pathways & Interactions for MXD3 Gene

SuperPathways for MXD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MXD3: view

No data available for Pathways by source and SIGNOR curated interactions for MXD3 Gene

Transcripts for MXD3 Gene

Unigene Clusters for MXD3 Gene

MAX dimerization protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MXD3 Gene

No ASD Table

Relevant External Links for MXD3 Gene

GeneLoc Exon Structure for
MXD3
ECgene alternative splicing isoforms for
MXD3

Expression for MXD3 Gene

mRNA expression in normal human tissues for MXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MXD3 Gene

This gene is overexpressed in Whole Blood (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of MXD3 Gene:

MXD3

SOURCE GeneReport for Unigene cluster for MXD3 Gene:

Hs.743332
genes like me logo Genes that share expression patterns with MXD3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MXD3 Gene

Orthologs for MXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MXD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MXD3 34 35
  • 89.97 (n)
chimpanzee
(Pan troglodytes)
Mammalia MXD3 34 35
  • 89.33 (n)
dog
(Canis familiaris)
Mammalia MXD3 34 35
  • 87.7 (n)
mouse
(Mus musculus)
Mammalia Mxd3 34 16 35
  • 84.79 (n)
rat
(Rattus norvegicus)
Mammalia Mxd3 34
  • 82.36 (n)
oppossum
(Monodelphis domestica)
Mammalia MXD3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MXD3 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXD3 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mxd3 34
  • 58.96 (n)
zebrafish
(Danio rerio)
Actinopterygii mxd3 34 35
  • 60.5 (n)
worm
(Caenorhabditis elegans)
Secernentea mdl-1 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 35
  • 32 (a)
OneToMany
Species where no ortholog for MXD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MXD3 Gene

ENSEMBL:
Gene Tree for MXD3 (if available)
TreeFam:
Gene Tree for MXD3 (if available)

Paralogs for MXD3 Gene

Paralogs for MXD3 Gene

(4) SIMAP similar genes for MXD3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MXD3: view

Variants for MXD3 Gene

Sequence variations from dbSNP and Humsavar for MXD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10051822 -- 177,308,186(+) GGGGT(G/T)GGGGG intron-variant
rs10587485 -- 177,310,991(+) GAAAC(-/AG)ATGTT intron-variant
rs111251222 -- 177,308,611(+) CAGGT(A/G)ATCCG intron-variant
rs111655533 -- 177,306,519(+) GACCT(C/T)GCCAG reference, synonymous-codon, utr-variant-3-prime
rs111731523 -- 177,311,328(+) CGACC(A/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MXD3 Gene

Variant ID Type Subtype PubMed ID
esv2759396 CNV gain 17122850
nsv1161311 CNV duplication 26073780
nsv428132 CNV gain 18775914
nsv471057 CNV loss 18288195
nsv509103 CNV insertion 20534489
nsv600364 CNV loss 21841781
nsv980764 CNV duplication 23825009

Variation tolerance for MXD3 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MXD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXD3 Gene

Disorders for MXD3 Gene

Relevant External Links for MXD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MXD3

No disorders were found for MXD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXD3 Gene

Publications for MXD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PMID: 10918583) Meroni G. … Reymond A. (Oncogene 2000) 3 22 64
  4. Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. (PMID: 25554682) Barisone G.A. … DI^az E. (Blood Cells Mol. Dis. 2015) 3 64
  5. MXD3 regulation of DAOY cell proliferation dictated by time course of activation. (PMID: 25053245) Ngo T. … DI^az E. (BMC Cell Biol. 2014) 3 64

Products for MXD3 Gene

Sources for MXD3 Gene

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