Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MXD3 Gene

protein-coding GIFtS: 51
GCID: GC05M176732

MAX dimerization protein 3

Explore 4 diseases affiliated with
MXD3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MAX Dimerization Protein 3¹ ²		BHLHC13² ³
MAD3¹ ² ³ ⁵		Max-Associated Protein 3² ³
BHLHc13¹		Max-Interacting Transcriptional Repressor MAD3² ³
Class C Basic Helix-Loop-Helix Protein 13² ³		MYX²
Max Dimerizer 3² ³		Myx³

External Ids:	HGNC: 14008¹	Entrez Gene: 83463²	Ensembl: ENSG00000213347⁷	OMIM: 609450⁵	UniProtKB: Q9BW11³

Export aliases for MXD3 gene to outside databases

Previous GC identifers: GC05M177575 GC05M176668 GC05M176713 GC05M176715 GC05M176665 GC05M176666 GC05M171653

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MXD3:

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators.

The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters

of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled

cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been

described.(provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11

Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which

recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and

suppresses MYC dependent cell transformation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MXD3 gene promoter:
HOXA9B HOXA9 NRSF form 1 NRSF form 2 Meis-1b Gfi-1 HEN1 deltaCREB ARP-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MXD3 promoter sequence

Search SABiosciences Chromatin IP Primers for MXD3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3

MXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXD3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M176732: view genomic region (about GC identifiers)

Start:	176,728,462 bp from pter	End:	176,739,758 bp from pter
Size:	11,297 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11 (See protein sequence)

Recommended Name: Max dimerization protein 3

Size: 206 amino acids; 23477 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q53HK1 Q7Z4Y0 Q8NDJ7 Q96ME3

Alternative splicing: 3 isoforms: Q9BW11-1 Q9BW11-2 Q9BW11-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MXD3: NX_Q9BW11

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BW11

MXD3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136407.1 NP_112590.1

ENSEMBL proteins:

ENSP00000416921 ENSP00000389716 ENSP00000401867 ENSP00000421463 ENSP00000427104

ENSP00000425029

Human Recombinant Protein Products for MXD3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MXD3 OriGene Protein Over-expression Lysate (see all 2): MXD3 OriGene Custom Protein Services for MXD3
	GenScript Custom Purified and Recombinant Proteins Services for MXD3
	Novus Biologicals MXD3 Protein Novus Biologicals MXD3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MXD3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

MXD3 for ontologies About GeneDecksing

MXD3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: MXD3 OriGene Custom Antibody Services for MXD3
	GenScript Custom Superior Antibodies Services for MXD3
	Novus Biologicals MXD3 Antibodies
	Abcam antibodies for MXD3
	Uscn Antibodies for MXD3
	ThermoFisher Antibodies for MXD3

Assay Products for MXD3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MXD3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MXD3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MXD3 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q9BW11

ProtoNet protein and cluster: Q9BW11

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MAD3_HUMAN, Q9BW11

Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which

recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and

suppresses MYC dependent cell transformation (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	--	--
GO:0046983	protein dimerization activity	IEA	--

MXD3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MXD3:

Increased HPV18 LCR reporter a

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mxd3):

cellular

MXD3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mxd3^tm1Rne for MXD3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MXD3

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MXD3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MXD3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MXD3 (see all 15):
		hsa-miR-653 hsa-miR-429 hsa-miR-516b hsa-miR-516b* hsa-miR-3647-3p hsa-miR-583 hsa-miR-151-3p hsa-miR-200c

		SwitchGear 3'UTR luciferase reporter plasmid: MXD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MXD3 (see all 7) OriGene shRNA RFP: MXD3 OriGene siRNA: MXD3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXD3
		Sirion Biotech Custom design and validation of potent shRNA sequences against MXD3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MXD3
			Sirion Biotech Customized adenovirus for overexpression of MXD3 Sirion Biotech Customized adenovirus for potent knockdown of MXD3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MXD3 (NM_031300)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXD3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MXD3
		LifeMap BioReagents: cell line associated with MXD3: PureStem ES-210, Ecto-ntu Progenitor
		Sirion Biotech Customized stable knockdown cell line services for MXD3 Sirion Biotech Customized inducible knockdown cell line services for MXD3 Sirion Biotech Customized stable overexpressing cell line services for MXD3 Sirion Biotech Customized inducible overexpressing cell line services for MXD3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MXD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/21 Interacting proteins for MXD3 (Q9BW11^{2, 3} ENSP00000401867⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAGEA11	P43364²^,³, ENSP00000347358⁴	MINT-66179 I2D: score=5 STRING: ENSP00000347358
MAX	P61244³, ENSP00000351490⁴	I2D: score=4 STRING: ENSP00000351490
SMC3	Q9UQE7³, ENSP00000354720⁴	I2D: score=2 STRING: ENSP00000354720
SIN3A	Q96ST3³, ENSP00000353622⁴	I2D: score=1 STRING: ENSP00000353622
NFKBIA	ENSP00000216797⁴	STRING: ENSP00000216797

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0045892	negative regulation of transcription, DNA-dependent	IEA	--

MXD3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MXD3
Search CenterWatch for drugs/clinical trials and news about MXD3 / MAD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MXD3 gene (2 alternative transcripts):

NM_001142935.1 NM_031300.3

Unigene Cluster for MXD3:

MAX dimerization protein 3

Hs.743332 [show with all ESTs]

Unigene Representative Sequence: NM_001142935

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000503473 ENST00000509339 ENST00000427908(uc010jkk.2) ENST00000423571(uc003mga.3)

ENST00000439742(uc003mgb.2) ENST00000503782 ENST00000513063 ENST00000513169

ENST00000502529

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MXD3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MXD3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MXD3 (see all 15):
		hsa-miR-653 hsa-miR-429 hsa-miR-516b hsa-miR-516b* hsa-miR-3647-3p hsa-miR-583 hsa-miR-151-3p hsa-miR-200c

		SwitchGear 3'UTR luciferase reporter plasmid: MXD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MXD3 (see all 7) OriGene shRNA RFP: MXD3 OriGene siRNA: MXD3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXD3
		Sirion Biotech Custom design and validation of potent shRNA sequences against MXD3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MXD3 (NM_031300)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MXD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXD3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MXD3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MXD3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXD3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXD3

Additional cDNA sequence:

AF114834.1 AK057034.1 AK222579.1 AK316468.1 AL833959.1 BC000745.2

15 DOTS entries:

DT.100680449 DT.100680453 DT.95234582 DT.100059564 DT.100680445 DT.120865263 DT.111589 DT.100674197

DT.100665249 DT.92421358 DT.100059563 DT.100869575 DT.40275632 DT.91678529 DT.95151499

24/709 AceView cDNA sequences (see all 709):

CA748464 CR592574 CR608115 BM314590 AL833959 BQ687476 BM695015 BM914019

BI753944 BU194284 BM699946 AA160502 CR615395 BU738207 BQ650403 BU859230

NM_031300 CB120763 BX437969 AI923956 CB142233 CR593369 BQ773304 BI059722

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MXD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTATGCGTC

About this image

MXD3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MXD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MXD3

SOURCE GeneReport for Unigene cluster: Hs.743332

SABiosciences Custom PCR Arrays for MXD3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MXD3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MXD3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXD3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXD3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MXD3 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mxd3^{1 , 5}	Max dimerization protein 3^{1, 5}	84.79(n)¹ 83.98(a)¹		13 (29.80 cM)⁵ 17121¹ NM_016662.4¹ NP_057871.2¹ 55325168⁵
lizard (Anolis carolinensis)	Reptilia	MXD3⁶	--	58(a)	1 ↔ 1	2(145447702-145457718)
zebrafish (Danio rerio)	Actinopterygii	mxd3¹	MAX dimerization protein 3	61.5(n) 57.5(a)		394031 NM_201056.1 NP_957350.1
honey bee (Apis mellifera)	Insecta	-- --	--	50(a) 49(a)	possible ortholog many → 1	GroupUn.3076(4691-4804) Group15.19(43588-54079)
worm (Caenorhabditis elegans)	Secernentea	mdl-1⁶	MAD-Like family member (mdl-1)	21(a)	possible ortholog	X(6742354-6743863)

ENSEMBL Gene Tree for MXD3 (if available)
TreeFam Gene Tree for MXD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MXD3 gene

MXI1² MXD1² MXD4²

4 SIMAP similar genes for MXD3 using alignment to 5 protein entries: MAD3_HUMAN (see all proteins):

MXD1 MXD4 MXI1 FLJ00110

MXD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184284188^1,2		--	176734579(+)	`CCTGGC/GTGAGG`	2	--	int¹ ut3¹		0	--	--	--	--
rs140600459^1,2	C,F	--	176734647(+)	`AGCCCC/TGCAGC`	3	Q R	int¹ mis¹		2		NA EU	5625
rs72813183^1,2	C	--	176734648(+)	`GCCCCA/GCAGCA`	3	R W	int¹ mis¹		0	--	--	--	--
rs113162836^1,2	C,F	--	176734657(+)	`CAGCTC/TGGCCT`	3	K E	mis¹ int¹		2		NA EU	5657
rs202101084^1,2		--	176734793(+)	`CTGAGA/TCTGAG`	4	D V	mis¹		0	--	--	--	--
rs149939805^1,2	F	--	176734837(+)	`TCCGCC/TCGCAG`	4	R	syn¹		1		NA	2950
rs4568379^1,2	C,F,H	--	176734855(+)	`CGCTCG/CGCCGC`	4	/A	syn¹		11		NS EA NA CSA WA EU	874
rs35691394^1,2	C,F	--	176734945(-)	`GAGCAG/TCGGGC`	4	Q H	mis¹		2		NA WA	196
rs181836323^1,2		--	176734969(+)	`TTCTGC/TGGATC`	2	--	int¹		0	--	--	--	--
rs113998938^1,2	C,F	--	176735005(+)	`GCGGCG/ATGGGG`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MXD3 (176728462 - 176739758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MXD3
2 CNVs: 3589 30224

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MXD3

DNA2.0 Custom Variant and Variant Library Synthesis for MXD3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MXD3 for disorders           About GeneDecksing

OMIM gene information: 609450    OMIM disorders: --

4 diseases for MXD3:    About MalaCards

myxedema cowpox pharyngitis neuronitis

Export disorders for MXD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MXD3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MXD3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PubMed id 10918583)^{1, 9} Meroni G....Reymond A. (2000)
Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)¹ Tang W....Folsom A.R. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
From cerebellar proliferation to tumorigenesis: new insights into the role of Mad3. (PubMed id 18235219)¹ Barisone G.A....Diaz E. (2008)
A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation. (PubMed id 17893326)¹ Yun J.S....Diaz E. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The MAX-interacting transcription factor network. (PubMed id 16908182)¹ Hurlin P.J. and Huang J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83463	HGNC: 14008	AceView: LMAN2andMXD3andRAB24	Ensembl:ENSG00000213347	euGenes: HUgn83463
ECgene: MXD3	H-InvDB: MXD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MXD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MXD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MXD3 gene:
Search GeneIP for patents involving MXD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for MXD3		OriGene shRNA RFP for MXD3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MXD3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MXD3
	OriGene Protein Over-expression Lysate for MXD3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MXD3		OriGene 3'-UTR Clone for MXD3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MXD3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MXD3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MXD3		OriGene Custom Protein Services for MXD3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MXD3
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MXD3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MXD3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MXD3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MXD3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MXD3

	GenScript Custom Purified and Recombinant Proteins Services for MXD3		GenScript cDNA clones with any tag delivered in your preferred vector for MXD3
	GenScript Custom Assay Services for MXD3		GenScript Custom Superior Antibodies Services for MXD3
	GenScript Custom overexpressing Cell Line Services for MXD3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MXD3 promoter
	Search Chromatin IP Primers for MXD3
	RT² qPCR Primer Assay in human, mouse, rat MXD3
	GNC Network for MXD3
	SABiosciences Custom PCR Arrays for MXD3

Search Tocris compounds for MXD3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MXD3 antibodies
	MXD3 proteins
	MXD3 lysates

	Antibodies for MXD3
	See all of Abcam's Antibodies, Kits and Proteins for MXD3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MXD3 Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with MXD3: PureStem ES-210, Ecto-ntu Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD3

	SwitchGear 3'UTR luciferase reporter plasmids for MXD3
	SwitchGear Promoter luciferase reporter plasmids for MXD3

ThermoFisher Antibodies for MXD3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MXD3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MXD3

Sirion Biotech Customized:

	stable knockdown cell line services for MXD3
	inducible knockdown cell line services for MXD3
	design and validation of potent shRNA sequences against MXD3
	adenovirus for potent knockdown of MXD3
	adenovirus for overexpression of MXD3
	stable overexpressing cell line services for MXD3
	inducible overexpressing cell line services for MXD3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MXD3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MXD3 Gene

MAX dimerization protein 3

Aliases
for MXD3 gene

Summaries
for MXD3 gene

Genomic Views
for MXD3 gene

Proteins
for MXD3 gene

Protein Domains /
Families
for MXD3 gene

Function
for MXD3 gene

Pathways & Interactions
for MXD3 gene

Drugs & Compounds
for MXD3 gene

Transcripts
for MXD3 gene

Expression
for MXD3 gene

Orthologs
for MXD3 gene

Paralogs
for MXD3 gene

Genomic Variants
for MXD3 gene

Disorders / Diseases
for MXD3 gene

Publications
for MXD3 gene

External Searches for MXD3 gene

Genome Databases showing MXD3 gene

Other Databases showing MXD3 gene

Specialized Databases showing MXD3 gene

Intellectual Property
for MXD3 gene

Products
for MXD3 gene

View Random Gene

Advanced Search

Export list of displayed genes

MXD3 Gene

MAX dimerization protein 3

Aliasesfor MXD3 gene

Summariesfor MXD3 gene

Genomic Viewsfor MXD3 gene

Proteinsfor MXD3 gene

Protein Domains /Familiesfor MXD3 gene

Functionfor MXD3 gene

Pathways & Interactionsfor MXD3 gene

Drugs & Compoundsfor MXD3 gene

Transcriptsfor MXD3 gene

Expression for MXD3 gene

Orthologsfor MXD3 gene

Paralogsfor MXD3 gene

Genomic Variantsfor MXD3 gene

Disorders / Diseasesfor MXD3 gene

Publicationsfor MXD3 gene

External Searches for MXD3 gene

Genome Databases showing MXD3 gene

Other Databases showing MXD3 gene

Specialized Databases showing MXD3 gene

Intellectual Propertyfor MXD3 gene

Productsfor MXD3 gene

View Random Gene

Aliases
for MXD3 gene

Summaries
for MXD3 gene

Genomic Views
for MXD3 gene

Proteins
for MXD3 gene

Protein Domains /
Families
for MXD3 gene

Function
for MXD3 gene

Pathways & Interactions
for MXD3 gene

Drugs & Compounds
for MXD3 gene

Transcripts
for MXD3 gene

Expression
for MXD3 gene

Orthologs
for MXD3 gene

Paralogs
for MXD3 gene

Genomic Variants
for MXD3 gene

Disorders / Diseases
for MXD3 gene

Publications
for MXD3 gene

Intellectual Property
for MXD3 gene

Products
for MXD3 gene