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MXD3 Gene

protein-coding   GIFtS: 50
GCID: GC05M176744

MAX Dimerization Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAX Dimerization Protein 31 2     Max-Associated Protein 32 3
MAD32 3 5     Max-Interacting Transcriptional Repressor MAD32 3
Class C Basic Helix-Loop-Helix Protein 132 3     MYX2
Max Dimerizer 32 3     Myx3
BHLHC132 3     bHLHc133

External Ids:    HGNC: 140081   Entrez Gene: 834632   Ensembl: ENSG000002133477   OMIM: 6094505   UniProtKB: Q9BW113   

Export aliases for MXD3 gene to outside databases

Previous GC identifers: GC05M177575 GC05M176668 GC05M176713 GC05M176715 GC05M176665 GC05M176666 GC05M176732 GC05M171653 GC05M176733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MXD3 Gene:
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional
regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs
in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is
associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding
different isoforms have been described.(provided by RefSeq, Dec 2008)

GeneCards Summary for MXD3 Gene:
MXD3 (MAX dimerization protein 3) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXI1.

UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
suppresses MYC dependent cell transformation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MXD3 gene promoter:
         HOXA9B   HOXA9   NRSF form 1   NRSF form 2   Meis-1b   Gfi-1   HEN1   deltaCREB   ARP-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMXD3 promoter sequence
   Search Chromatin IP Primers for MXD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MXD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

MXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MXD3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176744:  view genomic region     (about GC identifiers)

Start:
176,728,462 bp from pter      End:
176,739,758 bp from pter
Size:
11,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11 (See protein sequence)
Recommended Name: Max dimerization protein 3  
Size: 206 amino acids; 23477 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity)
Secondary accessions: Q53HK1 Q7Z4Y0 Q8NDJ7 Q96ME3
Alternative splicing: 3 isoforms:  Q9BW11-1   Q9BW11-2   Q9BW11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MXD3: NX_Q9BW11

Explore proteomics data for MXD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys81, Lys108
  • Modification sites at PhosphoSitePlus

  • See MXD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136407.1  NP_112590.1  

    ENSEMBL proteins: 
     ENSP00000416921   ENSP00000389716   ENSP00000401867   ENSP00000421463   ENSP00000427104  
     ENSP00000425029  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MXD: MAX dimerization proteins
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9BW11

    ProtoNet protein and cluster: Q9BW11

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MAD3_HUMAN, Q9BW11
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MXD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAD3_HUMAN, Q9BW11
    Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which
    recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and
    suppresses MYC dependent cell transformation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with MXD3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MXD3:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mxd3):
     cellular 

    Find genes that share phenotypes with MXD3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mxd3tm1Rne for MXD3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MXD3
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    miRNA
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    miRTarBase miRNAs that target MXD3:
    hsa-mir-18a-5p (MIRT050655)

    Block miRNA regulation of human, mouse, rat MXD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MXD3 (see all 15):
    hsa-miR-653 hsa-miR-429 hsa-miR-516b hsa-miR-516b* hsa-miR-3647-3p hsa-miR-583 hsa-miR-151-3p hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidMXD3 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MXD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAD3_HUMAN, Q9BW11: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MXD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MXD3
    Interactions:

        GeneGlobe Interaction Network for MXD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for MXD3 (Q9BW112, 3 ENSP000004018674) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-66179 I2D: score=5 STRING: ENSP00000347358
    MAXP612443, ENSP000003514904I2D: score=4 STRING: ENSP00000351490
    SMC3Q9UQE73, ENSP000003547204I2D: score=2 STRING: ENSP00000354720
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    NFKBIAENSP000002167974STRING: ENSP00000216797
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with MXD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MXD3 (MAD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MXD3 gene (2 alternative transcripts): 
    NM_001142935.1  NM_031300.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503473 ENST00000509339 ENST00000427908(uc010jkk.2) ENST00000423571(uc003mga.3)
    ENST00000439742(uc003mgb.2) ENST00000503782 ENST00000513063 ENST00000513169
    ENST00000502529
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MXD3 (see all 15):
    hsa-miR-653 hsa-miR-429 hsa-miR-516b hsa-miR-516b* hsa-miR-3647-3p hsa-miR-583 hsa-miR-151-3p hsa-miR-200c
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for MXD3
    OriGene qSTAR qPCR primer pairs in human, mouse for MXD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MXD3
      QuantiTect SYBR Green Assays in human, mouse, rat MXD3
      QuantiFast Probe-based Assays in human, mouse, rat MXD3

    Selected AceView cDNA sequences (see all 709):

    CB142233 BQ675140 BU163660 BU738207 CA487181 BG477589 BC015534 CA426541 
    BC017263 CB123986 CR600280 BI059722 BE550886 BF970773 BF917592 CF243162 
    BU507928 CF128796 BI759989 BU194284 CR597078 BQ686293 BU633151 BQ448329 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MXD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATGCGTC
    MXD3 Expression
    About this image


    MXD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    MXD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MXD3 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MXD3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mxd31 , 5 Max dimerization protein 31, 5 84.79(n)1
    83.98(a)1
      13 (29.80 cM)5
    171211  NM_016662.41  NP_057871.21 
     553251685 
    chicken
    (Gallus gallus)
    Aves MXD36
    MAX dimerization protein 3
    50(a)
    1 ↔ 1
    13(9528623-9529772)
    lizard
    (Anolis carolinensis)
    Reptilia MXD36
    MAX dimerization protein 3
    59(a)
    1 ↔ 1
    2(145447702-145457718)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mxd31 MAX dimerization protein 3 58.96(n)
    63.82(a)
      550053  NM_001017299.2  NP_001017299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mxd31 MAX dimerization protein 3 60.5(n)
    56(a)
      394031  NM_201056.1  NP_957350.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdl-16
    Protein MDL-1 (mdl-1) mRNA, complete cds
    23(a)
    1 → many
    X(6742393-6743902) WBGene00003163


    ENSEMBL Gene Tree for MXD3 (if available)
    TreeFam Gene Tree for MXD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MXD3 gene
    MXI12  MXD12  MXD42  
    4 SIMAP similar genes for MXD3 using alignment to 5 protein entries:     MAD3_HUMAN (see all proteins):
    MXD1    MXD4    MXI1    FLJ00110

    Find genes that share paralogs with MXD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MXD3 (see all 173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842841881,2
    --176734579(+) CCTGGC/GTGAGG 2 -- ut31 int10--------
    rs1406004591,2
    C,F--176734647(+) AGCCCC/TGCAGC 3 Q R mis1 int12Minor allele frequency- T:0.00NA EU 5625
    rs728131831,2
    C--176734648(+) GCCCCA/GCAGCA 3 R W mis1 int10--------
    rs1131628361,2
    C,F--176734657(+) CAGCTC/TGGCCT 3 K E mis1 int12Minor allele frequency- T:0.02NA EU 5657
    rs2021010841,2
    --176734793(+) CTGAGA/TCTGAG 4 D V mis10--------
    rs2016260341,2
    C--176734811(+) AGGAGA/GGGCCT 4 P L mis11Minor allele frequency- G:0.00EU 719
    rs1499398051,2
    F--176734837(+) TCCGCC/TCGCAG 4 R syn11Minor allele frequency- T:0.00NA 2950
    rs45683791,2
    C,F,H--176734855(+) CGCTCG/CGCCGC 4 /A syn111Minor allele frequency- C:0.23NS EA NA CSA WA EU 874
    rs2014271191,2
    C--176734892(+) GCTGCC/TGCTGC 4 Q R mis10--------
    rs356913941,2,,4
    C,F--176734945(-) GAGCAG/TCGGGC 4 Q H mis12Minor allele frequency- T:0.02NA WA 196

    HapMap Linkage Disequilibrium report for MXD3 (176728462 - 176739758 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MXD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509103CNV Insertion20534489
    nsv471057CNV Loss18288195
    nsv883159CNV Loss21882294
    dgv6379n71CNV Loss21882294
    nsv428132CNV Gain18775914
    dgv1878e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609450    OMIM disorders: --


    Find genes that share disorders with MXD3           About GenesLikeMe


    Export disorders for MXD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MXD3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MXD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PubMed id 10918583)1, 9 Meroni G....Reymond A. (Oncogene 2000)
    4. Role of MXD3 in proliferation of DAOY human medulloblastoma cells. (PubMed id 22808009)1 Barisone G.A....DA-az E. (PLoS ONE 2012)
    5. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (Am. J. Hum. Genet. 2012)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. From cerebellar proliferation to tumorigenesis: new insights into the role of Mad3. (PubMed id 18235219)1 Barisone G.A....DA-az E. (Cell Cycle 2008)
    10. A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation. (PubMed id 17893326)1 Yun J.S....DA-az E. (Mol. Cell. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83463 HGNC: 14008 AceView: LMAN2andMXD3andRAB24 Ensembl:ENSG00000213347 euGenes: HUgn83463
    ECgene: MXD3 H-InvDB: MXD3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MXD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MXD3 gene:
    Search GeneIP for patents involving MXD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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