Aliases for MXD1 Gene
External Ids for MXD1 Gene
Previous HGNC Symbols for MXD1 Gene
Previous GeneCards Identifiers for MXD1 Gene
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MXD1 Gene
MXD1 (MAX Dimerization Protein 1) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Signaling events mediated by HDAC Class I. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MXI1.
UniProtKB/Swiss-Prot for MXD1 Gene
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MAD thus antagonizes MYC transcriptional activity by competing for MAX.