Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MX2 Gene

Aliases for MX2 Gene

  • MX Dynamin-Like GTPase 2 2 3
  • Interferon-Regulated Resistance GTP-Binding Protein MXB 2 3
  • Second Interferon-Induced Protein P78 2 3
  • Myxovirus Resistance Protein 2 3 4
  • P78-Related Protein 3 4
  • Interferon-Regulated Resistance GTP-Binding Protein MxB 4
  • Myxovirus (Influenza) Resistance 2, Homolog Of Murine 2
  • Myxovirus (Influenza Virus) Resistance 2 (Mouse) 2
  • Interferon-Induced GTP-Binding Protein Mx2 3
  • Myxovirus (Influenza Virus) Resistance 2 3
  • MXB 3

External Ids for MX2 Gene

Previous GeneCards Identifiers for MX2 Gene

  • GC21P039307
  • GC21P041654
  • GC21P041655
  • GC21P042734
  • GC21P028202

Summaries for MX2 Gene

Entrez Gene Summary for MX2 Gene

  • The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for MX2 Gene

MX2 (MX Dynamin-Like GTPase 2) is a Protein Coding gene. Diseases associated with MX2 include croup and influenza. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MX1.

UniProtKB/Swiss-Prot for MX2 Gene

  • Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

Gene Wiki entry for MX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MX2 Gene

Genomics for MX2 Gene

Regulatory Elements for MX2 Gene

Genomic Location for MX2 Gene

Start:
41,361,943 bp from pter
End:
41,409,390 bp from pter
Size:
47,448 bases
Orientation:
Plus strand

Genomic View for MX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MX2 Gene

Proteins for MX2 Gene

  • Protein details for MX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20592-MX2_HUMAN
    Recommended name:
    Interferon-induced GTP-binding protein Mx2
    Protein Accession:
    P20592
    Secondary Accessions:
    • B7Z5D3
    • D3DSI7

    Protein attributes for MX2 Gene

    Size:
    715 amino acids
    Molecular mass:
    82089 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MX2 Gene

    Alternative splice isoforms for MX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MX2 Gene

Proteomics data for MX2 Gene at MOPED

Post-translational modifications for MX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MX2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MX2 Gene

Domains for MX2 Gene

Graphical View of Domain Structure for InterPro Entry

P20592

UniProtKB/Swiss-Prot:

MX2_HUMAN :
  • P20592
Domain:
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 GED domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with MX2: view

No data available for Gene Families for MX2 Gene

Function for MX2 Gene

Molecular function for MX2 Gene

GENATLAS Biochemistry: myxovirus (influenza) resistance 2,human murine MX equivalent
UniProtKB/Swiss-Prot Function: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
UniProtKB/Swiss-Prot Induction: By type I and type III interferons.

Gene Ontology (GO) - Molecular Function for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IMP 15184662
genes like me logo Genes that share ontologies with MX2: view
genes like me logo Genes that share phenotypes with MX2: view

miRNA for MX2 Gene

miRTarBase miRNAs that target MX2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MX2 Gene

Localization for MX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MX2 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MX2 Gene COMPARTMENTS Subcellular localization image for MX2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8798556
GO:0005643 nuclear pore IDA 15184662
GO:0005737 cytoplasm TAS 8798556
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MX2: view

Pathways for MX2 Gene

genes like me logo Genes that share pathways with MX2: view

Gene Ontology (GO) - Biological Process for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006952 defense response TAS 8798556
GO:0008152 metabolic process TAS 8798556
GO:0009615 response to virus IDA 24048477
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MX2: view

Transcripts for MX2 Gene

Unigene Clusters for MX2 Gene

Myxovirus (influenza virus) resistance 2 (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: -
SP9:
SP10: - - - - - - - - -
SP11:
SP12:
SP13: - - - - - - - -
SP14: - - - -
SP15:
SP16:

ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -

Relevant External Links for MX2 Gene

GeneLoc Exon Structure for
MX2
ECgene alternative splicing isoforms for
MX2

Expression for MX2 Gene

mRNA expression in normal human tissues for MX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MX2 Gene

This gene is overexpressed in Whole Blood (19.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MX2 Gene

SOURCE GeneReport for Unigene cluster for MX2 Gene Hs.926

genes like me logo Genes that share expressions with MX2: view

No data available for mRNA Expression by UniProt/SwissProt for MX2 Gene

Orthologs for MX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MX2 35
  • 99.21 (n)
  • 98.6 (a)
MX2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MX2 35
  • 79.61 (n)
  • 71.83 (a)
MX2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MX2 35
  • 80.59 (n)
  • 74.4 (a)
MX2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mx1 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MX 36
  • 45 (a)
OneToMany
MX1 35
  • 54.53 (n)
  • 46.82 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mxc 36
  • 49 (a)
ManyToMany
mxe 35
  • 56.86 (n)
  • 52.12 (a)
mxe 36
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta shi 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyn-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for MX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MX2 Gene

ENSEMBL:
Gene Tree for MX2 (if available)
TreeFam:
Gene Tree for MX2 (if available)

Paralogs for MX2 Gene

Paralogs for MX2 Gene

Selected SIMAP similar genes for MX2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for MX2 Gene

genes like me logo Genes that share paralogs with MX2: view

Variants for MX2 Gene

Sequence variations from dbSNP and Humsavar for MX2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs28425 -- 41,372,958(+) gtatg(C/T)caggt intron-variant
rs45430 -- 41,374,154(-) AGGAT(A/G)TGGGA intron-variant
rs77518 -- 41,399,519(+) TCAGC(A/C)ACTCA intron-variant
rs81481 -- 41,399,435(+) ACACG(C/T)CCATC intron-variant
rs116422 -- 41,375,615(+) ctcca(G/T)gtccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MX2 Gene

Variant ID Type Subtype PubMed ID
nsv834102 CNV Loss 17160897
nsv528279 CNV Gain 19592680
nsv187364 CNV Insertion 16902084

Relevant External Links for MX2 Gene

HapMap Linkage Disequilibrium report
MX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MX2 Gene

Disorders for MX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MX2 Gene including...

Search for MX2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MX2 Gene

(2) Novoseek inferred disease relationships for MX2 Gene

Disease -log(P) Hits PubMed IDs
vesicular stomatitis 67.7 4
influenza 56.8 5

Relevant External Links for MX2

Genetic Association Database (GAD)
MX2
Human Genome Epidemiology (HuGE) Navigator
MX2
genes like me logo Genes that share disorders with MX2: view

No data available for UniProtKB/Swiss-Prot for MX2 Gene

Publications for MX2 Gene

  1. Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. (PMID: 8798556) MelAcn K. … Julkunen I. (J. Biol. Chem. 1996) 2 3 23
  2. MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. (PMID: 18517045) Tanaka S. … Honda M. (Sleep 2008) 3 23 48
  3. cDNA structures and regulation of two interferon-induced human Mx proteins. (PMID: 2481229) Aebi M. … Staeheli P. (Mol. Cell. Biol. 1989) 2 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48

Products for MX2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MX2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MX2
    • Block miRNA regulation of MX2 using miScript Target Protectors

    Sources for MX2 Gene

    Back to Top

    Content