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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MX2 Gene

protein-coding   GIFtS: 54
GCID: GC21P042734

Myxovirus (Influenza Virus) Resistance 2 (Mouse)

(Previous names: myxovirus (influenza) resistance 2, homolog of murine)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Myxovirus (Influenza Virus) Resistance 2 (Mouse)1 2     Myxovirus (Influenza) Resistance 2, Homolog Of Murine1
Interferon-Regulated Resistance GTP-Binding Protein MxB1 2 3     Human Interferon-Regulated Resistance GTP-Binding Protein MXB11
Second Interferon-Induced Protein P781 2     MXB2
Myxovirus Resistance Protein 22 3     Interferon-Induced GTP-Binding Protein Mx22
P78-Related Protein2 3     

External Ids:    HGNC: 75331   Entrez Gene: 46002   Ensembl: ENSG000001834867   OMIM: 1478905   UniProtKB: P205923   

Export aliases for MX2 gene to outside databases

Previous GC identifers: GC21P039307 GC21P041654 GC21P041655 GC21P028202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MX2 Gene:
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family
and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin
region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of
the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This
protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus
resistance protein 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for MX2 Gene: 
MX2 (myxovirus (influenza virus) resistance 2 (mouse)) is a protein-coding gene. Diseases associated with MX2 include croup, and influenza, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot: MX2_HUMAN, P20592
Function: May play a role in regulating nucleocytoplasmic transport and cell-cycle progression

Gene Wiki entry for MX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MX2 gene promoter:
         ER-alpha   HFH-3   MEF-2   Pax-2   AP-4   Pax-2a   E47   FOXI1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMX2 promoter sequence

   Search SABiosciences Chromatin IP Primers for MX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
MX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MX2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P042734:   GeneLoc Nature:405,311-319
Start:
42,733,870 bp from pter       28,307,287 bp from centromere
End:
42,781,317 bp from pter 28,354,211 bp from centromere
Size:
47,448 bases 46,925 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: M30818
genomic clones: P265B9 KB447A5


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MX2_HUMAN, P20592 (See protein sequence)
Recommended Name: Interferon-induced GTP-binding protein Mx2  
Size: 715 amino acids; 82089 Da
Subcellular location: Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores
requires GTP-binding
Secondary accessions: D3DSI7

Explore the universe of human proteins at neXtProt for MX2: NX_P20592

Explore proteomics data for MX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20592

  • MX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MX2 Protein Expression
    REFSEQ proteins: NP_002454.1  
    ENSEMBL proteins: 
     ENSP00000333657   ENSP00000393975   ENSP00000389256   ENSP00000411179   ENSP00000410188  
     ENSP00000446017  
    Reactome Protein details: P20592
    Human Recombinant Protein Products for MX2: 
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    Novus Biologicals MX2 Protein
    Novus Biologicals MX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MX2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore IDA15184662
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    MX2 for ontologies           About GeneDecksing



    MX2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for MX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR003130 GED
     IPR020850 GTPase_effector_domain_GED
     IPR022812 Dynamin
     IPR019762 Dynamin_GTPase_CS
     IPR000375 Dynamin_central

    Graphical View of Domain Structure for InterPro Entry P20592

    ProtoNet protein and cluster: P20592

    1 Blocks protein domain: IPB001401 Dynamin

    UniProtKB/Swiss-Prot: MX2_HUMAN, P20592
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain


    MX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MX2_HUMAN, P20592
    Function: May play a role in regulating nucleocytoplasmic transport and cell-cycle progression
    Induction: By type I and type III interferons

         Genatlas biochemistry entry for MX2:
    myxovirus (influenza) resistance 2,human murine MX equivalent

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IMP15184662
         
    MX2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MX2:
     Decreased cilium length  Decreased cilium length after   Increased Hepatitis C virus re  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mx1):
     hematopoietic system  immune system  mortality/aging 

    MX2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MX2 

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for MX2 (see all 6)
        Antiviral mechanism by IFN-stimulated genes
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    ISG15 antiviral mechanism



    MX2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for MX2 (ENSP000003336574) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARENSP000003574594STRING: ENSP00000357459
    EGR1ENSP000002399384STRING: ENSP00000239938
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    ENSG00000223532ENSP000004008424STRING: ENSP00000400842
    ENSG00000228299ENSP000003978674STRING: ENSP00000397867
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8798556
    GO:0006952defense response TAS8798556
    GO:0015031protein transport IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0046822regulation of nucleocytoplasmic transport IMP15184662

    MX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MX2

    Search CenterWatch for drugs/clinical trials and news about MX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MX2 gene: 
    NM_002463.1  

    Unigene Cluster for MX2:

    Myxovirus (influenza virus) resistance 2 (mouse)
    Hs.926  [show with all ESTs]
    Unigene Representative Sequence: AK126107
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330714(uc002yzf.1 uc010gop.1) ENST00000436410 ENST00000435611
    ENST00000494252 ENST00000495892(uc002yze.1) ENST00000416447 ENST00000418103
    ENST00000482953(uc002yzg.1) ENST00000496774 ENST00000493753 ENST00000481838
    ENST00000474368 ENST00000398632 ENST00000543692(uc011aer.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MX2
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    SwitchGear 3'UTR luciferase reporter plasmidMX2 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MX2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MX2

    Additional mRNA sequence: 

    AK122952.1 AK124336.1 AK126107.1 AK127895.1 AK298780.1 AK308060.1 AY312582.1 BC035293.1 
    M30818.1 M33883.1 

    12 DOTS entries:

    DT.312273  DT.101955523  DT.75198101  DT.40125542  DT.97803842  DT.100736218  DT.92450875  DT.100737398 
    DT.121140513  DT.121140524  DT.92450887  DT.75187592 

    24/98 AceView cDNA sequences (see all 98):

    BX114704 AK122952 M33883 BQ880934 NM_002463 AI817128 BQ423116 CA429620 
    BQ420536 AL553484 BC035293 AW001846 CR600045 AK126107 BP368310 BQ678928 
    CD614873 AA811635 AI092941 BU742076 BM853439 CD614869 AA806106 AY312582 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MX2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                    -     -     -     -     -     -     -     -     -                                               -                 -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                        -     -     -                                               -                                       

    ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:                                -     -           -           -                           
    SP2:                                -     -           -           -                           
    SP3:                                -     -                                                   
    SP4:                          -     -     -           -           -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MX2 expression in normal human tissues (normalized intensities)      MX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MX2 Expression
    About this image


    MX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Adipose (Muscoskeletal System)
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Lymph (Hematopoietic System)
             Lymphnode   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Thymus (Hematopoietic System)

    See MX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MX2

    SOURCE GeneReport for Unigene cluster: Hs.926
        SABiosciences Expression via Pathway-Focused PCR Array including MX2: 
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MX2 gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mx15 myxovirus (influenza virus) resistance 1   --   16 (57.46 cM) 97447035 
    chicken
    (Gallus gallus)
    Aves MX6
    interferon-induced GTP-binding protein Mx
    45(a)
    1 → many
    1(108280289-108296301)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    49(a)
    many ↔ many
    many ↔ many
    3(138462835-138488436)
    3(138430803-138440967)
    zebrafish
    (Danio rerio)
    Actinopterygii mxe1 myxovirus (influenza virus) resistance E 56.81(n)
    52.12(a)
      337663  NM_182867.1  NP_878287.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS16
    Dynamin-like GTPase required for vacuolar sorting;...
    23(a)
    1 → many
    XI(440608-442722)


    ENSEMBL Gene Tree for MX2 (if available)
    TreeFam Gene Tree for MX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MX2 gene
    DNM12  DNM22  DNM32  MX12  
    5 SIMAP similar genes for MX2 using alignment to 8 protein entries:     MX2_HUMAN (see all proteins):
    MX1    DNM1    DNM2    DNM3    DNM1L

    MX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MX2
    PGOHUM00000250166


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1291 SNPs in MX2 are shown (see all 1291)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380915841,2
    --42731968(+) TCCACC/TCCAAG 1 -- us2k10--------
    rs1495465651,2
    --42731979(+) GTGCAC/TCCGCT 1 -- us2k10--------
    rs1485482621,2
    C--42732036(+) CTTGT-/CTA   
       CAGCA
    CTTCA
    1 -- us2k10--------
    rs2009465261,2
    C--42732041(-) AAGTGC/TTGTAG 1 -- us2k10--------
    rs4110481,2
    C--42732206(+) GAGGCG/ACTGGC 1 -- us2k13Minor allele frequency- A:0.04NA 124
    rs781818401,2
    F--42732242(+) GGCAGG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1461490051,2
    C--42732247(+) GAGGCA/GGGCAC 1 -- us2k10--------
    rs1388570261,2
    --42732286(+) AAGCTG/TCACAC 1 -- us2k10--------
    rs1882922841,2
    C--42732337(+) CCAGCA/GGCTGT 1 -- us2k10--------
    rs1427964781,2
    C--42732346(+) GTGACC/TGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MX2 (42733870 - 42781317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv187364CNV Insertion16902084
    nsv834102CNV Loss17160897
    nsv528279CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147890    OMIM disorders: --

    11 diseases for MX2:    About MalaCards
    croup    influenza    stomatitis    narcolepsy
    optic atrophy    prostate cancer, progression of    hepatitis c    prostate cancer
    hepatitis    hepatitis b    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MX2:
    Influenza     Croup

    MX2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vesicular stomatitis 67.7 4 1312277 (2), 2161946 (1), 17970694 (1)
    influenza 56.8 6 2161946 (2), 1312277 (2), 9405443 (1)

    Genetic Association Database (GAD): MX2
    Human Genome Epidemiology (HuGE) Navigator: MX2 (6 documents)

    Export disorders for MX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MX2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA structures and regulation of two interferon-induced human Mx proteins. (PubMed id 2481229)1, 2, 3 Aebi M.... Staeheli P. (1989)
    2. MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. (PubMed id 18517045)1, 4, 9 Tanaka S....Honda M. (2008)
    3. Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. (PubMed id 8798556)1, 3, 9 Melen K....Julkunen I. (1996)
    4. Genome-wide association study identifies three new mel anoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (2011)
    5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. (PubMed id 15184662)1, 2 King M.C....Lemmon M.A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    10. Cloning and sequence analyses of cDNAs for interferon- and virus- induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter. (PubMed id 2154602)1, 2 Horisberger M.A....Content J. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4600 HGNC: 7533 AceView: MX2 Ensembl:ENSG00000183486 euGenes: HUgn4600
    ECgene: MX2 H-InvDB: MX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MX2 gene:
    Search GeneIP for patents involving MX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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