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MX2 Gene

protein-coding   GIFtS: 55
GCID: GC21P042734

Myxovirus (Influenza Virus) Resistance 2 (Mouse)

(Previous names: myxovirus (influenza) resistance 2, homolog of murine)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Myxovirus (Influenza Virus) Resistance 2 (Mouse)1 2     Myxovirus (Influenza) Resistance 2, Homolog Of Murine1
Interferon-Regulated Resistance GTP-Binding Protein MxB1 2 3     Human Interferon-Regulated Resistance GTP-Binding Protein MXB11
Second Interferon-Induced Protein P781 2     MXB2
Myxovirus Resistance Protein 22 3     Interferon-Induced GTP-Binding Protein Mx22
P78-Related Protein2 3     

External Ids:    HGNC: 75331   Entrez Gene: 46002   Ensembl: ENSG000001834867   OMIM: 1478905   UniProtKB: P205923   

Export aliases for MX2 gene to outside databases

Previous GC identifers: GC21P039307 GC21P041654 GC21P041655 GC21P028202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MX2 Gene:
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family
and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin
region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of
the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This
protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus
resistance protein 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for MX2 Gene:
MX2 (myxovirus (influenza virus) resistance 2 (mouse)) is a protein-coding gene. Diseases associated with MX2 include croup, and stomatitis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot: MX2_HUMAN, P20592
Function: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency
virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the
HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral
activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic
transport and cell-cycle progression

Gene Wiki entry for MX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MX2 gene promoter:
         ER-alpha   HFH-3   MEF-2   Pax-2   AP-4   Pax-2a   E47   FOXI1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMX2 promoter sequence

   Search Chromatin IP Primers for MX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
MX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MX2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P042734:   GeneLoc Nature:405,311-319
Start:
42,733,870 bp from pter       28,307,287 bp from centromere
End:
42,781,317 bp from pter 28,354,211 bp from centromere
Size:
47,448 bases 46,925 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: M30818
genomic clones: P265B9 KB447A5


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MX2_HUMAN, P20592 (See protein sequence)
Recommended Name: Interferon-induced GTP-binding protein Mx2  
Size: 715 amino acids; 82089 Da
Secondary accessions: D3DSI7

Explore the universe of human proteins at neXtProt for MX2: NX_P20592

Explore proteomics data for MX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002454.1  
    ENSEMBL proteins: 
     ENSP00000333657   ENSP00000393975   ENSP00000389256   ENSP00000411179   ENSP00000410188  
     ENSP00000446017  
    Reactome Protein details: P20592

    MX2 Human Recombinant Protein Products:

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    Novus Biologicals MX2 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MX2

    MX2 Antibody Products:

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    Cloud-Clone Corp. CLIAs for MX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR003130 GED
     IPR020850 GTPase_effector_domain_GED
     IPR022812 Dynamin_SF
     IPR019762 Dynamin_GTPase_CS
     IPR000375 Dynamin_central

    Graphical View of Domain Structure for InterPro Entry P20592

    ProtoNet protein and cluster: P20592

    1 Blocks protein domain: IPB001401 Dynamin

    UniProtKB/Swiss-Prot: MX2_HUMAN, P20592
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain


    MX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MX2_HUMAN, P20592
    Function: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency
    virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the
    HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral
    activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic
    transport and cell-cycle progression
    Induction: By type I and type III interferons

         Genatlas biochemistry entry for MX2:
    myxovirus (influenza) resistance 2,human murine MX equivalent

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IMP15184662
         
    MX2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MX2:
     Decreased cilium length  Decreased cilium length after   Increased Hepatitis C virus re  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mx1):
     hematopoietic system  immune system  mortality/aging 

    MX2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MX2:
    hsa-mir-146a-5p (MIRT021267)

    Block miRNA regulation of human, mouse, rat MX2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MX2
    SwitchGear 3'UTR luciferase reporter plasmidMX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MX2
    Predesigned siRNA for gene silencing in human, mouse, rat MX2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MX2

    Clone
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    OriGene clones in human, mouse for MX2 (see all 7)
    OriGene ORF clones in mouse, rat for MX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MX2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MX2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MX2_HUMAN, P20592: Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores
    requires GTP-binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8798556
    GO:0005643nuclear pore IDA15184662
    GO:0005737cytoplasm TAS8798556
    GO:0005829cytosol TAS--

    MX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MX2
        Interferon alpha/beta signaling
    ISG15 antiviral mechanism



    MX2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MX2: 
              Type I Interferon Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MX2 (ENSP000003336574) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARENSP000003574594STRING: ENSP00000357459
    EGR1ENSP000002399384STRING: ENSP00000239938
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    ENSG00000223532ENSP000004008424STRING: ENSP00000400842
    ENSG00000228299ENSP000003978674STRING: ENSP00000397867
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8798556
    GO:0006952defense response TAS8798556
    GO:0009615response to virus IDA--
    GO:0015031protein transport IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--

    MX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MX2 gene: 
    NM_002463.1  

    Unigene Cluster for MX2:

    Myxovirus (influenza virus) resistance 2 (mouse)
    Hs.926  [show with all ESTs]
    Unigene Representative Sequence: AK126107
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330714(uc002yzf.1 uc010gop.1) ENST00000436410 ENST00000435611
    ENST00000494252 ENST00000495892(uc002yze.1) ENST00000416447 ENST00000418103
    ENST00000482953(uc002yzg.1) ENST00000496774 ENST00000493753 ENST00000481838
    ENST00000474368 ENST00000398632 ENST00000543692(uc011aer.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MX2
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    GenScript Custom all cDNA clones Services for MX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MX2
    Primer
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    OriGene qPCR primer pairs and template standards for MX2
    OriGene qSTAR qPCR primer pairs in human, mouse for MX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MX2
      QuantiTect SYBR Green Assays in human, mouse, rat MX2
      QuantiFast Probe-based Assays in human, mouse, rat MX2

    Additional mRNA sequence: 

    AK122952.1 AK124336.1 AK126107.1 AK127895.1 AK298780.1 AK308060.1 AY312582.1 BC035293.1 
    M30818.1 M33883.1 

    12 DOTS entries:

    DT.312273  DT.101955523  DT.75198101  DT.40125542  DT.97803842  DT.100736218  DT.92450875  DT.100737398 
    DT.121140513  DT.121140524  DT.92450887  DT.75187592 

    Selected AceView cDNA sequences (see all 98):

    M33883 AK126107 M30818 CR600045 AK122952 BM853439 BQ420536 BX114704 
    AY312582 CD614867 AI092941 BQ423116 AL553484 NM_002463 AA455246 AA811635 
    CD614873 BC035293 BQ678928 CA429620 CF529803 BP368310 BP341879 AI817128 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MX2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                    -     -     -     -     -     -     -     -     -                                               -                 -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                        -     -     -                                               -                                       

    ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:                                -     -           -           -                           
    SP2:                                -     -           -           -                           
    SP3:                                -     -                                                   
    SP4:                          -     -     -           -           -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MX2 Expression
    About this image


    MX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
    MX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.926
        Pathway & Disease-focused RT2 Profiler PCR Array including MX2: 
              Type I Interferon Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MX2
    OriGene qSTAR qPCR primer pairs in human, mouse for MX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MX2
    QuantiTect SYBR Green Assays in human, mouse, rat MX2
    QuantiFast Probe-based Assays in human, mouse, rat MX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mx15 myxovirus (influenza virus) resistance 1   --   16 (57.46 cM) 97447035 
    chicken
    (Gallus gallus)
    Aves MX11 myxovirus (influenza virus) resistance 1, interferon-inducible more 54.53(n)
    46.82(a)
      395313  NM_204609.1  NP_989940.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    49(a)
    many ↔ many
    many ↔ many
    3(138462835-138488436)
    3(138430803-138440967)
    zebrafish
    (Danio rerio)
    Actinopterygii mxe1 myxovirus (influenza virus) resistance E 56.86(n)
    52.12(a)
      337663  NM_182867.1  NP_878287.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shi6
    shibire
    18(a)
    1 → many
    X(15786149-15800725)
    worm
    (Caenorhabditis elegans)
    Secernentea dyn-16
    Protein DYN-1, isoform a (dyn-1) mRNA, complete cd...
    21(a)
    1 → many
    X(15568916-15573693) WBGene00001130
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS16
    Dynamin-like GTPase required for vacuolar sorting;...
    25(a)
    1 → many
    XI(440608-442722) YKR001C


    ENSEMBL Gene Tree for MX2 (if available)
    TreeFam Gene Tree for MX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MX2 gene
    DNM12  DNM22  DNM1L2  DNM32  MX12  
    5 SIMAP similar genes for MX2 using alignment to 8 protein entries:     MX2_HUMAN (see all proteins):
    MX1    DNM1    DNM2    DNM3    DNM1L

    MX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MX2
    PGOHUM00000250166


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MX2 (see all 1291)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380915841,2
    --42731968(+) TCCACC/TCCAAG 1 -- us2k10--------
    rs1495465651,2
    --42731979(+) GTGCAC/TCCGCT 1 -- us2k10--------
    rs1485482621,2
    C--42732036(+) CTTGT-/CTA   
       CAGCA
    CTTCA
    1 -- us2k10--------
    rs2009465261,2
    C--42732041(-) AAGTGC/TTGTAG 1 -- us2k10--------
    rs4110481,2
    C--42732206(+) GAGGCG/ACTGGC 1 -- us2k13Minor allele frequency- A:0.04NA 124
    rs781818401,2
    F--42732242(+) GGCAGG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1461490051,2
    C--42732247(+) GAGGCA/GGGCAC 1 -- us2k10--------
    rs1388570261,2
    --42732286(+) AAGCTG/TCACAC 1 -- us2k10--------
    rs1882922841,2
    C--42732337(+) CCAGCA/GGCTGT 1 -- us2k10--------
    rs1427964781,2
    C--42732346(+) GTGACC/TGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MX2 (42733870 - 42781317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv187364CNV Insertion16902084
    nsv834102CNV Loss17160897
    nsv528279CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MX2
    DNA2.0 Custom Variant and Variant Library Synthesis for MX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147890    OMIM disorders: --

    13 diseases for MX2:    
    About MalaCards
    croup    stomatitis    influenza    optic atrophy
    narcolepsy    hepatitis c virus    hepatitis c    prostate cancer
    hepatitis    hepatitis b    prostatitis    multiple sclerosis
    melanoma

    2 diseases from the University of Copenhagen DISEASES database for MX2:
    Influenza     Croup

    MX2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vesicular stomatitis 67.7 4 1312277 (2), 2161946 (1), 17970694 (1)
    influenza 56.8 6 2161946 (2), 1312277 (2), 9405443 (1)

    Genetic Association Database (GAD): MX2
    Human Genome Epidemiology (HuGE) Navigator: MX2 (6 documents)

    Export disorders for MX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MX2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA structures and regulation of two interferon-induced human Mx proteins. (PubMed id 2481229)1, 2, 3 Aebi M.... Staeheli P. (Mol. Cell. Biol. 1989)
    2. MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. (PubMed id 18517045)1, 4, 9 Tanaka S....Honda M. (Sleep 2008)
    3. Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. (PubMed id 8798556)1, 3, 9 MelAcn K....Julkunen I. (J. Biol. Chem. 1996)
    4. MX2 is an interferon-induced inhibitor of HIV-1 infection. (PubMed id 24121441)1, 2 Kane M....Bieniasz P.D. (Nature 2013)
    5. Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. (PubMed id 24048477)1, 2 Goujon C.... Malim M.H. (Nature 2013)
    6. Genome-wide association study identifies three new melanoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (Nat. Genet. 2011)
    7. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. (PubMed id 15184662)1, 2 King M.C.... Lemmon M.A. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4600 HGNC: 7533 AceView: MX2 Ensembl:ENSG00000183486 euGenes: HUgn4600
    ECgene: MX2 H-InvDB: MX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MX2 gene:
    Search GeneIP for patents involving MX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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