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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MX1 Gene

protein-coding GIFtS: 63
GCID: GC21P042792

myxovirus (influenza virus) resistance 1, interferon-inducible...

(Previous names: myxovirus (influenza) resistance 1, homolog of murine (interferon-inducible...)

Explore 73 diseases affiliated with
MX1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 (Mouse)¹ ²		MX² ⁵
IFI-78K¹ ² ³		Myxovirus (Influenza) Resistance 1, Homolog Of Murine (Interferon-Inducible Protein P78)¹
MxA¹ ²		Human Interferon-Regulated Resistance GTP-Binding Protein MXA11
Interferon-Regulated Resistance GTP-Binding Protein MxA² ³		Interferon-Induced GTP-Binding Protein Mx1²
Myxoma Resistance Protein 1² ³		Interferon-Induced Protein P78³
IFI78² ⁵		Myxovirus Resistance Protein 1³

External Ids:	HGNC: 7532¹	Entrez Gene: 4599²	Ensembl: ENSG00000157601⁷	OMIM: 147150⁵	UniProtKB: P20591³

Export aliases for MX1 gene to outside databases

Previous GC identifers: GC21P039372 GC21P041713 GC21P041718 GC21P041720 GC21P028262

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MX1:

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus

infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic

relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a

member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein

have been found for this gene. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591

Function: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some

DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of

their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV)

replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by

sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress.

Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic

of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the

calcium channel activity of TRPCs

Gene Wiki entry for MX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MX1 gene promoter:
CREB AP-1 deltaCREB STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MX1 promoter sequence

Search SABiosciences Chromatin IP Primers for MX1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

MX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MX1 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P042792:	GeneLoc	Nature:405,311-319
Start:	42,792,231 bp from pter	28,371,509 bp from centromere
End:	42,831,141 bp from pter	28,404,533 bp from centromere
Size:	38,911 bases	33,025 bases
Orientation:	plus strand	plus strand

Whole chromosome sequencing:
cDNA sequence:	NM_002462
genomic clones:	KB447A5 to Q87D5

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591 (See protein sequence)

Recommended Name: Interferon-induced GTP-binding protein Mx1

Size: 662 amino acids; 75520 Da

Subunit: Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain.

Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures.

Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B.

Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The

GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N

Subcellular location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Co-localizes with CCHFV

protein N in the perinuclear region

Subcellular location: Isoform 2: Cytoplasm. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells

3 PDB 3D structures from and Proteopedia for MX1:

3LJB (3D)

3SZR (3D)

3ZYS (3D)

Secondary accessions: B2RDA5 B3KU10 C9IYV7 C9J8D6 C9JN19 C9JN88 C9JUL1 C9JZS6 D3DSI8 Q86YP5 Q96CI3

Alternative splicing: 2 isoforms: P20591-1 P20591-2

Explore the universe of human proteins at neXtProt for MX1: NX_P20591

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20591

MX1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138397.1 NP_001171517.1 NP_002453.2

ENSEMBL proteins:

ENSP00000381601 ENSP00000408498 ENSP00000392151 ENSP00000381599 ENSP00000400923

ENSP00000402215 ENSP00000393931 ENSP00000410989 ENSP00000288383 ENSP00000410523

Reactome Protein details: P20591
Human Recombinant Protein Products for MX1:

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	Novus Biologicals MX1 Protein Novus Biologicals MX1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MX1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	TAS	--
GO:0048471	perinuclear region of cytoplasm	IDA	15047845

MX1 for ontologies About GeneDecksing

MX1 Antibody Products:

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	OriGene Antibodies (see all 3): MX1 OriGene Custom Antibody Services for MX1
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	Novus Biologicals MX1 Antibodies
	Abcam antibodies for MX1
	Uscn Antibodies for MX1
	ThermoFisher Antibody for MX1

Assay Products for MX1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MX1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MX1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MX1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003130 GED

IPR001401 Dynamin_GTPase

IPR020850 GTPase_effector_domain_GED

IPR015577 Interferon-induced_Mx

IPR022812 Dynamin

Graphical View of Domain Structure for InterPro Entry P20591

ProtoNet protein and cluster: P20591

1 Blocks protein family: IPB001401 Dynamin

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591

Domain: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition

Domain: The middle domain mediates self-assembly and oligomerization

Similarity: Belongs to the dynamin family

Similarity: Contains 1 GED domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MX1_HUMAN, P20591

Function: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some

DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of

their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV)

replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by

sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress.

Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic

of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the

calcium channel activity of TRPCs

Induction: By type I and type III interferons. Isoform 2 is induced by HSV-1

Genatlas biochemistry entry for MX1:

myxovirus (influenza) resistance 1;human murine MX equivalent

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	15757897
GO:0005525	GTP binding	IEA	--

MX1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for MX1:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MX1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MX1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MX1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MX1
		SwitchGear 3'UTR luciferase reporter plasmid: MX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MX1 (see all 7) OriGene shRNA RFP: MX1 OriGene siRNA: MX1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MX1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MX1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MX1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MX1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MX1 (NM_004097)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MX1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MX1
		Search LifeMap BioReagents cell lines for MX1
		Sirion Biotech Customized stable knockdown cell line services for MX1 Sirion Biotech Customized inducible knockdown cell line services for MX1 Sirion Biotech Customized stable overexpressing cell line services for MX1 Sirion Biotech Customized inducible overexpressing cell line services for MX1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Expression of IFN-induced genes

Expression of IFN-induced genes

1.00

Interferon alpha/beta signaling

0.61

Measles

Measles

1.00

Influenza A

0.35

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

ISG15 antiviral mechanism

0.49

Antiviral mechanism by IFN-stimulated genes

0.49

Immune System

Immune System

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for MX1 (see all 8)

	Antiviral mechanism by IFN-stimulated genes
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Expression of IFN-induced genes
	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18

2 Kegg Pathways (Kegg details for MX1):

	Measles
	Influenza A

MX1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/61 Interacting proteins for MX1 (P20591^{1, 3} ENSP00000381599⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRPC3	Q13507¹^,³, ENSP00000368966⁴	EBI-929476,EBI-520807 I2D: score=3 STRING: ENSP00000368966
TRPC6	Q9Y210¹^,³, ENSP00000340913⁴	EBI-929476,EBI-929362 I2D: score=3 STRING: ENSP00000340913
DAXX	Q9UER7³, ENSP00000396876⁴	I2D: score=2 STRING: ENSP00000396876 STRING: ENSP00000266000
TRPC4	Q9UBN4¹^,³, ENSP00000369003⁴	EBI-929476,EBI-929504 I2D: score=3 STRING: ENSP00000369003
TRPC5	Q9UL62³, ENSP00000262839⁴	I2D: score=3 STRING: ENSP00000262839

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006917	induction of apoptosis	TAS	9389754
GO:0006952	defense response	TAS	2154602
GO:0007165	signal transduction	TAS	9389754
GO:0009615	response to virus	IMP	15047845
GO:0019221	cytokine-mediated signaling pathway	TAS	--

MX1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MX1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MX1
10/21 Novoseek chemical compound relationships for MX1 gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate	89.2	29	9036986 (2), 7861026 (1), 10702714 (1), 15745156 (1) (see all 27)
betaseron	79.2	5	10851362 (2), 19857496 (1), 11516761 (1), 15589054 (1)
avonex	77.2	5	10851362 (2), 16601938 (1), 11516761 (1), 15589054 (1)
rebif	74.5	4	10851362 (2), 16601938 (1), 11516761 (1)
ifn-alpha	71.5	22	9562412 (4), 12595530 (2), 17505473 (2), 17763410 (2) (see all 10)
ribavirin	49.9	3	12210408 (2), 12719586 (1)
gtp	47.1	38	8411374 (4), 11959118 (3), 7507812 (2), 7539430 (2) (see all 15)
poly(i-c)	40.9	4	14698216 (2), 10954913 (1), 16751646 (1)
imiquimod	39.7	6	15769273 (3), 15611427 (1), 16077073 (1), 9367544 (1)
neopterin	24.3	3	12522042 (1), 9858319 (1), 17420930 (1)

Search CenterWatch for drugs/clinical trials and news about MX1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MX1 gene (3 alternative transcripts):

NM_001144925.1 NM_001178046.1 NM_002462.3

Unigene Cluster for MX1:

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

Hs.517307 [show with all ESTs]

Unigene Representative Sequence: AK096355

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000490220 ENST00000468506 ENST00000398600(uc002yzh.3) ENST00000413778

ENST00000419044 ENST00000398598(uc002yzi.3 uc010goq.3) ENST00000424365

ENST00000484465 ENST00000417963 ENST00000441677 ENST00000478268 ENST00000427464

ENST00000288383 ENST00000467510 ENST00000486275 ENST00000491110 ENST00000455164

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MX1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MX1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MX1
		SwitchGear 3'UTR luciferase reporter plasmid: MX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MX1 (see all 7) OriGene shRNA RFP: MX1 OriGene siRNA: MX1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MX1

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		GenScript: all cDNA clones in your preferred vector: MX1 (NM_004097)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MX1

Additional cDNA sequence:

AK093008.1 AK096355.1 AK225885.1 AK315465.1 AY186254.1 BC014222.2 BC032602.1 M30817.1

M33882.1

22 DOTS entries:

DT.97847397 DT.218632 DT.100793266 DT.100793277 DT.92450878 DT.100793270 DT.218633 DT.95121282

DT.100009551 DT.100644751 DT.95276034 DT.100030600 DT.100793267 DT.121129973 DT.95276031 DT.101977467

DT.121129985 DT.92450867 DT.95318508 DT.100754756 DT.75110933 DT.95253378

24/331 AceView cDNA sequences (see all 331):

BQ688620 BQ068247 CA422865 R88402 AU122119 AI968983 CR595895 BQ447080

AU133022 AI379185 AI953746 NM_002462 CB127818 AA425969 AW574807 AU122500

BQ447055 AI865200 BX482492 F05704 AA426260 CA307542 N98766 CD367498

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MX1 (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·
SP1:																																													-				-
SP2:
SP3:																																													-				-
SP4:
SP5:					-

ExUns:	15b	^	16	^	17	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MX1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGCCGTGT

About this image

MX1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MX1

SOURCE GeneReport for Unigene cluster: Hs.517307

SABiosciences Expression via Pathway-Focused PCR Arrays including MX1:

Innate & Adaptive Immune Responses in human mouse rat

Antiviral Response in human mouse rat

Interferons & Receptors in human mouse rat

Type I Interferon Response in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MX1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MX1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MX1

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MX1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MX1¹	myxovirus (influenza virus) resistance 1, interferon-inducible more	56.86(n) 49.13(a)		395313 NM_204609.1 NP_989940.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	55(a) 52(a)	possible ortholog 1 ↔ many	3(138462835-138488436) 3(138430803-138440967)
zebrafish (Danio rerio)	Actinopterygii	mxa²	myxovirus (influenza) resistance A	73.72(n)		360142 AF533769.1
thale cress (Arabidopsis thaliana)	eudicotyledons	DRP4C¹	Dynamin related protein 4C	42.04(n) 28.93(a)		842345 NM_104736.2 NP_176252.1
rice (Oryza sativa)	Liliopsida	Os04g0129900¹	hypothetical protein	47.66(n) 36.21(a)		4335000 NM_001058628.2 NP_001052093.2

ENSEMBL Gene Tree for MX1 (if available)
TreeFam Gene Tree for MX1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MX1 gene

DNM1² MX2² DNM2² DNM3²

4 SIMAP similar genes for MX1 using alignment to 8 protein entries: MX1_HUMAN (see all proteins):

MX2 DNM1L DNM2 DNM3

MX1 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for MX1
PGOHUM00000245457 PGOHUM00000245459 PGOHUM00000245461 PGOHUM00000245462 PGOHUM00000245463

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117251080^1,2		--	42790524(+)	`CTCACC/TGGAGC`	1	--	us2k¹		1		EA	120
rs190957621^1,2		--	42790536(+)	`CCCCTC/TGATCA`	1	--	us2k¹		0	--	--	--	--
rs114543472^1,2		--	42790560(+)	`TAGCAC/TGCGCC`	1	--	us2k¹		1		WA	118
rs114918277^1,2		--	42790577(+)	`TGTGGG/AGTACA`	1	--	us2k¹		1		WA	118
rs182118266^1,2		--	42790656(+)	`CAAGGA/TAAGTT`	1	--	us2k¹		0	--	--	--	--
rs758343^1,2	C,A	--	42790680(+)	`TTTTAT/CTTTTT`	1	--	us2k¹		5		WA CSA NA EA	362
rs143477594^1,2		--	42790802(+)	`AGTAGC/GTGGAA`	1	--	us2k¹		0	--	--	--	--
rs146257247^1,2		--	42790882(+)	`ATGAGA/CTTTTG`	1	--	us2k¹		0	--	--	--	--
rs187881917^1,2		--	42790898(+)	`GCCTAC/TTCGCT`	1	--	us2k¹		0	--	--	--	--
rs79655468^1,2	F	--	42790901(+)	`TATTCG/TCTTCC`	1	--	us2k¹		3		WA NA EA	358

HapMap Linkage Disequilibrium report for MX1 (42792231 - 42831141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MX1: --
Human Gene Mutation Database (HGMD): MX1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MX1 for disorders           About GeneDecksing

OMIM gene information: 147150    OMIM disorders: --

20/73 diseases for MX1 (see all 73):    About MalaCards

influenza crimean-congo hemorrhagic fever rift valley fever subacute sclerosing panencephalitis

myxoma sudden infant death syndrome parainfluenza virus type 3 west nile virus

polymyalgia rheumatica hemorrhagic fever lichen planus common variable immunodeficiency

bell's palsy dengue hemorrhagic fever lupus erythematosus biliary atresia

severe acute respiratory syndrome juvenile myelomonocytic leukemia temporal arteritis alopecia areata

4 diseases from the University of Copenhagen DISEASES database for MX1:

Influenza Multiple sclerosis Breast cancer Hepatitis C

10/58 Novoseek disease relationships for MX1 gene (see all 58) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vesicular stomatitis	80.7	19	2161946 (2), 15812245 (1), 7507812 (1), 9060610 (1) (see all 17)
influenza	70.4	108	18199636 (5), 16704297 (5), 1548781 (5), 1321288 (5) (see all 53)
multiple sclerosis	70.2	22	14607790 (3), 16843495 (2), 11536237 (2), 14529316 (1) (see all 18)
virus infection	69.1	74	12858204 (4), 16704297 (4), 11551256 (4), 9562412 (4) (see all 45)
rna virus infections	65.1	2	7831843 (1)
multiple sclerosis relapsing-remitting	62.2	1	11516761 (1)
rift valley fever	57.2	1	17970694 (1)
lupus erythematosus	55.4	2	10070906 (1), 7822763 (1)
hepatitis c chronic	53.2	5	12210408 (1), 15117331 (1), 15684819 (1), 16894313 (1)
hepatitis c	47.8	14	10213463 (2), 11805446 (2), 10971132 (2), 19635103 (1) (see all 11)

Genetic Association Database (GAD): MX1
Human Genome Epidemiology (HuGE) Navigator: MX1 (26 documents)

Export disorders for MX1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MX1 gene, integrated from 9 sources (see all 387):
(articles sorted by number of sources associating them with MX1)

Utopia: connect your pdf to the dynamic
world of online information

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. (PubMed id 9060610)^{1, 2, 9} Ponten A.... Kochs G. (1997)
Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. (PubMed id 14752052)^{1, 2, 9} Turan K....Nagata K. (2004)
Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. (PubMed id 15047845)^{1, 2, 9} Andersson I....Mirazimi A. (2004)
Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. (PubMed id 15117331)^{1, 4, 9} Suzuki F....Kumada H. (2004)
Interferon-induced Mx proteins in antiviral host defense. (PubMed id 17570575)^{1, 3, 9} Haller O....Kochs G. (2007)
Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. (PubMed id 14872030)^{1, 4, 9} Torisu H....Hara T. (2004)
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (PubMed id 2161946)^{1, 2, 9} Pavlovic J.... Staeheli P. (1990)
Structural basis of oligomerization in the stalk regi on of dynamin-like MxA. (PubMed id 20428112)^{1, 2, 9} Gao S....Daumke O. (2010)
Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus. (PubMed id 16202617)^{1, 2, 9} Leroy M....Desmecht D. (2006)
Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PubMed id 15766558)^{1, 4, 9} Hamano E....Keicho N. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4599	HGNC: 7532	AceView: MX1	Ensembl:ENSG00000157601	euGenes: HUgn4599
ECgene: MX1	Kegg: 4599	H-InvDB: MX1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MX1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MX1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MX1 gene:
Search GeneIP for patents involving MX1

GeneCards and IP:
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