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Aliases for MX1 Gene

Aliases for MX1 Gene

  • MX Dynamin Like GTPase 1 2 3
  • Interferon-Regulated Resistance GTP-Binding Protein MxA 3 4
  • Interferon-Inducible Protein P78 2 3
  • Interferon-Induced Protein P78 3 4
  • Myxoma Resistance Protein 1 3 4
  • MX Dynamin-Like GTPase 1 3 5
  • IFI-78K 3 4
  • Myxovirus (Influenza) Resistance 1, Homolog Of Murine (Interferon-Inducible Protein P78) 2
  • Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 (Mouse) 2
  • Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 3
  • Myxovirus Resistance Protein 1 4
  • IFI78 3
  • MxA 3
  • MX 3

External Ids for MX1 Gene

Previous GeneCards Identifiers for MX1 Gene

  • GC21P039372
  • GC21P041713
  • GC21P041718
  • GC21P041720
  • GC21P042792
  • GC21P028262

Summaries for MX1 Gene

Entrez Gene Summary for MX1 Gene

  • This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for MX1 Gene

MX1 (MX Dynamin Like GTPase 1) is a Protein Coding gene. Diseases associated with MX1 include influenza and subacute sclerosing panencephalitis. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot for MX1 Gene

  • Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Gene Wiki entry for MX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MX1 Gene

Genomics for MX1 Gene

Regulatory Elements for MX1 Gene

Promoters for MX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MX1 Gene

Chromosome:
21
Start:
41,420,304 bp from pter
End:
41,459,214 bp from pter
Size:
38,911 bases
Orientation:
Plus strand

Genomic View for MX1 Gene

Genes around MX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MX1 Gene

Proteins for MX1 Gene

  • Protein details for MX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20591-MX1_HUMAN
    Recommended name:
    Interferon-induced GTP-binding protein Mx1
    Protein Accession:
    P20591
    Secondary Accessions:
    • B2RDA5
    • B3KU10
    • C9IYV7
    • C9J8D6
    • C9JN19
    • C9JN88
    • C9JUL1
    • C9JZS6
    • D3DSI8
    • Q86YP5
    • Q96CI3

    Protein attributes for MX1 Gene

    Size:
    662 amino acids
    Molecular mass:
    75520 Da
    Quaternary structure:
    • Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N.

    Three dimensional structures from OCA and Proteopedia for MX1 Gene

    Alternative splice isoforms for MX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MX1 Gene

Proteomics data for MX1 Gene at MOPED

Post-translational modifications for MX1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MX1 (MX1)

No data available for DME Specific Peptides for MX1 Gene

Domains & Families for MX1 Gene

Suggested Antigen Peptide Sequences for MX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20591

UniProtKB/Swiss-Prot:

MX1_HUMAN :
  • The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Domain:
  • The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
  • The middle domain mediates self-assembly and oligomerization.
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 GED domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with MX1: view

No data available for Gene Families for MX1 Gene

Function for MX1 Gene

Molecular function for MX1 Gene

GENATLAS Biochemistry:
myxovirus (influenza) resistance 1;human murine MX equivalent
UniProtKB/Swiss-Prot Function:
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
UniProtKB/Swiss-Prot Induction:
By type I and type III interferons. Isoform 2 is induced by HSV-1.
genes like me logo Genes that share phenotypes with MX1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MX1 Gene

Localization for MX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MX1 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). {ECO:0000269 PubMed:15047845, ECO:0000269 PubMed:21900240}.
Isoform 2: Cytoplasm. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). {ECO:0000269 PubMed:20603636}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MX1 Gene COMPARTMENTS Subcellular localization image for MX1 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 4
cytoskeleton 2
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21859714
genes like me logo Genes that share ontologies with MX1: view

Pathways & Interactions for MX1 Gene

genes like me logo Genes that share pathways with MX1: view

Gene Ontology (GO) - Biological Process for MX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 2154602
GO:0007165 signal transduction TAS 9389754
GO:0009615 response to virus IMP 15047845
GO:0045087 innate immune response TAS 16202617
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with MX1: view

No data available for SIGNOR curated interactions for MX1 Gene

Drugs & Compounds for MX1 Gene

(9) Drugs for MX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for MX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MX1: view

Transcripts for MX1 Gene

Unigene Clusters for MX1 Gene

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MX1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - -
SP2:
SP3: - -
SP4:
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 15b ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MX1 Gene

GeneLoc Exon Structure for
MX1
ECgene alternative splicing isoforms for
MX1

Expression for MX1 Gene

mRNA expression in normal human tissues for MX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MX1 Gene

This gene is overexpressed in Nasal epithelium (14.7), Lymph node (12.6), and Stomach (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MX1 Gene



SOURCE GeneReport for Unigene cluster for MX1 Gene Hs.517307

genes like me logo Genes that share expression patterns with MX1: view

Protein tissue co-expression partners for MX1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MX1 Gene

Orthologs for MX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MX1 36
  • 99 (a)
OneToOne
MX1 35
  • 98.89 (n)
  • 98.79 (a)
cow
(Bos Taurus)
Mammalia MX1 35
  • 80.2 (n)
  • 76.54 (a)
MX1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MX1 35
  • 80.11 (n)
  • 77.63 (a)
MX1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mx1 36
  • 69 (a)
OneToMany
Mx2 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mx2 35
  • 76.94 (n)
  • 75.27 (a)
chicken
(Gallus gallus)
Aves MX 36
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mx2 35
  • 64.2 (n)
  • 63.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11791 35
zebrafish
(Danio rerio)
Actinopterygii mxa 36
  • 52 (a)
ManyToMany
mxb 36
  • 52 (a)
ManyToMany
mxb 36
  • 50 (a)
ManyToMany
mxc 36
  • 50 (a)
ManyToMany
mxd 36
  • 43 (a)
ManyToMany
mxe 36
  • 53 (a)
ManyToMany
mxf 36
  • 41 (a)
ManyToMany
mxg 36
  • 44 (a)
ManyToMany
si:dkeyp-110c12.3 36
  • 42 (a)
ManyToMany
mxa 35
  • 58.39 (n)
  • 55.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta shi 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyn-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DRP4C 35
  • 44.52 (n)
  • 33.11 (a)
rice
(Oryza sativa)
Liliopsida Os04g0129900 35
  • 47.85 (n)
  • 37.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for MX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MX1 Gene

ENSEMBL:
Gene Tree for MX1 (if available)
TreeFam:
Gene Tree for MX1 (if available)

Paralogs for MX1 Gene

Paralogs for MX1 Gene

(3) SIMAP similar genes for MX1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MX1: view

Variants for MX1 Gene

Sequence variations from dbSNP and Humsavar for MX1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs34717738 - 41,446,010(+) TAATG(C/G/T)CTTTA reference, missense
rs2230454 - 41,458,602(+) CAGCA(G/T)CTTCA reference, missense
rs469390 - 41,446,003(+) AGAAA(A/G)TTAAT reference, missense
rs390467 -- 41,456,427(+) caggc(A/G)gaatt intron-variant
rs466112 -- 41,431,199(+) tgtat(A/C)tttag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MX1 Gene

Variant ID Type Subtype PubMed ID
nsv834102 CNV Loss 17160897
esv1009381 CNV Deletion 20482838
nsv459261 CNV Loss 19166990

Variation tolerance for MX1 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.09; 92.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MX1 Gene

HapMap Linkage Disequilibrium report
MX1
Human Gene Mutation Database (HGMD)
MX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MX1 Gene

Disorders for MX1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
subacute sclerosing panencephalitis
  • immunosuppressive measles encephalitis
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
alopecia areata
  • alopecia
lichen nitidus
  • pinkus' disease
- elite association - COSMIC cancer census association via MalaCards
Search MX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MX1

Genetic Association Database (GAD)
MX1
Human Genome Epidemiology (HuGE) Navigator
MX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MX1
genes like me logo Genes that share disorders with MX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MX1 Gene

Publications for MX1 Gene

  1. Structure and polymorphism of the human gene for the interferon- induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. (PMID: 10942113) Tazi-Ahnini R. … Cork M.J. (Hum. Genet. 2000) 3 4 23 67
  2. Interferon-induced Mx proteins in antiviral host defense. (PMID: 17570575) Haller O. … Kochs G. (Biochimie 2007) 2 3 23
  3. Inhibition of tumor cell motility by the interferon-inducible GTPase MxA. (PMID: 19297326) Mushinski J.F. … Trepel J.B. (J. Biol. Chem. 2009) 3 23
  4. The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population. (PMID: 19744071) Cao B. … Qi H. (Liver Int. 2009) 3 23
  5. [Genetic polymorphisms of MxA protein and eIF-2a-reg2 and their responses to interferon treatment in patients with chronic hepatitis B]. (PMID: 17407708) Huang Y.X. … Ma B. (Zhonghua Gan Zang Bing Za Zhi 2007) 3 23

Products for MX1 Gene

Sources for MX1 Gene

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