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MX1 Gene

protein-coding GIFtS: 65

GC21P041720

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
(Previous names: myxovirus (influenza) resistance 1, homolog of murine (interferon-inducible protein p78) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
IFI-78K ^¹, ², ³
IFI78 ^², ⁵
MX ^², ⁵
MxA ^¹, ²

Descriptions
Interferon-induced protein p78 ^³
Interferon-regulated resistance GTP-binding protein MxA ^³
Myxovirus resistance protein 1 ^², ³
human interferon-regulated resistance GTP-binding protein MXA ⁹
interferon inducible protein p78 ^²
interferon-induced GTP-binding protein Mx1 ^²
interferon-regulated resistance GTP-binding protein ^²
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) ^²
myxovirus (influenza) resistance 1, homolog of murine (interferon-inducible protein p78) ^¹

External Ids
HGNC: 7532¹
Entrez Gene: 4599²
UniProtKB: P20591³
Ensembl: ENSG00000157601⁷

Search outside databases for aliases for MX1 gene

Previous GC identifers: GC21P039372 GC21P041713 GC21P041718

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MX1:

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against

influenza virus infection. The protein encoded by this gene is similar to the mouse protein as

determined by its antigenic relatedness, induction conditions, physicochemical properties, and

amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the

family of large GTPases. Two transcript variants encoding the same protein have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591

Function: May regulate the calcium channel activity of TRPCs. Shows activity against influenza

virus and VSV, a rhabdovirus

Gene Wiki entry for MX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

MX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P041720:	GeneLoc	Nature:405,311-319
Start:	41,714,312 bp from pter	28,371,509 bp from centromere
End:	41,753,011 bp from pter	28,404,533 bp from centromere
Size:	38,700 bases	33,025 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	NM_002462
genomic clones:	KB447A5 to Q87D5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MX1_HUMAN, P20591 (See protein sequence)

Recommended Name: Interferon-induced GTP-binding protein Mx1

Size: 662 amino acids; 75534 Da

Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7

Subcellular location: Cytoplasm

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001138397.1 NP_002453.2

ENSEMBL proteins:

ENSP00000288383 ENSP00000381599 ENSP00000381601

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MX1)
	Human Recombinant Proteins from Abnova (MX1)

OriGene Purified Recombinant Human Protein: MX1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	16780588

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Antibodies for MX1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MX1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MX1)
	Novus Biologicals Antibody for MX1

Assays for MX1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P20591

ProtoNet protein and cluster: P20591

1 Blocks protein family: IPB001401 Dynamin

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591

Similarity: Belongs to the dynamin family

Similarity: Contains 1 GED domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MX1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002462

Applied Biosystems Silencer® siRNAs for MX1

Sigma-Aldrich siRNA and siRNA Panels for MX1

Sigma-Aldrich shRNA Panels and shRNA for MX1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MX1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144925
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144925
untagged cDNA clones in CMV expression vector (see all 2): NM_001144925

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002462

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591

Function: May regulate the calcium channel activity of TRPCs. Shows activity against influenza

virus and VSV, a rhabdovirus

Induction: By interferons

Genatlas biochemistry entry for MX1:

myxovirus (influenza) resistance 1;human murine MX equivalent

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	15757897
GO:0005525	GTP binding	TAS	2154602

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for MX1 (Your Favorite Gene powered by Ingenuity)

Interferon Signaling

GeneDecks MX1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MX1

5/49 Interacting proteins for MX1 (P20591¹ ENSP00000288383³) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRPC1	P48995¹, ENSP00000273482³	EBI-929476, EBI-929665 STRING (score=.944)
TRPC6	Q9Y210¹, ENSP00000340913³	EBI-929476, EBI-929362 STRING (score=.938)
TRPC3	Q13507¹	EBI-929476, EBI-520807
TRPC4	Q9UBN4¹	EBI-929476, EBI-929504
TRPC5	Q9UL62¹	EBI-929476, EBI-929550

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006917	induction of apoptosis	TAS	9389754
GO:0006952	defense response	TAS	2154602
GO:0007165	signal transduction	TAS	9389754
GO:0009615	response to virus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MX1
10/11 Novoseek chemical compound relationships for MX1 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ifn-alpha	69.82	19	9562412 (4), 12595530 (2), 17505473 (2), 11983232 (2) (see all 8)
gtp	46.92	38	8411374 (4), 11959118 (3), 7507812 (2), 7539430 (2) (see all 15)
poly(i-c)	42.20	4	14698216 (2), 10954913 (1), 16751646 (1)
neopterin	25.93	3	12522042 (1), 9858319 (1), 17420930 (1)
gdp	20.32	6	11959118 (2), 7507489 (2)
leucine	17.96	14	1281477 (4), 14698216 (2), 9781814 (1), 10954913 (1) (see all 7)
guanosine	17.04	2	15602733 (1), 16413306 (1)
rantes	11.75	3	18353943 (1), 16571117 (1), 14610214 (1)
glyceraldehyde 3-phosphate	10.17	2	17335844 (1), 12601105 (1)
atp	5.09	2	7507489 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MX1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002462

Sigma-Aldrich siRNA and siRNA Panels for MX1

Sigma-Aldrich shRNA Panels and shRNA for MX1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002462

REFSEQ mRNAs for MX1 gene (2 alternative transcripts):

NM_001144925.1 NM_002462.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002462

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144925
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144925
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001144925

Additional cDNA sequence:

AK093008.1 AK096355.1 AK225885.1 AK315465.1 AY186254.1 BC014222.2 BC032602.1 CR592170.1

CR595895.1 M30817.1 M33882.1

22 DOTS entries:

DT.97847397 DT.218632 DT.100793266 DT.100793277 DT.92450878 DT.218633 DT.95253378 DT.100793270

DT.95121282 DT.100009551 DT.100644751 DT.95276034 DT.100030600 DT.100793267 DT.121129973 DT.95276031

DT.101977467 DT.121129985 DT.75110933 DT.92450867 DT.95318508 DT.100754756

24/331 AceView cDNA sequences (see all 331 ):

CD370433 BU736637 N98766 BX482492 BQ447055 CD700744 BM669018 F05704

AL553896 BQ447080 AU121592 CB120263 CR592170 AI968983 AU133022 NM_002462

BQ688620 BQ068247 AI865200 BM704470 AA361869 BQ576219 BM673149 R88402

highest scoring ESTs for MX1:

M33882 AA004402 AA053202 AA112842 AA127870 AA128097 AA143789 AA193601 AA193638 AA232871

Unigene Cluster for MX1:

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

Hs.517307 [show with all ESTs]

Unigene Representative Sequence: AK096355

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MX1 (see all 13 )

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·
SP1:																																													-				-
SP2:
SP3:																																													-				-
SP4:
SP5:					-

ExUns:	15b	^	16	^	17	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MX1

3 Ensembl transcripts including schematic representations:

ENST00000288383 ENST00000398598 ENST00000398600

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MX1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MX1

¹ / ² / ³

3 probe-sets matching MX1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37014_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M33882	1.00	1.00	1.00	1
202086_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002462	0.60	1.00	0.82	1
202086_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MX1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTGCCGTGT

SOURCE GeneReport for Unigene cluster: Hs.517307
Expression variation in blood from EXPOLDB for MX1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MX1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MX1¹	--	myxovirus (influenza virus) resistance 1, interferon-inducible more	80.11(n) 77.63(a)	403745 NM_001003134.1 NP_001003134.1
chimpanzee (Pan troglodytes)	MX1¹	--	myxovirus (influenza virus) resistance 1, interferon-inducible more	98.84(n) 98.64(a)	474121 XM_001171874.1 XP_001171874.1
cow (Bos taurus)	MX1¹	--	myxovirus (influenza virus) resistance 1, interferon-inducible more	79.99(n) 76.39(a)	280872 NM_173940.2 NP_776365.1
rat (Rattus norvegicus)	Mx2¹	--	myxovirus (influenza virus) resistance 2	76.13(n) 73.75(a)	286918 NM_134350.2 NP_599177.2
mouse (Mus musculus)	Mx2⁵	16 (71.20 cM)	myxovirus (influenza virus) resistance 2	--	J03368

About this table Species with no ortholog for MX1

ENSEMBL Gene Tree for MX1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MX1 gene

MX2² OPA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/341 NCBI SNPs in MX1 are shown (see all 341 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 156)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs469390^1,2	A,C,F,H,O	41739800(+)	`AGAAAA/GTTAAT`	1	I/V	mis¹		27		MN NA EU EA WA NS CSAM	1774
	rs1557370^1,2	A,C,F,H	41752560(+)	`ACCACA/GCTCTG`	1	--	ut3¹ ese³		13		MN EU EA WA NA	1208
	rs464783^1,2	A,C,F,H	41718350(+)	`TTTAGC/TGGGGG`	1	--	ng5¹		8		EA NA EU WA	568
	rs462903^1,2	A,C,F	41719476(+)	`GAGAGA/GCCAGA`	1	--	ng5¹		1		MN	184
	rs2230454^1,2	C,F,H	41752399(+)	`CAGCAG/TCTTCA`	1	Q/H	mis¹ ese³		9		MN EU EA WA	890
--	rs462687^1,2	A,F,O	41718927(+)	`TAACTG/ATTTtc`	1	--	ng5¹		1		NA	9
	rs2230456^1,2	F,H	41752663(+)	`AGTCCG/ATCTCT`	1	--	ut3¹ ese³		5		MN EU EA WA	442
--	rs2071430^1,2	C,F	41719935(+)	`TCTGCG/TCCCGG`	1	--	ng5¹		7		MN EA CSAM	764
	rs464138^1,2	C,F	41720043(+)	`ACTCCA/CGCACT`	1	--	ut5¹ tfbs³		8		MN EA CSAM	936
--	rs429155^1,2	A,C	41718826(+)	`GCTTTC/TGAGAT`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for MX1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 147150

10/56 Novoseek disease relationships for MX1 gene (see all 56 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
vesicular stomatitis	79.68	19	2161946 (2), 15812245 (1), 7507812 (1), 9060610 (1) (see all 17)
influenza	72.05	106	18199636 (5), 16704297 (5), 1548781 (5), 1321288 (5) (see all 51)
rna virus infections	68.84	2	7831843 (1)
virus infection	68.76	72	12858204 (4), 16704297 (4), 11551256 (4), 9562412 (4) (see all 43)
multiple sclerosis	68.66	19	14607790 (3), 16843495 (2), 11536237 (2), 14529316 (1) (see all 15)
rift valley fever	59.38	1	17970694 (1)
multiple sclerosis relapsing-remitting	56.12	1	11516761 (1)
hepatitis c chronic	55.05	5	12210408 (1), 15117331 (1), 15684819 (1), 16894313 (1)
lupus erythematosus	54.21	2	10070906 (1), 7822763 (1)
hepatitis c	47.89	13	10213463 (2), 11805446 (2), 10971132 (2), 15117331 (1) (see all 10)

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1 PharmGKB disease relationship for MX1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Gene Mutation Database: MX1
Genetic Association Database: MX1
Human Genome Epidemiology Navigator: MX1 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/317 PubMed articles for MX1 gene (see all 317 ):

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. (PubMed id 9060610)^{1, 3, 4} Ponten A....Kochs G. (1997)
Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. (PubMed id 15117331)^{1, 3, 6} Suzuki F....Kumada H. (2004)
Interferon-induced Mx proteins in antiviral host defense. (PubMed id 17570575)^{1, 2, 3} Haller O....Kochs G. (2007)
Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. (PubMed id 14872030)^{1, 3, 6} Torisu H....Hara T. (2004)
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PubMed id 12944978)^{1, 3, 6} Knapp S....Thursz M.R. (2003)
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (PubMed id 2161946)^{1, 3, 4} Pavlovic J.... Staeheli P. (1990)
Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PubMed id 15766558)^{1, 3, 6} Hamano E....Keicho N. (2005)
Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)^{1, 3, 6} King J.K....Chen P.J. (2002)
Cloning and sequence analyses of cDNAs for interferon- and virus- induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter. (PubMed id 2154602)^{1, 3, 4} Horisberger M.A....Content J. (1990)
[A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes] (PubMed id 16390004)^{3, 6} Wang H.W....Cao W.C. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4599	HGNC: 7532	AceView: MX1	Ensembl:ENSG00000157601	euGenes: HUgn4599
ECgene: MX1	H-InvDB: MX1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for MX1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MX1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MX1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MX1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MX1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Antibodies for MX1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MX1 Gene at Home site.
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MX1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MX1

Summaries
for MX1

Genomic Location
for MX1

Proteins
for MX1

Protein Domains/
Families
for MX1

Gene Function
for MX1

Pathways & Interactions
for MX1

Drugs & Compounds
for MX1

Transcripts
for MX1

Expression
for MX1

Orthologs
for MX1

Paralogs
for MX1

SNPs/Variants
for MX1

Disorders & Mutations
for MX1

Medical News
for MX1

Publications
for MX1

Search for MX1

Genome Databases showing MX1

Other Databases showing MX1

Specialized Databases showing MX1

Licensable Technologies
for MX1

Services
for MX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MX1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MX1

Summariesfor MX1

Genomic Locationfor MX1

Proteinsfor MX1

Protein Domains/Familiesfor MX1

Gene Functionfor MX1

Pathways & Interactionsfor MX1

Drugs & Compoundsfor MX1

Transcriptsfor MX1

Expression for MX1

Orthologsfor MX1

Paralogsfor MX1

SNPs/Variantsfor MX1

Disorders & Mutationsfor MX1

Medical Newsfor MX1

Publicationsfor MX1

Search for MX1

Genome Databases showing MX1

Other Databases showing MX1

Specialized Databases showing MX1

Licensable Technologiesfor MX1

Servicesfor MX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MX1

Summaries
for MX1

Genomic Location
for MX1

Proteins
for MX1

Protein Domains/
Families
for MX1

Gene Function
for MX1

Pathways & Interactions
for MX1

Drugs & Compounds
for MX1

Transcripts
for MX1

Expression
for MX1

Orthologs
for MX1

Paralogs
for MX1

SNPs/Variants
for MX1

Disorders & Mutations
for MX1

Medical News
for MX1

Publications
for MX1

Licensable Technologies
for MX1

Services
for MX1