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MX1 Gene

protein-coding   GIFtS: 65
GCID: GC21P042792

Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible...

(Previous names: myxovirus (influenza) resistance 1, homolog of murine (interferon-inducible...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein
P78 (Mouse)1 2
     MX2 5
Interferon-Induced Protein P782 3     Myxovirus (Influenza) Resistance 1, Homolog Of Murine
(Interferon-Inducible Protein P78)1
Interferon-Regulated Resistance GTP-Binding Protein MxA2 3     Human Interferon-Regulated Resistance GTP-Binding Protein MXA11
Myxoma Resistance Protein 12 3     MxA2
IFI-78K2 3     Interferon-Induced GTP-Binding Protein Mx12
IFI782 5     Myxovirus Resistance Protein 13

External Ids:    HGNC: 75321   Entrez Gene: 45992   Ensembl: ENSG000001576017   OMIM: 1471505   UniProtKB: P205913   

Export aliases for MX1 gene to outside databases

Previous GC identifers: GC21P039372 GC21P041713 GC21P041718 GC21P041720 GC21P028262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MX1 Gene:
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral
response. The encoded protein is induced by type I and type II interferons and antagonizes the replication
process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on
chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for MX1 Gene:
MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)) is a protein-coding gene. Diseases associated with MX1 include subacute sclerosing panencephalitis, and rift valley fever. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot: MX1_HUMAN, P20591
Function: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and
some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and
inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits
thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse
virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome
amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP
synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death
after influenza virus infection. May regulate the calcium channel activity of TRPCs

Gene Wiki entry for MX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MX1 gene promoter:
         CREB   AP-1   deltaCREB   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MX1 promoter sequence

   Search Chromatin IP Primers for MX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
MX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MX1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P042792:   GeneLoc Nature:405,311-319
Start:
42,792,231 bp from pter       28,371,509 bp from centromere
End:
42,831,141 bp from pter 28,404,533 bp from centromere
Size:
38,911 bases 33,025 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: NM_002462
genomic clones: KB447A5 to Q87D5


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MX1_HUMAN, P20591 (See protein sequence)
Recommended Name: Interferon-induced GTP-binding protein Mx1  
Size: 662 amino acids; 75520 Da
Subunit: Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk
domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target
structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with
DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with
THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N
3 PDB 3D structures from and Proteopedia for MX1:
3LJB (3D)        3SZR (3D)        3ZYS (3D)    
Secondary accessions: B2RDA5 B3KU10 C9IYV7 C9J8D6 C9JN19 C9JN88 C9JUL1 C9JZS6 D3DSI8 Q86YP5
Q96CI3
Alternative splicing: 2 isoforms:  P20591-1   P20591-2   

Explore the universe of human proteins at neXtProt for MX1: NX_P20591

Explore proteomics data for MX1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138397.1  NP_001171517.1  NP_001269849.1  NP_002453.2  

    ENSEMBL proteins: 
     ENSP00000381601   ENSP00000408498   ENSP00000392151   ENSP00000381599   ENSP00000400923  
     ENSP00000402215   ENSP00000393931   ENSP00000410989   ENSP00000288383   ENSP00000410523  
    Reactome Protein details: P20591

    MX1 Human Recombinant Protein Products:

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    Novus Biologicals MX1 Protein
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    Cloud-Clone Corp. Proteins for MX1

    MX1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for MX1

    MX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MX1
    Cloud-Clone Corp. CLIAs for MX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR003130 GED
     IPR020850 GTPase_effector_domain_GED
     IPR022812 Dynamin_SF
     IPR019762 Dynamin_GTPase_CS
     IPR000375 Dynamin_central

    Graphical View of Domain Structure for InterPro Entry P20591

    ProtoNet protein and cluster: P20591

    1 Blocks protein domain: IPB001401 Dynamin

    UniProtKB/Swiss-Prot: MX1_HUMAN, P20591
    Domain: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition
    Domain: The middle domain mediates self-assembly and oligomerization
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain


    MX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MX1_HUMAN, P20591
    Function: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and
    some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and
    inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits
    thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse
    virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome
    amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP
    synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death
    after influenza virus infection. May regulate the calcium channel activity of TRPCs
    Induction: By type I and type III interferons. Isoform 2 is induced by HSV-1

         Genatlas biochemistry entry for MX1:
    myxovirus (influenza) resistance 1;human murine MX equivalent

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI15047845
    GO:0005525GTP binding IEA--
         
    MX1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MX1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MX1

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MX1
    Predesigned siRNA for gene silencing in human, mouse, rat MX1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MX1 (see all 16)
    OriGene ORF clones in mouse, rat for MX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MX1 (NM_004097)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MX1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MX1_HUMAN, P20591: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
    Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with
    CCHFV protein N in the perinuclear region
    MX1_HUMAN, P20591: Isoform 2: Cytoplasm. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    nucleus5
    cytoskeleton1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IDA15047845

    MX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    2Influenza A
    Influenza A0.34
    Measles0.34
    3Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MX1
        Interferon alpha/beta signaling
    ISG15 antiviral mechanism


    2 Kegg Pathways  (Kegg details for MX1):
        Measles
    Influenza A


    MX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MX1: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MX1 (P205911, 3 ENSP000003815994) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPC3Q135071, 3, ENSP000003689664EBI-929476,EBI-520807 I2D: score=3 STRING: ENSP00000368966
    TRPC6Q9Y2101, 3, ENSP000003409134EBI-929476,EBI-929362 I2D: score=3 STRING: ENSP00000340913
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS9389754
    GO:0006952defense response TAS2154602
    GO:0007165signal transduction TAS9389754
    GO:0009615response to virus IMP15047845
    GO:0019221cytokine-mediated signaling pathway TAS--

    MX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MX1

    Selected Novoseek inferred chemical compound relationships for MX1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 89.2 29 9036986 (2), 7861026 (1), 10702714 (1), 15745156 (1) (see all 27)
    betaseron 79.2 5 10851362 (2), 19857496 (1), 11516761 (1), 15589054 (1)
    avonex 77.2 5 10851362 (2), 16601938 (1), 11516761 (1), 15589054 (1)
    rebif 74.5 4 10851362 (2), 16601938 (1), 11516761 (1)
    ifn-alpha 71.5 22 9562412 (4), 12595530 (2), 17505473 (2), 17763410 (2) (see all 10)
    ribavirin 49.9 3 12210408 (2), 12719586 (1)
    gtp 47.1 38 8411374 (4), 11959118 (3), 7507812 (2), 7539430 (2) (see all 15)
    poly(i-c) 40.9 4 14698216 (2), 10954913 (1), 16751646 (1)
    imiquimod 39.7 6 15769273 (3), 15611427 (1), 16077073 (1), 9367544 (1)
    neopterin 24.3 3 12522042 (1), 9858319 (1), 17420930 (1)



    MX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MX1 gene (4 alternative transcripts): 
    NM_001144925.2  NM_001178046.2  NM_001282920.1  NM_002462.4  

    Unigene Cluster for MX1:

    Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
    Hs.517307  [show with all ESTs]
    Unigene Representative Sequence: AK096355
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490220 ENST00000468506 ENST00000398600(uc002yzh.3) ENST00000413778
    ENST00000419044 ENST00000398598(uc002yzi.3 uc010goq.3) ENST00000424365
    ENST00000484465 ENST00000417963 ENST00000441677 ENST00000478268 ENST00000427464
    ENST00000288383 ENST00000467510 ENST00000486275 ENST00000491110 ENST00000455164

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector: MX1 (NM_004097)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat MX1

    Additional mRNA sequence: 

    AK093008.1 AK096355.1 AK225885.1 AK315465.1 AY186254.1 BC014222.2 BC032602.1 M30817.1 
    M33882.1 

    22 DOTS entries:

    DT.97847397  DT.218632  DT.100793266  DT.100793277  DT.92450878  DT.100793270  DT.218633  DT.95121282 
    DT.100009551  DT.100644751  DT.95276034  DT.100030600  DT.100793267  DT.121129973  DT.95276031  DT.101977467 
    DT.121129985  DT.92450867  DT.95318508  DT.100754756  DT.75110933  DT.95253378 

    Selected AceView cDNA sequences (see all 331):

    BM464205 AA426260 CD700744 BM669018 BQ576219 CD367498 CR595895 AU121592 
    CD370433 BU150025 BQ688620 AL553896 N98766 CR592170 BQ068247 BQ774424 
    AI865200 NM_002462 BM992966 CB120263 BQ017516 BM673149 CA306706 BM704470 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MX1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
    SP1:                                                                                                                                      -           -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                      -           -         
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 15b ^ 16 ^ 17 ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for MX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MX1 expression in normal human tissues (normalized intensities)      MX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGCCGTGT
    MX1 Expression
    About this image


    MX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Gall Bladder (Hepatobiliary System)
     
     Spleen (Hematopoietic System)
    MX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517307
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MX1: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MX1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mx25 myxovirus (influenza virus) resistance 2   --   16 (57.51 cM) 97536083 
    chicken
    (Gallus gallus)
    Aves MX6
    Gallus gallus myxovirus (influenza virus) resistan...
    44(a)
    1 → many
    1(108280289-108296301)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    52(a)
    many ↔ many
    many ↔ many
    3(138462835-138488436)
    3(138430803-138440967)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mx21 myxovirus (influenza virus) resistance 2 (mouse) 64.2(n)
    63.97(a)
      101732122  XM_004912412.1  XP_004912469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mxa2 myxovirus (influenza) resistance A 73.72(n)   360142  AF533769.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shi6
    shibire
    18(a)
    1 → many
    X(15786149-15800725)
    worm
    (Caenorhabditis elegans)
    Secernentea dyn-16
    Protein DYN-1, isoform a (dyn-1) mRNA, complete cd...
    21(a)
    1 → many
    X(15568916-15573693) WBGene00001130
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS16
    Dynamin-like GTPase required for vacuolar sorting;...
    26(a)
    1 → many
    XI(440608-442722) YKR001C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DRP4C1 DRP4C 44.52(n)
    33.11(a)
      842345  NM_104736.2  NP_176252.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g01299001 Os04g0129900 47.85(n)
    37.47(a)
      4335000  NM_001058628.2  NP_001052093.2 


    ENSEMBL Gene Tree for MX1 (if available)
    TreeFam Gene Tree for MX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MX1 gene
    DNM12  MX22  DNM22  DNM1L2  DNM32  
    3 SIMAP similar genes for MX1 using alignment to 8 protein entries:     MX1_HUMAN (see all proteins):
    MX2    DNM1L    DNM3

    MX1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MX1
    PGOHUM00000245457 PGOHUM00000245459 PGOHUM00000245461 PGOHUM00000245462 PGOHUM00000245463


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MX1 (see all 1159)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172510801,2
    F--33338567(+) CTCACC/TGGAGC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1909576211,2
    --33338579(+) CCCCTC/TGATCA 1 -- us2k10--------
    rs1145434721,2
    C,F--33338603(+) TAGCAC/TGCGCC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1149182771,2
    F--33338620(+) TGTGGG/AGTACA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1821182661,2
    --33338699(+) CAAGGA/TAAGTT 1 -- us2k10--------
    rs7583431,2
    C,A--33338723(+) TTTTAT/CTTTTT 1 -- us2k15Minor allele frequency- C:0.18WA CSA NA EA 362
    rs1434775941,2
    --33338845(+) AGTAGC/GTGGAA 1 -- us2k10--------
    rs1462572471,2
    --33338925(+) ATGAGA/CTTTTG 1 -- us2k10--------
    rs1878819171,2
    --33338941(+) GCCTAC/TTCGCT 1 -- us2k10--------
    rs796554681,2
    C,F--33338944(+) TATTCG/TCTTCC 1 -- us2k13Minor allele frequency- T:0.10WA NA EA 358

    HapMap Linkage Disequilibrium report for MX1 (42792231 - 42831141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009381CNV Deletion20482838
    nsv834102CNV Loss17160897
    nsv459261CNV Loss19166990

    Human Gene Mutation Database (HGMD): MX1
    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147150    OMIM disorders: --

    Selected diseases for MX1 (see all 75):    About MalaCards
    subacute sclerosing panencephalitis    rift valley fever    influenza    viral encephalitis
    crimean-congo hemorrhagic fever    rabies    bell's palsy    temporal arteritis
    stomatitis    measles    primary progressive multiple sclerosis    parainfluenza virus type 3
    biliary atresia    newcastle disease    hemorrhagic fever    west nile virus
    severe acute respiratory syndrome    polymyalgia rheumatica    cryoglobulinemia    cutaneous lupus erythematosus

    4 diseases from the University of Copenhagen DISEASES database for MX1:
    Influenza     Multiple sclerosis     Breast cancer     Hepatitis C

    MX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MX1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vesicular stomatitis 80.7 19 2161946 (2), 15812245 (1), 7507812 (1), 9060610 (1) (see all 17)
    influenza 70.4 108 18199636 (5), 16704297 (5), 1548781 (5), 1321288 (5) (see all 53)
    multiple sclerosis 70.2 22 14607790 (3), 16843495 (2), 11536237 (2), 14529316 (1) (see all 18)
    virus infection 69.1 74 12858204 (4), 16704297 (4), 11551256 (4), 9562412 (4) (see all 45)
    rna virus infections 65.1 2 7831843 (1)
    multiple sclerosis relapsing-remitting 62.2 1 11516761 (1)
    rift valley fever 57.2 1 17970694 (1)
    lupus erythematosus 55.4 2 10070906 (1), 7822763 (1)
    hepatitis c chronic 53.2 5 12210408 (1), 15117331 (1), 15684819 (1), 16894313 (1)
    hepatitis c 47.8 14 10213463 (2), 11805446 (2), 10971132 (2), 19635103 (1) (see all 11)

    Genetic Association Database (GAD): MX1
    Human Genome Epidemiology (HuGE) Navigator: MX1 (26 documents)

    Export disorders for MX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MX1 gene, integrated from 10 sources (see all 401):
    (articles sorted by number of sources associating them with MX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and polymorphism of the human gene for the interferon- induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. (PubMed id 10942113)1, 2, 9 Tazi-Ahnini R.... Cork M.J. (Hum. Genet. 2000)
    2. Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. (PubMed id 9060610)1, 2, 9 Ponten A.... Kochs G. (J. Virol. 1997)
    3. Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. (PubMed id 14752052)1, 2, 9 Turan K.... Nagata K. (Nucleic Acids Res. 2004)
    4. Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. (PubMed id 15047845)1, 2, 9 Andersson I.... Mirazimi A. (J. Virol. 2004)
    5. Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. (PubMed id 15117331)1, 4, 9 Suzuki F....Kumada H. (J. Viral Hepat. 2004)
    6. Interferon-induced Mx proteins in antiviral host defense. (PubMed id 17570575)1, 3, 9 Haller O....Kochs G. (Biochimie 2007)
    7. [Genetic polymorphisms of MxA protein and eIF-2a-reg2 and their responses to interferon treatment in patients with chronic hepatitis B]. (PubMed id 17407708)1, 4, 9 Huang Y.X....Ma B. (Zhonghua Gan Zang Bing Za Zhi 2007)
    8. Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study. (PubMed id 16824203)1, 4, 9 He J....Cao W. (BMC Infect. Dis. 2006)
    9. Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. (PubMed id 14872030)1, 4, 9 Torisu H....Hara T. (Neurology 2004)
    10. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. (PubMed id 8411374)1, 2, 9 Pitossi F.... Staeheli P. (J. Virol. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4599 HGNC: 7532 AceView: MX1 Ensembl:ENSG00000157601 euGenes: HUgn4599
    ECgene: MX1 Kegg: 4599 H-InvDB: MX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MX1 gene:
    Search GeneIP for patents involving MX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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