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Aliases for MVP Gene

Aliases for MVP Gene

  • Major Vault Protein 2 3
  • Lung Resistance-Related Protein 2 3 4
  • LRP 3 4
  • VAULT1 3

External Ids for MVP Gene

Previous GeneCards Identifiers for MVP Gene

  • GC16M029301
  • GC16P030151
  • GC16P029826
  • GC16P029869
  • GC16P029739
  • GC16P029831
  • GC16P027492
  • GC16P029832
  • GC16P029840

Summaries for MVP Gene

Entrez Gene Summary for MVP Gene

  • This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MVP Gene

MVP (Major Vault Protein) is a Protein Coding gene. Diseases associated with MVP include mesial temporal lobe epilepsy with hippocampal sclerosis and core binding factor acute myeloid leukemia. GO annotations related to this gene include protein kinase binding and protein phosphatase binding.

UniProtKB/Swiss-Prot for MVP Gene

  • Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Gene Wiki entry for MVP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MVP Gene

Genomics for MVP Gene

Regulatory Elements for MVP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MVP Gene

Chromosome:
16
Start:
29,820,394 bp from pter
End:
29,848,039 bp from pter
Size:
27,646 bases
Orientation:
Plus strand

Genomic View for MVP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MVP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MVP Gene

Proteins for MVP Gene

  • Protein details for MVP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14764-MVP_HUMAN
    Recommended name:
    Major vault protein
    Protein Accession:
    Q14764
    Secondary Accessions:
    • Q96BG4
    • Q9BPW6
    • Q9BQT1
    • Q9UBD1

    Protein attributes for MVP Gene

    Size:
    893 amino acids
    Molecular mass:
    99327 Da
    Quaternary structure:
    • The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.

    Three dimensional structures from OCA and Proteopedia for MVP Gene

neXtProt entry for MVP Gene

Proteomics data for MVP Gene at MOPED

Post-translational modifications for MVP Gene

Antibody Products

No data available for DME Specific Peptides for MVP Gene

Domains & Families for MVP Gene

Protein Domains for MVP Gene

Suggested Antigen Peptide Sequences for MVP Gene

Graphical View of Domain Structure for InterPro Entry

Q14764

UniProtKB/Swiss-Prot:

MVP_HUMAN :
  • MVP 3 mediates interaction with PTEN
  • Contains 9 MVP (vault) repeats.
Domain:
  • MVP 3 mediates interaction with PTEN
  • MVP 4 mediates interaction with PARP4
Similarity:
  • Contains 9 MVP (vault) repeats.
genes like me logo Genes that share domains with MVP: view

No data available for Gene Families for MVP Gene

Function for MVP Gene

Molecular function for MVP Gene

GENATLAS Biochemistry:
major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory functions,overexpressed in acute myeloid leukemia resistant to chemotherapy
UniProtKB/Swiss-Prot Function:
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15133037
GO:0019901 protein kinase binding IPI 16441665
GO:0019903 protein phosphatase binding IDA 15133037
genes like me logo Genes that share ontologies with MVP: view
genes like me logo Genes that share phenotypes with MVP: view

Animal Models for MVP Gene

MGI Knock Outs for MVP:

Animal Model Products

miRNA for MVP Gene

miRTarBase miRNAs that target MVP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MVP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MVP Gene

Localization for MVP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MVP Gene

Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MVP Gene COMPARTMENTS Subcellular localization image for MVP gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15133037
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IDA 16441665
GO:0005856 cytoskeleton IDA 16441665
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MVP: view

Pathways & Interactions for MVP Gene

SuperPathways for MVP Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0023057 negative regulation of signaling IDA 16441665
GO:0031953 negative regulation of protein autophosphorylation IDA 16441665
GO:0038127 ERBB signaling pathway IDA 15133037
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with MVP: view

No data available for Pathways by source and SIGNOR curated interactions for MVP Gene

Drugs & Compounds for MVP Gene

(31) Drugs for MVP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma 81
Bleomycin Approved Pharma 142
Bromocriptine Approved, Investigational Pharma Partial agonist, Agonist 27
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525

(13) Additional Compounds for MVP Gene - From: NovoSeek

genes like me logo Genes that share compounds with MVP: view

Transcripts for MVP Gene

Unigene Clusters for MVP Gene

Major vault protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MVP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MVP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12:
SP13: - -
SP14: - -
SP15: - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MVP Gene

GeneLoc Exon Structure for
MVP
ECgene alternative splicing isoforms for
MVP

Expression for MVP Gene

mRNA expression in normal human tissues for MVP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MVP Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for MVP Gene

This gene is overexpressed in Bone marrow stromal cell (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MVP Gene



SOURCE GeneReport for Unigene cluster for MVP Gene Hs.632177

mRNA Expression by UniProt/SwissProt for MVP Gene

Q14764-MVP_HUMAN
Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
genes like me logo Genes that share expression patterns with MVP: view

Protein tissue co-expression partners for MVP Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MVP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MVP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MVP 35
  • 87.15 (n)
  • 90.11 (a)
MVP 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MVP 35
  • 87.98 (n)
  • 91.35 (a)
LRP 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mvp 35
  • 86.62 (n)
  • 91.83 (a)
Mvp 16
Mvp 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mvp 35
  • 86.35 (n)
  • 91.48 (a)
oppossum
(Monodelphis domestica)
Mammalia MVP 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MVP 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MVP 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MVP 35
  • 70.31 (n)
  • 69.95 (a)
MVP 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MVP 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mvp 35
  • 71.07 (n)
  • 73.45 (a)
Str.15344 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68839 35
zebrafish
(Danio rerio)
Actinopterygii mvp 35
  • 68.55 (n)
  • 71.96 (a)
mvp 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11019 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6610 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for MVP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MVP Gene

ENSEMBL:
Gene Tree for MVP (if available)
TreeFam:
Gene Tree for MVP (if available)

Paralogs for MVP Gene

No data available for Paralogs for MVP Gene

Variants for MVP Gene

Sequence variations from dbSNP and Humsavar for MVP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1050809 -- 29,846,185(+) ACTGC(A/C)AAGGC synonymous-codon, reference
rs1050839 -- 29,847,830(+) AACCT(C/T)TTCAA reference, synonymous-codon
rs1050849 -- 29,847,886(+) GGGCA(A/G)AAGGG missense, reference
rs1063541 -- 29,840,390(+) GTGGT(C/G)CAGGA frameshift-variant, reference
rs1131328 -- 29,845,963(+) TTTTG(A/G)AGCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MVP Gene

Variant ID Type Subtype PubMed ID
nsv833186 CNV Loss 17160897
nsv827611 CNV Gain 20364138
nsv518568 CNV Gain 19592680
esv33498 CNV Gain 17666407

Variation tolerance for MVP Gene

Residual Variation Intolerance Score: 8.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MVP Gene

HapMap Linkage Disequilibrium report
MVP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVP Gene

Disorders for MVP Gene

MalaCards: The human disease database

(7) MalaCards diseases for MVP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
mesial temporal lobe epilepsy with hippocampal sclerosis
core binding factor acute myeloid leukemia
  • cbf acute myeloid leukemia
uterine sarcoma
  • uterine corpus sarcoma
testicular cancer
  • testicular tumor
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
- elite association
Search MVP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MVP

Human Genome Epidemiology (HuGE) Navigator
MVP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MVP
genes like me logo Genes that share disorders with MVP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MVP Gene

Publications for MVP Gene

  1. Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy. (PMID: 19875192) Li J. … Li X.Q. (Lung Cancer 2010) 23 67
  2. Expression of MRP1, BCRP, LRP and ERCC1 as prognostic factors in non-small cell lung cancer patients receiving postoperative cisplatin-based chemotherapy. (PMID: 20082278) Li X.Q. … Bao Q.L. (Int. J. Biol. Markers 2009) 23 67
  3. Expression of MRP1, BCRP, LRP, and ERCC1 in advanced non-small-cell lung cancer: correlation with response to chemotherapy and survival. (PMID: 19900859) Li J. … Chen P. (Clin Lung Cancer 2009) 23 67
  4. Major vault protein is expressed along the nucleus-neurite axis and associates with mRNAs in cortical neurons. (PMID: 19029061) Paspalas C.D. … Lombroso P.J. (Cereb. Cortex 2009) 23 67
  5. Establishment and biological analysis of the EC109/CDDP multidrug-resistant esophageal squamous cell carcinoma cell line. (PMID: 19513506) Wen J. … Fu J.H. (Oncol. Rep. 2009) 23 67

Products for MVP Gene

Sources for MVP Gene

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