Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MVP Gene

Aliases for MVP Gene

  • Major Vault Protein 2 3
  • Lung Resistance-Related Protein 2 3 4
  • LRP 3 4 6
  • VAULT1 3

External Ids for MVP Gene

Summaries for MVP Gene

Entrez Gene Summary for MVP Gene

  • This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MVP Gene

MVP (Major Vault Protein) is a Protein Coding gene. Diseases associated with MVP include mesial temporal lobe epilepsy with hippocampal sclerosis and lung cancer. GO annotations related to this gene include protein kinase binding and protein phosphatase binding.

UniProtKB/Swiss-Prot for MVP Gene

  • Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Gene Wiki entry for MVP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MVP Gene

Genomics for MVP Gene

Genomic Location for MVP Gene

Start:
29,820,394 bp from pter
End:
29,848,039 bp from pter
Size:
27,646 bases
Orientation:
Plus strand

Genomic View for MVP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MVP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MVP Gene

Regulatory Elements for MVP Gene

Proteins for MVP Gene

  • Protein details for MVP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14764-MVP_HUMAN
    Recommended name:
    Major vault protein
    Protein Accession:
    Q14764
    Secondary Accessions:
    • Q96BG4
    • Q9BPW6
    • Q9BQT1
    • Q9UBD1

    Protein attributes for MVP Gene

    Size:
    893 amino acids
    Molecular mass:
    99327 Da
    Quaternary structure:
    • The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.

    Three dimensional structures from OCA and Proteopedia for MVP Gene

neXtProt entry for MVP Gene

Proteomics data for MVP Gene at MOPED

Post-translational modifications for MVP Gene

No data available for DME Specific Peptides for MVP Gene

Domains for MVP Gene

Protein Domains for MVP Gene

UniProtKB/Swiss-Prot:

MVP_HUMAN
Domain:
  • MVP 3 mediates interaction with PTEN:
    • Q14764
  • MVP 4 mediates interaction with PARP4:
    • Q14764
Similarity:
  • Contains 9 MVP (vault) repeats.:
    • Q14764
genes like me logo Genes that share domains with MVP: view

No data available for Gene Families for MVP Gene

Function for MVP Gene

Molecular function for MVP Gene

GENATLAS Biochemistry: major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory functions,overexpressed in acute myeloid leukemia resistant to chemotherapy
UniProtKB/Swiss-Prot Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
UniProtKB/Swiss-Prot Induction: Up-regulated by IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15133037
GO:0019901 protein kinase binding IPI 16441665
GO:0019903 protein phosphatase binding IDA 15133037
genes like me logo Genes that share ontologies with MVP: view
genes like me logo Genes that share phenotypes with MVP: view

Animal Models for MVP Gene

MGI Knock Outs for MVP:

miRNA for MVP Gene

miRTarBase miRNAs that target MVP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MVP Gene

Localization for MVP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MVP Gene

Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MVP Gene COMPARTMENTS Subcellular localization image for MVP gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15133037
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IDA 16441665
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MVP: view

Pathways for MVP Gene

SuperPathways for MVP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
GO:0015031 protein transport IEA --
GO:0023057 negative regulation of signaling IDA 16441665
GO:0031953 negative regulation of protein autophosphorylation IDA 16441665
GO:0038127 ERBB signaling pathway IDA 15133037
genes like me logo Genes that share ontologies with MVP: view

No data available for Pathways by source for MVP Gene

Compounds for MVP Gene

(44) Novoseek inferred chemical compound relationships for MVP Gene

Compound -log(P) Hits PubMed IDs
daunorubicin 73.3 21
rhodamine 123 71.7 4
doxorubicin 70.3 29
vincristine 63.4 14
etoposide 61.4 10
genes like me logo Genes that share compounds with MVP: view

Transcripts for MVP Gene

Unigene Clusters for MVP Gene

Major vault protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MVP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12:
SP13: - -
SP14: - -
SP15: - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MVP Gene

GeneLoc Exon Structure for
MVP
ECgene alternative splicing isoforms for
MVP

Expression for MVP Gene

mRNA expression in normal human tissues for MVP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MVP Gene

This gene is overexpressed in Whole Blood (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MVP Gene

SOURCE GeneReport for Unigene cluster for MVP Gene Hs.632177

mRNA Expression by UniProt/SwissProt for MVP Gene

Q14764-MVP_HUMAN
Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
genes like me logo Genes that share expressions with MVP: view

Orthologs for MVP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MVP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MVP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MVP 36
  • 87.15 (n)
  • 90.11 (a)
MVP 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP 37
  • 91 (a)
OneToOne
MVP 36
  • 87.98 (n)
  • 91.35 (a)
mouse
(Mus musculus)
Mammalia Mvp 36
  • 86.62 (n)
  • 91.83 (a)
Mvp 16
Mvp 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MVP 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MVP 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mvp 36
  • 86.35 (n)
  • 91.48 (a)
chicken
(Gallus gallus)
Aves MVP 36
  • 70.31 (n)
  • 69.95 (a)
MVP 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MVP 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68839 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mvp 36
  • 71.07 (n)
  • 73.45 (a)
Str.15344 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11019 36
zebrafish
(Danio rerio)
Actinopterygii mvp 36
  • 68.55 (n)
  • 71.96 (a)
mvp 37
  • 68 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6610 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 69 (a)
OneToOne
Species with no ortholog for MVP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MVP Gene

ENSEMBL:
Gene Tree for MVP (if available)
TreeFam:
Gene Tree for MVP (if available)

Paralogs for MVP Gene

No data available for Paralogs for MVP Gene

Variants for MVP Gene

Sequence variations from dbSNP and Humsavar for MVP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1050809 -- 29,846,185(+) ACTGC(A/C)AAGGC synonymous-codon, reference
rs1050839 -- 29,847,830(+) AACCT(C/T)TTCAA reference, synonymous-codon
rs1050849 -- 29,847,886(+) GGGCA(A/G)AAGGG missense, reference
rs1063541 -- 29,840,390(+) GTGGT(C/G)CAGGA frameshift-variant, reference
rs1131328 -- 29,845,963(+) TTTTG(A/G)AGCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MVP Gene

Variant ID Type Subtype PubMed ID
nsv833186 CNV Loss 17160897
nsv827611 CNV Gain 20364138
nsv518568 CNV Gain 19592680
esv33498 CNV Gain 17666407

Relevant External Links for MVP Gene

HapMap Linkage Disequilibrium report
MVP

Disorders for MVP Gene

(70) Novoseek inferred disease relationships for MVP Gene

Disease -log(P) Hits PubMed IDs
secondary aml 67.9 2
ovarian carcinoma 56.5 21
nsclc 56.4 47
lymphoblastic leukemia acute childhood 54.9 9
acute leukemia 54.7 20

Relevant External Links for MVP

Human Genome Epidemiology (HuGE) Navigator
MVP
genes like me logo Genes that share disorders with MVP: view

No data available for UniProtKB/Swiss-Prot for MVP Gene

Publications for MVP Gene

  1. The drug resistance-related protein LRP is the human major vault protein. (PMID: 7585126) Scheffer G.L. … Scheper R.J. (Nat. Med. 1995) 2 3 4 23
  2. PTEN associates with the vault particles in HeLa cells. (PMID: 12177006) Yu Z. … Shen S.-H. (J. Biol. Chem. 2002) 3 4 23
  3. Cloning and initial analysis of the human multidrug resistance- related MVP/LRP gene promoter. (PMID: 11071864) Lange C. … Stein U. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. (PMID: 15133037) Kolli S. … Bennett A.M. (J. Biol. Chem. 2004) 3 4 23
  5. Solution structure of a two-repeat fragment of major vault protein. (PMID: 16373071) Kozlov G. … Ekiel I. (J. Mol. Biol. 2006) 3 4 23

Products for MVP Gene

Sources for MVP Gene

Back to Top

Content