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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MVP Gene

protein-coding GIFtS: 56
GCID: GC16P029831

major vault protein

Explore 81 diseases affiliated with
MVP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Major Vault Protein¹ ²
LRP¹ ² ³ ⁵
VAULT1¹ ²
Lung Resistance-Related Protein² ³

External Ids:	HGNC: 7531¹	Entrez Gene: 9961²	Ensembl: ENSG00000013364⁷	OMIM: 605088⁵	UniProtKB: Q14764³

Export aliases for MVP gene to outside databases

Previous GC identifers: GC16M029301 GC16P030151 GC16P029826 GC16P029869 GC16P029739 GC16P027492 GC16P029832

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MVP:

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that

may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by

regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also

plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of

cancer. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764

Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for

proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates

INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP

kinases

Gene Wiki entry for MVP (Major vault protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MVP gene promoter:
p53 AP-1 ATF-2 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MVP promoter sequence

Search SABiosciences Chromatin IP Primers for MVP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MVP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

MVP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MVP gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P029831: view genomic region (about GC identifiers)

Start:	29,831,715 bp from pter	End:	29,859,355 bp from pter
Size:	27,641 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764 (See protein sequence)

Recommended Name: Major vault protein

Size: 893 amino acids; 99327 Da

Subunit: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a

dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or

more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein

interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540

Subcellular location: Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates

from the nucleus to the cytoplasm upon EGF treatment

1 PDB 3D structure from and Proteopedia for MVP:

1Y7X (3D)

Secondary accessions: Q96BG4 Q9BPW6 Q9BQT1 Q9UBD1

Explore the universe of human proteins at neXtProt for MVP: NX_Q14764

Post-translational modifications:

Phosphorylated on Tyr residues after EGF stimulation¹

Dephosphorylated by PTPN11¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14764

MVP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005106.2 NP_059447.2

ENSEMBL proteins:

ENSP00000455819 ENSP00000349977 ENSP00000455741 ENSP00000455186 ENSP00000457734

ENSP00000454825 ENSP00000455532 ENSP00000454819 ENSP00000456291 ENSP00000457685

ENSP00000458583 ENSP00000378760 ENSP00000387916

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): MVP OriGene Protein Over-expression Lysate: MVP OriGene Custom Protein Services for MVP
	GenScript Custom Purified and Recombinant Proteins Services for MVP
	Novus Biologicals MVP Protein Novus Biologicals MVP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MVP

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	7585126
GO:0005643	nuclear pore	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0030529	ribonucleoprotein complex	IEA	--
GO:0043231	intracellular membrane-bounded organelle	--	--

MVP for ontologies About GeneDecksing

MVP Antibody Products:

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	Novus Biologicals MVP Antibodies
	Abcam antibodies for MVP
	Uscn Antibodies for MVP
	ThermoFisher Antibody for MVP

Assay Products for MVP:

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	GenScript Custom Assay Services for MVP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MVP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MVP for domains About GeneDecksing

2 InterPro domains/families:

IPR002499 Vault_N

IPR021870 MVP_shoulder

Graphical View of Domain Structure for InterPro Entry Q14764

ProtoNet protein and cluster: Q14764

1 Blocks protein family: IPB002499 Major vault protein

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764

Domain: MVP 3 mediates interaction with PTEN

Domain: MVP 4 mediates interaction with PARP4

Similarity: Contains 9 MVP (vault) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764

Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for

proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates

INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP

kinases

Induction: Up-regulated by IFNG/IFN-gamma

Genatlas biochemistry entry for MVP:

major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory functions,overexpressed in

acute myeloid leukemia resistant to chemotherapy

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MVP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MVP
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MVP:
		hsa-miR-365
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MVP (see all 7) OriGene shRNA RFP: MVP OriGene siRNA: MVP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MVP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MVP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MVP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MVP (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MVP (NM_005115)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MVP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MVP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MVP
		Search LifeMap BioReagents cell lines for MVP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVP

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18809583

MVP for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for MVP:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Mvp^tm1Wie for MVP
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mvp):

normal

MVP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MVP

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/761 Interacting proteins for MVP (Q14764^{2, 3} ENSP00000349977⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 761)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RANBP2	P49792²^,³	MINT-7945693 MINT-7947479 I2D: score=2
PARP4	Q9UKK3²^,³, ENSP00000371419⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000371419
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3319945 I2D: score=1 STRING: ENSP00000309503
KPNA2	P52292², ENSP00000332455⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000332455

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--
GO:0042493	response to drug	TAS	7585126
GO:0051028	mRNA transport	IEA	--

MVP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MVP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MVP
10/44 Novoseek chemical compound relationships for MVP gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
daunorubicin	73.3	33	10602424 (5), 9639420 (2), 9490695 (1), 10651723 (1) (see all 16)
rhodamine 123	71.7	5	15301712 (2), 9029025 (1), 15065906 (1)
doxorubicin	70.3	40	10511592 (3), 11774257 (2), 9436635 (2), 10764626 (2) (see all 23)
vincristine	63.4	17	10695015 (2), 10511592 (2), 12553062 (2), 9490695 (1) (see all 11)
etoposide	61.4	11	10511592 (2), 12553062 (2), 9713513 (1), 11791127 (1) (see all 8)
mitoxantrone	60.5	8	10468850 (2), 10050716 (1), 11697502 (1), 8630412 (1) (see all 5)
adriamycin	60.3	12	17497289 (2), 17075973 (2), 12576456 (1), 11149411 (1) (see all 8)
gramicidin d	57.4	5	10695015 (2), 10511592 (2), 11791127 (1)
paclitaxel	54.9	12	10695015 (2), 10511592 (2), 12963129 (1), 16465425 (1) (see all 6)
cisplatin	54.9	32	15547764 (4), 12520742 (3), 9713513 (2), 11372415 (2) (see all 14)

Search CenterWatch for drugs/clinical trials and news about MVP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MVP gene (2 alternative transcripts):

NM_005115.4 NM_017458.3

Unigene Cluster for MVP:

Major vault protein

Hs.632177 [show with all ESTs]

Unigene Representative Sequence: NM_017458

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000563915 ENST00000357402(uc010bzh.2 uc010vdz.2 uc002dui.3 uc002duj.3 uc010vea.2)

ENST00000566859 ENST00000563096 ENST00000566066 ENST00000562463 ENST00000563558

ENST00000565830 ENST00000569887 ENST00000565164 ENST00000570234 ENST00000566252

ENST00000566554 ENST00000569612 ENST00000563123 ENST00000570061 ENST00000568068

ENST00000395353

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MVP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MVP
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MVP:
		hsa-miR-365
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MVP (see all 7) OriGene shRNA RFP: MVP OriGene siRNA: MVP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MVP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MVP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MVP (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MVP (NM_005115)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MVP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MVP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MVP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MVP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MVP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MVP

Additional cDNA sequence:

AJ291366.1 AJ291367.1 AK293302.1 AK298238.1 AK301130.1 AK302052.1 AK310168.1 BC008932.2

BC015623.2 X79882.2

21 DOTS entries:

DT.447005 DT.97860371 DT.100889100 DT.95323263 DT.120696056 DT.102842026 DT.120697200 DT.120697395

DT.95075658 DT.100889060 DT.120697711 DT.91766041 DT.120696341 DT.120696679 DT.120696707 DT.120697278

DT.91743313 DT.100761599 DT.102841987 DT.120695267 DT.120695851

24/667 AceView cDNA sequences (see all 667):

AI523098 BM716307 BQ181875 AW105674 CR592692 BQ941322 BQ650453 AI927317

BE733509 AU156014 AL540890 AW103894 CF124957 BF964921 BM767293 BM979911

CR619145 BQ672010 CA392950 BM712429 AI076864 AW327313 BQ948009 CR616503

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for MVP (see all 17) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^
SP1:					-		-		-		-		-										-														-		-		-		-
SP2:					-		-		-		-												-
SP3:					-		-		-		-		-		-								-
SP4:					-		-		-		-								-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:					-		-				-		-										-

ExUns:	13a	·	13b	^	14	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21
SP1:	-
SP2:
SP3:
SP4:	-
SP5:

ECgene alternative splicing isoforms for MVP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MVP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGTGGAGA

About this image

MVP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Stylopod Long Bone

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MVP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MVP

SOURCE GeneReport for Unigene cluster: Hs.632177

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764

Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and

excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining

the intestine. Overexpressed in many multidrug-resistant cancer cells

SABiosciences Expression via Pathway-Focused PCR Arrays including MVP:

Drug Transporters in human mouse rat

Cancer Drug Resistance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MVP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MVP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MVP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MVP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MVP gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mvp^{1 , 5}	major vault protein^{1, 5}	86.62(n)¹ 91.83(a)¹		7 (69.26 cM)⁵ 78388¹ NM_080638.3¹ NP_542369.2¹ 126986860⁵
chicken (Gallus gallus)	Aves	MVP¹	major vault protein	70.31(n) 69.95(a)		420049 NM_001006336.1 NP_001006336.1
lizard (Anolis carolinensis)	Reptilia	MVP⁶	--	73(a)	1 ↔ 1	GL343279.1(248788-279648)
African clawed frog (Xenopus laevis)	Amphibia	MGC68839²	hypothetical protein MGC68839	76.31(n)		BC057708.1
zebrafish (Danio rerio)	Actinopterygii	mvp²	major vault protein	77.15(n)		373081 BC063949.1

ENSEMBL Gene Tree for MVP (if available)
TreeFam Gene Tree for MVP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60695042^1,2	F,	--	29829791(+)	`GCCACT/GGTCTT`	3	--	us2k¹ int¹		1		EA	120
rs7200638^1,2	C,F,H,	--	29829846(+)	`TCCAGT/CTTCTG`	3	--	int¹ us2k¹		18		NS EA WA NA CSA	1176
rs181333106^1,2		--	29829863(+)	`AGATGA/GACCTT`	3	--	us2k¹ int¹		0	--	--	--	--
rs186508885^1,2		--	29830039(+)	`CACCAC/TGCCTA`	3	--	us2k¹ int¹		0	--	--	--	--
rs140854858^1,2		--	29830051(+)	`CTAATC/TTTTGT`	3	--	us2k¹ int¹		0	--	--	--	--
rs191770981^1,2		--	29830098(+)	`AGGCTA/GGTCTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs79506175^1,2		--	29830225(+)	`TCCAAC/GGGATT`	3	--	int¹ us2k¹		0	--	--	--	--
rs183133187^1,2		--	29830271(+)	`CCAAGC/TGCTTT`	3	--	us2k¹ int¹		0	--	--	--	--
rs138838753^1,2		--	29830305(+)	`ACTCTC/TTTTTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs186177931^1,2		--	29830350(+)	`GTAGCA/TGTGTC`	3	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MVP (29831715 - 29859355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MVP
4 CNVs: 88059 35383 77273 88058
1 Indel: 11110

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MVP for disorders           About GeneDecksing

OMIM gene information: 605088    OMIM disorders: --

20/81 diseases for MVP (see all 81):    About MalaCards

diffuse large b-cell lymphoma dysembryoplastic neuroepithelial tumor fibrous histiocytoma non-small cell lung carcinoma

b-cell lymphomas malignant fibrous histiocytoma non-hodgkin lymphoma soft tissue sarcoma

myxoid liposarcoma lymphoblastic leukemia liposarcoma histiocytoma

epithelioid sarcoma esophageal squamous cell carcinoma cystic fibrosis squamous cell carcinoma

benign tumors carcinoma hodgkin's lymphoma adult t-cell leukemia

10/70 Novoseek disease relationships for MVP gene (see all 70) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
secondary aml	67.9	3	11167822 (1), 9592977 (1)
ovarian carcinoma	56.5	22	10767994 (5), 7563169 (4), 11277644 (2), 12216079 (2) (see all 12)
nsclc	56.4	68	8879378 (6), 11718033 (5), 12824911 (4), 19875192 (4) (see all 23)
lymphoblastic leukemia acute childhood	54.9	10	16019505 (1), 12153178 (1), 10602424 (1), 15543372 (1) (see all 9)
acute leukemia	54.7	31	16045016 (4), 17538395 (3), 11798719 (2), 16086885 (2) (see all 12)
leukemia	53.8	34	9778689 (2), 9490695 (2), 9029025 (2), 10792272 (2) (see all 16)
tumors	51.2	120	15154630 (5), 19660100 (5), 11585860 (3), 19900859 (3) (see all 64)
aml childhood	51.1	5	18228020 (1), 20426950 (1), 16086885 (1)
carcinoma non-small cell lung	48.3	7	9436635 (2), 11718033 (1), 11791127 (1)
lymphoblastic leukemia acute	48.3	8	15543372 (3), 9490695 (1), 12860010 (1), 16086885 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: MVP (18 documents)

Export disorders for MVP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MVP gene, integrated from 9 sources (see all 393):
(articles sorted by number of sources associating them with MVP)

Utopia: connect your pdf to the dynamic
world of online information

The drug resistance-related protein LRP is the human major vault protein. (PubMed id 7585126)^{1, 2, 3, 9} Scheffer G.L.... Scheper R.J. (1995)
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. (PubMed id 16441665)^{1, 2, 9} Kim E....Suh P.-G. (2006)
The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. (PubMed id 16418217)^{1, 2, 9} Steiner E.... Berger W. (2006)
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. (PubMed id 15133037)^{1, 2, 9} Kolli S.... Bennett A.M. (2004)
PTEN associates with the vault particles in HeLa cells. (PubMed id 12177006)^{1, 2, 9} Yu Z....Shen S.-H. (2002)
Solution structure of a two-repeat fragment of major vault protein. (PubMed id 16373071)^{1, 2, 9} Kozlov G....Ekiel I. (2006)
Cloning and initial analysis of the human multidrug resistance- related MVP/LRP gene promoter. (PubMed id 11071864)^{1, 2, 9} Lange C.... Stein U. (2000)
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. (PubMed id 18809583)^{1, 2} Chattopadhyay R....Bhakat K.K. (2008)
A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway. (PubMed id 16815308)^{1, 2} Xiang Z....Li Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9961	HGNC: 7531	AceView: MVPandMGC4606andLOC112476	Ensembl:ENSG00000013364	euGenes: HUgn9961
ECgene: MVP	H-InvDB: MVP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MVP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MVP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MVP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MVP gene:
Search GeneIP for patents involving MVP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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major vault protein

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MVP Gene

major vault protein

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