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MVP Gene

protein-coding   GIFtS: 59
GCID: GC16P029831

Major Vault Protein

  See MVP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Vault Protein1 2
Lung Resistance-Related Protein1 2 3
LRP2 3 5
VAULT12

External Ids:    HGNC: 75311   Entrez Gene: 99612   Ensembl: ENSG000000133647   OMIM: 6050885   UniProtKB: Q147643   

Export aliases for MVP gene to outside databases

Previous GC identifers: GC16M029301 GC16P030151 GC16P029826 GC16P029869 GC16P029739 GC16P027492 GC16P029832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MVP Gene:
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures
that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular
processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The
encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker
for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
(provided by RefSeq, May 2012)

GeneCards Summary for MVP Gene:
MVP (major vault protein) is a protein-coding gene. Diseases associated with MVP include mitral valve prolapse, myxomatous 1, and mesial temporal lobe epilepsy with hippocampal sclerosis. GO annotations related to this gene include protein phosphatase binding and protein kinase binding.

UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764
Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for
proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.
Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and
signaling through MAP kinases

Gene Wiki entry for MVP (Major vault protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MVP gene promoter:
         p53   AP-1   ATF-2   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMVP promoter sequence
   Search Chromatin IP Primers for MVP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MVP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

MVP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MVP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029831:  view genomic region     (about GC identifiers)

Start:
29,831,715 bp from pter      End:
29,859,360 bp from pter
Size:
27,646 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764 (See protein sequence)
Recommended Name: Major vault protein  
Size: 893 amino acids; 99327 Da
Subunit: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of
a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and
one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated
protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540
1 PDB 3D structure from and Proteopedia for MVP:
1Y7X (3D)    
Secondary accessions: Q96BG4 Q9BPW6 Q9BQT1 Q9UBD1

Explore the universe of human proteins at neXtProt for MVP: NX_Q14764

Explore proteomics data for MVP at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr residues after EGF stimulation1
  • Dephosphorylated by PTPN111
  • Ubiquitination2 at Lys444, Lys674, Lys747
  • Modification sites at PhosphoSitePlus

  • See MVP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005106.2  NP_059447.2  

    ENSEMBL proteins: 
     ENSP00000455819   ENSP00000349977   ENSP00000455741   ENSP00000455186   ENSP00000457734  
     ENSP00000454825   ENSP00000455532   ENSP00000454819   ENSP00000456291   ENSP00000457685  
     ENSP00000458583   ENSP00000378760   ENSP00000387916  

    MVP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MVP
    OriGene Protein Over-expression Lysate for MVP
    OriGene MassSpec for MVP
    OriGene Custom Protein Services for MVP
    GenScript Custom Purified and Recombinant Proteins Services for MVP
    Novus Biologicals MVP Protein
    Novus Biologicals MVP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MVP

     
    Search eBioscience for Proteins for MVP 

    MVP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MVP
    OriGene Custom Antibody Services for MVP
    Novus Biologicals MVP Antibodies
    Abcam antibodies for MVP
    Cloud-Clone Corp. Antibodies for MVP
    ThermoFisher Antibody for MVP
    LSBio Antibodies in human, mouse, rat for MVP

    MVP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MVP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MVP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MVP
    Cloud-Clone Corp. CLIAs for MVP
    Search eBioscience for ELISAs for MVP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002499 Vault_N
     IPR021870 MVP_shoulder

    Graphical View of Domain Structure for InterPro Entry Q14764

    ProtoNet protein and cluster: Q14764

    1 Blocks protein domain: IPB002499 Major vault protein

    UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764
    Domain: MVP 3 mediates interaction with PTEN
    Domain: MVP 4 mediates interaction with PARP4
    Similarity: Contains 9 MVP (vault) repeats


    Find genes that share domains with MVP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MVP_HUMAN, Q14764
    Function: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for
    proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.
    Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and
    signaling through MAP kinases
    Induction: Up-regulated by IFNG/IFN-gamma

         Genatlas biochemistry entry for MVP:
    major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory
    functions,overexpressed in acute myeloid leukemia resistant to chemotherapy

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15133037
    GO:0019901protein kinase binding IPI16441665
    GO:0019903protein phosphatase binding IDA15133037
         
    Find genes that share ontologies with MVP           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MVP:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mvp):
     normal 

    Find genes that share phenotypes with MVP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mvptm1Wie for MVP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MVP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MVP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MVP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MVP

    miRNA
    Products:
        
    miRTarBase miRNAs that target MVP:
    hsa-mir-124-3p (MIRT022129)

    Block miRNA regulation of human, mouse, rat MVP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MVP:
    hsa-miR-365
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MVP
    Predesigned siRNA for gene silencing in human, mouse, rat MVP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MVP

    Clone
    Products:
         
    OriGene clones in human, mouse for MVP (see all 12)
    OriGene ORF clones in mouse, rat for MVP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MVP (NM_005115)
    Sino Biological Human cDNA Clone for MVP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MVP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MVP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MVP
    Browse ESI BIO Cell Lines and PureStem Progenitors for MVP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MVP_HUMAN, Q14764: Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex.
    Translocates from the nucleus to the cytoplasm upon EGF treatment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15133037
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IDA16441665
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with MVP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including MVP: 
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MVP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for MVP (Q147642, 3 ENSP000003499774) via UniProtKB, MINT, STRING, and/or I2D (see all 797)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP2P497922, 3MINT-7945693 MINT-7947479 I2D: score=2 
    PARP4Q9UKK32, 3, ENSP000003714194MINT-7945693 I2D: score=3 STRING: ENSP00000371419
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    YWHAZP631042, 3, ENSP000003095034MINT-3319945 I2D: score=1 STRING: ENSP00000309503
    KPNA2P522922, ENSP000003324554MINT-7945693 MINT-7947479 STRING: ENSP00000332455
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation IEA--
    GO:0015031protein transport IEA--
    GO:0023057negative regulation of signaling IDA16441665
    GO:0031953negative regulation of protein autophosphorylation IDA16441665
    GO:0038127ERBB signaling pathway IDA15133037

    Find genes that share ontologies with MVP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MVP

    Selected Novoseek inferred chemical compound relationships for MVP gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    daunorubicin 73.3 33 10602424 (5), 9639420 (2), 9490695 (1), 10651723 (1) (see all 16)
    rhodamine 123 71.7 5 15301712 (2), 9029025 (1), 15065906 (1)
    doxorubicin 70.3 40 10511592 (3), 11774257 (2), 9436635 (2), 10764626 (2) (see all 23)
    vincristine 63.4 17 10695015 (2), 10511592 (2), 12553062 (2), 9490695 (1) (see all 11)
    etoposide 61.4 11 10511592 (2), 12553062 (2), 9713513 (1), 11791127 (1) (see all 8)
    mitoxantrone 60.5 8 10468850 (2), 10050716 (1), 11697502 (1), 8630412 (1) (see all 5)
    adriamycin 60.3 12 17497289 (2), 17075973 (2), 12576456 (1), 11149411 (1) (see all 8)
    gramicidin d 57.4 5 10695015 (2), 10511592 (2), 11791127 (1)
    paclitaxel 54.9 12 10695015 (2), 10511592 (2), 12963129 (1), 16465425 (1) (see all 6)
    cisplatin 54.9 32 15547764 (4), 12520742 (3), 9713513 (2), 11372415 (2) (see all 14)



    Find genes that share compounds with MVP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MVP gene (2 alternative transcripts): 
    NM_005115.4  NM_017458.3  

    Unigene Cluster for MVP:

    Major vault protein
    Hs.632177  [show with all ESTs]
    Unigene Representative Sequence: NM_017458
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000563915 ENST00000357402(uc010bzh.2 uc010vdz.2 uc002dui.3 uc002duj.3 uc010vea.2)
    ENST00000566859 ENST00000563096 ENST00000566066 ENST00000562463 ENST00000563558
    ENST00000565830 ENST00000569887 ENST00000565164 ENST00000570234 ENST00000566252
    ENST00000566554 ENST00000569612 ENST00000563123 ENST00000570061 ENST00000568068
    ENST00000395353
    miRNA
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    Block miRNA regulation of human, mouse, rat MVP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MVP:
    hsa-miR-365
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MVP
    Predesigned siRNA for gene silencing in human, mouse, rat MVP
    Clone
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    OriGene clones in human, mouse for MVP (see all 12)
    OriGene ORF clones in mouse, rat for MVP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MVP (NM_005115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MVP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MVP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MVP
    OriGene qSTAR qPCR primer pairs in human, mouse for MVP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MVP
      QuantiTect SYBR Green Assays in human, mouse, rat MVP
      QuantiFast Probe-based Assays in human, mouse, rat MVP

    Additional mRNA sequence: 

    AJ291366.1 AJ291367.1 AK293302.1 AK298238.1 AK301130.1 AK302052.1 AK310168.1 BC008932.2 
    BC015623.2 X79882.2 

    21 DOTS entries:

    DT.447005  DT.97860371  DT.100889100  DT.95323263  DT.120696056  DT.102842026  DT.120697200  DT.120697395 
    DT.95075658  DT.100889060  DT.120697711  DT.91766041  DT.120696341  DT.120696679  DT.120696707  DT.120697278 
    DT.91743313  DT.100761599  DT.102841987  DT.120695267  DT.120695851 

    Selected AceView cDNA sequences (see all 667):

    CR622842 AU122322 BI917216 AI553932 CD108314 BQ948009 BM979911 BM712429 
    CA392950 CR610997 BQ889169 AW103894 AI927317 CR616503 BQ670133 CA395698 
    BQ650453 AL540890 BQ941322 AW105674 BE733509 CR592692 AU156014 CF124957 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MVP (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
    SP1:              -     -     -     -     -                             -                                         -     -     -     -                           
    SP2:              -     -     -     -                                   -                                                                                       
    SP3:              -     -     -     -     -     -                       -                                                                                       
    SP4:              -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP5:              -     -           -     -                             -                                                                                       

    ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
    SP1:  -                                                                                 
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:  -                                                                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MVP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MVP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGGAGA
    MVP Expression
    About this image


    MVP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone Marrow
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MVP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MVP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632177

    UniProtKB/Swiss-Prot: MVP_HUMAN, Q14764
    Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory
    and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and
    cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MVP: 
              Drug Transporters in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MVP
    OriGene qSTAR qPCR primer pairs in human, mouse for MVP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MVP
    QuantiTect SYBR Green Assays in human, mouse, rat MVP
    QuantiFast Probe-based Assays in human, mouse, rat MVP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MVP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mvp1 , 5 major vault protein1, 5 86.62(n)1
    91.83(a)1
      7 (69.26 cM)5
    783881  NM_080638.31  NP_542369.21 
     1269868605 
    chicken
    (Gallus gallus)
    Aves MVP1 major vault protein 70.31(n)
    69.95(a)
      420049  NM_001006336.1  NP_001006336.1 
    lizard
    (Anolis carolinensis)
    Reptilia MVP6
    major vault protein
    72(a)
    1 ↔ 1
    GL343279.1(241237-281131)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688392 hypothetical protein MGC68839 76.31(n)    BC057708.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mvp2 major vault protein 77.15(n)   373081  BC063949.1 


    ENSEMBL Gene Tree for MVP (if available)
    TreeFam Gene Tree for MVP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MVP (see all 604)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462011041,2
    --29834327(+) GCGCCC/TGGCCT 2 -- int10--------
    rs735283551,2
    C--29834328(+) CGCCCG/AGCCTG 2 -- int12Minor allele frequency- A:0.03WA 120
    rs3684475491,2
    C--29834443(+) CTTTTC/TTTTTT 2 -- int10--------
    rs665129161,2
    C--29834444(+) TTTTTT/-TTTTT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs360450021,2
    C--29834475(-) AAGAG-/AGTGAGG 2 -- int10--------
    rs1859105511,2
    --29834697(+) CTCCCA/GTCTTG 2 -- int10--------
    rs620563711,2
    C,F--29834954(+) CGGATT/CACGAG 2 -- int13Minor allele frequency- C:0.33NA 6
    rs1908251171,2
    --29835122(+) CGTGCA/CACTGC 2 -- int10--------
    rs1439874841,2
    --29835152(+) AGCGAA/GACTCG 2 -- int10--------
    rs1451329071,2
    --29835157(+) GACTCA/GTCTCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for MVP (29831715 - 29859360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MVP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833186CNV Loss17160897
    nsv518568CNV Gain19592680
    nsv827611CNV Gain20364138
    esv33498CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MVP
    DNA2.0 Custom Variant and Variant Library Synthesis for MVP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605088    OMIM disorders: --

    4 diseases for MVP:    
    About MalaCards
    mitral valve prolapse, myxomatous 1    mesial temporal lobe epilepsy with hippocampal sclerosis    frontal lobe epilepsy    acute myeloid leukemia


    Find genes that share disorders with MVP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MVP gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    secondary aml 67.9 3 11167822 (1), 9592977 (1)
    ovarian carcinoma 56.5 22 10767994 (5), 7563169 (4), 11277644 (2), 12216079 (2) (see all 12)
    nsclc 56.4 68 8879378 (6), 11718033 (5), 12824911 (4), 19875192 (4) (see all 23)
    lymphoblastic leukemia acute childhood 54.9 10 16019505 (1), 12153178 (1), 10602424 (1), 15543372 (1) (see all 9)
    acute leukemia 54.7 31 16045016 (4), 17538395 (3), 11798719 (2), 16086885 (2) (see all 12)
    leukemia 53.8 34 9778689 (2), 9490695 (2), 9029025 (2), 10792272 (2) (see all 16)
    tumors 51.2 120 15154630 (5), 19660100 (5), 11585860 (3), 19900859 (3) (see all 64)
    aml childhood 51.1 5 18228020 (1), 20426950 (1), 16086885 (1)
    carcinoma non-small cell lung 48.3 7 9436635 (2), 11718033 (1), 11791127 (1)
    lymphoblastic leukemia acute 48.3 8 15543372 (3), 9490695 (1), 12860010 (1), 16086885 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: MVP (18 documents)

    Export disorders for MVP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MVP gene, integrated from 10 sources (see all 404):
    (articles sorted by number of sources associating them with MVP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The drug resistance-related protein LRP is the human major vault protein. (PubMed id 7585126)1, 2, 3, 9 Scheffer G.L.... Scheper R.J. (Nat. Med. 1995)
    2. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. (PubMed id 16441665)1, 2, 9 Kim E....Suh P.-G. (FEBS J. 2006)
    3. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. (PubMed id 16418217)1, 2, 9 Steiner E.... Berger W. (J. Cell Sci. 2006)
    4. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. (PubMed id 15133037)1, 2, 9 Kolli S.... Bennett A.M. (J. Biol. Chem. 2004)
    5. PTEN associates with the vault particles in HeLa cells. (PubMed id 12177006)1, 2, 9 Yu Z....Shen S.-H. (J. Biol. Chem. 2002)
    6. Solution structure of a two-repeat fragment of major vault protein. (PubMed id 16373071)1, 2, 9 Kozlov G....Ekiel I. (J. Mol. Biol. 2006)
    7. Cloning and initial analysis of the human multidrug resistance- related MVP/LRP gene promoter. (PubMed id 11071864)1, 2, 9 Lange C.... Stein U. (Biochem. Biophys. Res. Commun. 2000)
    8. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1- mediated activation of the multidrug resistance gene MDR1. (PubMed id 18809583)1, 2 Chattopadhyay R.... Bhakat K.K. (Mol. Cell. Biol. 2008)
    9. A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway. (PubMed id 16815308)1, 2 Xiang Z.... Li Y. (Biochem. Biophys. Res. Commun. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9961 HGNC: 7531 AceView: MVPandMGC4606andLOC112476 Ensembl:ENSG00000013364 euGenes: HUgn9961
    ECgene: MVP H-InvDB: MVP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MVP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MVP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MVP gene:
    Search GeneIP for patents involving MVP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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