External Ids for MVP Gene
Previous GeneCards Identifiers for MVP Gene
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for MVP Gene
MVP (Major Vault Protein) is a Protein Coding gene. Diseases associated with MVP include mesial temporal lobe epilepsy with hippocampal sclerosis and core binding factor acute myeloid leukemia. GO annotations related to this gene include protein kinase binding and protein phosphatase binding.
UniProtKB/Swiss-Prot for MVP Gene
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.