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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MVD Gene

protein-coding GIFtS: 60
GCID: GC16M088718

mevalonate (diphospho) decarboxylase

Explore 8 diseases affiliated with
MVD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mevalonate (Diphospho) Decarboxylase¹ ²		FP17780²
MPD¹ ² ³		Diphosphomevalonate Decarboxylase²
Mevalonate Pyrophosphate Decarboxylase² ³		EC 4.1.1.33³
MDDase² ³		Mevalonate (Diphospho)Decarboxylase³

External Ids:	HGNC: 7529¹	Entrez Gene: 4597²	Ensembl: ENSG00000167508⁷	OMIM: 603236⁵	UniProtKB: P53602³

Export aliases for MVD gene to outside databases

Previous GC identifers: GC16M080154 GC16M089686 GC16M088421 GC16M088462 GC16M087245 GC16M074412

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MVD:

The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl

pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate

while hydrolyzing ATP. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602

Function: Performs the first committed step in the biosynthesis of isoprenes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010542.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MVD gene promoter:
AhR PPAR-alpha Pax-5 Sp1 AP-1 p53 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MVD promoter sequence

Search SABiosciences Chromatin IP Primers for MVD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MVD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3

MVD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MVD gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M088718: view genomic region (about GC identifiers)

Start:	88,718,343 bp from pter	End:	88,729,569 bp from pter
Size:	11,227 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602 (See protein sequence)

Recommended Name: Diphosphomevalonate decarboxylase

Size: 400 amino acids; 43405 Da

Subunit: Homodimer

1 PDB 3D structure from and Proteopedia for MVD:

3D4J (3D)

Secondary accessions: Q53Y65

Explore the universe of human proteins at neXtProt for MVD: NX_P53602

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53602

MVD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002452.1

ENSEMBL proteins:

ENSP00000301012 ENSP00000455131 ENSP00000458049 ENSP00000455602 ENSP00000456465

Reactome Protein details: P53602
Human Recombinant Protein Products:

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	Uscn Proteins for MVD

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005777	NOT peroxisome	IDA	14972328
GO:0005782	peroxisomal matrix	--	--
GO:0005829	cytosol	TAS	--

MVD for ontologies About GeneDecksing

MVD Antibody Products:

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Assay Products for MVD:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for MVD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MVD for domains About GeneDecksing

4 InterPro domains/families:

IPR006204 GHMP_kinase_N_dom

IPR005935 Mev_diP_decarb

IPR020568 Ribosomal_S5_D2-typ_fold

IPR014721 Ribosomal_S5_D2-typ_fold_subgr

Graphical View of Domain Structure for InterPro Entry P53602

ProtoNet protein and cluster: P53602

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602

Similarity: Belongs to the diphosphomevalonate decarboxylase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602

Function: Performs the first committed step in the biosynthesis of isoprenes

Catalytic activity: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)

Biophysicochemical properties: Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate; KM=0.32 mM for ATP;

Enzyme Number (IUBMB): EC 4.1.1.33¹

miRNA Products:		OriGene 3'-UTR Clone: MVD Browse MicroRNA Expression Plasmids
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MVD
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVD

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004163	diphosphomevalonate decarboxylase activity	TAS	--
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	--	--
GO:0030544	Hsp70 protein binding	IPI	12646231
GO:0042803	protein homodimerization activity	IDA	8626466

MVD for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MVD:

Decreased Hepatitis C virus re

Animal Models:
1 MGI phenotypic allele

for Mvd (no phenotypes)

MVD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	1.00			Terpenoid backbone biosynthesis	0.71
	mevalonate pathway I	0.86

Cholesterol biosynthesis

	Cholesterol biosynthesis	1.00			Cholesterol Biosynthesis	0.68
	superpathway of cholesterol biosynthesis	0.81

Expression of ELOVL6

Expression of Diphosphomevalonate Decarboxylase (MVD)

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

5 BioSystems Pathways for MVD

	SREBP signalling
	Cholesterol Biosynthesis
	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	superpathway of cholesterol biosynthesis
	mevalonate pathway I

5/6 Reactome Pathways for MVD (see all 6)

	Metabolism
	Cholesterol biosynthesis
	Expression of Diphosphomevalonate Decarboxylase (MVD)
	Activation of Gene Expression by SREBP (SREBF)
	Metabolism of lipids and lipoproteins

2 Kegg Pathways (Kegg details for MVD):

	Terpenoid backbone biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602

Pathway: Steroid biosynthesis; cholesterol biosynthesis

MVD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MVD

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/83 Interacting proteins for MVD (P53602^{2, 3} ENSP00000301012⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 83)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	TAS	--
GO:0008284	positive regulation of cell proliferation	IMP	9270019
GO:0008299	isoprenoid biosynthetic process	IDA	11792727
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	--	--
GO:0042493	response to drug	--	--

MVD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MVD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MVD

7 HMDB Compounds for MVD About this table

Compound	Synonyms	CAS #	PubMed Ids
(R)-Mevalonic acid-5-pyrophosphate	1,1,3,7-tetrahydroxy-7-methyl-2,4-Dioxa-1,3-diphosphanonan-9-oic acid 1,3-dioxide (see all 15)	1492-08-6	--
5-Diphosphomevalonic acid	(R)-5-Diphosphomevalonate (see all 9)	--	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
Isopentenyl pyrophosphate	3-Methyl-3-butenyl pyrophosphate (see all 13)	358-71-4	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--

8 Novoseek chemical compound relationships for MVD gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mevalonate pyrophosphate	98.2	18	14972328 (3), 8626466 (2), 7947744 (2), 9600263 (1) (see all 9)
6-fluoromevalonate	95.4	4	7712482 (1), 9270019 (1)
phosphomevalonate	93.2	3	14680974 (1), 11188689 (1), 19485344 (1)
mevalonate	83.7	9	7712482 (1), 9270019 (1), 14680974 (1), 11188689 (1) (see all 7)
isopentenyl diphosphate	81.9	1	14680974 (1)
lovastatin	76.4	4	9270019 (1), 9600263 (1), 15166627 (1)
sterol	52.3	1	10344201 (1)
cholesterol	34	3	8626466 (1), 15166627 (1), 15994924 (1)

Search CenterWatch for drugs/clinical trials and news about MVD / MVD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MVD gene:

NM_002461.1

Unigene Cluster for MVD:

Mevalonate (diphospho) decarboxylase

Hs.252457 [show with all ESTs]

Unigene Representative Sequence: AB209229

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565149(uc002flf.1) ENST00000301012(uc002flg.1) ENST00000562981

ENST00000561895 ENST00000569177 ENST00000567064 ENST00000568133 ENST00000563785

ENST00000568709 ENST00000563170 ENST00000566636 ENST00000565720 ENST00000562651

ENST00000565610 ENST00000563463 ENST00000562741 ENST00000565842

miRNA Products:		OriGene 3'-UTR Clone: MVD Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MVD
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MVD

Additional cDNA sequence:

AB209229.1 AY203927.1 BC000011.2 BT006930.1 U49260.1

14 DOTS entries:

DT.87016603 DT.75135260 DT.95087273 DT.100807303 DT.97847795 DT.95151588 DT.95151587 DT.101975975

DT.95151590 DT.100807305 DT.100807311 DT.102830477 DT.120668778 DT.120668799

24/268 AceView cDNA sequences (see all 268):

BM904107 AW075275 BU539564 BU538505 T09119 BQ710385 BM910669 AW103760

BF589947 CD674084 BF058316 AI201391 BX458350 CA775934 BI759022 BQ641769

BX340321 BI825999 AI658536 BQ956062 AI864951 BM823763 AI336835 BX331219

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for MVD (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·
SP1:													-		-		-		-		-		-		-								-		-						-		-		-
SP2:													-		-		-						-		-								-		-						-		-		-
SP3:													-		-		-		-		-		-		-								-		-								-		-
SP4:													-				-		-		-		-		-								-		-						-		-		-
SP5:													-		-		-						-		-								-		-						-		-		-

ExUns:	13b	·	13c	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18
SP1:			-
SP2:			-
SP3:			-
SP4:			-
SP5:

ECgene alternative splicing isoforms for MVD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MVD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAATAAAC

About this image
See MVD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MVD

SOURCE GeneReport for Unigene cluster: Hs.252457

UniProtKB/Swiss-Prot: MVD1_HUMAN, P53602

Tissue specificity: Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta

SABiosciences Expression via Pathway-Focused PCR Array including MVD:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MVD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MVD gene from 10/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mvd^{1 , 5}	mevalonate (diphospho) decarboxylase^{1, 5}	82.7(n)¹ 84.63(a)¹		8 (71.05 cM)⁵ 192156¹ NM_138656.2¹ NP_619597.2¹ 122433596⁵
chicken (Gallus gallus)	Aves	MVD¹	mevalonate (diphospho) decarboxylase	73.35(n) 72.34(a)		425359 XM_423130.3 XP_423130.3
lizard (Anolis carolinensis)	Reptilia	MVD⁶	--	68(a)	1 ↔ 1	GL343670.1(114376-128760)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC394871²	hypothetical protein LOC394871	75.54(n)		BC063907.1
zebrafish (Danio rerio)	Actinopterygii	zgc:100824¹	zgc:100824	65.47(n) 67.52(a)		492781 NM_001007422.1 NP_001007423.1
fruit fly (Drosophila melanogaster)	Insecta	CG8239^{1 , 3}	diphosphomevalonate decarboxylase³ CG8239¹	48(a)³ 54.27(n)¹ 50.66(a)¹		13E14³ 32520¹ NM_132840.4¹ NP_573068.3¹
worm (Caenorhabditis elegans)	Secernentea	Y48B6A.13b³	--	40(a) (best of 2)		II(14220908-14226145) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MVD1(YNR043W)⁴ MVD1¹	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer less⁴ Mvd1p¹	48.99(n)¹ 48.82(a)¹		14(701895-703085)⁴ 855779^{1, 4} NP_014441.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G54250¹	diphosphomevalonate decarboxylase	52.79(n) 53.05(a)		824592 NM_115285.2 NP_566995.1
rice (Oryza sativa)	Liliopsida	Os.10543²	Transcribed sequence with moderate similarity to protein refNP_181404.1 (A.thaliana) mevalonate diphosphate decarboxylase [Arabidopsis thaliana] less	75.21(n)		CB622472.1

ENSEMBL Gene Tree for MVD (if available)
TreeFam Gene Tree for MVD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79171831^1,2	F,	--	74413633(+)	`GACACG/AGTAGG`	1	--	int¹		1		WA	118
rs74033340^1,2	C,	--	74413974(+)	`GAGACG/AGCAGG`	1	--	int¹		3		WA EA	240
rs8046018^1,2	C,H,	--	74414011(+)	`TAGGGG/TTGATG`	1	--	int¹		3		WA NA	240
rs59632581^1,2		--	74414095(+)	`GCTCTC/TGAATG`	1	--	int¹		1		WA	118
rs34653770^1,2	C,F,	--	74414247(+)	`CTGCAG/AAACAG`	1	--	int¹		3		NA	6
rs112789103^1,2		--	74414253(+)	`AACAGC/TGGAAG`	1	--	int¹		2		CSA WA	120
rs7205348^1,2	C,A,	--	74414630(+)	`CATGGC/GGGCTC`	1	--	int¹		0	--	--	--	--
rs74033341^1,2	C,	--	74414815(+)	`GCAGGC/TGTGTT`	1	--	int¹		2		WA	120
rs112548744^1,2		--	74414855(+)	`CCTGCG/AGGGTC`	1	--	int¹		1		CSA	2
rs7201080^1,2	C,A	--	74414900(+)	`GGAGAC/TCCTGG`	1	--	int¹		2		NA	4

HapMap Linkage Disequilibrium report for MVD (88718343 - 88729569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MVD
2 CNVs: 4973 30011

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MVD for disorders           About GeneDecksing

OMIM gene information: 603236    OMIM disorders: --

8 diseases for MVD:    About MalaCards

3-methylglutaconic aciduria cholesterol adrenoleukodystrophy pancreatic carcinoma

pancreatitis glioblastoma pneumonia carcinoma

Human Genome Epidemiology (HuGE) Navigator: MVD (19 documents)

Export disorders for MVD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MVD gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MVD)

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Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. (PubMed id 8626466)^{1, 2, 3, 9} Toth M.J. and Huwyler L. (1996)
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. (PubMed id 18823933)^{1, 2} Voynova N.E....Miziorko H.M. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human mevalonate pyrophosphate decarboxylase is localized in the cytosol. (PubMed id 14972328)^{1, 9} Hogenboom S....Waterham H.R. (2004)
Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. (PubMed id 14680974)^{1, 9} Hogenboom S....Waterham H.R. (2003)
Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism. (PubMed id 9270019)^{1, 9} Cuthbert J.A. and Lipsky P.E. (1997)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4597	HGNC: 7529	AceView: MVD	Ensembl:ENSG00000167508	euGenes: HUgn4597
ECgene: MVD	Kegg: 4597	H-InvDB: MVD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MVD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MVD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MVD gene:
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GeneCards and IP:
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