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Aliases for MVD Gene

Aliases for MVD Gene

  • Mevalonate (Diphospho) Decarboxylase 2 3
  • Mevalonate Pyrophosphate Decarboxylase 2 3 4
  • MDDase 3 4
  • MPD 3 4
  • Mevalonate (Diphospho)Decarboxylase 4
  • EC 4.1.1.33 4
  • FP17780 3

External Ids for MVD Gene

Previous GeneCards Identifiers for MVD Gene

  • GC16M080154
  • GC16M089686
  • GC16M088421
  • GC16M088462
  • GC16M087245
  • GC16M088718
  • GC16M074412

Summaries for MVD Gene

Entrez Gene Summary for MVD Gene

  • The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

GeneCards Summary for MVD Gene

MVD (Mevalonate (Diphospho) Decarboxylase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include protein homodimerization activity and Hsp70 protein binding.

UniProtKB/Swiss-Prot for MVD Gene

  • Performs the first committed step in the biosynthesis of isoprenes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MVD Gene

Genomics for MVD Gene

Regulatory Elements for MVD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MVD Gene

Chromosome:
16
Start:
88,651,935 bp from pter
End:
88,663,161 bp from pter
Size:
11,227 bases
Orientation:
Minus strand

Genomic View for MVD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MVD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MVD Gene

Proteins for MVD Gene

  • Protein details for MVD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53602-MVD1_HUMAN
    Recommended name:
    Diphosphomevalonate decarboxylase
    Protein Accession:
    P53602
    Secondary Accessions:
    • Q53Y65

    Protein attributes for MVD Gene

    Size:
    400 amino acids
    Molecular mass:
    43405 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MVD Gene

neXtProt entry for MVD Gene

Proteomics data for MVD Gene at MOPED

Post-translational modifications for MVD Gene

  • Ubiquitination at Lys 22, Lys 58, and Lys 179
  • Modification sites at PhosphoSitePlus

Other Protein References for MVD Gene

Antibody Products

No data available for DME Specific Peptides for MVD Gene

Domains & Families for MVD Gene

Gene Families for MVD Gene

Suggested Antigen Peptide Sequences for MVD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53602

UniProtKB/Swiss-Prot:

MVD1_HUMAN :
  • Belongs to the diphosphomevalonate decarboxylase family.
Family:
  • Belongs to the diphosphomevalonate decarboxylase family.
genes like me logo Genes that share domains with MVD: view

Function for MVD Gene

Molecular function for MVD Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate {ECO:0000269 PubMed:9392419}; KM=0.32 mM for ATP {ECO:0000269 PubMed:9392419};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
UniProtKB/Swiss-Prot Function:
Performs the first committed step in the biosynthesis of isoprenes

Enzyme Numbers (IUBMB) for MVD Gene

Gene Ontology (GO) - Molecular Function for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004163 diphosphomevalonate decarboxylase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016831 carboxy-lyase activity --
GO:0030544 Hsp70 protein binding IPI 12646231
GO:0042803 protein homodimerization activity IDA 8626466
genes like me logo Genes that share ontologies with MVD: view
genes like me logo Genes that share phenotypes with MVD: view

Animal Model Products

miRNA for MVD Gene

miRTarBase miRNAs that target MVD

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MVD

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MVD Gene

Localization for MVD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MVD Gene COMPARTMENTS Subcellular localization image for MVD gene
Compartment Confidence
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 NOT peroxisome IDA 14972328
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MVD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MVD Gene

Pathways & Interactions for MVD Gene

genes like me logo Genes that share pathways with MVD: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

UniProtKB/Swiss-Prot P53602-MVD1_HUMAN

  • Pathway: Steroid biosynthesis; cholesterol biosynthesis

Gene Ontology (GO) - Biological Process for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006489 dolichyl diphosphate biosynthetic process TAS --
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008284 positive regulation of cell proliferation IMP 9270019
GO:0008299 isoprenoid biosynthetic process IDA 11792727
genes like me logo Genes that share ontologies with MVD: view

No data available for SIGNOR curated interactions for MVD Gene

Drugs & Compounds for MVD Gene

(8) Drugs for MVD Gene - From: HMDB, IUPHAR, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 56
Isopentenyl pyrophosphate Experimental Pharma 0
cholesterol Experimental Pharma Agonist 0
6-fluoromevalonate 5-diphosphate Pharma Competitive, Inhibitor 0

(12) Additional Compounds for MVD Gene - From: HMDB, NovoSeek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
P-geranyl 2-fluoromevalonate 5-diphosphate
Competitive, Inhibitor
(R)-Mevalonic acid-5-pyrophosphate
  • (R)-5-Diphosphomevalonic acid
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-Dioxa-1,3-diphosphanonan-9-oate
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-Dioxa-1,3-diphosphanonan-9-oic acid
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-Dioxa-1,3-diphosphanonan-9-oic acid 1,3-dioxide
  • 5-Pyrophosphomevalonate
1492-08-6
(S)-5-Diphosphomevalonic acid
  • (S)-Mevalonic acid-5-pyrophosphate
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-oate
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-oic acid
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-oic acid ion(1-)1,3-dioxide
  • 5-Diphosphomevalonate
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
genes like me logo Genes that share compounds with MVD: view

Transcripts for MVD Gene

Unigene Clusters for MVD Gene

Mevalonate (diphospho) decarboxylase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MVD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MVD Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10:
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - -
SP16: - - - -
SP17: - - -
SP18: - - - -
SP19: - - -
SP20: -

ExUns: 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10: - -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:

Relevant External Links for MVD Gene

GeneLoc Exon Structure for
MVD
ECgene alternative splicing isoforms for
MVD

Expression for MVD Gene

mRNA expression in normal human tissues for MVD Gene

Protein differential expression in normal tissues from HIPED for MVD Gene

This gene is overexpressed in Fetal testis (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MVD Gene



SOURCE GeneReport for Unigene cluster for MVD Gene Hs.252457

mRNA Expression by UniProt/SwissProt for MVD Gene

P53602-MVD1_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.
genes like me logo Genes that share expression patterns with MVD: view

Protein tissue co-expression partners for MVD Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MVD Gene

Orthologs for MVD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MVD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MVD 35
  • 84.33 (n)
  • 83.5 (a)
MVD 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MVD 35
  • 85.25 (n)
  • 86.75 (a)
MVD 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mvd 35
  • 82.7 (n)
  • 84.63 (a)
Mvd 16
Mvd 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MVD 35
  • 99.33 (n)
  • 99.75 (a)
MVD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mvd 35
  • 83.38 (n)
  • 85.14 (a)
oppossum
(Monodelphis domestica)
Mammalia MVD 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MVD 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MVD 35
  • 73.35 (n)
  • 72.34 (a)
MVD 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MVD 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394871 35
mvd 35
  • 65.22 (n)
  • 68.88 (a)
zebrafish
(Danio rerio)
Actinopterygii mvda 35
  • 65.56 (n)
  • 67.52 (a)
mvda 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8239 37
  • 48 (a)
CG8239 35
  • 54.16 (n)
  • 50.39 (a)
CG8239 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001611 35
  • 57.05 (n)
  • 53.1 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48B6A.13a 37
  • 39 (a)
Y48B6A.13b 37
  • 40 (a)
Y48B6A.13 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL232C 35
  • 58.09 (n)
  • 52.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10285g 35
  • 50.13 (n)
  • 50.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MVD1 35
  • 49.09 (n)
  • 48.56 (a)
MVD1 36
  • 45 (a)
OneToOne
MVD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G54250 35
  • 52.79 (n)
  • 53.05 (a)
soybean
(Glycine max)
eudicotyledons Gma.7599 35
barley
(Hordeum vulgare)
Liliopsida Hv.5909 35
rice
(Oryza sativa)
Liliopsida Os.10543 35
Os02g0109100 35
  • 61.2 (n)
  • 56.56 (a)
corn
(Zea mays)
Liliopsida Zm.14376 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11381 35
  • 54.27 (n)
  • 51.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mvd1 35
  • 51.05 (n)
  • 50.79 (a)
Species with no ortholog for MVD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MVD Gene

ENSEMBL:
Gene Tree for MVD (if available)
TreeFam:
Gene Tree for MVD (if available)

Paralogs for MVD Gene

No data available for Paralogs for MVD Gene

Variants for MVD Gene

Sequence variations from dbSNP and Humsavar for MVD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11811 -- 88,654,725(-) TGTGT(G/T)GCACG reference, missense
rs868222 -- 88,658,276(+) GGGAG(C/G)CCCTG intron-variant
rs871166 -- 88,659,006(-) GCGAT(C/G)CGCAC intron-variant
rs899733 -- 88,658,321(+) GGCAC(A/G)TGTGT intron-variant
rs1017828 -- 88,654,203(-) CTTGG(C/G/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MVD Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv907264 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv1926 CNV Insertion 18451855
dgv2980n71 CNV Loss 21882294
nsv907283 CNV Loss 21882294
dgv2981n71 CNV Loss 21882294
nsv907288 CNV Loss 21882294
nsv471113 CNV Loss 18288195

Variation tolerance for MVD Gene

Residual Variation Intolerance Score: 75.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MVD Gene

HapMap Linkage Disequilibrium report
MVD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVD Gene

Disorders for MVD Gene

Relevant External Links for MVD

Genetic Association Database (GAD)
MVD
Human Genome Epidemiology (HuGE) Navigator
MVD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MVD
genes like me logo Genes that share disorders with MVD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MVD Gene

Publications for MVD Gene

  1. Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. (PMID: 8626466) Toth M.J. … Huwyler L. (J. Biol. Chem. 1996) 2 23 67
  2. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. (PMID: 20056424) Kudoh T. … Silverman R.B. (Bioorg. Med. Chem. 2010) 23 67
  3. d-I'-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. (PMID: 19346993) Hussein D. … Mo H. (Pancreas 2009) 23 67
  4. Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family. (PMID: 19485344) Andreassi J.L. … Leyh T.S. (Biochemistry 2009) 23 67
  5. Cholesterol biosynthesis modulation regulates dengue viral replication. (PMID: 19419745) Rothwell C. … Gaither L.A. (Virology 2009) 23 67

Products for MVD Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MVD
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MVD
    • Block miRNA regulation of MVD using miScript Target Protectors

    Sources for MVD Gene

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