Aliases for MVB12B Gene
External Ids for MVB12B Gene
Previous HGNC Symbols for MVB12B Gene
Previous GeneCards Identifiers for MVB12B Gene
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for MVB12B Gene
MVB12B (Multivesicular Body Subunit 12B) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include lipid binding and ubiquitin binding. An important paralog of this gene is MVB12A.
UniProtKB/Swiss-Prot for MVB12B Gene
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.