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MVB12B Gene

protein-coding   GIFtS: 44
GCID: GC09P129091

Multivesicular Body Subunit 12B

(Previous names: chromosome 9 open reading frame 28, family with sequence...)
(Previous symbols: C9orf28, FAM125B)
  See MVB12B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Multivesicular Body Subunit 12B1 2     ESCRT-I Complex Subunit MVB12B2 3
C9orf281 2 3     Chromosome 9 Open Reading Frame 281
FAM125B1 2 3     Protein FAM125B3
Family With Sequence Similarity 125, Member B1 2     

External Ids:    HGNC: 233681   Entrez Gene: 898532   Ensembl: ENSG000001968147   UniProtKB: Q9H7P63   

Export aliases for MVB12B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MVB12B Gene:
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the
sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays
an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related
protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12
subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for MVB12B Gene:
MVB12B (multivesicular body subunit 12B) is a protein-coding gene. Diseases associated with MVB12B include hiv-1. An important paralog of this gene is MVB12A.

UniProtKB/Swiss-Prot: MB12B_HUMAN, Q9H7P6
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
of endocytic ubiquitinated cargos into multivesicular bodies




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MVB12B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMVB12B promoter sequence
   Search Chromatin IP Primers for MVB12B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MVB12B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34.12

MVB12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MVB12B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P129091:  view genomic region     (about GC identifiers)

Start:
129,089,128 bp from pter      End:
129,269,320 bp from pter
Size:
180,193 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MB12B_HUMAN, Q9H7P6 (See protein sequence)
Recommended Name: Multivesicular body subunit 12B  
Size: 319 amino acids; 35620 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28.
Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts
with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex
Sequence caution: Sequence=BAB15722.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MVB12B:
3TOW (3D)    
Secondary accessions: Q8N6S7
Alternative splicing: 2 isoforms:  Q9H7P6-1   Q9H7P6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MVB12B: NX_Q9H7P6

Explore proteomics data for MVB12B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115
  • Modification sites at PhosphoSitePlus

  • See MVB12B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011703.1  NP_258257.1  

    ENSEMBL proteins: 
     ENSP00000354772   ENSP00000384751   ENSP00000441988   ENSP00000401379   ENSP00000442846  

    MVB12B Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for MVB12B (4 products) 

     
    antibodies-online peptides for MVB12B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018798 FAM125
     IPR023341 MABP
     IPR023340 UMA

    Graphical View of Domain Structure for InterPro Entry Q9H7P6

    ProtoNet protein and cluster: Q9H7P6

    UniProtKB/Swiss-Prot: MB12B_HUMAN, Q9H7P6
    Similarity: Belongs to the MVB12 family
    Similarity: Contains 1 MABP domain
    Similarity: Contains 1 UMA domain


    Find genes that share domains with MVB12B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MB12B_HUMAN, Q9H7P6
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008289lipid binding IMP--
    GO:0043130NOT ubiquitin binding IDA--
         
    Find genes that share ontologies with MVB12B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MVB12B:
     Decreased melanin production 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MVB12B

    miRNA
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    miRTarBase miRNAs that target MVB12B:
    hsa-mir-877-3p (MIRT036903)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MB12B_HUMAN, Q9H7P6: Endosome (Probable). Late endosome membrane; Peripheral membrane protein (Probable)

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005634nucleus IDA--
    GO:0005769early endosome IDA--
    GO:0005770late endosome IDA--
    GO:0005829cytosol IDA--

    Find genes that share ontologies with MVB12B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MVB12B About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis


    Find genes that share SuperPaths with MVB12B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MVB12B):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MVB12B
    Interactions:

        Search GeneGlobe Interaction Network for MVB12B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for MVB12B (Q9H7P63 ENSP000003547724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MVB12AQ96EY53, ENSP000003248104I2D: score=1 STRING: ENSP00000324810
    TSG101Q998163, ENSP000002519684I2D: score=1 STRING: ENSP00000251968
    VPS37AQ8NEZ23, ENSP000003186294I2D: score=1 STRING: ENSP00000318629
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CHMP4AENSP000003242054STRING: ENSP00000324205
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0042058regulation of epidermal growth factor receptor signaling pathway IMP--
    GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IC--

    Find genes that share ontologies with MVB12B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MVB12B (MB12B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MVB12B gene (2 alternative transcripts): 
    NM_001011703.2  NM_033446.2  

    Unigene Cluster for MVB12B:

    Multivesicular body subunit 12B
    Hs.162659  [show with all ESTs]
    Unigene Representative Sequence: NM_033446
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361171(uc004bqh.2 uc011lzy.2 uc010mxd.3) ENST00000489637(uc011lzz.1)
    ENST00000402437 ENST00000470567 ENST00000489570 ENST00000485886 ENST00000545391(uc004bqg.2)
    ENST00000436593 ENST00000535766
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MVB12B
      QuantiFast Probe-based Assays in human, mouse, rat MVB12B

    Additional mRNA sequence: 

    AJ420437.1 AK000001.1 AK024432.1 AK024441.1 AK293740.1 AK298023.1 AK307473.1 BC000122.1 
    BC028675.1 BC036326.1 BC041601.1 

    14 DOTS entries:

    DT.100818934  DT.100693448  DT.313820  DT.100818926  DT.121158582  DT.91665094  DT.100035840  DT.121158610 
    DT.75104188  DT.95269077  DT.100704547  DT.95088209  DT.95113146  DT.95269079 

    Selected AceView cDNA sequences (see all 173):

    AI360713 CN484922 AK000001 BU634142 BC041601 AA335641 AL524449 BM715654 
    BX116294 AW135337 AI912162 AI394447 CR615044 BM666174 BM716726 BM701249 
    F10294 BU618062 AA960833 BE207245 CD368622 AI589579 BI861956 BM674668 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MVB12B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:              -     -           -                                               -           -     -                           
    SP2:                                -                                                                                             
    SP3:              -     -           -                                                                                             
    SP4:                                                                    -     -     -           -     -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for MVB12B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MVB12B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MVB12B Expression
    About this image

    MVB12B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MVB12B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162659
        Custom PCR Arrays for MVB12B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MVB12B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mvb12b1 , 5 family with sequence similarity 125, member B5
    multivesicular body subunit 12B1
    89.17(n)1
    96.53(a)1
      2 (22.51 cM)5
    725431  NM_175184.41  NP_780393.21 
     337299535 
    chicken
    (Gallus gallus)
    Aves FAM125B1 family with sequence similarity 125, member B 79.67(n)
    86.76(a)
      417092  NM_001030677.1  NP_001025848.1 
    lizard
    (Anolis carolinensis)
    Reptilia MVB12B6
    multivesicular body subunit 12B
    81(a)
    1 ↔ 1
    GL343601.1(330353-384741)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323902 Xenopus laevis transcribed sequence with weak similarity more 77.25(n)    CF271139.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mvb12ba1 multivesicular body subunit 12Ba 72.62(n)
    82.86(a)
      767667  NM_001076606.1  NP_001070074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71926
    --
    19(a)
    1 → many
    X(17991591-17995356)
    worm
    (Caenorhabditis elegans)
    Secernentea mvb-121 mvb-12 42.95(n)
    30.43(a)
      182286  NM_068901.6  NP_501302.1 


    ENSEMBL Gene Tree for MVB12B (if available)
    TreeFam Gene Tree for MVB12B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MVB12B gene
    MVB12A2  
    2 SIMAP similar genes for MVB12B using alignment to 4 protein entries:     MB12B_HUMAN (see all proteins):
    FLJ00031    MVB12A

    Find genes that share paralogs with MVB12B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MVB12B (see all 3477)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913646911,2
    --98706557(+) GCTCCC/TGCCGC 2 -- ut510--------
    rs109872471,2
    C,F--98706797(+) CCAGCA/GGCGCC 2 -- int11Minor allele frequency- G:0.07NA 120
    rs1428495421,2
    C--98709826(+) TCTTT-/AC/   
      CTTTAC
    ACACA
    4 -- int1 cds10--------
    rs346696801,2
    C--98709851(+) CACAT-/AC/C  
      A
    /CATA
    ACACA
    2 -- int11NA 2
    rs722481601,2
    C--98713370(+) TTCATTCCATCCATCC
    ATCCATCCA
    /-
    TCCAT
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1430274891,2
    C--98713370(+) TTCAT-/TCCA  
            
    TCCAT
    2 -- int10--------
    rs341415101,2
    C--98730979(+) CTCTT-/T/TT  
            
    TTTTT
    2 -- int11NA 2
    rs576719411,2
    C--98764356(+) TTTTT-/T/TT  
            
    GAGAC
    2 -- int11NA 2
    rs360305971,2
    C--98783452(+) AAATC-/T/TTT 
            
    TTTTT
    2 -- int1 cds10--------
    rs1400228971,2
    C--98788617(+) ATTGT-/GGGGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MVB12B (129089128 - 129269320 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MVB12B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MVB12B
    DNA2.0 Custom Variant and Variant Library Synthesis for MVB12B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MVB12B:    
    About MalaCards
    hiv-1


    Find genes that share disorders with MVB12B           About GenesLikeMe


    Export disorders for MVB12B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MVB12B gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MVB12B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PubMed id 18005716)1, 2, 3 Morita E....Sundquist W.I. (Cell Host Microbe 2007)
    2. Structural basis for membrane targeting by the MVB12-associated I^-prism domain of the human ESCRT-I MVB12 subunit. (PubMed id 22232651)1, 3 Boura E. and Hurley J.H. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. (PubMed id 20654576)1, 3 Tsunematsu T....Konishi H. (Biochem. Biophys. Res. Commun. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding. (PubMed id 23895345)1 Sette P....Bouamr F. (Retrovirology 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89853 HGNC: 23368 AceView: C9orf28 Ensembl:ENSG00000196814 euGenes: HUgn89853
    ECgene: MVB12B Kegg: 89853 H-InvDB: MVB12B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MVB12B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MVB12B gene:
    Search GeneIP for patents involving MVB12B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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