Aliases for MUTYH Gene
External Ids for MUTYH Gene
Previous GeneCards Identifiers for MUTYH Gene
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MUTYH Gene
MUTYH (MutY DNA Glycosylase) is a Protein Coding gene. Diseases associated with MUTYH include attenuated familial adenomatous polyposis and mutyh-associated polyposis. Among its related pathways are DNA Damage and DNA Double-Strand Break Repair. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on glycosyl bonds.
UniProtKB/Swiss-Prot for MUTYH Gene
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.