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MUTYH Gene

protein-coding GIFtS: 65

GC01M045567

mutY homolog (E. coli)
(Previous name: mutY (E. coli) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CYP2C ^²
EC 3.2.2.- ^³
MGC4416 ^²
MYH ^¹, ², ³, ⁵
OTTHUMP00000009096 ^²
OTTHUMP00000009098 ^²
OTTHUMP00000009101 ^²
OTTHUMP00000009102 ^²
hMYH ^³

Descriptions
A/G-specific adenine DNA glycosylase ^²
MutY homolog ^², ³
mutY (E. coli) homolog ^¹
mutY homolog (E. coli) ^²

External Ids
HGNC: 7527¹
Entrez Gene: 4595²
UniProtKB: Q9UIF7³
Ensembl: ENSG00000132781⁷

Search outside databases for aliases for MUTYH gene

Previous GC identifers: GC01M045522 GC01M044795 GC01M045224 GC01M045208 GC01M045464

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MUTYH:

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises

adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine,

cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is

localized to the nucleus and mitochondria. Mutations in this gene result in heritable

predisposition to colon and stomach cancer. Multiple transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MUTYH_HUMAN, Q9UIF7

Function: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing

the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A

DNA glycosylase activities

Gene Wiki entry for MUTYH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MUTYH gene

Entrez Gene cytogenetic band: 1p34.3-p32.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1

MUTYH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M045567: (about GC identifiers)

Start:	45,567,501 bp from pter
End:	45,578,729 bp from pter
Size:	11,229 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MUTYH_HUMAN, Q9UIF7 (See protein sequence)

Recommended Name: A/G-specific adenine DNA glycosylase

Size: 546 amino acids; 60069 Da

Cofactor: Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but

which is probably involved in the proper positioning of the enzyme along the DNA strand (By

similarity)

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1X51 (3D)

Secondary accessions: Q15830 Q9UBP2 Q9UBS7 Q9UIF4 Q9UIF5 Q9UIF6

Alternative splicing: 7 isoforms: Q9UIF7-1 Q9UIF7-2 Q9UIF7-3 Q9UIF7-4 Q9UIF7-5 Q9UIF7-6 Q9UIF7-7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_001041636.1 NP_001041637.1 NP_001041638.1 NP_001041639.1 NP_001121897.1 NP_036354.1

ENSEMBL proteins:

ENSP00000361170 ENSP00000352239 ENSP00000361187 ENSP00000361182 ENSP00000346354 ENSP00000347685

ENSP00000361172 ENSP00000385401 ENSP00000361176

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MYH)
	Human Recombinant Proteins from Abnova (MUTYH)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	7823963
GO:0005654	nucleoplasm	EXP	10583946

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Antibodies for MUTYH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MUTYH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MYH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MUTYH)
	Novus Biologicals Antibodies for MUTYH

Assays for MUTYH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UIF7

ProtoNet protein and cluster: Q9UIF7

3 Blocks protein families:

IPB000086 NUDIX hydrolase

IPB004036 Endonuclease III

IPB011257 DNA glycosylase

UniProtKB/Swiss-Prot: MUTYH_HUMAN, Q9UIF7

Similarity: Belongs to the nth/mutY family

Similarity: Contains 1 nudix hydrolase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MUTYH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MUTYH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_012222

Applied Biosystems Silencer® siRNAs for MUTYH

Sigma-Aldrich siRNA and siRNA Panels for MUTYH

Sigma-Aldrich shRNA for MUTYH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MUTYH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001048171
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001048171
untagged cDNA clones in CMV expression vector (see all 7): NM_001048171

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001128425

UniProtKB/Swiss-Prot: MUTYH_HUMAN, Q9UIF7

Function: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing

the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A

DNA glycosylase activities

Enzyme Number (IUBMB): EC 3.2.2.-

Genatlas biochemistry entry for MUTYH:

mutY E coli homolog,involved in the repair of oxidative DNA damage

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mutyh):

life span-post-weaning/aging

tumorigenesis

5/12 Gene Ontology (GO) molecular function terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004519	endonuclease activity	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	11801590
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for MUTYH

5/20 Interacting proteins for MUTYH (ENSP00000352239³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCNA	ENSP00000368438³	STRING (score=.996)
MLH1	ENSP00000231790³	STRING (score=.989)
MSH6	ENSP00000234420³	STRING (score=.946)
MSH2	ENSP00000233146³	STRING (score=.926)
APEX1	ENSP00000216714³	STRING (score=.924)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006284	base-excision repair	IEA	--
GO:0006298	mismatch repair	TAS	7823963
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0008152	metabolic process	IEA	--
GO:0045007	depurination	EXP	10583946

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MUTYH
6 Novoseek chemical compound relationships for MUTYH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
af/ap	91.55	5	17489848 (3), 17524638 (1), 15623495 (1)
8-oxoguanine	81.40	5	15681617 (1), 15056851 (1), 17207658 (1), 15185308 (1) (see all 6)
8-hydroxyguanine	78.35	5	19300419 (1), 11121482 (1), 11295288 (1), 18271935 (1) (see all 5)
8-oxo-dg	43.91	1	18776649 (1)
pyrimidine	15.71	1	9611236 (1)
oxygen	12.24	3	19300419 (1), 14579148 (1), 15450125 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MUTYH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MUTYH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_012222

Sigma-Aldrich siRNA and siRNA Panels for MUTYH

Sigma-Aldrich shRNA for MUTYH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001048171 NM_001048172 NM_001048173 NM_001048174 NM_001128425 NM_012222

REFSEQ mRNAs for MUTYH gene (6 alternative transcripts):

NM_001048171.1 NM_001048172.1 NM_001048173.1 NM_001048174.1 NM_001128425.1 NM_012222.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001048171 NM_001048172 NM_001048173 NM_001048174 NM_001128425 NM_012222

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001048171
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001048171
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_001048171

Additional cDNA sequence:

AB025227.1 AB032920.1 AB032921.1 AB032922.1 AB032923.1 AB032924.1 AB032925.1 AB032926.1

AB032927.1 AB032928.1 AB032929.1 AK293830.1 BC003178.1 CR589986.1 CR601333.1

21 DOTS entries:

DT.100663185 DT.412280 DT.100663186 DT.92443341 DT.100663188 DT.95200981 DT.92443337 DT.100663191

DT.100873695 DT.100870054 DT.99938731 DT.100669115 DT.100848961 DT.92443327 DT.95200980 DT.95200984

DT.99955041 DT.100765377 DT.92008357 DT.92443342 DT.95298757

24/192 AceView cDNA sequences (see all 192 ):

BI818716 BG106259 BM479627 BQ427709 BG059970 AB032923 BM561672 BQ690261

BM720640 BC003178 BM845811 CR595712 AW498971 CB853480 AI536626 AB032921

CR617363 BQ689308 BM763584 BI755522 AL539243 CR589986 BF689856 BM457425

highest scoring ESTs for MUTYH:

AB032920 AB032921 AB032922 AB032923 AI929450 AW651674 BC003178 BE336787 BE794661 BG470140

Unigene Cluster for MUTYH:

MutY homolog (E. coli)

Hs.271353 [show with all ESTs]

Unigene Representative Sequence: NM_001128425

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MUTYH (see all 10 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14	^	15	^	16
SP1:
SP2:							-
SP3:																											-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MUTYH

9 Ensembl transcripts including schematic representations:

ENST00000372098 ENST00000359291 ENST00000372115 ENST00000372110 ENST00000354383 ENST00000355498

ENST00000372100 ENST00000401570 ENST00000372104

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MUTYH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MUTYH

¹ / ² / ³

7 probe-sets matching MUTYH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
489_at²^{, 3}	U95-A	1	1.00	1.00	0.04	1.04	U63329	0.20	1.00	0.72	1
490_g_at²^{, 3}	U95-A	1	1.00	1.00	0.05	1.23	U63329	0.20	1.00	0.72	1
1455_f_at²	U95-A	5	0.94	0.34	0.97	0.82	--	--	--	--	--
207727_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012222	0.60	1.00	0.82	1
216661_x_at²	U133-A	4	1.00	0.50	--	--	--	--	--	--	--
207727_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216661_x_at²	U133Plus2	4	1.00	0.50	--	--	--	--	--	--	--

GeneDecks MUTYH for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCAGCAAG

SOURCE GeneReport for Unigene cluster: Hs.271353
Expression variation in blood from EXPOLDB for MUTYH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MUTYH gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MUTYH¹	--	mutY homolog (E. coli)	84.65(n) 80.83(a)	482515 XM_539632.2 XP_539632.2
chimpanzee (Pan troglodytes)	MUTYH¹	--	mutY homolog (E. coli)	99.5(n) 99.25(a)	456539 XM_001155582.1 XP_001155582.1
cow (Bos taurus)	MUTYH¹	--	mutY homolog (E. coli)	84.98(n) 83.8(a)	513051 NM_001046135.1 NP_001039600.1
rat (Rattus norvegicus)	Mutyh¹	--	mutY homolog (E. coli)	81.62(n) 77.67(a)	170841 NM_133316.1 NP_579850.1
mouse (Mus musculus)	Mutyh^{1, 5}	4⁵	mutY homolog (E. coli)^{1, 5}	81.79(n)¹ 78.9(a)¹	70603¹ NM_133250.1¹ NP_573513.1¹ AA409964⁵ AA409965⁵ (see all 20)

About this table Species with no ortholog for MUTYH

ENSEMBL Gene Tree for MUTYH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in MUTYH are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3219489^1,2	A,C,F,H	45570092(-)	`GGACAG/CTGCCA`	6	H/Q	mis¹ ese³		17	NS EU EA WA MN CSAM	3144
	rs3219497^1,2	C,F,H	45567614(-)	`CTTTCG/AGTCTC`	6	Q/R	mis¹		9	NS EU EA WA	1010
	rs3219484^1,2	C,F,H	45572743(-)	`CAGCCA/GTGGGA`	6	V/M	mis¹ ese³		13	NS NA EU EA WA	1222
	rs3219496^1,2	F,H	45567630(-)	`AAGTCC/ATGGAT`	6	M/L	mis¹		4	NS EA WA	464
	rs35352891^1,2	F	45569988(-)	`CTCTGC/TCACCT`	6	A/V	mis¹		5	MN CSAM EA	408
	rs3219494^1,2	H	45568785(-)	`GCCAGG/AGACCT`	6	E/G	mis¹		5	NS EU EA WA	588
	rs1140507^1,2	H	45571713(-)	`TAAGCT/CGGTAC`	6	R/W	mis¹		4	EU EA WA	406
	rs11211096^1,2	C,H	45570328(+)	`GCTAAG/CAGCTG`	6	L/L	syn¹		9	MN CSAM EA EU WA	826
	rs3219487^1,2	A,C,F,H	45571142(-)	`GGAACG/AATAGA`	5	--	int¹		22	NS EA NA EU WA	3508
	rs3219483^1,2	C,F,H	45573785(-)	`GGAGCA/GGGACC`	5	--	int¹		14	NS EU EA WA NA	1398

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HapMap Linkage Disequilibrium images for MUTYH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604933 disorders: 608456 137215 132600

UniProtKB/Swiss-Prot: MUTYH_HUMAN, Q9UIF7

Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis

[MIM:608456]

Defects in MUTYH are a cause of gastric cancer [MIM:137215]

10/21 Novoseek disease relationships for MUTYH gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polyposis	92.85	75	15932553 (5), 16287072 (5), 18422726 (4), 16425850 (3) (see all 37)
familial adenomatous polyposis	89.56	43	19279422 (3), 16134147 (3), 15188161 (3), 18186383 (3) (see all 25)
adenoma	80.90	63	14999774 (3), 16890597 (3), 18515411 (3), 15366000 (3) (see all 38)
colorectal cancer	76.91	68	12707038 (4), 17931073 (3), 14991577 (3), 16941501 (3) (see all 31)
lynch syndrome	74.20	1	17335759 (1)
adenomatous polyps	72.35	3	16521226 (2), 17674103 (1)
germ-line mutation	70.23	8	18422726 (2), 16836001 (2), 16831587 (1), 16510566 (1) (see all 6)
microsatellite instability	68.28	4	17031395 (2), 17335759 (1), 16207212 (1)
polyps	61.97	13	17703316 (6), 15725711 (1), 14991577 (1), 17192888 (1) (see all 6)
somatic mutations	54.00	6	18022921 (2), 11295288 (2), 15273732 (1), 17219200 (1)

About this table

Human Gene Mutation Database: MUTYH
Genetic Association Database: MUTYH
Human Genome Epidemiology Navigator: MUTYH (49 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/168 PubMed articles for MUTYH gene (see all 168 ):

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas. (PubMed id 15366000)^{1, 3, 4, 6} Isidro G.... Boavida M.G. (2004)
Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. (PubMed id 10684930)^{1, 2, 3, 4} Ohtsubo T....Nakabeppu Y. (2000)
Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients. (PubMed id 16287072)^{1, 3, 6} Russell A.M....Heinimann K. (2006)
A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis. (PubMed id 16134146)^{1, 3, 6} Alhopuro P....Aaltonen L.A. (2005)
Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas. (PubMed id 14999774)^{1, 3, 6} Gismondi V....Varesco L. (2004)
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (PubMed id 15449173)^{1, 3, 6} Kim I.J....Park J.G. (2004)
Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations. (PubMed id 15761860)^{1, 3, 6} Kairupan C.F....Scott R.J. (2005)
Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer. (PubMed id 15943555)^{1, 3, 6} Zhou X.L....Lindblom A. (2005)
Genetic alterations of the MYH gene in gastric cancer. (PubMed id 15273732)^{1, 3, 4} Kim C.J.... Park W.S. (2004)
Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. (PubMed id 12853198)^{1, 3, 4} Sampson J.R.... Cheadle J.P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4595	HGNC: 7527	AceView: MUTYH	Ensembl:ENSG00000132781	euGenes: HUgn4595
ECgene: MUTYH	H-InvDB: MUTYH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MUTYH	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=MUTYH
NIEHS-SNPs	http://egp.gs.washington.edu/data/mutyh/

Licensable Technologies for MUTYH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MUTYH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MUTYH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MUTYH		Antibodies for MUTYH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MUTYH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MUTYH)
	Antibodies (MUTYH)
	Chimera RNAi (MUTYH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MYH)
	Antibodies (MYH)

Search OriGene for MUTYH

Search Tocris compounds for MUTYH

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MUTYH

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MUTYH Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MUTYH Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MUTYH

Summaries
for MUTYH

Genomic Location
for MUTYH

Proteins
for MUTYH

Protein Domains/
Families
for MUTYH

Gene Function
for MUTYH

Pathways & Interactions
for MUTYH

Drugs & Compounds
for MUTYH

Transcripts
for MUTYH

Expression
for MUTYH

Orthologs
for MUTYH

Paralogs
for MUTYH

SNPs/Variants
for MUTYH

Disorders & Mutations
for MUTYH

Medical News
for MUTYH

Publications
for MUTYH

Search for MUTYH

Genome Databases showing MUTYH

Other Databases showing MUTYH

Specialized Databases showing MUTYH

Licensable Technologies
for MUTYH

Services
for MUTYH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MUTYH Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MUTYH

Summariesfor MUTYH

Genomic Locationfor MUTYH

Proteinsfor MUTYH

Protein Domains/Familiesfor MUTYH

Gene Functionfor MUTYH

Pathways & Interactionsfor MUTYH

Drugs & Compoundsfor MUTYH

Transcriptsfor MUTYH

Expression for MUTYH

Orthologsfor MUTYH

Paralogsfor MUTYH

SNPs/Variantsfor MUTYH

Disorders & Mutationsfor MUTYH

Medical Newsfor MUTYH

Publicationsfor MUTYH

Search for MUTYH

Genome Databases showing MUTYH

Other Databases showing MUTYH

Specialized Databases showing MUTYH

Licensable Technologiesfor MUTYH

Servicesfor MUTYH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MUTYH

Summaries
for MUTYH

Genomic Location
for MUTYH

Proteins
for MUTYH

Protein Domains/
Families
for MUTYH

Gene Function
for MUTYH

Pathways & Interactions
for MUTYH

Drugs & Compounds
for MUTYH

Transcripts
for MUTYH

Expression
for MUTYH

Orthologs
for MUTYH

Paralogs
for MUTYH

SNPs/Variants
for MUTYH

Disorders & Mutations
for MUTYH

Medical News
for MUTYH

Publications
for MUTYH

Licensable Technologies
for MUTYH

Services
for MUTYH