MUSTN1 Gene
protein-coding GIFtS : 39
GCID: GC03 M052847
musculoskeletal, embryonic nuclear protein 1
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Aliasesfor MUSTN1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Musculoskeletal, Embryonic Nuclear Protein 1 1 2 Mustang1 MUSTANG2 Musculoskeletal Embryonic Nuclear Protein 12 Musculoskeletal Temporally Activated Novel2
Export aliases for MUSTN1 gene to outside databases Previous GC identifers: GC03M052825 GC03M052842
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Summariesfor MUSTN1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MSTN1_HUMAN, Q8IVN3 Function : May be involved in the development and regeneration of the musculoskeletal system (By similarity)
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Genomic Viewsfor MUSTN1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MUSTN1 gene promoter: c-Fos AP-2alpha isoform 3 AP-1 ATF-2 AP-2alpha isoform 4 AP-2alpha isoform 2 c-Jun AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for MUSTN1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUSTN1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.31 MUSTN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M052847: view genomic region
(about GC identifiers )
Start:
52,847,298 bp from pter
End:
52,874,278 bp from pter
Size:
26,981 bases
Orientation:
minus strand
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Proteinsfor MUSTN1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MSTN1_HUMAN, Q8IVN3 (See
protein sequence )Recommended Name: Musculoskeletal embryonic nuclear protein 1 Size : 82 amino acids; 8911 Da
Subcellular location : Nucleus (By similarity)Explore the universe of human proteins at neXtProt for MUSTN1: NX_Q8IVN3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IVN3 MUSTN1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_995325.3 ENSEMBL proteins: ENSP00000422253 ENSP00000421186 ENSP00000419877 ENSP00000410910 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005654 nucleoplasm
IEA --
MUSTN1 for ontologies About GeneDecksing MUSTN1 Antibody Products: Assay Products for MUSTN1:
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Protein
Domains / Familiesfor MUSTN1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q8IVN3
UniProtKB/Swiss-Prot: MSTN1_HUMAN, Q8IVN3 Similarity : Belongs to the MUSTANG family
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Functionfor MUSTN1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MSTN1_HUMAN, Q8IVN3 Function : May be involved in the development and regeneration of the musculoskeletal system (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MUSTN1 (NM_205853 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUSTN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MUSTN1
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Pathways & Interactionsfor MUSTN1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUSTN1 Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
MUSTN1 for ontologies About GeneDecksing
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Drugs & Compoundsfor MUSTN1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MUSTN1 Search CenterWatch for drugs/clinical trials and news about MUSTN1 / MSTN1
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Transcriptsfor MUSTN1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MUSTN1 gene: NM_205853.3 Unigene Cluster for MUSTN1:
Musculoskeletal, embryonic nuclear protein 1 Hs.556077 [show with all ESTs ] Unigene Representative Sequence: AK310752 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000468472 ENST00000513520 (uc010hmq.1 ) ENST00000486659 ENST00000495552 (uc003dga.4 )ENST00000446157 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MUSTN1 (NM_205853 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUSTN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MUSTN1
Additional cDNA sequence: AJ276556.1 AK309031.1 AK310752.1 BC130550.1 BC130552.1
10 DOTS entries : DT.442833 DT.100663232
DT.87046416 DT.308879 DT.99962947 DT.120911847 DT.120911849 DT.99965868 DT.40280441 DT.95191247 24/428 AceView cDNA sequences (see all 428 ):
H96309 BF969985 AV648742 CB163884 F27979 AV647813 BE909286 CR625639 CR614295 AL557947 CB161586 AI962765 CD614258 CB155974 AA346122 BI966873 CR591457 CR603484 AA723367 CB154334 AV647796 BM802543 NM_002218 AV653979 GeneLoc Exon Structure
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Expression for MUSTN1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MUSTN1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGAGAGTGTG
About this image MUSTN1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Primitive gut tube-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MUSTN1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MUSTN1 SOURCE GeneReport for Unigene cluster: Hs.556077 SABiosciences Custom PCR Arrays for MUSTN1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MUSTN1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MUSTN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MUSTN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MUSTN1
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Orthologsfor MUSTN1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MUSTN1 gene from 4/8 species (see all 8 ) About this table
ENSEMBL Gene Tree for MUSTN1 (if available)TreeFam Gene Tree for MUSTN1 (if available)
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Paralogsfor MUSTN1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MUSTN1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MUSTN1 (52847298 - 52874278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MUSTN1 1 CNV : 4339
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MUSTN1
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Disorders
/ Diseasesfor MUSTN1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MUSTN1 for disorders About GeneDecksing 4 diseases for MUSTN1 : About MalaCards hiatus hernia nevus enophthalmos hernia 2 diseases from the University of Copenhagen DISEASES database for MUSTN1 :Enophthalmos Methemoglobinemia Export disorders for MUSTN1 gene to outside databases
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Publicationsfor MUSTN1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MUSTN1 gene integrated from 9 sources : (articles sorted by number of sources associating them with MUSTN1) Utopia : connect your pdf to the dynamic world of online information
Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225) 1 Wolting C.D....McGlade C.J. (2011) Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972) 1 Sklar P....Purcell S.M. (2011) Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32. (PubMed id 17519359) 1 Kostek M.C....Rennie M.J. (2007) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 2 Muzny D.M....Gibbs R.A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during skeletal development and regeneration. (PubMed id 14718386) 1 Lombardo F....Hadjiargyrou M. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Silencing of Mustn1 inhibits myogenic fusion and diff erentiation. (PubMed id 20130207) 9 Liu C....Hadjiargyrou M. (2010)
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External Searches for MUSTN1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MUSTN1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MUSTN1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MUSTN1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MUSTN1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MUSTN1 gene: Search GeneIP for patents involving MUSTN1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MUSTN1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MUSTN1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MUSTN1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MUSTN1 OriGene Protein Over-expression Lysate for MUSTN1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MUSTN1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MUSTN1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MUSTN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MUSTN1 OriGene Custom Protein Services for MUSTN1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUSTN1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MUSTN1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUSTN1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MUSTN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MUSTN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MUSTN1
Search Tocris compounds for MUSTN1
MUSTN1 Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for MUSTN1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MUSTN1
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Databases for MUSTN1
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Genomic Views for MUSTN1
Intellectual Property for MUSTN1
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