Aliases for MUS81 Gene
External Ids for MUS81 Gene
Previous GeneCards Identifiers for MUS81 Gene
GeneCards Summary for MUS81 Gene
MUS81 (MUS81 Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with MUS81 include Congenital Hypoplastic Anemia and Fanconi Anemia, Complementation Group A. Among its related pathways are Fanconi anemia pathway and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include nuclease activity and 3-flap endonuclease activity.
UniProtKB/Swiss-Prot for MUS81 Gene
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5-end at the branch nick. Typical substrates include 3-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.