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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MURC Gene

protein-coding GIFtS: 43
GCID: GC09P103341

muscle-related coiled-coil protein

Explore 4 diseases affiliated with
MURC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Muscle-Related Coiled-Coil Protein¹ ²
CAVIN4¹ ²
Cavin-4¹
Muscle-Restricted Coiled-Coil Protein² ³

External Ids:	HGNC: 33742¹	Entrez Gene: 347273²	Ensembl: ENSG00000170681⁷	UniProtKB: Q5BKX8³

Export aliases for MURC gene to outside databases

Previous GC identifers: GC09P102381 GC09P072939

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MURC_HUMAN, Q5BKX8

Function: Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK

signaling pathway

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MURC gene promoter:
HFH-3 USF1 HTF FOXI1 MEF-2A HFH-1 USF-1 aMEF-2 Pax-4a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MURC promoter sequence

Search SABiosciences Chromatin IP Primers for MURC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MURC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.1

MURC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MURC gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P103341: view genomic region (about GC identifiers)

Start:	103,340,336 bp from pter	End:	103,350,188 bp from pter
Size:	9,853 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MURC_HUMAN, Q5BKX8 (See protein sequence)

Recommended Name: Muscle-related coiled-coil protein

Size: 364 amino acids; 41899 Da

Subunit: Interacts with SDPR; this augments the transactivation of NPPA

Subcellular location: Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm (By similarity). Note=In

cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely

throughout the cytoplasm (By similarity)

Sequence caution: Sequence=AAH90888.1; Type=Erroneous initiation;

Secondary accessions: B1PRL3 B4DT88

Explore the universe of human proteins at neXtProt for MURC: NX_Q5BKX8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5BKX8

MURC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001018126.1

ENSEMBL proteins:

ENSP00000418668

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0030018	Z disc	IEA	--

MURC for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MURC for domains About GeneDecksing

1 InterPro domain/family:

IPR026752 Cavin_fam

Graphical View of Domain Structure for InterPro Entry Q5BKX8

ProtoNet protein and cluster: Q5BKX8

UniProtKB/Swiss-Prot: MURC_HUMAN, Q5BKX8

Similarity: Belongs to the PTRF/SDPR family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MURC_HUMAN, Q5BKX8

Function: Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK

signaling pathway

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MURC

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007517	muscle organ development	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

MURC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for MURC gene:

NM_001018116.1

Unigene Cluster for MURC:

Muscle-related coiled-coil protein

Hs.99004 [show with all ESTs]

Unigene Representative Sequence: AK128238

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000307584(uc004bba.3)

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Additional cDNA sequence:

AK128238.1 AK300099.1 BC090888.1 EU487253.1

3 DOTS entries:

DT.454875 DT.101971746 DT.205907

20 AceView cDNA sequences:

AA446953 AA443378 BF061524 F28328 CF552121 AA679236 AJ707712 AA621376

Z28835 BX281689 F31738 W58229 BU101920 AA192639 W58230 AA192640

AJ709762 F22522 AW380047 BE092000

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MURC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCTGTCCC

About this image

MURC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MURC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MURC

SOURCE GeneReport for Unigene cluster: Hs.99004

SABiosciences Custom PCR Arrays for MURC

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MURC gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Murc^{1 , 5}	muscle-related coiled-coil protein^{1, 5}	81.95(n)¹ 83.15(a)¹		4 (26.23 cM)⁵ 68016¹ NM_026509.3¹ NP_080785.2¹ 48663514⁵
chicken (Gallus gallus)	Aves	MURC¹	muscle-related coiled-coil protein	65.51(n) 61.1(a)		420986 XM_419073.2 XP_419073.2
lizard (Anolis carolinensis)	Reptilia	MURC⁶	--	58(a)	1 ↔ 1	4(67814841-67830590)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23948²	Xenopus laevis transcribed sequence with weak similarity more	72.47(n)		BX847617.1
zebrafish (Danio rerio)	Actinopterygii	murc⁶ zgc:158664⁶	zgc:158664	41(a) 34(a)	many → 1 many → 1	24(34959506-34965880) 2(42292710-42299718)

ENSEMBL Gene Tree for MURC (if available)
TreeFam Gene Tree for MURC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MURC gene

PRKCDBP² PTRF² SDPR²

1 SIMAP similar gene for MURC using alignment to 1 protein entry: MURC_HUMAN:

PTRF

MURC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141589872^1,2	C,F,	--	103340482(+)	`CTGTCG/AAGTGT`	2	/S	syn¹		1		NA	4550
rs73657328^1,2	C,F,	--	103340658(+)	`ACAGTC/TGCATA`	2	S L	mis¹		3		WA NA	4670
rs146538761^1,2	C,F	--	103340659(+)	`CAGTCG/ACATAG`	2	/S	syn¹		2		NA EU	5849
rs149165620^1,2	C,F	--	103340668(+)	`AGCAAT/GACAGG`	2	/K /N	mis¹		1		NA	4548
rs191289133^1,2		--	103340706(+)	`AACCCA/GAAAAG`	2	Q R	mis¹		0	--	--	--	--
rs143268013^1,2	C,F	--	103340809(+)	`AAAAAC/GAAATT`	2	N K	mis¹		1		NA	4432
rs146923040^1,2	C,	--	103340816(+)	`AATTCC/TGCGTG`	2	R C	mis¹		1		NA	4372
rs137921742^1,2	C,F,	--	103340817(+)	`ATTCCG/ACGTGG`	2	/H /R	mis¹		2		NA EU	5664
rs182720808^1,2		--	103340820(+)	`CCGCGA/TGGTAA`	2	E V	mis¹		0	--	--	--	--
rs116000902^1,2	C,	--	103340839(+)	`GTAAGC/ATTGCA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MURC (103340336 - 103350188 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MURC: --
Human Gene Mutation Database (HGMD): MURC

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MURC for disorders About GeneDecksing

4 diseases for MURC: About MalaCards

diastolic heart failure familial dilated cardiomyopathy dilated cardiomyopathy cardiomyopathy

Export disorders for MURC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MURC gene integrated from 9 sources:
(articles sorted by number of sources associating them with MURC)

Utopia: connect your pdf to the dynamic
world of online information

MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. (PubMed id 18332105)^{1, 2, 3} Ogata T.... Oh H. (2008)
MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis. (PubMed id 18508909)^{1, 3} Tagawa M....Oh H. (2008)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Molecular genetic and functional characterization imp licate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy. (PubMed id 21642240)¹ Rodriguez G....Marian A.J. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)¹ Hillier L.D....Marra M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 347273	HGNC: 33742	AceView: LOC347273	Ensembl:ENSG00000170681	euGenes: HUgn347273
ECgene: MURC	H-InvDB: MURC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MURC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MURC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MURC gene:
Search GeneIP for patents involving MURC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MURC
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MURC
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MURC
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MURC
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MURC
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MURC

	GenScript Custom Purified and Recombinant Proteins Services for MURC		GenScript cDNA clones with any tag delivered in your preferred vector for MURC
	GenScript Custom Assay Services for MURC		GenScript Custom Superior Antibodies Services for MURC
	GenScript Custom overexpressing Cell Line Services for MURC		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Search for Antibodies for MURC at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for MURC
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MURC

	SwitchGear 3'UTR luciferase reporter plasmids for MURC
	SwitchGear Promoter luciferase reporter plasmids for MURC

ThermoFisher Antibodies for MURC

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MURC

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MURC gene at Home site.

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MURC Gene

muscle-related coiled-coil protein

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Export list of displayed genes

MURC Gene

muscle-related coiled-coil protein

Aliasesfor MURC gene

Summariesfor MURC gene

Genomic Viewsfor MURC gene

Proteinsfor MURC gene

Protein Domains /Familiesfor MURC gene

Functionfor MURC gene

Pathways & Interactionsfor MURC gene

Drugs & Compoundsfor MURC gene

Transcriptsfor MURC gene

Expression for MURC gene

Orthologsfor MURC gene

Paralogsfor MURC gene

Genomic Variantsfor MURC gene

Disorders / Diseasesfor MURC gene

Publicationsfor MURC gene

External Searches for MURC gene

Genome Databases showing MURC gene

Other Databases showing MURC gene

Specialized Databases showing MURC gene

Intellectual Propertyfor MURC gene

Productsfor MURC gene

View Random Gene

Aliases
for MURC gene

Summaries
for MURC gene

Genomic Views
for MURC gene

Proteins
for MURC gene

Protein Domains /
Families
for MURC gene

Function
for MURC gene

Pathways & Interactions
for MURC gene

Drugs & Compounds
for MURC gene

Transcripts
for MURC gene

Expression
for MURC gene

Orthologs
for MURC gene

Paralogs
for MURC gene

Genomic Variants
for MURC gene

Disorders / Diseases
for MURC gene

Publications
for MURC gene

Intellectual Property
for MURC gene

Products
for MURC gene