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Aliases for MUM1L1 Gene

Aliases for MUM1L1 Gene

  • MUM1 Like 1 2 3 5
  • Mutated Melanoma-Associated Antigen 1-Like Protein 1 4
  • Melanoma Associated Antigen (Mutated) 1-Like 1 2
  • MUM1-Like Protein 1 4

External Ids for MUM1L1 Gene

Previous GeneCards Identifiers for MUM1L1 Gene

  • GC0XP105218
  • GC0XP105412
  • GC0XP095038

Summaries for MUM1L1 Gene

Entrez Gene Summary for MUM1L1 Gene

  • This gene encodes a protein which contains a mutated melanoma-associated antigen 1 domain. Proteins which contain mutated antigens are expressed at high levels on certain types of cancers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for MUM1L1 Gene

MUM1L1 (MUM1 Like 1) is a Protein Coding gene. An important paralog of this gene is MUM1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUM1L1 Gene

Genomics for MUM1L1 Gene

Regulatory Elements for MUM1L1 Gene

Enhancers for MUM1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF105313 1.2 FANTOM5 Ensembl ENCODE 4.4 -853.9 -853905 2.2 ZNF146 STAT1 JUN CEBPB EP300 JUND STAT3 FOS NFE2L2 TCF7L2 MUM1L1 GC0XM105265 GC0XP105365
GH0XF106672 0.4 ENCODE 4.7 +504.4 504422 0.9 SCRT2 MUM1L1 PIR40777 GC0XP106640
GH0XF106170 0.4 ENCODE 0.8 +3.1 3091 1.8 CTCF RAD21 MUM1L1 GC0XP106229
GH0XF106168 0.4 ENCODE 0.8 0.0 -16 0.2 L3MBTL2 RNF2 MUM1L1 GC0XP106159
GH0XF106176 0.5 Ensembl ENCODE 0.4 +9.2 9168 1.5 MUM1L1 GC0XP106229
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MUM1L1 on UCSC Golden Path with GeneCards custom track

Promoters for MUM1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001918186 123 799 L3MBTL2 RNF2

Genomic Location for MUM1L1 Gene

106,168,278 bp from pter
106,208,961 bp from pter
40,684 bases
Plus strand

Genomic View for MUM1L1 Gene

Genes around MUM1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUM1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUM1L1 Gene

Proteins for MUM1L1 Gene

  • Protein details for MUM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PWWP domain-containing protein MUM1L1
    Protein Accession:
    Secondary Accessions:
    • D3DUX2
    • Q49AS5
    • Q8N2C0
    • Q96MT6

    Protein attributes for MUM1L1 Gene

    696 amino acids
    Molecular mass:
    79040 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31229.1; Type=Frameshift; Positions=406; Evidence={ECO:0000305}; Sequence=BAB71194.1; Type=Erroneous termination; Positions=638; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for MUM1L1 Gene

Post-translational modifications for MUM1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MUM1L1 Gene

No data available for DME Specific Peptides for MUM1L1 Gene

Domains & Families for MUM1L1 Gene

Gene Families for MUM1L1 Gene

Protein Domains for MUM1L1 Gene


Suggested Antigen Peptide Sequences for MUM1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PWWP domain.
  • Belongs to the MUM1 family.
  • Contains 1 PWWP domain.
  • Belongs to the MUM1 family.
genes like me logo Genes that share domains with MUM1L1: view

Function for MUM1L1 Gene

Phenotypes for MUM1L1 Gene

genes like me logo Genes that share phenotypes with MUM1L1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUM1L1 Gene

Localization for MUM1L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUM1L1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MUM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MUM1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MUM1L1 Gene

Pathways & Interactions for MUM1L1 Gene

SuperPathways for MUM1L1 Gene

No Data Available

Interacting Proteins for MUM1L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338641 for MUM1L1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MUM1L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MUM1L1 Gene

Transcripts for MUM1L1 Gene

Unigene Clusters for MUM1L1 Gene

Melanoma associated antigen (mutated) 1-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUM1L1 Gene

No ASD Table

Relevant External Links for MUM1L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUM1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MUM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUM1L1 Gene

This gene is overexpressed in Ovary (x20.0).

Protein differential expression in normal tissues from HIPED for MUM1L1 Gene

This gene is overexpressed in Ovary (54.4), Platelet (8.3), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUM1L1 Gene

Protein tissue co-expression partners for MUM1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MUM1L1 Gene:


SOURCE GeneReport for Unigene cluster for MUM1L1 Gene:

genes like me logo Genes that share expression patterns with MUM1L1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MUM1L1 Gene

Orthologs for MUM1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUM1L1 34 35
  • 99.38 (n)
(Canis familiaris)
Mammalia MUM1L1 34 35
  • 85.14 (n)
(Bos Taurus)
Mammalia MUM1L1 34 35
  • 84.49 (n)
(Rattus norvegicus)
Mammalia Mum1l1 34
  • 76.16 (n)
(Mus musculus)
Mammalia Mum1l1 34 16 35
  • 75.36 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
(Gallus gallus)
Aves -- 35
  • 29 (a)
(Danio rerio)
Actinopterygii MUM1L1 35
  • 16 (a)
Species where no ortholog for MUM1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUM1L1 Gene

Gene Tree for MUM1L1 (if available)
Gene Tree for MUM1L1 (if available)

Paralogs for MUM1L1 Gene

Paralogs for MUM1L1 Gene

(2) SIMAP similar genes for MUM1L1 Gene using alignment to 1 proteins: Pseudogenes for MUM1L1 Gene

genes like me logo Genes that share paralogs with MUM1L1: view

Variants for MUM1L1 Gene

Sequence variations from dbSNP and Humsavar for MUM1L1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11092557 -- 106,175,240(+) tcttt(C/T)ttttt intron-variant
rs111652658 -- 106,183,021(+) GCTGA(C/T)GGTCC intron-variant
rs111662064 -- 106,203,371(+) AGAAA(A/C)TTCTA intron-variant
rs111665949 -- 106,173,740(+) TTTTA(C/T)TATTG intron-variant
rs112055881 -- 106,173,818(+) GTGAC(C/T)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MUM1L1 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV gain 17911159
nsv521259 CNV gain 19592680

Variation tolerance for MUM1L1 Gene

Residual Variation Intolerance Score: 9.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUM1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUM1L1 Gene

Disorders for MUM1L1 Gene

Relevant External Links for MUM1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MUM1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUM1L1 Gene

Publications for MUM1L1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for MUM1L1 Gene

Sources for MUM1L1 Gene

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