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Aliases for MUL1 Gene

Aliases for MUL1 Gene

  • Mitochondrial E3 Ubiquitin Protein Ligase 1 2 3
  • Growth Inhibition And Death E3 Ligase 2 3 4
  • C1orf166 3 4 6
  • MULAN 3 4 6
  • Mitochondrial Ubiquitin Ligase Activator Of NFKB 1 2 3
  • Putative NF-Kappa-B-Activating Protein 266 3 4
  • Mitochondrial-Anchored Protein Ligase 3 4
  • Mitochondria-Anchored Protein Ligase 2 3
  • E3 Ubiquitin-Protein Ligase MUL1 3 4
  • E3 SUMO-Protein Ligase MUL1 3 4
  • Ring Finger Protein 218 2 3
  • RNF218 3 4
  • GIDE 3 4
  • MAPL 3 4
  • Mitochondrial Ubiquitin Ligase Activator Of NF-KB 3
  • Chromosome 1 Open Reading Frame 166 2
  • Mitochondrial E3 Ubiquitin Ligase 1 3
  • RING Finger Protein 218 4
  • E3 Ubiquitin Ligase 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for MUL1 Gene

Previous HGNC Symbols for MUL1 Gene

  • C1orf166

Previous GeneCards Identifiers for MUL1 Gene

  • GC01M020699
  • GC01M020825
  • GC01M019072

Summaries for MUL1 Gene

GeneCards Summary for MUL1 Gene

MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and signal transducer activity.

UniProtKB/Swiss-Prot for MUL1 Gene

  • Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at Lys-284 involving Lys-48-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUL1 Gene

Genomics for MUL1 Gene

Regulatory Elements for MUL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MUL1 Gene

Start:
20,499,448 bp from pter
End:
20,508,181 bp from pter
Size:
8,734 bases
Orientation:
Minus strand

Genomic View for MUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUL1 Gene

Proteins for MUL1 Gene

  • Protein details for MUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V5-MUL1_HUMAN
    Recommended name:
    Mitochondrial ubiquitin ligase activator of NFKB 1
    Protein Accession:
    Q969V5
    Secondary Accessions:
    • B5M497
    • Q7Z431
    • Q9H9B5

    Protein attributes for MUL1 Gene

    Size:
    352 amino acids
    Molecular mass:
    39800 Da
    Quaternary structure:
    • Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with MAVS.

neXtProt entry for MUL1 Gene

Proteomics data for MUL1 Gene at MOPED

Selected DME Specific Peptides for MUL1 Gene

Post-translational modifications for MUL1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys273
  • Modification sites at PhosphoSitePlus

Other Protein References for MUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for MUL1 Gene

Gene Families for MUL1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MUL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V5

UniProtKB/Swiss-Prot:

MUL1_HUMAN :
  • Q969V5
Domain:
  • The zinc finger domain is required for E3 ligase activity
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MUL1: view

Function for MUL1 Gene

Molecular function for MUL1 Gene

UniProtKB/Swiss-Prot Function:
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at Lys-284 involving Lys-48-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Enzyme Numbers (IUBMB) for MUL1 Gene

Gene Ontology (GO) - Molecular Function for MUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18213395
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MUL1: view

Phenotypes for MUL1 Gene

GenomeRNAi human phenotypes for MUL1:
genes like me logo Genes that share phenotypes with MUL1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MUL1 Gene

Localization for MUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUL1 Gene

Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUL1 Gene COMPARTMENTS Subcellular localization image for MUL1 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 4
cytosol 3
extracellular 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IMP 24898855
GO:0005777 peroxisome IDA 18207745
genes like me logo Genes that share ontologies with MUL1: view

Pathways for MUL1 Gene

SuperPathways for MUL1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q969V5-MUL1_HUMAN

  • Pathway: Protein modification; protein sumoylation
  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 18207745
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18591963
GO:0007005 mitochondrion organization --
GO:0007257 activation of JUN kinase activity IDA 18591963
GO:0010637 negative regulation of mitochondrial fusion IDA 19407830
genes like me logo Genes that share ontologies with MUL1: view

No data available for Pathways by source for MUL1 Gene

Transcripts for MUL1 Gene

mRNA/cDNA for MUL1 Gene

Unigene Clusters for MUL1 Gene

Mitochondrial E3 ubiquitin protein ligase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3: -

Relevant External Links for MUL1 Gene

GeneLoc Exon Structure for
MUL1
ECgene alternative splicing isoforms for
MUL1

Expression for MUL1 Gene

mRNA expression in normal human tissues for MUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MUL1 Gene

This gene is overexpressed in Lung (27.4), Testis (9.3), Placenta (8.2), and Fetal heart (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MUL1 Gene

SOURCE GeneReport for Unigene cluster for MUL1 Gene Hs.10101

mRNA Expression by UniProt/SwissProt for MUL1 Gene

Q969V5-MUL1_HUMAN
Tissue specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
genes like me logo Genes that share expressions with MUL1: view

Expression partners for MUL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MUL1 Gene

Orthologs for MUL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MUL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MUL1 35
  • 82.9 (n)
  • 83.38 (a)
MUL1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUL1 35
  • 90.15 (n)
  • 94.03 (a)
MUL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mul1 35
  • 86.93 (n)
  • 89.77 (a)
Mul1 16
Mul1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MUL1 35
  • 99.62 (n)
  • 99.72 (a)
MUL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mul1 35
  • 87.59 (n)
  • 90.06 (a)
oppossum
(Monodelphis domestica)
Mammalia MUL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUL1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MUL1 35
  • 73.39 (n)
  • 71.87 (a)
MUL1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUL1 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mul1 35
  • 67.05 (n)
  • 63.07 (a)
zebrafish
(Danio rerio)
Actinopterygii mul1b 35
  • 62.5 (n)
  • 61.65 (a)
mul1b 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mul1 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63900 35
  • 40.23 (n)
  • 31.66 (a)
rice
(Oryza sativa)
Liliopsida Os07g0647800 35
  • 41.15 (n)
  • 30.04 (a)
Species with no ortholog for MUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUL1 Gene

ENSEMBL:
Gene Tree for MUL1 (if available)
TreeFam:
Gene Tree for MUL1 (if available)

Paralogs for MUL1 Gene

No data available for Paralogs for MUL1 Gene

Variants for MUL1 Gene

Sequence variations from dbSNP and Humsavar for MUL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs501108 -- 20,509,143(+) cccgc(A/G)atcct upstream-variant-2KB
rs529974 -- 20,500,417(+) CACTC(A/G)CACTG utr-variant-3-prime
rs531651 -- 20,500,538(+) GAGGC(A/G)TGGGT utr-variant-3-prime
rs582984 -- 20,500,192(+) CTGTT(A/T)CCCGG utr-variant-3-prime
rs583346 -- 20,500,193(+) TGTTT(A/C)CCGGG utr-variant-3-prime

Relevant External Links for MUL1 Gene

HapMap Linkage Disequilibrium report
MUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUL1 Gene

Disorders for MUL1 Gene

Relevant External Links for MUL1

Genetic Association Database (GAD)
MUL1
Human Genome Epidemiology (HuGE) Navigator
MUL1

No disorders were found for MUL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MUL1 Gene

Publications for MUL1 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3 4
  2. Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. (PMID: 18207745) Neuspiel M. … McBride H.M. (Curr. Biol. 2008) 2 3 4
  3. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. (PMID: 18213395) Li W. … Joazeiro C.A.P. (PLoS ONE 2008) 2 3 4
  4. GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. (PMID: 18591963) Zhang B. … Shu H.-B. (Cell Res. 2008) 2 3 4
  5. MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. (PMID: 19407830) Braschi E. … McBride H.M. (EMBO Rep. 2009) 3 4

Products for MUL1 Gene

Sources for MUL1 Gene

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