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Aliases for MUCL1 Gene

Aliases for MUCL1 Gene

  • Mucin Like 1 2 3 5
  • Small Breast Epithelial Mucin 2 3 4
  • SBEM 3 4
  • Mucin-Like Protein 1 3
  • Protein BS106 4

External Ids for MUCL1 Gene

Previous GeneCards Identifiers for MUCL1 Gene

  • GC12P053539
  • GC12P055248
  • GC12P052287

Summaries for MUCL1 Gene

GeneCards Summary for MUCL1 Gene

MUCL1 (Mucin Like 1) is a Protein Coding gene. Diseases associated with MUCL1 include Breast Cancer and Colorectal Cancer 1. Among its related pathways are O-linked glycosylation and HIV Life Cycle.

UniProtKB/Swiss-Prot for MUCL1 Gene

  • May play a role as marker for the diagnosis of metastatic breast cancer.

Gene Wiki entry for MUCL1 Gene

Additional gene information for MUCL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUCL1 Gene

Genomics for MUCL1 Gene

Regulatory Elements for MUCL1 Gene

Enhancers for MUCL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H054932 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5 +104.9 104918 5 ATF1 NFIB NFRKB BATF RAD21 ZNF766 GATA2 ELK1 ZNF143 FOS TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 LOC105369778 GC12P054906
GH12H054734 0.6 ENCODE 7.7 -95.7 -95699 0 FOXA2 JUND HNF4G HNF4A REST ZBTB33 YY1 MUCL1 GC12M054691 ENSG00000257634
GH12H054854 0.7 ENCODE 5.6 +23.8 23755 0 CTCF ZNF654 RB1 TRIM22 REST RAD21 ZNF217 CC2D1A GATA3 ZNF143 MUCL1 GC12P054861
GH12H054847 0.5 Ensembl 5.5 +16.8 16844 0 CEBPA CEBPB CEBPG ZNF385A MUCL1 GC12P054861
GH12H054740 0.2 ENCODE 8.1 -88.9 -88875 2 TESPA1 MUCL1 GC12M054691 ENSG00000257634
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MUCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUCL1 Gene

Chromosome:
12
Start:
54,830,357 bp from pter
End:
54,858,393 bp from pter
Size:
28,037 bases
Orientation:
Plus strand

Genomic View for MUCL1 Gene

Genes around MUCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUCL1 Gene

Proteins for MUCL1 Gene

  • Protein details for MUCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR8-MUCL1_HUMAN
    Recommended name:
    Mucin-like protein 1
    Protein Accession:
    Q96DR8
    Secondary Accessions:
    • Q0VG95
    • Q32ZB5

    Protein attributes for MUCL1 Gene

    Size:
    90 amino acids
    Molecular mass:
    9039 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUCL1 Gene

Post-translational modifications for MUCL1 Gene

  • O-glycosylated.
  • Glycosylation at Thr23, posLast=2424, posLast=3030, posLast=3434, posLast=4646, Thr47, posLast=5151, posLast=5252, Thr54, Thr55, posLast=5959, Thr60, posLast=6262, Thr63, Ser66, posLast=6767, and posLast=6868

Other Protein References for MUCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUCL1 Gene

Domains & Families for MUCL1 Gene

Gene Families for MUCL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MUCL1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MUCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUCL1: view

No data available for UniProtKB/Swiss-Prot for MUCL1 Gene

Function for MUCL1 Gene

Molecular function for MUCL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as marker for the diagnosis of metastatic breast cancer.
genes like me logo Genes that share phenotypes with MUCL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MUCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUCL1 Gene

Localization for MUCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUCL1 Gene

Secreted. Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUCL1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MUCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MUCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUCL1 Gene

Pathways & Interactions for MUCL1 Gene

genes like me logo Genes that share pathways with MUCL1: view

Gene Ontology (GO) - Biological Process for MUCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with MUCL1: view

No data available for SIGNOR curated interactions for MUCL1 Gene

Drugs & Compounds for MUCL1 Gene

No Compound Related Data Available

Transcripts for MUCL1 Gene

Unigene Clusters for MUCL1 Gene

Mucin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MUCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MUCL1 Gene

No ASD Table

Relevant External Links for MUCL1 Gene

GeneLoc Exon Structure for
MUCL1
ECgene alternative splicing isoforms for
MUCL1

Expression for MUCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUCL1 Gene

mRNA differential expression in normal tissues according to GTEx for MUCL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.5), Skin - Not Sun Exposed (Suprapubic) (x18.6), and Breast - Mammary Tissue (x11.4).

Protein differential expression in normal tissues from HIPED for MUCL1 Gene

This gene is overexpressed in Urine (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUCL1 Gene



Protein tissue co-expression partners for MUCL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MUCL1 Gene:

MUCL1

SOURCE GeneReport for Unigene cluster for MUCL1 Gene:

Hs.348419

mRNA Expression by UniProt/SwissProt for MUCL1 Gene:

Q96DR8-MUCL1_HUMAN
Tissue specificity: Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.
genes like me logo Genes that share expression patterns with MUCL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUCL1 Gene

Orthologs for MUCL1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MUCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUCL1 33 34
  • 95.19 (n)
Species where no ortholog for MUCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUCL1 Gene

ENSEMBL:
Gene Tree for MUCL1 (if available)
TreeFam:
Gene Tree for MUCL1 (if available)

Paralogs for MUCL1 Gene

No data available for Paralogs for MUCL1 Gene

Variants for MUCL1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUCL1 Gene

MUCL1_HUMAN-Q96DR8
The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.

Sequence variations from dbSNP and Humsavar for MUCL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001711438 -- 54,853,249(+) AATTC(C/T)CTATG upstream-variant-2KB
rs1001862841 -- 54,857,784(+) CCCTA(A/C)GAAAT intron-variant
rs1001916534 -- 54,858,039(+) TGGTT(A/G)TTTAT intron-variant
rs1002026821 -- 54,853,065(+) CTTAG(A/C)ATGTT upstream-variant-2KB
rs1002145498 -- 54,858,544(+) CTAGT(C/T)TTGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MUCL1 Gene

Variant ID Type Subtype PubMed ID
nsv516882 CNV gain 19592680

Variation tolerance for MUCL1 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUCL1

Disorders for MUCL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MUCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
colorectal cancer 1
  • susceptibility to colorectal adenoma and cancer
pleural empyema
  • abscess of pleural cavity
- elite association - COSMIC cancer census association via MalaCards
Search MUCL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUCL1
genes like me logo Genes that share disorders with MUCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUCL1 Gene

Publications for MUCL1 Gene

  1. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. (PMID: 12019145) Miksicek RJ … Leygue E (Cancer research 2002) 2 3 4 22 60
  2. Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library. (PMID: 15880534) Wadle A … Renner C (International journal of cancer 2005) 3 4 22 60
  3. Human small breast epithelial mucin: the promise of a new breast tumor biomarker. (PMID: 15684711) Hubé F … Myal Y (DNA and cell biology 2004) 3 4 22 60
  4. Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data. (PMID: 15096563) Koga T … Yatabe Y (The Journal of molecular diagnostics : JMD 2004) 3 4 22 60
  5. Small breast epithelial mucin (SBEM) has the potential to be a marker for predicting hematogenous micrometastasis and response to neoadjuvant chemotherapy in breast cancer. (PMID: 20364301) Liu ZZ … Wang YK (Clinical & experimental metastasis 2010) 3 22 60

Products for MUCL1 Gene

Sources for MUCL1 Gene

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