MUCL1 Gene
protein-coding GIFtS: 43
GCID: GC12P055248
|
|
mucin-like 1
| |
Aliases
for MUCL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin-Like 11 2 | | SBEM1 2 3 5 | | Small Breast Epithelial Mucin2 3 | | Mucin-Like Protein 12 | | Protein BS1063 |
Export aliases for MUCL1 gene to outside databasesPrevious GC identifers: GC12P053539 GC12P052287 |
Summaries
for MUCL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MUCL1_HUMAN, Q96DR8Function: May play a role as marker for the diagnosis of metastatic breast cancer
Gene Wiki entry for MUCL1
|
Genomic Views
for MUCL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MUCL1 gene promoter:
FOXF2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 CBF-C E47 c-Rel CBF-B CBF-A Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUCL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUCL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2MUCL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P055248: view genomic region
(about GC identifiers)
Start:
|
55,224,303 bp from pter |
End:
|
55,252,177 bp from pter |
Size:
|
27,875 bases |
Orientation:
|
plus strand |
|
Proteins
for MUCL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUCL1_HUMAN, Q96DR8 (See
protein sequence)Recommended Name: Mucin-like protein 1 precursor Size: 90 amino acids; 9039 Da
Subcellular location: Secreted (Probable). Membrane (Probable)
Secondary accessions: Q0VG95 Q32ZB5Explore the universe of human proteins at neXtProt for MUCL1: NX_Q96DR8
Post-translational modifications:
O-glycosylated (Probable)1
View neXtProt modification sites for NX_Q96DR8
MUCL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_477521.1
ENSEMBL proteins: ENSP00000449369 ENSP00000311364 Reactome Protein details: Q96DR8
Human Recombinant Protein Products for MUCL1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MUCL1 for ontologies About GeneDecksing
MUCL1 Antibody Products:
Assay Products for MUCL1: |
Protein
Domains /
Families
for MUCL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96DR8 |
Function
for MUCL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MUCL1_HUMAN, Q96DR8Function: May play a role as marker for the diagnosis of metastatic breast cancerAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MUCL1 (NM_058173) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUCL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUCL1 |
|
Pathways & Interactions
for MUCL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for MUCL1 (see all 8)
MUCL1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MUCL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/44 Interacting proteins for MUCL1 (ENSP000003113644) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016266 | O-glycan processing |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
MUCL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUCL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MUCL1
Search CenterWatch for drugs/clinical trials and news about MUCL1
|
Transcripts
for MUCL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUCL1 gene: NM_058173.2 Unigene Cluster for MUCL1: Mucin-like 1 Hs.348419 [show with all ESTs]Unigene Representative Sequence: DA2456874 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000547990 ENST00000546809 ENST00000547958 ENST00000308796(uc001sgk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MUCL1 (NM_058173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUCL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUCL1 |
Additional cDNA sequence: AF414087.1 AY359062.1 BC111421.1 2 DOTS entries: DT.102655 DT.100741049 24/36 AceView cDNA sequences (see all 36): AW291950 NM_058173 AI905624 AW070916 W72838 AY359062 AA340069 AI905633 W72837 AF414087 BX487028 BG218084 AI905623 AW176044 BG202312 AI139456 BQ013778 BQ013284 BE092421 BQ012550 BG185269 BE186013 BE926938 BF742809
GeneLoc Exon Structure
|
Expression
for MUCL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUCL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCCTGTGA
About this image
See MUCL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUCL1
SOURCE GeneReport for Unigene cluster: Hs.348419
UniProtKB/Swiss-Prot: MUCL1_HUMAN, Q96DR8Tissue specificity: Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed incancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors.Detected in all lymph node containing metastatic cells
SABiosciences Custom PCR Arrays for MUCL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUCL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MUCL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUCL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUCL1 |
Orthologs
for MUCL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for MUCL1 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mucl15 |
mucin-like 1 |
-- |
|
15 103752063 |
ENSEMBL Gene Tree for MUCL1 (if available)
TreeFam Gene Tree for MUCL1 (if available) |
Paralogs
for MUCL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MUCL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: MUCL1_HUMAN, Q96DR8Polymorphism: The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancertumors
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MUCL1 (55224303 - 55252177 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MUCL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUCL1 |
|
Disorders
/ Diseases
for MUCL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUCL1 for disorders About GeneDecksing
OMIM gene information: 610857
OMIM disorders: --
5  diseases for MUCL1: About MalaCardspleural empyema breast cancer breast carcinoma carcinoma
prostatitis
7 Novoseek disease relationships for MUCL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
50.2 |
40 |
19221791 (7), 20364301 (6), 16004812 (5), 18269587 (3) (see all 7) |
| breast cancer metastatic |
45.6 |
1 |
12019145 (1) |
| carcinoma ductal |
44.5 |
2 |
12019145 (1), 15785316 (1) |
| primary tumor |
27.2 |
2 |
12019145 (1), 16004812 (1) |
| cancer |
22.4 |
6 |
18269587 (2), 18497056 (1), 18253069 (1), 20364301 (1) |
| metastasis |
20.3 |
5 |
12019145 (2), 20364301 (1) |
| tumors |
10.6 |
8 |
12019145 (2), 15684711 (1), 16720387 (1), 18497056 (1) (see all 6) |
Export disorders for MUCL1 gene to outside databases
|
Publications
for MUCL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUCL1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MUCL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel breast- and salivary gland-specific, mucin- like gene strongly expressed in normal and tumor human mammary epithelium. (PubMed id 12019145)1, 2, 3, 9 Miksicek R.J....Leygue E. (2002)
- Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data. (PubMed id 15096563)1, 2, 9 Koga T.... Yatabe Y. (2004)
- Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library. (PubMed id 15880534)1, 2, 9 Wadle A....Renner C. (2005)
- Human small breast epithelial mucin: the promise of a new breast tumor biomarker. (PubMed id 15684711)1, 2, 9 Hube F.... Myal Y. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- In silico and in vitro analysis of small breast epithelial mucin as a marker for bone marrow micrometastasis in breast cancer. (PubMed id 18497056)1, 9 Ayerbes M.V....Aparicio L.A. (2008)
- Small breast epithelial mucin (SBEM) has the potentia l to be a marker for predicting hematogenous micrometastasis and response to ne oadjuvant chemotherapy in breast cancer. (PubMed id 20364301)1, 9 Liu Z.Z....Wang Y.K. (2010)
- Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot stud y. (PubMed id 19221791)1, 9 Valladares-Ayerbes M....AntA^n-Aparicio L.M. (2009)
|
External Searches for MUCL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUCL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUCL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUCL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MUCL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MUCL1 gene:
Search GeneIP for patents involving MUCL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MUCL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MUCL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MUCL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUCL1 | | | OriGene Protein Over-expression Lysate for MUCL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MUCL1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MUCL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MUCL1 | | OriGene Custom Protein Services for MUCL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUCL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUCL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUCL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUCL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUCL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUCL1 |
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| | | | Search Tocris compounds for MUCL1 |
| |  |  |  |  | | | | |
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 | | | MUCL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MUCL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUCL1 |
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