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Aliases for MUC8 Gene

Aliases for MUC8 Gene

  • Mucin 8 2 3
  • Mucin 8, Tracheobronchial 2

External Ids for MUC8 Gene

Previous GeneCards Identifiers for MUC8 Gene

  • GC12U990060
  • GC12M132777
  • GC12M132674
  • GC12M131288
  • GC12M131659
  • GC12M131562
  • GC12M133049

Summaries for MUC8 Gene

GeneCards Summary for MUC8 Gene

MUC8 (Mucin 8) is a Protein Coding gene. Diseases associated with MUC8 include Chronic Ethmoiditis and Ethmoid Sinusitis.

Additional gene information for MUC8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC8 Gene

Genomics for MUC8 Gene

GeneHancer (GH) Regulatory Elements for MUC8 Gene

Promoters and enhancers for MUC8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I132473 Enhancer 1.2 FANTOM5 Ensembl ENCODE 550.8 -1.1 -1084 3.9 ZSCAN5A POLR2A VEZF1 TRIM24 RUNX3 RFX1 BHLHE40 GABPA MITF ZNF148 MUC8 FBRSL1 ENSG00000256875 GOLGA3 EP400P1 GC12P132472 GC12M132488
GH12I132467 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.6 +5.9 5882 3.3 SP1 ZBTB6 ZNF10 EBF1 KDM1A RUNX3 EGR2 ENSG00000256875 FBRSL1 MMP17 MUC8 GC12P132472
GH12I132470 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.8 +2.7 2705 2.6 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 SLC30A9 ZNF766 CBX5 E2F8 GC12P132472 ENSG00000256875 FBRSL1 MUC8
GH12I132481 Enhancer 0.9 FANTOM5 Ensembl ENCODE 0.4 -7.3 -7296 1.2 HLF CEBPA CEBPG MYC ENSG00000256875 LRCOL1 FBRSL1 CHFR ENSG00000250790 ANKLE2 MUC8 GC12M132488
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MUC8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MUC8 Gene

Genomic Locations for MUC8 Gene
chr12:132,471,100-132,474,630
(GRCh38/hg38)
Size:
3,531 bases
Orientation:
Minus strand
chr12:133,049,334-133,050,726
(GRCh37/hg19)

Genomic View for MUC8 Gene

Genes around MUC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC8 Gene

Proteins for MUC8 Gene

  • Protein details for MUC8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q12964
    Recommended name:
    Mucin
    Protein Accession:
    Q12964

    Protein attributes for MUC8 Gene

    Size:
    313 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC8 Gene

Post-translational modifications for MUC8 Gene

No Post-translational modifications

Other Protein References for MUC8 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MUC8 Gene

Domains & Families for MUC8 Gene

Gene Families for MUC8 Gene

HGNC:

Protein Domains for MUC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC8: view

No data available for UniProtKB/Swiss-Prot for MUC8 Gene

Function for MUC8 Gene

Phenotypes From GWAS Catalog for MUC8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC8 Gene

Localization for MUC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC8 gene
Compartment Confidence
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MUC8 Gene

Pathways & Interactions for MUC8 Gene

No Data Available

Interacting Proteins for MUC8 Gene

Gene Ontology (GO) - Biological Process for MUC8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MUC8 Gene

Drugs & Compounds for MUC8 Gene

No Compound Related Data Available

Transcripts for MUC8 Gene

mRNA/cDNA for MUC8 Gene

(2) REFSEQ mRNAs :

Alternative Splicing Database (ASD) splice patterns (SP) for MUC8 Gene

No ASD Table

Relevant External Links for MUC8 Gene

GeneLoc Exon Structure for
MUC8
ECgene alternative splicing isoforms for
MUC8

Expression for MUC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC8 Gene

mRNA differential expression in normal tissues according to GTEx for MUC8 Gene

This gene is overexpressed in Bladder (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MUC8 Gene:

MUC8

SOURCE GeneReport for Unigene cluster for MUC8 Gene:

Hs.592357
genes like me logo Genes that share expression patterns with MUC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC8 Gene

Orthologs for MUC8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MUC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745468 33
  • 91.63 (n)
Species where no ortholog for MUC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for MUC8 Gene

Paralogs for MUC8 Gene

No data available for Paralogs for MUC8 Gene

Variants for MUC8 Gene

Sequence variations from dbSNP and Humsavar for MUC8 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000145424 -- 132,476,087(-) A/G intron_variant
rs1000530780 -- 132,477,727(-) A/C upstream_transcript_variant
rs1000767742 -- 132,476,330(-) C/T intron_variant
rs1001409229 -- 132,471,547(-) C/T 3_prime_UTR_variant
rs1001493895 -- 132,475,974(-) G/A intron_variant

Variation tolerance for MUC8 Gene

Gene Damage Index Score: 24.28; 99.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC8 Gene

Disorders for MUC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MUC8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic ethmoiditis
  • chronic ethmoid sinusitis
ethmoid sinusitis
  • ethmoidal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search MUC8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MUC8

genes like me logo Genes that share disorders with MUC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC8 Gene

Publications for MUC8 Gene

  1. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. (PMID: 9070607) Shankar V … Sachdev GP (American journal of respiratory cell and molecular biology 1997) 2 3 58
  2. A novel human airway mucin cDNA encodes a protein with unique tandem-repeat organization. (PMID: 8002930) Shankar V … Sachdev GP (The Biochemical journal 1994) 2 3 58
  3. Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells. (PMID: 26782637) Song SY … Kim YD (International forum of allergy & rhinology 2016) 3 58
  4. Silencing of MUC8 by siRNA increases P2Y₂-induced airway inflammation. (PMID: 25575516) Cha HJ … Song KS (American journal of physiology. Lung cellular and molecular physiology 2015) 3 58
  5. Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-κB in human airway epithelial cells. (PMID: 24885580) Song SY … Kim YD (Journal of biomedical science 2014) 3 58

Products for MUC8 Gene

Sources for MUC8 Gene

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