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Aliases for MUC8 Gene

Aliases for MUC8 Gene

  • Mucin 8 2 3
  • Mucin 8, Tracheobronchial 2

External Ids for MUC8 Gene

Previous GeneCards Identifiers for MUC8 Gene

  • GC12U990060
  • GC12M132777
  • GC12M132674
  • GC12M131288
  • GC12M131659
  • GC12M131562
  • GC12M133049

Summaries for MUC8 Gene

GeneCards Summary for MUC8 Gene

MUC8 (Mucin 8) is a Protein Coding gene. Diseases associated with MUC8 include Chronic Ethmoiditis and Ethmoid Sinusitis.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC8 Gene

Genomics for MUC8 Gene

Regulatory Elements for MUC8 Gene

Enhancers for MUC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G132467 1.1 Ensembl ENCODE dbSUPER 5.6 +5.9 5883 3.3 SP1 CTCF MAZ ZNF10 KDM1A EBF1 EGR2 ENSG00000256875 FBRSL1 MMP17 MUC8 GC12P132472
GH12G132473 1.3 FANTOM5 Ensembl ENCODE 0.7 -1.1 -1085 3.9 ZSCAN5A RFX1 BHLHE40 NR3C1 GABPA RAD51 NR2C1 CREB1 ZBTB33 KDM1A FBRSL1 ENSG00000256875 GOLGA3 EP400NL MUC8 GC12M132488
GH12G132481 1.3 FANTOM5 Ensembl ENCODE 0.4 -7.3 -7297 1.2 CBX3 CEBPG NFXL1 ZBTB7B CBX5 ZNF143 TRIM24 RELB CREM EZH2 ENSG00000256875 LRCOL1 FBRSL1 CHFR ENSG00000250790 ANKLE2 GC12M132488 MUC8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MUC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for MUC8 Gene

132,471,100 bp from pter
132,474,630 bp from pter
3,531 bases
Minus strand

Genomic View for MUC8 Gene

Genes around MUC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC8 Gene

Proteins for MUC8 Gene

  • Protein details for MUC8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for MUC8 Gene

    313 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC8 Gene

Post-translational modifications for MUC8 Gene

No Post-translational modifications

Other Protein References for MUC8 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MUC8 Gene

Domains & Families for MUC8 Gene

Gene Families for MUC8 Gene


Protein Domains for MUC8 Gene


Suggested Antigen Peptide Sequences for MUC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC8: view

No data available for UniProtKB/Swiss-Prot for MUC8 Gene

Function for MUC8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC8 Gene

Localization for MUC8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC8 gene
Compartment Confidence
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MUC8 Gene

Pathways & Interactions for MUC8 Gene

No Data Available

Interacting Proteins for MUC8 Gene

Gene Ontology (GO) - Biological Process for MUC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for MUC8 Gene

Drugs & Compounds for MUC8 Gene

No Compound Related Data Available

Transcripts for MUC8 Gene

mRNA/cDNA for MUC8 Gene

(2) REFSEQ mRNAs :

Alternative Splicing Database (ASD) splice patterns (SP) for MUC8 Gene

No ASD Table

Relevant External Links for MUC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC8 Gene

mRNA differential expression in normal tissues according to GTEx for MUC8 Gene

This gene is overexpressed in Bladder (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MUC8 Gene:


SOURCE GeneReport for Unigene cluster for MUC8 Gene:

genes like me logo Genes that share expression patterns with MUC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC8 Gene

Orthologs for MUC8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MUC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC745468 34
  • 91.63 (n)
Species where no ortholog for MUC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for MUC8 Gene

Paralogs for MUC8 Gene

No data available for Paralogs for MUC8 Gene

Variants for MUC8 Gene

Sequence variations from dbSNP and Humsavar for MUC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000145424 -- 132,476,087(+) CAGCC(A/G)GTTAT intron-variant
rs1000530780 -- 132,477,727(+) TCGTG(A/C)TAGGT upstream-variant-2KB
rs1000767742 -- 132,476,330(+) TTCCT(C/T)CCTGA intron-variant
rs1001409229 -- 132,471,547(+) CACCA(C/T)GTCCA utr-variant-3-prime
rs1001493895 -- 132,475,974(+) TGGCC(A/G)GCAGT intron-variant

Variation tolerance for MUC8 Gene

Gene Damage Index Score: 24.28; 99.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC8 Gene

Disorders for MUC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MUC8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic ethmoiditis
  • chronic ethmoid sinusitis
ethmoid sinusitis
  • ethmoidal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search MUC8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC8 Gene

Publications for MUC8 Gene

  1. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. (PMID: 9070607) Shankar V. … Sachdev G.P. (Am. J. Respir. Cell Mol. Biol. 1997) 2 3 64
  2. A novel human airway mucin cDNA encodes a protein with unique tandem- repeat organization. (PMID: 8002930) Shankar V. … Sachdev G.P. (Biochem. J. 1994) 2 3 64
  3. Silencing of MUC8 by siRNA increases P2Ya88-induced airway inflammation. (PMID: 25575516) Cha H.J. … Song K.S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2015) 3 64
  4. Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-I_B in human airway epithelial cells. (PMID: 24885580) Song S.Y. … Kim Y.D. (J. Biomed. Sci. 2014) 3 64
  5. High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells. (PMID: 22521432) Kim D.E. … Kwon T.K. (Biochem. Biophys. Res. Commun. 2012) 3 64

Products for MUC8 Gene

Sources for MUC8 Gene

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