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Aliases for MUC8 Gene

Aliases for MUC8 Gene

  • Mucin 8 2 3
  • Mucin 8, Tracheobronchial 2

External Ids for MUC8 Gene

Previous GeneCards Identifiers for MUC8 Gene

  • GC12U990060
  • GC12M132777
  • GC12M132674
  • GC12M131288
  • GC12M131659
  • GC12M131562
  • GC12M133049

Summaries for MUC8 Gene

GeneCards Summary for MUC8 Gene

MUC8 (Mucin 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC8 Gene

Genomics for MUC8 Gene

Genomic Location for MUC8 Gene

Start:
132,472,748 bp from pter
End:
132,474,254 bp from pter
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for MUC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC8 Gene

No data available for Regulatory Elements for MUC8 Gene

Proteins for MUC8 Gene

  • Protein details for MUC8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q12964
    Recommended name:
    Mucin
    Protein Accession:
    Q12964
    Secondary Accessions:

    Protein attributes for MUC8 Gene

    Size:
    313 amino acids
    Molecular mass:
    33318 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUC8 Gene

Proteomics data for MUC8 Gene at MOPED

Post-translational modifications for MUC8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MUC8 Gene

Domains for MUC8 Gene

Gene Families for MUC8 Gene

HGNC:

Protein Domains for MUC8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MUC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC8: view

No data available for UniProtKB/Swiss-Prot for MUC8 Gene

Function for MUC8 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MUC8 Gene

Localization for MUC8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MUC8 Gene

Pathways for MUC8 Gene

SuperPathways for MUC8 Gene

No Data Available

Interacting Proteins for MUC8 Gene

Gene Ontology (GO) - Biological Process for MUC8 Gene

None

No data available for Pathways by source for MUC8 Gene

Transcripts for MUC8 Gene

mRNA/cDNA for MUC8 Gene

(2) REFSEQ mRNAs :

Alternative Splicing Database (ASD) splice patterns (SP) for MUC8 Gene

No ASD Table

Relevant External Links for MUC8 Gene

GeneLoc Exon Structure for
MUC8
ECgene alternative splicing isoforms for
MUC8

Expression for MUC8 Gene

mRNA expression in normal human tissues for MUC8 Gene

mRNA differential expression in normal tissues according to GTEx for MUC8 Gene

This gene is overexpressed in Bladder (4.0).

SOURCE GeneReport for Unigene cluster for MUC8 Gene Hs.592357

genes like me logo Genes that share expressions with MUC8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MUC8 Gene

Orthologs for MUC8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MUC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745468 35
  • 91.63 (n)
  • 84.24 (a)
Species with no ortholog for MUC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for MUC8 Gene

Paralogs for MUC8 Gene

No data available for Paralogs for MUC8 Gene

Variants for MUC8 Gene

Sequence variations from dbSNP and Humsavar for MUC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1574245 -- 132,472,507(-) TTCCT(C/T)GGGCA downstream-variant-500B
rs1955367 -- 132,475,863(-) GGGTG(C/T)GTGTG upstream-variant-2KB
rs1955368 -- 132,475,671(-) CGGGG(A/C)CTGCA upstream-variant-2KB
rs5003383 -- 132,476,125(-) TGACC(A/G)CCCGT upstream-variant-2KB
rs7309368 -- 132,476,176(+) CATCA(C/T)GGGCG upstream-variant-2KB

Relevant External Links for MUC8 Gene

HapMap Linkage Disequilibrium report
MUC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC8 Gene

Disorders for MUC8 Gene

No disorders were found for MUC8 Gene.

No data available for UniProtKB/Swiss-Prot for MUC8 Gene

Publications for MUC8 Gene

  1. A novel human airway mucin cDNA encodes a protein with unique tandem- repeat organization. (PMID: 8002930) Shankar V. … Sachdev G.P. (Biochem. J. 1994) 2 3
  2. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. (PMID: 9070607) Shankar V. … Sachdev G.P. (Am. J. Respir. Cell Mol. Biol. 1997) 2 3
  3. Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. (PMID: 12842905) Song K.S. … Yoon J.H. (J. Biol. Chem. 2003) 3
  4. MUC8 mucin gene up-regulation in chronic rhinosinusitis. (PMID: 15330148) Lee H.M. … Hwang S.J. (Ann. Otol. Rhinol. Laryngol. 2004) 3
  5. Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. (PMID: 15615708) Cho K.N. … Yoon J.H. (J. Biol. Chem. 2005) 3

Products for MUC8 Gene

Sources for MUC8 Gene

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