MUC7 Gene
protein-coding GIFtS: 55
GCID: GC04P071372
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|
mucin 7, secreted(Previous names: mucin 7, salivary )
| |
Aliases
for MUC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mucin 7, Secreted1 2 | | FLJ270471 | | MG21 2 3 | | Apo-MG23 | | Mucin 7, Salivary1 2 | | Mucin-71 | | Salivary Mucin-72 3 | | Apo-MG23 | | MUC-72 3 | | |
Export aliases for MUC7 gene to outside databasesPrevious GC identifers: GC04U990038 GC04P071587 GC04P071653 GC04P071518 GC04P067098 |
Summaries
for MUC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MUC7:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria inthe oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein containstandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats, and some alleles may beassociated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, butencoding the same protein, have been found for this gene.(provided by RefSeq, Feb 2009)
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding inmastication, speech, and swallowing. Binds P.aeruginosa pili
Gene Wiki entry for MUC7
|
Genomic Views
for MUC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MUC7
Other transcription factors
Search SABiosciences Chromatin IP Primers for MUC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3MUC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P071372: view genomic region
(about GC identifiers)
Start:
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71,296,209 bp from pter |
End:
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71,348,714 bp from pter |
Size:
|
52,506 bases |
Orientation:
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plus strand |
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Proteins
for MUC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7 (See
protein sequence)Recommended Name: Mucin-7 precursor Size: 377 amino acids; 39159 Da
Subunit: Monomer
Subcellular location: Secreted
Secondary accessions: Q9UCD7 Q9UCD8Explore the universe of human proteins at neXtProt for MUC7: NX_Q8TAX7
Post-translational modifications:
N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine1
View neXtProt modification sites for NX_Q8TAX7
MUC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138478.1 NP_001138479.1 NP_689504.2
ENSEMBL proteins: ENSP00000427594 ENSP00000302021 ENSP00000407422 ENSP00000400585 Reactome Protein details: Q8TAX7
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MUC7 for ontologies About GeneDecksing
MUC7 Antibody Products:
Assay Products for MUC7: |
Protein
Domains /
Families
for MUC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TAX7 |
Function
for MUC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding inmastication, speech, and swallowing. Binds P.aeruginosa pili Genatlas biochemistry entry for MUC7:mucin 7,salivary,expressed only in bladder cancer during the malignant transformation of bladder urothelium
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MUC7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MUC7:
|
Pathways & Interactions
for MUC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | | | 3 | Gastric acid secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for MUC7 (see all 8)
1 
Kegg Pathway (Kegg details for MUC7):
MUC7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/61 Interacting proteins for MUC7 (Q8TAX71, 3 ENSP000003020214) via UniProtKB, MINT, STRING, and/or I2D (see all 61)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AMY1B | P047451, 3 | EBI-738582,EBI-738586 I2D:
score=2 | | AMY1C | P047451, 3 | EBI-738582,EBI-738586 I2D:
score=2 | | HTN1 | P155151, 3, ENSP000002468964 | EBI-738582,EBI-738638 I2D:
score=1 STRING: ENSP00000246896 | | PRH1 | P028101, 3 | EBI-738582,EBI-738601 I2D:
score=1 | | PRH2 | P028101, 3 | EBI-738582,EBI-738601 I2D:
score=1 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016266 | O-glycan processing |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
MUC7 for ontologies About GeneDecksing
|
Drugs & Compounds
for MUC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MUC7 for compounds About GeneDecksing
 Browse Tocris compounds for MUC7
8 Novoseek chemical compound relationships for MUC7 gene About this table
Search CenterWatch for drugs/clinical trials and news about MUC7
|
Transcripts
for MUC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MUC7 gene (3 alternative transcripts): NM_001145006.1 NM_001145007.1 NM_152291.2 Unigene Cluster for MUC7: Mucin 7, secreted Hs.631946 [show with all ESTs]Unigene Representative Sequence: NM_0011450067 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515308 ENST00000505411 ENST00000504482 ENST00000304887(uc003hfj.3)
ENST00000514512 ENST00000413702(uc011cat.2) ENST00000456088(uc011cau.2)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MUC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MUC7 (NM_001145007) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MUC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MUC7 |
Additional cDNA sequence: AK093828.1 AK312855.1 BC025688.1 BX537739.1 BX647190.1 BX648903.1 BX648904.1 L13283.1 21 DOTS entries: DT.101987506 DT.92014457 DT.40120482 DT.101987511 DT.121249392 DT.100735123 DT.121249485 DT.121249312 DT.101966218 DT.121249359 DT.121249414 DT.121249429 DT.121249516 DT.121249295 DT.121249389 DT.121249473 DT.121249293 DT.121249301 DT.121249430 DT.121249532 DT.121249562 24/160 AceView cDNA sequences (see all 160): BP333703 BP333743 BC025688 BX486968 BP334505 BP334938 BP333948 BP335008 BP335114 BP335118 AI203550 BP334874 BP334625 BP333997 BP334119 BX486980 NM_152291 BP335067 BP335107 BX487368 BX487563 BX486966 BX487203 BX487313
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MUC7 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MUC7
|
Expression
for MUC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MUC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAATGTAT
About this image
See MUC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC7
SOURCE GeneReport for Unigene cluster: Hs.631946
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7Tissue specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g.sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotidgland)
SABiosciences Custom PCR Arrays for MUC7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MUC7
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC7 |
Orthologs
for MUC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MUC7 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for MUC7 (if available)
TreeFam Gene Tree for MUC7 (if available) |
Paralogs
for MUC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MUC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7Polymorphism: The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) eachcomposed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individualsfrom a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in allpopulations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in EastAsians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protectiverole in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern Europeanindividual
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MUC7
1 CNV: 2529
Human Gene Mutation Database (HGMD): MUC7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC7 |
|
Disorders
/ Diseases
for MUC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MUC7 for disorders About GeneDecksing
OMIM gene information: 158375
OMIM disorders: 600807
UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7
Genetic variations in MUC7 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most commonchronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype,largely attributed to the interactions among many genes and between these genes and the environment. It ischaracterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi
20/30  diseases for MUC7 (see all 30): About MalaCardsasthma, protection against asthma otitis media ethmoid sinusitis
dental caries diffuse panbronchiolitis severe combined immunodeficiency panbronchiolitis
combined immunodeficiency oral candidiasis candidiasis mucoepidermoid carcinoma
gastroduodenitis pyelonephritis bronchiolitis sinusitis
cystic fibrosis bladder carcinoma immunodeficiency fibrosis
1 disease from the University of Copenhagen DISEASES database for MUC7:Ethmoid sinusitis 6 Novoseek disease relationships for MUC7 gene About this table
Genetic Association Database (GAD): MUC7
Human Genome Epidemiology (HuGE) Navigator: MUC7 (11 documents)
Export disorders for MUC7 gene to outside databases
|
Publications
for MUC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MUC7 gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with MUC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic polymorphism of MUC7: allele frequencies and association with asthma. (PubMed id 11378823)1, 2, 4 Kirkbride H.J.... Swallow D.M. (2001)
- Structure and chromosomal localization of the human salivary mucin gene, MUC7. (PubMed id 8838308)1, 3, 9 Bobek L.A....Levine M.J. (1996)
- Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). (PubMed id 7690757)1, 2, 9 Bobek L.A.... Levine M.J. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo. (PubMed id 16514118)1, 9 Li S....Bobek L.A. (2006)
- Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells. (PubMed id 16778149)1, 9 Li S. and Bobek L.A. (2006)
- MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. (PubMed id 16759176)1, 9 Rousseau K....Swallow D.M. (2006)
- Molecular characterization of a major high molecular weight mucin from human sublingual gland. (PubMed id 9363439)1, 9 Troxler R.F....Offner G.D. (1997)
- A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PubMed id 21529783)1 Heath A.C....Montgomery G.W. (2011)
- Mucin expression pattern in pancreatic diseases: find ings from EUS-guided fine-needle aspiration biopsies. (PubMed id 21647207)1 Carrara S....Testoni P.A. (2011)
|
External Searches for MUC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MUC7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MUC7 | Pharmacogenomics, SNPs, Pathways | | Mucin database | http://www.medkem.gu.se/mucinbiology/databases/ |
|
| | |
About This Section
| Patent Information for MUC7 gene:
Search GeneIP for patents involving MUC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MUC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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