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Aliases for MUC7 Gene

Aliases for MUC7 Gene

  • Mucin 7, Secreted 2 3
  • Mucin 7, Salivary 2 3
  • Salivary Mucin-7 3 4
  • Apo-MG2 3 4
  • MUC-7 3 4
  • MG2 3 4
  • Mucin-7 3

External Ids for MUC7 Gene

Previous GeneCards Identifiers for MUC7 Gene

  • GC04U990038
  • GC04P071587
  • GC04P071653
  • GC04P071518
  • GC04P071372
  • GC04P067098

Summaries for MUC7 Gene

Entrez Gene Summary for MUC7 Gene

  • This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

UniProtKB/Swiss-Prot for MUC7 Gene

  • May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

Gene Wiki entry for MUC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC7 Gene

Genomics for MUC7 Gene

Genomic Location for MUC7 Gene

Start:
70,430,492 bp from pter
End:
70,482,997 bp from pter
Size:
52,506 bases
Orientation:
Plus strand

Genomic View for MUC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC7 Gene

No data available for Regulatory Elements for MUC7 Gene

Proteins for MUC7 Gene

  • Protein details for MUC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAX7-MUC7_HUMAN
    Recommended name:
    Mucin-7
    Protein Accession:
    Q8TAX7
    Secondary Accessions:
    • Q9UCD7
    • Q9UCD8

    Protein attributes for MUC7 Gene

    Size:
    377 amino acids
    Molecular mass:
    39159 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MUC7 Gene

Proteomics data for MUC7 Gene at MOPED

Post-translational modifications for MUC7 Gene

  • N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.
  • Glycosylation at Asn97, Asn128, Asn135, and Asn146

Other Protein References for MUC7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC7 Gene

Domains for MUC7 Gene

Gene Families for MUC7 Gene

HGNC:

Protein Domains for MUC7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MUC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC7: view

No data available for UniProtKB/Swiss-Prot for MUC7 Gene

Function for MUC7 Gene

Molecular function for MUC7 Gene

GENATLAS Biochemistry: mucin 7,salivary,expressed only in bladder cancer during the malignant transformation of bladder urothelium
UniProtKB/Swiss-Prot Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

Gene Ontology (GO) - Molecular Function for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
genes like me logo Genes that share ontologies with MUC7: view

Phenotypes for MUC7 Gene

GenomeRNAi human phenotypes for MUC7:
genes like me logo Genes that share phenotypes with MUC7: view

Animal Model Products

CRISPR Products

miRNA for MUC7 Gene

miRTarBase miRNAs that target MUC7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MUC7 Gene

Localization for MUC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC7 Gene COMPARTMENTS Subcellular localization image for MUC7 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytosol 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MUC7: view

Pathways for MUC7 Gene

genes like me logo Genes that share pathways with MUC7: view

Pathways by source for MUC7 Gene

Gene Ontology (GO) - Biological Process for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC7: view

Compounds for MUC7 Gene

(8) Novoseek inferred chemical compound relationships for MUC7 Gene

Compound -log(P) Hits PubMed IDs
anti-fungal 31.7 3
sulfamethoxazole 31.2 1
retinoic acid 14.7 1
proline 9.23 3
leucine 4.3 3
genes like me logo Genes that share compounds with MUC7: view

Transcripts for MUC7 Gene

Unigene Clusters for MUC7 Gene

Mucin 7, secreted:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for MUC7 Gene

GeneLoc Exon Structure for
MUC7
ECgene alternative splicing isoforms for
MUC7

Expression for MUC7 Gene

mRNA expression in normal human tissues for MUC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC7 Gene

This gene is overexpressed in Minor Salivary Gland (52.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC7 Gene

SOURCE GeneReport for Unigene cluster for MUC7 Gene Hs.631946

mRNA Expression by UniProt/SwissProt for MUC7 Gene

Q8TAX7-MUC7_HUMAN
Tissue specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
genes like me logo Genes that share expressions with MUC7: view

In Situ Assay Products

Orthologs for MUC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC7 35
  • 99.06 (n)
  • 98.31 (a)
MUC7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC7 35
  • 66.84 (n)
  • 51.3 (a)
dog
(Canis familiaris)
Mammalia LOC102153116 35
  • 63.46 (n)
  • 46.52 (a)
MUC7 36
  • 44 (a)
OneToOne
Species with no ortholog for MUC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC7 Gene

ENSEMBL:
Gene Tree for MUC7 (if available)
TreeFam:
Gene Tree for MUC7 (if available)

Paralogs for MUC7 Gene

No data available for Paralogs for MUC7 Gene

Variants for MUC7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC7 Gene

Q8TAX7-MUC7_HUMAN
The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual

Sequence variations from dbSNP and Humsavar for MUC7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs523208 -- 70,434,408(+) tattg(G/T)tctat intron-variant
rs881730 -- 70,463,704(+) TTGGC(A/G)TATAC intron-variant
rs881731 -- 70,463,772(+) cctcc(C/T)gctat intron-variant
rs962922 -- 70,443,516(+) ACCCA(C/T)ATCAA intron-variant
rs986229 -- 70,472,532(-) ACTTA(A/T)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MUC7 Gene

Variant ID Type Subtype PubMed ID
nsv829964 CNV Gain 17160897
dgv1642e1 CNV Complex 17122850
nsv518183 CNV Loss 19592680
esv2727789 CNV Deletion 23290073
esv2727790 CNV Deletion 23290073

Relevant External Links for MUC7 Gene

HapMap Linkage Disequilibrium report
MUC7
Human Gene Mutation Database (HGMD)
MUC7

Disorders for MUC7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MUC7 Gene including...

Search for MUC7 Gene in MalaCards »

(1) OMIM Diseases for MUC7 Gene (158375)

UniProtKB/Swiss-Prot

MUC7_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:11378823}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MUC7 Gene

(6) Novoseek inferred disease relationships for MUC7 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 41 5
bladder tumors 38 2
metastasis 8.18 1
carcinoma 4.01 2
tumors 0 6

Relevant External Links for MUC7

Genetic Association Database (GAD)
MUC7
Human Genome Epidemiology (HuGE) Navigator
MUC7
genes like me logo Genes that share disorders with MUC7: view

Publications for MUC7 Gene

  1. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). (PMID: 7690757) Bobek L.A. … Levine M.J. (J. Biol. Chem. 1993) 3 4 23
  2. Structure and chromosomal localization of the human salivary mucin gene, MUC7. (PMID: 8838308) Bobek L.A. … Levine M.J. (Genomics 1996) 2 3 23
  3. Genetic polymorphism of MUC7: allele frequencies and association with asthma. (PMID: 11378823) Kirkbride H.J. … Swallow D.M. (Eur. J. Hum. Genet. 2001) 3 4 48
  4. MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. (PMID: 16759176) Rousseau K. … Swallow D.M. (Ann. Hum. Genet. 2006) 3 23 48
  5. Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo. (PMID: 16514118) Li S. … Bobek L.A. (Am. J. Respir. Cell Mol. Biol. 2006) 3 23

Products for MUC7 Gene

Sources for MUC7 Gene

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