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MUC7 Gene

protein-coding   GIFtS: 60
GCID: GC04P071372

Mucin 7, Secreted

(Previous names: mucin 7, salivary)
  See MUC7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mucin 7, Secreted1 2     MUC-72 3
Mucin 7, Salivary1 2     apo-MG22
Salivary Mucin-72 3     mucin-72
MG22 3     Apo-MG23

External Ids:    HGNC: 75181   Entrez Gene: 45892   Ensembl: ENSG000001711957   OMIM: 1583755   UniProtKB: Q8TAX73   
ORGUL members:         

Export aliases for MUC7 gene to outside databases

Previous GC identifers: GC04U990038 GC04P071587 GC04P071653 GC04P071518 GC04P067098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MUC7 Gene:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of
bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this
glycoprotein contains tandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats,
and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with
different 5' UTR, but encoding the same protein, have been found for this gene.(provided by RefSeq, Feb 2009)

GeneCards Summary for MUC7 Gene:
MUC7 (mucin 7, secreted) is a protein-coding gene. Diseases associated with MUC7 include asthma, protection against, and ethmoid sinusitis.

UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7
Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and
aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili

Gene Wiki entry for MUC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MUC7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC7 promoter sequence
   Search Chromatin IP Primers for MUC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

MUC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071372:  view genomic region     (about GC identifiers)

Start:
71,296,209 bp from pter      End:
71,348,714 bp from pter
Size:
52,506 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7 (See protein sequence)
Recommended Name: Mucin-7 precursor  
Size: 377 amino acids; 39159 Da
Subunit: Monomer
Secondary accessions: Q9UCD7 Q9UCD8

Explore the universe of human proteins at neXtProt for MUC7: NX_Q8TAX7

Explore proteomics data for MUC7 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine1
  • Glycosylation2 at Asn97, Asn128, Asn135, Asn146

  • See MUC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138478.1  NP_001138479.1  NP_689504.2  

    ENSEMBL proteins: 
     ENSP00000427594   ENSP00000302021   ENSP00000407422   ENSP00000400585  
    Reactome Protein details: Q8TAX7

    MUC7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    ProtoNet protein and cluster: Q8TAX7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC7_HUMAN, Q8TAX7
    Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and
    aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili

         Genatlas biochemistry entry for MUC7:
    mucin 7,salivary,expressed only in bladder cancer during the malignant transformation of bladder urothelium

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16203048
         
    Find genes that share ontologies with MUC7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MUC7:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MUC7

    miRNA
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    miRTarBase miRNAs that target MUC7:
    hsa-mir-26b-5p (MIRT029062)

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    2 qRT-PCR Assays for microRNAs that regulate MUC7:
    hsa-miR-522 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidMUC7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC7_HUMAN, Q8TAX7: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    cytosol1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005796Golgi lumen TAS--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with MUC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MUC7 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Salivary secretion
    Salivary secretion0.34


    Find genes that share SuperPaths with MUC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for MUC7
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis


    1 Kegg Pathway  (Kegg details for MUC7):
        Salivary secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC7
    Interactions:

        GeneGlobe Interaction Network for MUC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MUC7 (Q8TAX71, 3 ENSP000003020214) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1BP047451, 3EBI-738582,EBI-738586 I2D: score=2 
    AMY1CP047451, 3EBI-738582,EBI-738586 I2D: score=2 
    HTN1P155151, 3, ENSP000002468964EBI-738582,EBI-738638 I2D: score=1 STRING: ENSP00000246896
    PRH1P028101, 3EBI-738582,EBI-738601 I2D: score=1 
    PRH2P028101, 3EBI-738582,EBI-738601 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with MUC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC7

    8 Novoseek inferred chemical compound relationships for MUC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anti-fungal 31.7 3 10817697 (1), 14659657 (1), 12543672 (1)
    sulfamethoxazole 31.2 1 16650064 (1)
    retinoic acid 14.7 1 11246122 (1)
    proline 9.23 4 9881747 (3)
    leucine 4.3 3 11021659 (2), 11241221 (1)
    cysteine 3.77 2 10642514 (1)
    threonine 3.09 1 10532235 (1)
    serine 0 1 10532235 (1)



    Find genes that share compounds with MUC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MUC7 gene (3 alternative transcripts): 
    NM_001145006.1  NM_001145007.1  NM_152291.2  

    Unigene Cluster for MUC7:

    Mucin 7, secreted
    Hs.631946  [show with all ESTs]
    Unigene Representative Sequence: NM_001145006
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515308 ENST00000505411 ENST00000504482 ENST00000304887(uc003hfj.3)
    ENST00000514512 ENST00000413702(uc011cat.2) ENST00000456088(uc011cau.2)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MUC7:
    hsa-miR-522 hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidMUC7 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MUC7
      QuantiTect SYBR Green Assays in human, mouse, rat MUC7
      QuantiFast Probe-based Assays in human, mouse, rat MUC7

    Additional mRNA sequence: 

    AK093828.1 AK312855.1 BC025688.1 BX537739.1 BX647190.1 BX648903.1 BX648904.1 L13283.1 

    21 DOTS entries:

    DT.101987506  DT.92014457  DT.40120482  DT.101987511  DT.121249392  DT.100735123  DT.121249485  DT.121249312 
    DT.101966218  DT.121249359  DT.121249414  DT.121249429  DT.121249516  DT.121249295  DT.121249389  DT.121249473 
    DT.121249293  DT.121249301  DT.121249430  DT.121249532  DT.121249562 

    Selected AceView cDNA sequences (see all 160):

    BP333703 BP334119 BX486966 BP334938 BP333743 BC025688 BX486968 BP335118 
    BX487313 BP334505 BX487368 BX486980 BP333997 NM_152291 BP335067 BP334874 
    BP334625 BP335114 BP335107 AI203550 BP333948 BX487203 BP335008 BX487563 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MUC7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -                                             
    SP2:                                                            
    SP3:                                                            
    SP4:                                -     -                     
    SP5:                          -                                 


    ECgene alternative splicing isoforms for MUC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MUC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATGTAT
    MUC7 Expression
    About this image


    MUC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebellum
    MUC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631946

    UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7
    Tissue specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g.
    sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid
    gland)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for MUC7 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1021531161 mucin-7-like 63.46(n)
    46.52(a)
      102153116  XM_005642281.1  XP_005642338.1 


    ENSEMBL Gene Tree for MUC7 (if available)
    TreeFam Gene Tree for MUC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MUC7_HUMAN, Q8TAX7: The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here)
    each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375
    individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most
    common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans
    to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems
    to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1
    Northern European individual


    Selected SNPs for MUC7 (see all 1301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21720031,2
    C,F,A,H--67104563(+) tcactC/Ttattt 1 -- int13Minor allele frequency- T:0.33NA 6
    rs100500671,2
    C,H--67104565(+) actttT/Atttca 1 -- int12Minor allele frequency- A:0.25NA 4
    rs779266941,2
    C--67146959(+) TCCTC-/AGAGAT 3 -- int10--------
    rs1840123781,2
    --71169316(+) GACAAC/TGTAGG 1 -- us2k10--------
    rs1891505191,2
    C--71169317(+) ACAACA/GTAGGC 1 -- us2k10--------
    rs728527821,2
    C,F--71169399(+) AAAAAT/CTGATG 1 -- us2k13Minor allele frequency- C:0.10WA CSA 122
    rs1164767541,2
    F--71169401(+) AAATTG/TATGAA 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs68579101,2
    C--71169543(+) tttacA/Gagaaa 1 -- us2k10--------
    rs1850978301,2
    --71169610(+) ATGACA/GTACAT 1 -- us2k10--------
    rs1907447201,2
    --71169620(+) TGCAGC/GCAACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MUC7 (71296209 - 71348714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MUC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727789CNV Deletion23290073
    esv2727790CNV Deletion23290073
    nsv518183CNV Loss19592680
    nsv829964CNV Gain17160897
    dgv1642e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MUC7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC7
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 158375   
    OMIM disorders: 600807  
    UniProtKB/Swiss-Prot: MUC7_HUMAN, Q8TAX7
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is
    a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many
    genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal
    dyspnea, with wheezing due to spasmodic contraction of the bronchi. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • 6 diseases for MUC7:    
    About MalaCards
    asthma, protection against    ethmoid sinusitis    hfe-associated hereditary hemochromatosis    diffuse panbronchiolitis
    oral candidiasis    asthma

    1 disease from the University of Copenhagen DISEASES database for MUC7:
    Ethmoid sinusitis

    Find genes that share disorders with MUC7           About GenesLikeMe

    6 Novoseek inferred disease relationships for MUC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 41 5 15036676 (3), 9865718 (1), 12478110 (1)
    bladder tumors 38 2 9865718 (1), 12478110 (1)
    metastasis 8.18 1 15036676 (1)
    carcinoma 4.01 2 12478110 (1), 16426915 (1)
    tumors 0 9 15036676 (2), 15897748 (1), 16770570 (1), 18696039 (1) (see all 5)
    cancer 0 4 9829729 (2), 15897748 (1)

    Genetic Association Database (GAD): MUC7
    Human Genome Epidemiology (HuGE) Navigator: MUC7 (11 documents)

    Export disorders for MUC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC7 gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with MUC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of MUC7: allele frequencies and association with asthma. (PubMed id 11378823)1, 2, 4 Kirkbride H.J.... Swallow D.M. (Eur. J. Hum. Genet. 2001)
    2. Structure and chromosomal localization of the human salivary mucin gene, MUC7. (PubMed id 8838308)1, 3, 9 Bobek L.A....Levine M.J. (Genomics 1996)
    3. MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. (PubMed id 16759176)1, 4, 9 Rousseau K....Swallow D.M. (Ann. Hum. Genet. 2006)
    4. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). (PubMed id 7690757)1, 2, 9 Bobek L.A.... Levine M.J. (J. Biol. Chem. 1993)
    5. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PubMed id 21529783)1, 4 Heath A.C....Montgomery G.W. (Biol. Psychiatry 2011)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. MUC7 polymorphisms are associated with a decreased risk of a diagnosis of asthma in an African American population. (PubMed id 19820409)1, 4 Watson A.M....Rose M.C. (J. Investig. Med. 2009)
    10. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4589 HGNC: 7518 AceView: MUC7 Ensembl:ENSG00000171195 euGenes: HUgn4589
    ECgene: MUC7 Kegg: 4589 H-InvDB: MUC7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MUC7 Pharmacogenomics, SNPs, Pathways
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MUC7 gene:
    Search GeneIP for patents involving MUC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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