Aliases for MUC6 Gene
Aliases for MUC6 Gene
External Ids for MUC6 Gene
- HGNC: 7517
- Entrez Gene: 4588
- Ensembl: ENSG00000184956
- OMIM: 158374
- UniProtKB: Q6W4X9
Previous GeneCards Identifiers for MUC6 Gene
- GC11U990090
- GC11P000176
- GC11M001008
- GC11M000974
- GC11M000828
Summaries for MUC6 Gene
-
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]
GeneCards Summary for MUC6 Gene
MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC6 include Pancreatic Ductal Carcinoma and Signet Ring Cell Adenocarcinoma. Among its related pathways are Immune System and HIV Life Cycle. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5AC.
UniProtKB/Swiss-Prot for MUC6 Gene
-
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC6 Gene
Genomics for MUC6 Gene
Regulatory Elements for MUC6 Gene
Enhancers for MUC6 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11F001039 | 0.9 | FANTOM5 ENCODE | 35.8 | -3.4 | -3386 | 1.6 | MAZ CEBPB MAX GLI4 MNT POLR2A MYNN KDM1A TCF7L2 | MUC6 AP2A2 CD151 LOC101927503 GC11P001047 |
| GH11F001043 | 0.6 | FANTOM5 | 44.6 | -7.0 | -7041 | 0.2 | RAD51 L3MBTL2 MAX MNT MYC MGA | MUC6 AP2A2 GC11P001047 LOC101927503 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MUC6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MUC6 gene promoter:
Regulatory Element Products
Genomic Location for MUC6 Gene
- Chromosome:
- 11
- Start:
- 1,012,821 bp from pter
- End:
- 1,036,706 bp from pter
- Size:
- 23,886 bases
- Orientation:
- Minus strand
Genomic View for MUC6 Gene
Genes around MUC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC
MUC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MUC6 Gene
Proteins for MUC6 Gene
-
Protein details for MUC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6W4X9-MUC6_HUMAN
- Recommended name:
- Mucin-6
- Protein Accession:
- Q6W4X9
- O15329
- Q14394
- Q2TUQ5
- Q4L207
- Q8N8I1
- Q8NAK1
Protein attributes for MUC6 Gene
- Size:
- 2439 amino acids
- Molecular mass:
- 257051 Da
- Quaternary structure:
-
- Multimer; disulfide-linked.
- SequenceCaution:
-
- Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for MUC6 Gene
Post-translational modifications for MUC6 Gene
- O-glycosylated.
- Glycosylation at Asn 268, Asn 486, Asn 659, Asn 975, Asn 1179, and Asn 2366
- Modification sites at PhosphoSitePlus
Other Protein References for MUC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top MUC6 Antibody
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-
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-
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- antibodies-online Antibodies for MUC6: See all 38
- GeneTex MUC6 antibody for MUC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for MUC6
Protein Products
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-
Cloud-Clone Corp. Proteins for MUC6
- antibodies-online Proteins for MUC6: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MUC6
No data available for DME Specific Peptides for MUC6 Gene
Domains & Families for MUC6 Gene
Gene Families for MUC6 Gene
- HGNC:
Protein Domains for MUC6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MUC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6W4X9- Domain:
-
- Contains 1 CTCK (C-terminal cystine knot-like) domain.
- Contains 1 TIL (trypsin inhibitory-like) domain.
- Contains 3 VWFD domains.
Function for MUC6 Gene
Molecular function for MUC6 Gene
- GENATLAS Biochemistry:
- mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia
- UniProtKB/Swiss-Prot Function:
- May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | NAS | 7680650 |
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MUC6 gene
-
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- Search ViGene Biosciences for MUC6
CRISPR Products
-
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miRNA for MUC6 Gene
- miRTarBase miRNAs that target MUC6
miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
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-
ViGene Biosciences adenoviral particle packaged cDNA for MUC6 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC6 Gene
Localization for MUC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MUC6 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 4 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for MUC6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Defective GALNT12 causes colorectal cancer 1 (CRCS1) |
.62
|
|
| 2 | Diseases of glycosylation | ||
| 3 | Immune System |
.61
|
|
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for MUC6 Gene
Interacting Proteins for MUC6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0030277 | maintenance of gastrointestinal epithelium | IEA,NAS | 7680650 |
No data available for SIGNOR curated interactions for MUC6 Gene
Transcripts for MUC6 Gene
mRNA/cDNA for MUC6 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (83) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MUC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MUC6
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miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for MUC6 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MUC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MUC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | - |
Expression for MUC6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for MUC6 Gene
This gene is overexpressed in Stomach (x32.7), Pancreas (x12.9), and Cervix - Endocervix (x4.1).
This gene is overexpressed in Pancreatic juice (56.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC6 Gene
NURSA nuclear receptor signaling pathways regulating expression of MUC6 Gene:
MUC6SOURCE GeneReport for Unigene cluster for MUC6 Gene:
Hs.528432mRNA Expression by UniProt/SwissProt for MUC6 Gene:
Q6W4X9-MUC6_HUMAN
Tissue specificity:
Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunners glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Primer Products
-
OriGene qPCR primer pairs for MUC6
No data available for Protein tissue co-expression partners for MUC6 Gene
Orthologs for MUC6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MUC6 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC100856444 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Muc6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Muc6 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MUC6 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MUC6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MUC6 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MUC6 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for MUC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MUC6 Gene
Variants for MUC6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MUC6 Gene
- MUC6_HUMAN-Q6W4X9
- The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs148581741 | Uncertain significance | 1,018,419(+) | TGACT(A/G)TGTGA | reference, missense | |
| rs113508205 | untested | 1,016,890(+) | AGGTG(A/G)GGAGT | reference, missense | |
| rs587777897 | untested | 1,018,224(-) | GCTAC(A/T)TTCAC | reference, missense | |
| rs10736904 | -- | 1,018,069(+) | AGGTG(A/G)GGAGT | reference, missense | |
| rs10751676 | -- | 1,018,012(+) | GGTCT(G/T)GAAGG | reference, missense |
Residual Variation Intolerance Score:
100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.49;
97.17% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MUC6 Gene
Disorders for MUC6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic ductal carcinoma |
|
|
| signet ring cell adenocarcinoma |
|
|
| small intestine cancer |
|
|
| cystadenoma |
|
|
| ovarian mucinous neoplasm |
|
|
Search MUC6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MUC6
No data available for UniProtKB/Swiss-Prot and Genatlas for MUC6 Gene
Publications for MUC6 Gene
- Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PMID: 15979574) Sakai H. … Yuasa Y. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
- The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PMID: 15081123) Rousseau K. … Toribara N.W. (Genomics 2004) 3 4 22 64
- Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PMID: 15280409) Xia H.H.-X. … Wong B.C.-Y. (J. Clin. Pathol. 2004) 3 4 22 64
- Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PMID: 11988092) Nordman H. … Carlstedt I. (Biochem. J. 2002) 3 4 22 64
- The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PMID: 9195947) Toribara N.W. … Kim Y.S. (J. Biol. Chem. 1997) 3 4 22 64
Products for MUC6 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MUC6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MUC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
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- (98) BioGPS
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- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (115) ProteomicsDB
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