MUC6 Gene

Aliases
for MUC6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11U990090 GC11P000176 GC11M001008 GC11M000974 GC11M000828

Summaries
for MUC6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MUC6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NT_187656.1  NT_187681.1  NC_000011.9  NC_018922.2  NT_009237.19  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC6

MUC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001002:  view genomic region     (about GC identifiers)

Proteins
for MUC6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MUC6: NX_Q6W4X9

Explore proteomics data for MUC6 at MOPED

Post-translational modifications: 

MUC6 Human Recombinant Protein Products:

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MUC6 Assay Products:

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Domains /
Families
for MUC6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q6W4X9

Find genes that share domains with MUC6           About GenesLikeMe

Function
for MUC6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for MUC6

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

Localization
for MUC6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
golgi apparatus	4
plasma membrane	2
cytoskeleton	1
cytosol	1
lysosome	1
mitochondrion	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for MUC6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for MUC6 About     See pathways by source

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	SuperPath	Contained pathways About
1	O-linked glycosylation of mucins	O-linked glycosylation of mucins 0.47 Termination of O-glycan biosynthesis 0.38
2	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Post-translational protein modification 0.43 Metabolism of proteins 0.30

2 Reactome Pathways for MUC6

	O-linked glycosylation of mucins
	Termination of O-glycan biosynthesis

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for MUC6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MUC6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MUC6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MUC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGAACGTGA

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NULL (Uncategorized)
Endoderm progenitor-like cells
Stomach (Gastrointestinal Tract)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

Orthologs
for MUC6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MUC6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MUC6 gene

MUC5AC²  ZAN²  TECTA²  MUC2²  OTOG²  OTOGL²  MUC19²  FCGBP²  

VWF²  BMPER²  

Find genes that share paralogs with MUC6           About GenesLikeMe

Genomic Variants
for MUC6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MUC6 (see all 1219)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1135599341,2	C,F	untested1	1016910(+)	AGGGTG/ATGGGT	2	/T /I	mis1		3		NA CSA	6
rs788199241,2	C	untested1	1017789(+)	GCGTCA/CTTGTT	2	R M	mis1		0	--	--	--	--
rs1485817411,2	C	untested1	1018419(+)	TGACTA/GTGTGA	2	T I	mis1		0	--	--	--	--
rs1410511671,2	C	--	1012837(+)	AAGAAC/GCGGTT	1	--	ut31		0	--	--	--	--
rs1448645291,2		--	1012867(+)	GGTGAC/TGCCCT	1	--	ut31		0	--	--	--	--
rs799417511,2	F	--	1012970(+)	ACCCTC/TTGCCC	1	--	ut31		1		EA	120
rs2004499141,2	C	--	1012985(-)	CCCCAA/GAGTCA	1	--	ut31		0	--	--	--	--
rs1476082431,2	C	--	1012993(+)	GGGAT-/CTCCTCTT	1	--	cds1		0	--	--	--	--
rs1871105731,2		--	1012996(+)	ATCTCC/TTCTTC	1	--	ut31		0	--	--	--	--
rs1920769841,2		--	1013064(+)	CTCCTC/TGCCCC	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for MUC6 (1012821 - 1036706 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MUC6 (see all 33):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2743883	CNV	Deletion	23290073
esv2743878	CNV	Deletion	23290073
esv2743884	CNV	Deletion	23290073
esv2669189	CNV	Deletion	23128226
nsv820593	CNV	Duplication	20802225
esv1474704	CNV	Insertion	17803354
nsv59	CNV	Insertion	15895083
nsv7637	CNV	Insertion	18451855
esv988598	CNV	Insertion	20482838
nsv469923	CNV	Loss	18288195

Human Gene Mutation Database (HGMD): MUC6

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MUC6

DNA2.0 Custom Variant and Variant Library Synthesis for MUC6

Disorders / Diseases
for MUC6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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7 diseases for MUC6

Selected Novoseek inferred disease relationships for MUC6 gene (see all 38)    About this table

Publications
for MUC6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Human gastric mucin. Identification of a unique species by expression cloning. (PubMed id 7680650)^{1, 2, 3} Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1993)
2. Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PubMed id 15280409)^{1, 2, 9} Xia H.H.-X.... Wong B.C.-Y. (J. Clin. Pathol. 2004)
3. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PubMed id 11988092)^{1, 2, 9} Nordman H....Carlstedt I. (Biochem. J. 2002)
4. Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PubMed id 15979574)^{1, 2, 9} Sakai H.... Yuasa Y. (Biochem. Biophys. Res. Commun. 2005)
5. The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)^{1, 2, 9} Rousseau K....Toribara N.W. (Genomics 2004)
6. The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PubMed id 9195947)^{1, 2, 9} Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1997)
7. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. (PubMed id 9422745)^{1, 2, 9} Debailleul V.... Porchet N. (J. Biol. Chem. 1998)
8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
10. Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma by regulating gene. (PubMed id 20506113)^{1, 4} Kwon J.A....Leem S.H. (Hum. Mutat. 2010)

External Searches for MUC6 gene

Genome Databases showing MUC6 gene

Other Databases showing MUC6 gene

Specialized Databases showing MUC6 gene

Products
for MUC6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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