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MUC6 Gene

protein-coding   GIFtS: 57
GCID: GC11M001002

Mucin 6, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 6, gastric)
  See MUC6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucin 6, Oligomeric Mucus/Gel-Forming1 2
Mucin 6, Gastric1 2
Gastric Mucin-62 3
MUC-62 3
mucin-62

External Ids:    HGNC: 75171   Entrez Gene: 45882   Ensembl: ENSG000001849567   OMIM: 1583745   UniProtKB: Q6W4X93   

Export aliases for MUC6 gene to outside databases

Previous GC identifers: GC11U990090 GC11P000176 GC11M001008 GC11M000974 GC11M000828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MUC6 Gene:
The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial
cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal
tract (summary by Toribara et al., 1993 (PubMed 7680650)).(supplied by OMIM, Dec 2010)

GeneCards Summary for MUC6 Gene:
MUC6 (mucin 6, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC6 include pancreatic ductal carcinoma, and epstein-barr virus-associated gastric carcinoma. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9
Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid
secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the
cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in
epithelial organogenesis

Gene Wiki entry for MUC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187656.1  NT_187681.1  NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MUC6 gene promoter:
         p53   Sp1   Olf-1   Tal-1beta   LCR-F1   NF-kappaB1   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MUC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001002:  view genomic region     (about GC identifiers)

Start:
1,012,821 bp from pter      End:
1,036,706 bp from pter
Size:
23,886 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9 (See protein sequence)
Recommended Name: Mucin-6 precursor  
Size: 2439 amino acids; 257051 Da
Subunit: Multimer; disulfide-linked
Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic
ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic
zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13
weeks and at lower levels from 17 to 23 weeks of gestation
Sequence caution: Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu;
Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O15329 Q14394 Q2TUQ5 Q4L207 Q8N8I1 Q8NAK1

Explore the universe of human proteins at neXtProt for MUC6: NX_Q6W4X9

Explore proteomics data for MUC6 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Asn268, Asn486, Asn659, Asn975, Asn1179, Asn2366

  • See MUC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005952.2  
    ENSEMBL proteins: 
     ENSP00000406861   ENSP00000433246   ENSP00000436903   ENSP00000433790  
    Reactome Protein details: Q6W4X9

    MUC6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    4 InterPro protein domains:
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR002919 TIL_dom
     IPR001846 VWF_type-D

    Graphical View of Domain Structure for InterPro Entry Q6W4X9

    ProtoNet protein and cluster: Q6W4X9

    1 Blocks protein domain: IPB002919 Trypsin inhibitor-like

    UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
    Similarity: Contains 3 VWFD domains


    Find genes that share domains with MUC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC6_HUMAN, Q6W4X9
    Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid
    secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the
    cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in
    epithelial organogenesis
    Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription
    factors

         Genatlas biochemistry entry for MUC6:
    mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS7680650
         
    Find genes that share ontologies with MUC6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MUC6

    miRNA
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    miRTarBase miRNAs that target MUC6:
    hsa-mir-335-5p (MIRT018331)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC6_HUMAN, Q6W4X9: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    plasma membrane2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--

    Find genes that share ontologies with MUC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MUC6 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with MUC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MUC6
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC6
    Interactions:

        Search GeneGlobe Interaction Network for MUC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MUC6 (Q6W4X93 ENSP000004068614) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFF1P041553, ENSP000002915274I2D: score=1 STRING: ENSP00000291527
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GALNT1ENSP000002691954STRING: ENSP00000269195
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0030277maintenance of gastrointestinal epithelium NAS7680650
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC6

    8 Novoseek inferred chemical compound relationships for MUC6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 5.55 1 11253133 (1)
    calcium 3.04 2 12517055 (2)
    cholesterol 0 3 12517055 (2), 14634353 (1)
    oligonucleotide 0 1 11673830 (1)
    progesterone 0 2 15086841 (1), 15737028 (1)
    estrogen 0 4 15737028 (2), 15086841 (1), 9650551 (1)
    polysaccharide 0 1 14632674 (1)
    5fluorouracil 0 1 14576935 (1)



    Find genes that share compounds with MUC6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MUC6 gene: 
    NM_005961.2  

    Unigene Cluster for MUC6:

    Mucin 6, oligomeric mucus/gel-forming
    Hs.528432  [show with all ESTs]
    Unigene Representative Sequence: NM_005961
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421673(uc001lsw.2) ENST00000532016 ENST00000527242 ENST00000525923

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK092533.1 AK096772.1 AK098503.1 AY312160.1 AY458429.1 U97698.1 

    9 DOTS entries:

    DT.97847590  DT.120730951  DT.95288353  DT.91682232  DT.120730948  DT.91750804  DT.95341118  DT.75101750 
    DT.87002890 

    Selected AceView cDNA sequences (see all 83):

    AA588236 BM856696 BM769894 BM768868 BM769293 BM773490 AI420483 BQ082919 
    BM798703 AI732669 BM773506 AA687898 BM773508 BM767214 BM856626 BM768831 
    BQ084019 AI868225 BM823251 AW130323 BM818289 BM794541 BM823218 BM790820 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MUC6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                    -               
    SP2:              -                     


    ECgene alternative splicing isoforms for MUC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MUC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAACGTGA
    MUC6 Expression
    About this image


    MUC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Stomach (Gastrointestinal Tract)
    MUC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528432

    UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9
    Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura
    mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected
    gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic
    centroacinar cells and ducts, and periductal glands of the common bile duct

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MUC6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc61 , 5 mucin 6, gastric1, 5 75.09(n)1
    70.97(a)1
      7 (87.03 cM)5
    3533281  NM_181729.21  NP_859418.11 
     1416340495 
    chicken
    (Gallus gallus)
    Aves MUC66
    mucin 6, oligomeric mucus/gel-forming
    38(a)
    1 ↔ 1
    5(14423044-14459159) ENSGALG00000020492
    lizard
    (Anolis carolinensis)
    Reptilia MUC66
    mucin 6, oligomeric mucus/gel-forming
    56(a)
    1 ↔ 1
    1(72416633-72464090)


    ENSEMBL Gene Tree for MUC6 (if available)
    TreeFam Gene Tree for MUC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MUC6 gene
    MUC5AC2  ZAN2  TECTA2  MUC22  OTOG2  OTOGL2  MUC192  FCGBP2  
    VWF2  BMPER2  

    Find genes that share paralogs with MUC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    MUC6_HUMAN, Q6W4X9: The number of repeats is highly polymorphic and varies among different alleles. These repeats are
    very similar but not identical


    Selected SNPs for MUC6 (see all 1219)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135599341,2
    C,Funtested11016910(+) AGGGTG/ATGGGT 2 /T /I mis13Minor allele frequency- A:0.50NA CSA 6
    rs788199241,2
    Cuntested11017789(+) GCGTCA/CTTGTT 2 R M mis10--------
    rs1485817411,2
    Cuntested11018419(+) TGACTA/GTGTGA 2 T I mis10--------
    rs1410511671,2
    C--1012837(+) AAGAAC/GCGGTT 1 -- ut310--------
    rs1448645291,2
    --1012867(+) GGTGAC/TGCCCT 1 -- ut310--------
    rs799417511,2
    F--1012970(+) ACCCTC/TTGCCC 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs2004499141,2
    C--1012985(-) CCCCAA/GAGTCA 1 -- ut310--------
    rs1476082431,2
    C--1012993(+) GGGAT-/CTCCTCTT 1 -- cds10--------
    rs1871105731,2
    --1012996(+) ATCTCC/TTCTTC 1 -- ut310--------
    rs1920769841,2
    --1013064(+) CTCCTC/TGCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MUC6 (1012821 - 1036706 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MUC6 (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743883CNV Deletion23290073
    esv2743878CNV Deletion23290073
    esv2743884CNV Deletion23290073
    esv2669189CNV Deletion23128226
    nsv820593CNV Duplication20802225
    esv1474704CNV Insertion17803354
    nsv59CNV Insertion15895083
    nsv7637CNV Insertion18451855
    esv988598CNV Insertion20482838
    nsv469923CNV Loss18288195

    Human Gene Mutation Database (HGMD): MUC6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 158374    OMIM disorders: --

    6 diseases for MUC6:    
    About MalaCards
    pancreatic ductal carcinoma    epstein-barr virus-associated gastric carcinoma    biliary papillomatosis    pseudomyxoma peritonei
    h. pylori infection    duodenal ulcer

    5 diseases from the University of Copenhagen DISEASES database for MUC6:
    Carcinoma     Adenoma     Biliary papillomatosis     Pseudomyxoma peritonei
    Gastritis

    Find genes that share disorders with MUC6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MUC6 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric carcinoma 73.9 37 15737028 (4), 11745219 (3), 15354218 (2), 12719460 (2) (see all 21)
    metaplasia 72.7 27 10070955 (4), 14508397 (3), 16545139 (2), 11093805 (1) (see all 10)
    carcinoma mucinous 72.5 7 12493022 (4), 15976813 (1), 18493590 (1)
    adenocarcinoma 61.2 29 15753982 (5), 19094709 (2), 14623937 (2), 15086835 (2) (see all 16)
    carcinoma 57.3 17 15260848 (3), 11253133 (2), 15071739 (2), 16135257 (2) (see all 11)
    adenoma 56.5 23 19855374 (6), 9935202 (3), 17085661 (2), 15260848 (2) (see all 8)
    carcinoma bronchioloalveolar 52.2 5 11274635 (2), 15151204 (2)
    dysplasia 50.2 16 9935202 (3), 18097286 (2), 16949933 (2), 15260848 (2) (see all 7)
    carcinoma pancreatic ductal 50 1 16018800 (1)
    gastric polyp 48.2 2 10398119 (1), 10699992 (1)

    Genetic Association Database (GAD): MUC6
    Human Genome Epidemiology (HuGE) Navigator: MUC6 (9 documents)

    Export disorders for MUC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC6 gene, integrated from 10 sources (see all 213):
    (articles sorted by number of sources associating them with MUC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gastric mucin. Identification of a unique species by expression cloning. (PubMed id 7680650)1, 2, 3 Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1993)
    2. Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PubMed id 15280409)1, 2, 9 Xia H.H.-X.... Wong B.C.-Y. (J. Clin. Pathol. 2004)
    3. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PubMed id 11988092)1, 2, 9 Nordman H....Carlstedt I. (Biochem. J. 2002)
    4. Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PubMed id 15979574)1, 2, 9 Sakai H.... Yuasa Y. (Biochem. Biophys. Res. Commun. 2005)
    5. The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)1, 2, 9 Rousseau K....Toribara N.W. (Genomics 2004)
    6. The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PubMed id 9195947)1, 2, 9 Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1997)
    7. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. (PubMed id 9422745)1, 2, 9 Debailleul V.... Porchet N. (J. Biol. Chem. 1998)
    8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    10. Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma by regulating gene. (PubMed id 20506113)1, 4 Kwon J.A....Leem S.H. (Hum. Mutat. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4588 HGNC: 7517 AceView: MUC6 Ensembl:ENSG00000184956 euGenes: HUgn4588
    ECgene: MUC6 H-InvDB: MUC6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MUC6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC6 Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MUC6 gene:
    Search GeneIP for patents involving MUC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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