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MUC6 Gene(Protein Coding)

Mucin 6, Oligomeric Mucus/Gel-Forming

GCID:
GC11M001002
GIFtS:
55
Genes Participants
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Aliases for MUC6 Gene

Aliases for MUC6 Gene

  • Mucin 6, Oligomeric Mucus/Gel-Forming 2 3 5
  • Gastric Mucin-6 3 4
  • MUC-6 3 4
  • Mucin 6, Gastric 2

External Ids for MUC6 Gene

Previous GeneCards Identifiers for MUC6 Gene

  • GC11U990090
  • GC11P000176
  • GC11M001008
  • GC11M000974
  • GC11M000828

Summaries for MUC6 Gene

Entrez Gene Summary for MUC6 Gene

  • The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010]

GeneCards Summary for MUC6 Gene

MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC6 include Stomach Cancer and Pancreatic Ductal Carcinoma. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1). GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OTOG.

UniProtKB/Swiss-Prot for MUC6 Gene

  • May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

Gene Wiki entry for MUC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC6 Gene

Genomics for MUC6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MUC6 Gene

Enhancers for MUC6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MUC6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MUC6 gene promoter:

Genomic Location for MUC6 Gene

Chromosome:
11
Start:
1,012,821 bp from pter
End:
1,036,706 bp from pter
Size:
23,886 bases
Orientation:
Minus strand

Genomic View for MUC6 Gene

Genes around MUC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MUC6 Gene

Proteins for MUC6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MUC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6W4X9-MUC6_HUMAN
    Recommended name:
    Mucin-6
    Protein Accession:
    Q6W4X9
    Secondary Accessions:
    • O15329
    • Q14394
    • Q2TUQ5
    • Q4L207
    • Q8N8I1
    • Q8NAK1

    Protein attributes for MUC6 Gene

    Size:
    2439 amino acids
    Molecular mass:
    257051 Da
    Quaternary structure:
    • Multimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MUC6 Gene

Proteomics data for MUC6 Gene at MOPED

Protein Expression for MUC6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MUC6 Gene

  • O-glycosylated.
  • Glycosylation at Asn 268, Asn 486, Asn 659, Asn 975, Asn 1179, and Asn 2366
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC6 Gene

Domains & Families for MUC6 Gene

Gene Families for MUC6 Gene

HGNC:

Protein Domains for MUC6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6W4X9

UniProtKB/Swiss-Prot:

MUC6_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 TIL (trypsin inhibitory-like) domain.
  • Contains 3 VWFD domains.
genes like me logo Genes that share domains with MUC6: view

Function for MUC6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MUC6 Gene

GENATLAS Biochemistry:
mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia
UniProtKB/Swiss-Prot Function:
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.

Animal Model Products

miRNA for MUC6 Gene

miRTarBase miRNAs that target MUC6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC6 Gene

Localization for MUC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC6 Gene COMPARTMENTS Subcellular localization image for MUC6 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MUC6 Gene

Pathways & Interactions for MUC6 Gene

genes like me logo Genes that share pathways with MUC6: view

Gene Ontology (GO) - Biological Process for MUC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030277 maintenance of gastrointestinal epithelium IEA,NAS 7680650
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MUC6: view

No data available for SIGNOR curated interactions for MUC6 Gene

Drugs & Compounds for MUC6 Gene

Products:

  1. Drug

(4) Drugs for MUC6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MUC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC6: view

Transcripts for MUC6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MUC6 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC6 Gene

Mucin 6, oligomeric mucus/gel-forming:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -

Relevant External Links for MUC6 Gene

GeneLoc Exon Structure for
MUC6
ECgene alternative splicing isoforms for
MUC6

Expression for MUC6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MUC6 Gene

mRNA expression in normal human tissues for MUC6 Gene
mRNA expression by BioGPS for MUC6 GenemRNA expression by GTEx for MUC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC6 Gene

This gene is overexpressed in Stomach (x32.7), Pancreas (x12.9), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for MUC6 Gene

This gene is overexpressed in Pancreatic juice (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC6 Gene



SOURCE GeneReport for Unigene cluster for MUC6 Gene Hs.528432

mRNA Expression by UniProt/SwissProt for MUC6 Gene

Q6W4X9-MUC6_HUMAN
Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunners glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
genes like me logo Genes that share expression patterns with MUC6: view

Primer Products

No data available for Protein tissue co-expression partners for MUC6 Gene

Orthologs for MUC6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia LOC100856444 35
  • 80.87 (n)
  • 76.62 (a)
-- 36
  • 57 (a)
 OneToMany
-- 36
  • 77 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Muc6 35
  • 75.09 (n)
  • 70.97 (a)
Muc6 16
Muc6 36
  • 50 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia MUC6 35
  • 94.65 (n)
  • 92.96 (a)
rat
(Rattus norvegicus)
 Mammalia Muc6 35
  • 68.8 (n)
  • 62.29 (a)
oppossum
(Monodelphis domestica)
 Mammalia MUC6 36
  • 65 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MUC6 36
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MUC6 36
  • 38 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MUC6 36
  • 56 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 31 (a)
 OneToOne
Species with no ortholog for MUC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC6 Gene

ENSEMBL:
Gene Tree for MUC6 (if available)
TreeFam:
Gene Tree for MUC6 (if available)

Paralogs for MUC6 Gene

Paralogs for MUC6 Gene

genes like me logo Genes that share paralogs with MUC6: view

Variants for MUC6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC6 Gene

MUC6_HUMAN-Q6W4X9
The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Sequence variations from dbSNP and Humsavar for MUC6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_059542 -
rs35549382 - 1,017,421(+) TGTGG(G/T)TAGCC reference, missense
rs11602095 -- 1,022,117(+) gcccc(A/G)cgccc intron-variant
rs11602663 -- 1,020,778(+) GCCTC(C/T)CCACC intron-variant
rs11604757 -- 1,029,320(+) GTGTC(C/T)GGGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MUC6 Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
essv11734 CNV CNV 17122850
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
dgv332e1 CNV Complex 17122850
nsv428244 CNV Loss 18775914
essv22587 CNV CNV 17122850
nsv896640 CNV Loss 21882294
dgv957n71 CNV Loss 21882294
nsv896643 CNV Loss 21882294
nsv896644 CNV Loss 21882294
nsv832045 CNV Gain+Loss 17160897
dgv958n71 CNV Loss 21882294
nsv7637 CNV Insertion 18451855
nsv482155 CNV Gain 20164927
esv988598 CNV Insertion 20482838
nsv511474 CNV Loss 21212237
nsv59 CNV Insertion 15895083
esv23591 CNV Loss 19812545
nsv825684 CNV Gain 20364138
nsv820593 CNV Duplication 20802225
dgv187n67 CNV Gain 20364138
dgv10n47 CNV Gain 21111241
esv2743883 CNV Deletion 23290073
esv3523 CNV Complex 18987735
nsv825688 CNV Gain 20364138
esv2743884 CNV Deletion 23290073
esv7984 CNV Loss 19470904
esv3671 CNV Complex 18987735
esv1474704 CNV Insertion 17803354
nsv896648 CNV Loss 21882294
dgv959n71 CNV Loss 21882294

Variation tolerance for MUC6 Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.49; 97.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC6 Gene

Human Gene Mutation Database (HGMD)
MUC6

Disorders for MUC6 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MUC6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
stomach cancer
  • ca body - stomach
pancreatic ductal carcinoma
  • malignant neoplasm of duct of wirsung
small intestine cancer
  • small intestine neoplasm
microcystic adenoma
  • adenoma microcystic
cystadenoma
  • cystoma
- elite association - COSMIC cancer census association via MalaCards
Search MUC6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC6

Genetic Association Database (GAD)
MUC6
Human Genome Epidemiology (HuGE) Navigator
MUC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC6
genes like me logo Genes that share disorders with MUC6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC6 Gene

Publications for MUC6 Gene

  1. Human gastric mucin. Identification of a unique species by expression cloning. (PMID: 7680650) Toribara N.W. … Kim Y.S. (J. Biol. Chem. 1993) 2 3 4 67
  2. Expression of gastric pyloric mucin, MUC6, in colorectal serrated polyps. (PMID: 19855374) Bartley A.N. … Hamilton S.R. (Mod. Pathol. 2010) 3 23
  3. Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus. (PMID: 17401217) Burjonrappa S.C. … Loggie B. (Indian J Cancer 2007) 3 23
  4. Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. (PMID: 17471237) Vincent A. … Van Seuningen I. (Oncogene 2007) 3 23
  5. Evaluation of MUC6 mucin tandem repeats. (PMID: 15716126) Parry S. … Harris A. (Biochim. Biophys. Acta 2005) 3 23

Products for MUC6 Gene

Sources for MUC6 Gene

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