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Aliases & Descriptions for MUC6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Gastric mucin-6 3 | | mucin 6, gastric 1, 2 | | mucin 6, oligomeric mucus/gel-forming 2 |
|
| | Search outside databases for aliases for MUC6 genePrevious GC identifers: GC11U990090 GC11P000176 GC11M001008 GC11M000974 |
Summaries for MUC6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesisGene Wiki entry for MUC6 |
Genomic Location for MUC6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MUC6 gene 
Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5MUC6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M001002:
(about GC identifiers)
Start:
|
1,002,824 bp from pter |
End:
|
1,026,706 bp from pter |
Size:
|
23,883 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_035113.6
| Proteins for MUC6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9 (See
protein sequence)Recommended Name: Mucin-6 precursor Size: 2392 amino acids; 252165 Da
Subunit: Multimer; disulfide-linked
Subcellular location: Secreted
Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation
Sequence caution: Sequence=AK092533; Type=Erroneous termination; Positions=2310; Note=Translated as Glu;
Secondary accessions: O15329 Q14394 Q2TUQ5 Q4L207 Q8N8I1 Q8NAK1Post-translational modifications:
O-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005952.2
ENSEMBL proteins: ENSP00000371696
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- | About this table
Antibodies for MUC6: Assays for MUC6: | Protein
Domains/ Families for MUC6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6W4X9
ProtoNet protein and cluster: Q6W4X9 1 Blocks protein family: IPB002919 Trypsin inhibitor-like
UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity: Contains 1 TIL (trypsin inhibitory-like) domainSimilarity: Contains 3 VWFD domains | Gene Function for MUC6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Applied Biosystems Silencer® siRNAs for MUC6
Sigma-Aldrich siRNA for MUC6  Sigma-Aldrich shRNA for MUC6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005961                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005961                                  untagged cDNA clone in CMV expression vector: NM_005961 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005961
UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesisInduction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factorsGenatlas biochemistry entry for MUC6:mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005201 | extracellular matrix structural constituent |
NAS | 7680650 | About this table | Pathways & Interactions for MUC6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/14 Interacting proteins for MUC6 (ENSP000003716963) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030277 | maintenance of gastrointestinal epithelium |
NAS | 7680650 | About this table
|
Drugs & Compounds for MUC6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MUC6 4 Novoseek chemical compound relationships for MUC6 gene
About this table
|
Transcripts for MUC6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                  Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for MUC6  Sigma-Aldrich shRNA for MUC6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005961 REFSEQ mRNAs for MUC6 gene: NM_005961.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005961               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005961                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005961                                  untagged cDNA clone in CMV expression vector: NM_005961  Additional cDNA sequence: AK092533.1 AK096772.1 AK098503.1 AY312160.1 AY458429.1 U97698.1 9 DOTS entries: DT.97847590 DT.120730951 DT.95288353 DT.91682232 DT.120730948 DT.91750804 DT.95341118 DT.75101750 DT.87002890 24/83 AceView cDNA sequences (see all 83
):BM769293 AI732669 BM856696 BM768868 BM798703 BM823251 AA588236 BM818289 BM767214 AA687898 BM769894 BQ084019 BQ082919 AW130323 AI420483 BM794541 BM773508 BM856626 BM773490 BM768831 AI868225 BM773506 BM831149 BQ082729
highest scoring ESTs for MUC6:AY312160 U97698 AA588236 AA603459 AI420483 AI468227 AI521662 AI732669 AI804760 AI868225 Unigene Cluster for MUC6: Mucin 6, oligomeric mucus/gel-forming Hs.528432 [show with all ESTs]Unigene Representative Sequence: NM_005961
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MUC6
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for MUC6
1 Ensembl transcript including schematic representation: ENST00000382261
|
Expression for MUC6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MUC6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MUC6
1 / 2 / 3 5 probe-sets matching MUC6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCGAACGTGA
SOURCE GeneReport for Unigene cluster: Hs.528432 UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct |
Orthologs for MUC6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MUC6 gene from 4 species
About this table Species with no ortholog for MUC6
ENSEMBL Gene Tree for MUC6 | Paralogs for MUC6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for MUC6 gene
- MUC22 VWF2
|
SNPs/Variants for MUC6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9Polymorphism: The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical
HapMap Linkage Disequilibrium images for MUC6 (up to first 250kb)
|
Disorders & Mutations for MUC6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 158374
10/37 Novoseek disease relationships for MUC6 gene (see all 37
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gastric carcinoma |
74.78 |
37 |
15737028 (4), 11745219 (3), 15354218 (2), 12719460 (2) (see all 21) |
| metaplasia |
73.60 |
27 |
10070955 (4), 14508397 (3), 16545139 (2), 11093805 (1) (see all 10) |
| carcinoma mucinous |
72.16 |
7 |
12493022 (4), 15976813 (1), 18493590 (1) |
| adenocarcinoma |
60.66 |
26 |
15753982 (5), 19094709 (2), 14623937 (2), 15086835 (2) (see all 15) |
| carcinoma |
57.37 |
17 |
15260848 (3), 11253133 (2), 15071739 (2), 16135257 (2) (see all 11) |
| adenoma |
55.34 |
15 |
9935202 (3), 17085661 (2), 15260848 (2), 12820724 (2) (see all 7) |
| carcinoma bronchioloalveolar |
53.72 |
5 |
11274635 (2), 15151204 (2) |
| dysplasia |
51.53 |
16 |
9935202 (3), 18097286 (2), 16949933 (2), 15260848 (2) (see all 7) |
| carcinoma pancreatic ductal |
50.97 |
1 |
16018800 (1) |
| gastric polyp |
49.61 |
2 |
10398119 (1), 10699992 (1) |
About this table
Human Genome Epidemiology Navigator: MUC6 (2 documents)
|
Medical News for MUC6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MUC6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/189 PubMed articles for MUC6 gene (see all 189
):- Human gastric mucin. Identification of a unique species by expression cloning. (PubMed id 7680650)2, 3, 4 Toribara N.W.... Kim Y.S. (1993)
- Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PubMed id 15280409)1, 3, 4 Xia H.H.-X.... Wong B.C.-Y. (2004)
- Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PubMed id 11988092)1, 3, 4 Nordman H....Carlstedt I. (2002)
- Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PubMed id 15979574)1, 3, 4 Sakai H.... Yuasa Y. (2005)
- The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)1, 3, 4 Rousseau K....Toribara N.W. (2004)
- The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PubMed id 9195947)1, 3, 4 Toribara N.W.... Kim Y.S. (1997)
- Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. (PubMed id 9422745)1, 3, 4 Debailleul V.... Porchet N. (1998)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)3, 4 Taylor T.D....Sakaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts. (PubMed id 10330458)3, 4 Reid C.J. and Harris A. (1999)
|
Search for MUC6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MUC6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MUC6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Mucin database | http://www.medkem.gu.se/mucinbiology/databases/ |
|
| | | About This Section
| --
| Services for MUC6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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