Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MUC6 Gene

protein-coding GIFtS: 58
GCID: GC11M001002

Mucin 6, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 6, gastric)

Microbiology & Infectious Diseases Congress

43 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mucin 6, Oligomeric Mucus/Gel-Forming¹ ²
Mucin 6, Gastric¹ ²
Gastric Mucin-6² ³
MUC-6² ³
mucin-6²

External Ids:	HGNC: 7517¹	Entrez Gene: 4588²	Ensembl: ENSG00000184956⁷	OMIM: 158374⁵	UniProtKB: Q6W4X9³

ORGUL members:
	NONCODE¹⁴:n340933

Export aliases for MUC6 gene to outside databases

Previous GC identifers: GC11U990090 GC11P000176 GC11M001008 GC11M000974 GC11M000828

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MUC6 Gene:

The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection

from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by

Toribara et al., 1993 (PubMed 7680650)).(supplied by OMIM, Dec 2010)

GeneCards Summary for MUC6 Gene:

MUC6 (mucin 6, oligomeric mucus/gel-forming) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MUC6 include gastroduodenitis, and epstein-barr virus-associated gastric carcinoma, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid

secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection

of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial

organogenesis

Gene Wiki entry for MUC6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MUC6 gene promoter:
p53 Sp1 Olf-1 Tal-1beta LCR-F1 NF-kappaB1 E47
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MUC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

MUC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC6 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M001002: view genomic region (about GC identifiers)

Start:	1,012,821 bp from pter	End:	1,036,706 bp from pter
Size:	23,886 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9 (See protein sequence)

Recommended Name: Mucin-6 precursor

Size: 2439 amino acids; 257051 Da

Subunit: Multimer; disulfide-linked

Subcellular location: Secreted

Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at

18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the

kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower

levels from 17 to 23 weeks of gestation

Sequence caution: Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu;

Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: O15329 Q14394 Q2TUQ5 Q4L207 Q8N8I1 Q8NAK1

Explore the universe of human proteins at neXtProt for MUC6: NX_Q6W4X9

Explore proteomics data for MUC6 at MOPED

Post-translational modifications:

UniProtKB: O-glycosylated

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6W4X9

MUC6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005952.2

ENSEMBL proteins:

ENSP00000406861 ENSP00000433246 ENSP00000436903 ENSP00000433790

Reactome Protein details: Q6W4X9
Human Recombinant Protein Products for MUC6:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for MUC6
	GenScript Custom Purified and Recombinant Proteins Services for MUC6
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MUC6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005796	Golgi lumen	TAS	--

MUC6 for ontologies About GeneDecksing

MUC6 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MUC6
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MUC6
	GenScript Custom Superior Antibodies Services for MUC6
	Novus Biologicals MUC6 Antibodies
	Abcam antibodies for MUC6
	Cloud-Clone Corp. Antibodies for MUC6
	ThermoFisher Antibody for MUC6
	LSBio Antibodies in human, mouse, rat for MUC6

Assay Products for MUC6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MUC6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MUC6
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MUC6 Cloud-Clone Corp. CLIAs for MUC6

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

MUC: Mucins

4 InterPro protein domains:

IPR014853 Unchr_dom_Cys-rich

IPR006207 Cys_knot_C

IPR002919 TIL_dom

IPR001846 VWF_type-D

Graphical View of Domain Structure for InterPro Entry Q6W4X9

ProtoNet protein and cluster: Q6W4X9

1 Blocks protein domain: IPB002919 Trypsin inhibitor-like

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain

Similarity: Contains 1 TIL (trypsin inhibitory-like) domain

Similarity: Contains 3 VWFD domains

MUC6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MUC6_HUMAN, Q6W4X9

Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid

secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection

of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial

organogenesis

Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors

Genatlas biochemistry entry for MUC6:

mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	7680650

MUC6 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for MUC6

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MUC6

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MUC6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MUC6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MUC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC6
		Sirion Biotech Custom design and validation of potent shRNA sequences against MUC6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MUC6
			Sirion Biotech Customized adenovirus for potent knockdown of MUC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for MUC6 (see all 5) OriGene ORF clones in mouse, rat for MUC6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MUC6 (NM_005961)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC6
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MUC6
		Search LifeMap BioReagents cell lines for MUC6
		Sirion Biotech Customized stable knockdown cell line services for MUC6 Customized inducible knockdown cell line services for MUC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MUC6 About

See pathways by source

SuperPath

Contained pathways About

O-linked glycosylation of mucins

O-linked glycosylation of mucins

0.44

Termination of O-glycan biosynthesis

0.41

Asparagine N-linked glycosylation

Post-translational protein modification

0.44

Metabolism of proteins

0.35

Pathways by source See SuperPaths
Show all pathways

4 Reactome Pathways for MUC6

	O-linked glycosylation of mucins
	Metabolism of proteins
	Post-translational protein modification
	Termination of O-glycan biosynthesis

MUC6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MUC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for MUC6 (Q6W4X9³ ENSP00000406861⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TFF1	P04155³, ENSP00000291527⁴	I2D: score=1 STRING: ENSP00000291527
B3GNT3	ENSP00000321874⁴	STRING: ENSP00000321874
C1GALT1	ENSP00000223122⁴	STRING: ENSP00000223122
C1GALT1C1	ENSP00000304364⁴	STRING: ENSP00000304364
GALNT1	ENSP00000269195⁴	STRING: ENSP00000269195

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016266	O-glycan processing	TAS	--
GO:0030277	maintenance of gastrointestinal epithelium	NAS	7680650
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

MUC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MUC6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MUC6

8 Novoseek inferred chemical compound relationships for MUC6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin	5.55	1	11253133 (1)
calcium	3.04	2	12517055 (2)
cholesterol	0	3	12517055 (2), 14634353 (1)
oligonucleotide	0	1	11673830 (1)
progesterone	0	2	15086841 (1), 15737028 (1)
estrogen	0	4	15737028 (2), 15086841 (1), 9650551 (1)
polysaccharide	0	1	14632674 (1)
5fluorouracil	0	1	14576935 (1)

Search CenterWatch for drugs/clinical trials and news about MUC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MUC6 gene:

NM_005961.2

Unigene Cluster for MUC6:

Mucin 6, oligomeric mucus/gel-forming

Hs.528432 [show with all ESTs]

Unigene Representative Sequence: NM_005961

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421673(uc001lsw.2) ENST00000532016 ENST00000527242 ENST00000525923

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MUC6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MUC6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MUC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC6
		Sirion Biotech Custom design and validation of potent shRNA sequences against MUC6

Clone Products:		OriGene clones in human, mouse for MUC6 (see all 5) OriGene ORF clones in mouse, rat for MUC6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MUC6 (NM_005961)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC6
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MUC6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MUC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC6

Additional mRNA sequence:

AK092533.1 AK096772.1 AK098503.1 AY312160.1 AY458429.1 U97698.1

9 DOTS entries:

DT.97847590 DT.120730951 DT.95288353 DT.91682232 DT.120730948 DT.91750804 DT.95341118 DT.75101750

DT.87002890

24/83 AceView cDNA sequences (see all 83):

BM798703 BM767214 BQ082919 BM768868 BM856626 AI420483 BM818289 BM773508

BM773490 AA687898 BQ084019 BM794541 BM768831 AA588236 AI732669 BM769894

AW130323 BM823251 BM773506 BM856696 BM769293 AI868225 BM823214 AK098503

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MUC6 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:							-
SP2:					-

ECgene alternative splicing isoforms for MUC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MUC6 expression in normal human tissues (normalized intensities) MUC6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGAACGTGA

About this image

MUC6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Reproductive System (Reproductive System)
cervix, uterine ; glandular cells

Testis (Reproductive System)
seminal vesicle ; glandular cells

Pancreas (Endocrine System)
pancreas ; exocrine glandular cells

Gall Bladder (Hepatobiliary System)
gallbladder ; glandular cells

Endoderm (Gastrulation Derivatives)
Endoderm progenitor-like cells (Generation and expansion of endodermal progenitor...

See MUC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC6

SOURCE GeneReport for Unigene cluster: Hs.528432

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura

mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric

epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar

cells and ducts, and periductal glands of the common bile duct

SABiosciences Custom PCR Arrays for MUC6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MUC6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MUC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MUC6 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Muc6^{1 , 5}	mucin 6, gastric^{1, 5}	66.88(n)¹ 60.8(a)¹		7 (87.03 cM)⁵ 353328¹ NM_181729.2¹ NP_859418.1¹ 141634049⁵
chicken (Gallus gallus)	Aves	MUC6¹	mucin 6, oligomeric mucus/gel-forming	57.05(n) 55.52(a)		414878 XM_426405.3 XP_426405.3
lizard (Anolis carolinensis)	Reptilia	MUC6⁶	Uncharacterized protein	53(a)	1 ↔ 1	1(72416633-72464090)
fruit fly (Drosophila melanogaster)	Insecta	Hml⁶	Hemolectin	9(a)	1 → many	3L(13839154-13853101)

ENSEMBL Gene Tree for MUC6 (if available)
TreeFam Gene Tree for MUC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MUC6 gene

MUC5AC² ZAN² TECTA² OTOG² OTOGL² MUC5B² MUC19² FCGBP²

VWF² BMPER²

MUC6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Polymorphism: The number of repeats is highly polymorphic and varies among different alleles. These repeats are very

similar but not identical

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113559934^1,2	C,F	untested¹	1016910(+)	`AGGGTG/ATGGGT`	2	/T /I	mis¹		3		NA CSA	6
rs78819924^1,2	C	untested¹	1017789(+)	`GCGTCA/CTTGTT`	2	R M	mis¹		0	--	--	--	--
rs148581741^1,2	C	untested¹	1018419(+)	`TGACTA/GTGTGA`	2	T I	mis¹		0	--	--	--	--
rs141051167^1,2	C	--	1012837(+)	`AAGAAC/GCGGTT`	1	--	ut3¹		0	--	--	--	--
rs144864529^1,2		--	1012867(+)	`GGTGAC/TGCCCT`	1	--	ut3¹		0	--	--	--	--
rs79941751^1,2	F	--	1012970(+)	`ACCCTC/TTGCCC`	1	--	ut3¹		1		EA	120
rs200449914^1,2	C	--	1012985(-)	`CCCCAA/GAGTCA`	1	--	ut3¹		0	--	--	--	--
rs147608243^1,2	C	--	1012993(+)	`GGGAT-/CTCCTCTT`	1	--	cds¹		0	--	--	--	--
rs187110573^1,2		--	1012996(+)	`ATCTCC/TTCTTC`	1	--	ut3¹		0	--	--	--	--
rs192076984^1,2		--	1013064(+)	`CTCCTC/TGCCCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MUC6 (1012821 - 1036706 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/33 variations for MUC6 (see all 33): About this table

Variant ID	Type	Subtype	PubMed ID
esv2743883	CNV	Deletion	23290073
esv2743878	CNV	Deletion	23290073
esv2743884	CNV	Deletion	23290073
esv2669189	CNV	Deletion	23128226
nsv820593	CNV	Duplication	20802225
esv1474704	CNV	Insertion	17803354
nsv59	CNV	Insertion	15895083
nsv7637	CNV	Insertion	18451855
esv988598	CNV	Insertion	20482838
nsv469923	CNV	Loss	18288195

Human Gene Mutation Database (HGMD): MUC6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC6

DNA2.0 Custom Variant and Variant Library Synthesis for MUC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MUC6 for disorders           About GeneDecksing

OMIM gene information: 158374    OMIM disorders: --

20/43 diseases for MUC6 (see all 43):    About MalaCards

gastroduodenitis epstein-barr virus-associated gastric carcinoma biliary papillomatosis pancreatic ductal carcinoma

ampulla of vater carcinoma barrett's esophagus endocervicitis pseudomyxoma peritonei

h. pylori infection duodenal ulcer atrophic gastritis duodenitis

gastritis cholecystitis mucoepidermoid carcinoma familial adenomatous polyposis

bile duct carcinoma stomach cancer otitis media cystadenoma

5 diseases from the University of Copenhagen DISEASES database for MUC6:

Carcinoma Adenoma Biliary papillomatosis Pseudomyxoma peritonei

Gastritis

10/38 Novoseek inferred disease relationships for MUC6 gene (see all 38) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric carcinoma	73.9	37	15737028 (4), 11745219 (3), 15354218 (2), 12719460 (2) (see all 21)
metaplasia	72.7	27	10070955 (4), 14508397 (3), 16545139 (2), 11093805 (1) (see all 10)
carcinoma mucinous	72.5	7	12493022 (4), 15976813 (1), 18493590 (1)
adenocarcinoma	61.2	29	15753982 (5), 19094709 (2), 14623937 (2), 15086835 (2) (see all 16)
carcinoma	57.3	17	15260848 (3), 11253133 (2), 15071739 (2), 16135257 (2) (see all 11)
adenoma	56.5	23	19855374 (6), 9935202 (3), 17085661 (2), 15260848 (2) (see all 8)
carcinoma bronchioloalveolar	52.2	5	11274635 (2), 15151204 (2)
dysplasia	50.2	16	9935202 (3), 18097286 (2), 16949933 (2), 15260848 (2) (see all 7)
carcinoma pancreatic ductal	50	1	16018800 (1)
gastric polyp	48.2	2	10398119 (1), 10699992 (1)

Genetic Association Database (GAD): MUC6
Human Genome Epidemiology (HuGE) Navigator: MUC6 (9 documents)

Export disorders for MUC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MUC6 gene, integrated from 9 sources (see all 212):
(articles sorted by number of sources associating them with MUC6)

Utopia: connect your pdf to the dynamic
world of online information

Human gastric mucin. Identification of a unique species by expression cloning. (PubMed id 7680650)^{1, 2, 3} Toribara N.W.... Kim Y.S. (1993)
Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PubMed id 15280409)^{1, 2, 9} Xia H.H.-X.... Wong B.C.-Y. (2004)
Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PubMed id 11988092)^{1, 2, 9} Nordman H....Carlstedt I. (2002)
Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PubMed id 15979574)^{1, 2, 9} Sakai H.... Yuasa Y. (2005)
The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)^{1, 2, 9} Rousseau K....Toribara N.W. (2004)
The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PubMed id 9195947)^{1, 2, 9} Toribara N.W.... Kim Y.S. (1997)
Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. (PubMed id 9422745)^{1, 2, 9} Debailleul V.... Porchet N. (1998)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (2010)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (2010)
Short rare MUC6 minisatellites-5 alleles influence su sceptibility to gastric carcinoma by regulating gene. (PubMed id 20506113)^{1, 4} Kwon J.A....Leem S.H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4588	HGNC: 7517	AceView: MUC6	Ensembl:ENSG00000184956	euGenes: HUgn4588
ECgene: MUC6	H-InvDB: MUC6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MUC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MUC6	Genetics and Cytogenetics in Oncology and Haematology
Mucin database	http://www.medkem.gu.se/mucinbiology/databases/

Intellectual Property for MUC6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MUC6 gene:
Search GeneIP for patents involving MUC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MUC6
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MUC6
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for MUC6
	OriGene qSTAR qPCR primer pairs in human, mouse for MUC6		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for MUC6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MUC6		OriGene Custom Protein Services for MUC6

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MUC6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MUC6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC6

	GenScript Custom Purified and Recombinant Proteins Services for MUC6		GenScript cDNA clones with any tag delivered in your preferred vector for MUC6
	GenScript Custom Assay Services for MUC6		GenScript Custom Superior Antibodies Services for MUC6
	GenScript Custom overexpressing Cell Line Services for MUC6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MUC6 promoter
	Search Chromatin IP Primers for MUC6
	RT² qPCR Primer Assay in human, mouse, rat MUC6
	Search GNC Networks for MUC6
	SABiosciences Custom PCR Arrays for MUC6

Search Tocris compounds for MUC6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MUC6 antibodies

	Antibodies for MUC6
	See all of Abcam's Antibodies, Kits and Proteins for MUC6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MUC6
	Antibodies for MUC6
	ELISAs for MUC6
	CLIAs for MUC6

Search LifeMap BioReagents cell lines for MUC6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MUC6
	Browse SwitchGear Promoter luciferase reporter plasmids for MUC6

ThermoFisher Antibody for MUC6

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC6

	inGenious Targeting Laboratory - Custom generated mouse model solutions for MUC6
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MUC6

Customized:

	stable knockdown cell line services for MUC6
	inducible knockdown cell line services for MUC6
	design and validation of potent shRNA sequences against MUC6
	adenovirus for potent knockdown of MUC6
	stable overexpressing cell line services
	inducible overexpressing cell line services
	adenovirus for overexpression

LSBio Antibodies in human, mouse, rat for MUC6

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MUC6 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MUC6 Gene

Mucin 6, Oligomeric Mucus/Gel-Forming

Aliases
for MUC6 gene

Summaries
for MUC6 gene

Genomic Views
for MUC6 gene

Proteins
for MUC6 gene

Protein Domains /
Families
for MUC6 gene

Function
for MUC6 gene

Pathways & Interactions
for MUC6 gene

Drugs & Compounds
for MUC6 gene

Transcripts
for MUC6 gene

Expression
for MUC6 gene

Orthologs
for MUC6 gene

Paralogs
for MUC6 gene

Genomic Variants
for MUC6 gene

Disorders / Diseases
for MUC6 gene

Publications
for MUC6 gene

External Searches for MUC6 gene

Genome Databases showing MUC6 gene

Other Databases showing MUC6 gene

Specialized Databases showing MUC6 gene

Intellectual Property
for MUC6 gene

Products
for MUC6 gene

View Random Gene

Barrett Esophagus
Gastric Cancer
BREAST CARCINOMA
familial adenomatous polyposis
Microsatellite Instability
Adenomatous Polyps
Hyperplasia
dysplasia
Cystic Fibrosis
Carcinoma
Polyps
epithelial tumor
Breast Cancer
biliary obstruction
Metaplasia
Carcinoma Pancreatic Ductal
Carcinoma Bronchioloalveolar
Adenocarcinoma
GASTRIC POLYP
Cancer
Obstruction
Colorectal Carcinoma
chronic pancreatitis
GASTRIC CARCINOMA
effusion
Carcinoma Mucinous
Colorectal Neoplasms
Pancreatic tumor
Adenoma
Colorectal Cancer
Inflammation
Carcinoma Squamous Cell
Gastritis
Tumors
Metastasis
Carcinoma Ductal
Necrosis
Duodenal Ulcer

Advanced Search

Export list of displayed genes

MUC6 Gene

Mucin 6, Oligomeric Mucus/Gel-Forming

Aliasesfor MUC6 gene

Summariesfor MUC6 gene

Genomic Viewsfor MUC6 gene

Proteinsfor MUC6 gene

Protein Domains /Familiesfor MUC6 gene

Functionfor MUC6 gene

Pathways & Interactionsfor MUC6 gene

Drugs & Compoundsfor MUC6 gene

Transcriptsfor MUC6 gene

Expression for MUC6 gene

Orthologsfor MUC6 gene

Paralogsfor MUC6 gene

Genomic Variantsfor MUC6 gene

Disorders / Diseasesfor MUC6 gene

Publicationsfor MUC6 gene

External Searches for MUC6 gene

Genome Databases showing MUC6 gene

Other Databases showing MUC6 gene

Specialized Databases showing MUC6 gene

Intellectual Propertyfor MUC6 gene

Productsfor MUC6 gene

View Random Gene

Aliases
for MUC6 gene

Summaries
for MUC6 gene

Genomic Views
for MUC6 gene

Proteins
for MUC6 gene

Protein Domains /
Families
for MUC6 gene

Function
for MUC6 gene

Pathways & Interactions
for MUC6 gene

Drugs & Compounds
for MUC6 gene

Transcripts
for MUC6 gene

Expression
for MUC6 gene

Orthologs
for MUC6 gene

Paralogs
for MUC6 gene

Genomic Variants
for MUC6 gene

Disorders / Diseases
for MUC6 gene

Publications
for MUC6 gene

Intellectual Property
for MUC6 gene

Products
for MUC6 gene