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MUC6 Gene

protein-coding GIFtS: 57
GCID: GC11M001002

Mucin 6, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 6, gastric)

See MUC6-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Mucin 6, Oligomeric Mucus/Gel-Forming¹ ²
Mucin 6, Gastric¹ ²
Gastric Mucin-6² ³
MUC-6² ³
mucin-6²

External Ids:	HGNC: 7517¹	Entrez Gene: 4588²	Ensembl: ENSG00000184956⁷	OMIM: 158374⁵	UniProtKB: Q6W4X9³

Export aliases for MUC6 gene to outside databases

Previous GC identifers: GC11U990090 GC11P000176 GC11M001008 GC11M000974 GC11M000828

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MUC6 Gene:

The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial

cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal

tract (summary by Toribara et al., 1993 (PubMed 7680650)).(supplied by OMIM, Dec 2010)

GeneCards Summary for MUC6 Gene:

MUC6 (mucin 6, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC6 include epstein-barr virus-associated gastric carcinoma, and biliary papillomatosis. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid

secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the

cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in

epithelial organogenesis

Gene Wiki entry for MUC6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NT_187656.1 NT_187681.1 NC_000011.9 NC_018922.2 NT_009237.19

Regulatory elements:

Regulatory transcription factor binding sites in the MUC6 gene promoter:
p53 Sp1 Olf-1 Tal-1beta LCR-F1 NF-kappaB1 E47
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for MUC6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

MUC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC6 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M001002: view genomic region (about GC identifiers)

Start:	1,012,821 bp from pter	End:	1,036,706 bp from pter
Size:	23,886 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9 (See protein sequence)

Recommended Name: Mucin-6 precursor

Size: 2439 amino acids; 257051 Da

Subunit: Multimer; disulfide-linked

Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic

ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic

zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13

weeks and at lower levels from 17 to 23 weeks of gestation

Sequence caution: Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu;

Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: O15329 Q14394 Q2TUQ5 Q4L207 Q8N8I1 Q8NAK1

Explore the universe of human proteins at neXtProt for MUC6: NX_Q6W4X9

Explore proteomics data for MUC6 at MOPED

Post-translational modifications:

O-glycosylated¹

Glycosylation² at Asn268, Asn486, Asn659, Asn975, Asn1179, Asn2366

See MUC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005952.2

ENSEMBL proteins:

ENSP00000406861 ENSP00000433246 ENSP00000436903 ENSP00000433790

Reactome Protein details: Q6W4X9

MUC6 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

MUC: Mucins

4 InterPro protein domains:

IPR014853 Unchr_dom_Cys-rich

IPR006207 Cys_knot_C

IPR002919 TIL_dom

IPR001846 VWF_type-D

Graphical View of Domain Structure for InterPro Entry Q6W4X9

ProtoNet protein and cluster: Q6W4X9

1 Blocks protein domain: IPB002919 Trypsin inhibitor-like

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain

Similarity: Contains 1 TIL (trypsin inhibitory-like) domain

Similarity: Contains 3 VWFD domains

Find genes that share domains with MUC6 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MUC6_HUMAN, Q6W4X9

Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid

secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the

cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in

epithelial organogenesis

Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription

factors

Genatlas biochemistry entry for MUC6:

mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	7680650

Find genes that share ontologies with MUC6 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for MUC6

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MUC6_HUMAN, Q6W4X9: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
golgi apparatus	4
plasma membrane	2
cytoskeleton	1
cytosol	1
lysosome	1
mitochondrion	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005796	Golgi lumen	TAS	--

Find genes that share ontologies with MUC6 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MUC6 About

See pathways by source

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SuperPath

Contained pathways About

O-linked glycosylation of mucins

O-linked glycosylation of mucins

0.47

Termination of O-glycan biosynthesis

0.38

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Post-translational protein modification

0.43

Metabolism of proteins

0.30

Find genes that share SuperPaths with MUC6 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for MUC6

	O-linked glycosylation of mucins
	Termination of O-glycan biosynthesis

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MUC6
Interactions:

Search GeneGlobe Interaction Network for MUC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MUC6 (Q6W4X9³ ENSP00000406861⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TFF1	P04155³, ENSP00000291527⁴	I2D: score=1 STRING: ENSP00000291527
B3GNT3	ENSP00000321874⁴	STRING: ENSP00000321874
C1GALT1	ENSP00000223122⁴	STRING: ENSP00000223122
C1GALT1C1	ENSP00000304364⁴	STRING: ENSP00000304364
GALNT1	ENSP00000269195⁴	STRING: ENSP00000269195

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016266	O-glycan processing	TAS	--
GO:0030277	maintenance of gastrointestinal epithelium	NAS	7680650
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MUC6

8 Novoseek inferred chemical compound relationships for MUC6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin	5.55	1	11253133 (1)
calcium	3.04	2	12517055 (2)
cholesterol	0	3	12517055 (2), 14634353 (1)
oligonucleotide	0	1	11673830 (1)
progesterone	0	2	15086841 (1), 15737028 (1)
estrogen	0	4	15737028 (2), 15086841 (1), 9650551 (1)
polysaccharide	0	1	14632674 (1)
5fluorouracil	0	1	14576935 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MUC6 gene:

NM_005961.2

Unigene Cluster for MUC6:

Mucin 6, oligomeric mucus/gel-forming

Hs.528432 [show with all ESTs]

Unigene Representative Sequence: NM_005961

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421673(uc001lsw.2) ENST00000532016 ENST00000527242 ENST00000525923

miRNA Products:		Block miRNA regulation of human, mouse, rat MUC6 using miScript Target Protectors
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Additional mRNA sequence:

AK092533.1 AK096772.1 AK098503.1 AY312160.1 AY458429.1 U97698.1

9 DOTS entries:

DT.97847590 DT.120730951 DT.95288353 DT.91682232 DT.120730948 DT.91750804 DT.95341118 DT.75101750

DT.87002890

Selected AceView cDNA sequences (see all 83):

AA588236 BM856696 BM769894 BM768868 BM769293 BM773490 AI420483 BQ082919

BM798703 AI732669 BM773506 AA687898 BM773508 BM767214 BM856626 BM768831

BQ084019 AI868225 BM823251 AW130323 BM818289 BM794541 BM823218 BM790820

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MUC6 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:							-
SP2:					-

ECgene alternative splicing isoforms for MUC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MUC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGAACGTGA

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MUC6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


NULL (Uncategorized)
Endoderm progenitor-like cells

Stomach (Gastrointestinal Tract)

MUC6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MUC6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.528432

UniProtKB/Swiss-Prot: MUC6_HUMAN, Q6W4X9

Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura

mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected

gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic

centroacinar cells and ducts, and periductal glands of the common bile duct

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MUC6 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Muc6^{1 , 5}	mucin 6, gastric^{1, 5}	75.09(n)¹ 70.97(a)¹		7 (87.03 cM)⁵ 353328¹ NM_181729.2¹ NP_859418.1¹ 141634049⁵
chicken (Gallus gallus)	Aves	MUC6⁶	mucin 6, oligomeric mucus/gel-forming	38(a)	1 ↔ 1	5(14423044-14459159) ENSGALG00000020492
lizard (Anolis carolinensis)	Reptilia	MUC6⁶	mucin 6, oligomeric mucus/gel-forming	56(a)	1 ↔ 1	1(72416633-72464090)

ENSEMBL Gene Tree for MUC6 (if available)
TreeFam Gene Tree for MUC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MUC6 gene

MUC5AC² ZAN² TECTA² MUC2² OTOG² OTOGL² MUC19² FCGBP²

VWF² BMPER²

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot

MUC6_HUMAN, Q6W4X9: The number of repeats is highly polymorphic and varies among different alleles. These repeats are

very similar but not identical

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113559934^1,2	C,F	untested¹	1016910(+)	`AGGGTG/ATGGGT`	2	/T /I	mis¹		3		NA CSA	6
rs78819924^1,2	C	untested¹	1017789(+)	`GCGTCA/CTTGTT`	2	R M	mis¹		0	--	--	--	--
rs148581741^1,2	C	untested¹	1018419(+)	`TGACTA/GTGTGA`	2	T I	mis¹		0	--	--	--	--
rs141051167^1,2	C	--	1012837(+)	`AAGAAC/GCGGTT`	1	--	ut3¹		0	--	--	--	--
rs144864529^1,2		--	1012867(+)	`GGTGAC/TGCCCT`	1	--	ut3¹		0	--	--	--	--
rs79941751^1,2	F	--	1012970(+)	`ACCCTC/TTGCCC`	1	--	ut3¹		1		EA	120
rs200449914^1,2	C	--	1012985(-)	`CCCCAA/GAGTCA`	1	--	ut3¹		0	--	--	--	--
rs147608243^1,2	C	--	1012993(+)	`GGGAT-/CTCCTCTT`	1	--	cds¹		0	--	--	--	--
rs187110573^1,2		--	1012996(+)	`ATCTCC/TTCTTC`	1	--	ut3¹		0	--	--	--	--
rs192076984^1,2		--	1013064(+)	`CTCCTC/TGCCCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MUC6 (1012821 - 1036706 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for MUC6 (see all 33): About this table

Variant ID	Type	Subtype	PubMed ID
esv2743883	CNV	Deletion	23290073
esv2743878	CNV	Deletion	23290073
esv2743884	CNV	Deletion	23290073
esv2669189	CNV	Deletion	23128226
nsv820593	CNV	Duplication	20802225
esv1474704	CNV	Insertion	17803354
nsv59	CNV	Insertion	15895083
nsv7637	CNV	Insertion	18451855
esv988598	CNV	Insertion	20482838
nsv469923	CNV	Loss	18288195

Human Gene Mutation Database (HGMD): MUC6

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MUC6

DNA2.0 Custom Variant and Variant Library Synthesis for MUC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 158374 OMIM disorders: --

7 diseases for MUC6:
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epstein-barr virus-associated gastric carcinoma biliary papillomatosis pseudomyxoma peritonei endocervical adenocarcinoma

pancreatic ductal carcinoma h. pylori infection duodenal ulcer

5 inferred disease relationships from the University of Copenhagen DISEASES database for MUC6:

Carcinoma Adenoma Biliary papillomatosis Pseudomyxoma peritonei

Gastritis

Find genes that share disorders with MUC6 About GenesLikeMe

Selected Novoseek inferred disease relationships for MUC6 gene (see all 38) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric carcinoma	73.9	37	15737028 (4), 11745219 (3), 15354218 (2), 12719460 (2) (see all 21)
metaplasia	72.7	27	10070955 (4), 14508397 (3), 16545139 (2), 11093805 (1) (see all 10)
carcinoma mucinous	72.5	7	12493022 (4), 15976813 (1), 18493590 (1)
adenocarcinoma	61.2	29	15753982 (5), 19094709 (2), 14623937 (2), 15086835 (2) (see all 16)
carcinoma	57.3	17	15260848 (3), 11253133 (2), 15071739 (2), 16135257 (2) (see all 11)
adenoma	56.5	23	19855374 (6), 9935202 (3), 17085661 (2), 15260848 (2) (see all 8)
carcinoma bronchioloalveolar	52.2	5	11274635 (2), 15151204 (2)
dysplasia	50.2	16	9935202 (3), 18097286 (2), 16949933 (2), 15260848 (2) (see all 7)
carcinoma pancreatic ductal	50	1	16018800 (1)
gastric polyp	48.2	2	10398119 (1), 10699992 (1)

Genetic Association Database (GAD): MUC6
Human Genome Epidemiology (HuGE) Navigator: MUC6 (9 documents)

Export disorders for MUC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MUC6 gene, integrated from 10 sources (see all 213):
(articles sorted by number of sources associating them with MUC6)

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Human gastric mucin. Identification of a unique species by expression cloning. (PubMed id 7680650)^{1, 2, 3} Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1993)
Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PubMed id 15280409)^{1, 2, 9} Xia H.H.-X.... Wong B.C.-Y. (J. Clin. Pathol. 2004)
Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PubMed id 11988092)^{1, 2, 9} Nordman H....Carlstedt I. (Biochem. J. 2002)
Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PubMed id 15979574)^{1, 2, 9} Sakai H.... Yuasa Y. (Biochem. Biophys. Res. Commun. 2005)
The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PubMed id 15081123)^{1, 2, 9} Rousseau K....Toribara N.W. (Genomics 2004)
The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PubMed id 9195947)^{1, 2, 9} Toribara N.W.... Kim Y.S. (J. Biol. Chem. 1997)
Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. (PubMed id 9422745)^{1, 2, 9} Debailleul V.... Porchet N. (J. Biol. Chem. 1998)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma by regulating gene. (PubMed id 20506113)^{1, 4} Kwon J.A....Leem S.H. (Hum. Mutat. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4588	HGNC: 7517	AceView: MUC6	Ensembl:ENSG00000184956	euGenes: HUgn4588
ECgene: MUC6	H-InvDB: MUC6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MUC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MUC6	Genetics and Cytogenetics in Oncology and Haematology
Mucin database	http://www.medkem.gu.se/mucinbiology/databases/

Intellectual Property for MUC6 gene
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MUC6 Gene

Mucin 6, Oligomeric Mucus/Gel-Forming

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Barrett Esophagus
Gastric Cancer
BREAST CARCINOMA
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MUC6 Gene

Mucin 6, Oligomeric Mucus/Gel-Forming

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