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Aliases for MUC5B Gene

Aliases for MUC5B Gene

  • Mucin 5B, Oligomeric Mucus/Gel-Forming 2 3
  • High Molecular Weight Salivary Mucin MG1 3 4
  • Mucin 5, Subtype B, Tracheobronchial 2 3
  • Sublingual Gland Mucin 3 4
  • MUC-5B 3 4
  • MUC5 3 4
  • Mucin-5 Subtype B, Tracheobronchial 4
  • Cervical Mucin MUC5B 3
  • Cervical Mucin 4
  • MUC9 3
  • MG1 3

External Ids for MUC5B Gene

Previous HGNC Symbols for MUC5B Gene

  • MUC5

Previous GeneCards Identifiers for MUC5B Gene

  • GC11P001736
  • GC11P001535
  • GC11P001210
  • GC11P001211
  • GC11P001200
  • GC11P001145
  • GC11P001037

Summaries for MUC5B Gene

Entrez Gene Summary for MUC5B Gene

  • This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

GeneCards Summary for MUC5B Gene

MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include panbronchiolitis, diffuse and pulmonary fibrosis, idiopathic. Among its related pathways are Transport to the Golgi and subsequent modification and Salivary secretion.

UniProtKB/Swiss-Prot for MUC5B Gene

  • Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus

Gene Wiki entry for MUC5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC5B Gene

Genomics for MUC5B Gene

Regulatory Elements for MUC5B Gene

Genomic Location for MUC5B Gene

1,223,065 bp from pter
1,262,176 bp from pter
39,112 bases
Plus strand

Genomic View for MUC5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC5B Gene

Proteins for MUC5B Gene

  • Protein details for MUC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O00447
    • O00573
    • O14985
    • O15494
    • O95291
    • O95451
    • Q14881
    • Q7M4S5
    • Q99552
    • Q9UE28

    Protein attributes for MUC5B Gene

    5762 amino acids
    Molecular mass:
    596340 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA06167.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MUC5B Gene

Proteomics data for MUC5B Gene at MOPED

Post-translational modifications for MUC5B Gene

  • Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol.
  • Glycosylation at Asn 145, Asn 201, Asn 254, Asn 401, Asn 515, Asn 805, Asn 929, Asn 1276, Asn 1292, Trp 1340, Trp 1509, Asn 1556, Asn 1774, Trp 1790, Trp 2320, Asn 2749, Trp 2877, Asn 3449, Trp 3577, Asn 4006, Trp 4134, Asn 4804, Asn 4960, Asn 5017, Asn 5024, Asn 5046, Asn 5096, Asn 5111, Asn 5215, Asn 5486, Asn 5526, Asn 5565, Asn 5566, Asn 5602, Asn 5612, Asn 5663, Asn 5677, and Asn 5721
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MUC5B Gene

Domains & Families for MUC5B Gene

Gene Families for MUC5B Gene


Suggested Antigen Peptide Sequences for MUC5B Gene

Graphical View of Domain Structure for InterPro Entry



  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
  • Contains 3 HAT repeats.
  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 3 TIL (trypsin inhibitory-like) domains.
  • Contains 3 VWFC domains.
  • Contains 4 VWFD domains.
  • Contains 3 HAT repeats.
genes like me logo Genes that share domains with MUC5B: view

Function for MUC5B Gene

Molecular function for MUC5B Gene

GENATLAS Biochemistry:
mucin 5B,belonging to the secreted mucins cluster,expressed in tracheobronchial tissues,submaxillary glands,gall bladder and endocervix
UniProtKB/Swiss-Prot Function:
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus
UniProtKB/Swiss-Prot Induction:
Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.

Gene Ontology (GO) - Molecular Function for MUC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 1718282
genes like me logo Genes that share ontologies with MUC5B: view

Phenotypes for MUC5B Gene

genes like me logo Genes that share phenotypes with MUC5B: view

Animal Model Products

CRISPR Products

miRNA for MUC5B Gene

miRTarBase miRNAs that target MUC5B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC5B Gene

Localization for MUC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC5B Gene


Subcellular locations from

Jensen Localization Image for MUC5B Gene COMPARTMENTS Subcellular localization image for MUC5B gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MUC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005796 Golgi lumen TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MUC5B: view

Pathways & Interactions for MUC5B Gene

genes like me logo Genes that share pathways with MUC5B: view

Interacting Proteins for MUC5B Gene

Gene Ontology (GO) - Biological Process for MUC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0042742 defense response to bacterium IEA --
GO:0043030 regulation of macrophage activation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MUC5B: view

No data available for SIGNOR curated interactions for MUC5B Gene

Drugs & Compounds for MUC5B Gene

No Compound Related Data Available

Transcripts for MUC5B Gene

mRNA/cDNA for MUC5B Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC5B Gene

Mucin 5B, oligomeric mucus/gel-forming:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC5B Gene

No ASD Table

Relevant External Links for MUC5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC5B Gene

mRNA expression in normal human tissues for MUC5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC5B Gene

This gene is overexpressed in Minor Salivary Gland (x30.6) and Cervix - Endocervix (x13.8).

Protein differential expression in normal tissues from HIPED for MUC5B Gene

This gene is overexpressed in Saliva (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MUC5B Gene

SOURCE GeneReport for Unigene cluster for MUC5B Gene Hs.523395

mRNA Expression by UniProt/SwissProt for MUC5B Gene

Tissue specificity: Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.
genes like me logo Genes that share expression patterns with MUC5B: view

Protein tissue co-expression partners for MUC5B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for MUC5B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC5B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MUC5B 35
  • 70.49 (n)
  • 63.33 (a)
(Mus musculus)
Mammalia Muc5b 35
  • 67.89 (n)
  • 61.56 (a)
Muc5b 16
Muc5b 36
  • 41 (a)
(Rattus norvegicus)
Mammalia Muc5b 35
  • 67.07 (n)
  • 61.09 (a)
(Bos Taurus)
Mammalia MUC5B 36
  • 36 (a)
(Monodelphis domestica)
Mammalia MUC5B 36
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia MUC5B 36
  • 30 (a)
(Gallus gallus)
Aves LOC100859916 35
  • 56.2 (n)
  • 51.49 (a)
MUC5B 36
  • 31 (a)
(Anolis carolinensis)
Reptilia MUC5B 36
  • 44 (a)
(Danio rerio)
Actinopterygii muc5b 36
  • 20 (a)
MUC5B (2 of 4) 36
  • 26 (a)
MUC5B (3 of 4) 36
  • 22 (a)
muc5f 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
-- 36
  • 14 (a)
Species with no ortholog for MUC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC5B Gene

Gene Tree for MUC5B (if available)
Gene Tree for MUC5B (if available)

Paralogs for MUC5B Gene

(4) SIMAP similar genes for MUC5B Gene using alignment to 6 proteins: Pseudogenes for MUC5B Gene

genes like me logo Genes that share paralogs with MUC5B: view

No data available for Paralogs for MUC5B Gene

Variants for MUC5B Gene

Sequence variations from dbSNP and Humsavar for MUC5B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs760415 -- 1,231,843(+) CCCCC(C/G)CCCAG intron-variant
rs760416 -- 1,232,115(+) CCAAT(G/T)CCAGG reference, missense
rs760417 -- 1,232,727(+) TGTGC(C/G)CCCAA frameshift-variant, reference
rs762818 -- 1,261,182(+) CAGAA(A/G/T)ACAGA intron-variant
rs868902 -- 1,221,278(+) CCATG(A/C)AACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MUC5B Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
essv22587 CNV CNV 17122850
nsv896644 CNV Loss 21882294
dgv962n71 CNV Loss 21882294
dgv963n71 CNV Loss 21882294
dgv964n71 CNV Loss 21882294
dgv965n71 CNV Loss 21882294
dgv966n71 CNV Loss 21882294
dgv967n71 CNV Loss 21882294
dgv968n71 CNV Loss 21882294
nsv8763 CNV Gain 18304495
nsv524071 CNV Loss 19592680
dgv969n71 CNV Loss 21882294
dgv970n71 CNV Loss 21882294
esv26924 CNV Loss 19812545
nsv467637 CNV Loss 19166990
esv1522213 CNV Deletion 17803354
dgv971n71 CNV Loss 21882294
esv2743906 CNV Deletion 23290073

Variation tolerance for MUC5B Gene

Residual Variation Intolerance Score: 99.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.99; 98.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC5B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC5B Gene

Disorders for MUC5B Gene

MalaCards: The human disease database

(37) MalaCards diseases for MUC5B Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
panbronchiolitis, diffuse
  • diffuse panbronchiolitis
pulmonary fibrosis, idiopathic
  • idiopathic pulmonary fibrosis
encapsulated thymoma
  • acute pneumonia
respiratory system disease
  • respiration disorders
- elite association
Search MUC5B in MalaCards View complete list of genes associated with diseases


  • Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. {ECO:0000269 PubMed:21506741, ECO:0000269 PubMed:21506748}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741). {ECO:0000269 PubMed:21506741}.

Relevant External Links for MUC5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC5B: view

No data available for Genatlas for MUC5B Gene

Publications for MUC5B Gene

  1. Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. (PMID: 9804771) Desseyn J.-L. … Laine A. (J. Biol. Chem. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis. (PMID: 25317858) Chung J.H. … Lynch D.A. (Chest 2015) 67
  4. Proteomic analysis of pediatric sinonasal secretions shows increased MUC5B mucin in CRS. (PMID: 25420179) Saieg A. … Preciado D. (Pediatr. Res. 2015) 67
  5. Mucin levels in saliva of adolescents with dental caries. (PMID: 24441930) Gabryel-Porowska H. … Bielawski K. (Med. Sci. Monit. 2014) 67

Products for MUC5B Gene

Sources for MUC5B Gene

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