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MUC5B Gene

protein-coding   GIFtS: 60
GCID: GC11P001244

Mucin 5B, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 5, subtype B, tracheobronchial)
(Previous symbol: MUC5)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucin 5B, Oligomeric Mucus/Gel-Forming1 2     MG12
MUC51 2 3     MUC92
Mucin 5, Subtype B, Tracheobronchial1 2     Cervical Mucin MUC5B2
High Molecular Weight Salivary Mucin MG12 3     mucin-5B2
Sublingual Gland Mucin2 3     Cervical Mucin3
MUC-5B2 3     Mucin-5 Subtype B, Tracheobronchial3

External Ids:    HGNC: 75161   Entrez Gene: 7278972   Ensembl: ENSG000001179837   OMIM: 6007705   UniProtKB: Q9HC843   

Export aliases for MUC5B gene to outside databases

Previous GC identifers: GC11P001736 GC11P001535 GC11P001210 GC11P001211 GC11P001200 GC11P001145 GC11P001037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MUC5B Gene:
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular
components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major
contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus.
This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic
rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H.
pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. (provided by
RefSeq, Jul 2010)

GeneCards Summary for MUC5B Gene:
MUC5B (mucin 5B, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC5B include cervicitis, and biliary papillomatosis. GO annotations related to this gene include extracellular matrix structural constituent.

UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
saliva and cervical mucus

Gene Wiki entry for MUC5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MUC5B gene promoter:
         p53   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MUC5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001244:  view genomic region     (about GC identifiers)

Start:
1,244,295 bp from pter      End:
1,283,406 bp from pter
Size:
39,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84 (See protein sequence)
Recommended Name: Mucin-5B precursor  
Size: 5762 amino acids; 596340 Da
Sequence caution: Sequence=CAA06167.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O00447 O00573 O14985 O15494 O95291 O95451 Q14881 Q7M4S5 Q99552 Q9UE28

Explore the universe of human proteins at neXtProt for MUC5B: NX_Q9HC84

Explore proteomics data for MUC5B at MOPED

Post-translational modifications: 

  • Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first
    Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat
    region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol1
  • Glycosylation2 at Asn145, Asn201, Asn254, Asn401, Asn515, Asn805, Asn929, Asn1276, Asn1292, Trp1340,
                                 Trp1509, Asn1556, Asn1774, Trp1790, Trp2320, Asn2749, Trp2877, Asn3449, Trp3577, Asn4006 (see all 38)
  • Modification sites at PhosphoSitePlus

  • See MUC5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002449.2  
    ENSEMBL proteins: 
     ENSP00000436812   ENSP00000434539   ENSP00000415793  
    Reactome Protein details: Q9HC84

    MUC5B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MUC: Mucins

    Selected InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR006552 VWC_out
     IPR002919 TIL_dom
     IPR025155 WxxW_domain

    Graphical View of Domain Structure for InterPro Entry Q9HC84

    ProtoNet protein and cluster: Q9HC84

    5 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 3 HAT repeats
    Similarity: Contains 3 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 4 VWFD domains


    MUC5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC5B_HUMAN, Q9HC84
    Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
    saliva and cervical mucus
    Induction: Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner

         Genatlas biochemistry entry for MUC5B:
    mucin 5B,belonging to the secreted mucins cluster,expressed in tracheobronchial tissues,submaxillary glands,gall
    bladder and endocervix

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding IPI1718282
         
    MUC5B for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target MUC5B:
    hsa-mir-335-5p (MIRT017724)

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    2 qRT-PCR Assays for microRNAs that regulate MUC5B:
    hsa-miR-149 hsa-miR-3116
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC5B_HUMAN, Q9HC84: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    cytoskeleton2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005796Golgi lumen TAS--

    MUC5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MUC5B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3IL-17 Family Signaling Pathways
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    4NOD-like Receptor Signaling Pathways
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    5Salivary secretion
    Salivary secretion0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MUC5B
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    2 Reactome Pathways for MUC5B
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis


    1 Kegg Pathway  (Kegg details for MUC5B):
        Salivary secretion


    MUC5B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC5B
    Interactions:

        GeneGlobe Interaction Network for MUC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MUC5B (Q9HC843 ENSP000004157934) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1AP047453, ENSP000003591004I2D: score=1 STRING: ENSP00000359100
    AMY1BP047453I2D: score=1 
    AMY1CP047453I2D: score=1 
    HTN1P155153, ENSP000002468964I2D: score=1 STRING: ENSP00000246896
    STATHP028083, ENSP000002468954I2D: score=1 STRING: ENSP00000246895
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MUC5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC5B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MUC5B gene: 
    NM_002458.2  

    Unigene Cluster for MUC5B:

    Mucin 5B, oligomeric mucus/gel-forming
    Hs.523395  [show with all ESTs]
    Unigene Representative Sequence: NM_002458
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525715(uc009yct.2) ENST00000529681 ENST00000531082 ENST00000526859
    ENST00000527802 ENST00000447027(uc001lta.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MUC5B:
    hsa-miR-149 hsa-miR-3116
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MUC5B
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MUC5B
      QuantiFast Probe-based Assays in human, mouse, rat MUC5B

    Additional mRNA sequence: 

    AF086604.1 AF253321.1 AK303892.1 AK310939.1 S80993.1 U63836.1 U78550.1 U78551.1 
    U95031.1 X74370.1 X74954.1 X74955.1 X74956.1 

    11 DOTS entries:

    DT.40195242  DT.97854119  DT.91677252  DT.412176  DT.95314626  DT.91736039  DT.75149513  DT.91694103 
    DT.95314623  DT.100892739  DT.75121497 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MUC5B expression in normal human tissues (normalized intensities)      MUC5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCTGCAG
    MUC5B Expression
    About this image


    MUC5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Mucus-producing Cells Respiratory Bronchioles
     
     Lung (Respiratory System)
             Mucus-producing Cells Respiratory Bronchioles
     
     Ovary (Reproductive System)
             Oviduct
     
     Eye (Sensory Organs)
             Conjunctival Goblet Cells Conjunctival Epithelium
     
     Gall Bladder (Hepatobiliary System)
    MUC5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523395

    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Tissue specificity: Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands
    of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall
    bladder, and pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MUC5B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc5b1 , 5 mucin 5, subtype B, tracheobronchial1, 5 67.89(n)1
    61.56(a)1
      7 (87.29 cM)5
    741801  NM_028801.21  NP_083077.21 
     1418390725 
    chicken
    (Gallus gallus)
    Aves LOC1008599161 mucin-5AC-like 56.2(n)
    51.49(a)
      100859916  XM_003641322.2  XP_003641370.2 
    lizard
    (Anolis carolinensis)
    Reptilia MUC5B6
    mucin 5B, oligomeric mucus/gel-forming
    44(a)
    1 ↔ 1
    1(71905642-71976150)
    zebrafish
    (Danio rerio)
    Actinopterygii muc5f6
    MUC5B (2 of 4)6
    (see all 4)
    mucin 5B, oligomeric mucus/gel-forming
    (see all 4)
    26(a)
    26(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    7(74914272-74920417) ENSDARG00000090771
    Zv9_NA774(476-22601) ENSDARG00000073938


    ENSEMBL Gene Tree for MUC5B (if available)
    TreeFam Gene Tree for MUC5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MUC5B gene
    4 SIMAP similar genes for MUC5B using alignment to 6 protein entries:     MUC5B_HUMAN (see all proteins):
    MG1    MLP    MUC5AC    MUC2

    MUC5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MUC5B
    PGOHUM00000242549


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MUC5B (see all 2208)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128040041,2
    C,F--1182961(+) CTGAGT/GTAAAG 1 -- us2k121Minor allele frequency- G:0.38EA NA NS WA CSA 1041
    rs562676281,2
    C,F--1183070(+) ACAGGT/GGGCAA 1 -- us2k15Minor allele frequency- G:0.01NS 190
    rs1868988081,2
    --1183090(+) GCTCCA/GTTCAC 1 -- us2k10--------
    rs1906550881,2
    --1183095(+) GTTCAC/TGTCGC 1 -- us2k10--------
    rs560314191,2
    C,F--1183134(+) AGAACG/ATTCTC 1 -- us2k16Minor allele frequency- A:0.02NS NA 310
    rs8689021,2
    C,F,A,H--1183170(+) CCATGA/CAACAC 1 -- us2k118Minor allele frequency- C:0.21EA NA NS WA CSA 714
    rs1401385031,2
    --1183237(+) CGGGTC/TTCATG 1 -- us2k10--------
    rs1438713661,2
    --1183261(+) CACACA/GAGTGG 1 -- us2k10--------
    rs1832255561,2
    --1183267(+) AGTGGC/TCCCTC 1 -- us2k10--------
    rs8689031,2
    C,F,A,H--1183352(+) CAGCCT/CCTCCT 1 -- us2k1 trp336Minor allele frequency- C:0.47EA NS NA MN WA CSA 3871

    HapMap Linkage Disequilibrium report for MUC5B (1244295 - 1283406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MUC5B (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1522213CNV Deletion17803354
    esv2743878CNV Deletion23290073
    esv2743906CNV Deletion23290073
    esv2669189CNV Deletion23128226
    dgv967n71CNV Loss21882294
    nsv469923CNV Loss18288195
    nsv467637CNV Loss19166990
    dgv965n71CNV Loss21882294
    dgv968n71CNV Loss21882294
    nsv896644CNV Loss21882294

    Human Gene Mutation Database (HGMD): MUC5B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600770   
    OMIM disorders: 178500  
    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
  • Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath,
    radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on
    biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury
    with subsequent scarring and end-stage lung disease. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with
    familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression
    in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741)

  • Selected diseases for MUC5B (see all 33):    About MalaCards
    cervicitis    biliary papillomatosis    sinusitis    diffuse panbronchiolitis
    idiopathic pulmonary fibrosis    pulmonary fibrosis, familial    pseudomyxoma peritonei    dry eye syndrome
    pulmonary fibrosis    common cold    otitis media    atrophic gastritis
    dental caries    peptic ulcer    bronchitis    gastritis
    stomach cancer    barrett's esophagus    bronchiolitis    sarcoidosis

    12 diseases from the University of Copenhagen DISEASES database for MUC5B:
    Carcinoma     Asthma     Chronic obstructive pulmonary disease     Adenoma
    Otitis media     Cystic fibrosis     Pseudomyxoma peritonei     Cholangiocarcinoma
    Gastritis     Bronchitis     Biliary papillomatosis     Sinusitis

    MUC5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): MUC5B
    Human Genome Epidemiology (HuGE) Navigator: MUC5B (7 documents)

    Export disorders for MUC5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MUC5B gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with MUC5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. (PubMed id 9804771)1, 2, 3 Desseyn J.-L.... Laine A. (J. Biol. Chem. 1998)
    2. A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. (PubMed id 21506748)1, 2 Zhang Y.... Kaminski N. (N. Engl. J. Med. 2011)
    3. A common MUC5B promoter polymorphism and pulmonary fibrosis. (PubMed id 21506741)1, 2 Seibold M.A.... Schwartz D.A. (N. Engl. J. Med. 2011)
    4. Mucin gene polymorphisms in otitis media patients. (PubMed id 19718741)1, 4 Ubell M.L....Kerschner J.E. (Laryngoscope 2010)
    5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    6. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. (PubMed id 19191526)1, 4 Ahn E.K....Leem S.H. (DNA Cell Biol. 2009)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    10. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1, 4 Lee J.K....Jo I. (J. Hum. Genet. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 727897 HGNC: 7516 Ensembl:ENSG00000117983 euGenes: HUgn727897 ECgene: MUC5B Kegg: 727897
    H-InvDB: MUC5B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MUC5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC5B Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MUC5B gene:
    Search GeneIP for patents involving MUC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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