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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC5B Gene

protein-coding   GIFtS: 59
GCID: GC11P001244

Mucin 5B, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 5, subtype B, tracheobronchial)
(Previous symbol: MUC5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mucin 5B, Oligomeric Mucus/Gel-Forming1 2     MG12
MUC51 2 3     MUC92
Mucin 5, Subtype B, Tracheobronchial1 2     Cervical Mucin MUC5B2
High Molecular Weight Salivary Mucin MG12 3     mucin-5B2
Sublingual Gland Mucin2 3     Cervical Mucin3
MUC-5B2 3     Mucin-5 Subtype B, Tracheobronchial3

External Ids:    HGNC: 75161   Entrez Gene: 7278972   Ensembl: ENSG000001179837   OMIM: 6007705   UniProtKB: Q9HC843   

Export aliases for MUC5B gene to outside databases

Previous GC identifers: GC11P001736 GC11P001535 GC11P001210 GC11P001211 GC11P001200 GC11P001145 GC11P001037


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MUC5B Gene:
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular
components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major
contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus.
This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic
rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H.
pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. (provided by
RefSeq, Jul 2010)

GeneCards Summary for MUC5B Gene: 
MUC5B (mucin 5B, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC5B include cervicitis, and sinusitis, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Mucin expression in CF via IL-6, IL-17 signaling pathways. GO annotations related to this gene include extracellular matrix structural constituent and protein binding. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
saliva and cervical mucus

Gene Wiki entry for MUC5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC5B gene promoter:
         p53   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MUC5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001244:  view genomic region     (about GC identifiers)

Start:
1,244,295 bp from pter      End:
1,283,406 bp from pter
Size:
39,112 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84 (See protein sequence)
Recommended Name: Mucin-5B precursor  
Size: 5762 amino acids; 596340 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAA06167.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O00447 O00573 O14985 O15494 O95291 O95451 Q14881 Q7M4S5 Q99552 Q9UE28

Explore the universe of human proteins at neXtProt for MUC5B: NX_Q9HC84

Explore proteomics data for MUC5B at MOPED 

Post-translational modifications:

  • UniProtKB: Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first
    Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat
    region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HC84

  • MUC5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MUC5B Protein Expression
    REFSEQ proteins: NP_002449.2  
    ENSEMBL proteins: 
     ENSP00000436812   ENSP00000434539   ENSP00000415793  
    Reactome Protein details: Q9HC84
    Human Recombinant Protein Products for MUC5B: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MUC5B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005796Golgi lumen TAS--

    MUC5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    5/7 InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR006552 VWC_out
     IPR002919 TIL_dom
     IPR025155 WxxW_domain

    Graphical View of Domain Structure for InterPro Entry Q9HC84

    ProtoNet protein and cluster: Q9HC84

    5 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 3 HAT repeats
    Similarity: Contains 3 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 4 VWFD domains


    MUC5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC5B_HUMAN, Q9HC84
    Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
    saliva and cervical mucus
    Induction: Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner

         Genatlas biochemistry entry for MUC5B:
    mucin 5B,belonging to the secreted mucins cluster,expressed in tracheobronchial tissues,submaxillary glands,gall
    bladder and endocervix

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS--
    GO:0005515protein binding IPI1718282
         
    MUC5B for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MUC5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    3Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    4Gastric acid secretion
    Salivary secretion0.34
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MUC5B
        Selected targets of CREB1


    2 GeneGo (Thomson Reuters) Pathways for MUC5B
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    4        Reactome Pathways for MUC5B
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis


    1         Kegg Pathway  (Kegg details for MUC5B):
        Salivary secretion


    MUC5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for MUC5B (Q9HC843 ENSP000004157934) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1AP047453, ENSP000003591004I2D: score=1 STRING: ENSP00000359100
    AMY1BP047453I2D: score=1 
    AMY1CP047453I2D: score=1 
    HTN1P155153, ENSP000002468964I2D: score=1 STRING: ENSP00000246896
    STATHP028083, ENSP000002468954I2D: score=1 STRING: ENSP00000246895
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MUC5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC5B

    Search CenterWatch for drugs/clinical trials and news about MUC5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MUC5B gene: 
    NM_002458.2  

    Unigene Cluster for MUC5B:

    Mucin 5B, oligomeric mucus/gel-forming
    Hs.523395  [show with all ESTs]
    Unigene Representative Sequence: NM_002458
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525715(uc009yct.2) ENST00000529681 ENST00000531082 ENST00000526859
    ENST00000527802 ENST00000447027(uc001lta.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MUC5B:
    hsa-miR-149 hsa-miR-3116
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: MUC5B (NM_002458)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC5B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC5B
    Primer
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    Additional mRNA sequence: 

    AF086604.1 AF253321.1 AK303892.1 AK310939.1 S80993.1 U63836.1 U78550.1 U78551.1 
    U95031.1 X74370.1 X74954.1 X74955.1 X74956.1 

    11 DOTS entries:

    DT.40195242  DT.97854119  DT.91677252  DT.412176  DT.95314626  DT.91736039  DT.75149513  DT.91694103 
    DT.95314623  DT.100892739  DT.75121497 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC5B expression in normal human tissues (normalized intensities)      MUC5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCTGCAG
    MUC5B Expression
    About this image


    MUC5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Mucus-producing Cells Respiratory Bronchioles
             bronchus ; respiratory epithelial cells   
             trachea   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             colonic mucosal (ibs)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             nasopharynx ; respiratory epithelial cells   
             bronchial epithelia   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, post-menopause ; glandular cells   

    See MUC5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC5B

    SOURCE GeneReport for Unigene cluster: Hs.523395

    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Tissue specificity: Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands
    of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall
    bladder, and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MUC5B gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc5b5 mucin 5, subtype B, tracheobronchial   --   7 (87.29 cM) 141839072 
    chicken
    (Gallus gallus)
    Aves LOC1008599161 mucin-5AC-like 55.67(n)
    51.59(a)
      100859916  XM_003641322.1  XP_003641370.1 
    lizard
    (Anolis carolinensis)
    Reptilia MUC46
    Uncharacterized protein
    7(a)
    possible ortholog
    GL343433.1(112703-138343)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    (see all 7)
    --
    8(a)
    21(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    1(45594383-45602312)
    8(2360706-2381987)
    fruit fly
    (Drosophila melanogaster)
    Insecta Muc68D6
    Sgs16
    (see all 4)
    Salivary gland secretion 1
    (see all 4)
    9(a)
    17(a)
    (see all 4)
    possible ortholog
    many ↔ many
    (see all 4)
    3L(11760399-11765257)
    2L(4937409-4941424)
    worm
    (Caenorhabditis elegans)
    Secernentea W05F2.76
    Protein W05F2.7
    8(a)
    possible ortholog
    I(3352463-3359433)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MUC16
    GPI-anchored cell surface glycoprotein (flocculin)...
    16(a)
    1 → many
    IX(389572-393675)


    ENSEMBL Gene Tree for MUC5B (if available)
    TreeFam Gene Tree for MUC5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC5B gene
    MUC5AC2  ZAN2  TECTA2  OTOG2  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    4 SIMAP similar genes for MUC5B using alignment to 6 protein entries:     MUC5B_HUMAN (see all proteins):
    MG1    MUC5AC    MLP    MUC2

    MUC5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MUC5B
    PGOHUM00000242549


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2208 SNPs in MUC5B are shown (see all 2208)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0636224
    ----see VAR_0636222 M T mis40--------
    VAR_0636264
    ----see VAR_0636262 T M mis40--------
    VAR_0636234
    ----see VAR_0636232 F S mis40--------
    VAR_0595414
    ----see VAR_0595412 T M mis40--------
    VAR_0636194
    ----see VAR_0636192 A T mis40--------
    rs128040041,2
    C,F--1182961(+) CTGAGT/GTAAAG 1 -- us2k121Minor allele frequency- G:0.38EA NA NS WA CSA 1041
    rs562676281,2
    C,F--1183070(+) ACAGGT/GGGCAA 1 -- us2k15Minor allele frequency- G:0.01NS 190
    rs1868988081,2
    --1183090(+) GCTCCA/GTTCAC 1 -- us2k10--------
    rs1906550881,2
    --1183095(+) GTTCAC/TGTCGC 1 -- us2k10--------
    rs560314191,2
    C,F--1183134(+) AGAACG/ATTCTC 1 -- us2k16Minor allele frequency- A:0.02NS NA 310

    HapMap Linkage Disequilibrium report for MUC5B (1244295 - 1283406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for MUC5B (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1522213CNV Deletion17803354
    esv2743878CNV Deletion23290073
    esv2743906CNV Deletion23290073
    esv2669189CNV Deletion23128226
    dgv967n71CNV Loss21882294
    nsv469923CNV Loss18288195
    nsv467637CNV Loss19166990
    dgv965n71CNV Loss21882294
    dgv968n71CNV Loss21882294
    nsv896644CNV Loss21882294


    Human Gene Mutation Database (HGMD): MUC5B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MUC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600770    OMIM disorders: --

    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
  • Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath,
    radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on
    biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism
    in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis,
    suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary
    fibrosis (PubMed:21506741)

  • 20/32 diseases for MUC5B (see all 32):    About MalaCards
    cervicitis    sinusitis    biliary papillomatosis    diffuse panbronchiolitis
    ampulla of vater carcinoma    chronic obstructive pulmonary disease    pseudomyxoma peritonei    pulmonary fibrosis, familial
    dry eye syndrome    atrophic gastritis    common cold    otitis media
    dental caries    peptic ulcer    bronchitis    gastritis
    pulmonary fibrosis    cystic fibrosis    stomach cancer    barrett's esophagus

    12 diseases from the University of Copenhagen DISEASES database for MUC5B:
    Carcinoma     Asthma     Chronic obstructive pulmonary disease     Adenoma
    Otitis media     Cystic fibrosis     Pseudomyxoma peritonei     Cholangiocarcinoma
    Gastritis     Bronchitis     Biliary papillomatosis     Sinusitis

    MUC5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MUC5B
    Human Genome Epidemiology (HuGE) Navigator: MUC5B (7 documents)

    Export disorders for MUC5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC5B gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with MUC5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. (PubMed id 9804771)1, 2, 3 Desseyn J.-L.... Laine A. (1998)
    2. A variant in the promoter of MUC5B and idiopathic pul monary fibrosis. (PubMed id 21506748)1, 2 Zhang Y....Kaminski N. (2011)
    3. A common MUC5B promoter polymorphism and pulmonary fi brosis. (PubMed id 21506741)1, 2 Seibold M.A....Schwartz D.A. (2011)
    4. Mucin gene polymorphisms in otitis media patients. (PubMed id 19718741)1, 4 Ubell M.L....Kerschner J.E. (2010)
    5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    6. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. (PubMed id 19191526)1, 4 Ahn E.K....Leem S.H. (2009)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    9. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    10. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1, 4 Lee J.K....Jo I. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 727897 HGNC: 7516 Ensembl:ENSG00000117983 euGenes: HUgn727897 ECgene: MUC5B Kegg: 727897
    H-InvDB: MUC5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC5B Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC5B gene:
    Search GeneIP for patents involving MUC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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