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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC5B Gene

protein-coding   GIFtS: 59
GCID: GC11P001244

mucin 5B, oligomeric mucus/gel-forming

(Previous names: mucin 5, subtype B, tracheobronchial )
(Previous symbol: MUC5)
 Explore 36 diseases affiliated with
MUC5B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MUC5B    

Aliases
for MUC5B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mucin 5B, Oligomeric Mucus/Gel-Forming1 2     MUC-5B2 3
MUC51 2 3     MUC92
MG11 2     Cervical Mucin MUC5B2
Mucin 5, Subtype B, Tracheobronchial1 2     Mucin-5B1
High Molecular Weight Salivary Mucin MG12 3     Cervical Mucin3
Sublingual Gland Mucin2 3     Mucin-5 Subtype B, Tracheobronchial3

External Ids:    HGNC: 75161   Entrez Gene: 7278972   Ensembl: ENSG000001179837   OMIM: 6007705   UniProtKB: Q9HC843   

Export aliases for MUC5B gene to outside databases

Previous GC identifers: GC11P001736 GC11P001535 GC11P001210 GC11P001211 GC11P001200 GC11P001145 GC11P001037


Summaries
for MUC5B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MUC5B:
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of
mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the
lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been
found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with
nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be
involved in the pathogenesis of these diseases. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
saliva and cervical mucus

Gene Wiki entry for MUC5B


Genomic Views
for MUC5B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC5B gene promoter:
         p53   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MUC5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001244:  view genomic region     (about GC identifiers)

Start:
 1,244,295 bp from pter      End:
 1,283,406 bp from pter
Size:
 39,112 bases      Orientation:
 plus strand

Proteins
for MUC5B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84 (See protein sequence)
Recommended Name: Mucin-5B precursor  
Size: 5762 amino acids; 596340 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAA06167.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O00447 O00573 O14985 O15494 O95291 O95451 Q14881 Q7M4S5 Q99552 Q9UE28

Explore the universe of human proteins at neXtProt for MUC5B: NX_Q9HC84

Post-translational modifications:

  • Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp
    • residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is
    about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HC84

    • MUC5B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002449.2  
    ENSEMBL proteins: 
     ENSP00000436812   ENSP00000434539   ENSP00000415793  
    Reactome Protein details: Q9HC84
    Human Recombinant Protein Products: 
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    Uscn Proteins for MUC5B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005796Golgi lumen TAS--


    MUC5B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MUC5B

    Protein Domains /
    Families
    for MUC5B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MUC5B for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR006552 VWC_out
     IPR002919 TIL_dom
     IPR006207 Cys_knot_C
     IPR025155 WxxW_domain

    Graphical View of Domain Structure for InterPro Entry Q9HC84

    ProtoNet protein and cluster: Q9HC84

    5 Blocks protein families:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 3 HAT repeats
    Similarity: Contains 3 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 4 VWFD domains


    Function
    for MUC5B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Function: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole
    saliva and cervical mucus
    Induction: Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner

         Genatlas biochemistry entry for MUC5B:
    mucin 5B,belonging to the secreted mucins cluster,expressed in tracheobronchial tissues,submaxillary glands,gall
    bladder and endocervix

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS--
    GO:0005515protein binding IPI1718282


    MUC5B for ontologies           About GeneDecksing



    Pathways & Interactions
    for MUC5B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    		Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein1.00
    		Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein1.00
    		Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein1.00
    		Termination of O-glycan biosynthesis0.69
    		Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein1.00
    		O-linked glycosylation of mucins0.28
    2Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    		Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    3Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    4Selected targets of CREB1
    		Selected targets of CREB11.00
    5Gastric acid secretion
    		Salivary secretion0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MUC5B
        Selected targets of CREB1


    2 GeneGo (Thomson Reuters) Pathways for MUC5B
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    5/8        Reactome Pathways for MUC5B (see all 8)
        Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein


    1         Kegg Pathway  (Kegg details for MUC5B):
        Salivary secretion


    MUC5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for MUC5B (Q9HC843 ENSP000004157934) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1AP047453, ENSP000003591004I2D: score=1 STRING: ENSP00000359100
    AMY1BP047453I2D: score=1 
    AMY1CP047453I2D: score=1 
    HTN1P155153, ENSP000002468964I2D: score=1 STRING: ENSP00000246896
    STATHP028083, ENSP000002468954I2D: score=1 STRING: ENSP00000246895
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MUC5B for ontologies           About GeneDecksing



    Drugs & Compounds
    for MUC5B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC5B
    Search CenterWatch for drugs/clinical trials and news about MUC5B 

    Transcripts
    for MUC5B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MUC5B gene: 
    NM_002458.2  

    Unigene Cluster for MUC5B:

    Mucin 5B, oligomeric mucus/gel-forming
    Hs.523395  [show with all ESTs]
    Unigene Representative Sequence: NM_002458
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525715(uc009yct.2) ENST00000529681 ENST00000531082 ENST00000526859
    ENST00000527802 ENST00000447027(uc001lta.3)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MUC5B:
    hsa-miR-149 hsa-miR-3116
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: MUC5B
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MUC5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MUC5B

    Additional cDNA sequence: 

    AF086604.1 AF253321.1 AK303892.1 AK310939.1 S80993.1 U63836.1 U78550.1 U78551.1 
    U95031.1 X74370.1 X74954.1 X74955.1 X74956.1 

    10 DOTS entries:

    DT.40195242  DT.97854119  DT.91677252  DT.412176  DT.95314626  DT.91736039  DT.75149513  DT.91694103 
    DT.95314623  DT.100892739 

    GeneLoc Exon Structure


    Expression
    for MUC5B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCTGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MUC5B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesMucus-producing CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MUC5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC5B

    SOURCE GeneReport for Unigene cluster: Hs.523395

    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
    Tissue specificity: Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of
    airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder,
    and pancreas

        SABiosciences Custom PCR Arrays for MUC5B
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    In Situ
    Assay Products:     
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    Orthologs
    for MUC5B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MUC5B gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008599161 mucin-5AC-like 55.67(n)
    51.59(a)    		   100859916  XM_003641322.1  XP_003641370.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 45(a)
    38(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 1(71906025-71976150)
    1(72015518-72085064)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01073389.16
    si:ch73-343m12.16
    (see all 3)    		 si:ch73-343m12.1
    (see all 3)    		 35(a)
    20(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 Zv9_NA551(27558-29779)
    7(74859528-74903390)


    ENSEMBL Gene Tree for MUC5B (if available)
    TreeFam Gene Tree for MUC5B (if available) 

    Paralogs
    for MUC5B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC5B gene
    MUC5AC2  TECTA2  OTOG2  MUC22  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    5 SIMAP similar genes for MUC5B using alignment to 6 protein entries:     MUC5B_HUMAN (see all proteins):
    MG1    MUC5AC    MLP    MUC2    MUC19

    MUC5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MUC5B
    PGOHUM00000242549


    Genomic Variants
    for MUC5B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1264 NCBI SNPs in MUC5B are shown (see all 1264)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs128040041,2
    		C,F,--1242299(+) CTGAGT/GTAAAG 1 -- us2k121Minor allele frequency- G:0.38EA NA NS WA CSA 1041
    rs562676281,2
    		C,--1242408(+) ACAGGT/GGGCAA 1 -- us2k15Minor allele frequency- G:0.01NS 190
    rs1868988081,2
    		--1242428(+) GCTCCA/GTTCAC 1 -- us2k10--------
    rs1906550881,2
    		--1242433(+) GTTCAC/TGTCGC 1 -- us2k10--------
    rs560314191,2
    		C,F,--1242472(+) AGAACG/ATTCTC 1 -- us2k16Minor allele frequency- A:0.02NS NA 310
    rs8689021,2
    		C,F,A,H,--1242508(+) CCATGA/CAACAC 1 -- us2k118Minor allele frequency- C:0.21EA NA NS WA CSA 714
    rs1401385031,2
    		--1242575(+) CGGGTC/TTCATG 1 -- us2k10--------
    rs1438713661,2
    		--1242599(+) CACACA/GAGTGG 1 -- us2k10--------
    rs1832255561,2
    		--1242605(+) AGTGGC/TCCCTC 1 -- us2k10--------
    rs8689031,2
    		C,F,A,H,--1242690(+) CAGCCT/CCTCCT 1 -- us2k1 trp336Minor allele frequency- C:0.47EA NS NA MN WA CSA 3871

    HapMap Linkage Disequilibrium report for MUC5B (1244295 - 1283406 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for MUC5B
         6 CNVs: 3831 23399 30532 29887 71224 29888
    Human Gene Mutation Database (HGMD): MUC5B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MUC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC5B

    Disorders / Diseases
    for MUC5B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MUC5B for disorders           About GeneDecksing

    OMIM gene information: 600770    OMIM disorders: --

    UniProtKB/Swiss-Prot: MUC5B_HUMAN, Q9HC84
  • Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary
    • fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary
    infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with
    subsequent scarring and endstage lung disease. Note=A common polymorphism in the promoter of MUC5B is associated with
    familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in
    the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741)

    20/36 diseases for MUC5B (see all 36):    About MalaCards
    chronic obstructive pulmonary disease    cervicitis    pulmonary disease    sinusitis
    polyposis    pseudomyxoma peritonei    otitis media    dry eye syndrome
    ampulla of vater carcinoma    common cold    copd    dental caries
    diffuse panbronchiolitis    biliary papillomatosis    panbronchiolitis    atrophic gastritis
    barrett's esophagus    cystic fibrosis lung disease    peptic ulcer    cystic fibrosis

    13 diseases from the University of Copenhagen DISEASES database for MUC5B:
    Carcinoma     Asthma     Chronic obstructive pulmonary disease     Adenoma
    Otitis media     Cystic fibrosis     Pseudomyxoma peritonei     Cholangiocarcinoma
    Dry eye syndrome     Gastritis     Bronchitis     Biliary papillomatosis
    Sinusitis
    Genetic Association Database (GAD): MUC5B
    Human Genome Epidemiology (HuGE) Navigator: MUC5B (7 documents)

    Export disorders for MUC5B gene to outside databases

    Publications
    for MUC5B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC5B gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with MUC5B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. (PubMed id 9804771)1, 2, 3 Desseyn J.-L.... Laine A. (1998)
    2. A variant in the promoter of MUC5B and idiopathic pul monary fibrosis. (PubMed id 21506748)1, 2 Zhang Y....Kaminski N. (2011)
    3. A common MUC5B promoter polymorphism and pulmonary fi brosis. (PubMed id 21506741)1, 2 Seibold M.A....Schwartz D.A. (2011)
    4. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    5. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. (PubMed id 11713095)1, 2 Chen Y.... Wu R. (2001)
    6. Polymorphism of human mucin genes in chest disease: possible significance of MUC2. (PubMed id 11062147)1, 4 Vinall L.E....Swallow D.M. (2000)
    7. The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. (PubMed id 9790959)1, 2 Offner G.D.... Troxler R.F. (1998)
    8. Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family. (PubMed id 9013550)1, 2 Desseyn J.-L....Laine A. (1997)
    9. Molecular cloning of a major human gall bladder mucin: complete C- terminal sequence and genomic organization of MUC5B. (PubMed id 9164870)1, 2 Keates A.C.... Offner G.D. (1997)
    10. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. (PubMed id 9147051)1, 2 Nielsen P.A.... Clausen H. (1997)

    External Searches for MUC5B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing MUC5B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 727897 HGNC: 7516 Ensembl:ENSG00000117983 euGenes: HUgn727897 ECgene: MUC5B Kegg: 727897
    H-InvDB: MUC5B

    Other Databases showing MUC5B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MUC5B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC5B Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    Intellectual Property
    for MUC5B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MUC5B gene:
    Search GeneIP for patents involving MUC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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