Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MUC5AC Gene

protein-coding   GIFtS: 57
GCID: GC11P001151

Mucin 5AC, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 5, subtypes A and C, tracheobronchial/gastric)
  See MUC5AC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mucin 5AC, Oligomeric Mucus/Gel-Forming1 2     Tracheobronchial Mucin2 3
MUC52 3 5     TBM2 3
Mucin 5, Subtypes A And C, Tracheobronchial/Gastric1 2     leB2
Gastric Mucin2 3     Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene2
Lewis B Blood Group Antigen2 3     LeB3
Major Airway Glycoprotein2 3     MUC-5AC3
Mucin-5 Subtype AC, Tracheobronchial2 3     

External Ids:    HGNC: 75151   Entrez Gene: 45862   Ensembl: ENSG000002151827   OMIM: 1583735   UniProtKB: P980883   

Export aliases for MUC5AC gene to outside databases

Previous GC identifers: GC11U990089 GC11P001169 GC11P000972


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MUC5AC Gene:
MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC5AC include anal canal adenocarcinoma, and ampulla of vater carcinoma. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is ZAN.

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from
infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by
the mucocilary system

Gene Wiki entry for MUC5AC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MUC5AC gene promoter:
         Sp1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC5AC promoter sequence
   Search Chromatin IP Primers for MUC5AC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC5AC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC5AC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5AC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001151:  view genomic region     (about GC identifiers)

Start:
1,142,474 bp from pter      End:
1,222,364 bp from pter
Size:
79,891 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088 (See protein sequence)
Recommended Name: Mucin-5AC precursor  
Size: 5030 amino acids; 526608 Da
Subunit: Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric
metaplasia of the duodenum (GMD)
Sequence caution: Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Sequence=AAC15950.1; Type=Frameshift;
Positions=24, 44, 671, 683; Sequence=CAA88307.1; Type=Frameshift; Positions=5024; Sequence=CAH56330.1;
Type=Frameshift; Positions=4616;
Secondary accessions: O60460 O76065 Q13792 Q14425 Q658Q1 Q7M4S5 Q8N4M9 Q8WWQ3 Q8WWQ4 Q8WWQ5

Explore the universe of human proteins at neXtProt for MUC5AC: NX_P98088

Explore proteomics data for MUC5AC at MOPED

Post-translational modifications: 

  • C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich
    subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum
    during biosynthesis1
  • Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine
    protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a
    reactive group which could link the protein to a primary amide1
  • Glycosylation2 at Asn205, Asn258, Asn415, Asn524, Asn1308, Trp1389, Trp1584, Trp1749, Trp1957, Trp2122,
                                 Trp2652, Trp2950, Asn3198, Trp3383, Trp4009, Asn4245, Asn4318, Asn4433, Asn4469, Asn4612 (see all 26)
  • Modification sites at PhosphoSitePlus

  • See MUC5AC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000435591   ENSP00000348519  
    Reactome Protein details: P98088

    MUC5AC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MUC5AC
    GenScript Custom Purified and Recombinant Proteins Services for MUC5AC
    Novus Biologicals MUC5AC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MUC5AC

     
    Search eBioscience for Proteins for MUC5AC 

     
    antibodies-online proteins for MUC5AC (14 products) 

     
    antibodies-online peptides for MUC5AC

    MUC5AC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MUC5AC
    OriGene Custom Antibody Services for MUC5AC
    Novus Biologicals MUC5AC Antibodies
    Abcam antibodies for MUC5AC
    Cloud-Clone Corp. Antibodies for MUC5AC
    ThermoFisher Antibody for MUC5AC
    antibodies-online antibodies for MUC5AC (103 products) 

    MUC5AC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MUC5AC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MUC5AC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MUC5AC
    Cloud-Clone Corp. CLIAs for MUC5AC
    Search eBioscience for ELISAs for MUC5AC 
    antibodies-online kits for MUC5AC (38 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MUC: Mucins

    Selected InterPro protein domains (see all 6):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR002919 TIL_dom
     IPR025155 WxxW_domain
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry P98088

    ProtoNet protein and cluster: P98088

    4 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot


    UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
    Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 2 VWFC domains
    Similarity: Contains 4 VWFD domains


    Find genes that share domains with MUC5AC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC5A_HUMAN, P98088
    Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from
    infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by
    the mucocilary system

         Genatlas biochemistry entry for MUC5AC:
    mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin
    cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in
    colorectal neoplasia),expressed in epithelial ovarian cancer

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS7513696
         
    Find genes that share ontologies with MUC5AC           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MUC5AC:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Muc5ac):
     digestive/alimentary  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with MUC5AC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Muc5actm1.1Tigm for MUC5AC

       genOway: Develop your customized and physiologically relevant rodent model for MUC5AC

    miRNA
    Products:
        
    miRTarBase miRNAs that target MUC5AC:
    hsa-mir-335-5p (MIRT019024)

    Block miRNA regulation of human, mouse, rat MUC5AC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MUC5AC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MUC5AC
    Predesigned siRNA for gene silencing in human, mouse, rat MUC5AC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MUC5AC

    Clone
    Products:
         
    OriGene clones in human, mouse for MUC5AC
    OriGene ORF clones in mouse, rat for MUC5AC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MUC5AC (XM_003119481)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC5AC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC5AC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MUC5AC
    Browse ESI BIO Cell Lines and PureStem Progenitors for MUC5AC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MUC5A_HUMAN, P98088: Secreted

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005796Golgi lumen TAS--
    GO:0043205fibril IDA14749330
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with MUC5AC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MUC5AC About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3IL-17 Family Signaling Pathways
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    4NOD-like Receptor Signaling Pathways
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    5Selected targets of CREB1
    Selected targets of CREB1


    Find genes that share SuperPaths with MUC5AC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MUC5AC
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    2 Reactome Pathways for MUC5AC
        O-linked glycosylation of mucins
    Termination of O-glycan biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MUC5AC
    Interactions:

        GeneGlobe Interaction Network for MUC5AC

    1 Interacting protein for MUC5AC (P980883) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043206extracellular fibril organization IDA10611155
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with MUC5AC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MUC5AC (MUC5A)

    Selected Novoseek inferred chemical compound relationships for MUC5AC gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 54.8 2 12972643 (1), 15864435 (1)
    niflumic acid 49.2 6 17426222 (2), 17622767 (1), 15696080 (1), 16465045 (1)
    threonine 39.8 3 10410928 (1), 12386453 (1), 9618923 (1)
    serine 32.7 5 20216230 (1), 10330040 (1), 12386453 (1), 9618923 (1) (see all 5)
    pd 98,059 31.1 5 16009452 (1), 12391274 (1), 16773182 (1), 16377262 (1)
    proline 29.6 1 8207007 (1)
    carbohydrates 28.9 3 10697417 (1), 11102566 (1), 11425189 (1)
    periodate 28.3 2 11425189 (1)
    mnng 27.7 1 17066439 (1)
    trifluoromethanesulfonic acid 24.7 3 8699025 (1), 1310044 (1)



    Find genes that share compounds with MUC5AC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MUC5AC gene: 
    NM_017511.1  

    Unigene Clusters for MUC5AC:

    Mucin 5AC, oligomeric mucus/gel-forming
    Hs.534332  [show with all ESTs], Hs.558950  [show with all ESTs]
    Unigene Representative Sequences: AJ001402, X81649
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534821(uc021qbr.1) ENST00000358378(uc001lsz.3 uc009ycs.2)
    ENST00000356191
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MUC5AC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MUC5AC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MUC5AC
    Predesigned siRNA for gene silencing in human, mouse, rat MUC5AC
    Clone
    Products:
         
    OriGene clones in human, mouse for MUC5AC
    OriGene ORF clones in mouse, rat for MUC5AC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MUC5AC (XM_003119481)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MUC5AC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC5AC
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MUC5AC
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MUC5AC
      QuantiTect SYBR Green Assays in human, mouse, rat MUC5AC
      QuantiFast Probe-based Assays in human, mouse, rat MUC5AC

    Additional mRNA sequence: 

    X81649.1 Z34280.1 Z34281.1 Z34282.1 

    6 DOTS entries:

    DT.209839  DT.91804067  DT.95323046  DT.75121497  DT.95264442  DT.91804068 

    Selected AceView cDNA sequences (see all 65):

    Z48314 AJ001402 AI924115 AI828184 AI677639 BM854880 AW298301 BI762047 
    BM782247 BV178294 BM820970 BC033831 BM855872 AI921630 BV204711 BM769723 
    BI761970 BV178834 CA433820 BV174347 BV174348 BM784694 AI925608 AL833060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MUC5AC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTTACA
    MUC5AC Expression
    About this image


    MUC5AC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Mucus-producing Cells Trachea
             Mature airway epithelial cells
     
     Epithelial Cells
             Mucus-producing Cells Respiratory Bronchioles
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    MUC5AC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MUC5AC Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.534332 Hs.558950

    UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
    Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia.
    Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal
    duodenum

        Custom PCR Arrays for MUC5AC
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MUC5AC
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MUC5AC
    QuantiTect SYBR Green Assays in human, mouse, rat MUC5AC
    QuantiFast Probe-based Assays in human, mouse, rat MUC5AC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MUC5AC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc5ac1 , 5 mucin 5, subtypes A and C, tracheobronchial/gastric1, 5 74.33(n)1
    70.46(a)1
      7 (87.23 cM)5
    178331  NM_010844.11  NP_034974.11 
     1417889725 
    chicken
    (Gallus gallus)
    Aves --
    --
    Mucin-5B
    8(a)
    12(a)
    1 ↔ many
    1 ↔ many
    5(14079795-14176709) ENSGALG00000006740
    5(14243984-14284324) ENSGALG00000006717
    lizard
    (Anolis carolinensis)
    Reptilia MUC5AC6
    mucin 5AC, oligomeric mucus/gel-forming
    12(a)
    1 ↔ 1
    1(72199509-72262441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004939371 mucin-5AC-like 55.7(n)
    52.15(a)
      100493937  XM_002936038.2  XP_002936084.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001488041 mucin-2-like 49.24(n)
    41.71(a)
      100148804  XM_005162979.1  XP_005163036.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hml6
    Hemolectin
    4(a)
    1 → many
    3L(13839154-13853101)


    ENSEMBL Gene Tree for MUC5AC (if available)
    TreeFam Gene Tree for MUC5AC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MUC5AC gene
    ZAN2  TECTA2  MUC22  OTOG2  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    6 SIMAP similar genes for MUC5AC using alignment to 22 protein entries:     MUC5A_HUMAN (see all proteins):
    MG1    MLP    MUC5B    MUC2    OTOG    MUC19

    Find genes that share paralogs with MUC5AC           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MUC5AC
    PGOHUM00000258306


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MUC5AC (see all 57)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs287374161,2
    C,F--979361(+) CGGCAC/TACAGG 2 H syn114Minor allele frequency- T:0.38NS NA WA CSA EA 542
    rs1890369511,2
    C--980851(+) CTGTGC/TGGGGC 1 -- int10--------
    rs285507251,2
    C--980861(+) CTGTGC/TGGGGC 1 -- int10--------
    rs2013021501,2
    --980862(+) TGTGT-/GGGG  
      CTGTGC
    GGGGC
    1 -- int10--------
    rs1456667251,2
    C--980871(+) CTGTGC/TGGGGC 1 -- int10--------
    rs1923366071,2
    --980881(+) CTGTGC/TGGGGC 1 -- int10--------
    rs286912311,2
    C,F--985738(+) CCCTGC/TGCAGA 2 C syn120Minor allele frequency- T:0.14NA NS WA CSA EA EU 1117
    rs289727531,2
    F--986241(+) TGTCCC/TGGGCC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs289729601,2
    C,F--986273(+) TGTCCC/TGGGCC 1 -- int12Minor allele frequency- T:0.50NA WA 4
    rs563157181,2
    C--986295(+) GCTGAG/TGCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MUC5AC (1142474 - 1222364 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MUC5AC: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MUC5AC
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC5AC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 158373    OMIM disorders: --

    Selected diseases for MUC5AC (see all 22):    
    About MalaCards
    anal canal adenocarcinoma    ampulla of vater carcinoma    pancreatic mucinous cystadenoma    congenital pulmonary airway malformation
    biliary papillomatosis    ampulla of vater adenocarcinoma    ovarian mucinous adenocarcinoma    hidradenocarcinoma
    diverticulitis    limbal stem cell deficiency    atopic keratoconjunctivitis    corneal ulcer
    villous adenoma    cholangiocarcinoma    primary angle-closure glaucoma    pseudomyxoma peritonei
    sweat gland carcinoma    epstein-barr virus-associated gastric carcinoma    status asthmaticus    cystic fibrosis


    Find genes that share disorders with MUC5AC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MUC5AC gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metaplasia 81.1 55 10070955 (4), 10190312 (3), 17090193 (2), 14631367 (2) (see all 32)
    carcinoma mucinous 77.4 22 12493022 (3), 12352188 (3), 17316416 (2), 11253133 (1) (see all 13)
    airways disease 71.9 3 17200179 (1), 18539955 (1), 15205558 (1)
    gastric carcinoma 71.8 60 15737028 (4), 9036879 (4), 11745219 (3), 15309883 (3) (see all 31)
    adenocarcinoma 71.1 70 14699032 (3), 12877727 (3), 17090193 (2), 15910596 (2) (see all 46)
    carcinoma 64.9 65 10227723 (4), 9495202 (4), 16596179 (4), 15272531 (4) (see all 32)
    adenoma 61.5 59 10767823 (5), 10424888 (3), 10398114 (2), 17342306 (2) (see all 27)
    cholangiocarcinoma 61.3 43 19639217 (4), 9495202 (4), 15213623 (4), 19094709 (2) (see all 15)
    nasal polyps 58.4 31 15513533 (7), 18254322 (4), 20128280 (4), 20422702 (3) (see all 10)
    barrett esophagus 58.2 6 16803684 (1), 17565646 (1), 14535999 (1), 12152167 (1) (see all 6)

    Genetic Association Database (GAD): MUC5AC
    Human Genome Epidemiology (HuGE) Navigator: MUC5AC (8 documents)

    Export disorders for MUC5AC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MUC5AC gene, integrated from 10 sources (see all 694):
    (articles sorted by number of sources associating them with MUC5AC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PubMed id 9588204)1, 3, 9 van de Bovenkamp J.H....Einerhand A.W. (Biochem. Biophys. Res. Commun. 1998)
    2. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PubMed id 7513696)1, 2, 9 Meerzaman D....Rose M.C. (J. Biol. Chem. 1994)
    3. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (PubMed id 19924550)1, 4, 9 Jia Y....Ye W. (amp 2010)
    4. Mucin gene polymorphisms in otitis media patients. (PubMed id 19718741)1, 4, 9 Ubell M.L....Kerschner J.E. (Laryngoscope 2010)
    5. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. (PubMed id 14535999)1, 2, 9 Van de Bovenkamp J.H.... Dekker J. (Helicobacter 2003)
    6. Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PubMed id 8948439)1, 2, 9 Klomp L.W.... Strous G.J. (Biochem. J. 1995)
    7. Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? (PubMed id 7826332)1, 3, 9 Guyonnet Duperat V....Porchet N. (Biochem. J. 1995)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    10. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4586 HGNC: 7515 AceView: MUC5AC Ensembl:ENSG00000215182 euGenes: HUgn4586
    ECgene: MUC5AC H-InvDB: MUC5AC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MUC5AC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC5AC Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MUC5AC gene:
    Search GeneIP for patents involving MUC5AC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MUC5AC   OriGene RNAi products in human, mouse, rat for MUC5AC  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MUC5AC  
     OriGene qSTAR qPCR primer pairs in human, mouse for MUC5AC   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MUC5AC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MUC5AC   OriGene Custom Protein Services for MUC5AC  

     
     
     Block miRNA regulation of human, mouse, rat MUC5AC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MUC5AC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MUC5AC Predesigned siRNA for gene silencing in human, mouse, rat MUC5AC
     QuantiFast Probe-based Assays in human, mouse, rat MUC5AC QuantiTect SYBR Green Assays in human, mouse, rat MUC5AC
     Custom PCR Arrays for MUC5AC Search Chromatin IP Primers for MUC5AC
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MUC5AC  GeneGlobe Interaction Network for MUC5AC
     Regulatory tfbs in MUC5AC promoter
     GenScript Custom Purified and Recombinant Proteins Services for MUC5AC GenScript cDNA clones with any tag delivered in your preferred vector for MUC5AC
     GenScript Custom Assay Services for MUC5AC GenScript Custom overexpressing Cell Line Services for MUC5AC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MUC5AC (MUC5A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MUC5AC antibodies
     MUC5AC proteins
     Antibodies for MUC5AC
     See all of Abcam's Antibodies, Kits and Proteins for MUC5AC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MUC5AC
     Antibodies for MUC5AC
     ELISAs for MUC5AC
     CLIAs for MUC5AC



     Browse ESI BIO Cell Lines and PureStem Progenitors for MUC5AC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MUC5AC
     SwitchGear Promoter luciferase reporter plasmids for MUC5AC
     ThermoFisher Antibody for MUC5AC
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MUC5AC
     Browse compounds at ApexBio
     Search Addgene for plasmids for MUC5AC
      Search eBioscience for proteins for MUC5AC
      Search eBioscience for elisas for MUC5AC
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MUC5AC
     antibodies-online antibodies for MUC5AC (103 products)
     antibodies-online kits for MUC5AC (38 products)
     antibodies-online peptides for MUC5AC
     antibodies-online proteins for MUC5AC (14 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MUC5AC gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4