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Aliases for MUC5AC Gene

Aliases for MUC5AC Gene

  • Mucin 5AC, Oligomeric Mucus/Gel-Forming 2 3 5
  • Mucin 5, Subtypes A And C, Tracheobronchial/Gastric 2 3
  • Mucin-5 Subtype AC, Tracheobronchial 3 4
  • Lewis B Blood Group Antigen 3 4
  • Major Airway Glycoprotein 3 4
  • Tracheobronchial Mucin 3 4
  • Gastric Mucin 3 4
  • MUC5 3 4
  • LeB 3 4
  • TBM 3 4
  • Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene 3
  • Mucin-5AC 3
  • MUC-5AC 4
  • Mucin 3

External Ids for MUC5AC Gene

Previous GeneCards Identifiers for MUC5AC Gene

  • GC11U990089
  • GC11P001169
  • GC11P000972

Summaries for MUC5AC Gene

GeneCards Summary for MUC5AC Gene

MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include Gastric Cancer and Pseudomyxoma Peritonei. Among its related pathways are Immune System and HIV Life Cycle. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5B.

UniProtKB/Swiss-Prot for MUC5AC Gene

  • Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Gene Wiki entry for MUC5AC Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC5AC Gene

Genomics for MUC5AC Gene

Regulatory Elements for MUC5AC Gene

Enhancers for MUC5AC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F001317 1.3 FANTOM5 Ensembl ENCODE 11.3 +160.2 160248 1.2 ZNF366 PRDM1 MUC5AC TOLLIP KRTAP5-3 KRTAP5-6 KRTAP5-5 KRTAP5-1 GC11P001310 LOC105376513
GH11F001326 0.6 ENCODE 11.3 +169.1 169115 0.9 ZNF316 FOXA3 NRF1 BHLHE40 FOS TEAD3 TOLLIP MUC5AC GC11P001310 LOC105376513
GH11F001157 0.2 ENCODE 0.8 +0.2 183 1.8 CTCF SIN3A ZIC2 FOSL1 GATA3 POLR2A FOS MAZ HLF KLF4 MUC5AC GC11M001206
GH11F001202 0.6 ENCODE 0.2 +44.4 44373 0.1 POLR2A ZNF24 ZNF600 B4GALNT4 GC11M001206 MUC5AC
GH11F001203 1.2 Ensembl ENCODE 0.2 +45.6 45563 0.9 CTCF MAX ZIC2 RAD21 RFX5 E2F1 POLR2A ZNF143 SMC3 NFE2 GC11M001206 MUC5AC
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MUC5AC on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MUC5AC gene promoter:

Genomic Location for MUC5AC Gene

1,157,953 bp from pter
1,201,138 bp from pter
43,186 bases
Plus strand

Genomic View for MUC5AC Gene

Genes around MUC5AC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC5AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC5AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC5AC Gene

Proteins for MUC5AC Gene

  • Protein details for MUC5AC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0A096LPK4
    • O60460
    • O76065
    • Q13792
    • Q14425
    • Q658Q1
    • Q7M4S5
    • Q8N4M9
    • Q8WWQ3
    • Q8WWQ4
    • Q8WWQ5

    Protein attributes for MUC5AC Gene

    5654 amino acids
    Molecular mass:
    585570 Da
    Quaternary structure:
    • Multimeric. Interacts with H.pylori in the gastric epithelium, Barretts esophagus as well as in gastric metaplasia of the duodenum (GMD).
    • Sequence=AAA18431.1; Type=Erroneous termination; Positions=4999; Note=Translated as Met.; Evidence={ECO:0000305}; Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC15950.1; Type=Frameshift; Positions=24, 44, 671, 683; Evidence={ECO:0000305}; Sequence=CAA88307.1; Type=Frameshift; Positions=5649; Evidence={ECO:0000305}; Sequence=CAH56330.1; Type=Frameshift; Positions=5240, 5247, 5253; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MUC5AC Gene

neXtProt entry for MUC5AC Gene

Post-translational modifications for MUC5AC Gene

  • C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.
  • Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Other Protein References for MUC5AC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC5AC Gene

Domains & Families for MUC5AC Gene

Gene Families for MUC5AC Gene


Graphical View of Domain Structure for InterPro Entry



  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 3 TIL (trypsin inhibitory-like) domains.
  • Contains 4 VWFC domains.
  • Contains 4 VWFD domains.
genes like me logo Genes that share domains with MUC5AC: view

Function for MUC5AC Gene

Molecular function for MUC5AC Gene

GENATLAS Biochemistry:
mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in colorectal neoplasia),expressed in epithelial ovarian cancer
UniProtKB/Swiss-Prot Function:
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Gene Ontology (GO) - Molecular Function for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 7513696
genes like me logo Genes that share ontologies with MUC5AC: view
genes like me logo Genes that share phenotypes with MUC5AC: view

Animal Models for MUC5AC Gene

MGI Knock Outs for MUC5AC:

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC5AC

miRNA for MUC5AC Gene

miRTarBase miRNAs that target MUC5AC

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MUC5AC Gene

Localization for MUC5AC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC5AC Gene


Subcellular locations from

Jensen Localization Image for MUC5AC Gene COMPARTMENTS Subcellular localization image for MUC5AC gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 25591774
GO:0005737 cytoplasm IDA 25591774
GO:0005796 Golgi lumen TAS --
GO:0043205 fibril IDA --
genes like me logo Genes that share ontologies with MUC5AC: view

Pathways & Interactions for MUC5AC Gene

genes like me logo Genes that share pathways with MUC5AC: view

Interacting Proteins for MUC5AC Gene

Selected Interacting proteins: P98088-MUC5A_HUMAN for MUC5AC Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016266 O-glycan processing TAS --
GO:0043206 extracellular fibril organization IDA --
GO:0048015 phosphatidylinositol-mediated signaling IDA 25591774
genes like me logo Genes that share ontologies with MUC5AC: view

No data available for SIGNOR curated interactions for MUC5AC Gene

Drugs & Compounds for MUC5AC Gene

(26) Drugs for MUC5AC Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fudosteine Pharma 0

(27) Additional Compounds for MUC5AC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MUC5AC Gene

Compound Action Cas Number
Fudosteine 13189-98-5
genes like me logo Genes that share compounds with MUC5AC: view

Transcripts for MUC5AC Gene

mRNA/cDNA for MUC5AC Gene

(2) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC5AC Gene

Mucin 5AC, oligomeric mucus/gel-forming:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC5AC Gene

No ASD Table

Relevant External Links for MUC5AC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC5AC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MUC5AC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC5AC Gene

This gene is overexpressed in Stomach (x50.8).

Protein differential expression in normal tissues from HIPED for MUC5AC Gene

This gene is overexpressed in Stomach (16.3), Pancreatic juice (15.3), Nasal epithelium (14.2), and Cardia (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MUC5AC Gene

NURSA nuclear receptor signaling pathways regulating expression of MUC5AC Gene:


SOURCE GeneReport for Unigene cluster for MUC5AC Gene:


mRNA Expression by UniProt/SwissProt for MUC5AC Gene:

Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barretts esophagus epithelium and in the proximal duodenum.
genes like me logo Genes that share expression patterns with MUC5AC: view

Primer Products

No data available for Protein tissue co-expression partners for MUC5AC Gene

Orthologs for MUC5AC Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC5AC Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MUC5AC 34 35
  • 76.45 (n)
(Bos Taurus)
Mammalia LOC100847395 34
  • 76.16 (n)
-- 35
  • 3 (a)
(Mus musculus)
Mammalia Muc5ac 34 16
  • 74.33 (n)
Sspo 35
  • 3 (a)
(Rattus norvegicus)
Mammalia Muc5ac 34
  • 74.32 (n)
(Monodelphis domestica)
Mammalia MUC5AC 35
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 9 (a)
(Gallus gallus)
Aves -- 35
  • 12 (a)
-- 35
  • 8 (a)
(Anolis carolinensis)
Reptilia MUC5AC 35
  • 12 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493937 34
  • 55.7 (n)
(Danio rerio)
Actinopterygii LOC100148804 34
  • 49.24 (n)
muc5ac 35
  • 5 (a)
MUC5AC (3 of 3) 35
  • 5 (a)
MUC5AC (1 of 3) 35
  • 3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hml 35
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 11 (a)
Species where no ortholog for MUC5AC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC5AC Gene

Gene Tree for MUC5AC (if available)
Gene Tree for MUC5AC (if available)

Paralogs for MUC5AC Gene

Variants for MUC5AC Gene

Sequence variations from dbSNP and Humsavar for MUC5AC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111163735 -- 1,155,958(+) ACTTA(C/T)TCATT upstream-variant-2KB
rs111164684 -- 1,187,298(+) NNCAG(A/C)ACAAC reference, missense
rs111164685 -- 1,187,342(+) TGGAA(C/G)TACTC reference, missense
rs111170586 -- 1,156,048(+) TCATT(A/G)ACTCA upstream-variant-2KB
rs111218267 -- 1,169,376(+) ACCCA(C/T)TCACC intron-variant

Variation tolerance for MUC5AC Gene

Gene Damage Index Score: 6.07; 75.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC5AC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC5AC Gene

Disorders for MUC5AC Gene

MalaCards: The human disease database

(58) MalaCards diseases for MUC5AC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
pseudomyxoma peritonei
  • mucinous ascites
pancreatic cancer
  • pancreatic carcinoma, somatic
colorectal cancer
  • colorectal cancer, somatic
anal canal adenocarcinoma
  • adenocarcinoma of anal canal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MUC5AC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC5AC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC5AC Gene

Publications for MUC5AC Gene

  1. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (PMID: 19924550) Jia Y. … Ye W. (Cancer Causes Control 2010) 3 22 46 64
  2. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PMID: 9588204) van de Bovenkamp J.H. … Einerhand A.W. (Biochem. Biophys. Res. Commun. 1998) 2 3 22 64
  3. Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PMID: 8948439) Klomp L.W. … Strous G.J. (Biochem. J. 1995) 3 4 22 64
  4. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PMID: 7513696) Meerzaman D. … Rose M.C. (J. Biol. Chem. 1994) 3 4 22 64
  5. Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium. (PMID: 19556605) Kettle R. … Jones C.E. (Am. J. Respir. Cell Mol. Biol. 2010) 3 22 64

Products for MUC5AC Gene

Sources for MUC5AC Gene

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