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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MUC5AC Gene

protein-coding   GIFtS: 56
GCID: GC11P001151

Mucin 5AC, Oligomeric Mucus/Gel-Forming

(Previous names: mucin 5, subtypes A and C, tracheobronchial/gastric)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mucin 5AC, Oligomeric Mucus/Gel-Forming1 2     Tracheobronchial Mucin2 3
MUC52 3 5     TBM2 3
Mucin 5, Subtypes A And C, Tracheobronchial/Gastric1 2     leB2
Gastric Mucin2 3     Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene2
Lewis B Blood Group Antigen2 3     LeB3
Major Airway Glycoprotein2 3     MUC-5AC3
Mucin-5 Subtype AC, Tracheobronchial2 3     

External Ids:    HGNC: 75151   Entrez Gene: 45862   Ensembl: ENSG000002151827   OMIM: 1583735   UniProtKB: P980883   

Export aliases for MUC5AC gene to outside databases

Previous GC identifers: GC11U990089 GC11P001169 GC11P000972


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MUC5AC Gene: 
MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) is a protein-coding gene. Diseases associated with MUC5AC include anal canal adenocarcinoma, and pancreatic mucinous cystadenoma, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Mucin expression in CF via IL-6, IL-17 signaling pathways. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is ZAN.

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from
infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by
the mucocilary system

Gene Wiki entry for MUC5AC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MUC5AC gene promoter:
         Sp1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMUC5AC promoter sequence
   Search SABiosciences Chromatin IP Primers for MUC5AC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC5AC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

MUC5AC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5AC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001151:  view genomic region     (about GC identifiers)

Start:
1,142,474 bp from pter      End:
1,222,364 bp from pter
Size:
79,891 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088 (See protein sequence)
Recommended Name: Mucin-5AC precursor  
Size: 5030 amino acids; 526608 Da
Subunit: Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric
metaplasia of the duodenum (GMD)
Subcellular location: Secreted
Sequence caution: Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Sequence=AAC15950.1; Type=Frameshift;
Positions=24, 44, 671, 683; Sequence=CAA88307.1; Type=Frameshift; Positions=5024; Sequence=CAH56330.1;
Type=Frameshift; Positions=4616;
Secondary accessions: O60460 O76065 Q13792 Q14425 Q658Q1 Q7M4S5 Q8N4M9 Q8WWQ3 Q8WWQ4 Q8WWQ5

Explore the universe of human proteins at neXtProt for MUC5AC: NX_P98088

Explore proteomics data for MUC5AC at MOPED 

Post-translational modifications:

  • UniProtKB: C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich
    subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum
    during biosynthesis
  • UniProtKB: Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine
    protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a
    reactive group which could link the protein to a primary amide
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P98088

  • MUC5AC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MUC5AC Protein Expression

    ENSEMBL proteins: 
     ENSP00000435591   ENSP00000348519  
    Reactome Protein details: P98088
    Human Recombinant Protein Products for MUC5AC: 
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    Cloud-Clone Corp. Proteins for MUC5AC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005796Golgi lumen TAS--
    GO:0043205fibril IDA14749330

    MUC5AC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MUC: Mucins

    5/6 InterPro protein domains (see all 6):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR002919 TIL_dom
     IPR025155 WxxW_domain
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry P98088

    ProtoNet protein and cluster: P98088

    4 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006207 Cystine knot


    UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
    Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 2 VWFC domains
    Similarity: Contains 4 VWFD domains


    MUC5AC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC5A_HUMAN, P98088
    Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from
    infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by
    the mucocilary system

         Genatlas biochemistry entry for MUC5AC:
    mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin
    cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in
    colorectal neoplasia),expressed in epithelial ovarian cancer

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS7513696
         
    MUC5AC for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MUC5AC:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Muc5ac):
     digestive/alimentary  homeostasis/metabolism  immune system 

    MUC5AC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Muc5actm1.1Tigm for MUC5AC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MUC5AC 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MUC5AC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    3Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    4Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MUC5AC
        Selected targets of CREB1


    2 GeneGo (Thomson Reuters) Pathways for MUC5AC
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    4        Reactome Pathways for MUC5AC
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis



    MUC5AC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MUC5AC

    1 Interacting protein for MUC5AC (P980883) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--
    GO:0007586digestion NAS--
    GO:0016266O-glycan processing TAS--
    GO:0043206extracellular fibril organization IDA10611155
    GO:0043687post-translational protein modification TAS--

    MUC5AC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MUC5AC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MUC5AC (MUC5A)

    10/52 Novoseek inferred chemical compound relationships for MUC5AC gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 54.8 2 12972643 (1), 15864435 (1)
    niflumic acid 49.2 6 17426222 (2), 17622767 (1), 15696080 (1), 16465045 (1)
    threonine 39.8 3 10410928 (1), 12386453 (1), 9618923 (1)
    serine 32.7 5 20216230 (1), 10330040 (1), 12386453 (1), 9618923 (1) (see all 5)
    pd 98,059 31.1 5 16009452 (1), 12391274 (1), 16773182 (1), 16377262 (1)
    proline 29.6 1 8207007 (1)
    carbohydrates 28.9 3 10697417 (1), 11102566 (1), 11425189 (1)
    periodate 28.3 2 11425189 (1)
    mnng 27.7 1 17066439 (1)
    trifluoromethanesulfonic acid 24.7 3 8699025 (1), 1310044 (1)

    Search CenterWatch for drugs/clinical trials and news about MUC5AC / MUC5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MUC5AC gene: 
    NM_017511.1  

    Unigene Clusters for MUC5AC:

    Mucin 5AC, oligomeric mucus/gel-forming
    Hs.534332  [show with all ESTs], Hs.558950  [show with all ESTs], Hs.721515  [show with all ESTs]
    Unigene Representative Sequences: AJ001402, X81649, AJ298317
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534821(uc021qbr.1) ENST00000358378(uc001lsz.3 uc009ycs.2)
    ENST00000356191
    miRNA
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    Additional mRNA sequence: 

    AF015521.1 AF043909.1 AJ298317.1 

    6 DOTS entries:

    DT.209839  DT.75121497  DT.91804067  DT.95323046  DT.95264442  DT.91804068 

    24/65 AceView cDNA sequences (see all 65):

    AI828184 AI925608 AW298301 Z48314 BM855872 AL833060 CA433820 BC033831 
    BM769723 BI761970 BI762047 BM782247 AI924115 BM820970 BV174347 BV204711 
    BM784694 AI677639 AJ001402 BM854880 BV174348 BV178834 BV178294 AI921630 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MUC5AC expression in normal human tissues (normalized intensities)      MUC5AC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTTACA
    MUC5AC Expression
    About this image


    MUC5AC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Mucus-producing Cells Trachea
             Early proximal lung progenitors ( Directed differentiation of human embryonic stem...
             Trachea   
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelia   
     
     Nose (Sensory Organs)
             nasal epithelium   
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Pancreas (Endocrine System)

    See MUC5AC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MUC5AC

    SOURCE GeneReport for Unigene clusters: Hs.534332 Hs.558950 Hs.721515

    UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088
    Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia.
    Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal
    duodenum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MUC5AC gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Muc5ac5 mucin 5, subtypes A and C, tracheobronchial/gastric   --   7 (87.23 cM) 141788972 
    chicken
    (Gallus gallus)
    Aves MUC5AC6
    MUC5B6
    Mucin-5B
    8(a)
    11(a)
    1 ↔ 1
    possible ortholog
    5(14079795-14176709)
    5(14243984-14284324)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    8(a)
    12(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    1(72015518-72092559)
    1(71905642-71976150)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    MUC5AC6
    (see all 4)
    mucin 5AC, oligomeric mucus/gel-forming
    (see all 4)
    8(a)
    5(a)
    (see all 4)
    possible ortholog
    1 ↔ 1
    (see all 4)
    25(8564866-8607907)
    7(74859528-74903390)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hml6
    Hemolectin
    3(a)
    1 → many
    3L(13839154-13853101)


    ENSEMBL Gene Tree for MUC5AC (if available)
    TreeFam Gene Tree for MUC5AC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MUC5AC gene
    ZAN2  TECTA2  OTOG2  OTOGL2  MUC5B2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    6 SIMAP similar genes for MUC5AC using alignment to 16 protein entries:     MUC5A_HUMAN (see all proteins):
    MG1    MUC5B    MLP    MUC2    OTOG    MUC19

    MUC5AC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MUC5AC
    PGOHUM00000258306


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 SNPs in MUC5AC are shown (see all 57)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0368324
    ----see VAR_0368322 L P mis40--------
    rs287374161,2
    C,F--979361(+) CGGCAC/TACAGG 2 H syn114Minor allele frequency- T:0.38NS NA WA CSA EA 542
    rs1890369511,2
    C--980851(+) CTGTGC/TGGGGC 1 -- int10--------
    rs285507251,2
    C--980861(+) CTGTGC/TGGGGC 1 -- int10--------
    rs2013021501,2
    --980862(+) TGTGT-/GGGG  
      CTGTGC
    GGGGC
    1 -- int10--------
    rs1456667251,2
    C--980871(+) CTGTGC/TGGGGC 1 -- int10--------
    rs1923366071,2
    --980881(+) CTGTGC/TGGGGC 1 -- int10--------
    rs286912311,2
    C,F--985738(+) CCCTGC/TGCAGA 2 C syn120Minor allele frequency- T:0.14NA NS WA CSA EA EU 1117
    rs289727531,2
    F--986241(+) TGTCCC/TGGGCC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs289729601,2
    C,F--986273(+) TGTCCC/TGGGCC 1 -- int12Minor allele frequency- T:0.50NA WA 4

    HapMap Linkage Disequilibrium report for MUC5AC (1142474 - 1222364 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MUC5AC: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MUC5AC
    DNA2.0 Custom Variant and Variant Library Synthesis for MUC5AC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 158373    OMIM disorders: --

    20/94 diseases for MUC5AC (see all 94):    About MalaCards
    anal canal adenocarcinoma    pancreatic mucinous cystadenoma    biliary papillomatosis    ampulla of vater adenocarcinoma
    hidradenocarcinoma    limbal stem cell deficiency    atopic keratoconjunctivitis    ovarian mucinous adenocarcinoma
    corneal ulcer    pseudomyxoma peritonei    cholangiocarcinoma    barrett's esophagus
    epstein-barr virus-associated gastric carcinoma    small intestine adenocarcinoma    dry eye syndrome    mucinous adenocarcinoma
    status asthmaticus    diverticulitis    otitis media    ampulla of vater carcinoma


    MUC5AC for disorders           About GeneDecksing

    10/93 Novoseek inferred disease relationships for MUC5AC gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metaplasia 81.1 55 10070955 (4), 10190312 (3), 17090193 (2), 14631367 (2) (see all 32)
    carcinoma mucinous 77.4 22 12493022 (3), 12352188 (3), 17316416 (2), 11253133 (1) (see all 13)
    airways disease 71.9 3 17200179 (1), 18539955 (1), 15205558 (1)
    gastric carcinoma 71.8 60 15737028 (4), 9036879 (4), 11745219 (3), 15309883 (3) (see all 31)
    adenocarcinoma 71.1 70 14699032 (3), 12877727 (3), 17090193 (2), 15910596 (2) (see all 46)
    carcinoma 64.9 65 10227723 (4), 9495202 (4), 16596179 (4), 15272531 (4) (see all 32)
    adenoma 61.5 59 10767823 (5), 10424888 (3), 10398114 (2), 17342306 (2) (see all 27)
    cholangiocarcinoma 61.3 43 19639217 (4), 9495202 (4), 15213623 (4), 19094709 (2) (see all 15)
    nasal polyps 58.4 31 15513533 (7), 18254322 (4), 20128280 (4), 20422702 (3) (see all 10)
    barrett esophagus 58.2 6 16803684 (1), 17565646 (1), 14535999 (1), 12152167 (1) (see all 6)

    Genetic Association Database (GAD): MUC5AC
    Human Genome Epidemiology (HuGE) Navigator: MUC5AC (8 documents)

    Export disorders for MUC5AC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MUC5AC gene, integrated from 9 sources (see all 684):
    (articles sorted by number of sources associating them with MUC5AC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PubMed id 9588204)1, 3, 9 van de Bovenkamp J.H....Einerhand A.W. (1998)
    2. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PubMed id 7513696)1, 2, 9 Meerzaman D....Rose M.C. (1994)
    3. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (PubMed id 19924550)1, 4, 9 Jia Y....Ye W. (2010)
    4. Mucin gene polymorphisms in otitis media patients. (PubMed id 19718741)1, 4, 9 Ubell M.L....Kerschner J.E. (2010)
    5. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. (PubMed id 14535999)1, 2, 9 Van de Bovenkamp J.H.... Dekker J. (2003)
    6. Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PubMed id 8948439)1, 2, 9 Klomp L.W.... Strous G.J. (1995)
    7. Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? (PubMed id 7826332)1, 3, 9 Guyonnet Duperat V....Porchet N. (1995)
    8. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    10. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4586 HGNC: 7515 AceView: MUC5AC Ensembl:ENSG00000215182 euGenes: HUgn4586
    ECgene: MUC5AC H-InvDB: MUC5AC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MUC5AC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MUC5AC Genetics and Cytogenetics in Oncology and Haematology
    Mucin databasehttp://www.medkem.gu.se/mucinbiology/databases/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MUC5AC gene:
    Search GeneIP for patents involving MUC5AC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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