 |
 | Services
| |
 |
Aliases &
Descriptions
for MUC5AC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| LeB 3 | | MUC5 1, 2, 3, 5 | | TBM 3 |
| | | Descriptions |
|---|
| Gastric mucin 2, 3 | | Lewis B blood group antigen 3 | | Major airway glycoprotein 3 | | Mucin-5 subtype AC, tracheobronchial 3 | | Tracheobronchial mucin 2, 3 | | mucin 5, subtypes A and C, tracheobronchial/gastric 1, 2 | | mucin 5AC 2 | | mucin 5AC, oligomeric mucus/gel-forming 2 |
|
| |
Search outside databases for aliases for MUC5AC genePrevious GC identifer: GC11U990089 |
Summaries
for MUC5AC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the
mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that
are subsequently removed by the mucocilary systemGene Wiki entry for MUC5AC |
Genomic Location
for MUC5AC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the MUC5AC gene 
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5MUC5AC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P001169:
(about GC identifiers)
Start:
|
1,152,663 bp from pter |
End:
|
1,178,940 bp from pter |
Size:
|
26,278 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 1,141,627-1,152,360 |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins
for MUC5AC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088 (See
protein sequence)Recommended Name: Mucin-5AC precursor Size: 5030 amino acids; 526608 Da
Subunit: Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well
as in gastric metaplasia of the duodenum (GMD)
Subcellular location: Secreted
Sequence caution: Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Sequence=AAC15950.1;
Type=Frameshift; Positions=24, 44, 671, 683; Sequence=CAA88307.1; Type=Frameshift; Positions=5024;
Sequence=CAH56330.1; Type=Frameshift; Positions=4616;
Secondary accessions: O60460 O76065 Q13792 Q14425 Q658Q1 Q7M4S5 Q8N4M9 Q8WWQ3 Q8WWQ4 Q8WWQ5Post-translational modifications:
C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in
the Cys-rich subdomains may be required for proper folding of these regions and for export from
the endoplasmic reticulum during biosynthesis1
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not
involve a serine protease. The extent of cleavage is increased in the acidic parts of the
secretory pathway. Cleavage generates a reactive group which could link the protein to a primary
amide1
REFSEQ proteins: NP_059981.1
ENSEMBL proteins: ENSP00000371671 ENSP00000351148
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for MUC5AC:
Assays for MUC5AC: | Protein
Domains/
Families
for MUC5AC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P98088
ProtoNet protein and cluster: P98088 4 Blocks protein families: IPB001007 von Willebrand factor IPB001846 Von Willebrand factor IPB002919 Trypsin inhibitor-like IPB006207 Cystine knot
UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide
bondingSimilarity: Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity: Contains 2 VWFC domainsSimilarity: Contains 4 VWFD domains | Gene Function
for MUC5AC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
 Applied Biosystems Silencer® siRNAs for MUC5AC
 Sigma-Aldrich siRNA for MUC5AC
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Browse Origene for untagged/tagged cDNA clones in CMV expression vector
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_017511
UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the
mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that
are subsequently removed by the mucocilary systemGenatlas biochemistry entry for MUC5AC:mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the
secreted mucin cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell
differentiation (aberrant expression in colorectal neoplasia),expressed in epithelial ovarian
cancer3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0030197 | extracellular matrix constituent, lubricant activity |
NAS | -- |
About this table | Pathways & Interactions
for MUC5AC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for MUC5AC
--5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds
for MUC5AC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MUC5AC
10/29  Novoseek chemical compound relationships for MUC5AC gene (see all 29
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
41.99 |
3 |
10410928 (1), 12386453 (1), 9618923 (1) |
| proline |
32.06 |
1 |
8207007 (1) |
| periodate |
30.30 |
2 |
11425189 (1) |
| mnng |
29.53 |
1 |
17066439 (1) |
| trifluoromethanesulfonic acid |
27.64 |
3 |
8699025 (1), 1310044 (1) |
| cesium chloride |
26.66 |
1 |
14960375 (1) |
| pd 98,059 |
25.91 |
5 |
16009452 (1), 12391274 (1), 16773182 (1), 16377262 (1) |
| chloride |
17.79 |
9 |
16465045 (3), 19106979 (2), 18597857 (1), 17698377 (1) |
| oligonucleotide |
10.68 |
5 |
11129031 (1), 11673830 (1), 8997274 (1), 17851936 (1) (see all 5) |
| hematoxylin |
3.24 |
1 |
17621824 (1) |
About this table
|
Transcripts
for MUC5AC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for MUC5AC
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_017511 REFSEQ mRNAs for MUC5AC gene: NM_017511.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017511
Browse Origene for untagged/tagged cDNA clones in CMV expression vector
Additional cDNA sequence: AF015521.1 AF043909.1 AJ298317.1 X81649.1 XM_001714045.1 Z34280.1 Z34281.1 Z34282.1 10 DOTS entries: DT.209839 DT.75121497 DT.91804067 DT.95323046 DT.40195242 DT.95264442 DT.91677252 DT.100892739 DT.91736039 DT.91804068 24/65 AceView cDNA sequences (see all 65
):AI677639 BM820970 BM769723 AW298301 AJ001402 BV178834 BI762047 BM854880 BC033831 Z48314 BM784694 AI921630 AI925608 BM782247 BV178294 BV174348 AI828184 BV204711 AI924115 CA433820 BV174347 BM855872 BI761970 AL833060
 highest scoring ESTs for MUC5AC:AF015521 AF043909 AJ298317 AA113192 AA159577 AI074391 AI362473 AI445479 AI445655 AI446712 Unigene Clusters for MUC5AC: Mucin 5AC, oligomeric mucus/gel-forming Hs.534332 [show with all ESTs], Hs.558950 [show with all ESTs]Unigene Representative Sequences: AJ001402, NM_017511
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000382236
ENST00000358378
|
Expression
for MUC5AC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MUC5AC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MUC5AC
1 / 2 / 3 11 probe-sets matching MUC5AC gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.534332 Hs.558950
Expression variation in blood from EXPOLDB for MUC5AC UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach
epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus
epithelium and in the proximal duodenum |
Orthologs
for MUC5AC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MUC5AC gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Muc5ac5 |
7 (69.00 cM) |
mucin 5, subtypes A and C, tracheobronchial/gastric |
-- |
L42292
|
About this table Species with no ortholog for MUC5AC
ENSEMBL Gene Tree for MUC5AC | Paralogs
for MUC5AC(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MUC5AC gene
- ENSG000001790662 ZAN2 FCGBP2
|
SNPs/Variants
for MUC5AC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MUC5AC (up to first 250kb)
|
Disorders & Mutations
for MUC5AC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 158373
10/91 Novoseek disease relationships for MUC5AC gene (see all 91
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metaplasia |
80.98 |
55 |
10070955 (4), 10190312 (3), 17090193 (2), 14631367 (2) (see all 32) |
| carcinoma mucinous |
75.81 |
20 |
12493022 (3), 12352188 (3), 17316416 (2), 11253133 (1) (see all 12) |
| gastric carcinoma |
72.53 |
59 |
15737028 (4), 9036879 (4), 11745219 (3), 15309883 (3) (see all 30) |
| adenocarcinoma |
70.99 |
65 |
14699032 (3), 12877727 (3), 17090193 (2), 15910596 (2) (see all 43) |
| airways disease |
69.71 |
3 |
17200179 (1), 18539955 (1), 15205558 (1) |
| carcinoma |
65.00 |
65 |
10227723 (4), 9495202 (4), 16596179 (4), 15272531 (4) (see all 32) |
| cholangiocarcinoma |
61.66 |
35 |
9495202 (4), 15213623 (4), 19094709 (2), 12495310 (2) (see all 14) |
| adenoma |
61.48 |
56 |
10767823 (5), 10424888 (3), 10398114 (2), 17342306 (2) (see all 26) |
| barrett esophagus |
57.72 |
6 |
16803684 (1), 17565646 (1), 14535999 (1), 12152167 (1) (see all 6) |
| nasal polyps |
56.05 |
23 |
15513533 (7), 18254322 (4), 15715404 (2), 17621824 (2) (see all 8) |
About this table
Genetic Association Database: MUC5AC
Human Genome Epidemiology Navigator: MUC5AC (4 documents)
|
Medical News
for MUC5AC(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MUC5AC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/551 PubMed articles for MUC5AC gene (see all 551
):- Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PubMed id 9588204)1, 2, 3 van de Bovenkamp J.H....Einerhand A.W. (1998)
- Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PubMed id 7513696)1, 3, 4 Meerzaman D....Rose M.C. (1994)
- The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. (PubMed id 14535999)1, 3, 4 Van de Bovenkamp J.H.... Dekker J. (2003)
- Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? (PubMed id 7826332)1, 2, 3 Guyonnet Duperat V....Porchet N. (1995)
- Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. (PubMed id 16787389)3, 4 Lidell M.E. and Hansson G.C. (2006)
- Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. (PubMed id 11535137)3, 4 Escande F.... Buisine M.P. (2001)
- In vivo glycosylation of mucin tandem repeats. (PubMed id 11445551)3, 4 Silverman H.S....Harris A. (2001)
- Polymorphism of human mucin genes in chest disease: possible significance of MUC2. (PubMed id 11062147)3, 6 Vinall L.E....Swallow D.M. (2000)
- Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. (PubMed id 9506983)3, 4 Li D.... Basbaum C.B. (1998)
- Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family. (PubMed id 9620876)3, 4 Buisine M.P....Aubert J.-P. (1998)
|
Search for MUC5AC
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MUC5AC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MUC5AC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MUC5AC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MUC5AC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MUC5AC:
 | |
 | | | | |
 |
 |  |  | |
| | |  | Search Tocris compounds for MUC5AC |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
