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Aliases for MUC5AC Gene

Aliases for MUC5AC Gene

  • Mucin 5AC, Oligomeric Mucus/Gel-Forming 2 3
  • MUC5 3 4 6
  • Mucin 5, Subtypes A And C, Tracheobronchial/Gastric 2 3
  • Mucin-5 Subtype AC, Tracheobronchial 3 4
  • Lewis B Blood Group Antigen 3 4
  • Major Airway Glycoprotein 3 4
  • Tracheobronchial Mucin 3 4
  • Gastric Mucin 3 4
  • LeB 3 4
  • TBM 3 4
  • Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene 3
  • Mucin-5AC 3
  • MUC-5AC 4
  • Mucin 3

External Ids for MUC5AC Gene

Previous GeneCards Identifiers for MUC5AC Gene

  • GC11U990089
  • GC11P001169
  • GC11P000972

Summaries for MUC5AC Gene

GeneCards Summary for MUC5AC Gene

MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include anal canal adenocarcinoma and pancreatic mucinous cystadenoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OTOGL.

UniProtKB/Swiss-Prot for MUC5AC Gene

  • Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system

Gene Wiki entry for MUC5AC Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC5AC Gene

Genomics for MUC5AC Gene

Regulatory Elements for MUC5AC Gene

Transcription factor binding sites by QIAGEN in the MUC5AC gene promoter:

Genomic Location for MUC5AC Gene

Start:
1,157,953 bp from pter
End:
1,201,138 bp from pter
Size:
43,186 bases
Orientation:
Plus strand

Genomic View for MUC5AC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC5AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC5AC Gene

Proteins for MUC5AC Gene

  • Protein details for MUC5AC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98088-MUC5A_HUMAN
    Recommended name:
    Mucin-5AC
    Protein Accession:
    P98088
    Secondary Accessions:
    • A0A096LPK4
    • O60460
    • O76065
    • Q13792
    • Q14425
    • Q658Q1
    • Q7M4S5
    • Q8N4M9
    • Q8WWQ3
    • Q8WWQ4
    • Q8WWQ5

    Protein attributes for MUC5AC Gene

    Size:
    5654 amino acids
    Molecular mass:
    585570 Da
    Quaternary structure:
    • Multimeric. Interacts with H.pylori in the gastric epithelium, Barretts esophagus as well as in gastric metaplasia of the duodenum (GMD).
    SequenceCaution:
    • Sequence=AAA18431.1; Type=Erroneous termination; Positions=4999; Note=Translated as Met.; Evidence={ECO:0000305}; Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC15950.1; Type=Frameshift; Positions=24, 44, 671, 683; Evidence={ECO:0000305}; Sequence=CAA88307.1; Type=Frameshift; Positions=5649; Evidence={ECO:0000305}; Sequence=CAH56330.1; Type=Frameshift; Positions=5240, 5247, 5253; Evidence={ECO:0000305};

neXtProt entry for MUC5AC Gene

Proteomics data for MUC5AC Gene at MOPED

Post-translational modifications for MUC5AC Gene

  • C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.
  • Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
  • Glycosylation at Asn205, Asn258, Asn415, Asn524, Asn1308, Trp1389, Trp1584, Trp1749, Trp1957, Trp2122, Trp2652, Trp2950, Asn3198, Trp3383, Trp4009, Asn4245, Asn4318, Asn4433, Asn4469, Asn4612, Asn4723, Asn4753, Asn4762, Asn4831, Asn4904, and Asn4967

Other Protein References for MUC5AC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MUC5AC Gene

Domains for MUC5AC Gene

Gene Families for MUC5AC Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P98088

UniProtKB/Swiss-Prot:

MUC5A_HUMAN :
  • P98088
Domain:
  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 3 TIL (trypsin inhibitory-like) domains.
  • Contains 4 VWFC domains.
  • Contains 4 VWFD domains.
genes like me logo Genes that share domains with MUC5AC: view

Function for MUC5AC Gene

Molecular function for MUC5AC Gene

GENATLAS Biochemistry: mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in colorectal neoplasia),expressed in epithelial ovarian cancer
UniProtKB/Swiss-Prot Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system

Gene Ontology (GO) - Molecular Function for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 7513696
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MUC5AC: view
genes like me logo Genes that share phenotypes with MUC5AC: view

Animal Models for MUC5AC Gene

MGI Knock Outs for MUC5AC:

Animal Model Products

miRNA for MUC5AC Gene

miRTarBase miRNAs that target MUC5AC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MUC5AC Gene

Localization for MUC5AC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC5AC Gene

Secreted.

Gene Ontology (GO) - Cellular Components for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25591774
GO:0005737 cytoplasm IDA 25591774
GO:0005796 Golgi lumen TAS --
GO:0043205 fibril IDA 14749330
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MUC5AC: view

No data available for Subcellular locations from COMPARTMENTS for MUC5AC Gene

Pathways for MUC5AC Gene

genes like me logo Genes that share pathways with MUC5AC: view

Interacting Proteins for MUC5AC Gene

Selected Interacting proteins: P98088-MUC5A_HUMAN for MUC5AC Gene via I2D

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043206 extracellular fibril organization IDA 10611155
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC5AC: view

Compounds for MUC5AC Gene

(52) Novoseek inferred chemical compound relationships for MUC5AC Gene

Compound -log(P) Hits PubMed IDs
ag 1478 54.8 2
niflumic acid 49.2 5
threonine 39.8 3
serine 32.7 5
pd 98,059 31.1 4
genes like me logo Genes that share compounds with MUC5AC: view

Transcripts for MUC5AC Gene

mRNA/cDNA for MUC5AC Gene

(17) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC5AC Gene

Mucin 5AC, oligomeric mucus/gel-forming:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MUC5AC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC5AC Gene

No ASD Table

Relevant External Links for MUC5AC Gene

GeneLoc Exon Structure for
MUC5AC
ECgene alternative splicing isoforms for
MUC5AC

Expression for MUC5AC Gene

mRNA expression in normal human tissues for MUC5AC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC5AC Gene

This gene is overexpressed in Stomach (50.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MUC5AC Gene

SOURCE GeneReport for Unigene cluster for MUC5AC Gene Hs.534332

mRNA Expression by UniProt/SwissProt for MUC5AC Gene

P98088-MUC5A_HUMAN
Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barretts esophagus epithelium and in the proximal duodenum.
genes like me logo Genes that share expressions with MUC5AC: view

In Situ Assay Products

Orthologs for MUC5AC Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC5AC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 3 (a)
ManyToMany
LOC100847395 35
  • 76.16 (n)
  • 69.3 (a)
dog
(Canis familiaris)
Mammalia MUC5AC 35
  • 76.45 (n)
  • 70.79 (a)
MUC5AC 36
  • 8 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc5ac 35
  • 74.33 (n)
  • 70.46 (a)
Muc5ac 16
Sspo 36
  • 3 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia MUC5AC 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 9 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Muc5ac 35
  • 74.32 (n)
  • 70.23 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 8 (a)
OneToMany
-- 36
  • 12 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MUC5AC 36
  • 12 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493937 35
  • 55.7 (n)
  • 52.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148804 35
  • 49.24 (n)
  • 41.71 (a)
muc5ac 36
  • 5 (a)
OneToMany
MUC5AC (1 of 3) 36
  • 3 (a)
OneToMany
MUC5AC (3 of 3) 36
  • 5 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hml 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
ManyToMany
Species with no ortholog for MUC5AC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC5AC Gene

ENSEMBL:
Gene Tree for MUC5AC (if available)
TreeFam:
Gene Tree for MUC5AC (if available)

Paralogs for MUC5AC Gene

Paralogs for MUC5AC Gene

Pseudogenes.org Pseudogenes for MUC5AC Gene

genes like me logo Genes that share paralogs with MUC5AC: view

Variants for MUC5AC Gene

Sequence variations from dbSNP and Humsavar for MUC5AC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11347 -- 1,201,099(+) GTACA(C/T)GGCCA utr-variant-3-prime
rs13010 -- 1,201,051(+) GAAGA(A/C)CCTCA utr-variant-3-prime
rs13380 -- 1,201,105(+) GGCCA(A/G)TCTGT utr-variant-3-prime
rs1132433 -- 1,194,354(+) ATGAC(A/G)AACGA reference, synonymous-codon
rs1132434 -- 1,195,265(+) TGCCA(C/G)CTGAT missense, reference

Relevant External Links for MUC5AC Gene

HapMap Linkage Disequilibrium report
MUC5AC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC5AC Gene

Disorders for MUC5AC Gene

(93) Novoseek inferred disease relationships for MUC5AC Gene

Disease -log(P) Hits PubMed IDs
metaplasia 81.1 40
carcinoma mucinous 77.4 18
airways disease 71.9 3
gastric carcinoma 71.8 51
adenocarcinoma 71.1 59

Relevant External Links for MUC5AC

Genetic Association Database (GAD)
MUC5AC
Human Genome Epidemiology (HuGE) Navigator
MUC5AC
genes like me logo Genes that share disorders with MUC5AC: view

No data available for UniProtKB/Swiss-Prot for MUC5AC Gene

Publications for MUC5AC Gene

  1. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PMID: 9588204) van de Bovenkamp J.H. … Einerhand A.W. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  2. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PMID: 7513696) Meerzaman D. … Rose M.C. (J. Biol. Chem. 1994) 3 4 23
  3. Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PMID: 8948439) Klomp L.W. … Strous G.J. (Biochem. J. 1995) 3 4 23
  4. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. (PMID: 14535999) Van de Bovenkamp J.H. … Dekker J. (Helicobacter 2003) 3 4 23
  5. Mucin gene polymorphisms in otitis media patients. (PMID: 19718741) Ubell M.L. … Kerschner J.E. (Laryngoscope 2010) 3 23 48

Products for MUC5AC Gene

Sources for MUC5AC Gene

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