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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MUC5AC Gene

protein-coding GIFtS: 54
GCID: GC11P001151

mucin 5AC, oligomeric mucus/gel-forming

(Previous names: mucin 5, subtypes A and C, tracheobronchial/gastric )

Explore 110 diseases affiliated with
MUC5AC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mucin 5AC, Oligomeric Mucus/Gel-Forming¹ ²		Tracheobronchial Mucin² ³
MUC5¹ ² ³ ⁵		TBM² ³
Mucin 5, Subtypes A And C, Tracheobronchial/Gastric¹ ²		LeB³
Gastric Mucin² ³		Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene²
Lewis B Blood Group Antigen² ³		Mucin-5AC¹
Major Airway Glycoprotein² ³		LeB³
Mucin-5 Subtype AC, Tracheobronchial² ³		MUC-5AC³

External Ids:	HGNC: 7515¹	Entrez Gene: 4586²	Ensembl: ENSG00000215182⁷	OMIM: 158373⁵	UniProtKB: P98088³

Export aliases for MUC5AC gene to outside databases

Previous GC identifers: GC11U990089 GC11P001169 GC11P000972

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088

Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection

and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary

system

Gene Wiki entry for MUC5AC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MUC5AC gene promoter:
Sp1 p53
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MUC5AC promoter sequence

Search SABiosciences Chromatin IP Primers for MUC5AC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MUC5AC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

MUC5AC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MUC5AC gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P001151: view genomic region (about GC identifiers)

Start:	1,151,580 bp from pter	End:	1,222,364 bp from pter
Size:	70,785 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088 (See protein sequence)

Recommended Name: Mucin-5AC precursor

Size: 5030 amino acids; 526608 Da

Subunit: Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric

metaplasia of the duodenum (GMD)

Subcellular location: Secreted

Sequence caution: Sequence=AAA18431.1; Type=Frameshift; Positions=Several; Sequence=AAC15950.1; Type=Frameshift;

Positions=24, 44, 671, 683; Sequence=CAA88307.1; Type=Frameshift; Positions=5024; Sequence=CAH56330.1;

Type=Frameshift; Positions=4616;

Secondary accessions: O60460 O76065 Q13792 Q14425 Q658Q1 Q7M4S5 Q8N4M9 Q8WWQ3 Q8WWQ4 Q8WWQ5

Explore the universe of human proteins at neXtProt for MUC5AC: NX_P98088

Post-translational modifications:

C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich

subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during

biosynthesis¹

Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine

protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a

reactive group which could link the protein to a primary amide¹

View neXtProt modification sites for NX_P98088

MUC5AC Protein expression data from MOPED and PaxDb: About this image

ENSEMBL proteins:

ENSP00000435591 ENSP00000348519

Reactome Protein details: P98088
Human Recombinant Protein Products:

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	Uscn Proteins for MUC5AC

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005796	Golgi lumen	TAS	--
GO:0043205	fibril	IDA	14749330
GO:0044464	cell part	--	--

MUC5AC for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MUC5AC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MUC5AC for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014853 Unchr_dom_Cys-rich

IPR002919 TIL_dom

IPR006207 Cys_knot_C

IPR025155 WxxW_domain

IPR001007 VWF_C

Graphical View of Domain Structure for InterPro Entry P98088

ProtoNet protein and cluster: P98088

4 Blocks protein families:

IPB001007 von Willebrand factor

IPB001846 Von Willebrand factor

IPB002919 Trypsin inhibitor-like

IPB006207 Cystine knot

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088

Domain: The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding

Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain

Similarity: Contains 2 VWFC domains

Similarity: Contains 4 VWFD domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088

Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection

and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary

system

Genatlas biochemistry entry for MUC5AC:

mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin

cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in

colorectal neoplasia),expressed in epithelial ovarian cancer

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	TAS	7513696
GO:0005515	protein binding	--	--

MUC5AC for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for MUC5AC:

Decreased Salmonella enterica

Animal Models:
Mouse knock-out Muc5ac^tm1.1Tigm for MUC5AC
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Muc5ac):

digestive/alimentary

homeostasis/metabolism

immune system

MUC5AC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein	1.00	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein	1.00
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein	1.00	Termination of O-glycan biosynthesis	0.69
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein	1.00	O-linked glycosylation of mucins	0.28

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Asparagine N-linked glycosylation

Post-translational protein modification

0.44

Metabolism of proteins

0.15

Selected targets of CREB1

Selected targets of CREB1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MUC5AC

Selected targets of CREB1

2 GeneGo (Thomson Reuters) Pathways for MUC5AC

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Mucin expression in CF via IL-6, IL-17 signaling pathways

5/8 Reactome Pathways for MUC5AC (see all 8)

	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
	O-linked glycosylation of mucins
	Metabolism of proteins
	Post-translational protein modification
	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein

MUC5AC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MUC5AC

1 Interacting protein for MUC5AC (P98088³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	--
GO:0007586	digestion	NAS	--
GO:0016266	O-glycan processing	TAS	--
GO:0043206	extracellular fibril organization	IDA	10611155
GO:0043687	post-translational protein modification	TAS	--

MUC5AC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MUC5AC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MUC5AC
10/52 Novoseek chemical compound relationships for MUC5AC gene (see all 52) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ag 1478	54.8	2	12972643 (1), 15864435 (1)
niflumic acid	49.2	6	17426222 (2), 17622767 (1), 15696080 (1), 16465045 (1)
threonine	39.8	3	10410928 (1), 12386453 (1), 9618923 (1)
serine	32.7	5	20216230 (1), 10330040 (1), 12386453 (1), 9618923 (1) (see all 5)
pd 98,059	31.1	5	16009452 (1), 12391274 (1), 16773182 (1), 16377262 (1)
proline	29.6	1	8207007 (1)
carbohydrates	28.9	3	10697417 (1), 11102566 (1), 11425189 (1)
periodate	28.3	2	11425189 (1)
mnng	27.7	1	17066439 (1)
trifluoromethanesulfonic acid	24.7	3	8699025 (1), 1310044 (1)

Search CenterWatch for drugs/clinical trials and news about MUC5AC / MUC5A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MUC5AC gene:

NM_017511.1

Unigene Clusters for MUC5AC:

Mucin 5AC, oligomeric mucus/gel-forming

Hs.534332 [show with all ESTs], Hs.558950 [show with all ESTs], Hs.721515 [show with all ESTs]

Unigene Representative Sequences: AJ001402, X81649, AJ298317

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534821(uc021qbr.1) ENST00000358378(uc001lsz.3 uc009ycs.2)

ENST00000356191

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Additional cDNA sequence:

AF015521.1 AF043909.1 AJ298317.1

6 DOTS entries:

DT.209839 DT.75121497 DT.91804067 DT.95323046 DT.95264442 DT.91804068

24/65 AceView cDNA sequences (see all 65):

BI761970 BV178834 BV174348 AI921630 CA433820 BC033831 Z48314 BM855872

BM782247 BM769723 AI677639 AJ001402 BM820970 AW298301 BI762047 BM854880

AI828184 AI924115 BM784694 BV204711 BV178294 AL833060 BV174347 AI925608

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MUC5AC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGTTACA

About this image

MUC5AC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Mucus-producing Cells

Selective marker (cell-identifying gene)

Lung

Trachea

Mucus-producing Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Mature airway epithelial cells (Directed differentia...)

Immature proximal lung cells (Directed differentia...)

Early proximal lung progenitors (Directed differentia...)

See MUC5AC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MUC5AC

SOURCE GeneReport for Unigene clusters: Hs.534332 Hs.558950 Hs.721515

UniProtKB/Swiss-Prot: MUC5A_HUMAN, P98088

Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed

in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum

SABiosciences Custom PCR Arrays for MUC5AC

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MUC5AC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MUC5AC gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 4)	Uncharacterized protein (see all 4)	56(a) 22(a) (see all 4)	many ↔ many many ↔ many (see all 4)	5(15823981-15825938) 5(15809744-15822873)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	8(a) 12(a) (see all 3)	many ↔ many many ↔ many (see all 3)	1(72015518-72085064) 1(71906025-71976150)
zebrafish (Danio rerio)	Actinopterygii	si:ch73-343m12.1⁶ CABZ01073388.1⁶ (see all 3)	--	5(a) 4(a) (see all 3)	possible ortholog possible ortholog (see all 3)	7(74859528-74903390) Zv9_NA551(7720-20743)

ENSEMBL Gene Tree for MUC5AC (if available)
TreeFam Gene Tree for MUC5AC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MUC5AC gene

TECTA² OTOG² MUC2² OTOGL² MUC6² MUC5B² MUC19² FCGBP²

VWF² BMPER²

6 SIMAP similar genes for MUC5AC using alignment to 16 protein entries: MUC5A_HUMAN (see all proteins):

MG1 MUC5B MLP MUC2 OTOG MUC19

MUC5AC for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MUC5AC
PGOHUM00000258306

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73395674^1,2	C,	--	978072(+)	`CTTTCC/ATGCCA`	1	--	us2k¹		1		WA	2
rs78154079^1,2	C,	--	978841(+)	`GTCGGC/TCATGG`	1	--	us2k¹		0	--	--	--	--
rs28469016^1,2	C,F,	--	978986(+)	`GGCACG/AGTGCC`	1	--	us2k¹		5		NA WA	244
rs118072449^1,2	C,F,	--	979565(+)	`GCTTCG/ACNNNN`	1	--	int¹		1		NA	120
rs55908559^1,2	C,	--	979621(+)	`ATCTCG/TGGCTT`	1	--	int¹		6		NS WA	282
rs55680540^1,2	C,F,	--	979685(+)	`CCACAG/ATATCT`	1	--	int¹		6		NS NA	306
rs56287011^1,2	C,	--	979730(+)	`GGCATC/TAGCCC`	1	--	int¹		5		NS	188
rs55939540^1,2	C,F,	--	980243(+)	`GCCCCG/ACCGTC`	1	--	int¹		7		NS WA NA	420
rs56185131^1,2	C,F,	--	980394(+)	`AGGCCG/ATCATC`	1	--	int¹		9		NS CSA WA NA EA	509
rs113938189^1,2	C,	--	981090(+)	`TGTGCA/GGGGCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MUC5AC (1151580 - 1222364 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MUC5AC: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MUC5AC for disorders           About GeneDecksing

OMIM gene information: 158373    OMIM disorders: --

20/110 diseases for MUC5AC (see all 110):    About MalaCards

pseudomyxoma peritonei otitis media dry eye syndrome anal canal adenocarcinoma

familial adenomatous polyposis graft versus host disease status asthmaticus sweat gland carcinoma

ampulla of vater adenocarcinoma barrett's esophagus pancreatic mucinous cystadenoma ampulla of vater carcinoma

peptic ulcer corneal ulcer cystic fibrosis diffuse panbronchiolitis

inflammatory bowel disease small intestine adenocarcinoma biliary papillomatosis panbronchiolitis

10/93 Novoseek disease relationships for MUC5AC gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metaplasia	81.1	55	10070955 (4), 10190312 (3), 17090193 (2), 14631367 (2) (see all 32)
carcinoma mucinous	77.4	22	12493022 (3), 12352188 (3), 17316416 (2), 11253133 (1) (see all 13)
airways disease	71.9	3	17200179 (1), 18539955 (1), 15205558 (1)
gastric carcinoma	71.8	60	15737028 (4), 9036879 (4), 11745219 (3), 15309883 (3) (see all 31)
adenocarcinoma	71.1	70	14699032 (3), 12877727 (3), 17090193 (2), 15910596 (2) (see all 46)
carcinoma	64.9	65	10227723 (4), 9495202 (4), 16596179 (4), 15272531 (4) (see all 32)
adenoma	61.5	59	10767823 (5), 10424888 (3), 10398114 (2), 17342306 (2) (see all 27)
cholangiocarcinoma	61.3	43	19639217 (4), 9495202 (4), 15213623 (4), 19094709 (2) (see all 15)
nasal polyps	58.4	31	15513533 (7), 18254322 (4), 20128280 (4), 20422702 (3) (see all 10)
barrett esophagus	58.2	6	16803684 (1), 17565646 (1), 14535999 (1), 12152167 (1) (see all 6)

Genetic Association Database (GAD): MUC5AC
Human Genome Epidemiology (HuGE) Navigator: MUC5AC (8 documents)

Export disorders for MUC5AC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MUC5AC gene, integrated from 9 sources (see all 676):
(articles sorted by number of sources associating them with MUC5AC)

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Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PubMed id 9588204)^{1, 3, 9} van de Bovenkamp J.H....Einerhand A.W. (1998)
Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PubMed id 7513696)^{1, 2, 9} Meerzaman D....Rose M.C. (1994)
The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. (PubMed id 14535999)^{1, 2, 9} Van de Bovenkamp J.H.... Dekker J. (2003)
Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PubMed id 8948439)^{1, 2, 9} Klomp L.W.... Strous G.J. (1995)
Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? (PubMed id 7826332)^{1, 3, 9} Guyonnet Duperat V....Porchet N. (1995)
Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. (PubMed id 16787389)^{1, 2} Lidell M.E. and Hansson G.C. (2006)
Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. (PubMed id 11535137)^{1, 2} Escande F.... Buisine M.P. (2001)
In vivo glycosylation of mucin tandem repeats. (PubMed id 11445551)^{1, 2} Silverman H.S....Harris A. (2001)
Polymorphism of human mucin genes in chest disease: possible significance of MUC2. (PubMed id 11062147)^{1, 4} Vinall L.E....Swallow D.M. (2000)
Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. (PubMed id 9506983)^{1, 2} Li D.... Basbaum C.B. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4586	HGNC: 7515	AceView: MUC5AC	Ensembl:ENSG00000215182	euGenes: HUgn4586
ECgene: MUC5AC	H-InvDB: MUC5AC

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MUC5AC	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MUC5AC	Genetics and Cytogenetics in Oncology and Haematology
Mucin database	http://www.medkem.gu.se/mucinbiology/databases/

Intellectual Property for MUC5AC gene
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MUC5AC Gene

mucin 5AC, oligomeric mucus/gel-forming

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MUC5AC Gene

mucin 5AC, oligomeric mucus/gel-forming

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